Aliases for CYB561D1 Gene
Aliases for CYB561D1 Gene
External Ids for CYB561D1 Gene
- HGNC: 26804
- Entrez Gene: 284613
- Ensembl: ENSG00000174151
- UniProtKB: Q8N8Q1
Previous GeneCards Identifiers for CYB561D1 Gene
- GC01P109336
- GC01P109749
- GC01P110036
- GC01P107929
Summaries for CYB561D1 Gene
GeneCards Summary for CYB561D1 Gene
CYB561D1 (Cytochrome B561 Family Member D1) is a Protein Coding gene. An important paralog of this gene is CYB561D2.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB561D1 Gene
Genomics for CYB561D1 Gene
Regulatory Elements for CYB561D1 Gene
Enhancers for CYB561D1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CYB561D1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CYB561D1 gene promoter:
Regulatory Element Products
Genomic Location for CYB561D1 Gene
- Chromosome:
- 1
- Start:
- 109,494,036 bp from pter
- End:
- 109,502,932 bp from pter
- Size:
- 8,897 bases
- Orientation:
- Plus strand
Genomic View for CYB561D1 Gene
Genes around CYB561D1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by Ensembl
- 1p13.3 by Entrez Gene
- 1p13.3 by HGNC
CYB561D1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYB561D1 Gene
Proteins for CYB561D1 Gene
-
Protein details for CYB561D1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N8Q1-C56D1_HUMAN
- Recommended name:
- Cytochrome b561 domain-containing protein 1
- Protein Accession:
- Q8N8Q1
- B4DH97
- E9PCM8
- Q52M36
- Q5T6C2
- Q5T6C3
Protein attributes for CYB561D1 Gene
- Size:
- 229 amino acids
- Molecular mass:
- 25424 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYB561D1 Gene
Post-translational modifications for CYB561D1 Gene
Other Protein References for CYB561D1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CYB561D1
- Novus Biologicals Antibodies for CYB561D1
-
Abcam antibodies for CYB561D1
- Invitrogen Antibodies for CYB561D1
- Search GeneTex for Antibodies for CYB561D1
Protein Products
-
OriGene Purified Proteins for CYB561D1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYB561D1
- Origene Custom Protein Services for CYB561D1
- Search GeneTex for Proteins for CYB561D1
Assay Products
No data available for DME Specific Peptides for CYB561D1 Gene
Domains & Families for CYB561D1 Gene
Gene Families for CYB561D1 Gene
- HGNC:
Protein Domains for CYB561D1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYB561D1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CYB561D1 Gene
Function for CYB561D1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CYB561D1 Gene
- GenomeRNAi human phenotypes for CYB561D1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYB561D1
-
- Search ViGene Biosciences for CYB561D1
CRISPR Products
-
OriGene CRISPR knockouts for CYB561D1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYB561D1
- GenScript: Design CRISPR guide RNA sequences for CYB561D1
miRNA for CYB561D1 Gene
- miRTarBase miRNAs that target CYB561D1
-
- hsa-mir-23b-3p (MIRT046314)
- hsa-mir-106a-5p (MIRT048320)
- hsa-mir-519e-5p (MIRT712532)
- hsa-mir-515-5p (MIRT712533)
- hsa-mir-103a-2-5p (MIRT712534)
- hsa-mir-4290 (MIRT712535)
- hsa-mir-1976 (MIRT712536)
- hsa-mir-5695 (MIRT712537)
- hsa-mir-519d-5p (MIRT712538)
- hsa-mir-6893-3p (MIRT712539)
- hsa-mir-370-3p (MIRT712540)
- hsa-mir-660-3p (MIRT712541)
- hsa-mir-4667-3p (MIRT712542)
- hsa-mir-365b-3p (MIRT712543)
- hsa-mir-365a-3p (MIRT712544)
miRNA Products
- Search ViGene Biosciences for CYB561D1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CYB561D1
- Browse OriGene Inhibitory RNA Products For CYB561D1
Clone Products
-
OriGene ORF clones in human for CYB561D1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYB561D1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CYB561D1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYB561D1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CYB561D1
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYB561D1 Gene
Localization for CYB561D1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYB561D1 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for CYB561D1 Gene
No Data Available
Interacting Proteins for CYB561D1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CYB561D1 Gene
Drugs & Compounds for CYB561D1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| heme | Pharma | Agonist | 0 |
Transcripts for CYB561D1 Gene
mRNA/cDNA for CYB561D1 Gene
- (12) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (67) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CYB561D1 Gene
- Cytochrome b561 family, member D1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CYB561D1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYB561D1
- GenScript: Design CRISPR guide RNA sequences for CYB561D1
miRNA Products
- Search ViGene Biosciences for CYB561D1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CYB561D1
- Browse OriGene Inhibitory RNA Products For CYB561D1
Clone Products
-
OriGene ORF clones in human for CYB561D1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYB561D1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CYB561D1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYB561D1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | - | - | - | - |
Expression for CYB561D1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYB561D1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CYB561D1 Gene:
CYB561D1SOURCE GeneReport for Unigene cluster for CYB561D1 Gene:
Hs.514682Evidence on tissue expression from TISSUES for CYB561D1 Gene
- Nervous system(4.3)
- Liver(4)
Primer Products
-
OriGene qPCR primer pairs for CYB561D1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYB561D1 Gene
Orthologs for CYB561D1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CYB561D1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CYB561D1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CYB561D1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cyb561d1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cyb561d1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CYB561D1 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CYB561D1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101734093 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cyb561d1 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3475 35 |
|
OneToMany |
- Species where no ortholog for CYB561D1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CYB561D1 Gene
Paralogs for CYB561D1 Gene
(1) SIMAP similar genes for CYB561D1 Gene using alignment to 5 proteins:
Variants for CYB561D1 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000348149 | -- | 109,497,244(+) | AGGGC(G/T)CAGGT | utr-variant-3-prime | |
| rs1000721964 | -- | 109,492,488(+) | AAGGA(A/G)ATCAA | intron-variant, upstream-variant-2KB | |
| rs1000753328 | -- | 109,492,151(+) | GGCCT(C/T)GAAGG | intron-variant, upstream-variant-2KB | |
| rs1000924584 | -- | 109,497,953(+) | AGAGG(A/G)GTATT | utr-variant-3-prime | |
| rs1000950288 | -- | 109,498,480(+) | GGTCA(A/C)CAGGA | utr-variant-3-prime |
Residual Variation Intolerance Score:
47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.40;
27.59% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CYB561D1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CYB561D1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYB561D1 Gene
Disorders for CYB561D1 Gene
Relevant External Links for CYB561D1
No disorders were found for CYB561D1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB561D1 Gene
Publications for CYB561D1 Gene
- Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PMID: 23249217) Asard H. … BAcrczi A. (Antioxid. Redox Signal. 2013) 2 3 64
- Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3 46 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for CYB561D1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
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- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Flow Cytometry Kits
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- Browse Luminex Assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CYB561D1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CYB561D1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYB561D1
- Origene Custom Protein Services for CYB561D1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CYB561D1
- Browse OriGene Inhibitory RNA Products For CYB561D1
- OriGene qPCR primer pairs for CYB561D1
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for CYB561D1 in any vector
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- GenScript: Design CRISPR guide RNA sequences for CYB561D1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CYB561D1
- Sino Biological Human cDNA Clone for CYB561D1
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies
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- Sino Biological Cell Lysates
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- Novus Biologicals Antibodies for CYB561D1
- Novus Biologicals proteins and lysates for CYB561D1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYB561D1
- VectorBuilder custom plasmid, inducible vectors for CYB561D1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYB561D1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CYB561D1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (127) Disease Ontology
- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer