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CYB5D2 Gene

protein-coding   GIFtS: 48
GCID: GC17P004046

Cytochrome B5 Domain Containing 2

  Search for CYB5D2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome B5 Domain Containing 21 2
Cytochrome B5 Domain-Containing Protein 22 3
neuferricin2

External Ids:    HGNC: 284711   Entrez Gene: 1249362   Ensembl: ENSG000001677407   UniProtKB: Q8WUJ13   

Export aliases for CYB5D2 gene to outside databases

Previous GC identifer: GC17P003994


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CYB5D2 Gene:
CYB5D2 (cytochrome b5 domain containing 2) is a protein-coding gene. GO annotations related to this gene include heme binding. An important paralog of this gene is NENF.

UniProtKB/Swiss-Prot: NEUFC_HUMAN, Q8WUJ1
Function: Heme-binding protein which promotes neuronal but not astrocyte differentiation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYB5D2 gene promoter:
         Nkx3-1   SREBP-1c   NRSF form 1   HNF-4alpha2   NRSF form 2   HNF-4alpha1   SREBP-1b   Egr-4   SREBP-1a   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYB5D2 promoter sequence
   Search Chromatin IP Primers for CYB5D2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYB5D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

CYB5D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYB5D2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004046:  view genomic region     (about GC identifiers)

Start:
4,046,462 bp from pter      End:
4,090,605 bp from pter
Size:
44,144 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NEUFC_HUMAN, Q8WUJ1 (See protein sequence)
Recommended Name: Neuferricin precursor  
Size: 264 amino acids; 28690 Da
Secondary accessions: B2R7R6 D3DTJ9 I3L1K2
Alternative splicing: 2 isoforms:  Q8WUJ1-1   Q8WUJ1-3   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CYB5D2: NX_Q8WUJ1

Explore proteomics data for CYB5D2 at MOPED


See CYB5D2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001241684.1  NP_001241685.1  NP_653212.1  

ENSEMBL proteins: 
 ENSP00000458352   ENSP00000458903   ENSP00000301391   ENSP00000461090  

CYB5D2 Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for CYB5D2

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Cloud-Clone Corp. ELISAs for CYB5D2
Cloud-Clone Corp. CLIAs for CYB5D2
Search eBioscience for ELISAs for CYB5D2 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR001199 Cyt_B5-like_heme/steroid-bd

Graphical View of Domain Structure for InterPro Entry Q8WUJ1

ProtoNet protein and cluster: Q8WUJ1

1 Blocks protein domain: IPB001199 Cytochrome b5

UniProtKB/Swiss-Prot: NEUFC_HUMAN, Q8WUJ1
Domain: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved
iron-binding His residues at position 73 and 106 (By similarity)
Similarity: Belongs to the cytochrome b5 family. MAPR subfamily
Similarity: Contains 1 cytochrome b5 heme-binding domain


Find genes that share domains with CYB5D2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NEUFC_HUMAN, Q8WUJ1
Function: Heme-binding protein which promotes neuronal but not astrocyte differentiation (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0020037heme binding IEA--
     
Find genes that share ontologies with CYB5D2           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for CYB5D2:
 Decreased TP53 protein express 

     1 MGI phenotypic allele for Cyb5d2 (no phenotypes)

Find genes that share phenotypes with CYB5D2           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Cyb5d2tm1(KOMP)Wtsi for CYB5D2

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYB5D2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYB5D2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYB5D2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYB5D2

miRNA
Products:
    
miRTarBase miRNAs that target CYB5D2:
hsa-mir-183-5p (MIRT047145)

Block miRNA regulation of human, mouse, rat CYB5D2 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate CYB5D2:
hsa-miR-3200-5p hsa-miR-616* hsa-miR-373*
SwitchGear 3'UTR luciferase reporter plasmidCYB5D2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CYB5D2
Predesigned siRNA for gene silencing in human, mouse, rat CYB5D2

Gene Editing
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OriGene clones in human, mouse for CYB5D2 (see all 8)
OriGene ORF clones in mouse, rat for CYB5D2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CYB5D2 (NM_144611)
Sino Biological Human cDNA Clone for CYB5D2
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYB5D2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB5D2

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB5D2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NEUFC_HUMAN, Q8WUJ1: Secreted (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytoskeleton1
cytosol1
endoplasmic reticulum1
golgi apparatus1
nucleus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with CYB5D2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYB5D2
Interactions:

    Search GeneGlobe Interaction Network for CYB5D2

1 Interacting protein for CYB5D2 (Q8WUJ13) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PAPLNO954283I2D: score=5 
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007399nervous system development IEA--

Find genes that share ontologies with CYB5D2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CYB5D2 (NEUFC)

1 HMDB Compound for CYB5D2    About this table
CompoundSynonyms CAS #PubMed Ids
Heme(protoporphyrinato)iron (see all 19)14875-96-8--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CYB5D2 gene (3 alternative transcripts): 
NM_001254755.1  NM_001254756.1  NM_144611.3  

Unigene Cluster for CYB5D2:

Cytochrome b5 domain containing 2
Hs.513871  [show with all ESTs]
Unigene Representative Sequence: NM_144611
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000577075 ENST00000575251 ENST00000301391(uc002fxm.4 uc002fxl.4 uc010cko.3)
ENST00000573984 ENST00000575411
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CYB5D2 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate CYB5D2:
hsa-miR-3200-5p hsa-miR-616* hsa-miR-373*
SwitchGear 3'UTR luciferase reporter plasmidCYB5D2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CYB5D2
Predesigned siRNA for gene silencing in human, mouse, rat CYB5D2
Clone
Products:
     
OriGene clones in human, mouse for CYB5D2 (see all 8)
OriGene ORF clones in mouse, rat for CYB5D2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CYB5D2 (NM_144611)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYB5D2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB5D2
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CYB5D2
OriGene qSTAR qPCR primer pairs in human, mouse for CYB5D2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYB5D2
  QuantiTect SYBR Green Assays in human, mouse, rat CYB5D2
  QuantiFast Probe-based Assays in human, mouse, rat CYB5D2

Additional mRNA sequence: 

AK172844.1 AK313088.1 BC020263.1 BC051697.1 

13 DOTS entries:

DT.456353  DT.100809060  DT.95268275  DT.100025700  DT.120970255  DT.120970213  DT.120970249  DT.86854704 
DT.120970306  DT.91735132  DT.95268276  DT.91748244  DT.95335547 

Selected AceView cDNA sequences (see all 170):

AI688288 AA775255 R94393 CD370905 AV650263 AA877407 T71506 BQ887225 
BP351118 AI479980 CR621850 AI459843 BM455169 BM681125 AW273135 AA421572 
CR600228 AI151098 CR592653 BP369658 N57057 AA953573 BC051697 NM_144611 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYB5D2 (see all 8)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1:                    -     -     -     -           -           -           -                                       
SP2:                    -     -     -     -     -     -           -           -                                       
SP3:                          -     -     -     -     -           -           -                                       
SP4:                                            -     -           -           -                                       
SP5:                                      -     -     -           -           -                                       


ECgene alternative splicing isoforms for CYB5D2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CYB5D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACATTAAAGC
CYB5D2 Expression
About this image

CYB5D2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CYB5D2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.513871
    Custom PCR Arrays for CYB5D2
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB5D2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB5D2 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cyb5d21 , 5 cytochrome b5 domain containing 21, 5 81.92(n)1
82.63(a)1
  11 (44.51 cM)5
1929861  NM_001024926.31  NP_001020097.21 
 727772325 
chicken
(Gallus gallus)
Aves CYB5D21 cytochrome b5 domain containing 2 65.8(n)
63.91(a)
  417495  XM_415743.4  XP_415743.1 
tropical clawed frog
(Xenopus tropicalis)
Amphibia cyb5d21 cytochrome b5 domain containing 2 57.25(n)
57.4(a)
  548908  NM_001016154.1  NP_001016154.1 
zebrafish
(Danio rerio)
Actinopterygii cyb5d21 cytochrome b5 domain containing 2 55.66(n)
53.3(a)
  795950  NM_001102674.1  NP_001096144.1 
fruit fly
(Drosophila melanogaster)
Insecta CG120561 CG12056 50.76(n)
41.28(a)
  31855  NM_132307.4  NP_572535.1 
worm
(Caenorhabditis elegans)
Secernentea tag-1311 tag-131 50.44(n)
45.18(a)
  175557  NM_065467.3  NP_497868.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons MAPR41 MAPR4 46.97(n)
41.41(a)
  827155  NM_117583.7  NP_567451.1 
rice
(Oryza sativa)
Liliopsida Os03g02055001 Os03g0205500 42.05(n)
36.93(a)
  4331992  NM_001055849.2  NP_001049314.2 


ENSEMBL Gene Tree for CYB5D2 (if available)
TreeFam Gene Tree for CYB5D2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CYB5D2 gene
NENF2  
1 SIMAP similar gene for CYB5D2 using alignment to 2 protein entries:     NEUFC_HUMAN (see all proteins):
NENF

Find genes that share paralogs with CYB5D2           About GenesLikeMe


1 Pseudogenes.org Pseudogene for CYB5D2
PGOHUM00000262360


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CYB5D2 (see all 334)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0374874
A colorectal cancer sample4--see VAR_0374872 R G mis40--------
VAR_0374884
A colorectal cancer sample4--see VAR_0374882 R P mis40--------
rs1811112421,2
--3951040(+) GCCTGA/CCCCCG 3 -- int10--------
rs1834960311,2
--4048274(+) ACGGGA/GTTTCA 3 -- int10--------
rs1878751051,2
--4048293(+) GCCAGC/GATGGT 3 -- int10--------
rs620721791,2
C,F--4048312(+) CCTGAC/TCTTAT 3 -- int11Minor allele frequency- T:0.50NA 2
rs20540411,2
C,H--4048327(+) CGCCCG/ACCTTG 3 -- int17Minor allele frequency- A:0.07NA WA 14
rs1416338591,2
C--4048518(+) GTCATC/TATCTT 3 -- int10--------
rs347676761,2
C,F--4048572(+) CTTCCC/TTCTGT 3 -- int11Minor allele frequency- T:0.03NA 120
rs798394331,2
F--4048669(+) GGGAAG/AGGACT 3 -- int11Minor allele frequency- A:0.06WA 118

HapMap Linkage Disequilibrium report for CYB5D2 (4046462 - 4090605 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for CYB5D2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv519311CNV Loss19592680
nsv527709CNV Loss19592680
esv29231CNV Loss19812545
esv2751682CNV Gain17911159
nsv457647CNV Gain19166990
dgv173n21CNV Gain19592680
nsv833344CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CYB5D2
DNA2.0 Custom Variant and Variant Library Synthesis for CYB5D2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CYB5D2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with CYB5D2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genetic predictors of risk and resilience in psychiatric disorders: A cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. (PubMed id 24039173)1 McGrath L.M....Smoller J.W. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013)
  2. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
  3. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 124936 HGNC: 28471 AceView: MGC32124 Ensembl:ENSG00000167740 euGenes: HUgn124936
ECgene: CYB5D2 H-InvDB: CYB5D2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CYB5D2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CYB5D2 gene:
Search GeneIP for patents involving CYB5D2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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