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Aliases for CYB5B Gene

Aliases for CYB5B Gene

  • Cytochrome B5 Type B 2 3
  • Cytochrome B5 Type B (Outer Mitochondrial Membrane) 2 3 5
  • Cytochrome B5 Outer Mitochondrial Membrane Isoform 3 4
  • OMB5 3 4
  • Outer Mitochondrial Membrane Cytochrome B5 3
  • Type 2 Cyt-B5 3
  • CYB5-M 3
  • CYPB5M 3
  • CYB5M 4

External Ids for CYB5B Gene

Previous GeneCards Identifiers for CYB5B Gene

  • GC16P068017
  • GC16P069458
  • GC16P055336

Summaries for CYB5B Gene

GeneCards Summary for CYB5B Gene

CYB5B (Cytochrome B5 Type B) is a Protein Coding gene. Among its related pathways are cytochrome P450. GO annotations related to this gene include heme binding and enzyme activator activity. An important paralog of this gene is CYB5A.

UniProtKB/Swiss-Prot for CYB5B Gene

  • Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB5B Gene

Genomics for CYB5B Gene

Regulatory Elements for CYB5B Gene

Promoters for CYB5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYB5B on UCSC Golden Path with GeneCards custom track

Genomic Location for CYB5B Gene

Chromosome:
16
Start:
69,424,525 bp from pter
End:
69,466,266 bp from pter
Size:
41,742 bases
Orientation:
Plus strand

Genomic View for CYB5B Gene

Genes around CYB5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB5B Gene

Proteins for CYB5B Gene

  • Protein details for CYB5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43169-CYB5B_HUMAN
    Recommended name:
    Cytochrome b5 type B
    Protein Accession:
    O43169
    Secondary Accessions:
    • A8K6B1
    • Q96CC3
    • Q9BT35

    Protein attributes for CYB5B Gene

    Size:
    146 amino acids
    Molecular mass:
    16332 Da
    Quaternary structure:
    • Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2.

    Three dimensional structures from OCA and Proteopedia for CYB5B Gene

neXtProt entry for CYB5B Gene

Proteomics data for CYB5B Gene at MOPED

Post-translational modifications for CYB5B Gene

  • Ubiquitination at Lys 88
  • Modification sites at PhosphoSitePlus

Other Protein References for CYB5B Gene

No data available for DME Specific Peptides for CYB5B Gene

Domains & Families for CYB5B Gene

Protein Domains for CYB5B Gene

Suggested Antigen Peptide Sequences for CYB5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43169

UniProtKB/Swiss-Prot:

CYB5B_HUMAN :
  • Contains 1 cytochrome b5 heme-binding domain.
  • Belongs to the cytochrome b5 family.
Domain:
  • Contains 1 cytochrome b5 heme-binding domain.
Family:
  • Belongs to the cytochrome b5 family.
genes like me logo Genes that share domains with CYB5B: view

No data available for Gene Families for CYB5B Gene

Function for CYB5B Gene

Molecular function for CYB5B Gene

UniProtKB/Swiss-Prot Function:
Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

Gene Ontology (GO) - Molecular Function for CYB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0020037 heme binding IEA,IDA 20861021
genes like me logo Genes that share ontologies with CYB5B: view
genes like me logo Genes that share phenotypes with CYB5B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYB5B Gene

Localization for CYB5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB5B Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYB5B Gene COMPARTMENTS Subcellular localization image for CYB5B gene
Compartment Confidence
mitochondrion 4
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYB5B: view

Pathways & Interactions for CYB5B Gene

SuperPathways for CYB5B Gene

Superpath Contained pathways
1 cytochrome P450
genes like me logo Genes that share pathways with CYB5B: view

Pathways by source for CYB5B Gene

1 BioSystems pathway for CYB5B Gene

Gene Ontology (GO) - Biological Process for CYB5B Gene

None

No data available for SIGNOR curated interactions for CYB5B Gene

Drugs & Compounds for CYB5B Gene

(2) Drugs for CYB5B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
NADH Nutra 0
genes like me logo Genes that share compounds with CYB5B: view

Transcripts for CYB5B Gene

Unigene Clusters for CYB5B Gene

Cytochrome b5 type B (outer mitochondrial membrane):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYB5B Gene

No ASD Table

Relevant External Links for CYB5B Gene

GeneLoc Exon Structure for
CYB5B
ECgene alternative splicing isoforms for
CYB5B

Expression for CYB5B Gene

mRNA expression in normal human tissues for CYB5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYB5B Gene

This gene is overexpressed in Adrenal Gland (x6.5).

Protein differential expression in normal tissues from HIPED for CYB5B Gene

This gene is overexpressed in Nasal epithelium (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYB5B Gene



SOURCE GeneReport for Unigene cluster for CYB5B Gene Hs.461131

genes like me logo Genes that share expression patterns with CYB5B: view

Protein tissue co-expression partners for CYB5B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CYB5B Gene

Orthologs for CYB5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYB5B 36
  • 100 (a)
OneToOne
CYB5B 35
  • 99.56 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CYB5B 35
  • 84.02 (n)
  • 80.82 (a)
CYB5B 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 47 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyb5b 16
Cyb5b 36
  • 75 (a)
OneToOne
Cyb5b 35
  • 80.82 (n)
  • 75.34 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CYB5B 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyb5b 35
  • 82.42 (n)
  • 74.66 (a)
chicken
(Gallus gallus)
Aves CYB5B 35
  • 71.82 (n)
  • 68.29 (a)
CYB5B 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYB5B 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyb5b 35
  • 62.08 (n)
  • 60.14 (a)
zebrafish
(Danio rerio)
Actinopterygii cyb5b 35
  • 57.05 (n)
  • 51.68 (a)
cyb5b 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3566 36
  • 45 (a)
ManyToMany
CG5157 36
  • 40 (a)
ManyToMany
CG6870 36
  • 31 (a)
ManyToMany
Cyt-b5 36
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cytb-5.1 36
  • 41 (a)
ManyToMany
cytb-5.2 36
  • 33 (a)
ManyToMany
cytb-5.2 35
  • 54.87 (n)
  • 47.79 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL223W 35
  • 50.93 (n)
  • 44.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYB5 35
  • 49.55 (n)
  • 39.64 (a)
CYB5 36
  • 35 (a)
OneToMany
CYB5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23672g 35
  • 48.54 (n)
  • 36.84 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CB5-D 35
  • 51.28 (n)
  • 43.08 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03910 35
  • 56.81 (n)
  • 49.3 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oca8 35
  • 51.79 (n)
  • 43.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7428 36
  • 51 (a)
OneToMany
Species with no ortholog for CYB5B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYB5B Gene

ENSEMBL:
Gene Tree for CYB5B (if available)
TreeFam:
Gene Tree for CYB5B (if available)

Paralogs for CYB5B Gene

Paralogs for CYB5B Gene

(5) SIMAP similar genes for CYB5B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CYB5B Gene

genes like me logo Genes that share paralogs with CYB5B: view

Variants for CYB5B Gene

Sequence variations from dbSNP and Humsavar for CYB5B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs185001 -- 69,427,068(-) GAGAC(A/G)AGGTT intron-variant
rs185002 -- 69,433,353(-) TAACT(G/T)TAGGA intron-variant
rs246136 -- 69,443,282(+) TGCCC(A/G)TGAGC intron-variant
rs246137 -- 69,444,337(+) GCCGG(G/T)GCTCT intron-variant
rs246139 -- 69,427,921(-) cctcc(C/T)gggtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYB5B Gene

Variant ID Type Subtype PubMed ID
nsv509629 CNV Insertion 20534489

Variation tolerance for CYB5B Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYB5B Gene

HapMap Linkage Disequilibrium report
CYB5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYB5B Gene

Disorders for CYB5B Gene

Relevant External Links for CYB5B

Genetic Association Database (GAD)
CYB5B
Human Genome Epidemiology (HuGE) Navigator
CYB5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYB5B

No disorders were found for CYB5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB5B Gene

Publications for CYB5B Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Mammalian mitochondrial and microsomal cytochromes b(5) exhibit divergent structural and biophysical characteristics. (PMID: 14733950) Altuve A. … Rivera M. (Biochem. Biophys. Res. Commun. 2004) 2 3
  3. Assessment of the ability of type 2 cytochrome b5 to modulate 17,20-lyase activity of human P450c17. (PMID: 11867265) Soucy P. … Luu-The V. (J. Steroid Biochem. Mol. Biol. 2002) 2 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung Y.J. … Rao D.C. (Am. J. Hypertens. 2015) 3

Products for CYB5B Gene

Sources for CYB5B Gene

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