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Aliases for CYB5RL Gene

Aliases for CYB5RL Gene

  • Cytochrome B5 Reductase-Like 2 3
  • EC 4

External Ids for CYB5RL Gene

Previous GeneCards Identifiers for CYB5RL Gene

  • GC01M054410
  • GC01M054609
  • GC01M052753

Summaries for CYB5RL Gene

GeneCards Summary for CYB5RL Gene

CYB5RL (Cytochrome B5 Reductase-Like) is a Protein Coding gene. Diseases associated with CYB5RL include methemoglobinemia. GO annotations related to this gene include cytochrome-b5 reductase activity, acting on NAD(P)H. An important paralog of this gene is CYB5R1.

UniProtKB/Swiss-Prot for CYB5RL Gene

  • NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB5RL Gene

Genomics for CYB5RL Gene

Regulatory Elements for CYB5RL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYB5RL Gene

54,172,336 bp from pter
54,200,073 bp from pter
27,738 bases
Minus strand

Genomic View for CYB5RL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYB5RL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB5RL Gene

Proteins for CYB5RL Gene

  • Protein details for CYB5RL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADH-cytochrome b5 reductase-like
    Protein Accession:
    Secondary Accessions:
    • B7ZBS4
    • Q8NF25

    Protein attributes for CYB5RL Gene

    315 amino acids
    Molecular mass:
    35892 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    • Sequence=BAC03437.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CD515193; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for CYB5RL Gene


neXtProt entry for CYB5RL Gene

Proteomics data for CYB5RL Gene at MOPED

Post-translational modifications for CYB5RL Gene

No Post-translational modifications

Other Protein References for CYB5RL Gene

No data available for DME Specific Peptides for CYB5RL Gene

Domains for CYB5RL Gene

Suggested Antigen Peptide Sequences for CYB5RL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6IPT4
  • Contains 1 FAD-binding FR-type domain.
  • Contains 1 Oxidoreductase-like domain.
  • Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
genes like me logo Genes that share domains with CYB5RL: view

No data available for Gene Families for CYB5RL Gene

Function for CYB5RL Gene

Molecular function for CYB5RL Gene

UniProtKB/Swiss-Prot CatalyticActivity: NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5
UniProtKB/Swiss-Prot Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

Enzyme Numbers (IUBMB) for CYB5RL Gene

Gene Ontology (GO) - Molecular Function for CYB5RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with CYB5RL: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYB5RL Gene

Localization for CYB5RL Gene

Subcellular locations from

Jensen Localization Image for CYB5RL Gene COMPARTMENTS Subcellular localization image for CYB5RL gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYB5RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CYB5RL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CYB5RL Gene

Pathways for CYB5RL Gene

SuperPathways for CYB5RL Gene

No Data Available

Interacting Proteins for CYB5RL Gene

Gene Ontology (GO) - Biological Process for CYB5RL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYB5RL: view

No data available for Pathways by source for CYB5RL Gene

Compounds for CYB5RL Gene

(3) HMDB Compounds for CYB5RL Gene

Compound Synonyms Cas Number PubMed IDs
  • 1H-Purin-6-amine flavin dinucleotide
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
  • 1,4-Dihydronicotinamide adenine dinucleotide
genes like me logo Genes that share compounds with CYB5RL: view

Transcripts for CYB5RL Gene

mRNA/cDNA for CYB5RL Gene

(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYB5RL Gene

Cytochrome b5 reductase-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYB5RL

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYB5RL Gene

No ASD Table

Relevant External Links for CYB5RL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYB5RL Gene

mRNA expression in normal human tissues for CYB5RL Gene

SOURCE GeneReport for Unigene cluster for CYB5RL Gene Hs.591426

genes like me logo Genes that share expressions with CYB5RL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for CYB5RL Gene

Orthologs for CYB5RL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYB5RL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYB5RL 35
  • 99.58 (n)
  • 99.37 (a)
  • 99 (a)
(Canis familiaris)
Mammalia CYB5RL 35
  • 86.2 (n)
  • 84.71 (a)
  • 85 (a)
(Mus musculus)
Mammalia Cyb5rl 35
  • 80.86 (n)
  • 78.12 (a)
Cyb5rl 16
Cyb5rl 36
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
(Rattus norvegicus)
Mammalia Cyb5rl 35
  • 82.23 (n)
  • 79.14 (a)
(Gallus gallus)
Aves -- 36
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001815 35
  • 44.38 (n)
  • 34.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7914 35
  • 44.36 (n)
  • 27.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM33 36
  • 19 (a)
CBR1 36
  • 26 (a)
PGA3 36
  • 20 (a)
Species with no ortholog for CYB5RL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYB5RL Gene

Gene Tree for CYB5RL (if available)
Gene Tree for CYB5RL (if available)

Paralogs for CYB5RL Gene

Paralogs for CYB5RL Gene

Selected SIMAP similar genes for CYB5RL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CYB5RL: view

Variants for CYB5RL Gene

Sequence variations from dbSNP and Humsavar for CYB5RL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs596786 -- 54,183,844(+) GTGGC(A/G)CATGC intron-variant
rs611903 -- 54,175,906(+) aatcc(C/T)ccatg intron-variant
rs621359 -- 54,178,524(+) TGAGC(A/G)GAGGG intron-variant
rs670877 -- 54,172,024(-) ATGTG(C/T)TGGCC downstream-variant-500B
rs780503 -- 54,180,368(+) tggga(A/G)gccaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYB5RL Gene

Variant ID Type Subtype PubMed ID
nsv871920 CNV Gain 21882294

Relevant External Links for CYB5RL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYB5RL Gene

Disorders for CYB5RL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CYB5RL Gene including...

Search for CYB5RL Gene in MalaCards »

(1) University of Copenhagen DISEASES for CYB5RL Gene

Relevant External Links for CYB5RL

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with CYB5RL: view

No data available for UniProtKB/Swiss-Prot for CYB5RL Gene

Publications for CYB5RL Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. High-resolution whole-genome association study of Parkinson disease. (PMID: 16252231) Maraganore D.M. … Ballinger D.G. (Am. J. Hum. Genet. 2005) 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for CYB5RL Gene

Sources for CYB5RL Gene

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