Aliases for CXorf57 Gene
External Ids for CXorf57 Gene
- HGNC: 25486
- Entrez Gene: 55086
- Ensembl: ENSG00000147231
- UniProtKB: Q6NSI4
Previous GeneCards Identifiers for CXorf57 Gene
- GC0XP105741
- GC0XP105855
- GC0XP095482
Summaries for CXorf57 Gene
GeneCards Summary for CXorf57 Gene
CXorf57 (Chromosome X Open Reading Frame 57) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf57 Gene
Genomics for CXorf57 Gene
Regulatory Elements for CXorf57 Gene
Enhancers for CXorf57 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG106725 | 0.9 | ENCODE | 11.9 | +117.1 | 117095 | 6.5 | ELF3 TBP FOXA2 ARID4B DMAP1 ZBTB40 ZNF48 RAD21 RARA YY1 | RNF128 CXorf57 TBC1D8B GC0XM106712 |
| GH0XG106611 | 0.8 | ENCODE | 0.7 | +0.4 | 434 | 2.2 | PKNOX1 ARID4B ZNF121 ZNF366 ZSCAN5C SCRT2 CREM SP3 ZNF398 PRDM6 | CXorf57 MIR548AN |
| GH0XG106608 | 0.4 | ENCODE | 0.7 | -3.7 | -3665 | 0.2 | EP300 | CXorf57 GC0XP106598 |
| GH0XG106603 | 0.3 | FANTOM5 | 0.4 | -8.4 | -8432 | 0.1 | CLDN2 GC0XP106598 CXorf57 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CXorf57 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CXorf57 gene promoter:
Regulatory Element Products
Genomic Location for CXorf57 Gene
- Chromosome:
- X
- Start:
- 106,611,930 bp from pter
- End:
- 106,679,443 bp from pter
- Size:
- 67,514 bases
- Orientation:
- Plus strand
Genomic View for CXorf57 Gene
Genes around CXorf57 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq22.3 by Ensembl
- Xq22.3 by Entrez Gene
- Xq22.3 by HGNC
CXorf57 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CXorf57 Gene
Proteins for CXorf57 Gene
-
Protein details for CXorf57 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6NSI4-CX057_HUMAN
- Recommended name:
- Uncharacterized protein CXorf57
- Protein Accession:
- Q6NSI4
- H7BY89
- Q4G0L7
- Q5JQS1
- Q5JRF9
- Q6PHY5
- Q6PII9
- Q6PJU8
- Q9H7W5
- Q9NWA6
Protein attributes for CXorf57 Gene
- Size:
- 855 amino acids
- Molecular mass:
- 97554 Da
- Quaternary structure:
- No Data Available
Protein Expression for CXorf57 Gene
Post-translational modifications for CXorf57 Gene
Other Protein References for CXorf57 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CXorf57
-
Abcam antibodies for CXorf57
- Invitrogen Antibodies for CXorf57
- GeneTex CXorf57 antibody for CXorf57
- GeneTex Myo9b antibody for CXorf57
-
Santa Cruz Biotechnology (SCBT) Antibodies for CXorf57
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CXorf57
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- Novus Biologicals proteins for CXorf57
- Search GeneTex for Proteins for CXorf57
-
Abcam proteins for CXorf57
Assay Products
No data available for DME Specific Peptides for CXorf57 Gene
Domains & Families for CXorf57 Gene
Protein Domains for CXorf57 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CXorf57 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CXorf57 Gene
Function for CXorf57 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 22681889 |
| GO:0005515 | protein binding | IPI | 21516116 |
Phenotypes for CXorf57 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CXorf57
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CXorf57 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CXorf57 gene
- Search ViGene Biosciences for CXorf57
CRISPR Products
-
OriGene CRISPR knockouts for CXorf57
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXorf57
- GenScript: Design CRISPR guide RNA sequences for CXorf57
miRNA for CXorf57 Gene
- miRTarBase miRNAs that target CXorf57
miRNA Products
- Search ViGene Biosciences for CXorf57
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CXorf57
- Browse OriGene Inhibitory RNA Products For CXorf57
-
ViGene Biosciences ready-to-package AAV shRNAs for CXorf57 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CXorf57
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXorf57
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CXorf57
-
ViGene Biosciences adenoviral particle packaged cDNA for CXorf57 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CXorf57 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CXorf57 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf57 Gene
Localization for CXorf57 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| mitochondrion | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CXorf57 Gene
Pathways & Interactions for CXorf57 Gene
No Data Available
Interacting Proteins for CXorf57 Gene
Selected Interacting proteins:
Q6NSI4-CX057_HUMAN
ENSP00000361628
for CXorf57 Gene via
MINT
STRING
UniProtKB
IID
No data available for Pathways by source and SIGNOR curated interactions for CXorf57 Gene
Transcripts for CXorf57 Gene
mRNA/cDNA for CXorf57 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (69) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CXorf57 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CXorf57
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXorf57
- GenScript: Design CRISPR guide RNA sequences for CXorf57
miRNA Products
- Search ViGene Biosciences for CXorf57
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CXorf57
- Browse OriGene Inhibitory RNA Products For CXorf57
-
ViGene Biosciences ready-to-package AAV shRNAs for CXorf57 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CXorf57
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXorf57
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - |
Expression for CXorf57 Gene
mRNA differential expression in normal tissues according to GTEx for CXorf57 Gene
This gene is overexpressed in Brain - Hypothalamus (x8.1) and Pituitary (x6.6).
This gene is overexpressed in Stomach (17.3), Lung (12.7), Kidney (12.1), Fetal Brain (9.5), and Esophagus (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CXorf57 Gene
NURSA nuclear receptor signaling pathways regulating expression of CXorf57 Gene:
CXorf57SOURCE GeneReport for Unigene cluster for CXorf57 Gene:
Hs.274267Evidence on tissue expression from TISSUES for CXorf57 Gene
- Nervous system(4.5)
Primer Products
-
OriGene qPCR primer pairs for CXorf57
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf57 Gene
Orthologs for CXorf57 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CXHXorf57 34 |
|
||
| CXorf57 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CXHXorf57 34 |
|
||
| CXorf57 35 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | LOC680663 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CXHXorf57 34 |
|
||
| CXorf57 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | D330045A20Rik 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | C4HXORF57 34 |
|
||
| CXorf57 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100498514 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-26b3.2 34 |
|
||
| C5HXorf57 35 |
|
OneToOne |
- Species where no ortholog for CXorf57 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CXorf57 Gene
No data available for Paralogs for CXorf57 Gene
Variants for CXorf57 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000081101 | -- | 106,614,521(+) | TTGAA(C/T)GGCTT | intron-variant | |
| rs1000213973 | -- | 106,634,633(+) | CAAAC(C/T)TCACC | intron-variant | |
| rs1000321538 | -- | 106,631,195(+) | ACATA(A/G)TCAAT | intron-variant | |
| rs1000335469 | -- | 106,661,316(+) | TGTCA(C/T)ATATA | intron-variant | |
| rs1000366615 | -- | 106,662,077(+) | GGTGG(A/G)AGAGT | nc-transcript-variant, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2752312 | CNV | gain | 17911159 |
Residual Variation Intolerance Score:
8.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.84;
58.71% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CXorf57 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CXorf57
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf57 Gene
Disorders for CXorf57 Gene
Relevant External Links for CXorf57
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CXorf57
No disorders were found for CXorf57 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf57 Gene
Publications for CXorf57 Gene
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64
- Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. (PMID: 24550385) Abu-Odeh M. … Aqeilan R.I. (J. Biol. Chem. 2014) 3 64
Products for CXorf57 Gene
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- OriGene qPCR primer pairs for CXorf57
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- GenScript: Design CRISPR guide RNA sequences for CXorf57
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- Novus Biologicals Antibodies for CXorf57
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- Abcam antibodies for CXorf57
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- GeneTex Myo9b antibody for CXorf57
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- ViGene Biosciences adenoviral particle packaged cDNA for CXorf57 gene
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- Search ViGene Biosciences for CXorf57
- Santa Cruz Biotechnology (SCBT) Antibodies for CXorf57
- Search Santa Cruz Biotechnology (SCBT) for CXorf57 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CXorf57
- Horizon Cell Lines for CXorf57
- Cyagen custom Knockout/knockin (KOKI) mouse models for CXorf57
- VectorBuilder custom plasmid, inducible vectors for CXorf57
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CXorf57
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CXorf57 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer