CYB561D2 Gene
protein-coding GIFtS: 50
GCID: GC03P050388
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cytochrome b-561 domain containing 2
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Aliases
for CYB561D2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome B-561 Domain Containing 21 2 | | 101F61 2 3 5 | | TSP101 2 | | Putative Tumor Suppressor Protein 101F62 3 | | Cytochrome B561 Domain-Containing Protein 22 | | Putative Tumor Suppressor 101F62 |
Export aliases for CYB561D2 gene to outside databasesPrevious GC identifers: GC03P050348 GC03P050363 |
Summaries
for CYB561D2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CYB561D2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYB561D2 gene promoter:
AP-1 ATF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYB561D2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYB561D2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3CYB561D2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P050388: view genomic region
(about GC identifiers)
Start:
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50,388,126 bp from pter |
End:
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50,395,891 bp from pter |
Size:
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7,766 bases |
Orientation:
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plus strand |
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Proteins
for CYB561D2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C56D2_HUMAN, O14569 (See
protein sequence)Recommended Name: Cytochrome b561 domain-containing protein 2 Size: 222 amino acids; 23974 Da
Cofactor: Binds 2 heme groups non-covalently (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Secondary accessions: A8K552Explore the universe of human proteins at neXtProt for CYB561D2: NX_O14569
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14569
CYB561D2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008953.1
ENSEMBL proteins: ENSP00000400454 ENSP00000410663 ENSP00000232508 ENSP00000391209
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
CYB561D2 for ontologies About GeneDecksing
CYB561D2 Antibody Products:
Assay Products for CYB561D2: |
Protein
Domains /
Families
for CYB561D2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYB561D2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14569ProtoNet protein and cluster: O14569 UniProtKB/Swiss-Prot: C56D2_HUMAN, O14569Similarity: Contains 1 cytochrome b561 domain |
Function
for CYB561D2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB561D2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB561D2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYB561D2 (NM_007022) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYB561D2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB561D2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB561D2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
CYB561D2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CYB561D2:
|
Pathways & Interactions
for CYB561D2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYB561D2
1 Interacting protein for CYB561D2 (O145692, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0022900 | electron transport chain |
IEA | -- |
CYB561D2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYB561D2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CYB561D2
1 HMDB Compound for CYB561D2 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
Search CenterWatch for drugs/clinical trials and news about CYB561D2 / C56D2
|
Transcripts
for CYB561D2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYB561D2 gene: NM_007022.3 Unigene Cluster for CYB561D2: Cytochrome b-561 domain containing 2 Hs.149443 [show with all ESTs]Unigene Representative Sequence: BX6411036 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000425346(uc003dam.3) ENST00000424512 ENST00000232508(uc003dal.3)
ENST00000418577 ENST00000419046 ENST00000490926
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB561D2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB561D2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYB561D2 (NM_007022) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYB561D2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB561D2 |
Additional cDNA sequence: AF040704.1 AK291167.1 BC047691.1 BX641103.1 14 DOTS entries: DT.100884971 DT.91774243 DT.100884950 DT.91842030 DT.101985533 DT.121642948 DT.100884948 DT.109213 DT.91774250 DT.95143048 DT.100884975 DT.120873128 DT.456391 DT.85105475 24/177 AceView cDNA sequences (see all 177): BM829861 BU179244 AA477130 AA421268 BQ225414 CB142328 BE550419 CA488481 AA454950 BM849656 CK725177 AA454561 CA454269 AA235070 AA807710 AI659172 AI738716 BE857589 BG150490 AF040704 BU739316 AI635352 CR598666 BM852873
GeneLoc Exon Structure
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Expression
for CYB561D2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYB561D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCTGGATG
About this image
See CYB561D2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYB561D2
SOURCE GeneReport for Unigene cluster: Hs.149443
SABiosciences Custom PCR Arrays for CYB561D2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYB561D2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYB561D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYB561D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYB561D2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB561D2 |
Orthologs
for CYB561D2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CYB561D2 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for CYB561D2 (if available)
TreeFam Gene Tree for CYB561D2 (if available) |
Paralogs
for CYB561D2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYB561D2 gene
- CYB561D12
1 SIMAP similar gene for CYB561D2 using alignment to 1 protein entry: C56D2_HUMAN:CYB561D1
CYB561D2 for paralogs About GeneDecksing
|
Genomic Variants
for CYB561D2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYB561D2 (50388126 - 50395891 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CYB561D2
3 CNVs: 30176 4335 4336 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYB561D2 |
|
Disorders
/ Diseases
for CYB561D2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYB561D2 for disorders About GeneDecksing
OMIM gene information: 607068
OMIM disorders: --
1  disease for CYB561D2: About MalaCardslung cancer
Export disorders for CYB561D2 gene to outside databases
|
Publications
for CYB561D2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYB561D2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CYB561D2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)1, 2, 3 Lerman M.I. and Minna J.D. (2000)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase. (PubMed id 9122200)1, 3 Townsley F.M.... Ruderman J.V. (1997)
- Functional expression and characterization of human 1 01F6 protein, a homologue of cytochrome b561 and a candidate tumor suppressor g ene product. (PubMed id 19734123)1, 9 Recuenco M.C....Tsubaki M. (2009)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Global profiling of protease cleavage sites by chemos elective labeling of protein N-termini. (PubMed id 19892738)2 Xu G....Jaffrey S.R. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for CYB561D2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CYB561D2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYB561D2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYB561D2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CYB561D2 gene:
Search GeneIP for patents involving CYB561D2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYB561D2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CYB561D2 | | OriGene shRNA RFP for CYB561D2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYB561D2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYB561D2 | | | OriGene Protein Over-expression Lysate for CYB561D2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYB561D2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB561D2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB561D2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYB561D2 | | OriGene Custom Protein Services for CYB561D2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYB561D2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYB561D2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYB561D2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYB561D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYB561D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYB561D2 |
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 | | | CYB561D2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB561D2 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB561D2 |
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