Aliases for CXorf66 Gene
Aliases for CXorf66 Gene
External Ids for CXorf66 Gene
- HGNC: 33743
- Entrez Gene: 347487
- Ensembl: ENSG00000203933
- UniProtKB: Q5JRM2
Previous GeneCards Identifiers for CXorf66 Gene
- GC0XM138866
- GC0XM139037
- GC0XM128305
Summaries for CXorf66 Gene
-
The protein encoded by this gene is predicted to be a type I membrane protein, however, its exact function is not known. [provided by RefSeq, Sep 2009]
GeneCards Summary for CXorf66 Gene
CXorf66 (Chromosome X Open Reading Frame 66) is a Protein Coding gene.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf66 Gene
Genomics for CXorf66 Gene
Regulatory Elements for CXorf66 Gene
Enhancers for CXorf66 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG139847 | 0.4 | FANTOM5 | 8.8 | +117.8 | 117815 | 0.0 | NFIC | CXorf66 GC0XP139826 GC0XP139886 |
| GH0XG139972 | 0.5 | ENCODE | 0.4 | -8.3 | -8306 | 2.1 | GATA3 JUND HLF HNF4A | ATP11C CXorf66 LOC728660 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CXorf66 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CXorf66 Gene
- Chromosome:
- X
- Start:
- 139,955,725 bp from pter
- End:
- 139,965,520 bp from pter
- Size:
- 9,796 bases
- Orientation:
- Minus strand
Genomic View for CXorf66 Gene
Genes around CXorf66 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq27.1 by Ensembl
- Xq27.1 by Entrez Gene
- Xq27.1 by HGNC
CXorf66 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CXorf66 Gene
Proteins for CXorf66 Gene
-
Protein details for CXorf66 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5JRM2-CX066_HUMAN
- Recommended name:
- Uncharacterized protein CXorf66
- Protein Accession:
- Q5JRM2
Protein attributes for CXorf66 Gene
- Size:
- 361 amino acids
- Molecular mass:
- 39944 Da
- Quaternary structure:
- No Data Available
Protein Expression for CXorf66 Gene
Post-translational modifications for CXorf66 Gene
Other Protein References for CXorf66 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CXorf66
-
Abcam antibodies for CXorf66
- Invitrogen Antibodies for CXorf66
- antibodies-online Antibodies for CXorf66: See all 8
- GeneTex CXorf66 antibody for CXorf66
Protein Products
-
OriGene Purified Proteins for CXorf66
- Search Origene for MassSpec and Protein Over-expression Lysates for CXorf66
- Origene Custom Protein Services for CXorf66
- Novus Biologicals proteins for CXorf66
- Search GeneTex for Proteins for CXorf66
Assay Products
No data available for DME Specific Peptides for CXorf66 Gene
Domains & Families for CXorf66 Gene
Protein Domains for CXorf66 Gene
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CXorf66 Gene
Function for CXorf66 Gene
Phenotypes for CXorf66 Gene
- GenomeRNAi human phenotypes for CXorf66:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CXorf66
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CXorf66 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CXorf66 gene
- Search ViGene Biosciences for CXorf66
CRISPR Products
-
OriGene CRISPR knockouts for CXorf66
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXorf66
- GenScript: Design CRISPR guide RNA sequences for CXorf66
miRNA Products
- Search ViGene Biosciences for CXorf66
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CXorf66
- Browse OriGene Inhibitory RNA Products For CXorf66
-
ViGene Biosciences ready-to-package AAV shRNAs for CXorf66 gene
Clone Products
-
OriGene ORF clones in human for CXorf66
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CXorf66
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXorf66
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CXorf66
-
ViGene Biosciences adenoviral particle packaged cDNA for CXorf66 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CXorf66 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CXorf66 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CXorf66 Gene
Localization for CXorf66 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CXorf66 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 3 |
| plasma membrane | 1 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Transcripts for CXorf66 Gene
mRNA/cDNA for CXorf66 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (6) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CXorf66 Gene
- Chromosome X open reading frame 66:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CXorf66
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXorf66
- GenScript: Design CRISPR guide RNA sequences for CXorf66
miRNA Products
- Search ViGene Biosciences for CXorf66
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CXorf66
- Browse OriGene Inhibitory RNA Products For CXorf66
-
ViGene Biosciences ready-to-package AAV shRNAs for CXorf66 gene
Clone Products
-
OriGene ORF clones in human for CXorf66
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CXorf66
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXorf66
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CXorf66 Gene
mRNA differential expression in normal tissues according to GTEx for CXorf66 Gene
This gene is overexpressed in Testis (x52.3).
This gene is overexpressed in Heart (45.7) and Testis (23.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXorf66 Gene
NURSA nuclear receptor signaling pathways regulating expression of CXorf66 Gene:
CXorf66SOURCE GeneReport for Unigene cluster for CXorf66 Gene:
Hs.121384Primer Products
-
OriGene qPCR primer pairs for CXorf66
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf66 Gene
Orthologs for CXorf66 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CXHXorf66 34 |
|
||
| CXorf66 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CXHXorf66 34 |
|
||
| CXorf66 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gm7073 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC787011 34 |
|
||
| CXHXorf66 35 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | LOC688842 34 |
|
- Species where no ortholog for CXorf66 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CXorf66 Gene
No data available for Paralogs for CXorf66 Gene
Variants for CXorf66 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000204301 | -- | 139,958,382(+) | GCCAG(C/T)CCAGA | intron-variant | |
| rs1000216228 | -- | 139,967,314(+) | CCTTG(A/G)TTCTC | upstream-variant-2KB | |
| rs1000297835 | -- | 139,964,307(+) | ATATG(A/G)AAAAA | intron-variant | |
| rs1000400541 | -- | 139,957,029(+) | GGTGT(A/G)GTGGC | intron-variant | |
| rs1000478437 | -- | 139,966,641(+) | TTCCA(-/AATT)AATTA | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4302n106 | CNV | deletion | 24896259 |
| esv2672915 | CNV | deletion | 23128226 |
| esv3559395 | CNV | deletion | 23714750 |
| esv3577426 | CNV | gain | 25503493 |
Residual Variation Intolerance Score:
73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.46% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CXorf66 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CXorf66
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf66 Gene
Disorders for CXorf66 Gene
Relevant External Links for CXorf66
No disorders were found for CXorf66 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf66 Gene
Publications for CXorf66 Gene
- A novel transmembrane glycoprotein cancer biomarker present in the X chromosome. (PMID: 24709545) Delgado A.P. … Narayanan R. (Cancer Genomics Proteomics 2014) 2 3 64
- A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 46 64
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for CXorf66 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CXorf66
- Search Origene for MassSpec and Protein Over-expression Lysates for CXorf66
- Origene Custom Protein Services for CXorf66
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CXorf66
- Browse OriGene Inhibitory RNA Products For CXorf66
- OriGene qPCR primer pairs for CXorf66
- OriGene CRISPR knockouts for CXorf66
- OriGene ORF clones in human for CXorf66
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CXorf66
- GenScript: Next-day shipping cDNA ORF clone for CXorf66 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CXorf66
- GenScript Custom Assay Services for CXorf66
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- GenScript: Design CRISPR guide RNA sequences for CXorf66
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CXorf66
- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CXorf66
- Novus Biologicals proteins for CXorf66
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for CXorf66 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CXorf66 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CXorf66 gene
- Search ViGene Biosciences for CXorf66
- Horizon Cell Lines for CXorf66
- Cyagen custom Knockout/knockin (KOKI) mouse models for CXorf66
- VectorBuilder custom plasmid, inducible vectors for CXorf66
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXorf66
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CXorf66 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
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- (126) GTR
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer