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Aliases for CXorf56 Gene

Aliases for CXorf56 Gene

  • Chromosome X Open Reading Frame 56 2 3 5

External Ids for CXorf56 Gene

Previous GeneCards Identifiers for CXorf56 Gene

  • GC0XM118556
  • GC0XM118672
  • GC0XM108165

Summaries for CXorf56 Gene

Entrez Gene Summary for CXorf56 Gene

  • While this gene is well-supported by transcript data, no functional information on its protein products is currently available. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for CXorf56 Gene

CXorf56 (Chromosome X Open Reading Frame 56) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf56 Gene

Genomics for CXorf56 Gene

Regulatory Elements for CXorf56 Gene

Enhancers for CXorf56 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF119512 0.8 Ensembl ENCODE 33.1 +52.9 52942 0.6 CTCF ZNF654 ARID4B ZNF384 REST RAD21 ZNF121 SMC3 BCL6 CXorf56 SLC25A43 SLC25A5 SLC25A5-AS1 ENSG00000237903 RNU1-67P ENSG00000226661 GC0XM119539 GC0XM119476
GH0XF119500 1 Ensembl ENCODE 31.4 +61.8 61848 6.3 ELF3 PKNOX1 DMAP1 RAD21 YY1 ZNF121 CREM MIXL1 MIER1 REST CXorf56 SLC25A43 SLC25A5 GC0XM119476 GC0XM119539
GH0XF119529 0.2 Ensembl 25 +35.4 35434 0.8 SPI1 CXorf56 SLC25A5 GC0XM119539 GC0XM119476
GH0XF119572 1 ENCODE 22.3 -9.0 -9035 3.0 WRNIP1 ARID4B SIN3A ZNF2 SP3 REST KAT8 SREBF1 ZNF610 SMARCA4 CXorf56 RPL39 UBE2A GC0XP119576 GC0XP119575
GH0XF119493 0.9 Ensembl ENCODE 21.5 +69.9 69936 4.3 DMAP1 ZNF48 RAD21 RARA ZNF654 CEBPA HNF4A MYC CTCF SOX13 SLC25A43 CXorf56 SLC25A5 SLC25A5-AS1 ENSG00000226661 GC0XM119476 GC0XM119539
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CXorf56 on UCSC Golden Path with GeneCards custom track

Promoters for CXorf56 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001918593 434 1600 ATF1 ARID4B SIN3A DMAP1 BRCA1 ELK1 NFYC ZHX2 REST TBX21

Genomic Location for CXorf56 Gene

Chromosome:
X
Start:
119,538,149 bp from pter
End:
119,565,434 bp from pter
Size:
27,286 bases
Orientation:
Minus strand

Genomic View for CXorf56 Gene

Genes around CXorf56 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf56 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf56 Gene

Proteins for CXorf56 Gene

  • Protein details for CXorf56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5V9-CX056_HUMAN
    Recommended name:
    UPF0428 protein CXorf56
    Protein Accession:
    Q9H5V9
    Secondary Accessions:
    • A8MPX7
    • B4DQN2
    • D3DWH9
    • F5GWL7
    • O43351

    Protein attributes for CXorf56 Gene

    Size:
    222 amino acids
    Molecular mass:
    25625 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB96348.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CXorf56 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf56 Gene

Post-translational modifications for CXorf56 Gene

  • Ubiquitination at Lys 67, Lys 121, and Lys 128
  • Modification sites at PhosphoSitePlus

Other Protein References for CXorf56 Gene

No data available for DME Specific Peptides for CXorf56 Gene

Domains & Families for CXorf56 Gene

Protein Domains for CXorf56 Gene

Suggested Antigen Peptide Sequences for CXorf56 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H5V9

UniProtKB/Swiss-Prot:

CX056_HUMAN :
  • Belongs to the UPF0428 family.
Family:
  • Belongs to the UPF0428 family.
genes like me logo Genes that share domains with CXorf56: view

No data available for Gene Families for CXorf56 Gene

Function for CXorf56 Gene

Phenotypes for CXorf56 Gene

genes like me logo Genes that share phenotypes with CXorf56: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf56 Gene

Localization for CXorf56 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXorf56 Gene COMPARTMENTS Subcellular localization image for CXorf56 gene
Compartment Confidence
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CXorf56 Gene

Pathways & Interactions for CXorf56 Gene

SuperPathways for CXorf56 Gene

No Data Available

Interacting Proteins for CXorf56 Gene

Gene Ontology (GO) - Biological Process for CXorf56 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf56 Gene

Transcripts for CXorf56 Gene

mRNA/cDNA for CXorf56 Gene

Unigene Clusters for CXorf56 Gene

Chromosome X open reading frame 56:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf56 Gene

No ASD Table

Relevant External Links for CXorf56 Gene

GeneLoc Exon Structure for
CXorf56
ECgene alternative splicing isoforms for
CXorf56

Expression for CXorf56 Gene

mRNA expression in normal human tissues for CXorf56 Gene

Protein differential expression in normal tissues from HIPED for CXorf56 Gene

This gene is overexpressed in Bone (33.7) and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXorf56 Gene



Protein tissue co-expression partners for CXorf56 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CXorf56 Gene:

CXorf56

SOURCE GeneReport for Unigene cluster for CXorf56 Gene:

Hs.248572
genes like me logo Genes that share expression patterns with CXorf56: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CXorf56 Gene

Orthologs for CXorf56 Gene

This gene was present in the common ancestor of animals.

Orthologs for CXorf56 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
CXHXorf56 34
  • 96.49 (n)
-- 35
  • 96 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CXorf56 35
  • 99 (a)
OneToOne
CXHXorf56 34
  • 93.39 (n)
dog
(Canis familiaris)
Mammalia CXorf56 35
  • 95 (a)
OneToOne
CXHXorf56 34
  • 92.34 (n)
oppossum
(Monodelphis domestica)
Mammalia CXorf56 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXorf56 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C330007P06Rik 34 16 35
  • 92.04 (n)
rat
(Rattus norvegicus)
Mammalia RGD1564541 34
  • 91.89 (n)
chicken
(Gallus gallus)
Aves CXorf56 35
  • 95 (a)
OneToOne
CXORF56 34
  • 82.85 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cxorf56 34
  • 79.13 (n)
MGC76077 34
African clawed frog
(Xenopus laevis)
Amphibia c330007p06-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii C5HXorf56 35
  • 88 (a)
OneToOne
zgc:103697 34
  • 77.63 (n)
Dr.17887 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2208 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005769 34
  • 59.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG16865 34 35
  • 58.46 (n)
worm
(Caenorhabditis elegans)
Secernentea Y66D12A.8 34 35
  • 52.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6041 34
Species where no ortholog for CXorf56 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CXorf56 Gene

ENSEMBL:
Gene Tree for CXorf56 (if available)
TreeFam:
Gene Tree for CXorf56 (if available)

Paralogs for CXorf56 Gene

Pseudogenes.org Pseudogenes for CXorf56 Gene

genes like me logo Genes that share paralogs with CXorf56: view

No data available for Paralogs for CXorf56 Gene

Variants for CXorf56 Gene

Sequence variations from dbSNP and Humsavar for CXorf56 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1029630 -- 119,556,975(+) ACGTG(G/T)TGAAA intron-variant
rs10649985 -- 119,553,144(+) AGACT(-/CT)GTCTC intron-variant
rs10907047 -- 119,562,494(+) tgcca(C/T)tgcac intron-variant
rs111444499 -- 119,542,912(+) CTTCC(C/T)GCCTC intron-variant
rs111539730 -- 119,564,503(+) AAAAA(-/G/GG)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf56 Gene

Variant ID Type Subtype PubMed ID
esv3574414 CNV loss 25503493
nsv525652 CNV gain 19592680

Variation tolerance for CXorf56 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXorf56 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf56

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf56 Gene

Disorders for CXorf56 Gene

Relevant External Links for CXorf56

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXorf56

No disorders were found for CXorf56 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf56 Gene

Publications for CXorf56 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. (PMID: 26752685) Scholz C.C. … Taylor C.T. (PLoS Biol. 2016) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for CXorf56 Gene

Sources for CXorf56 Gene

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