Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYB561 Gene

Aliases for CYB561 Gene

  • Cytochrome B561 2 3 5
  • Ferric-Chelate Reductase 2 2 3
  • Cytochrome B-561 3 4
  • Cytochrome B561 Family, Member A1 3
  • Cytochrome B561 Family 2
  • Member A1 2
  • CYB561A1 3
  • FRRS2 3

External Ids for CYB561 Gene

Previous GeneCards Identifiers for CYB561 Gene

  • GC17M061161
  • GC17M063936
  • GC17M061850
  • GC17M061983
  • GC17M058863
  • GC17M061509
  • GC17M056878

Summaries for CYB561 Gene

GeneCards Summary for CYB561 Gene

CYB561 (Cytochrome B561) is a Protein Coding gene. GO annotations related to this gene include ferric-chelate reductase activity and transmembrane electron transfer carrier. An important paralog of this gene is CYB561A3.

UniProtKB/Swiss-Prot for CYB561 Gene

  • Secretory vesicle-specific electron transport protein.

Gene Wiki entry for CYB561 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB561 Gene

Genomics for CYB561 Gene

Regulatory Elements for CYB561 Gene

Promoters for CYB561 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYB561 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYB561 Gene

Chromosome:
17
Start:
63,432,304 bp from pter
End:
63,446,378 bp from pter
Size:
14,075 bases
Orientation:
Minus strand

Genomic View for CYB561 Gene

Genes around CYB561 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB561 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB561 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB561 Gene

Proteins for CYB561 Gene

  • Protein details for CYB561 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49447-CY561_HUMAN
    Recommended name:
    Cytochrome b561
    Protein Accession:
    P49447
    Secondary Accessions:
    • B2RE96
    • B7Z775
    • D3DU11
    • Q5BJG9
    • Q9BU05
    • Q9BWR9

    Protein attributes for CYB561 Gene

    Size:
    251 amino acids
    Molecular mass:
    27559 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYB561 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYB561 Gene

Proteomics data for CYB561 Gene at MOPED

Post-translational modifications for CYB561 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYB561 Gene

Domains & Families for CYB561 Gene

Gene Families for CYB561 Gene

Suggested Antigen Peptide Sequences for CYB561 Gene

Graphical View of Domain Structure for InterPro Entry

P49447

UniProtKB/Swiss-Prot:

CY561_HUMAN :
  • Contains 1 cytochrome b561 domain.
Domain:
  • Contains 1 cytochrome b561 domain.
genes like me logo Genes that share domains with CYB561: view

Function for CYB561 Gene

Molecular function for CYB561 Gene

GENATLAS Biochemistry:
cytochrome b561 (30kDaA), specific to catecholamine and neuropeptide secretory vesicles of neuroendocrine tissues
UniProtKB/Swiss-Prot Function:
Secretory vesicle-specific electron transport protein.

Gene Ontology (GO) - Molecular Function for CYB561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYB561: view
genes like me logo Genes that share phenotypes with CYB561: view

Animal Models for CYB561 Gene

MGI Knock Outs for CYB561:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYB561 Gene

Localization for CYB561 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB561 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYB561 Gene COMPARTMENTS Subcellular localization image for CYB561 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CYB561 Gene

Pathways & Interactions for CYB561 Gene

SuperPathways for CYB561 Gene

No Data Available

Interacting Proteins for CYB561 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354028%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000363680%0d%0a
Selected Interacting proteins: P49447-CY561_HUMAN ENSP00000354028 for CYB561 Gene via UniProtKB I2D STRING

Gene Ontology (GO) - Biological Process for CYB561 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CYB561 Gene

Drugs & Compounds for CYB561 Gene

(5) Drugs for CYB561 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(5) Additional Compounds for CYB561 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CYB561: view

Transcripts for CYB561 Gene

mRNA/cDNA for CYB561 Gene

Unigene Clusters for CYB561 Gene

Cytochrome b561:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYB561 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ·
SP1: - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - -
SP16:
SP17:
SP18: - - - - - -

ExUns: 11c ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k ^ 13
SP1: -
SP2: -
SP3: -
SP4: - - - - - - - - - - -
SP5: -
SP6: -
SP7: -
SP8: -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:

Relevant External Links for CYB561 Gene

GeneLoc Exon Structure for
CYB561
ECgene alternative splicing isoforms for
CYB561

Expression for CYB561 Gene

mRNA expression in normal human tissues for CYB561 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYB561 Gene

This gene is overexpressed in Pancreas (x4.4).

Protein differential expression in normal tissues from HIPED for CYB561 Gene

This gene is overexpressed in Nasal epithelium (36.8) and Oral epithelium (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYB561 Gene



SOURCE GeneReport for Unigene cluster for CYB561 Gene Hs.355264

genes like me logo Genes that share expression patterns with CYB561: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CYB561 Gene

Orthologs for CYB561 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB561 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYB561 35
  • 86.59 (n)
  • 86.85 (a)
CYB561 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYB561 35
  • 87.92 (n)
  • 89.24 (a)
CYB561 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyb561 35
  • 86.36 (n)
  • 90.3 (a)
Cyb561 16
Cyb561 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYB561 35
  • 99.07 (n)
  • 98.8 (a)
CYB561 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyb561 35
  • 84.53 (n)
  • 89.03 (a)
oppossum
(Monodelphis domestica)
Mammalia CYB561 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYB561 35
  • 73.65 (n)
  • 70.51 (a)
CYB561 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyb561 35
  • 61.37 (n)
  • 60.94 (a)
Str.125 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.27548 35
zebrafish
(Danio rerio)
Actinopterygii cyb561 35
  • 61.58 (n)
  • 60.59 (a)
cyb561 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1275 37
  • 38 (a)
CG1275 36
  • 26 (a)
ManyToMany
nemy 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F55H2.5 37
  • 36 (a)
CELE_F55H2.5 35
  • 46.38 (n)
  • 40.57 (a)
F39G3.4 36
  • 18 (a)
ManyToMany
F39G3.5 36
  • 23 (a)
ManyToMany
F55H2.5 36
  • 31 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ACYB-2 35
  • 46.58 (n)
  • 37.44 (a)
rice
(Oryza sativa)
Liliopsida Os10g0504200 35
  • 48.92 (n)
  • 40.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for CYB561:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYB561 Gene

ENSEMBL:
Gene Tree for CYB561 (if available)
TreeFam:
Gene Tree for CYB561 (if available)

Paralogs for CYB561 Gene

Paralogs for CYB561 Gene

genes like me logo Genes that share paralogs with CYB561: view

Variants for CYB561 Gene

Sequence variations from dbSNP and Humsavar for CYB561 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs6936 -- 63,432,305(+) TTTTT(A/C)TGCTG utr-variant-3-prime
rs10685 -- 63,432,365(-) GCCAA(C/T)CTTCT utr-variant-3-prime
rs11966 -- 63,432,306(+) TTTTC(G/T)GCTGT utr-variant-3-prime
rs14902 -- 63,432,340(-) GCTGT(C/T)GGTGC utr-variant-3-prime
rs875417 -- 63,447,803(+) CCCTT(C/G)CAAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYB561 Gene

Variant ID Type Subtype PubMed ID
nsv908682 CNV Loss 21882294

Variation tolerance for CYB561 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYB561 Gene

HapMap Linkage Disequilibrium report
CYB561

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYB561 Gene

Disorders for CYB561 Gene

Relevant External Links for CYB561

Genetic Association Database (GAD)
CYB561
Human Genome Epidemiology (HuGE) Navigator
CYB561
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYB561

No disorders were found for CYB561 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB561 Gene

Publications for CYB561 Gene

  1. Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane. (PMID: 7559396) Srivastava M. (J. Biol. Chem. 1995) 3 4 23 67
  2. The human cytochrome b561 gene (CYB561) is located at 17q11-qter. (PMID: 7959749) McBride O.W. … Srivastava M. (Genomics 1994) 2 3 23
  3. Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PMID: 23249217) Asard H. … BAcrczi A. (Antioxid. Redox Signal. 2013) 2 3
  4. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. (PMID: 18180394) Fung M.M. … O'Connor D.T. (Circulation 2008) 3 23
  5. Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information. (PMID: 7980462) Srivastava M. … Fleming P.J. (Biochem. J. 1994) 3 23

Products for CYB561 Gene

Sources for CYB561 Gene

Back to Top

Content