Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYB561A3 Gene

Aliases for CYB561A3 Gene

  • Cytochrome B561 Family, Member A3 2 3
  • Cytochrome B, Ascorbate Dependent 3 2 3
  • Cytochrome B561 Family Member A3 3 4
  • Lysosomal Cytochrome B 3 4
  • CYBASC3 3 4
  • LCYTB 3 4
  • Cytochrome B Ascorbate-Dependent Protein 3 3
  • EC 1.-.-.- 4

External Ids for CYB561A3 Gene

Previous Symbols for CYB561A3 Gene

  • CYBASC3

Summaries for CYB561A3 Gene

GeneCards Summary for CYB561A3 Gene

CYB561A3 (Cytochrome B561 Family, Member A3) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is CYB561.

UniProtKB/Swiss-Prot for CYB561A3 Gene

  • Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB561A3 Gene

Genomics for CYB561A3 Gene

Genomic Location for CYB561A3 Gene

Start:
61,348,745 bp from pter
End:
61,362,299 bp from pter
Size:
13,555 bases
Orientation:
Minus strand

Genomic View for CYB561A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYB561A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB561A3 Gene

No data available for Regulatory Elements for CYB561A3 Gene

Proteins for CYB561A3 Gene

  • Protein details for CYB561A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBI2-CYAC3_HUMAN
    Recommended name:
    Cytochrome b ascorbate-dependent protein 3
    Protein Accession:
    Q8NBI2
    Secondary Accessions:
    • B3KPU2
    • B4DLN9
    • J3KQH4
    • Q6PK96

    Protein attributes for CYB561A3 Gene

    Size:
    242 amino acids
    Molecular mass:
    27214 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 2 heme groups non-covalently.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYB561A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYB561A3 Gene

Proteomics data for CYB561A3 Gene at MOPED

Post-translational modifications for CYB561A3 Gene

No data available for DME Specific Peptides for CYB561A3 Gene

Domains for CYB561A3 Gene

Gene Families for CYB561A3 Gene

HGNC:
  • CYB :Cytochrome b genes

Protein Domains for CYB561A3 Gene

UniProtKB/Swiss-Prot:

CYAC3_HUMAN
Domain:
  • Contains 1 cytochrome b561 domain.:
    • Q8NBI2
genes like me logo Genes that share domains with CYB561A3: view

Function for CYB561A3 Gene

Molecular function for CYB561A3 Gene

UniProtKB/Swiss-Prot Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).

Enzyme Numbers (IUBMB) for CYB561A3 Gene

Gene Ontology (GO) - Molecular Function for CYB561A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYB561A3: view

Phenotypes for CYB561A3 Gene

GenomeRNAi human phenotypes for CYB561A3:
genes like me logo Genes that share phenotypes with CYB561A3: view

miRNA for CYB561A3 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CYB561A3 Gene

Localization for CYB561A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB561A3 Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for CYB561A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome --
GO:0005765 lysosomal membrane ISS --
GO:0016021 integral component of membrane IEA --
GO:0031902 late endosome membrane ISS --
genes like me logo Genes that share ontologies with CYB561A3: view

Pathways for CYB561A3 Gene

SuperPathways for CYB561A3 Gene

No Data Available

Interacting Proteins for CYB561A3 Gene

Selected Interacting proteins: Q8NBI2-CYAC3_HUMAN for CYB561A3 Gene via UniProtKB

Symbol External ID(s) Details
RNF5

Gene Ontology (GO) - Biological Process for CYB561A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYB561A3: view

No data available for Pathways by source for CYB561A3 Gene

Transcripts for CYB561A3 Gene

Unigene Clusters for CYB561A3 Gene

Cytochrome b561 family, member A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYB561A3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11 ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - - -
SP10: - - - - - - - - -
SP11: - - -
SP12: -
SP13: - - - - - - - - -

ExUns: 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CYB561A3 Gene

GeneLoc Exon Structure for
CYB561A3
ECgene alternative splicing isoforms for
CYB561A3

Expression for CYB561A3 Gene

mRNA expression in normal human tissues for CYB561A3 Gene

mRNA differential expression in normal tissues according to GTEx for CYB561A3 Gene

This gene is overexpressed in Adrenal Gland (10.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CYB561A3 Gene

SOURCE GeneReport for Unigene cluster for CYB561A3 Gene Hs.22546

genes like me logo Genes that share expressions with CYB561A3: view

Orthologs for CYB561A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB561A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYB561A3 37
  • 100 (a)
OneToOne
LOC451235 36
  • 99.74 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CYB561A3 36
  • 82.23 (n)
  • 78.93 (a)
CYB561A3 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYB561A3 37
  • 74 (a)
OneToOne
CYBASC3 36
  • 81.4 (n)
  • 76.45 (a)
mouse
(Mus musculus)
Mammalia Cyb561a3 36
  • 83.88 (n)
  • 84.71 (a)
Cyb561a3 37
  • 84 (a)
OneToOne
Cybasc3 16
oppossum
(Monodelphis domestica)
Mammalia CYB561A3 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYB561A3 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyb561a3 36
  • 83.26 (n)
  • 83.83 (a)
chicken
(Gallus gallus)
Aves CYBASC3 36
  • 68.8 (n)
  • 65.3 (a)
CYBASC3 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYB561A3 37
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cyb561a3a 36
  • 56.88 (n)
  • 58.72 (a)
cyb561a3a 37
  • 55 (a)
OneToMany
cyb561a3b 37
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1275 37
  • 26 (a)
ManyToMany
nemy 37
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F39G3.4 37
  • 17 (a)
ManyToMany
F39G3.5 37
  • 23 (a)
ManyToMany
F55H2.5 37
  • 27 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYB-1 36
  • 46.48 (n)
  • 41.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToMany
Species with no ortholog for CYB561A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYB561A3 Gene

ENSEMBL:
Gene Tree for CYB561A3 (if available)
TreeFam:
Gene Tree for CYB561A3 (if available)

Paralogs for CYB561A3 Gene

Paralogs for CYB561A3 Gene

genes like me logo Genes that share paralogs with CYB561A3: view

Variants for CYB561A3 Gene

Sequence variations from dbSNP and Humsavar for CYB561A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2290388 -- 61,356,831(+) GGAAT(A/C)TTTTT utr-variant-5-prime, intron-variant
rs4939517 -- 61,359,386(+) AATTC(C/T)TCCAA intron-variant
rs7951574 -- 61,355,406(+) tgggc(A/G)cagtg intron-variant
rs10792312 -- 61,354,869(+) TCTTT(C/T)TTTTT intron-variant
rs11230673 -- 61,355,921(+) tgtct(C/T)tacta intron-variant

Relevant External Links for CYB561A3 Gene

HapMap Linkage Disequilibrium report
CYB561A3

No data available for Structural Variations from Database of Genomic Variants (DGV) for CYB561A3 Gene

Disorders for CYB561A3 Gene

No disorders were found for CYB561A3 Gene.

No data available for UniProtKB/Swiss-Prot for CYB561A3 Gene

Publications for CYB561A3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3 4
  4. Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PMID: 23249217) Asard H. … BAcrczi A. (Antioxid. Redox Signal. 2013) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CYB561A3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYB561A3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYB561A3
    • Block miRNA regulation of CYB561A3 using miScript Target Protectors

    Sources for CYB561A3 Gene

    Back to Top

    Content