Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYB561D2 Gene

Aliases for CYB561D2 Gene

  • Cytochrome B561 Family, Member D2 2 3
  • 101F6 3 4 6
  • Putative Tumor Suppressor Protein 101F6 3 4
  • Cytochrome B561 Domain-Containing Protein 2 3
  • Cytochrome B-561 Domain Containing 2 2
  • Putative Tumor Suppressor 101F6 2
  • XXcos-LUCA11.4 3
  • TSP10 3

External Ids for CYB561D2 Gene

Previous GeneCards Identifiers for CYB561D2 Gene

  • GC03P050348
  • GC03P050363
  • GC03P050388

Summaries for CYB561D2 Gene

GeneCards Summary for CYB561D2 Gene

CYB561D2 (Cytochrome B561 Family, Member D2) is a Protein Coding gene. An important paralog of this gene is CYB561D1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB561D2 Gene

Genomics for CYB561D2 Gene

Regulatory Elements for CYB561D2 Gene

Transcription factor binding sites by QIAGEN in the CYB561D2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYB561D2 Gene

Start:
50,350,695 bp from pter
End:
50,358,460 bp from pter
Size:
7,766 bases
Orientation:
Plus strand

Genomic View for CYB561D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYB561D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB561D2 Gene

Proteins for CYB561D2 Gene

  • Protein details for CYB561D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14569-C56D2_HUMAN
    Recommended name:
    Cytochrome b561 domain-containing protein 2
    Protein Accession:
    O14569
    Secondary Accessions:
    • A8K552

    Protein attributes for CYB561D2 Gene

    Size:
    222 amino acids
    Molecular mass:
    23974 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 2 heme groups non-covalently.;
    Quaternary structure:
    No Data Available

neXtProt entry for CYB561D2 Gene

Proteomics data for CYB561D2 Gene at MOPED

Post-translational modifications for CYB561D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYB561D2 Gene

Antibody Products

No data available for DME Specific Peptides for CYB561D2 Gene

Domains for CYB561D2 Gene

Gene Families for CYB561D2 Gene

HGNC:
  • CYB :Cytochrome b genes

Protein Domains for CYB561D2 Gene

Suggested Antigen Peptide Sequences for CYB561D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14569

UniProtKB/Swiss-Prot:

C56D2_HUMAN :
  • O14569
Domain:
  • Contains 1 cytochrome b561 domain.
genes like me logo Genes that share domains with CYB561D2: view

Function for CYB561D2 Gene

Gene Ontology (GO) - Molecular Function for CYB561D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYB561D2: view

Phenotypes for CYB561D2 Gene

GenomeRNAi human phenotypes for CYB561D2:
genes like me logo Genes that share phenotypes with CYB561D2: view

Animal Model Products

CRISPR Products

miRNA for CYB561D2 Gene

miRTarBase miRNAs that target CYB561D2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYB561D2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYB561D2 Gene

Localization for CYB561D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB561D2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYB561D2 Gene COMPARTMENTS Subcellular localization image for CYB561D2 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CYB561D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYB561D2: view

Pathways for CYB561D2 Gene

SuperPathways for CYB561D2 Gene

No Data Available

Interacting Proteins for CYB561D2 Gene

Selected Interacting proteins: O14569-C56D2_HUMAN for CYB561D2 Gene via MINT I2D

Symbol External ID(s) Details
UNC119

Gene Ontology (GO) - Biological Process for CYB561D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYB561D2: view

No data available for Pathways by source for CYB561D2 Gene

Compounds for CYB561D2 Gene

(1) HMDB Compounds for CYB561D2 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
genes like me logo Genes that share compounds with CYB561D2: view

Transcripts for CYB561D2 Gene

Unigene Clusters for CYB561D2 Gene

Cytochrome b561 family, member D2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYB561D2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYB561D2 Gene

No ASD Table

Relevant External Links for CYB561D2 Gene

GeneLoc Exon Structure for
CYB561D2
ECgene alternative splicing isoforms for
CYB561D2

Expression for CYB561D2 Gene

mRNA expression in normal human tissues for CYB561D2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CYB561D2 Gene

SOURCE GeneReport for Unigene cluster for CYB561D2 Gene Hs.149443

genes like me logo Genes that share expressions with CYB561D2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CYB561D2 Gene

Orthologs for CYB561D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYB561D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYB561D2 35
  • 99.55 (n)
  • 99.55 (a)
cow
(Bos Taurus)
Mammalia CYB561D2 35
  • 89.94 (n)
  • 95.05 (a)
CYB561D2 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 91 (a)
OneToMany
CYB561D2 35
  • 89.49 (n)
  • 94.59 (a)
mouse
(Mus musculus)
Mammalia Cyb561d2 35
  • 89.19 (n)
  • 95.5 (a)
Cyb561d2 16
Cyb561d2 36
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cyb561d2 35
  • 87.84 (n)
  • 95.95 (a)
chicken
(Gallus gallus)
Aves CYB561D2 35
  • 75.17 (n)
  • 75.51 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.32424 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cyb561d2 35
  • 64.1 (n)
  • 64.71 (a)
Str.791 35
zebrafish
(Danio rerio)
Actinopterygii cyb561d2 35
  • 53.39 (n)
  • 52.94 (a)
cyb561d2 36
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3475 36
  • 40 (a)
OneToMany
Species with no ortholog for CYB561D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYB561D2 Gene

ENSEMBL:
Gene Tree for CYB561D2 (if available)
TreeFam:
Gene Tree for CYB561D2 (if available)

Paralogs for CYB561D2 Gene

Paralogs for CYB561D2 Gene

Selected SIMAP similar genes for CYB561D2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CYB561D2: view

Variants for CYB561D2 Gene

Sequence variations from dbSNP and Humsavar for CYB561D2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs34123887 -- 50,353,849(+) GCACT(-/G)GGGAC utr-variant-3-prime, intron-variant
rs35587949 -- 50,354,205(+) GGGCT(A/G)AAGCT intron-variant, downstream-variant-500B
rs35935807 -- 50,353,756(+) CCCAG(-/C)CTAGG utr-variant-3-prime, intron-variant
rs56209704 -- 50,353,167(+) GCTAA(A/G)GGTTA intron-variant
rs58181992 -- 50,354,037(+) AATTT(C/T)AGGAG utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYB561D2 Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897

Relevant External Links for CYB561D2 Gene

HapMap Linkage Disequilibrium report
CYB561D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYB561D2 Gene

Disorders for CYB561D2 Gene

No disorders were found for CYB561D2 Gene.

No data available for UniProtKB/Swiss-Prot for CYB561D2 Gene

Publications for CYB561D2 Gene

  1. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PMID: 11085536) Lerman M.I. … Minna J.D. (Cancer Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Functional expression and characterization of human 101F6 protein, a homologue of cytochrome b561 and a candidate tumor suppressor gene product. (PMID: 19734123) Recuenco M.C. … Tsubaki M. (Biofactors 2008) 3 23
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4
  5. Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PMID: 23249217) Asard H. … BAcrczi A. (Antioxid. Redox Signal. 2013) 2 3

Products for CYB561D2 Gene

Sources for CYB561D2 Gene

Back to Top

Content