Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CXorf57 Gene

Aliases for CXorf57 Gene

  • Chromosome X Open Reading Frame 57 2 3 5

External Ids for CXorf57 Gene

Previous GeneCards Identifiers for CXorf57 Gene

  • GC0XP105741
  • GC0XP105855
  • GC0XP095482

Summaries for CXorf57 Gene

GeneCards Summary for CXorf57 Gene

CXorf57 (Chromosome X Open Reading Frame 57) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf57 Gene

Genomics for CXorf57 Gene

Regulatory Elements for CXorf57 Gene

Enhancers for CXorf57 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG106725 0.9 ENCODE 11.9 +117.1 117095 6.5 ELF3 TBP FOXA2 ARID4B DMAP1 ZBTB40 ZNF48 RAD21 RARA YY1 RNF128 CXorf57 TBC1D8B GC0XM106712
GH0XG106611 0.8 ENCODE 0.7 +0.4 434 2.2 PKNOX1 ARID4B ZNF121 ZNF366 ZSCAN5C SCRT2 CREM SP3 ZNF398 PRDM6 CXorf57 MIR548AN
GH0XG106608 0.4 ENCODE 0.7 -3.7 -3665 0.2 EP300 CXorf57 GC0XP106598
GH0XG106603 0.3 FANTOM5 0.4 -8.4 -8432 0.1 CLDN2 GC0XP106598 CXorf57
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXorf57 on UCSC Golden Path with GeneCards custom track

Promoters for CXorf57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247805 471 1999 PKNOX1 ARID4B ZNF121 ZNF366 ZSCAN5C SCRT2 CREM SP3 ZNF398 PRDM6

Genomic Location for CXorf57 Gene

Chromosome:
X
Start:
106,611,930 bp from pter
End:
106,679,443 bp from pter
Size:
67,514 bases
Orientation:
Plus strand

Genomic View for CXorf57 Gene

Genes around CXorf57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf57 Gene

Proteins for CXorf57 Gene

  • Protein details for CXorf57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSI4-CX057_HUMAN
    Recommended name:
    Uncharacterized protein CXorf57
    Protein Accession:
    Q6NSI4
    Secondary Accessions:
    • H7BY89
    • Q4G0L7
    • Q5JQS1
    • Q5JRF9
    • Q6PHY5
    • Q6PII9
    • Q6PJU8
    • Q9H7W5
    • Q9NWA6

    Protein attributes for CXorf57 Gene

    Size:
    855 amino acids
    Molecular mass:
    97554 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CXorf57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf57 Gene

Post-translational modifications for CXorf57 Gene

  • Ubiquitination at isoforms=2, 3, 4454, isoforms=2483, Lys624, Lys648, Lys651, isoforms=3, 4689, and isoforms=3, 4817
  • Modification sites at PhosphoSitePlus

Other Protein References for CXorf57 Gene

No data available for DME Specific Peptides for CXorf57 Gene

Domains & Families for CXorf57 Gene

Protein Domains for CXorf57 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXorf57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf57: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CXorf57 Gene

Function for CXorf57 Gene

Gene Ontology (GO) - Molecular Function for CXorf57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CXorf57: view
genes like me logo Genes that share phenotypes with CXorf57: view

Animal Model Products

CRISPR Products

miRNA for CXorf57 Gene

miRTarBase miRNAs that target CXorf57

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf57 Gene

Localization for CXorf57 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf57 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CXorf57 Gene

Pathways & Interactions for CXorf57 Gene

SuperPathways for CXorf57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CXorf57 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf57 Gene

Drugs & Compounds for CXorf57 Gene

No Compound Related Data Available

Transcripts for CXorf57 Gene

Unigene Clusters for CXorf57 Gene

Chromosome X open reading frame 57:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf57 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - -
SP2: - - - - -
SP3:
SP4:
SP5: -

Relevant External Links for CXorf57 Gene

GeneLoc Exon Structure for
CXorf57
ECgene alternative splicing isoforms for
CXorf57

Expression for CXorf57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf57 Gene

mRNA differential expression in normal tissues according to GTEx for CXorf57 Gene

This gene is overexpressed in Brain - Hypothalamus (x8.1) and Pituitary (x6.6).

Protein differential expression in normal tissues from HIPED for CXorf57 Gene

This gene is overexpressed in Stomach (17.3), Lung (12.7), Kidney (12.1), Fetal Brain (9.5), and Esophagus (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CXorf57 Gene



NURSA nuclear receptor signaling pathways regulating expression of CXorf57 Gene:

CXorf57

SOURCE GeneReport for Unigene cluster for CXorf57 Gene:

Hs.274267

Evidence on tissue expression from TISSUES for CXorf57 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CXorf57: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf57 Gene

Orthologs for CXorf57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXHXorf57 34
  • 98 (n)
CXorf57 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXHXorf57 34
  • 88.77 (n)
CXorf57 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC680663 34
  • 83.49 (n)
cow
(Bos Taurus)
Mammalia CXHXorf57 34
  • 82.96 (n)
CXorf57 35
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D330045A20Rik 16 35 34
  • 82.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves C4HXORF57 34
  • 59.69 (n)
CXorf57 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498514 34
  • 55.5 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-26b3.2 34
  • 48.13 (n)
C5HXorf57 35
  • 33 (a)
OneToOne
Species where no ortholog for CXorf57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf57 Gene

ENSEMBL:
Gene Tree for CXorf57 (if available)
TreeFam:
Gene Tree for CXorf57 (if available)

Paralogs for CXorf57 Gene

No data available for Paralogs for CXorf57 Gene

Variants for CXorf57 Gene

Sequence variations from dbSNP and Humsavar for CXorf57 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000081101 -- 106,614,521(+) TTGAA(C/T)GGCTT intron-variant
rs1000213973 -- 106,634,633(+) CAAAC(C/T)TCACC intron-variant
rs1000321538 -- 106,631,195(+) ACATA(A/G)TCAAT intron-variant
rs1000335469 -- 106,661,316(+) TGTCA(C/T)ATATA intron-variant
rs1000366615 -- 106,662,077(+) GGTGG(A/G)AGAGT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CXorf57 Gene

Variant ID Type Subtype PubMed ID
esv2752312 CNV gain 17911159

Variation tolerance for CXorf57 Gene

Residual Variation Intolerance Score: 8.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXorf57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf57 Gene

Disorders for CXorf57 Gene

Relevant External Links for CXorf57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXorf57

No disorders were found for CXorf57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf57 Gene

Publications for CXorf57 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64
  5. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. (PMID: 24550385) Abu-Odeh M. … Aqeilan R.I. (J. Biol. Chem. 2014) 3 64

Products for CXorf57 Gene

Sources for CXorf57 Gene

Content
Loading form....