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Aliases for CXorf65 Gene

Aliases for CXorf65 Gene

  • Chromosome X Open Reading Frame 65 2 3 5

External Ids for CXorf65 Gene

Previous GeneCards Identifiers for CXorf65 Gene

  • GC0XM070241
  • GC0XM070245
  • GC0XM070323
  • GC0XM064144

Summaries for CXorf65 Gene

GeneCards Summary for CXorf65 Gene

CXorf65 (Chromosome X Open Reading Frame 65) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf65 Gene

Genomics for CXorf65 Gene

Regulatory Elements for CXorf65 Gene

Enhancers for CXorf65 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF071100 1 ENCODE 14.7 -0.6 -564 13.4 HDGF PKNOX1 WRNIP1 ZFP64 ZNF121 ELK1 ZNF207 FOS REST TBX21 MED12 CXorf65 SNX12 IGBP1-AS1 IL2RG
GH0XF071095 1 ENCODE 13.2 +9.4 9370 5.0 CREB3L1 ZNF2 ETS1 ZNF121 GLIS2 GATA2 ZNF143 ZNF263 SP3 REST MED12 LOC392489 CXorf65 SNX12 RPS23P8 ENSG00000229601 P2RY4 IL2RG FOXO4
GH0XF071073 0.8 Ensembl ENCODE 12.4 +33.6 33572 0.8 HLF CEBPA STAT3 MAX CEBPB CEBPG EP300 IL2RG MED12 CXorf65 RNU1-56P NUTF2P7 SNX12 GC0XM071059
GH0XF071128 0.7 ENCODE 11.4 -22.0 -21999 1.9 ZNF263 CTCF ZNF654 ARID4B MAX TRIM22 REST RAD21 KLF16 ZNF143 CXorf65 IL2RG GC0XP071138 MED12
GH0XF070930 0.5 ENCODE 4.5 +176.0 175957 1.4 L3MBTL2 POLR2A SCRT2 CXorf65 SLC7A3 TEX11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXorf65 on UCSC Golden Path with GeneCards custom track

Promoters for CXorf65 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160895 -1528 201 NR2C2

Genomic Location for CXorf65 Gene

Chromosome:
X
Start:
71,103,889 bp from pter
End:
71,106,972 bp from pter
Size:
3,084 bases
Orientation:
Minus strand

Genomic View for CXorf65 Gene

Genes around CXorf65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf65 Gene

Proteins for CXorf65 Gene

  • Protein details for CXorf65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NEN9-CX065_HUMAN
    Recommended name:
    Uncharacterized protein CXorf65
    Protein Accession:
    A6NEN9

    Protein attributes for CXorf65 Gene

    Size:
    183 amino acids
    Molecular mass:
    21305 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXorf65 Gene

Post-translational modifications for CXorf65 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXorf65 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXorf65 Gene

Domains & Families for CXorf65 Gene

Protein Domains for CXorf65 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf65: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CXorf65 Gene

Function for CXorf65 Gene

Phenotypes for CXorf65 Gene

GenomeRNAi human phenotypes for CXorf65:
genes like me logo Genes that share phenotypes with CXorf65: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CXorf65 Gene

Localization for CXorf65 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf65 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CXorf65 Gene

Pathways & Interactions for CXorf65 Gene

SuperPathways for CXorf65 Gene

No Data Available

Interacting Proteins for CXorf65 Gene

Gene Ontology (GO) - Biological Process for CXorf65 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf65 Gene

Transcripts for CXorf65 Gene

mRNA/cDNA for CXorf65 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXorf65 Gene

Chromosome X open reading frame 65:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf65 Gene

No ASD Table

Relevant External Links for CXorf65 Gene

GeneLoc Exon Structure for
CXorf65
ECgene alternative splicing isoforms for
CXorf65

Expression for CXorf65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXorf65 Gene

mRNA differential expression in normal tissues according to GTEx for CXorf65 Gene

This gene is overexpressed in Testis (x19.3), Whole Blood (x14.5), and Spleen (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of CXorf65 Gene:

CXorf65

SOURCE GeneReport for Unigene cluster for CXorf65 Gene:

Hs.443936
genes like me logo Genes that share expression patterns with CXorf65: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CXorf65 Gene

Orthologs for CXorf65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXHXorf65 34
  • 99.64 (n)
CXorf65 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXHXorf65 34
  • 80.04 (n)
cow
(Bos Taurus)
Mammalia CXHXorf65 34
  • 79.84 (n)
CXorf65 35
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm614 34 16 35
  • 73.85 (n)
chicken
(Gallus gallus)
Aves C4HXorf65 34
  • 55.7 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC570432 34
  • 50.85 (n)
CXorf65 35
  • 30 (a)
OneToOne
Species where no ortholog for CXorf65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf65 Gene

ENSEMBL:
Gene Tree for CXorf65 (if available)
TreeFam:
Gene Tree for CXorf65 (if available)

Paralogs for CXorf65 Gene

No data available for Paralogs for CXorf65 Gene

Variants for CXorf65 Gene

Sequence variations from dbSNP and Humsavar for CXorf65 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111033617 Pathogenic 71,108,599(-) GGAAC(A/G)GTGAG upstream-variant-2KB, reference, missense
rs137852508 Pathogenic 71,108,336(-) TGCCC(C/T)GAATT upstream-variant-2KB, reference, stop-gained
rs137852509 Pathogenic 71,108,278(-) CTTTT(A/C)GGTGA upstream-variant-2KB, reference, stop-gained
rs137852510 Pathogenic 71,108,323(-) CACCC(A/T)GAAGA upstream-variant-2KB, reference, missense
rs112293690 -- 71,105,473(+) AGAAT(C/T)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf65 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv33082 CNV loss 17666407

Variation tolerance for CXorf65 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXorf65 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf65 Gene

Disorders for CXorf65 Gene

Relevant External Links for CXorf65

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXorf65

No disorders were found for CXorf65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf65 Gene

Publications for CXorf65 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  3. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3 64

Products for CXorf65 Gene

Sources for CXorf65 Gene

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