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CXorf66 Gene

protein-coding   GIFtS: 40
GCID: GC0XM139037

Chromosome X Open Reading Frame 66

  Search for CXorf66
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome X Open Reading Frame 661 2
RP11-35F15.22
Uncharacterized Protein CXorf662

External Ids:    HGNC: 337431   Entrez Gene: 3474872   Ensembl: ENSG000002039337   UniProtKB: Q5JRM23   

Export aliases for CXorf66 gene to outside databases

Previous GC identifers: GC0XM138866 GC0XM128305


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXorf66 Gene:
The protein encoded by this gene is predicted to be a type I membrane protein, however, its exact function is not
known. (provided by RefSeq, Sep 2009)

GeneCards Summary for CXorf66 Gene:
CXorf66 (chromosome X open reading frame 66) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CXorf66
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXorf66 promoter sequence
   Search Chromatin IP Primers for CXorf66

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXorf66


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27.1   Ensembl cytogenetic band:  Xq27.1   HGNC cytogenetic band: Xq27.1

CXorf66 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf66 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM139037:  view genomic region     (about GC identifiers)

Start:
139,037,884 bp from pter      End:
139,047,679 bp from pter
Size:
9,796 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CX066_HUMAN, Q5JRM2 (See protein sequence)
Recommended Name: Uncharacterized protein CXorf66 precursor  
Size: 361 amino acids; 39944 Da

Explore the universe of human proteins at neXtProt for CXorf66: NX_Q5JRM2

Explore proteomics data for CXorf66 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn24

  • See CXorf66 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001013421.1  
    ENSEMBL proteins: 
     ENSP00000359571  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5JRM2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CX066_HUMAN, Q5JRM2: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CXorf66           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CXorf66
    Interactions:

        Search GeneGlobe Interaction Network for CXorf66

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXorf66 (CX066)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CXorf66 gene: 
    NM_001013403.2  

    Unigene Cluster for CXorf66:

    Chromosome X open reading frame 66
    Hs.121384  [show with all ESTs]
    Unigene Representative Sequence: NM_001013403
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370540(uc004fbb.3)
    miRNA
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    hsa-miR-1290
    SwitchGear 3'UTR luciferase reporter plasmidCXorf66 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    BC137148.1 BC137149.1 

    1 DOTS entry:

    DT.306003 

    6 AceView cDNA sequences:

    AA913151 AA758774 BX100771 AA757386 BF979763 BF980066 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXorf66 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAAGCAA
    CXorf66 Expression
    About this image

    CXorf66 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXorf66 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121384
        Custom PCR Arrays for CXorf66
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf66

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CXorf66 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm70731 , 5 predicted gene 70731, 5 61.24(n)1
    37.97(a)1
      X (33.50 cM)5
    6317841  NM_001039240.31  NP_001034329.21 
     604360525 


    ENSEMBL Gene Tree for CXorf66 (if available)
    TreeFam Gene Tree for CXorf66 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXorf66 (see all 202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2000110691,2
    --138994742(+) TAGGA-/CTTCAG 1 -- ds50010--------
    rs1848874331,2
    --138994779(+) AGTCTA/GGGATA 1 -- ds50010--------
    rs1890019251,2
    --138994926(+) CTCCCA/GAGTAG 1 -- ds50010--------
    rs1809635071,2
    --138994945(+) ACAGAC/TGCCCA 1 -- ds50010--------
    rs1381973671,2
    C--138994986(+) AGTAGA/GGACGA 1 -- ds50010--------
    rs1870670481,2
    --138995078(+) TTACAA/GGTGTG 1 -- ds50010--------
    rs105876531,2
    C--138995169(+) AGGTC-/TAAG  
            
    TAAGA
    1 -- ds50010--------
    rs1911432321,2
    --138995260(+) TTTTTA/TAAATA 1 -- ut310--------
    rs1815457601,2
    C--138995359(+) TATAAA/GTTTGC 1 -- ut310--------
    rs1389476661,2
    C--138995428(+) GGTGAC/GTTGAT 2 L V mis11Minor allele frequency- G:0.00NA 4540

    HapMap Linkage Disequilibrium report for CXorf66 (139037884 - 139047679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXorf66:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672915CNV Deletion23128226

    Locus Specific Mutation Databases (LSDB): CXorf66

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXorf66
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CXorf66           About GenesLikeMe

    Genetic Association Database (GAD): CXorf66

    Export disorders for CXorf66 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXorf66 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CXorf66)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PubMed id 20889312)4 Wang K.S....Aragam N. (Schizophr. Res. 2010)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 347487 HGNC: 33743 AceView: LOC347487 Ensembl:ENSG00000203933 euGenes: HUgn347487
    ECgene: CXorf66 H-InvDB: CXorf66

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXorf66 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXorf66 gene:
    Search GeneIP for patents involving CXorf66

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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