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CXorf38 Gene

protein-coding   GIFtS: 42
GCID: GC0XM040488

Chromosome X Open Reading Frame 38

  Search for CXorf38
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome X Open Reading Frame 381 2
Uncharacterized Protein CXorf382

External Ids:    HGNC: 285891   Entrez Gene: 1590132   Ensembl: ENSG000001857537   UniProtKB: Q8TB033   

Export aliases for CXorf38 gene to outside databases

Previous GC identifers: GC0XM040244 GC0XM040373 GC0XM038197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CXorf38 Gene:
CXorf38 (chromosome X open reading frame 38) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_079573.5  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXorf38 gene promoter:
         SRF   AML1a   STAT5A   AP-4   Meis-1a   CUTL1   Nkx2-5   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXorf38 promoter sequence
   Search Chromatin IP Primers for CXorf38

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXorf38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.4   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp11

CXorf38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf38 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM040488:  view genomic region     (about GC identifiers)

Start:
40,486,173 bp from pter      End:
40,506,819 bp from pter
Size:
20,647 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CX038_HUMAN, Q8TB03 (See protein sequence)
Recommended Name: Uncharacterized protein CXorf38  
Size: 319 amino acids; 36670 Da
Secondary accessions: B3KW28 D3DWB5 Q5JPF5 Q8N941
Alternative splicing: 3 isoforms:  Q8TB03-1   Q8TB03-2   Q8TB03-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CXorf38: NX_Q8TB03

Explore proteomics data for CXorf38 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys20, Lys276
  • Modification sites at PhosphoSitePlus

  • See CXorf38 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_659407.1  
    ENSEMBL proteins: 
     ENSP00000330488   ENSP00000367683   ENSP00000367677   ENSP00000400019   ENSP00000367674  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027897 DUF4559

    Graphical View of Domain Structure for InterPro Entry Q8TB03

    ProtoNet protein and cluster: Q8TB03


    CXorf38 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for CXorf38:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXorf38
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    hsa-miR-203 hsa-miR-607 hsa-miR-3606 hsa-miR-513a-3p hsa-miR-708* hsa-miR-513c hsa-miR-507 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidCXorf38 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CXorf38
    Interactions:

        Search GeneGlobe Interaction Network for CXorf38

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXorf38 (CX038)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CXorf38 gene: 
    NM_144970.2  

    Unigene Cluster for CXorf38:

    Chromosome X open reading frame 38
    Hs.495961  [show with all ESTs]
    Unigene Representative Sequence: NM_144970
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327877 ENST00000378426(uc004dev.1 uc004dew.3 uc011mko.2)
    ENST00000378421(uc010nhd.3) ENST00000440784 ENST00000378418
    miRNA
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    hsa-miR-203 hsa-miR-607 hsa-miR-3606 hsa-miR-513a-3p hsa-miR-708* hsa-miR-513c hsa-miR-507 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidCXorf38 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat CXorf38

    Additional mRNA sequence: 

    AK021629.1 AK123989.1 AK304539.1 AK315384.1 BC025334.1 

    5 DOTS entries:

    DT.97836851  DT.455244  DT.75100355  DT.100018985  DT.100775019 

    Selected AceView cDNA sequences (see all 82):

    AK123989 AW516217 AI261614 CB528677 AI859061 AI299422 AA282360 AI288711 
    BM791996 NM_144970 BG058514 AA437393 BU633367 BF589564 BM052674 CA312886 
    CB529086 BC025334 CA417909 BF001685 BG538379 AI307216 BQ082269 BM052934 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CXorf38    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                          -                                       
    SP2:                                                                  
    SP3:                    -     -                                       
    SP4:                                                                  


    ECgene alternative splicing isoforms for CXorf38

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXorf38 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CXorf38 Expression
    About this image

    CXorf38 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXorf38 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495961
        Custom PCR Arrays for CXorf38
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXorf38 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1810030O07Rik1 , 5 RIKEN cDNA 1810030O07 gene1, 5 85.89(n)1
    86.52(a)1
      X (7.50 cM)5
    691551  NM_175141.51  NP_780350.11 
     126548795 
    lizard
    (Anolis carolinensis)
    Reptilia CXorf386
    chromosome X open reading frame 38
    49(a)
    1 ↔ 1
    3(133826376-133840810)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.337192 Xenopus laevis transcribed sequences 77.1(n)    BI477917.1 
    zebrafish
    (Danio rerio)
    Actinopterygii C25HXorf38 (1 of 2)6
    C25HXorf38 (2 of 2)6
    chromosome X open reading frame 38
    2(a)
    1(a)
    many → 1
    many → 1
    25(28581636-28602467) ENSDARG00000036888
    25(28495710-28532682) ENSDARG00000089227


    ENSEMBL Gene Tree for CXorf38 (if available)
    TreeFam Gene Tree for CXorf38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXorf38 (see all 349)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895025461,2
    --40485873(+) AAGAAC/TAGGCT 1 -- int10--------
    rs128504971,2
    C,H--40486038(+) AGACAG/TCCCTA 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1392853571,2
    --40486080(+) CCCACA/GACCCT 1 -- int10--------
    rs1818835701,2
    --40486355(+) AAAAAA/GCTGGG 1 -- ut310--------
    rs1440776511,2
    --40486402(+) AAACAC/TAAAGA 1 -- ut310--------
    rs3688905551,2
    C--40486428(+) TATGC-/TTTTTTTT 1 -- cds10--------
    rs582876401,2
    C--40486436(+) TTTTT-/TTTG  
            
    GGGGG
    1 -- ut310--------
    rs1995591521,2
    --40486437(+) TTTTT-/TTGG  
            
    GGGGG
    1 -- ut310--------
    rs11363631,2
    C--40486501(-) CACACA/CACTGC 1 -- ut310--------
    rs1834804421,2
    --40486640(+) GTTTCA/GCCACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CXorf38 (40486173 - 40506819 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CXorf38:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2550325CNV Deletion19546169
    esv2740109CNV Deletion23290073
    esv33829CNV Loss17666407
    esv5571CNV Loss19470904
    nsv518965CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): CXorf38

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CXorf38

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXorf38 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CXorf38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 159013 HGNC: 28589 AceView: CXorf38 Ensembl:ENSG00000185753 euGenes: HUgn159013
    ECgene: CXorf38 H-InvDB: CXorf38

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXorf38 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXorf38 gene:
    Search GeneIP for patents involving CXorf38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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