CXorf57 Gene
protein-coding GIFtS: 41
GCID: GC0XP105855
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chromosome X open reading frame 57
| |
Aliases
for CXorf57 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome X Open Reading Frame 571 2 | | FLJ101781 | | FLJ141911 | | Uncharacterized Protein CXorf572 |
Export aliases for CXorf57 gene to outside databasesPrevious GC identifers: GC0XP105741 GC0XP095482 |
Summaries
for CXorf57 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CXorf57 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CXorf57 gene promoter:
USF1 SREBP-1c USF-1:USF-2 Evi-1 SREBP-1b S8 SREBP-1a FOXJ2 (long isoform) USF-1 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CXorf57
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf57 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.3 Ensembl cytogenetic band: Xq22.3 HGNC cytogenetic band: Xq22.3CXorf57 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP105855: view genomic region
(about GC identifiers)
Start:
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105,855,160 bp from pter |
End:
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105,922,673 bp from pter |
Size:
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67,514 bases |
Orientation:
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plus strand |
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Proteins
for CXorf57 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CX057_HUMAN, Q6NSI4 (See
protein sequence)Recommended Name: Uncharacterized protein CXorf57 Size: 855 amino acids; 97554 Da
Secondary accessions: H7BY89 Q4G0L7 Q5JQS1 Q5JRF9 Q6PHY5 Q6PII9 Q6PJU8 Q9H7W5 Q9NWA6Alternative splicing: 3 isoforms: Q6NSI4-1 Q6NSI4-2 Q6NSI4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CXorf57: NX_Q6NSI4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NSI4
CXorf57 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001171711.1 NP_060485.4
ENSEMBL proteins: ENSP00000361628 ENSP00000432238 ENSP00000405866 ENSP00000361623
Human Recombinant Protein Products:
CXorf57 Antibody Products:
Assay Products for CXorf57: |
Protein
Domains /
Families
for CXorf57 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CXorf57 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6NSI4ProtoNet protein and cluster: Q6NSI4 |
Function
for CXorf57 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXorf57 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXorf57 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CXorf57 (NM_018015) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXorf57 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXorf57 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf57 |
|
Pathways & Interactions
for CXorf57 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXorf57
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for CXorf57 (Q6NSI43 ENSP000003616284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CXorf57 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CXorf57
Search CenterWatch for drugs/clinical trials and news about CXorf57 / CX057
|
Transcripts
for CXorf57 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CXorf57 gene (2 alternative transcripts): NM_001184782.1 NM_018015.5 Unigene Cluster for CXorf57: Chromosome X open reading frame 57 Hs.274267 [show with all ESTs]Unigene Representative Sequence: NM_0180156 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372548(uc004emi.4) ENST00000461251(uc004emh.2) ENST00000421550
ENST00000478395 ENST00000497124 ENST00000372544(uc004emj.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXorf57 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXorf57 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CXorf57 (NM_018015) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXorf57 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXorf57 |
Additional cDNA sequence: AK024253.1 AK291730.1 BC011483.1 BC033709.1 BC047503.1 BC054032.2 BC070110.1 6 DOTS entries: DT.99956223 DT.210180 DT.99984868 DT.100679697 DT.100741642 DT.40112846 24/69 AceView cDNA sequences (see all 69): BM353473 BQ428524 AW090124 BP366777 BU952537 BC047503 BC011483 AI701290 CA840899 AK024253 BG055130 Z43441 BX115162 BQ776567 BE888074 BE896179 BG164440 BM904977 BU951098 BU520912 BI547851 AI805934 CD685756 BF110466
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CXorf57 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CXorf57
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Expression
for CXorf57 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CXorf57 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACATTTAAC
About this image
See CXorf57 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXorf57
SOURCE GeneReport for Unigene cluster: Hs.274267
SABiosciences Custom PCR Arrays for CXorf57
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXorf57
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXorf57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXorf57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXorf57 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf57 |
Orthologs
for CXorf57 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CXorf57 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for CXorf57 (if available)
TreeFam Gene Tree for CXorf57 (if available) |
Paralogs
for CXorf57 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CXorf57 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CXorf57 (105855160 - 105922673 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CXorf57
1 CNV: 8310
Locus Specific Mutation Databases (LSDB): CXorf57
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXorf57 |
|
Disorders
/ Diseases
for CXorf57 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CXorf57 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CXorf57 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with CXorf57) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for CXorf57 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CXorf57 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CXorf57 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CXorf57 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CXorf57 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CXorf57 gene:
Search GeneIP for patents involving CXorf57
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CXorf57 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CXorf57 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXorf57 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXorf57 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CXorf57 | | OriGene 3'-UTR Clone for CXorf57 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXorf57 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXorf57 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CXorf57 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXorf57 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf57 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXorf57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXorf57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXorf57 |
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 |  |  |  | |
| | | | Search Tocris compounds for CXorf57 |
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 | | | CXorf57 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf57 |
|  |  |  | | | | Search ThermoFisher Antibodies for CXorf57 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXorf57 |
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