Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYB561 Gene

Aliases for CYB561 Gene

  • Cytochrome B561 2 3 5
  • Cytochrome B561 Family, Member A1 2 3
  • Ferric-Chelate Reductase 2 2 3
  • Cytochrome B-561 3 4
  • CYB561A1 3
  • FRRS2 3

External Ids for CYB561 Gene

Previous GeneCards Identifiers for CYB561 Gene

  • GC17M061161
  • GC17M063936
  • GC17M061850
  • GC17M061983
  • GC17M058863
  • GC17M061509
  • GC17M056878

Summaries for CYB561 Gene

GeneCards Summary for CYB561 Gene

CYB561 (Cytochrome B561) is a Protein Coding gene. GO annotations related to this gene include ferric-chelate reductase activity and transmembrane electron transfer carrier. An important paralog of this gene is CYB561A3.

UniProtKB/Swiss-Prot for CYB561 Gene

  • Secretory vesicle-specific electron transport protein.

Gene Wiki entry for CYB561 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB561 Gene

Genomics for CYB561 Gene

Regulatory Elements for CYB561 Gene

Enhancers for CYB561 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G063431 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23 +11.9 11851 6.6 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 CYB561 LOC342541 ACE TACO1 DDX42 SMARCD2 PIR45110 ENSG00000265282
GH17G063273 1.6 FANTOM5 Ensembl ENCODE 23.4 +170.5 170510 4.8 PKNOX1 FOXA2 INSM2 NFXL1 ZNF48 RAD21 ZEB1 RFX5 GATA2 ZNF366 CYB561 ENSG00000265282 TANC2 KCNH6 MAP3K3 LIMD2 GC17M063258 GC17P063302
GH17G063438 1.2 Ensembl ENCODE dbSUPER 30.6 +6.5 6548 2.5 CTCF KLF1 PKNOX1 NFXL1 YY1 HIC1 SCRT2 ETV6 BCLAF1 MAFK CYB561 ENSG00000265971 GC17M063420 GC17P063438
GH17G063460 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.3 -14.4 -14406 1.5 PKNOX1 ARNT SIN3A TCF12 ZNF766 GATA2 ZNF207 FOS KLF13 CAVIN1 CYB561 MAP3K3 FTSJ3 GC17P063465 ENSG00000265971
GH17G063427 1.1 ENCODE dbSUPER 28.1 +18.0 18049 0.8 ELF3 FOXA2 MLX ARID4B SIN3A NFXL1 RAD21 ZNF366 ETV6 MIXL1 CYB561 LOC342541 ACE TACO1 ENSG00000263644 LOC105371856
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYB561 on UCSC Golden Path with GeneCards custom track

Promoters for CYB561 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096802 178 1601 HDGF ARNT SIN3A DMAP1 ZBTB7B YY1 ZNF207 FOS ZHX2 REST

Genomic Location for CYB561 Gene

Chromosome:
17
Start:
63,432,304 bp from pter
End:
63,446,378 bp from pter
Size:
14,075 bases
Orientation:
Minus strand

Genomic View for CYB561 Gene

Genes around CYB561 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB561 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB561 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB561 Gene

Proteins for CYB561 Gene

  • Protein details for CYB561 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49447-CY561_HUMAN
    Recommended name:
    Cytochrome b561
    Protein Accession:
    P49447
    Secondary Accessions:
    • B2RE96
    • B7Z775
    • D3DU11
    • Q5BJG9
    • Q9BU05
    • Q9BWR9

    Protein attributes for CYB561 Gene

    Size:
    251 amino acids
    Molecular mass:
    27559 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYB561 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYB561 Gene

Post-translational modifications for CYB561 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYB561 Gene

Domains & Families for CYB561 Gene

Gene Families for CYB561 Gene

Suggested Antigen Peptide Sequences for CYB561 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CYB561: view

No data available for UniProtKB/Swiss-Prot for CYB561 Gene

Function for CYB561 Gene

Molecular function for CYB561 Gene

GENATLAS Biochemistry:
cytochrome b561 (30kDaA), specific to catecholamine and neuropeptide secretory vesicles of neuroendocrine tissues
UniProtKB/Swiss-Prot Function:
Secretory vesicle-specific electron transport protein.

Gene Ontology (GO) - Molecular Function for CYB561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000293 ferric-chelate reductase activity ISS 14499595
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IBA --
GO:0022865 transmembrane electron transfer carrier NAS 7559396
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYB561: view
genes like me logo Genes that share phenotypes with CYB561: view

Animal Models for CYB561 Gene

MGI Knock Outs for CYB561:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYB561

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYB561 Gene

Localization for CYB561 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB561 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYB561 gene
Compartment Confidence
plasma membrane 3
lysosome 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CYB561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 7559396
genes like me logo Genes that share ontologies with CYB561: view

Pathways & Interactions for CYB561 Gene

SuperPathways for CYB561 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CYB561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022900 electron transport chain NAS 7559396
GO:0055085 transmembrane transport IEA --
GO:0055114 oxidation-reduction process IBA,IEA --
genes like me logo Genes that share ontologies with CYB561: view

No data available for Pathways by source and SIGNOR curated interactions for CYB561 Gene

Drugs & Compounds for CYB561 Gene

(5) Drugs for CYB561 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(5) Additional Compounds for CYB561 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CYB561: view

Transcripts for CYB561 Gene

mRNA/cDNA for CYB561 Gene

Unigene Clusters for CYB561 Gene

Cytochrome b561:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYB561 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ·
SP1: - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - -
SP16:
SP17:
SP18: - - - - - -

ExUns: 11c ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k ^ 13
SP1: -
SP2: -
SP3: -
SP4: - - - - - - - - - - -
SP5: -
SP6: -
SP7: -
SP8: -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:

Relevant External Links for CYB561 Gene

GeneLoc Exon Structure for
CYB561
ECgene alternative splicing isoforms for
CYB561

Expression for CYB561 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYB561 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYB561 Gene

This gene is overexpressed in Pancreas (x4.4).

Protein differential expression in normal tissues from HIPED for CYB561 Gene

This gene is overexpressed in Nasal epithelium (36.8) and Oral epithelium (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYB561 Gene



NURSA nuclear receptor signaling pathways regulating expression of CYB561 Gene:

CYB561

SOURCE GeneReport for Unigene cluster for CYB561 Gene:

Hs.355264

Evidence on tissue expression from TISSUES for CYB561 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Blood(4)
  • Adrenal gland(3.1)
genes like me logo Genes that share expression patterns with CYB561: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYB561 Gene

Orthologs for CYB561 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB561 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYB561 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia CYB561 34 35
  • 87.92 (n)
cow
(Bos Taurus)
Mammalia CYB561 34 35
  • 86.59 (n)
mouse
(Mus musculus)
Mammalia Cyb561 34 16 35
  • 86.36 (n)
rat
(Rattus norvegicus)
Mammalia Cyb561 34
  • 84.53 (n)
oppossum
(Monodelphis domestica)
Mammalia CYB561 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYB561 34 35
  • 73.65 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyb561 34
  • 61.37 (n)
Str.125 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.27548 34
zebrafish
(Danio rerio)
Actinopterygii cyb561 34 35
  • 61.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1275 36 35
  • 38 (a)
nemy 35
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_F55H2.5 34
  • 46.38 (n)
F55H2.5 36 35
  • 36 (a)
F39G3.5 35
  • 23 (a)
ManyToMany
F39G3.4 35
  • 18 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ACYB-2 34
  • 46.58 (n)
rice
(Oryza sativa)
Liliopsida Os10g0504200 34
  • 48.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for CYB561 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYB561 Gene

ENSEMBL:
Gene Tree for CYB561 (if available)
TreeFam:
Gene Tree for CYB561 (if available)

Paralogs for CYB561 Gene

Paralogs for CYB561 Gene

genes like me logo Genes that share paralogs with CYB561: view

Variants for CYB561 Gene

Sequence variations from dbSNP and Humsavar for CYB561 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000120366 -- 63,435,393(+) GGGAG(A/G)AGCAC intron-variant
rs1000227198 -- 63,446,091(+) GGCGC(C/T)GCAGT intron-variant, utr-variant-5-prime
rs1000459879 -- 63,447,809(+) CAAAG(C/T)CAGGA upstream-variant-2KB
rs1000629204 -- 63,439,135(+) TGCAG(G/T)GCCCA intron-variant, upstream-variant-2KB
rs1000827729 -- 63,444,689(+) TCTGT(A/G)ACATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYB561 Gene

Variant ID Type Subtype PubMed ID
nsv1064059 CNV gain 25217958
nsv952354 CNV deletion 24416366

Variation tolerance for CYB561 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYB561 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYB561

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYB561 Gene

Disorders for CYB561 Gene

Relevant External Links for CYB561

Genetic Association Database (GAD)
CYB561
Human Genome Epidemiology (HuGE) Navigator
CYB561
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYB561

No disorders were found for CYB561 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB561 Gene

Publications for CYB561 Gene

  1. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. (PMID: 18180394) Fung M.M. … O'Connor D.T. (Circulation 2008) 3 22 46 64
  2. Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane. (PMID: 7559396) Srivastava M. (J. Biol. Chem. 1995) 3 4 22 64
  3. The human cytochrome b561 gene (CYB561) is located at 17q11-qter. (PMID: 7959749) McBride O.W. … Srivastava M. (Genomics 1994) 2 3 22 64
  4. Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information. (PMID: 7980462) Srivastava M. … Fleming P.J. (Biochem. J. 1994) 3 4 22 64
  5. Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PMID: 23249217) Asard H. … BAcrczi A. (Antioxid. Redox Signal. 2013) 2 3 64

Products for CYB561 Gene

Sources for CYB561 Gene

Content
Loading form....