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Aliases for CYB561D1 Gene

Aliases for CYB561D1 Gene

  • Cytochrome B561 Family Member D1 2 3 5
  • Cytochrome B-561 Domain Containing 1 2
  • Cytochrome B561 Family, Member D1 2

External Ids for CYB561D1 Gene

Previous GeneCards Identifiers for CYB561D1 Gene

  • GC01P109336
  • GC01P109749
  • GC01P110036
  • GC01P107929

Summaries for CYB561D1 Gene

GeneCards Summary for CYB561D1 Gene

CYB561D1 (Cytochrome B561 Family Member D1) is a Protein Coding gene. An important paralog of this gene is CYB561D2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB561D1 Gene

Genomics for CYB561D1 Gene

Regulatory Elements for CYB561D1 Gene

Enhancers for CYB561D1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYB561D1 on UCSC Golden Path with GeneCards custom track

Promoters for CYB561D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYB561D1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CYB561D1 gene promoter:

Genomic Location for CYB561D1 Gene

Chromosome:
1
Start:
109,494,036 bp from pter
End:
109,502,932 bp from pter
Size:
8,897 bases
Orientation:
Plus strand

Genomic View for CYB561D1 Gene

Genes around CYB561D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB561D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB561D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB561D1 Gene

Proteins for CYB561D1 Gene

  • Protein details for CYB561D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8Q1-C56D1_HUMAN
    Recommended name:
    Cytochrome b561 domain-containing protein 1
    Protein Accession:
    Q8N8Q1
    Secondary Accessions:
    • B4DH97
    • E9PCM8
    • Q52M36
    • Q5T6C2
    • Q5T6C3

    Protein attributes for CYB561D1 Gene

    Size:
    229 amino acids
    Molecular mass:
    25424 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYB561D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYB561D1 Gene

Proteomics data for CYB561D1 Gene at MOPED

Post-translational modifications for CYB561D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYB561D1 Gene

Domains & Families for CYB561D1 Gene

Gene Families for CYB561D1 Gene

Protein Domains for CYB561D1 Gene

Suggested Antigen Peptide Sequences for CYB561D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8Q1

UniProtKB/Swiss-Prot:

C56D1_HUMAN :
  • Contains 1 cytochrome b561 domain.
Domain:
  • Contains 1 cytochrome b561 domain.
genes like me logo Genes that share domains with CYB561D1: view

Function for CYB561D1 Gene

genes like me logo Genes that share phenotypes with CYB561D1: view

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYB561D1 Gene

Localization for CYB561D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB561D1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYB561D1 Gene COMPARTMENTS Subcellular localization image for CYB561D1 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for CYB561D1 Gene

Pathways & Interactions for CYB561D1 Gene

SuperPathways for CYB561D1 Gene

No Data Available

Interacting Proteins for CYB561D1 Gene

Gene Ontology (GO) - Biological Process for CYB561D1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CYB561D1 Gene

Drugs & Compounds for CYB561D1 Gene

(1) Drugs for CYB561D1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with CYB561D1: view

Transcripts for CYB561D1 Gene

Unigene Clusters for CYB561D1 Gene

Cytochrome b561 family, member D1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYB561D1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2:
SP3: - - - -

Relevant External Links for CYB561D1 Gene

GeneLoc Exon Structure for
CYB561D1
ECgene alternative splicing isoforms for
CYB561D1

Expression for CYB561D1 Gene

mRNA expression in normal human tissues for CYB561D1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CYB561D1 Gene



SOURCE GeneReport for Unigene cluster for CYB561D1 Gene Hs.514682

genes like me logo Genes that share expression patterns with CYB561D1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CYB561D1 Gene

Orthologs for CYB561D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYB561D1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYB561D1 35
  • 91.99 (n)
  • 93.45 (a)
CYB561D1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYB561D1 35
  • 90.68 (n)
  • 91.7 (a)
CYB561D1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyb561d1 35
  • 90.25 (n)
  • 90.39 (a)
Cyb561d1 16
Cyb561d1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYB561D1 35
  • 99.56 (n)
  • 99.56 (a)
CYB561D1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyb561d1 35
  • 90.25 (n)
  • 89.52 (a)
oppossum
(Monodelphis domestica)
Mammalia CYB561D1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYB561D1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734093 35
  • 61.16 (n)
  • 64.62 (a)
zebrafish
(Danio rerio)
Actinopterygii cyb561d1 35
  • 56.49 (n)
  • 50.44 (a)
cyb561d1 36
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3475 36
  • 35 (a)
OneToMany
Species with no ortholog for CYB561D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYB561D1 Gene

ENSEMBL:
Gene Tree for CYB561D1 (if available)
TreeFam:
Gene Tree for CYB561D1 (if available)

Paralogs for CYB561D1 Gene

Paralogs for CYB561D1 Gene

(1) SIMAP similar genes for CYB561D1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CYB561D1: view

Variants for CYB561D1 Gene

Sequence variations from dbSNP and Humsavar for CYB561D1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs749056 -- 109,495,216(+) GGTAT(G/T)CCTCA intron-variant
rs1043274 -- 109,499,822(+) CCTCA(C/T)CTTCC utr-variant-3-prime
rs1149171 -- 109,493,840(+) GCCAC(A/G)AAAGT upstream-variant-2KB
rs1278847 -- 109,494,861(-) ttttt(G/T)gttgt intron-variant
rs1278848 -- 109,498,857(-) TTTTT(A/T)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CYB561D1 Gene

Variant ID Type Subtype PubMed ID
nsv872141 CNV Loss 21882294

Variation tolerance for CYB561D1 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CYB561D1 Gene

Disorders for CYB561D1 Gene

Relevant External Links for CYB561D1

Genetic Association Database (GAD)
CYB561D1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYB561D1

No disorders were found for CYB561D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB561D1 Gene

Publications for CYB561D1 Gene

  1. Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PMID: 23249217) Asard H. … BAcrczi A. (Antioxid. Redox Signal. 2013) 2 3 67
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  3. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3
  4. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CYB561D1 Gene

Sources for CYB561D1 Gene

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