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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYB561 Gene

protein-coding GIFtS: 54
GCID: GC17M061509

cytochrome b-561

Explore 2 diseases affiliated with
CYB561 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome B-561¹ ² ³
FRRS2¹ ²
Cytochrome B561²
Ferric-Chelate Reductase 2²

External Ids:	HGNC: 2571¹	Entrez Gene: 1534²	Ensembl: ENSG00000008283⁷	OMIM: 600019⁵	UniProtKB: P49447³

Export aliases for CYB561 gene to outside databases

Previous GC identifers: GC17M061161 GC17M063936 GC17M061850 GC17M061983 GC17M058863 GC17M056878

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CY561_HUMAN, P49447

Function: Secretory vesicle-specific electron transport protein

Gene Wiki entry for CYB561

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYB561 gene promoter:
Bach1 Max1 GR Nkx2-5 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYB561 promoter sequence

Search SABiosciences Chromatin IP Primers for CYB561

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYB561

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23.3

CYB561 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYB561 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M061509: view genomic region (about GC identifiers)

Start:	61,509,665 bp from pter	End:	61,523,739 bp from pter
Size:	14,075 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CY561_HUMAN, P49447 (See protein sequence)

Recommended Name: Cytochrome b561

Size: 251 amino acids; 27559 Da

Cofactor: Binds 2 heme groups non-covalently (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: B2RE96 D3DU11 Q5BJG9 Q9BU05 Q9BWR9

Explore the universe of human proteins at neXtProt for CYB561: NX_P49447

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49447

CYB561 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001017916.1 NP_001017917.1 NP_001906.3

ENSEMBL proteins:

ENSP00000376701 ENSP00000354028 ENSP00000463162 ENSP00000464470 ENSP00000462325

ENSP00000400350 ENSP00000464012 ENSP00000464520 ENSP00000442773 ENSP00000462545

ENSP00000464215 ENSP00000462543 ENSP00000464193 ENSP00000463680 ENSP00000376702

Human Recombinant Protein Products for CYB561:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
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	GenScript Custom Purified and Recombinant Proteins Services for CYB561
	Novus Biologicals CYB561 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYB561

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	--	--
GO:0016021	integral to membrane	NAS	7559396

CYB561 for ontologies About GeneDecksing

CYB561 Antibody Products:

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	Search ThermoFisher Antibodies for CYB561

Assay Products for CYB561:

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	GenScript Custom Assay Services for CYB561
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CYB561

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYB561 for domains About GeneDecksing

2 InterPro domains/families:

IPR004877 Cyt_b561_euk

IPR006593 Cyt_b561/ferric_Rdtase_TM

Graphical View of Domain Structure for InterPro Entry P49447

ProtoNet protein and cluster: P49447

1 Blocks protein family: IPB006593 Cytochrome b561 / ferric reductase transmembrane

UniProtKB/Swiss-Prot: CY561_HUMAN, P49447

Similarity: Contains 1 cytochrome b561 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CY561_HUMAN, P49447

Function: Secretory vesicle-specific electron transport protein

Genatlas biochemistry entry for CYB561:

cytochrome b561 (30kDaA), specific to catecholamine and neuropeptide secretory vesicles of neuroendocrine tissues

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000293	ferric-chelate reductase activity	ISS	14499595
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	--	--
GO:0022865	transmembrane electron transfer carrier	NAS	7559396
GO:0046872	metal ion binding	IEA	--

CYB561 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cyb561):

behavior/neurological

homeostasis/metabolism

other

skeleton

vision/eye

CYB561 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CYB561

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CYB561 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYB561
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CYB561 (see all 15):
		hsa-miR-30c hsa-miR-588 hsa-miR-2114 hsa-miR-186* hsa-miR-452* hsa-miR-30d hsa-miR-570 hsa-miR-182

		SwitchGear 3'UTR luciferase reporter plasmid: CYB561 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYB561 (see all 7) OriGene shRNA RFP: CYB561 OriGene siRNA: CYB561
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CYB561

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CYB561
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB561 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB561 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CYB561 (NM_001915)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYB561
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB561

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CYB561
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		Sirion Biotech Customized stable knockdown cell line services for CYB561 Sirion Biotech Customized inducible knockdown cell line services for CYB561 Sirion Biotech Customized stable overexpressing cell line services for CYB561 Sirion Biotech Customized inducible overexpressing cell line services for CYB561

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB561

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYB561

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for CYB561 (P49447³ ENSP00000354028⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CREB3	O43889³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006091	generation of precursor metabolites and energy	--	--
GO:0022900	electron transport chain	NAS	7559396

CYB561 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYB561 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYB561

1 HMDB Compound for CYB561 About this table

Compound	Synonyms	CAS #	PubMed Ids
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--

9 Novoseek chemical compound relationships for CYB561 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
peptidylglycine	66.5	2	15691328 (1), 7476021 (1)
ferricyanide	65	4	1849895 (3)
ascorbic acid	64.4	33	2246231 (8), 1849895 (6), 1962566 (2), 11300772 (1) (see all 13)
histidine	43.8	2	11300772 (1), 17905810 (1)
hydroxylamine	37.5	1	2398057 (1)
catecholamine	31.9	5	18180394 (1), 7980462 (1)
dopamine	30.4	8	9778036 (1), 9852206 (1), 1785690 (1), 7476021 (1) (see all 5)
norepinephrine	13.1	1	11532994 (1)
hydrogen	12.5	2	1849895 (1), 17905810 (1)

Search CenterWatch for drugs/clinical trials and news about CYB561 / CY561

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYB561 gene (4 alternative transcripts):

NM_001017918.1 NM_001017916.1 NM_001017917.1 NM_001915.3

Unigene Cluster for CYB561:

Cytochrome b-561

Hs.355264 [show with all ESTs]

Unigene Representative Sequence: AK095244

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000392975(uc002jar.3) ENST00000360793(uc002jap.3 uc002jaq.3 uc002jat.3 uc010wpf.2 uc010wpg.2)

ENST00000584031(uc002jas.3 uc010ddt.3) ENST00000582297 ENST00000581573

ENST00000448884 ENST00000585153 ENST00000582034 ENST00000542042 ENST00000580691

ENST00000581163 ENST00000582997 ENST00000582143 ENST00000584291 ENST00000577989

ENST00000577368 ENST00000578016 ENST00000578072

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CYB561 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYB561
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CYB561 (see all 15):
		hsa-miR-30c hsa-miR-588 hsa-miR-2114 hsa-miR-186* hsa-miR-452* hsa-miR-30d hsa-miR-570 hsa-miR-182

		SwitchGear 3'UTR luciferase reporter plasmid: CYB561 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYB561 (see all 7) OriGene shRNA RFP: CYB561 OriGene siRNA: CYB561
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYB561
		Sirion Biotech Custom design and validation of potent shRNA sequences against CYB561

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYB561 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYB561 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CYB561 (NM_001915)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYB561
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB561

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYB561 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYB561
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYB561

Additional cDNA sequence:

AK026598.1 AK095244.1 AK294403.1 AK294630.1 AK301541.1 AK303177.1 AK316606.1 BC000021.1

BC002976.1 BC091485.1 BT007096.1

24 DOTS entries:

DT.400224 DT.120919993 DT.100044729 DT.100044730 DT.87016270 DT.100685259 DT.100862436 DT.120920027

DT.87014982 DT.92441145 DT.100044731 DT.97862201 DT.92441146 DT.100799536 DT.95227198 DT.120919965

DT.120920009 DT.120920026 DT.95227192 DT.100672359 DT.120920029 DT.91803522 DT.92441140 DT.92441143

9 AceView cDNA sequences:

AK095244 CR624200 BC000021 NM_001915 BC002976 BT007096 AK026598 BX648452

U06715

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for CYB561 (see all 18) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^	11a	·	11b	·
SP1:																							-						-		-				-						-		-
SP2:													-		-		-		-		-		-						-		-				-						-		-
SP3:											-		-		-		-		-		-		-						-		-				-						-		-
SP4:													-		-		-		-		-		-						-		-				-						-		-
SP5:																	-		-		-		-						-		-										-		-

ExUns:	11c	^	12a	·	12b	·	12c	·	12d	·	12e	·	12f	·	12g	·	12h	·	12i	·	12j	·	12k	^	13
SP1:			-
SP2:			-
SP3:			-
SP4:			-		-		-		-		-		-		-		-		-		-		-
SP5:			-

ECgene alternative splicing isoforms for CYB561

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYB561 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGAAAACT

About this image

CYB561 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CYB561 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYB561

SOURCE GeneReport for Unigene cluster: Hs.355264

SABiosciences Custom PCR Arrays for CYB561

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYB561 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CYB561
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYB561
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYB561

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB561

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB561 gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cyb561^{1 , 5}	cytochrome b-561^{1, 5}	85.02(n)¹ 88.66(a)¹		11 (68.81 cM)⁵ 13056¹ NM_007805.4¹ NP_031831.2¹ 105933702⁵
chicken (Gallus gallus)	Aves	CYB561¹	cytochrome b-561	72.56(n) 67.87(a)		419952 XM_003642778.1 XP_003642826.1
African clawed frog (Xenopus laevis)	Amphibia	Xl.27548²	Xenopus laevis cytochrome B561 (xcyt) mRNA, complete more	71.47(n)		U16364.1
zebrafish (Danio rerio)	Actinopterygii	cyb561¹	cytochrome b-561	61.76(n) 60.92(a)		568765 NM_001128744.1 NP_001122216.1
fruit fly (Drosophila melanogaster)	Insecta	CG1275³	electron transporter	38(a)		62D4 --
worm (Caenorhabditis elegans)	Secernentea	F55H2.5³	Cytochrome B561	36(a)		III(9583191-9584501) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ACYB-2⁶ AT1G26100⁶ (see all 4)	cytochrome B561 domain-containing protein (see all 4)	32(a) 30(a) (see all 4)	many ↔ many many ↔ many (see all 4)	4(13053686-13055623) 1(9022542-9024081)
rice (Oryza sativa)	Liliopsida	Os10g0118800¹	hypothetical protein	53.27(n) 41.71(a)		4347995 NM_001070595.1 NP_001064060.1

ENSEMBL Gene Tree for CYB561 (if available)
TreeFam Gene Tree for CYB561 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYB561 gene

CYBRD1² CYBASC3²

2 SIMAP similar genes for CYB561 using alignment to 11 protein entries: CY561_HUMAN (see all proteins):

CYBASC3 CYBRD1

CYB561 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187314844^1,2		--	61509195(+)	`ACAAAC/GCGCAC`	3	--	ds500¹		0	--	--	--	--
rs149311583^1,2		--	61509224(+)	`TTTGCC/GAAAAA`	3	--	ds500¹		0	--	--	--	--
rs9906905^1,2	C,H	--	61509387(+)	`TCAGGC/TTCTTG`	3	--	ds500¹		5		NS EA WA	510
rs143614606^1,2		--	61509405(+)	`ACCATC/TCAGGC`	3	--	ds500¹		0	--	--	--	--
rs8072403^1,2	C,F	--	61509422(+)	`CTCAGG/ACTGAG`	3	--	ds500¹		1		WA	118
rs192218264^1,2		--	61509598(+)	`CGTCAC/TGTGTC`	3	--	ds500¹		0	--	--	--	--
rs11541386^1,2	C	--	61509721(+)	`TTCACA/GGAAGA`	3	--	ut3¹ ese³		2		NA	4
rs147972081^1,2		--	61509838(+)	`ACTTTC/TGTTGC`	3	--	ut3¹		0	--	--	--	--
rs142389857^1,2		--	61509922(+)	`AAGGCA/GGAGTT`	3	--	ut3¹		0	--	--	--	--
rs77530319^1,2	C	--	61510137(+)	`GAAATG/TACACT`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CYB561 (61509665 - 61523739 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYB561: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CYB561 for disorders           About GeneDecksing

OMIM gene information: 600019    OMIM disorders: --

2 diseases for CYB561:    About MalaCards

astrocytoma neuroblastoma

Human Genome Epidemiology (HuGE) Navigator: CYB561 (2 documents)

Export disorders for CYB561 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CYB561 gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with CYB561)

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Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane. (PubMed id 7559396)^{1, 2, 9} Srivastava M. (1995)
Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information. (PubMed id 7980462)^{1, 2, 9} Srivastava M.... Fleming P.J. (1994)
The human cytochrome b561 gene (CYB561) is located at 17q11-qter. (PubMed id 7959749)^{1, 3, 9} McBride O.W....Srivastava M. (1994)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. (PubMed id 18180394)^{1, 9} Fung M.M....O'Connor D.T. (2008)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Nucleotide variations in mitochondrial DNA and supra- physiological ROS levels in cytogenetically normal cases of premature ovarian i nsufficiency. (PubMed id 20680310)¹ Kumar M....Dada R. (2010)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1534	HGNC: 2571	AceView: CYB561	Ensembl:ENSG00000008283	euGenes: HUgn1534
ECgene: CYB561	H-InvDB: CYB561

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CYB561	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYB561	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CYB561 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYB561 gene:
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GeneCards and IP:
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cytochrome b-561

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cytochrome b-561

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