CYB5D1 Gene
protein-coding GIFtS: 40
GCID: GC17P007761
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cytochrome b5 domain containing 1
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Aliases
for CYB5D1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome B5 Domain Containing 11 2 | | FLJ324991 | | Cytochrome B5 Domain-Containing Protein 12 |
Export aliases for CYB5D1 gene to outside databasesPrevious GC identifer: GC17P007704 |
Summaries
for CYB5D1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CYB5D1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYB5D1 gene promoter:
Pax-6 Lmo2 Olf-1 Nkx2-5 NF-kappaB LCR-F1 c-Ets-1 NF-kappaB1 NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYB5D1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYB5D1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1CYB5D1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P007761: view genomic region
(about GC identifiers)
Start:
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7,761,064 bp from pter |
End:
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7,765,600 bp from pter |
Size:
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4,537 bases |
Orientation:
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plus strand |
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Proteins
for CYB5D1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CB5D1_HUMAN, Q6P9G0 (See
protein sequence)Recommended Name: Cytochrome b5 domain-containing protein 1 Size: 228 amino acids; 26689 Da
Secondary accessions: D3DTQ8 Q96DM7Alternative splicing: 2 isoforms: Q6P9G0-1 Q6P9G0-2 Explore the universe of human proteins at neXtProt for CYB5D1: NX_Q6P9G0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P9G0
CYB5D1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653208.2
ENSEMBL proteins: ENSP00000459369 ENSP00000331479 ENSP00000461852 ENSP00000460105
Human Recombinant Protein Products:
CYB5D1 Antibody Products:
Assay Products for CYB5D1: |
Protein
Domains /
Families
for CYB5D1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYB5D1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6P9G0ProtoNet protein and cluster: Q6P9G0 1 Blocks protein family: IPB001199 Cytochrome b5
UniProtKB/Swiss-Prot: CB5D1_HUMAN, Q6P9G0Similarity: Belongs to the cytochrome b5 familySimilarity: Contains 1 cytochrome b5 heme-binding domain |
Function
for CYB5D1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5D1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5D1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYB5D1 (NM_144607) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYB5D1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB5D1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB5D1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0020037 | heme binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
CYB5D1 for ontologies About GeneDecksing
|
Pathways & Interactions
for CYB5D1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYB5D1
|
Drugs & Compounds
for CYB5D1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CYB5D1
1 HMDB Compound for CYB5D1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
Search CenterWatch for drugs/clinical trials and news about CYB5D1 / CB5D1
|
Transcripts
for CYB5D1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYB5D1 gene: NM_144607.4 Unigene Cluster for CYB5D1: Cytochrome b5 domain containing 1 Hs.27475 [show with all ESTs]Unigene Representative Sequence: NM_1446077 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000571846 ENST00000332439(uc002gjb.4) ENST00000541486 ENST00000574357
ENST00000570446 ENST00000573940 ENST00000574196
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5D1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5D1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYB5D1 (NM_144607) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYB5D1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB5D1 |
Additional cDNA sequence: AK022811.1 AK057061.1 AK124743.1 AK125598.1 AK289520.1 BC060779.1 8 DOTS entries: DT.455686 DT.100693757 DT.120935814 DT.95094182 DT.75169263 DT.120935816 DT.120935850 DT.92070137 24/255 AceView cDNA sequences (see all 255): AW952285 AA991279 BI092918 CD365458 AI151324 NM_203411 AU149978 BC057812 BM849688 AI671664 C00123 BQ015649 BQ721168 AW293774 BQ649062 BC035897 BG222892 BQ012561 BE467057 BQ063399 BC009994 AI394006 AA355717 BU734395
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CYB5D1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|
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| SP1: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for CYB5D1
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Expression
for CYB5D1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYB5D1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTTTCCAG
About this image
See CYB5D1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYB5D1
SOURCE GeneReport for Unigene cluster: Hs.27475
SABiosciences Custom PCR Arrays for CYB5D1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYB5D1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CYB5D1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYB5D1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYB5D1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB5D1 |
Orthologs
for CYB5D1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CYB5D1 gene from 4/19 species (see all 19) About this table
ENSEMBL Gene Tree for CYB5D1 (if available)
TreeFam Gene Tree for CYB5D1 (if available) |
Paralogs
for CYB5D1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CYB5D1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYB5D1 (7761064 - 7765600 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYB5D1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYB5D1 |
|
Disorders
/ Diseases
for CYB5D1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CYB5D1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYB5D1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CYB5D1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for CYB5D1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CYB5D1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYB5D1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYB5D1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CYB5D1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CYB5D1 gene:
Search GeneIP for patents involving CYB5D1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYB5D1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CYB5D1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYB5D1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYB5D1 | | | OriGene Protein Over-expression Lysate for CYB5D1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for CYB5D1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5D1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB5D1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYB5D1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYB5D1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYB5D1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYB5D1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYB5D1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYB5D1 |
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 |  |  |  | |
| | | | Search Tocris compounds for CYB5D1 |
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 | | | CYB5D1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB5D1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CYB5D1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB5D1 |
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