CYB561D2 Gene
protein-coding GIFtS : 50
GCID: GC03 P050388
cytochrome b-561 domain containing 2
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Aliasesfor CYB561D2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cytochrome B-561 Domain Containing 2 1 2 101F61 2 3 5 TSP101 2 Putative Tumor Suppressor Protein 101F62 3 Cytochrome B561 Domain-Containing Protein 22 Putative Tumor Suppressor 101F62
Export aliases for CYB561D2 gene to outside databases Previous GC identifers: GC03P050348 GC03P050363
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Summariesfor CYB561D2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor CYB561D2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CYB561D2 gene promoter: AP-1 ATF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for CYB561D2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CYB561D2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3 CYB561D2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P050388: view genomic region
(about GC identifiers )
Start:
50,388,126 bp from pter
End:
50,395,891 bp from pter
Size:
7,766 bases
Orientation:
plus strand
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Proteinsfor CYB561D2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: C56D2_HUMAN, O14569 (See
protein sequence )Recommended Name: Cytochrome b561 domain-containing protein 2 Size : 222 amino acids; 23974 Da
Cofactor : Binds 2 heme groups non-covalently (By similarity)
Subcellular location : Membrane; Multi-pass membrane protein (Probable)
Secondary accessions : A8K552Explore the universe of human proteins at neXtProt for CYB561D2: NX_O14569 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O14569 CYB561D2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_008953.1 ENSEMBL proteins: ENSP00000400454 ENSP00000410663 ENSP00000232508 ENSP00000391209 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
CYB561D2 for ontologies About GeneDecksing CYB561D2 Antibody Products: Assay Products for CYB561D2:
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Protein
Domains / Familiesfor CYB561D2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CYB561D2 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O14569 ProtoNet protein and cluster: O14569
UniProtKB/Swiss-Prot: C56D2_HUMAN, O14569 Similarity : Contains 1 cytochrome b561 domain
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Functionfor CYB561D2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CYB561D2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CYB561D2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CYB561D2 (NM_007022 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYB561D2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CYB561D2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB561D2
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0046872 metal ion binding
IEA --
CYB561D2 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for CYB561D2 :
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Pathways & Interactionsfor CYB561D2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYB561D2 1 Interacting protein for CYB561D2 (O14569 2 , 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0022900 electron transport chain
IEA --
CYB561D2 for ontologies About GeneDecksing
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Drugs & Compoundsfor CYB561D2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CYB561D2 1 HMDB Compound for CYB561D2 About this table Compound Synonyms
CAS
# PubMed Ids Heme (protoporphyrinato)iron (see all 19 ) 14875-96-8 --
Search CenterWatch for drugs/clinical trials and news about CYB561D2 / C56D2
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Transcriptsfor CYB561D2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CYB561D2 gene: NM_007022.3 Unigene Cluster for CYB561D2:
Cytochrome b-561 domain containing 2 Hs.149443 [show with all ESTs ] Unigene Representative Sequence: BX641103 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000425346 (uc003dam.3 ) ENST00000424512 ENST00000232508 (uc003dal.3 )ENST00000418577 ENST00000419046 ENST00000490926 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CYB561D2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CYB561D2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CYB561D2 (NM_007022 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYB561D2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CYB561D2
Additional cDNA sequence: AF040704.1 AK291167.1 BC047691.1 BX641103.1
14 DOTS entries : DT.100884971 DT.91774243
DT.100884950 DT.91842030 DT.101985533 DT.121642948 DT.100884948 DT.109213 DT.91774250 DT.95143048 DT.100884975 DT.120873128 DT.456391 DT.85105475 24/177 AceView cDNA sequences (see all 177 ):
BM829861 BU179244 AA477130 AA421268 BQ225414 CB142328 BE550419 CA488481 AA454950 BM849656 CK725177 AA454561 CA454269 AA235070 AA807710 AI659172 AI738716 BE857589 BG150490 AF040704 BU739316 AI635352 CR598666 BM852873 GeneLoc Exon Structure
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Expression for CYB561D2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CYB561D2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGTCTGGATG
About this image See CYB561D2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CYB561D2 SOURCE GeneReport for Unigene cluster: Hs.149443 SABiosciences Custom PCR Arrays for CYB561D2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CYB561D2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CYB561D2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CYB561D2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CYB561D2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB561D2
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Orthologsfor CYB561D2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for CYB561D2 gene from 6/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for CYB561D2 (if available)TreeFam Gene Tree for CYB561D2 (if available)
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Paralogsfor CYB561D2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CYB561D2 gene CYB561D1 2 1 SIMAP similar gene for CYB561D2 using alignment to 1 protein entry: C56D2_HUMAN :CYB561D1
CYB561D2 for paralogs About GeneDecksing
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Genomic Variantsfor CYB561D2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CYB561D2 (50388126 - 50395891 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for CYB561D2 3 CNVs : 30176 4335 4336
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CYB561D2
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Disorders
/ Diseasesfor CYB561D2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CYB561D2 for disorders About GeneDecksing
OMIM gene information: 607068
OMIM disorders : --1 disease for CYB561D2 : About MalaCards lung cancer Export disorders for CYB561D2 gene to outside databases
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Publicationsfor CYB561D2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CYB561D2 gene, integrated from 9 sources (see all 14 ): (articles sorted by number of sources associating them with CYB561D2) Utopia : connect your pdf to the dynamic world of online information
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536) 1 , 2 , 3 Lerman M.I. and Minna J.D. (2000) The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997) 1 , 2 Muzny D.M....Gibbs R.A. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase. (PubMed id 9122200) 1 , 3 Townsley F.M.... Ruderman J.V. (1997) Functional expression and characterization of human 1 01F6 protein, a homologue of cytochrome b561 and a candidate tumor suppressor g ene product. (PubMed id 19734123) 1 , 9 Recuenco M.C....Tsubaki M. (2009) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Global profiling of protease cleavage sites by chemos elective labeling of protein N-termini. (PubMed id 19892738) 2 Xu G....Jaffrey S.R. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004)
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External Searches for CYB561D2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CYB561D2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CYB561D2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CYB561D2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for CYB561D2 gene: Search GeneIP for patents involving CYB561D2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CYB561D2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for CYB561D2 OriGene shRNA RFP for CYB561D2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CYB561D2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CYB561D2 OriGene Protein Over-expression Lysate for CYB561D2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CYB561D2 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CYB561D2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CYB561D2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CYB561D2 OriGene Custom Protein Services for CYB561D2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYB561D2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CYB561D2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CYB561D2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CYB561D2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CYB561D2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CYB561D2
CYB561D2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB561D2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CYB561D2
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Aliases for CYB561D2
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Disorders / Diseases for CYB561D2
Domains / Families for CYB561D2
Drugs / Compounds for CYB561D2
Expression for CYB561D2
Function for CYB561D2
Genomic Views for CYB561D2
Intellectual Property for CYB561D2
Orthologs for CYB561D2
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Pathways / Interactions for CYB561D2
Products for CYB561D2
Proteins for CYB561D2
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Transcripts for CYB561D2
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