CYB5RL Gene
protein-coding GIFtS: 38
GCID: GC01M054609
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cytochrome b5 reductase-like
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Aliases
for CYB5RL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome B5 Reductase-Like1 2 | | LOC6064951 | | NADH-Cytochrome B5 Reductase-Like2 | | EC 1.6.2.23 |
Export aliases for CYB5RL gene to outside databasesPrevious GC identifers: GC01M054410 GC01M052753 |
Summaries
for CYB5RL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NB5R5_HUMAN, Q6IPT4Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterolbiosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity)
|
Genomic Views
for CYB5RL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYB5RL gene promoter:
USF1 RP58 Pax-5 AML1a CUTL1 HNF-3beta POU2F1 POU2F1a USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYB5RL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYB5RL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3CYB5RL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M054609: view genomic region
(about GC identifiers)
Start:
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54,638,009 bp from pter |
End:
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54,665,746 bp from pter |
Size:
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27,738 bases |
Orientation:
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minus strand |
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Proteins
for CYB5RL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NB5R5_HUMAN, Q6IPT4 (See
protein sequence)Recommended Name: NADH-cytochrome b5 reductase-like Size: 315 amino acids; 35892 Da
Cofactor: FAD (By similarity)
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=BAC03437.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=CD515193; Type=Frameshift; Positions=Several;
Secondary accessions: B7ZBS4 Q8NF25Alternative splicing: 3 isoforms: Q6IPT4-1 Q6IPT4-3 Q6IPT4-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CYB5RL: NX_Q6IPT4
CYB5RL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001026842.2
ENSEMBL proteins: ENSP00000403021 ENSP00000394709 ENSP00000431428 ENSP00000434343 ENSP00000287899 ENSP00000434606 ENSP00000431157 ENSP00000409075 ENSP00000438151 ENSP00000443797 ENSP00000383825
Human Recombinant Protein Products:
CYB5RL Antibody Products:
Assay Products for CYB5RL: |
Protein
Domains /
Families
for CYB5RL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYB5RL for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q6IPT4ProtoNet protein and cluster: Q6IPT4 UniProtKB/Swiss-Prot: NB5R5_HUMAN, Q6IPT4Similarity: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase familySimilarity: Contains 1 FAD-binding FR-type domainSimilarity: Contains 1 Oxidoreductase-like domain |
Function
for CYB5RL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NB5R5_HUMAN, Q6IPT4Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterolbiosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity)Catalytic activity: NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5Enzyme Number (IUBMB): EC 1.6.2.21
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5RL (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5RL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CYB5RL | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CYB5RL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB5RL |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H |
IEA | -- | | GO:0016491 | oxidoreductase activity |
-- | -- |
CYB5RL for ontologies About GeneDecksing
|
Pathways & Interactions
for CYB5RL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYB5RL
|
Drugs & Compounds
for CYB5RL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CYB5RL
3 HMDB Compounds for CYB5RL About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| FAD | 1H-Purin-6-amine flavin dinucleotide (see all 21) | 146-14-5 | -- | | NAD | 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28) | 53-84-9 | -- | | NADH | 1,4-Dihydronicotinamide adenine dinucleotide (see all 17) | 58-68-4 | -- |
Search CenterWatch for drugs/clinical trials and news about CYB5RL / NB5R5
|
Transcripts
for CYB5RL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYB5RL gene: NM_001031672.2 Unigene Cluster for CYB5RL: Cytochrome b5 reductase-like Hs.591426 [show with all ESTs]Unigene Representative Sequence: AK09045613 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000420054(uc001cww.3) ENST00000421415(uc001cwy.4) ENST00000490863(uc009vzo.3 uc001cwx.4)
ENST00000528287 ENST00000534324 ENST00000287899 ENST00000493530 ENST00000462299
ENST00000497820 ENST00000419823 ENST00000542737 ENST00000537208 ENST00000401046
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5RL (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5RL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYB5RL (NM_001031672) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYB5RL | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CYB5RL |
Additional cDNA sequence: AK090456.1 AK124632.1 BC012781.2 BC038388.1 BC049198.1 BC064419.1 9 DOTS entries: DT.40120951 DT.100022451 DT.101983645 DT.40219670 DT.409709 DT.91713877 DT.75105053 DT.91992184 DT.91939773
GeneLoc Exon Structure
|
Expression
for CYB5RL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYB5RL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAAACCCT
About this image
See CYB5RL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYB5RL
SOURCE GeneReport for Unigene cluster: Hs.591426
SABiosciences Custom PCR Arrays for CYB5RL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYB5RL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYB5RL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYB5RL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYB5RL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB5RL |
Orthologs
for CYB5RL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CYB5RL gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for CYB5RL (if available)
TreeFam Gene Tree for CYB5RL (if available) |
Paralogs
for CYB5RL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYB5RL gene
- ENSG000002564072
1 SIMAP similar gene for CYB5RL using alignment to 6 protein entries: NB5R5_HUMAN (see all proteins):CYB5R3
CYB5RL for paralogs About GeneDecksing
|
Genomic Variants
for CYB5RL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYB5RL (54638009 - 54665746 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYB5RL
1 CNV: 38994 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYB5RL |
|
Disorders
/ Diseases
for CYB5RL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYB5RL for disorders About GeneDecksing
3  diseases for CYB5RL: About MalaCardsmethemoglobinemia cholesterol malaria
1 disease from the University of Copenhagen DISEASES database for CYB5RL:Methemoglobinemia Export disorders for CYB5RL gene to outside databases
|
Publications
for CYB5RL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYB5RL gene integrated from 9 sources:
(articles sorted by number of sources associating them with CYB5RL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for CYB5RL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYB5RL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYB5RL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYB5RL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CYB5RL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CYB5RL gene:
Search GeneIP for patents involving CYB5RL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYB5RL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CYB5RL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYB5RL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYB5RL | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYB5RL | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5RL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5RL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | CYB5RL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB5RL |
|  |  |  | | | | Search ThermoFisher Antibodies for CYB5RL |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CYB5RL |
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