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CYB5R2 Gene

protein-coding   GIFtS: 61
GCID: GC11M007642

Cytochrome B5 Reductase 2

  See CYB5R2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytochrome B5 Reductase 21 2
EC 1.6.2.23 8
B5R.22
Cytochrome B5 Reductase B5R.22
NADH-Cytochrome B5 Reductase 22
b5R.23

External Ids:    HGNC: 243761   Entrez Gene: 517002   Ensembl: ENSG000001663947   OMIM: 6083425   UniProtKB: Q6BCY43   
ORGUL members:         

Export aliases for CYB5R2 gene to outside databases

Previous GC identifers: GC11M008146 GC11M007645 GC11M007650 GC11M007345


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CYB5R2 Gene:
CYB5R2 (cytochrome b5 reductase 2) is a protein-coding gene. Diseases associated with CYB5R2 include methemoglobinemia. GO annotations related to this gene include cytochrome-b5 reductase activity, acting on NAD(P)H. An important paralog of this gene is ENSG00000256407.

UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4
Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol
biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for
NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and
2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1)

Gene Wiki entry for CYB5R2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYB5R2 gene promoter:
         Pbx1a   AML1a   p53   Lmo2   MEF-2A   Cart-1   Chx10   Zic3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYB5R2 promoter sequence
   Search Chromatin IP Primers for CYB5R2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYB5R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

CYB5R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYB5R2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M007642:  view genomic region     (about GC identifiers)

Start:
7,686,326 bp from pter      End:
7,698,453 bp from pter
Size:
12,128 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4 (See protein sequence)
Recommended Name: NADH-cytochrome b5 reductase 2  
Size: 276 amino acids; 31458 Da
Cofactor: FAD (By similarity)
Secondary accessions: Q9BVA3 Q9UF68 Q9UHJ0
Alternative splicing: 2 isoforms:  Q6BCY4-1   Q6BCY4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYB5R2: NX_Q6BCY4

Explore proteomics data for CYB5R2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYB5R2 (Q6BCY4) (see all 6)
     AKYPLPL  LWYTLDR  GMIAGGTG  AGGTGITPMLQ 


    See CYB5R2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057313.2  
    ENSEMBL proteins: 
     ENSP00000435916   ENSP00000299498   ENSP00000437041   ENSP00000434969   ENSP00000433856  
     ENSP00000432482   ENSP00000392777   ENSP00000299497  

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    antibodies-online peptides for CYB5R2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR017927 Fd_Rdtase_FAD-bd
     IPR008333 OxRdtase_FAD-bd_dom
     IPR001433 OxRdtase_FAD/NAD-bd
     IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
     IPR001834 NADH-Cyt_B5_reductase

    Graphical View of Domain Structure for InterPro Entry Q6BCY4

    ProtoNet protein and cluster: Q6BCY4

    4 Blocks protein domains:
    IPB001433 Oxidoreductase FAD/NAD(P)-binding
    IPB001709 Flavoprotein pyridine nucleotide cytochrome reductase signature
    IPB001834 Cytochrome B5 reductase signature
    IPB008333 Oxidoreductase FAD-binding region


    UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4
    Similarity: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family
    Similarity: Contains 1 FAD-binding FR-type domain


    Find genes that share domains with CYB5R2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NB5R2_HUMAN, Q6BCY4
    Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol
    biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for
    NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and
    2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1)
    Catalytic activity: NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5

         Enzyme Number (IUBMB): EC 1.6.2.21 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004128cytochrome-b5 reductase activity, acting on NAD(P)H IDA10611283
    GO:0016491oxidoreductase activity ----
         
    Find genes that share ontologies with CYB5R2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Cyb5r2 (no phenotypes)

    Find genes that share phenotypes with CYB5R2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CYB5R2

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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0016020membrane IDA10611283

    Find genes that share ontologies with CYB5R2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYB5R2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    cytochrome P4500.74
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism


    Find genes that share SuperPaths with CYB5R2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CYB5R2
        Antioxidant Action of Vitamin-C

    1 BioSystems Pathway for CYB5R2
        cytochrome P450


    1 Kegg Pathway  (Kegg details for CYB5R2):
        Amino sugar and nucleotide sugar metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYB5R2
    Interactions:

        Search GeneGlobe Interaction Network for CYB5R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for CYB5R2 (Q6BCY42, 3 ENSP000002994984) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016126sterol biosynthetic process IEA--
    GO:0055114oxidation-reduction process IDA10611283

    Find genes that share ontologies with CYB5R2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for CYB5R2 (NB5R2)

    3 HMDB Compounds for CYB5R2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--

    1 PharmGKB related drug/compound annotation for CYB5R2 gene    About this table
    Drug/compound PharmGKB Annotation
    metoclopramide



    Find genes that share compounds with CYB5R2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYB5R2 gene (2 alternative transcripts): 
    NM_001001336.1  NM_016229.3  

    Unigene Cluster for CYB5R2:

    Cytochrome b5 reductase 2
    Hs.414362  [show with all ESTs]
    Unigene Representative Sequence: AK022556
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524790(uc001mfn.3) ENST00000299498(uc001mfm.3) ENST00000528585
    ENST00000533558(uc009yfk.3) ENST00000526084(uc009yfl.1) ENST00000534698
    ENST00000532621 ENST00000534443 ENST00000531096 ENST00000527542 ENST00000532920
    ENST00000524608 ENST00000436351 ENST00000525307 ENST00000299497
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    hsa-miR-205* hsa-miR-766
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    Additional mRNA sequence: 

    AF169802.1 AK022556.1 AK290102.1 AK308543.1 AL133582.1 AY665398.1 

    14 DOTS entries:

    DT.443839  DT.100778364  DT.92422135  DT.97842931  DT.414862  DT.97842933  DT.97825145  DT.100731311 
    DT.100774087  DT.95098185  DT.95287103  DT.100725290  DT.100778363  DT.95137858 

    Selected AceView cDNA sequences (see all 103):

    CB149369 AI904497 AY665398 NM_016229 NM_001001336 BP369645 BC001346 AA339782 
    CD642989 BF111621 BU634453 BI464073 AI830609 BI828454 BG718067 BG719099 
    AL133582 BM794272 BM691737 CB126153 AA844403 BM462664 BQ446236 BI544721 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYB5R2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                                                                                                                                
    SP2:                                                                                                                          -                     
    SP3:                                                                                                                          -                     
    SP4:        -     -     -     -     -     -     -                                                                                                   
    SP5:              -     -     -     -     -     -                                                                                                   


    ECgene alternative splicing isoforms for CYB5R2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYB5R2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTTCGCG
    CYB5R2 Expression
    About this image


    CYB5R2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Seminiferous Tubules
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
    CYB5R2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYB5R2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.414362

    UniProtKB/Swiss-Prot: NB5R2_HUMAN, Q6BCY4
    Tissue specificity: Restricted expression

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CYB5R2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyb5r21 , 5 cytochrome b5 reductase 21, 5 85.14(n)1
    82.25(a)1
      7 (57.21 cM)5
    3206351  NM_001205227.11  NP_001192156.11 
     1077484555 
    chicken
    (Gallus gallus)
    Aves CYB5R21 cytochrome b5 reductase 2 68.62(n)
    68.86(a)
      408182  NM_001271982.1  NP_001258911.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYB5R26
    cytochrome b5 reductase 2
    68(a)
    1 ↔ 1
    GL343237.1(1707400-1744410)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cyb5r21 cytochrome b5 reductase 2 66.42(n)
    66.55(a)
      595026  NM_001030467.1  NP_001025638.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyb5r21 cytochrome b5 reductase 2 63.86(n)
    62.64(a)
      751641  NM_001045360.1  NP_001038825.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59461 CG5946 57.97(n)
    57.72(a)
      39336  NM_168479.3  NP_729751.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hpo-191 hpo-19 59.65(n)
    58.65(a)
      179029  NM_072237.4  NP_504638.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CBR1(YIL043C)4
    CBR11
    Microsomal cytochrome b reductase, not essential for more4
    CBR11
    52.09(n)1
    43.72(a)1
      9(274926-274072)4
    8547681, 4  NP_012221.21, 4 


    ENSEMBL Gene Tree for CYB5R2 (if available)
    TreeFam Gene Tree for CYB5R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYB5R2 gene
    ENSG000002564072  CYB5R32  CYB5RL2  CYB5R42  CYB5R12  
    2 SIMAP similar genes for CYB5R2 using alignment to 5 protein entries:     NB5R2_HUMAN (see all proteins):
    CYB5R3    CYB5R1

    Find genes that share paralogs with CYB5R2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYB5R2 (see all 379)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125753001,2
    C,F,A,H--7685848(+) GGGGTC/TGGAGT 1 -- ds50018Minor allele frequency- T:0.18NA WA EA 370
    rs1923805521,2
    --7685885(+) ATAAAA/GTCGGC 1 -- ds50010--------
    rs42727741,2
    C,A--7685933(+) GGAGTG/ATGTCC 1 -- ds50015Minor allele frequency- A:0.23NA EA 246
    rs125773751,2
    C,F,A,H--7685951(+) ATGGGG/TGTGGC 1 -- ds50018Minor allele frequency- T:0.15NA WA EA 368
    rs570422381,2
    C--7686042(+) TCCCCC/GCCACC 1 -- ds50010--------
    rs1843423491,2
    --7686049(+) CACCCC/TGACAG 1 -- ds50010--------
    rs71053471,2
    C--7686050(+) ACCCCG/AACAGA 1 -- ds50014Minor allele frequency- A:0.24NA EA 244
    rs71062131,2
    C--7686058(+) AGACCC/GTCGTT 1 -- ds50013Minor allele frequency- G:0.23NA EA 242
    rs1511856051,2
    --7686095(+) GGCAGC/TTTCTG 1 -- ds50010--------
    rs101605471,2
    C,F,A,H--7686160(+) CCCTAG/TTGCCA 1 -- ds50019Minor allele frequency- T:0.32NA WA CSA EA 370

    HapMap Linkage Disequilibrium report for CYB5R2 (7686326 - 7698453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CYB5R2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv29577CNV Loss19812545
    dgv58n21CNV Loss19592680
    nsv526297CNV Loss19592680
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYB5R2
    DNA2.0 Custom Variant and Variant Library Synthesis for CYB5R2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608342    OMIM disorders: --

    1 disease for CYB5R2:    
    About MalaCards
    methemoglobinemia

    1 disease from the University of Copenhagen DISEASES database for CYB5R2:
    Methemoglobinemia

    Find genes that share disorders with CYB5R2           About GenesLikeMe

    Genetic Association Database (GAD): CYB5R2
    Human Genome Epidemiology (HuGE) Navigator: CYB5R2 (1 document)

    Export disorders for CYB5R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYB5R2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CYB5R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. (PubMed id 10611283)1, 2, 3 Zhu H.... Bunn H.F. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa. (PubMed id 15858218)1, 2 Baker M.A.... Aitken R.J. (Biol. Reprod. 2005)
    4. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. (PubMed id 23972371)1 Franceschini N....Zhu X. (Am. J. Hum. Genet. 2013)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. (PubMed id 19557197)4 Heard-Costa N.L....North K.E. (PLoS Genet. 2009)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51700 HGNC: 24376 AceView: CYB5R2 Ensembl:ENSG00000166394 euGenes: HUgn51700
    ECgene: CYB5R2 Kegg: 51700 H-InvDB: CYB5R2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYB5R2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYB5R2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYB5R2 gene:
    Search GeneIP for patents involving CYB5R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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