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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXorf67 Gene

protein-coding   GIFtS: 37
GCID: GC0XP051149

Chromosome X Open Reading Frame 67

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome X Open Reading Frame 671 2

External Ids:    HGNC: 337381   Entrez Gene: 3406022   Ensembl: ENSG000001876907   UniProtKB: Q86X513   

Export aliases for CXorf67 gene to outside databases

Previous GC identifers: GC0XP051167 GC0XP048591


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CXorf67 Gene: 
CXorf67 (chromosome X open reading frame 67) is a protein-coding gene. Diseases associated with CXorf67 include prostate cancer, and prostatitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011638.13  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXorf67 gene promoter:
         GCNF   NF-YC   FOXL1   Gfi-1   NF-YB   HEN1   GCNF-1   SEF-1 (1)   GCNF-2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CXorf67

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf67


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

CXorf67 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf67 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP051149:  view genomic region     (about GC identifiers)

Start:
51,149,767 bp from pter      End:
51,151,690 bp from pter
Size:
1,924 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CX067_HUMAN, Q86X51 (See protein sequence)
Recommended Name: Uncharacterized protein CXorf67  
Size: 503 amino acids; 51894 Da

Explore the universe of human proteins at neXtProt for CXorf67: NX_Q86X51

Explore proteomics data for CXorf67 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86X51

  • CXorf67 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXorf67 Protein Expression

    ENSEMBL proteins: 
     ENSP00000342680  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q86X51


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXorf67

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXorf67 (CX067)

    Search CenterWatch for drugs/clinical trials and news about CXorf67 / CX067

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CXorf67 gene: 
    NM_203407.1  

    Unigene Cluster for CXorf67:

    Chromosome X open reading frame 67
    Hs.97053  [show with all ESTs]
    Unigene Representative Sequence: BC046248
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000342995
    miRNA
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    Additional mRNA sequence: 

    BC046248.1 XR_109761.1 XR_113306.1 XR_171129.1 XR_172403.1 

    1 DOTS entry:

    DT.40118904 

    8 AceView cDNA sequences:

    AA368976 BC046248 NM_203407 AW664691 CB993573 AA368977 CB991964 BQ216600 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXorf67 expression in normal human tissues (normalized intensities)      CXorf67 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCCACCAC
    CXorf67 Expression
    About this image


    CXorf67 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Secondary Oocyte Antral Follicle
             Secondary follicles
             oocyte   
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   
     
     Bone (Muscoskeletal System)
             Thoracic Rib
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See CXorf67 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXorf67

    SOURCE GeneReport for Unigene cluster: Hs.97053
        SABiosciences Custom PCR Arrays for CXorf67
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf67

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CXorf67 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia AU0227515 expressed sequence AU022751   --   X (2.70 cM) 6081219 


    ENSEMBL Gene Tree for CXorf67 (if available)
    TreeFam Gene Tree for CXorf67 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXorf67 gene

    CXorf67 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CXorf67
    PGOHUM00000235122


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/89 SNPs in CXorf67 are shown (see all 89)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886762691,2
    --51159984(+) TATTGC/TACTCA 1 -- us2k10--------
    rs1499376621,2
    --51160039(+) TATTTC/GTTTCC 1 -- us2k10--------
    rs1929973201,2
    --51160176(+) CCCATC/TCTGCA 1 -- us2k10--------
    rs356382121,2
    C,F--51160296(+) TCCGAT/ATTTAT 1 -- us2k15Minor allele frequency- A:0.08NA EA 364
    rs1836285661,2
    --51160675(+) TAAATA/TAATTA 1 -- us2k10--------
    rs1490822221,2
    --51161602(+) TGACCA/GGGTGC 1 -- us2k10--------
    rs1880295761,2
    --51161705(+) ACTCAA/CATCGT 1 -- us2k10--------
    rs1462179431,2
    --51161781(+) AACACA/GTGTCT 1 -- us2k10--------
    rs2005927021,2
    --51161820(+) CACAC-/TACTGA 1 -- us2k10--------
    rs1389272811,2
    --51161974(+) GTCGAA/GGACTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CXorf67 (51149767 - 51151690 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CXorf67: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CXorf67
    DNA2.0 Custom Variant and Variant Library Synthesis for CXorf67

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CXorf67:    About MalaCards
    prostate cancer    prostatitis


    CXorf67 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CXorf67
    Human Genome Epidemiology (HuGE) Navigator: CXorf67 (1 document)

    Export disorders for CXorf67 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXorf67 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CXorf67)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prostate cancer risk-associated variants reported fro m genome-wide association studies: meta-analysis and their contribution to gene tic Variation. (PubMed id 20564319)1, 4 Kim S.T....Sun J. (2010)
    2. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (PubMed id 18264098)1, 4 Gudmundsson J.... Stefansson K. (2008)
    3. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    4. Identification of seven new prostate cancer susceptib ility loci through a genome-wide association study. (PubMed id 19767753)4 Eeles R.A....Cao G. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340602 HGNC: 33738 AceView: LOC340602 Ensembl:ENSG00000187690 euGenes: HUgn340602
    ECgene: CXorf67 H-InvDB: CXorf67

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXorf67 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXorf67 gene:
    Search GeneIP for patents involving CXorf67

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for CXorf67
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXorf67
    Customized:
     lentivirus for stable overexpression of CXorf67
     lentivirus expression plasmids for stable overexpression of CXorf67
     adenovirus for overexpression of CXorf67
     LSBio Antibodies in human, mouse, rat for CXorf67
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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