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Aliases for CYB5D2 Gene

Aliases for CYB5D2 Gene

  • Cytochrome B5 Domain Containing 2 2 3
  • Cytochrome B5 Domain-Containing Protein 2 3 4
  • Neuferricin 3

External Ids for CYB5D2 Gene

Previous GeneCards Identifiers for CYB5D2 Gene

  • GC17P003994
  • GC17P004046

Summaries for CYB5D2 Gene

GeneCards Summary for CYB5D2 Gene

CYB5D2 (Cytochrome B5 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include heme binding. An important paralog of this gene is NENF.

UniProtKB/Swiss-Prot for CYB5D2 Gene

  • Heme-binding protein which promotes neuronal but not astrocyte differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB5D2 Gene

Genomics for CYB5D2 Gene

Regulatory Elements for CYB5D2 Gene

Genomic Location for CYB5D2 Gene

Start:
4,143,168 bp from pter
End:
4,187,310 bp from pter
Size:
44,143 bases
Orientation:
Plus strand

Genomic View for CYB5D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYB5D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB5D2 Gene

Proteins for CYB5D2 Gene

  • Protein details for CYB5D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUJ1-NEUFC_HUMAN
    Recommended name:
    Neuferricin
    Protein Accession:
    Q8WUJ1
    Secondary Accessions:
    • B2R7R6
    • D3DTJ9
    • I3L1K2

    Protein attributes for CYB5D2 Gene

    Size:
    264 amino acids
    Molecular mass:
    28690 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYB5D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYB5D2 Gene

Proteomics data for CYB5D2 Gene at MOPED

Post-translational modifications for CYB5D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYB5D2 Gene

No data available for DME Specific Peptides for CYB5D2 Gene

Domains for CYB5D2 Gene

Protein Domains for CYB5D2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYB5D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUJ1

UniProtKB/Swiss-Prot:

NEUFC_HUMAN :
  • Q8WUJ1
Domain:
  • The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 73 and 106.
  • Contains 1 cytochrome b5 heme-binding domain.
Family:
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with CYB5D2: view

No data available for Gene Families for CYB5D2 Gene

Function for CYB5D2 Gene

Molecular function for CYB5D2 Gene

UniProtKB/Swiss-Prot Function: Heme-binding protein which promotes neuronal but not astrocyte differentiation.

Gene Ontology (GO) - Molecular Function for CYB5D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0020037 heme binding IBA --
genes like me logo Genes that share ontologies with CYB5D2: view

Phenotypes for CYB5D2 Gene

genes like me logo Genes that share phenotypes with CYB5D2: view

miRNA for CYB5D2 Gene

miRTarBase miRNAs that target CYB5D2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYB5D2 Gene

Localization for CYB5D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB5D2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYB5D2 Gene COMPARTMENTS Subcellular localization image for CYB5D2 gene
Compartment Confidence
extracellular 3
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CYB5D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with CYB5D2: view

Pathways for CYB5D2 Gene

SuperPathways for CYB5D2 Gene

No Data Available

Interacting Proteins for CYB5D2 Gene

Selected Interacting proteins: Q8WUJ1-NEUFC_HUMAN for CYB5D2 Gene via I2D

Symbol External ID(s) Details
PAPLN

Gene Ontology (GO) - Biological Process for CYB5D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development --
GO:0045666 positive regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with CYB5D2: view

No data available for Pathways by source for CYB5D2 Gene

Compounds for CYB5D2 Gene

(1) HMDB Compounds for CYB5D2 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
genes like me logo Genes that share compounds with CYB5D2: view

Transcripts for CYB5D2 Gene

Unigene Clusters for CYB5D2 Gene

Cytochrome b5 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYB5D2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - -
SP7: -
SP8: -

Relevant External Links for CYB5D2 Gene

GeneLoc Exon Structure for
CYB5D2
ECgene alternative splicing isoforms for
CYB5D2

Expression for CYB5D2 Gene

mRNA expression in normal human tissues for CYB5D2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CYB5D2 Gene

SOURCE GeneReport for Unigene cluster for CYB5D2 Gene Hs.513871

genes like me logo Genes that share expressions with CYB5D2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CYB5D2 Gene

Orthologs for CYB5D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB5D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC454442 35
  • 98.77 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CYB5D2 35
  • 85.77 (n)
  • 84.1 (a)
CYB5D2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYB5D2 35
  • 80.97 (n)
  • 81.12 (a)
CYB5D2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyb5d2 35
  • 81.92 (n)
  • 82.63 (a)
Cyb5d2 16
Cyb5d2 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYB5D2 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyb5d2 35
  • 82.49 (n)
  • 82.2 (a)
chicken
(Gallus gallus)
Aves CYB5D2 35
  • 65.8 (n)
  • 63.91 (a)
CYB5D2 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyb5d2 35
  • 57.25 (n)
  • 57.4 (a)
zebrafish
(Danio rerio)
Actinopterygii cyb5d2 35
  • 55.66 (n)
  • 53.3 (a)
cyb5d2 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001042 35
  • 46.99 (n)
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12056 35
  • 50.76 (n)
  • 41.28 (a)
CG12056 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-131 35
  • 50.44 (n)
  • 45.18 (a)
tag-131 36
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MAPR4 35
  • 46.97 (n)
  • 41.41 (a)
rice
(Oryza sativa)
Liliopsida Os03g0205500 35
  • 42.05 (n)
  • 36.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9270 36
  • 38 (a)
OneToMany
Species with no ortholog for CYB5D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYB5D2 Gene

ENSEMBL:
Gene Tree for CYB5D2 (if available)
TreeFam:
Gene Tree for CYB5D2 (if available)

Paralogs for CYB5D2 Gene

Paralogs for CYB5D2 Gene

Selected SIMAP similar genes for CYB5D2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CYB5D2 Gene

genes like me logo Genes that share paralogs with CYB5D2: view

Variants for CYB5D2 Gene

Sequence variations from dbSNP and Humsavar for CYB5D2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs897027 -- 4,148,996(+) cacgc(A/G)ggctg intron-variant
rs1049523 -- 4,157,188(+) GGAGG(G/T)TCTGG utr-variant-3-prime
rs1992158 -- 4,153,807(-) ACCTG(C/G)ATTAG intron-variant
rs1992159 -- 4,153,529(-) tccga(C/T)gcctg intron-variant
rs2054041 -- 4,145,033(+) CGCCC(A/G)CCTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYB5D2 Gene

Variant ID Type Subtype PubMed ID
nsv833344 CNV Gain 17160897
nsv457647 CNV Gain 19166990
esv2751682 CNV Gain 17911159
dgv173n21 CNV Gain 19592680
nsv519311 CNV Loss 19592680
nsv527709 CNV Loss 19592680
esv29231 CNV Loss 19812545

Relevant External Links for CYB5D2 Gene

HapMap Linkage Disequilibrium report
CYB5D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYB5D2 Gene

Disorders for CYB5D2 Gene

No disorders were found for CYB5D2 Gene.

No data available for UniProtKB/Swiss-Prot for CYB5D2 Gene

Publications for CYB5D2 Gene

  1. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Genetic predictors of risk and resilience in psychiatric disorders: A cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. (PMID: 24039173) McGrath L.M. … Smoller J.W. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013) 3

Products for CYB5D2 Gene

Sources for CYB5D2 Gene

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