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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXorf67 Gene

protein-coding   GIFtS: 33
GCID: GC0XP051149

chromosome X open reading frame 67
 Explore 2 diseases affiliated with
CXorf67 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CXorf67    

Aliases
for CXorf67 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome X Open Reading Frame 671 2

External Ids:    HGNC: 337381   Entrez Gene: 3406022   Ensembl: ENSG000001876907   UniProtKB: Q86X513   

Export aliases for CXorf67 gene to outside databases

Previous GC identifers: GC0XP051167 GC0XP048591


Summaries
for CXorf67 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for CXorf67 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011638.13  NC_018934.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXorf67 gene promoter:
         GCNF   NF-YC   FOXL1   Gfi-1   NF-YB   HEN1   GCNF-1   SEF-1 (1)   GCNF-2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CXorf67

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf67


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

CXorf67 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf67 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP051149:  view genomic region     (about GC identifiers)

Start:
 51,149,767 bp from pter      End:
 51,151,690 bp from pter
Size:
 1,924 bases      Orientation:
 plus strand

Proteins
for CXorf67 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CX067_HUMAN, Q86X51 (See protein sequence)
Recommended Name: Uncharacterized protein CXorf67  
Size: 503 amino acids; 51894 Da

Explore the universe of human proteins at neXtProt for CXorf67: NX_Q86X51

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86X51

    • CXorf67 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).


    ENSEMBL proteins: 
     ENSP00000342680  

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    Protein Domains /
    Families
    for CXorf67 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q86X51


    Function
    for CXorf67 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for CXorf67 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXorf67

    Drugs & Compounds
    for CXorf67 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXorf67
    Search CenterWatch for drugs/clinical trials and news about CXorf67 / CX067 

    Transcripts
    for CXorf67 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CXorf67 gene: 
    NM_203407.1  

    Unigene Cluster for CXorf67:

    Chromosome X open reading frame 67
    Hs.97053  [show with all ESTs]
    Unigene Representative Sequence: BC046248
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000342995

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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    BC046248.1 XR_109761.1 XR_113306.1 XR_171129.1 XR_172403.1 

    1 DOTS entry:

    DT.40118904 

    8 AceView cDNA sequences:

    AA368976 BC046248 NM_203407 AW664691 AA368977 CB993573 CB991964 BQ216600 

    GeneLoc Exon Structure


    Expression
    for CXorf67 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXorf67 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTCCACCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CXorf67 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    BoneThoracic RibBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System

    See CXorf67 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXorf67

    SOURCE GeneReport for Unigene cluster: Hs.97053
        SABiosciences Custom PCR Arrays for CXorf67
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    In Situ
    Assay Products:     
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    Orthologs
    for CXorf67 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for CXorf67 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia AU0227515 expressed sequence AU022751   --   X (2.70 cM) 6081219 


    ENSEMBL Gene Tree for CXorf67 (if available)
    TreeFam Gene Tree for CXorf67 (if available) 

    Paralogs
    for CXorf67 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXorf67 gene

    CXorf67 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CXorf67
    PGOHUM00000235122


    Genomic Variants
    for CXorf67 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/58 NCBI SNPs in CXorf67 are shown (see all 58)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs128560541,2
    		H--48591787(+) CACTCC/TTAAGC 1 -- nc-transcript-variantese34Minor allele frequency- T:0.00NS EA 406
    rs734960191,2
    		C--48591966(+) GAATCT/AGCGCC 1 -- nc-transcript-variant1Minor allele frequency- A:0.50WA 2
    rs18757551,2
    		H--48592589(+) CCTTAG/AGTATG 1 -- nc-transcript-variantese39Minor allele frequency- A:0.00NA EA NS 628
    rs1886762691,2
    		--51147777(+) TATTGC/TACTCA 1 -- us2k10--------
    rs1499376621,2
    		--51147832(+) TATTTC/GTTTCC 1 -- us2k10--------
    rs1929973201,2
    		--51147969(+) CCCATC/TCTGCA 1 -- us2k10--------
    rs356382121,2
    		C,--51148089(+) TCCGAT/ATTTAT 1 -- us2k15Minor allele frequency- A:0.08NA EA 364
    rs1836285661,2
    		--51148468(+) TAAATA/TAATTA 1 -- us2k10--------
    rs1490822221,2
    		--51149395(+) TGACCA/GGGTGC 1 -- us2k10--------
    rs1880295761,2
    		--51149498(+) ACTCAA/CATCGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CXorf67 (51149767 - 51151690 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CXorf67: --

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    Disorders / Diseases
    for CXorf67 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CXorf67 for disorders           About GeneDecksing

    2 diseases for CXorf67:    About MalaCards
    prostate cancer    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: CXorf67 (1 document)

    Export disorders for CXorf67 gene to outside databases

    Publications
    for CXorf67 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXorf67 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CXorf67)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    2. Prostate cancer risk-associated variants reported fro m genome-wide association studies: meta-analysis and their contribution to gene tic Variation. (PubMed id 20564319)1 Kim S.T....Sun J. (2010)
    3. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (PubMed id 18264098)1 Gudmundsson J.... Stefansson K. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for CXorf67 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CXorf67 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340602 HGNC: 33738 AceView: LOC340602 Ensembl:ENSG00000187690 euGenes: HUgn340602
    ECgene: CXorf67 H-InvDB: CXorf67

    Other Databases showing CXorf67 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXorf67 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for CXorf67 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CXorf67 gene:
    Search GeneIP for patents involving CXorf67

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf67
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CXorf67
     Browse SwitchGear Promoter luciferase reporter plasmids for CXorf67
     Search ThermoFisher Antibodies for CXorf67
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXorf67
           
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    VWF
    (GIFTS: 73)
    von Willebrand factor
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