CXorf36 Gene
protein-coding GIFtS: 39
GCID: GC0XM045007
|
|
chromosome X open reading frame 36
| |
Aliases
for CXorf36 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome X Open Reading Frame 361 2 | | BA435K1.11 | | DIA1R1 2 3 | | Deleted In Autism-1 Related Protein2 | | FLJ141031 | | Deleted In Autism-Related Protein 12 | | 4930578C19Rik2 | | HCG19816351 | | EPQL18622 | | UPF0672 Protein CXorf362 | | PRO37432 | | |
Export aliases for CXorf36 gene to outside databasesPrevious GC identifers: GC0XM044765 GC0XM044892 GC0XM042724 |
Summaries
for CXorf36 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for CXorf36
|
Genomic Views
for CXorf36 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CXorf36 gene promoter:
HOXA9 E2F E2F-1 POU2F1 POU2F1b POU2F1a POU2F1c Nkx2-5
Other transcription factors
Search SABiosciences Chromatin IP Primers for CXorf36
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf36 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.3 Ensembl cytogenetic band: Xp11.3 HGNC cytogenetic band: Xp11.3-p11.23CXorf36 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM045007: view genomic region
(about GC identifiers)
Start:
|
45,007,618 bp from pter |
End:
|
45,060,146 bp from pter |
Size:
|
52,529 bases |
Orientation:
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minus strand |
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Proteins
for CXorf36 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DIA1R_HUMAN, Q9H7Y0 (See
protein sequence)Recommended Name: Deleted in autism-related protein 1 precursor Size: 433 amino acids; 48555 Da
Subcellular location: Secreted (Potential)
Secondary accessions: A8MUU5 B2RPN7 Q6UWJ5Alternative splicing: 2 isoforms: Q9H7Y0-1 Q9H7Y0-2 Explore the universe of human proteins at neXtProt for CXorf36: NX_Q9H7Y0
CXorf36 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_078965.2 NP_789789.2
ENSEMBL proteins: ENSP00000381086 ENSP00000367168
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CXorf36 for ontologies About GeneDecksing
CXorf36 Antibody Products:
Assay Products for CXorf36: |
Protein
Domains /
Families
for CXorf36 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CXorf36 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H7Y0ProtoNet protein and cluster: Q9H7Y0 UniProtKB/Swiss-Prot: DIA1R_HUMAN, Q9H7Y0Similarity: Belongs to the DIA1 family |
Function
for CXorf36 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXorf36 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXorf36 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CXorf36 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CXorf36 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf36 |
|
Pathways & Interactions
for CXorf36 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXorf36
|
Drugs & Compounds
for CXorf36 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CXorf36
Search CenterWatch for drugs/clinical trials and news about CXorf36 / DIA1R
|
Transcripts
for CXorf36 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CXorf36 gene (2 alternative transcripts): NM_024689.2 NM_176819.3 Unigene Cluster for CXorf36: Chromosome X open reading frame 36 Hs.98321 [show with all ESTs]Unigene Representative Sequence: NM_1768194 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398000(uc004dgg.2) ENST00000477281 ENST00000377934(uc004dgi.3)
ENST00000492138
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXorf36 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXorf36 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CXorf36 (NM_024689) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXorf36 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CXorf36 |
Additional cDNA sequence: AF289581.1 AK024165.1 AK055190.1 AK056730.1 AK094014.1 AK094877.1 AK294472.1 AY358764.1 BC035375.1 BC137528.1 BC137529.1 CR627166.1 8 DOTS entries: DT.408343 DT.95259719 DT.91702422 DT.121311539 DT.121311588 DT.121311540 DT.121311593 DT.95207424 24/92 AceView cDNA sequences (see all 92): AI796127 BC035375 BF437818 AA716537 F10489 BF197767 Z41334 T26963 AA776217 BM955835 F01640 AY358764 AI554899 W63748 BE673577 AI223791 AI095506 AK024165 AU121832 BF446881 Z45663 AL703040 CR627166 F05387
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CXorf36 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CXorf36
|
Expression
for CXorf36 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CXorf36 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGGAAGCT
About this image
See CXorf36 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXorf36
SOURCE GeneReport for Unigene cluster: Hs.98321
SABiosciences Custom PCR Arrays for CXorf36
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXorf36
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXorf36 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXorf36 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXorf36 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf36 |
Orthologs
for CXorf36 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CXorf36 gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
C1HXorf361 |
chromosome 1 open reading frame, human CXorf36 |
68.52(n)
67.39(a) |
|
418555 XM_416761.3 XP_416761.3 |
lizard
(Anolis carolinensis) |
Reptilia |
CXorf366 |
-- |
67(a) |
1 ↔ 1 |
3(135791376-135825920) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5692321 |
UPF0672 protein CXorf36 homolog |
55.85(n)
49.48(a) |
|
569232 XM_692604.4 XP_697696.2 |
ENSEMBL Gene Tree for CXorf36 (if available)
TreeFam Gene Tree for CXorf36 (if available) |
Paralogs
for CXorf36 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CXorf36 gene
- C3orf582
1 SIMAP similar gene for CXorf36 using alignment to 1 protein entry: DIA1R_HUMAN:C3orf58
CXorf36 for paralogs About GeneDecksing
|
Genomic Variants
for CXorf36 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CXorf36 (45007618 - 45060146 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CXorf36: --
Locus Specific Mutation Databases (LSDB): CXorf36
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXorf36 |
|
Disorders
/ Diseases
for CXorf36 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CXorf36 for disorders About MalaCards
CXorf36 for disorders About GeneDecksing
UniProtKB/Swiss-Prot: DIA1R_HUMAN, Q9H7Y0
Note=Genetic variations in CXorf36 may be associated with susceptibility to autism
Export disorders for CXorf36 gene to outside databases
|
Publications
for CXorf36 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CXorf36 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CXorf36) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the deleted in autism 1 protein f amily: implications for studying cognitive disorders. (PubMed id 21283809)1, 3 Aziz A....Bishop N.E. (2011)
- DIA1R is an X-linked gene related to Deleted In Autis m-1. (PubMed id 21264219)1, 2 Aziz A....Bishop N.E. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PubMed id 11944989)1, 3 Thiselton D.L.... Meindl A. (2002)
- A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PubMed id 19377476)1 Tarpey P.S.... Stratton M.R. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
|
External Searches for CXorf36 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CXorf36 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CXorf36 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CXorf36 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CXorf36 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CXorf36 gene:
Search GeneIP for patents involving CXorf36
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CXorf36 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CXorf36 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXorf36 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf36 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXorf36 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXorf36 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXorf36 |
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 | | | CXorf36 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf36 |
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