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Aliases for CYB5RL Gene

Aliases for CYB5RL Gene

  • Cytochrome B5 Reductase Like 2 3
  • Cytochrome B5 Reductase-Like 2 5
  • EC 4

External Ids for CYB5RL Gene

Previous GeneCards Identifiers for CYB5RL Gene

  • GC01M054410
  • GC01M054609
  • GC01M052753

Summaries for CYB5RL Gene

GeneCards Summary for CYB5RL Gene

CYB5RL (Cytochrome B5 Reductase Like) is a Protein Coding gene. Among its related pathways are Metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include oxidoreductase activity and cytochrome-b5 reductase activity, acting on NAD(P)H. An important paralog of this gene is ENSG00000256407.

UniProtKB/Swiss-Prot for CYB5RL Gene

  • NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB5RL Gene

Genomics for CYB5RL Gene

Regulatory Elements for CYB5RL Gene

Promoters for CYB5RL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYB5RL on UCSC Golden Path with GeneCards custom track

Genomic Location for CYB5RL Gene

54,172,336 bp from pter
54,200,073 bp from pter
27,738 bases
Minus strand

Genomic View for CYB5RL Gene

Genes around CYB5RL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB5RL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB5RL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB5RL Gene

Proteins for CYB5RL Gene

  • Protein details for CYB5RL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADH-cytochrome b5 reductase-like
    Protein Accession:
    Secondary Accessions:
    • B7ZBS4
    • Q8NF25

    Protein attributes for CYB5RL Gene

    315 amino acids
    Molecular mass:
    35892 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    • Sequence=BAC03437.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CD515193; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for CYB5RL Gene


neXtProt entry for CYB5RL Gene

Proteomics data for CYB5RL Gene at MOPED

Post-translational modifications for CYB5RL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYB5RL Gene

No data available for DME Specific Peptides for CYB5RL Gene

Domains & Families for CYB5RL Gene

Suggested Antigen Peptide Sequences for CYB5RL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FAD-binding FR-type domain.
  • Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
  • Contains 1 FAD-binding FR-type domain.
  • Contains 1 Oxidoreductase-like domain.
  • Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
genes like me logo Genes that share domains with CYB5RL: view

No data available for Gene Families for CYB5RL Gene

Function for CYB5RL Gene

Molecular function for CYB5RL Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
UniProtKB/Swiss-Prot Function:
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

Enzyme Numbers (IUBMB) for CYB5RL Gene

Animal Model Products

  • Taconic Biosciences Mouse Models for CYB5RL

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYB5RL Gene

Localization for CYB5RL Gene

Subcellular locations from

Jensen Localization Image for CYB5RL Gene COMPARTMENTS Subcellular localization image for CYB5RL gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CYB5RL Gene

Pathways & Interactions for CYB5RL Gene

genes like me logo Genes that share pathways with CYB5RL: view

Pathways by source for CYB5RL Gene

Interacting Proteins for CYB5RL Gene

Gene Ontology (GO) - Biological Process for CYB5RL Gene


No data available for SIGNOR curated interactions for CYB5RL Gene

Drugs & Compounds for CYB5RL Gene

(3) Drugs for CYB5RL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
NAD Pharma Full agonist, Agonist 0
NADH Nutra 0

(1) Additional Compounds for CYB5RL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with CYB5RL: view

Transcripts for CYB5RL Gene

mRNA/cDNA for CYB5RL Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYB5RL Gene

Cytochrome b5 reductase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYB5RL Gene

No ASD Table

Relevant External Links for CYB5RL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYB5RL Gene

mRNA expression in normal human tissues for CYB5RL Gene

SOURCE GeneReport for Unigene cluster for CYB5RL Gene Hs.591426

genes like me logo Genes that share expression patterns with CYB5RL: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CYB5RL Gene

Orthologs for CYB5RL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYB5RL Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CYB5RL 35
  • 86.2 (n)
  • 84.71 (a)
  • 85 (a)
(Mus musculus)
Mammalia Cyb5rl 35
  • 80.86 (n)
  • 78.12 (a)
Cyb5rl 16
Cyb5rl 36
  • 79 (a)
(Pan troglodytes)
Mammalia CYB5RL 35
  • 99.58 (n)
  • 99.37 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Cyb5rl 35
  • 82.23 (n)
  • 79.14 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
(Gallus gallus)
Aves -- 36
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001815 35
  • 44.38 (n)
  • 34.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7914 35
  • 44.36 (n)
  • 27.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM33 36
  • 19 (a)
CBR1 36
  • 26 (a)
PGA3 36
  • 20 (a)
Species with no ortholog for CYB5RL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYB5RL Gene

Gene Tree for CYB5RL (if available)
Gene Tree for CYB5RL (if available)

Paralogs for CYB5RL Gene

Paralogs for CYB5RL Gene

(1) SIMAP similar genes for CYB5RL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CYB5RL: view

Variants for CYB5RL Gene

Sequence variations from dbSNP and Humsavar for CYB5RL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs946448 - 54,195,477(-) GGCAA(A/G)GTGGG reference, missense
rs611903 -- 54,175,906(+) aatcc(C/T)ccatg intron-variant
rs596786 -- 54,183,844(+) GTGGC(A/G)CATGC intron-variant
rs670877 -- 54,172,024(-) ATGTG(C/T)TGGCC downstream-variant-500B
rs621359 -- 54,178,524(+) TGAGC(A/G)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYB5RL Gene

Variant ID Type Subtype PubMed ID
nsv871920 CNV Gain 21882294

Variation tolerance for CYB5RL Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.59; 93.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYB5RL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYB5RL Gene

Disorders for CYB5RL Gene

Relevant External Links for CYB5RL

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYB5RL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB5RL Gene

Publications for CYB5RL Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CYB5RL Gene

Sources for CYB5RL Gene

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