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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYB5R2 Gene

protein-coding   GIFtS: 60
GCID: GC11M007642

Cytochrome B5 Reductase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome B5 Reductase 21 2
EC 1.6.2.23 8
B5R.22
Cytochrome B5 Reductase B5R.22
NADH-Cytochrome B5 Reductase 22
b5R.23

External Ids:    HGNC: 243761   Entrez Gene: 517002   Ensembl: ENSG000001663947   OMIM: 6083425   UniProtKB: Q6BCY43   

Export aliases for CYB5R2 gene to outside databases

Previous GC identifers: GC11M008146 GC11M007645 GC11M007650 GC11M007345


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CYB5R2 Gene: 
CYB5R2 (cytochrome b5 reductase 2) is a protein-coding gene. Diseases associated with CYB5R2 include hypervitaminosis a, and methemoglobinemia, and among its related super-pathways are Cytochrome P450 - arranged by substrate type and PAK Pathway. GO annotations related to this gene include cytochrome-b5 reductase activity, acting on NAD(P)H. An important paralog of this gene is CYB5R3.

UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4
Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol
biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for
NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and
2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1)

Gene Wiki entry for CYB5R2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYB5R2 gene promoter:
         Pbx1a   AML1a   p53   Lmo2   MEF-2A   Cart-1   Chx10   Zic3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYB5R2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYB5R2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYB5R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

CYB5R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYB5R2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M007642:  view genomic region     (about GC identifiers)

Start:
7,686,326 bp from pter      End:
7,698,453 bp from pter
Size:
12,128 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4 (See protein sequence)
Recommended Name: NADH-cytochrome b5 reductase 2  
Size: 276 amino acids; 31458 Da
Cofactor: FAD (By similarity)
Secondary accessions: Q9BVA3 Q9UF68 Q9UHJ0
Alternative splicing: 2 isoforms:  Q6BCY4-1   Q6BCY4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYB5R2: NX_Q6BCY4

Explore proteomics data for CYB5R2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6BCY4

  • 4/6 DME Specific Peptides for CYB5R2 (Q6BCY4) (see all 6)
     AKYPLPL  LWYTLDR  GMIAGGTG  AGGTGITPMLQ 

    CYB5R2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYB5R2 Protein Expression
    REFSEQ proteins: NP_057313.2  
    ENSEMBL proteins: 
     ENSP00000435916   ENSP00000299498   ENSP00000437041   ENSP00000434969   ENSP00000433856  
     ENSP00000432482   ENSP00000392777   ENSP00000299497  

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    Cloud-Clone Corp. Proteins for CYB5R2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0016020membrane IDA10611283

    CYB5R2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR017927 Fd_Rdtase_FAD-bd
     IPR008333 OxRdtase_FAD-bd_dom
     IPR001433 OxRdtase_FAD/NAD-bd
     IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
     IPR001834 NADH-Cyt_B5_reductase

    Graphical View of Domain Structure for InterPro Entry Q6BCY4

    ProtoNet protein and cluster: Q6BCY4

    4 Blocks protein domains:
    IPB001433 Oxidoreductase FAD/NAD(P)-binding
    IPB001709 Flavoprotein pyridine nucleotide cytochrome reductase signature
    IPB001834 Cytochrome B5 reductase signature
    IPB008333 Oxidoreductase FAD-binding region


    UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4
    Similarity: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family
    Similarity: Contains 1 FAD-binding FR-type domain


    CYB5R2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NB5R2_HUMAN, Q6BCY4
    Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol
    biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for
    NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and
    2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1)
    Catalytic activity: NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5

         Enzyme Number (IUBMB): EC 1.6.2.21 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004128cytochrome-b5 reductase activity, acting on NAD(P)H IDA10611283
    GO:0016491oxidoreductase activity ----
         
    CYB5R2 for ontologies           About GeneDecksing


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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYB5R2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    cytochrome P4500.75
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CYB5R2
        Antioxidant Action of Vitamin-C

    1 BioSystems Pathway for CYB5R2
        cytochrome P450


    1         Kegg Pathway  (Kegg details for CYB5R2):
        Amino sugar and nucleotide sugar metabolism


    CYB5R2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYB5R2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/58 Interacting proteins for CYB5R2 (Q6BCY42, 3 ENSP000002994984) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016126sterol biosynthetic process IEA--
    GO:0055114oxidation-reduction process IDA10611283

    CYB5R2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYB5R2 (NB5R2)

    3 HMDB Compounds for CYB5R2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--

    Search CenterWatch for drugs/clinical trials and news about CYB5R2 / NB5R2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
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    About This Section

    REFSEQ mRNAs for CYB5R2 gene (2 alternative transcripts): 
    NM_001001336.1  NM_016229.3  

    Unigene Cluster for CYB5R2:

    Cytochrome b5 reductase 2
    Hs.414362  [show with all ESTs]
    Unigene Representative Sequence: AK022556
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524790(uc001mfn.3) ENST00000299498(uc001mfm.3) ENST00000528585
    ENST00000533558(uc009yfk.3) ENST00000526084(uc009yfl.1) ENST00000534698
    ENST00000532621 ENST00000534443 ENST00000531096 ENST00000527542 ENST00000532920
    ENST00000524608 ENST00000436351 ENST00000525307 ENST00000299497
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    Additional mRNA sequence: 

    AF169802.1 AK022556.1 AK290102.1 AK308543.1 AL133582.1 AY665398.1 

    14 DOTS entries:

    DT.443839  DT.100778364  DT.92422135  DT.97842931  DT.414862  DT.97842933  DT.97825145  DT.100731311 
    DT.100774087  DT.95098185  DT.95287103  DT.100725290  DT.100778363  DT.95137858 

    24/103 AceView cDNA sequences (see all 103):

    NM_016229 AY665398 BP369645 CB149369 AI904497 NM_001001336 BM462664 AA425316 
    AI658871 BG700193 BX117979 BG718067 BQ446236 BC001346 CB126153 BI544721 
    BG719099 CB215163 BF111621 BM977530 AA814725 AA339782 BM794272 BM452306 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CYB5R2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                                                                                                                                
    SP2:                                                                                                                          -                     
    SP3:                                                                                                                          -                     
    SP4:        -     -     -     -     -     -     -                                                                                                   
    SP5:              -     -     -     -     -     -                                                                                                   


    ECgene alternative splicing isoforms for CYB5R2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYB5R2 expression in normal human tissues (normalized intensities)      CYB5R2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTTCGCG
    CYB5R2 Expression
    About this image


    CYB5R2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Seminiferous Tubules
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Brain (Nervous System)
             Olfactory Bulb   

    See CYB5R2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYB5R2

    SOURCE GeneReport for Unigene cluster: Hs.414362

    UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4
    Tissue specificity: Restricted expression

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CYB5R2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyb5r21 , 5 cytochrome b5 reductase 21, 5 85.14(n)1
    82.25(a)1
      7 (57.21 cM)5
    3206351  NM_177216.41  NP_796190.11 
     1077484555 
    chicken
    (Gallus gallus)
    Aves CYB5R21 cytochrome b5 reductase 2 68.62(n)
    68.86(a)
      408182  XM_420957.3  XP_420957.2 
    lizard
    (Anolis carolinensis)
    Reptilia CYB5R26
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343237.1(1707400-1744410)
    zebrafish
    (Danio rerio)
    Actinopterygii cyb5r21 cytochrome b5 reductase 2 64.56(n)
    63.57(a)
      751641  NM_001045360.1  NP_001038825.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59466
    --
    49(a)
    1 → many
    3L(11810083-11815375)
    worm
    (Caenorhabditis elegans)
    Secernentea hpo-191 Protein HPO-19 60.1(n)
    60.23(a)
      179029  NM_072237.3  NP_504638.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CBR1(YIL043C)4 Microsomal cytochrome b reductase, not essential for more   --   9(274926-274072) 854768  NP_012221.2 


    ENSEMBL Gene Tree for CYB5R2 (if available)
    TreeFam Gene Tree for CYB5R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYB5R2 gene
    CYB5R32  CYB5R42  CYB5R12  
    2 SIMAP similar genes for CYB5R2 using alignment to 5 protein entries:     NB5R2_HUMAN (see all proteins):
    CYB5R3    CYB5R1

    CYB5R2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/379 SNPs in CYB5R2 are shown (see all 379)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125753001,2
    C,F,A,H--7685848(+) GGGGTC/TGGAGT 1 -- ds50018Minor allele frequency- T:0.18NA WA EA 370
    rs1923805521,2
    --7685885(+) ATAAAA/GTCGGC 1 -- ds50010--------
    rs42727741,2
    C,A--7685933(+) GGAGTG/ATGTCC 1 -- ds50015Minor allele frequency- A:0.23NA EA 246
    rs125773751,2
    C,F,A,H--7685951(+) ATGGGG/TGTGGC 1 -- ds50018Minor allele frequency- T:0.15NA WA EA 368
    rs570422381,2
    C--7686042(+) TCCCCC/GCCACC 1 -- ds50010--------
    rs1843423491,2
    --7686049(+) CACCCC/TGACAG 1 -- ds50010--------
    rs71053471,2
    C--7686050(+) ACCCCG/AACAGA 1 -- ds50014Minor allele frequency- A:0.24NA EA 244
    rs71062131,2
    C--7686058(+) AGACCC/GTCGTT 1 -- ds50013Minor allele frequency- G:0.23NA EA 242
    rs1511856051,2
    --7686095(+) GGCAGC/TTTCTG 1 -- ds50010--------
    rs101605471,2
    C,F,A,H--7686160(+) CCCTAG/TTGCCA 1 -- ds50019Minor allele frequency- T:0.32NA WA CSA EA 370

    HapMap Linkage Disequilibrium report for CYB5R2 (7686326 - 7698453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CYB5R2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv29577CNV Loss19812545
    dgv58n21CNV Loss19592680
    nsv526297CNV Loss19592680
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608342    OMIM disorders: --

    5 diseases for CYB5R2:    About MalaCards
    hypervitaminosis a    methemoglobinemia    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    cytochrome p450

    1 disease from the University of Copenhagen DISEASES database for CYB5R2:
    Methemoglobinemia

    CYB5R2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CYB5R2
    Human Genome Epidemiology (HuGE) Navigator: CYB5R2 (1 document)

    Export disorders for CYB5R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYB5R2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CYB5R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. (PubMed id 10611283)1, 2, 3 Zhu H.... Bunn H.F. (1999)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa. (PubMed id 15858218)1, 2 Baker M.A.... Aitken R.J. (2005)
    4. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    5. NRXN3 is a novel locus for waist circumference: a gen ome-wide association study from the CHARGE Consortium. (PubMed id 19557197)4 Heard-Costa N.L....North K.E. (2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    8. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51700 HGNC: 24376 AceView: CYB5R2 Ensembl:ENSG00000166394 euGenes: HUgn51700
    ECgene: CYB5R2 Kegg: 51700 H-InvDB: CYB5R2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYB5R2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYB5R2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYB5R2 gene:
    Search GeneIP for patents involving CYB5R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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