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CYB561 Gene

protein-coding   GIFtS: 55
GCID: GC17M061509

Cytochrome B561

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome B5611 2     Member A11
Ferric-Chelate Reductase 21 2     CYB561A12
Cytochrome B-5612 3     FRRS22
Cytochrome B561 Family1     Cytochrome B561 Family, Member A12

External Ids:    HGNC: 25711   Entrez Gene: 15342   Ensembl: ENSG000000082837   OMIM: 6000195   UniProtKB: P494473   

Export aliases for CYB561 gene to outside databases

Previous GC identifers: GC17M061161 GC17M063936 GC17M061850 GC17M061983 GC17M058863 GC17M056878


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CYB561 Gene:
CYB561 (cytochrome b561) is a protein-coding gene. Diseases associated with CYB561 include astrocytoma, and neuroblastoma. GO annotations related to this gene include transmembrane electron transfer carrier and ferric-chelate reductase activity. An important paralog of this gene is CYBRD1.

UniProtKB/Swiss-Prot: CY561_HUMAN, P49447
Function: Secretory vesicle-specific electron transport protein

Gene Wiki entry for CYB561 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYB561 gene promoter:
         Bach1   Max1   GR   Nkx2-5   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYB561 promoter sequence
   Search Chromatin IP Primers for CYB561

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYB561


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23.3

CYB561 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYB561 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M061509:  view genomic region     (about GC identifiers)

Start:
61,509,665 bp from pter      End:
61,523,739 bp from pter
Size:
14,075 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CY561_HUMAN, P49447 (See protein sequence)
Recommended Name: Cytochrome b561  
Size: 251 amino acids; 27559 Da
Cofactor: Binds 2 heme groups non-covalently (By similarity)
Secondary accessions: B2RE96 D3DU11 Q5BJG9 Q9BU05 Q9BWR9

Explore the universe of human proteins at neXtProt for CYB561: NX_P49447

Explore proteomics data for CYB561 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYB561 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001017916.1  NP_001017917.1  NP_001906.3  

    ENSEMBL proteins: 
     ENSP00000376701   ENSP00000354028   ENSP00000463162   ENSP00000464470   ENSP00000462325  
     ENSP00000400350   ENSP00000464012   ENSP00000464520   ENSP00000442773   ENSP00000462545  
     ENSP00000464215   ENSP00000462543   ENSP00000464193   ENSP00000463680   ENSP00000376702  

    CYB561 Human Recombinant Protein Products:

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    Novus Biologicals CYB561 Protein
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    Cloud-Clone Corp. Proteins for CYB561

    CYB561 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for CYB561

    CYB561 Assay Products:

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    Cloud-Clone Corp. ELISAs for CYB561
    Cloud-Clone Corp. CLIAs for CYB561


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYB: Cytochrome b genes

    3 InterPro protein domains:
     IPR028837 Cytochrome_b561
     IPR004877 Cyt_b561_euk
     IPR006593 Cyt_b561/ferric_Rdtase_TM

    Graphical View of Domain Structure for InterPro Entry P49447

    ProtoNet protein and cluster: P49447

    1 Blocks protein domain: IPB006593 Cytochrome b561 / ferric reductase transmembrane

    UniProtKB/Swiss-Prot: CY561_HUMAN, P49447
    Similarity: Contains 1 cytochrome b561 domain


    CYB561 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CY561_HUMAN, P49447
    Function: Secretory vesicle-specific electron transport protein

         Genatlas biochemistry entry for CYB561:
    cytochrome b561 (30kDaA), specific to catecholamine and neuropeptide secretory vesicles of neuroendocrine tissues

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000293ferric-chelate reductase activity ISS14499595
    GO:0022865transmembrane electron transfer carrier NAS7559396
    GO:0046872metal ion binding IEA--
         
    CYB561 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cyb561):
     behavior/neurological  homeostasis/metabolism  other  skeleton  vision/eye 

    CYB561 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYB561
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYB561
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYB561

    miRNA
    Products:
        
    miRTarBase miRNAs that target CYB561:
    hsa-mir-18a-3p (MIRT040786), hsa-mir-335-5p (MIRT017264)

    Block miRNA regulation of human, mouse, rat CYB561 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYB561 (see all 15):
    hsa-miR-30c hsa-miR-588 hsa-miR-2114 hsa-miR-186* hsa-miR-452* hsa-miR-30d hsa-miR-570 hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidCYB561 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CYB561

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    GenScript: all cDNA clones in your preferred vector (see all 3): CYB561 (NM_001915)
    Sino Biological Human cDNA Clone for CYB561
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYB561
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB561

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CYB561 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB561


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CY561_HUMAN, P49447: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane NAS7559396

    CYB561 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYB561
    Interactions:

        Search GeneGlobe Interaction Network for CYB561

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for CYB561 (P494473 ENSP000003540284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    NAPAENSP000002633544STRING: ENSP00000263354
    NAPBENSP000003662254STRING: ENSP00000366225
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022900electron transport chain NAS7559396
    GO:0055085transmembrane transport NAS7559396

    CYB561 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYB561 (CY561)

    1 HMDB Compound for CYB561    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    9 Novoseek inferred chemical compound relationships for CYB561 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peptidylglycine 66.5 2 15691328 (1), 7476021 (1)
    ferricyanide 65 4 1849895 (3)
    ascorbic acid 64.4 33 2246231 (8), 1849895 (6), 1962566 (2), 11300772 (1) (see all 13)
    histidine 43.8 2 11300772 (1), 17905810 (1)
    hydroxylamine 37.5 1 2398057 (1)
    catecholamine 31.9 5 18180394 (1), 7980462 (1)
    dopamine 30.4 8 9778036 (1), 9852206 (1), 1785690 (1), 7476021 (1) (see all 5)
    norepinephrine 13.1 1 11532994 (1)
    hydrogen 12.5 2 1849895 (1), 17905810 (1)



    CYB561 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYB561 gene (4 alternative transcripts): 
    NM_001017918.1  NM_001017916.1  NM_001017917.1  NM_001915.3  

    Unigene Cluster for CYB561:

    Cytochrome b561
    Hs.355264  [show with all ESTs]
    Unigene Representative Sequence: AK095244
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000392975(uc002jar.3) ENST00000360793(uc002jap.3 uc002jaq.3 uc002jat.3 uc010wpf.2 uc010wpg.2)
    ENST00000584031(uc002jas.3 uc010ddt.3) ENST00000582297 ENST00000581573
    ENST00000448884 ENST00000585153 ENST00000582034 ENST00000542042 ENST00000580691
    ENST00000581163 ENST00000582997 ENST00000582143 ENST00000584291 ENST00000577989
    ENST00000577368 ENST00000578016 ENST00000578072

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CYB561 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYB561 (see all 15):
    hsa-miR-30c hsa-miR-588 hsa-miR-2114 hsa-miR-186* hsa-miR-452* hsa-miR-30d hsa-miR-570 hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidCYB561 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CYB561
    Predesigned siRNA for gene silencing in human, mouse, rat CYB561
    Clone
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    OriGene clones in human, mouse for CYB561 (see all 16)
    OriGene ORF clones in mouse, rat for CYB561
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CYB561 (NM_001915)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYB561
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYB561
    Primer
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    OriGene qPCR primer pairs and template standards for CYB561
    OriGene qSTAR qPCR primer pairs in human, mouse for CYB561
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYB561
      QuantiTect SYBR Green Assays in human, mouse, rat CYB561
      QuantiFast Probe-based Assays in human, mouse, rat CYB561

    Additional mRNA sequence: 

    AK026598.1 AK095244.1 AK294403.1 AK294630.1 AK301541.1 AK303177.1 AK316606.1 BC000021.1 
    BC002976.1 BC091485.1 BT007096.1 

    24 DOTS entries:

    DT.400224  DT.120919993  DT.100044729  DT.100044730  DT.87016270  DT.100685259  DT.100862436  DT.120920027 
    DT.87014982  DT.92441145  DT.100044731  DT.97862201  DT.92441146  DT.100799536  DT.95227198  DT.120919965 
    DT.120920009  DT.120920026  DT.95227192  DT.100672359  DT.120920029  DT.91803522  DT.92441140  DT.92441143 

    9 AceView cDNA sequences:

    CR624200 AK095244 BC000021 BT007096 BC002976 NM_001915 AK026598 BX648452 
    U06715 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYB561 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ·
    SP1:                                                                    -                 -     -           -                 -     -                           
    SP2:                                      -     -     -     -     -     -                 -     -           -                 -     -                           
    SP3:                                -     -     -     -     -     -     -                 -     -           -                 -     -                           
    SP4:                                      -     -     -     -     -     -                 -     -           -                 -     -                           
    SP5:                                                  -     -     -     -                 -     -                             -     -                           

    ExUns: 11c ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k ^ 13
    SP1:        -                                                                     
    SP2:        -                                                                     
    SP3:        -                                                                     
    SP4:        -     -     -     -     -     -     -     -     -     -     -         
    SP5:        -                                                                     


    ECgene alternative splicing isoforms for CYB561

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYB561 expression in normal human tissues (normalized intensities)      CYB561 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGAAAACT
    CYB561 Expression
    About this image


    CYB561 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
             Peripheral blood-derived hematopoietic stem cells
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Ovary (Reproductive System)
    CYB561 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYB561 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.355264
        Custom PCR Arrays for CYB561
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYB561

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYB561 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyb5611 , 5 cytochrome b-5611, 5 86.36(n)1
    90.3(a)1
      11 (68.81 cM)5
    130561  NM_007805.41  NP_031831.21 
     1059337025 
    chicken
    (Gallus gallus)
    Aves CYB5611 cytochrome b-561 73.65(n)
    70.51(a)
      419952  XM_418073.4  XP_418073.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.275482 Xenopus laevis cytochrome B561 (xcyt) mRNA, complete more 71.47(n)    U16364.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyb5611 cytochrome b-561 61.58(n)
    60.59(a)
      568765  NM_001128744.1  NP_001122216.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG12753 electron transporter 38(a)   62D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea F55H2.53
    CELE_F55H2.51
    Cytochrome B5613
    CELE_F55H2.51
    36(a)3
    46.38(n)1
    40.57(a)1
      III(9583191-9584501)3
    1863431  NM_066694.11  NP_499095.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACYB-21 ACYB-2 46.58(n)
    37.44(a)
      828662  NM_118689.3  NP_567723.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g05042001 Os10g0504200 48.92(n)
    40.86(a)
      4349055  NM_001071537.1  NP_001065002.1 


    ENSEMBL Gene Tree for CYB561 (if available)
    TreeFam Gene Tree for CYB561 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYB561 gene
    CYBRD12  CYB561A32  
    2 SIMAP similar genes for CYB561 using alignment to 11 protein entries:     CY561_HUMAN (see all proteins):
    CYB561A3    CYBRD1

    CYB561 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYB561 (see all 343)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873148441,2
    --61509195(+) ACAAAC/GCGCAC 3 -- ds50010--------
    rs1493115831,2
    --61509224(+) TTTGCC/GAAAAA 3 -- ds50010--------
    rs99069051,2
    C,H--61509387(+) TCAGGC/TTCTTG 3 -- ds50015Minor allele frequency- T:0.00NS EA WA 510
    rs1436146061,2
    --61509405(+) ACCATC/TCAGGC 3 -- ds50010--------
    rs80724031,2
    C,F--61509422(+) CTCAGG/ACTGAG 3 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1922182641,2
    --61509598(+) CGTCAC/TGTGTC 3 -- ds50010--------
    rs115413861,2
    C--61509721(+) TTCACA/GGAAGA 3 -- ut31 ese32Minor allele frequency- G:0.00NA 4
    rs1479720811,2
    C--61509838(+) ACTTTC/TGTTGC 3 -- ut310--------
    rs1423898571,2
    --61509922(+) AAGGCA/GGAGTT 3 -- ut310--------
    rs775303191,2
    C--61510137(+) GAAATG/TACACT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CYB561 (61509665 - 61523739 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CYB561:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908682CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYB561
    DNA2.0 Custom Variant and Variant Library Synthesis for CYB561

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600019    OMIM disorders: --

    5 diseases for CYB561:    About MalaCards
    astrocytoma    neuroblastoma    cervicitis    cerebritis
    prostatitis


    CYB561 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CYB561
    Human Genome Epidemiology (HuGE) Navigator: CYB561 (2 documents)

    Export disorders for CYB561 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYB561 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with CYB561)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane. (PubMed id 7559396)1, 2, 9 Srivastava M. (J. Biol. Chem. 1995)
    2. Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information. (PubMed id 7980462)1, 2, 9 Srivastava M.... Fleming P.J. (Biochem. J. 1994)
    3. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. (PubMed id 18180394)1, 4, 9 Fung M.M....O'Connor D.T. (Circulation 2008)
    4. The human cytochrome b561 gene (CYB561) is located at 17q11-qter. (PubMed id 7959749)1, 3, 9 McBride O.W....Srivastava M. (Genomics 1994)
    5. Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PubMed id 23249217)1, 3 Asard H....BAcrczi A. (amp 2013)
    6. Nucleotide variations in mitochondrial DNA and supra-physiological ROS levels in cytogenetically normal cases of premature ovarian insufficiency. (PubMed id 20680310)1, 4 Kumar M....Dada R. (Arch. Gynecol. Obstet. 2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Human heart rate: heritability of resting and stress values in twin pairs, and influence of genetic variation in the adrenergic pathway at a microribonucleic acid microRNA motif in the 3'-UTR of cytochrome b561. (PubMed id 24140660)1 Zhang K....O'Connor D.T. (J. Am. Coll. Cardiol. 2014)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1534 HGNC: 2571 AceView: CYB561 Ensembl:ENSG00000008283 euGenes: HUgn1534
    ECgene: CYB561 H-InvDB: CYB561

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYB561 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYB561 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYB561 gene:
    Search GeneIP for patents involving CYB561

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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