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Aliases for CXorf36 Gene

Aliases for CXorf36 Gene

  • Chromosome X Open Reading Frame 36 2 3 5
  • DIA1R 3 4
  • Deleted In Autism-1 Related Protein 3
  • Deleted In Autism-Related Protein 1 3
  • UPF0672 Protein CXorf36 3
  • 4930578C19Rik 3
  • HCG1981635 3
  • BA435K1.1 3
  • EPQL1862 3
  • PRO3743 3

External Ids for CXorf36 Gene

Previous GeneCards Identifiers for CXorf36 Gene

  • GC0XM044765
  • GC0XM044892
  • GC0XM045007
  • GC0XM042724

Summaries for CXorf36 Gene

GeneCards Summary for CXorf36 Gene

CXorf36 (Chromosome X Open Reading Frame 36) is a Protein Coding gene. An important paralog of this gene is C3orf58.

Gene Wiki entry for CXorf36 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf36 Gene

Genomics for CXorf36 Gene

Regulatory Elements for CXorf36 Gene

Enhancers for CXorf36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG045199 0.5 FANTOM5 13.5 +2.0 2005 0.3 GATA2 POLR2A ATF2 CXorf36 LOC105373191
GH0XG045198 0.5 FANTOM5 13.4 +2.4 2395 0.2 GATA2 POLR2A CXorf36 LOC105373191
GH0XG044973 1 Ensembl ENCODE 6.2 +225.8 225788 2.4 TFAP4 KLF1 JUN HIC1 GATA2 ZNF169 FOS GATAD2A ZNF680 FOXA3 CXorf36 KDM6A GC0XP045033
GH0XG045191 0.8 Ensembl ENCODE 5.9 +9.2 9198 1.0 ZNF202 IKZF1 IKZF2 TBX21 CXorf36 LOC105373191
GH0XG045128 0.4 ENCODE 11.6 +71.8 71846 1.7 ZNF316 MAFK CXorf36 LOC105373191 GC0XP045033
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXorf36 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXorf36 Gene

Chromosome:
X
Start:
45,148,373 bp from pter
End:
45,200,901 bp from pter
Size:
52,529 bases
Orientation:
Minus strand

Genomic View for CXorf36 Gene

Genes around CXorf36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf36 Gene

Proteins for CXorf36 Gene

  • Protein details for CXorf36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7Y0-DIA1R_HUMAN
    Recommended name:
    Deleted in autism-related protein 1
    Protein Accession:
    Q9H7Y0
    Secondary Accessions:
    • A8MUU5
    • B2RPN7
    • Q6UWJ5

    Protein attributes for CXorf36 Gene

    Size:
    433 amino acids
    Molecular mass:
    48555 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CXorf36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf36 Gene

Post-translational modifications for CXorf36 Gene

Other Protein References for CXorf36 Gene

No data available for DME Specific Peptides for CXorf36 Gene

Domains & Families for CXorf36 Gene

Protein Domains for CXorf36 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXorf36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7Y0

UniProtKB/Swiss-Prot:

DIA1R_HUMAN :
  • Belongs to the DIA1 family.
Family:
  • Belongs to the DIA1 family.
genes like me logo Genes that share domains with CXorf36: view

No data available for Gene Families for CXorf36 Gene

Function for CXorf36 Gene

genes like me logo Genes that share phenotypes with CXorf36: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf36 Gene

Localization for CXorf36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXorf36 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf36 gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CXorf36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CXorf36: view

Pathways & Interactions for CXorf36 Gene

SuperPathways for CXorf36 Gene

No Data Available

Interacting Proteins for CXorf36 Gene

Selected Interacting proteins: Q9H7Y0-DIA1R_HUMAN for CXorf36 Gene via IID

Gene Ontology (GO) - Biological Process for CXorf36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009966 regulation of signal transduction IBA --
genes like me logo Genes that share ontologies with CXorf36: view

No data available for Pathways by source and SIGNOR curated interactions for CXorf36 Gene

Drugs & Compounds for CXorf36 Gene

No Compound Related Data Available

Transcripts for CXorf36 Gene

Unigene Clusters for CXorf36 Gene

Chromosome X open reading frame 36:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf36 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5: - - - - -
SP6: - - - - - - - -
SP7:

Relevant External Links for CXorf36 Gene

GeneLoc Exon Structure for
CXorf36
ECgene alternative splicing isoforms for
CXorf36

Expression for CXorf36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf36 Gene

Protein differential expression in normal tissues from HIPED for CXorf36 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXorf36 Gene



Protein tissue co-expression partners for CXorf36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CXorf36 Gene:

CXorf36

SOURCE GeneReport for Unigene cluster for CXorf36 Gene:

Hs.98321

Evidence on tissue expression from TISSUES for CXorf36 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with CXorf36: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf36 Gene

Orthologs for CXorf36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXHXorf36 34
  • 99.46 (n)
CXorf36 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXHXorf36 34
  • 86.37 (n)
CXorf36 35
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXHXorf36 34 35
  • 85.14 (n)
mouse
(Mus musculus)
Mammalia 4930578C19Rik 34 16 35
  • 83.76 (n)
rat
(Rattus norvegicus)
Mammalia RGD1559731 34
  • 81.79 (n)
oppossum
(Monodelphis domestica)
Mammalia CXorf36 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXorf36 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1HXORF36 34
  • 67.87 (n)
CXorf36 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXorf36 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch73-147f11.1 34
  • 55.85 (n)
C9HXorf36 35
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToMany
Species where no ortholog for CXorf36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf36 Gene

ENSEMBL:
Gene Tree for CXorf36 (if available)
TreeFam:
Gene Tree for CXorf36 (if available)

Paralogs for CXorf36 Gene

Paralogs for CXorf36 Gene

(1) SIMAP similar genes for CXorf36 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CXorf36: view

Variants for CXorf36 Gene

Sequence variations from dbSNP and Humsavar for CXorf36 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000015820 -- 45,174,940(+) CTACA(A/G)GGAAG intron-variant
rs1000054423 -- 45,161,114(+) TGCTC(A/G)GGCAG intron-variant
rs1000203805 -- 45,186,130(+) GATAG(C/T)AAAGT intron-variant
rs1000297403 -- 45,165,371(+) AAAAC(C/T)ACTCT intron-variant
rs1000358348 -- 45,191,629(+) TTTGT(C/G)ACACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf36 Gene

Variant ID Type Subtype PubMed ID
esv3558843 CNV deletion 23714750
nsv508765 CNV insertion 20534489
nsv524833 CNV gain 19592680

Variation tolerance for CXorf36 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.81; 91.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXorf36 Gene

Human Gene Mutation Database (HGMD)
CXorf36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf36 Gene

Disorders for CXorf36 Gene

UniProtKB/Swiss-Prot

DIA1R_HUMAN
  • Note=Genetic variations in CXorf36 may be associated with susceptibility to autism. {ECO:0000269 PubMed:21264219}.

Relevant External Links for CXorf36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXorf36

No disorders were found for CXorf36 Gene.

No data available for MalaCards and Genatlas for CXorf36 Gene

Publications for CXorf36 Gene

  1. A novel predicted calcium-regulated kinase family implicated in neurological disorders. (PMID: 23840464) Dudkiewicz M. … PawA8owski K. (PLoS ONE 2013) 2 3 64
  2. Characterization of the deleted in autism 1 protein family: implications for studying cognitive disorders. (PMID: 21283809) Aziz A. … Bishop N.E. (PLoS ONE 2011) 2 3 64
  3. DIA1R is an X-linked gene related to Deleted In Autism-1. (PMID: 21264219) Aziz A. … Bishop N.E. (PLoS ONE 2011) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for CXorf36 Gene

Sources for CXorf36 Gene

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