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Aliases for CYB5D1 Gene

Aliases for CYB5D1 Gene

  • Cytochrome B5 Domain Containing 1 2 3 5

External Ids for CYB5D1 Gene

Previous GeneCards Identifiers for CYB5D1 Gene

  • GC17P007704
  • GC17P007761

Summaries for CYB5D1 Gene

GeneCards Summary for CYB5D1 Gene

CYB5D1 (Cytochrome B5 Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include heme binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB5D1 Gene

Genomics for CYB5D1 Gene

Regulatory Elements for CYB5D1 Gene

Enhancers for CYB5D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CYB5D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYB5D1 Gene

7,857,746 bp from pter
7,863,486 bp from pter
5,741 bases
Plus strand

Genomic View for CYB5D1 Gene

Genes around CYB5D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB5D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB5D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB5D1 Gene

Proteins for CYB5D1 Gene

  • Protein details for CYB5D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome b5 domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DTQ8
    • Q96DM7

    Protein attributes for CYB5D1 Gene

    228 amino acids
    Molecular mass:
    26689 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYB5D1 Gene


neXtProt entry for CYB5D1 Gene

Post-translational modifications for CYB5D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYB5D1 Gene

No data available for DME Specific Peptides for CYB5D1 Gene

Domains & Families for CYB5D1 Gene

Protein Domains for CYB5D1 Gene


Suggested Antigen Peptide Sequences for CYB5D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 cytochrome b5 heme-binding domain.
  • Belongs to the cytochrome b5 family.
  • Contains 1 cytochrome b5 heme-binding domain.
  • Belongs to the cytochrome b5 family.
genes like me logo Genes that share domains with CYB5D1: view

No data available for Gene Families for CYB5D1 Gene

Function for CYB5D1 Gene

Gene Ontology (GO) - Molecular Function for CYB5D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYB5D1: view
genes like me logo Genes that share phenotypes with CYB5D1: view

Animal Models for CYB5D1 Gene

MGI Knock Outs for CYB5D1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYB5D1 Gene

Localization for CYB5D1 Gene

Subcellular locations from

Jensen Localization Image for CYB5D1 Gene COMPARTMENTS Subcellular localization image for CYB5D1 gene
Compartment Confidence
golgi apparatus 2
nucleus 2
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CYB5D1 Gene

Pathways & Interactions for CYB5D1 Gene

SuperPathways for CYB5D1 Gene

No Data Available

Interacting Proteins for CYB5D1 Gene

Selected Interacting proteins: Q6P9G0-CB5D1_HUMAN for CYB5D1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CYB5D1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CYB5D1 Gene

Drugs & Compounds for CYB5D1 Gene

(1) Drugs for CYB5D1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with CYB5D1: view

Transcripts for CYB5D1 Gene

Unigene Clusters for CYB5D1 Gene

Cytochrome b5 domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYB5D1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: - - - - - -
SP6: -

Relevant External Links for CYB5D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYB5D1 Gene

mRNA expression in normal human tissues for CYB5D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CYB5D1 Gene:


SOURCE GeneReport for Unigene cluster for CYB5D1 Gene:

genes like me logo Genes that share expression patterns with CYB5D1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CYB5D1 Gene

Orthologs for CYB5D1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYB5D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CYB5D1 34
  • 89.04 (n)
  • 87.72 (a)
CYB5D1 35
  • 84 (a)
(Canis familiaris)
Mammalia CYB5D1 34
  • 88.01 (n)
  • 88.16 (a)
CYB5D1 35
  • 88 (a)
(Mus musculus)
Mammalia Cyb5d1 34
  • 81.87 (n)
  • 83.33 (a)
Cyb5d1 16
Cyb5d1 35
  • 83 (a)
Gm6685 35
  • 83 (a)
(Pan troglodytes)
Mammalia LOC455210 34
  • 99.71 (n)
  • 99.56 (a)
CYB5D1 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Cyb5d1 34
  • 83.77 (n)
  • 84.65 (a)
(Monodelphis domestica)
Mammalia CYB5D1 35
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia CYB5D1 35
  • 64 (a)
(Anolis carolinensis)
Reptilia CYB5D1 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyb5d1 34
  • 65.56 (n)
  • 63.98 (a)
(Danio rerio)
Actinopterygii cyb5d1 34
  • 65.41 (n)
  • 68.4 (a)
Dr.17571 34
cyb5d1 35
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14115 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010016 34
  • 44.78 (n)
  • 36.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15429 34
  • 53.4 (n)
  • 39.29 (a)
CG15429 35
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 64 (a)
Species where no ortholog for CYB5D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYB5D1 Gene

Gene Tree for CYB5D1 (if available)
Gene Tree for CYB5D1 (if available)

Paralogs for CYB5D1 Gene

No data available for Paralogs for CYB5D1 Gene

Variants for CYB5D1 Gene

Sequence variations from dbSNP and Humsavar for CYB5D1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_037486 -

Structural Variations from Database of Genomic Variants (DGV) for CYB5D1 Gene

Variant ID Type Subtype PubMed ID
dgv510n67 CNV gain 20364138
nsv833351 CNV loss 17160897

Variation tolerance for CYB5D1 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.43; 88.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYB5D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYB5D1 Gene

Disorders for CYB5D1 Gene

Relevant External Links for CYB5D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYB5D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB5D1 Gene

Publications for CYB5D1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 65
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for CYB5D1 Gene

Sources for CYB5D1 Gene

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