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Aliases for CXorf40A Gene

Aliases for CXorf40A Gene

  • Chromosome X Open Reading Frame 40A 2 3
  • Endothelial-Overexpressed Lipopolysaccharide-Associated Factor 1 2 3 4
  • CXorf40 3 4
  • EOLA1 3 4
  • Chromosome X Open Reading Frame 40 2
  • Protein CXorf40A 3

External Ids for CXorf40A Gene

Previous HGNC Symbols for CXorf40A Gene

  • CXorf40

Previous GeneCards Identifiers for CXorf40A Gene

  • GC0XP148328
  • GC0XP148432
  • GC0XP148623
  • GC0XP137575

Summaries for CXorf40A Gene

GeneCards Summary for CXorf40A Gene

CXorf40A (Chromosome X Open Reading Frame 40A) is a Protein Coding gene. Diseases associated with CXorf40A include intrahepatic cholangiocarcinoma. An important paralog of this gene is CXorf40B.

UniProtKB/Swiss-Prot for CXorf40A Gene

  • May have an important role of cell protection in inflammation reaction

Gene Wiki entry for CXorf40A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf40A Gene

Genomics for CXorf40A Gene

Regulatory Elements for CXorf40A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CXorf40A Gene

Start:
149,540,355 bp from pter
End:
149,550,541 bp from pter
Size:
10,187 bases
Orientation:
Plus strand

Genomic View for CXorf40A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXorf40A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf40A Gene

Proteins for CXorf40A Gene

  • Protein details for CXorf40A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE69-CX04A_HUMAN
    Recommended name:
    Protein CXorf40A
    Protein Accession:
    Q8TE69
    Secondary Accessions:
    • A8K784
    • B7Z6H6
    • B7ZL96
    • D6RA72
    • E7ENU3
    • Q2M3E9

    Protein attributes for CXorf40A Gene

    Size:
    158 amino acids
    Molecular mass:
    17921 Da
    Quaternary structure:
    • Interacts with MT2A.

    Alternative splice isoforms for CXorf40A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf40A Gene

Proteomics data for CXorf40A Gene at MOPED

Post-translational modifications for CXorf40A Gene

No Post-translational modifications

No data available for DME Specific Peptides for CXorf40A Gene

Domains for CXorf40A Gene

Protein Domains for CXorf40A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXorf40A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf40A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CXorf40A Gene

Function for CXorf40A Gene

Molecular function for CXorf40A Gene

UniProtKB/Swiss-Prot Function: May have an important role of cell protection in inflammation reaction

Gene Ontology (GO) - Molecular Function for CXorf40A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15541360
genes like me logo Genes that share ontologies with CXorf40A: view

Phenotypes for CXorf40A Gene

GenomeRNAi human phenotypes for CXorf40A:
genes like me logo Genes that share phenotypes with CXorf40A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CXorf40A Gene

Localization for CXorf40A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CXorf40A Gene

Pathways for CXorf40A Gene

SuperPathways for CXorf40A Gene

No Data Available

Interacting Proteins for CXorf40A Gene

Selected Interacting proteins: Q8TE69-CX04A_HUMAN for CXorf40A Gene via UniProtKB I2D

Symbol External ID(s) Details
MT2A

Gene Ontology (GO) - Biological Process for CXorf40A Gene

None

No data available for Pathways by source for CXorf40A Gene

Transcripts for CXorf40A Gene

Unigene Clusters for CXorf40A Gene

Chromosome X open reading frame 40A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXorf40A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CXorf40A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf40A Gene

No ASD Table

Relevant External Links for CXorf40A Gene

GeneLoc Exon Structure for
CXorf40A
ECgene alternative splicing isoforms for
CXorf40A

Expression for CXorf40A Gene

mRNA expression in normal human tissues for CXorf40A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CXorf40A Gene

SOURCE GeneReport for Unigene cluster for CXorf40A Gene Hs.534641

mRNA Expression by UniProt/SwissProt for CXorf40A Gene

Q8TE69-CX04A_HUMAN
Tissue specificity: Expressed primarily in heart, skeletal muscle, kidney, liver and placenta. Relatively high level of expression in spleen, colon and small intestine. Almost no expression in brain, thymus, lung and peripheral blood leukocytes.
genes like me logo Genes that share expressions with CXorf40A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CXorf40A Gene

Orthologs for CXorf40A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf40A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
CXHXorf40A 35
  • 98.31 (n)
  • 97.47 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 78 (a)
ManyToMany
-- 36
  • 78 (a)
ManyToMany
CXHXorf40A 35
  • 80.38 (n)
  • 79.11 (a)
mouse
(Mus musculus)
Mammalia 1110012L19Rik 35
  • 80.68 (n)
  • 77.07 (a)
1110012L19Rik 16
1110012L19Rik 36
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1562747 35
  • 81.53 (n)
  • 80.25 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 64 (a)
OneToMany
LOC772269 35
  • 66.45 (n)
  • 67.32 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.16160 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cxorf40a 35
  • 64.71 (n)
  • 64.05 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1060 35
zebrafish
(Danio rerio)
Actinopterygii C21HXorf40A 36
  • 53 (a)
OneToMany
zgc:110222 35
  • 56.75 (n)
  • 57.59 (a)
Species with no ortholog for CXorf40A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf40A Gene

ENSEMBL:
Gene Tree for CXorf40A (if available)
TreeFam:
Gene Tree for CXorf40A (if available)

Paralogs for CXorf40A Gene

Paralogs for CXorf40A Gene

Selected SIMAP similar genes for CXorf40A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CXorf40A Gene

genes like me logo Genes that share paralogs with CXorf40A: view

Variants for CXorf40A Gene

Sequence variations from dbSNP and Humsavar for CXorf40A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs11987 -- 149,546,820(+) AGCTG(C/T)ACTGA missense, reference
rs471433 -- 149,542,299(-) TCTGA(C/T)GGAGG intron-variant
rs525118 -- 149,543,871(+) AGTGT(A/C/G/T)CCCAG intron-variant, upstream-variant-2KB
rs526046 -- 149,543,765(-) GGCCC(A/G)TACAT intron-variant, upstream-variant-2KB
rs571404 -- 149,544,899(-) CAACT(A/G)GCAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXorf40A Gene

Variant ID Type Subtype PubMed ID
nsv525908 CNV Gain 19592680
nsv518742 CNV Gain 19592680
nsv508809 CNV Insertion 20534489

Relevant External Links for CXorf40A Gene

HapMap Linkage Disequilibrium report
CXorf40A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf40A Gene

Disorders for CXorf40A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CXorf40A Gene including...

Search for CXorf40A Gene in MalaCards »

(2) Novoseek inferred disease relationships for CXorf40A Gene

Disease -log(P) Hits PubMed IDs
inflammation 12.4 2
cancer 0 2
genes like me logo Genes that share disorders with CXorf40A: view

No data available for UniProtKB/Swiss-Prot for CXorf40A Gene

Publications for CXorf40A Gene

  1. Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation. (PMID: 15541360) Liang Z. … Yang Z. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  2. [Purification of human endothelial overexpressed lipopolysaccharide-associated factor 1 protein]. (PMID: 16383041) Cai Z. … Su Y.Y. (Zhonghua Shao Shang Za Zhi 2005) 2 3 23
  3. 130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus. (PMID: 8717057) Timms K.M. … Gibbs R.A. (Genome Res. 1995) 2 3 4
  4. Molecular and phenotypic variation in patients with severe Hunter syndrome. (PMID: 9147653) Timms K.M. … Gibbs R.A. (Hum. Mol. Genet. 1997) 2 3
  5. [The effect of inhibiting EOLA1 expression in ECV304 cells]. (PMID: 17557240) Liang Z.W. … Wang X.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007) 3 23

Products for CXorf40A Gene

Sources for CXorf40A Gene

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