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Aliases for CXorf58 Gene

Aliases for CXorf58 Gene

  • Chromosome X Open Reading Frame 58 2 3 5

External Ids for CXorf58 Gene

Previous GeneCards Identifiers for CXorf58 Gene

  • GC0XP023835
  • GC0XP021670

Summaries for CXorf58 Gene

GeneCards Summary for CXorf58 Gene

CXorf58 (Chromosome X Open Reading Frame 58) is a Protein Coding gene. Diseases associated with CXorf58 include Retinitis Pigmentosa 11.

Additional gene information for CXorf58 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf58 Gene

Genomics for CXorf58 Gene

GeneHancer (GH) Regulatory Elements for CXorf58 Gene

Promoters and enhancers for CXorf58 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI023905 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.3 -254 3.3 ARID4B SIN3A ZNF2 YY1 E2F8 ZNF207 ZNF143 SP3 REST ZNF592 APOO CXorf58 KLHL15 ZFX EIF2S3 RPL9P7
GH0XI023821 Enhancer 0.7 ENCODE 12.7 -85.2 -85200 1.8 SOX13 PKNOX1 FOXA2 ZBTB21 ZNF449 ZNF384 FEZF1 ZNF121 GATA3 ZNF366 APOO CXorf58 PIR60902 GC0XP023786 GC0XP023785
GH0XI024014 Enhancer 0.6 ENCODE 12.5 +107.2 107202 0.8 ZNF146 ZNF687 NR2F1 BACH1 EBF1 ZNF664 ZFHX2 TARDBP IKZF1 ZNF600 APOO CXorf58 KLHL15 GC0XP023953
GH0XI023896 Enhancer 1.4 FANTOM5 Ensembl ENCODE 0.4 -8.0 -8007 6 PKNOX1 ARID4B TCF12 GLIS2 ARID2 ZNF143 ATF7 FOS RXRA JUNB SAT1 ACOT9 LOC105373148 ENSG00000202272 ZFX APOO EIF2S3 CXorf58 RPL9P7
GH0XI023883 Enhancer 1.4 FANTOM5 Ensembl ENCODE 0.3 -23.6 -23642 2.2 HDGF PKNOX1 FEZF1 ZNF2 ZNF121 ZNF766 KLF7 FOS TSHZ1 ZNF592 SAT1 ACOT9 LOC105373148 ENSG00000202272 APOO EIF2S3 ZFX CXorf58 RPL9P7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CXorf58 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXorf58 gene promoter:

Genomic Locations for CXorf58 Gene

Genomic Locations for CXorf58 Gene
chrX:23,907,801-23,939,507
(GRCh38/hg38)
Size:
31,707 bases
Orientation:
Plus strand
chrX:23,925,918-23,957,624
(GRCh37/hg19)

Genomic View for CXorf58 Gene

Genes around CXorf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf58 Gene

Proteins for CXorf58 Gene

  • Protein details for CXorf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LI9-CX058_HUMAN
    Recommended name:
    Putative uncharacterized protein CXorf58
    Protein Accession:
    Q96LI9

    Protein attributes for CXorf58 Gene

    Size:
    332 amino acids
    Molecular mass:
    38899 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXorf58 Gene

Post-translational modifications for CXorf58 Gene

No Post-translational modifications

Other Protein References for CXorf58 Gene

No data available for DME Specific Peptides for CXorf58 Gene

Domains & Families for CXorf58 Gene

Gene Families for CXorf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXorf58 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CXorf58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf58: view

No data available for UniProtKB/Swiss-Prot for CXorf58 Gene

Function for CXorf58 Gene

genes like me logo Genes that share phenotypes with CXorf58: view

Animal Model Products

miRNA for CXorf58 Gene

miRTarBase miRNAs that target CXorf58

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf58 Gene

Localization for CXorf58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf58 gene
Compartment Confidence
mitochondrion 2
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CXorf58 Gene

Pathways & Interactions for CXorf58 Gene

SuperPathways for CXorf58 Gene

No Data Available

Interacting Proteins for CXorf58 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368511%0d%0a9606.ENSP00000261386%0d%0a
Selected Interacting proteins: ENSP00000368511 Q96LI9-CX058_HUMAN for CXorf58 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CXorf58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf58 Gene

Drugs & Compounds for CXorf58 Gene

No Compound Related Data Available

Transcripts for CXorf58 Gene

mRNA/cDNA for CXorf58 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXorf58 Gene

Chromosome X open reading frame 58:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf58 Gene

No ASD Table

Relevant External Links for CXorf58 Gene

GeneLoc Exon Structure for
CXorf58
ECgene alternative splicing isoforms for
CXorf58

Expression for CXorf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf58 Gene

mRNA differential expression in normal tissues according to GTEx for CXorf58 Gene

This gene is overexpressed in Testis (x24.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXorf58 Gene



Protein tissue co-expression partners for CXorf58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CXorf58 Gene:

CXorf58

SOURCE GeneReport for Unigene cluster for CXorf58 Gene:

Hs.351265
genes like me logo Genes that share expression patterns with CXorf58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf58 Gene

Orthologs for CXorf58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf58 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CXHXorf58 33
  • 78.84 (n)
CXorf58 34
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685700 33
  • 76.89 (n)
cow
(Bos Taurus)
Mammalia CXHXorf58 33
  • 76.63 (n)
MGC165780 34
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia LOC102640868 33
  • 72.29 (n)
oppossum
(Monodelphis domestica)
Mammalia CXorf58 34
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXorf58 34
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXorf58 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxorf58 33
  • 58.37 (n)
zebrafish
(Danio rerio)
Actinopterygii CXorf58 34
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for CXorf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf58 Gene

ENSEMBL:
Gene Tree for CXorf58 (if available)
TreeFam:
Gene Tree for CXorf58 (if available)

Paralogs for CXorf58 Gene

No data available for Paralogs for CXorf58 Gene

Variants for CXorf58 Gene

Sequence variations from dbSNP and Humsavar for CXorf58 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000277974 -- 23,911,589(+) TT/T genic_upstream_transcript_variant, intron_variant
rs1000394046 -- 23,929,924(+) G/A intron_variant
rs1000451000 -- 23,912,465(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000880066 -- 23,908,802(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000929118 -- 23,912,125(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf58 Gene

Variant ID Type Subtype PubMed ID
nsv6836 CNV insertion 18451855

Variation tolerance for CXorf58 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf58 Gene

Disorders for CXorf58 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXorf58 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 11
  • rp11
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CXorf58

genes like me logo Genes that share disorders with CXorf58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXorf58 Gene

Publications for CXorf58 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CXorf58 Gene

Sources for CXorf58 Gene

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