CXorf56 Gene
protein-coding GIFtS : 43
GCID: GC0X M118672
chromosome X open reading frame 56
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Aliasesfor CXorf56 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome X Open Reading Frame 56 1 2 FLJ229651 UPF0428 Protein CXorf562
Export aliases for CXorf56 gene to outside databases Previous GC identifers: GC0XM118556 GC0XM108165
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Summariesfor CXorf56 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CXorf56 : While this gene is well-supported by transcript data, no functional information on its protein products is currently available. Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2009)
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Genomic Viewsfor CXorf56 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011786.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CXorf56 gene promoter: MEF-2 AP-2gamma MEF-2A FOXJ2 (long isoform) AP-2beta FOXJ2 aMEF-2 AP-2alpha AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for CXorf56 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf56
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq23 Ensembl cytogenetic band: Xq24 HGNC cytogenetic band: Xq24 CXorf56 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM118672: view genomic region
(about GC identifiers )
Start:
118,672,112 bp from pter
End:
118,699,397 bp from pter
Size:
27,286 bases
Orientation:
minus strand
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Proteinsfor CXorf56 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CX056_HUMAN, Q9H5V9 (See
protein sequence )Recommended Name: UPF0428 protein CXorf56 Size : 222 amino acids; 25625 Da
Caution : May be duplicated on chromosome 8, within an intron of the ERLIN2 gene
Sequence caution : Sequence=AAB96348.1; Type=Erroneous gene model prediction;
Secondary accessions : A8MPX7 B4DQN2 D3DWH9 F5GWL7 O43351Alternative splicing : 3 isoforms : Q9H5V9-1 Q9H5V9-2 Q9H5V9-3 Explore the universe of human proteins at neXtProt for CXorf56: NX_Q9H5V9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H5V9 CXorf56 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001164040.1 NP_001164041.1 NP_071384.1 ENSEMBL proteins: ENSP00000420787 ENSP00000320345 ENSP00000420635 ENSP00000360652 ENSP00000441786 Human Recombinant Protein Products: CXorf56 Antibody Products: Assay Products for CXorf56:
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Protein
Domains / Familiesfor CXorf56 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q9H5V9
1 Blocks protein family : IPB003746 Protein of unknown function DUF167 UniProtKB/Swiss-Prot: CX056_HUMAN, Q9H5V9 Similarity : Belongs to the UPF0428 family
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Functionfor CXorf56 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CXorf56 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CXorf56 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): CXorf56 (NM_022101 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXorf56 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CXorf56
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf56
Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for C330007P06Rik) :
CXorf56 for phenotypes About GeneDecksing
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Pathways & Interactionsfor CXorf56 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXorf56 STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/7 Interacting proteins for CXorf56 (Q9H5V9 1 , 2 , 3 ENSP00000360652 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 7 )About this table
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Drugs & Compoundsfor CXorf56 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CXorf56 Search CenterWatch for drugs/clinical trials and news about CXorf56 / CX056
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Transcriptsfor CXorf56 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CXorf56 gene (3 alternative transcripts): NM_001170569.1 NM_001170570.1 NM_022101.3 Unigene Cluster for CXorf56:
Chromosome X open reading frame 56 Hs.248572 [show with all ESTs ] Unigene Representative Sequence: NM_001170569 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000486230 ENST00000320339 (uc004erj.2 ) ENST00000476164 ENST00000469448 ENST00000371594 (uc004erk.2 ) ENST00000536133 (uc011mtu.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CXorf56 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CXorf56 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): CXorf56 (NM_022101 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXorf56 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CXorf56
Additional cDNA sequence: AK096297.1 AK298877.1
9 DOTS entries : DT.435130 DT.100025376
DT.91755382 DT.100697914 DT.121289973 DT.100685266 DT.102823753 DT.92432771 DT.95268685 24/117 AceView cDNA sequences (see all 117 ):
BX092669 BE902841 BQ935396 AW817149 BE155819 BG481619 BG281988 BG778752 BV196334 BM557169 BU958751 BG476516 BM907982 BG421690 BQ223940 BF725548 CB152011 AI676010 BX283804 BP380096 BE379026 BE386158 CB122543 BM474690 GeneLoc Exon Structure
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Expression for CXorf56 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CXorf56 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGCAAGAGGC
About this image CXorf56 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor W10 (Embryonic Progenitor Cell)Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See CXorf56 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CXorf56 SOURCE GeneReport for Unigene cluster: Hs.248572 SABiosciences Custom PCR Arrays for CXorf56 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CXorf56Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CXorf56 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CXorf56 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CXorf56 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf56
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Orthologsfor CXorf56 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for CXorf56 gene from 8/26 species (see all 26 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
C330007P06Rik1 , 5
RIKEN cDNA C330007P06 gene1, 5
92.04(n) 1 99.55(a) 1
 
X (21.23 cM) 5 77644 1 NM_029951.1 1 NP_084227.1 1 36823737 5
chicken (Gallus gallus)
Aves
C4HXorf561
chromosome 4 open reading frame, human CXorf56
82.58(n) 95.05(a)
 
428719 XM_426277.3 XP_426277.2
African clawed frog (Xenopus laevis)
Amphibia
c330007p06-A-prov2
hypothetical protein RIKEN cDNA C330007P06 gene
80.95(n)
 
BC046270.1
zebrafish (Danio rerio)
Actinopterygii
Dr.178872
Transcribed sequence with moderate similarity to protein more
78(n)
 
CK237411.1
fruit fly (Drosophila melanogaster)
Insecta
CG168651
CG16865
55.86(n) 52.78(a)
 
34788 NM_135833.3 NP_609677.1
worm (Caenorhabditis elegans)
Secernentea
Y66D12A.81
Protein Y66D12A.8
54.02(n) 46.55(a)
 
176589 NM_067093.2 NP_499494.1
thale cress (Arabidopsis thaliana)
eudicotyledons
AT5G634406
uncharacterized protein
24(a)
1 ↔ 1
5(25406302-25408423)
rice (Oryza sativa)
Liliopsida
--
uncharacterized ACR, YggU family COG1872 containin...
24(a)
1 ↔ 1
7(11512909-11517213)
ENSEMBL Gene Tree for CXorf56 (if available)TreeFam Gene Tree for CXorf56 (if available)
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Paralogsfor CXorf56 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor CXorf56 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CXorf56 (118672112 - 118699397 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CXorf56: -- Locus Specific Mutation Databases (LSDB): CXorf56
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CXorf56
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Disorders
/ Diseasesfor CXorf56 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor CXorf56 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CXorf56 gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with CXorf56) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PubMed id 19377476) 1 Tarpey P.S.... Stratton M.R. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931) 1 Ewing R.M.... Figeys D. (2007)
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External Searches for CXorf56 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CXorf56 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CXorf56 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CXorf56 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CXorf56 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CXorf56 gene: Search GeneIP for patents involving CXorf56 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CXorf56 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CXorf56 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CXorf56 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CXorf56 OriGene Protein Over-expression Lysate for CXorf56 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CXorf56 OriGene 3'-UTR Clone for CXorf56 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CXorf56 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CXorf56 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CXorf56 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CXorf56 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CXorf56 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf56 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CXorf56 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CXorf56 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CXorf56
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CXorf56 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf56
ThermoFisher Antibodies for CXorf56
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CXorf56
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Aliases for CXorf56
Databases for CXorf56
Disorders / Diseases for CXorf56
Domains / Families for CXorf56
Drugs / Compounds for CXorf56
Expression for CXorf56
Function for CXorf56
Genomic Views for CXorf56
Intellectual Property for CXorf56
Orthologs for CXorf56
Paralogs for CXorf56
Pathways / Interactions for CXorf56
Products for CXorf56
Proteins for CXorf56
Publications for CXorf56
Search Box for CXorf56
Summaries for CXorf56
Transcripts for CXorf56
Variants for CXorf56
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