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Aliases for CYB5B Gene

Aliases for CYB5B Gene

  • Cytochrome B5 Type B (Outer Mitochondrial Membrane) 2 3
  • Cytochrome B5 Outer Mitochondrial Membrane Isoform 3 4
  • CYPB5M 3 6
  • OMB5 3 4
  • Outer Mitochondrial Membrane Cytochrome B5 3
  • Cytochrome B5 Type B 3
  • Type 2 Cyt-B5 3
  • CYB5-M 3
  • CYB5M 4

External Ids for CYB5B Gene

Summaries for CYB5B Gene

GeneCards Summary for CYB5B Gene

CYB5B (Cytochrome B5 Type B (Outer Mitochondrial Membrane)) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include heme binding. An important paralog of this gene is CYB5A.

UniProtKB/Swiss-Prot for CYB5B Gene

  • Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB5B Gene

Genomics for CYB5B Gene

Genomic Location for CYB5B Gene

Start:
69,424,525 bp from pter
End:
69,466,266 bp from pter
Size:
41,742 bases
Orientation:
Plus strand

Genomic View for CYB5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYB5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB5B Gene

Regulatory Elements for CYB5B Gene

Proteins for CYB5B Gene

  • Protein details for CYB5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43169-CYB5B_HUMAN
    Recommended name:
    Cytochrome b5 type B
    Protein Accession:
    O43169
    Secondary Accessions:
    • A8K6B1
    • Q96CC3
    • Q9BT35

    Protein attributes for CYB5B Gene

    Size:
    146 amino acids
    Molecular mass:
    16332 Da
    Quaternary structure:
    • Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2.

    Three dimensional structures from OCA and Proteopedia for CYB5B Gene

neXtProt entry for CYB5B Gene

Proteomics data for CYB5B Gene at MOPED

Post-translational modifications for CYB5B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys35 and Lys88

Other Protein References for CYB5B Gene

No data available for DME Specific Peptides for CYB5B Gene

Domains for CYB5B Gene

Protein Domains for CYB5B Gene

UniProtKB/Swiss-Prot:

CYB5B_HUMAN
Domain:
  • Contains 1 cytochrome b5 heme-binding domain.:
    • O43169
Family:
  • Belongs to the cytochrome b5 family.:
    • O43169
genes like me logo Genes that share domains with CYB5B: view

No data available for Gene Families for CYB5B Gene

Function for CYB5B Gene

Molecular function for CYB5B Gene

UniProtKB/Swiss-Prot Function: Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

Gene Ontology (GO) - Molecular Function for CYB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity --
GO:0020037 heme binding IDA 20861021
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYB5B: view

miRNA for CYB5B Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYB5B Gene

Localization for CYB5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB5B Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYB5B Gene COMPARTMENTS Subcellular localization image for CYB5B gene
Compartment Confidence
cytosol 3
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYB5B: view

Pathways for CYB5B Gene

SuperPathways for CYB5B Gene

genes like me logo Genes that share pathways with CYB5B: view

Pathways by source for CYB5B Gene

1 BioSystems pathway for CYB5B Gene

Gene Ontology (GO) - Biological Process for CYB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043085 positive regulation of catalytic activity --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYB5B: view

Compounds for CYB5B Gene

(2) HMDB Compounds for CYB5B Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4

(1) Drugbank Compounds for CYB5B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Heme
target
genes like me logo Genes that share compounds with CYB5B: view

Transcripts for CYB5B Gene

Unigene Clusters for CYB5B Gene

Cytochrome b5 type B (outer mitochondrial membrane):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYB5B Gene

No ASD Table

Relevant External Links for CYB5B Gene

GeneLoc Exon Structure for
CYB5B
ECgene alternative splicing isoforms for
CYB5B

Expression for CYB5B Gene

mRNA expression in normal human tissues for CYB5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYB5B Gene

This gene is overexpressed in Adrenal Gland (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYB5B Gene

SOURCE GeneReport for Unigene cluster for CYB5B Gene Hs.461131

genes like me logo Genes that share expressions with CYB5B: view

Orthologs for CYB5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYB5B 36
  • 99.56 (n)
  • 100 (a)
CYB5B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYB5B 36
  • 84.02 (n)
  • 80.82 (a)
CYB5B 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 47 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyb5b 36
  • 80.82 (n)
  • 75.34 (a)
Cyb5b 16
Cyb5b 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 60 (a)
OneToMany
-- 37
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CYB5B 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyb5b 36
  • 82.42 (n)
  • 74.66 (a)
chicken
(Gallus gallus)
Aves CYB5B 36
  • 71.82 (n)
  • 68.29 (a)
CYB5B 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYB5B 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyb5b 36
  • 62.08 (n)
  • 60.14 (a)
zebrafish
(Danio rerio)
Actinopterygii cyb5b 36
  • 57.05 (n)
  • 51.68 (a)
cyb5b 37
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3566 37
  • 45 (a)
ManyToMany
CG5157 37
  • 40 (a)
ManyToMany
CG6870 37
  • 31 (a)
ManyToMany
Cyt-b5 37
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cytb-5.1 37
  • 41 (a)
ManyToMany
cytb-5.2 36
  • 54.87 (n)
  • 47.79 (a)
cytb-5.2 37
  • 33 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL223W 36
  • 50.93 (n)
  • 44.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYB5 36
  • 49.55 (n)
  • 39.64 (a)
CYB5 37
  • 35 (a)
OneToMany
CYB5 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23672g 36
  • 48.54 (n)
  • 36.84 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CB5-D 36
  • 51.28 (n)
  • 43.08 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03910 36
  • 56.81 (n)
  • 49.3 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oca8 36
  • 51.79 (n)
  • 43.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7428 37
  • 51 (a)
OneToMany
Species with no ortholog for CYB5B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYB5B Gene

ENSEMBL:
Gene Tree for CYB5B (if available)
TreeFam:
Gene Tree for CYB5B (if available)

Paralogs for CYB5B Gene

Paralogs for CYB5B Gene

Selected SIMAP similar genes for CYB5B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CYB5B Gene

genes like me logo Genes that share paralogs with CYB5B: view

Variants for CYB5B Gene

Sequence variations from dbSNP and Humsavar for CYB5B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs165970 -- 69,443,814(+) TGTGC(C/T)ACTGC intron-variant
rs185001 -- 69,427,068(-) GAGAC(A/G)AGGTT intron-variant
rs185002 -- 69,433,353(-) TAACT(G/T)TAGGA intron-variant
rs246132 -- 69,439,364(+) cgcca(C/T)caggc intron-variant
rs246133 -- 69,440,213(+) gtttt(A/G)aatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYB5B Gene

Variant ID Type Subtype PubMed ID
nsv509629 CNV Insertion 20534489

Relevant External Links for CYB5B Gene

HapMap Linkage Disequilibrium report
CYB5B

Disorders for CYB5B Gene

Relevant External Links for CYB5B

Genetic Association Database (GAD)
CYB5B
Human Genome Epidemiology (HuGE) Navigator
CYB5B
genes like me logo Genes that share disorders with CYB5B: view

No data available for UniProtKB/Swiss-Prot for CYB5B Gene

Publications for CYB5B Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  2. Assessment of the ability of type 2 cytochrome b5 to modulate 17,20-lyase activity of human P450c17. (PMID: 11867265) Soucy P. … Luu-The V. (J. Steroid Biochem. Mol. Biol. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Mammalian mitochondrial and microsomal cytochromes b(5) exhibit divergent structural and biophysical characteristics. (PMID: 14733950) Altuve A. … Rivera M. (Biochem. Biophys. Res. Commun. 2004) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CYB5B Gene

Sources for CYB5B Gene

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