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Aliases for CYB561A3 Gene

Aliases for CYB561A3 Gene

  • Cytochrome B561 Family Member A3 2 3 4 5
  • Cytochrome B, Ascorbate Dependent 3 2 3
  • Lysosomal Cytochrome B 3 4
  • CYBASC3 3 4
  • LCYTB 3 4
  • Cytochrome B Ascorbate-Dependent Protein 3 3
  • Cytochrome B561 Family, Member A3 2
  • EC 1.-.-.- 4

External Ids for CYB561A3 Gene

Previous HGNC Symbols for CYB561A3 Gene

  • CYBASC3

Previous GeneCards Identifiers for CYB561A3 Gene

  • GC11M061117

Summaries for CYB561A3 Gene

GeneCards Summary for CYB561A3 Gene

CYB561A3 (Cytochrome B561 Family Member A3) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is CYBRD1.

UniProtKB/Swiss-Prot for CYB561A3 Gene

  • Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB561A3 Gene

Genomics for CYB561A3 Gene

Regulatory Elements for CYB561A3 Gene

Enhancers for CYB561A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F061826 1.1 FANTOM5 ENCODE 11.5 -470.1 -470071 12.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YY1 ZNF143 FOS FADS2 INTS5 NXF1 UBXN1 METTL12 MTA2 FADS1 TMEM138 EML3 TMEM109
GH11F061693 1.2 FANTOM5 Ensembl ENCODE 7.6 -336.2 -336203 9.8 PKNOX1 SIN3A FOS DEK ZNF263 REST SMARCB1 ZNF592 NFIL3 MAFF MYRF DKFZP434K028 DAGLA SYT7 FTH1 CYB561A3 VWCE SDHAF2 DDB1 LBHD1
GH11F061377 1.4 FANTOM5 Ensembl ENCODE 7.2 -16.6 -16605 2.9 BCOR JUN ZMYM3 CEBPG RFX5 YY1 ZFHX2 ADNP SCRT2 HNF4G DDB1 TKFC DAGLA CYB561A3 SDHAF2 VPS37C CPSF7 SLC15A3 TMEM138 GC11P061375
GH11F061167 0.8 FANTOM5 Ensembl ENCODE 5.5 +194.2 194226 1.9 HDGF BCOR TBP PKNOX1 ZMYM3 RELA ZNF316 EGR1 POLR2A EED CD5 SLC15A3 CYB561A3 CPSF7 SDHAF2 VPS37C TMEM138 GC11P061168 PGA3
GH11F061344 0.9 ENCODE 5.2 +14.8 14846 6.1 ZNF207 ETV6 EGR2 REST NR2F2 ZNF589 KDM1A MYC ZNF18 SALL1 TMEM216 SDHAF2 CYB561A3 LOC101927495 DDB1 ENSG00000279246
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CYB561A3 on UCSC Golden Path with GeneCards custom track

Promoters for CYB561A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109496 99 3201 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for CYB561A3 Gene

Chromosome:
11
Start:
61,348,745 bp from pter
End:
61,362,299 bp from pter
Size:
13,555 bases
Orientation:
Minus strand

Genomic View for CYB561A3 Gene

Genes around CYB561A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB561A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB561A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB561A3 Gene

Proteins for CYB561A3 Gene

  • Protein details for CYB561A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBI2-CYAC3_HUMAN
    Recommended name:
    Cytochrome b ascorbate-dependent protein 3
    Protein Accession:
    Q8NBI2
    Secondary Accessions:
    • B3KPU2
    • B4DLN9
    • J3KQH4
    • Q6PK96

    Protein attributes for CYB561A3 Gene

    Size:
    242 amino acids
    Molecular mass:
    27214 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYB561A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYB561A3 Gene

Post-translational modifications for CYB561A3 Gene

No data available for DME Specific Peptides for CYB561A3 Gene

Domains & Families for CYB561A3 Gene

Gene Families for CYB561A3 Gene

Protein Domains for CYB561A3 Gene

Suggested Antigen Peptide Sequences for CYB561A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBI2

UniProtKB/Swiss-Prot:

CYAC3_HUMAN :
  • Contains 1 cytochrome b561 domain.
Domain:
  • Contains 1 cytochrome b561 domain.
genes like me logo Genes that share domains with CYB561A3: view

Function for CYB561A3 Gene

Molecular function for CYB561A3 Gene

UniProtKB/Swiss-Prot Function:
Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity).

Enzyme Numbers (IUBMB) for CYB561A3 Gene

Gene Ontology (GO) - Molecular Function for CYB561A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYB561A3: view
genes like me logo Genes that share phenotypes with CYB561A3: view

Animal Models for CYB561A3 Gene

MGI Knock Outs for CYB561A3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYB561A3 Gene

Localization for CYB561A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB561A3 Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for CYB561A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane ISS --
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYB561A3: view

No data available for Subcellular locations from COMPARTMENTS for CYB561A3 Gene

Pathways & Interactions for CYB561A3 Gene

SuperPathways for CYB561A3 Gene

No Data Available

Interacting Proteins for CYB561A3 Gene

Selected Interacting proteins: Q8NBI2-CYAC3_HUMAN for CYB561A3 Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for CYB561A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA,IBA --
genes like me logo Genes that share ontologies with CYB561A3: view

No data available for Pathways by source and SIGNOR curated interactions for CYB561A3 Gene

Transcripts for CYB561A3 Gene

Unigene Clusters for CYB561A3 Gene

Cytochrome b561 family, member A3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYB561A3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11 ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - - -
SP10: - - - - - - - - -
SP11: - - -
SP12: -
SP13: - - - - - - - - -

ExUns: 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CYB561A3 Gene

GeneLoc Exon Structure for
CYB561A3
ECgene alternative splicing isoforms for
CYB561A3

Expression for CYB561A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYB561A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYB561A3 Gene

This gene is overexpressed in Adrenal Gland (x10.2).

Protein differential expression in normal tissues from HIPED for CYB561A3 Gene

This gene is overexpressed in Blymphocyte (32.4), Lymph node (28.6), and Monocytes (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYB561A3 Gene



Protein tissue co-expression partners for CYB561A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYB561A3 Gene:

CYB561A3

SOURCE GeneReport for Unigene cluster for CYB561A3 Gene:

Hs.22546
genes like me logo Genes that share expression patterns with CYB561A3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CYB561A3 Gene

Orthologs for CYB561A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB561A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYB561A3 35
  • 100 (a)
OneToOne
LOC451235 34
  • 99.74 (n)
mouse
(Mus musculus)
Mammalia Cyb561a3 34 16 35
  • 83.88 (n)
rat
(Rattus norvegicus)
Mammalia Cyb561a3 34
  • 83.26 (n)
cow
(Bos Taurus)
Mammalia CYB561A3 34 35
  • 82.23 (n)
dog
(Canis familiaris)
Mammalia CYBASC3 34
  • 81.4 (n)
CYB561A3 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYB561A3 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYB561A3 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYBASC3 34 35
  • 68.8 (n)
lizard
(Anolis carolinensis)
Reptilia CYB561A3 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cyb561a3a 34 35
  • 56.88 (n)
cyb561a3b 35
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1275 35
  • 26 (a)
ManyToMany
nemy 35
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F55H2.5 35
  • 27 (a)
ManyToMany
F39G3.5 35
  • 23 (a)
ManyToMany
F39G3.4 35
  • 17 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYB-1 34
  • 46.48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for CYB561A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYB561A3 Gene

ENSEMBL:
Gene Tree for CYB561A3 (if available)
TreeFam:
Gene Tree for CYB561A3 (if available)

Paralogs for CYB561A3 Gene

Paralogs for CYB561A3 Gene

genes like me logo Genes that share paralogs with CYB561A3: view

Variants for CYB561A3 Gene

Sequence variations from dbSNP and Humsavar for CYB561A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1009865 -- 61,353,922(-) GCAGC(A/C/G)CTGCA nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, utr-variant-5-prime
rs1009866 -- 61,353,729(-) GGTTG(G/T)GGGTT intron-variant, downstream-variant-500B
rs1045890 -- 61,349,753(-) GGGAG(C/T)GGCGG intron-variant, utr-variant-3-prime
rs10792312 -- 61,354,869(+) TCTTT(C/T)TTTTT intron-variant
rs111693851 -- 61,350,181(+) CGGCC(A/G)GAGAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CYB561A3 Gene

Variant ID Type Subtype PubMed ID
nsv428259 CNV gain+loss 18775914
nsv832177 CNV loss 17160897

Variation tolerance for CYB561A3 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYB561A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYB561A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYB561A3 Gene

Disorders for CYB561A3 Gene

Relevant External Links for CYB561A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYB561A3

No disorders were found for CYB561A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB561A3 Gene

Publications for CYB561A3 Gene

  1. Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PMID: 23249217) Asard H. … BAcrczi A. (Antioxid. Redox Signal. 2013) 2 3 64
  2. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3 4 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for CYB561A3 Gene

Sources for CYB561A3 Gene

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