Aliases for CYB5R4 Gene
External Ids for CYB5R4 Gene
Previous HGNC Symbols for CYB5R4 Gene
Previous GeneCards Identifiers for CYB5R4 Gene
NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010]
GeneCards Summary for CYB5R4 Gene
CYB5R4 (Cytochrome B5 Reductase 4) is a Protein Coding gene. Diseases associated with CYB5R4 include Methemoglobinemia and Maturity-Onset Diabetes Of The Young. Among its related pathways are Erythrocytes take up carbon dioxide and release oxygen and PAK Pathway. GO annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding. An important paralog of this gene is CYB5R3.
UniProtKB/Swiss-Prot for CYB5R4 Gene
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.