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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYB5R2 Gene

protein-coding GIFtS: 59
GCID: GC11M007642

cytochrome b5 reductase 2

Explore 5 diseases affiliated with
CYB5R2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome B5 Reductase 2¹ ²
EC 1.6.2.2³ ⁸
B5R.2²
Cytochrome B5 Reductase B5R.2²
NADH-Cytochrome B5 Reductase 2²
B5R.2²

External Ids:	HGNC: 24376¹	Entrez Gene: 51700²	Ensembl: ENSG00000166394⁷	OMIM: 608342⁵	UniProtKB: Q6BCY4³

Export aliases for CYB5R2 gene to outside databases

Previous GC identifers: GC11M008146 GC11M007645 GC11M007650 GC11M007345

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4

Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol

biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for

NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and

2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1)

Gene Wiki entry for CYB5R2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYB5R2 gene promoter:
Pbx1a AML1a p53 Lmo2 MEF-2A Cart-1 Chx10 Zic3 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYB5R2 promoter sequence

Search SABiosciences Chromatin IP Primers for CYB5R2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYB5R2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

CYB5R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYB5R2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M007642: view genomic region (about GC identifiers)

Start:	7,686,326 bp from pter	End:	7,698,453 bp from pter
Size:	12,128 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4 (See protein sequence)

Recommended Name: NADH-cytochrome b5 reductase 2

Size: 276 amino acids; 31458 Da

Cofactor: FAD (By similarity)

Secondary accessions: Q9BVA3 Q9UF68 Q9UHJ0

Alternative splicing: 2 isoforms: Q6BCY4-1 Q6BCY4-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYB5R2: NX_Q6BCY4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6BCY4

4/6 DME Specific Peptides for CYB5R2 (Q6BCY4) (see all 6)

AKYPLPL

LWYTLDR

GMIAGGTG

AGGTGITPMLQ

CYB5R2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057313.2

ENSEMBL proteins:

ENSP00000435916 ENSP00000299498 ENSP00000437041 ENSP00000434969 ENSP00000433856

ENSP00000432482 ENSP00000392777 ENSP00000299497

Human Recombinant Protein Products for CYB5R2:

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	Novus Biologicals CYB5R2 Protein Novus Biologicals CYB5R2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYB5R2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0016020	membrane	IDA	10611283

CYB5R2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CYB5R2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYB5R2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR017927 Fd_Rdtase_FAD-bd

IPR008333 OxRdtase_FAD-bd_dom

IPR001433 OxRdtase_FAD/NAD-bd

IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase

IPR001834 NADH-Cyt_B5_reductase

Graphical View of Domain Structure for InterPro Entry Q6BCY4

ProtoNet protein and cluster: Q6BCY4

4 Blocks protein families:

IPB001433 Oxidoreductase FAD/NAD(P)-binding

IPB001709 Flavoprotein pyridine nucleotide cytochrome reductase signature

IPB001834 Cytochrome B5 reductase signature

IPB008333 Oxidoreductase FAD-binding region

UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4

Similarity: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family

Similarity: Contains 1 FAD-binding FR-type domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NB5R2_HUMAN, Q6BCY4

Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol

biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for

NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and

2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1)

Catalytic activity: NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5

Enzyme Number (IUBMB): EC 1.6.2.2¹ ²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	IDA	10611283
GO:0016491	oxidoreductase activity	--	--

CYB5R2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CYB5R2

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		hsa-miR-205* hsa-miR-766
		SwitchGear 3'UTR luciferase reporter plasmid: CYB5R2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB5R2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Amino sugar and nucleotide sugar metabolism

Amino sugar and nucleotide sugar metabolism

1.00

Cytochrome P450 - arranged by substrate type

cytochrome P450

0.73

PAK Pathway

Antioxidant Action of Vitamin-C

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CYB5R2

Antioxidant Action of Vitamin-C

1 BioSystems Pathway for CYB5R2

cytochrome P450

1 Kegg Pathway (Kegg details for CYB5R2):

Amino sugar and nucleotide sugar metabolism

CYB5R2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYB5R2

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/58 Interacting proteins for CYB5R2 (Q6BCY4^{2, 3} ENSP00000299498⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 58)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016126	sterol biosynthetic process	IEA	--
GO:0055114	oxidation-reduction process	IDA	10611283

CYB5R2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYB5R2

3 HMDB Compounds for CYB5R2 About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--

Search CenterWatch for drugs/clinical trials and news about CYB5R2 / NB5R2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYB5R2 gene (2 alternative transcripts):

NM_001001336.1 NM_016229.3

Unigene Cluster for CYB5R2:

Cytochrome b5 reductase 2

Hs.414362 [show with all ESTs]

Unigene Representative Sequence: AK022556

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000524790(uc001mfn.3) ENST00000299498(uc001mfm.3) ENST00000528585

ENST00000533558(uc009yfk.3) ENST00000526084(uc009yfl.1) ENST00000534698

ENST00000532621 ENST00000534443 ENST00000531096 ENST00000527542 ENST00000532920

ENST00000524608 ENST00000436351 ENST00000525307 ENST00000299497

miRNA Products:		OriGene 3'-UTR Clone: CYB5R2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYB5R2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CYB5R2:
		hsa-miR-205* hsa-miR-766
		SwitchGear 3'UTR luciferase reporter plasmid: CYB5R2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYB5R2 (see all 7) OriGene shRNA RFP: CYB5R2 OriGene siRNA: CYB5R2
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		GenScript: all cDNA clones in your preferred vector: CYB5R2 (NM_016229)
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Additional cDNA sequence:

AF169802.1 AK022556.1 AK290102.1 AK308543.1 AL133582.1 AY665398.1

14 DOTS entries:

DT.443839 DT.100778364 DT.92422135 DT.97842931 DT.414862 DT.97842933 DT.97825145 DT.100731311

DT.100774087 DT.95098185 DT.95287103 DT.100725290 DT.100778363 DT.95137858

24/103 AceView cDNA sequences (see all 103):

AI904497 BP369645 CB149369 AY665398 NM_016229 NM_001001336 BG723242 BV179528

BU608330 AA425316 BM462664 BM968347 BQ431043 BG715090 BG721502 BI464073

BG700193 AA844403 BI544721 BM977139 BG718067 CB215163 BM817472 BG719099

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CYB5R2 (see all 10) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13	^	14a	·	14b	·	14c
SP1:
SP2:																																									-
SP3:																																									-
SP4:			-		-		-		-		-		-		-
SP5:					-		-		-		-		-		-

ECgene alternative splicing isoforms for CYB5R2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYB5R2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCTTCGCG

About this image

CYB5R2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CYB5R2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYB5R2

SOURCE GeneReport for Unigene cluster: Hs.414362

UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4

Tissue specificity: Restricted expression

SABiosciences Custom PCR Arrays for CYB5R2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB5R2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB5R2 gene from 7/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CYB5R2¹	cytochrome b5 reductase 2	68.62(n) 68.86(a)		408182 XM_420957.3 XP_420957.2
lizard (Anolis carolinensis)	Reptilia	CYB5R2⁶	--	69(a)	1 ↔ 1	GL343237.1(1734119-1744410)
zebrafish (Danio rerio)	Actinopterygii	cyb5r2¹	cytochrome b5 reductase 2	64.56(n) 63.57(a)		751641 NM_001045360.1 NP_001038825.1
fruit fly (Drosophila melanogaster)	Insecta	CG5946⁶	--	49(a)	1 → many	3L(11810083-11815375)
worm (Caenorhabditis elegans)	Secernentea	hpo-19¹	Protein HPO-19	60.1(n) 60.23(a)		179029 NM_072237.3 NP_504638.1
thale cress (Arabidopsis thaliana)	eudicotyledons	ATCBR⁶	cytochrome-b5 reductase	34(a)	1 → many	5(5864251-5866709)
rice (Oryza sativa)	Liliopsida	-- --	NADH-cytochrome b5 reductase, putative, expressed	37(a) 37(a)	many ↔ many many ↔ many	5(23965195-23968348) 1(34651031-34654445)

ENSEMBL Gene Tree for CYB5R2 (if available)
TreeFam Gene Tree for CYB5R2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYB5R2 gene

CYB5R3² CYB5R4² CYB5R1²

2 SIMAP similar genes for CYB5R2 using alignment to 5 protein entries: NB5R2_HUMAN (see all proteins):

CYB5R3 CYB5R1

CYB5R2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12575300^1,2	C,F,A,H	--	7685848(+)	`GGGGTC/TGGAGT`	1	--	ds500¹		8		NA WA EA	370
rs192380552^1,2		--	7685885(+)	`ATAAAA/GTCGGC`	1	--	ds500¹		0	--	--	--	--
rs4272774^1,2	C,A	--	7685933(+)	`GGAGTG/ATGTCC`	1	--	ds500¹		5		NA EA	246
rs12577375^1,2	C,F,A,H	--	7685951(+)	`ATGGGG/TGTGGC`	1	--	ds500¹		8		NA WA EA	368
rs57042238^1,2		--	7686042(+)	`TCCCCC/GCCACC`	1	--	ds500¹		0	--	--	--	--
rs184342349^1,2		--	7686049(+)	`CACCCC/TGACAG`	1	--	ds500¹		0	--	--	--	--
rs7105347^1,2	C	--	7686050(+)	`ACCCCG/AACAGA`	1	--	ds500¹		4		NA EA	244
rs7106213^1,2	C	--	7686058(+)	`AGACCC/GTCGTT`	1	--	ds500¹		3		NA EA	242
rs151185605^1,2		--	7686095(+)	`GGCAGC/TTTCTG`	1	--	ds500¹		0	--	--	--	--
rs10160547^1,2	C,F,A,H	--	7686160(+)	`CCCTAG/TTGCCA`	1	--	ds500¹		9		NA WA CSA EA	370

HapMap Linkage Disequilibrium report for CYB5R2 (7686326 - 7698453 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYB5R2
1 Indel: 65858

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYB5R2 for disorders           About GeneDecksing

OMIM gene information: 608342    OMIM disorders: --

5 diseases for CYB5R2:    About MalaCards

methemoglobinemia intrahepatic cholangiocarcinoma cholangiocarcinoma ataxia

cholesterol

2 diseases from the University of Copenhagen DISEASES database for CYB5R2:

Methemoglobinemia Hypervitaminosis A

Human Genome Epidemiology (HuGE) Navigator: CYB5R2 (1 document)

Export disorders for CYB5R2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYB5R2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CYB5R2)

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world of online information

Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. (PubMed id 10611283)^{1, 2, 3} Zhu H.... Bunn H.F. (1999)
Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa. (PubMed id 15858218)^{1, 2} Baker M.A.... Aitken R.J. (2005)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)¹ Wang A.G....Kim N.S. (2006)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51700	HGNC: 24376	AceView: CYB5R2	Ensembl:ENSG00000166394	euGenes: HUgn51700
ECgene: CYB5R2	Kegg: 51700	H-InvDB: CYB5R2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYB5R2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYB5R2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CYB5R2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYB5R2 gene:
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GeneCards and IP:
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CYB5R2 Gene

cytochrome b5 reductase 2

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CYB5R2 Gene

cytochrome b5 reductase 2

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