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CXorf30 Gene

protein-coding   GIFtS: 38
GCID: GC0XP036240          (predicted)

Chromosome X Open Reading Frame 30

  Search for CXorf30
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome X Open Reading Frame 301 2
Putative Uncharacterized Protein CXorf302

External Ids:    HGNC: 272981   Entrez Gene: 6450902   Ensembl: ENSG000002050817   UniProtKB: A6PW823   

Export aliases for CXorf30 gene to outside databases

Previous GC identifers: GC0XU900740 GC0XP036157 GC0XP036195 GC0XP033995


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CXorf30 Gene:
CXorf30 (chromosome X open reading frame 30) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXorf30 gene promoter:
         MEF-2A   Pbx1a   POU3F1   aMEF-2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CXorf30

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXorf30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp21.1   HGNC cytogenetic band: Xp21.1

CXorf30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf30 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP036240:  view genomic region     (about GC identifiers)

Start:
36,246,735 bp from pter      End:
36,403,434 bp from pter
Size:
156,700 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CX030_HUMAN, A6PW82 (See protein sequence)
Recommended Name: Putative uncharacterized protein CXorf30  
Size: 633 amino acids; 72017 Da
Sequence caution: Sequence=CAO72050.2; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for CXorf30: NX_A6PW82

Explore proteomics data for CXorf30 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CXorf30 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001092313.2  
    ENSEMBL proteins: 
     ENSP00000367922   ENSP00000367926  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: A6PW82


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
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    hsa-miR-3919
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CXorf30
    Interactions:

        Search GeneGlobe Interaction Network for CXorf30

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXorf30 (CX030)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CXorf30 gene: 
    NM_001098843.4  

    Unigene Cluster for CXorf30:

    Chromosome X open reading frame 30
    Hs.632791  [show with all ESTs]
    Unigene Representative Sequence: NM_001098843
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378653 ENST00000446478 ENST00000378657(uc011mkc.2)
    miRNA
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    hsa-miR-3919
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CXorf30

    3 DOTS entries:

    DT.70101267  DT.75155906  DT.121284418 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXorf30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAAAAAA
    CXorf30 Expression
    About this image

    CXorf30 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXorf30 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632791
        Custom PCR Arrays for CXorf30
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXorf30 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm87875
    Gm164621
    predicted gene 87875
    predicted gene 164621
    72.99(n)1
    59.49(a)1
      X (38.37 cM)5
    6360821  XM_006528359.11  XP_006528422.11 
     793305135 
    chicken
    (Gallus gallus)
    Aves CXorf306
    chromosome X open reading frame 30
    47(a)
    1 ↔ 1
    1(112906641-112985873)
    lizard
    (Anolis carolinensis)
    Reptilia CXorf306
    chromosome X open reading frame 30
    31(a)
    1 ↔ 1
    3(131560407-131567992)


    ENSEMBL Gene Tree for CXorf30 (if available)
    TreeFam Gene Tree for CXorf30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CXorf30 gene

    Find genes that share paralogs with CXorf30           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CXorf30
    PGOHUM00000241230


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXorf30 (see all 2100)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59021261,2
    C--34125293(+) TGTGC-/ATAT  
            
    atata
    1 -- int10--------
    rs1432026251,2
    --36244959(+) TGATTA/GTGTAG 1 -- us2k10--------
    rs1846094141,2
    --36244982(+) AGAGGG/TTTTTA 1 -- us2k10--------
    rs1467757731,2
    C--36245424(+) ATACAA/GATTTC 1 -- us2k10--------
    rs731971911,2
    C--36245431(+) TTTCAA/GATATT 1 -- us2k10--------
    rs1889328381,2
    --36245562(+) GATATA/GTAACA 1 -- us2k10--------
    rs1996304371,2
    --36245627(+) TAGGG-/TAGT  
            
    TAATG
    1 -- us2k10--------
    rs1918133311,2
    --36246130(+) TTATGA/GGAAGT 1 -- us2k10--------
    rs1845561391,2
    --36246288(+) CTAATA/GTTGCA 1 -- us2k10--------
    rs59720311,2
    C,F,A,H--36246532(+) GAGCAC/GACTGT 1 -- us2k19Minor allele frequency- G:0.25NS EA NA WA CSA 561

    HapMap Linkage Disequilibrium report for CXorf30 (36246735 - 36403434 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CXorf30:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740088CNV Deletion23290073
    esv268765CNV Insertion20981092
    nsv470349CNV Gain18288195

    Locus Specific Mutation Databases (LSDB): CXorf30

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXorf30
    DNA2.0 Custom Variant and Variant Library Synthesis for CXorf30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CXorf30           About GenesLikeMe

    Genetic Association Database (GAD): CXorf30

    Export disorders for CXorf30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXorf30 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CXorf30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (Nat. Biotechnol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 645090 HGNC: 27298 Ensembl:ENSG00000205081 euGenes: HUgn645090 ECgene: CXorf30
    H-InvDB: CXorf30

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXorf30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXorf30 gene:
    Search GeneIP for patents involving CXorf30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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