Aliases for CYB5R4 Gene
External Ids for CYB5R4 Gene
Previous HGNC Symbols for CYB5R4 Gene
Previous GeneCards Identifiers for CYB5R4 Gene
NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010]
GeneCards Summary for CYB5R4 Gene
CYB5R4 (Cytochrome B5 Reductase 4) is a Protein Coding gene. Diseases associated with CYB5R4 include Methemoglobinemia and Maturity-Onset Diabetes Of The Young. Among its related pathways are Erythrocytes take up carbon dioxide and release oxygen and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding. An important paralog of this gene is CYB5R3.
UniProtKB/Swiss-Prot for CYB5R4 Gene
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.