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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXorf30 Gene

protein-coding   GIFtS: 33
GCID: GC0XP036240          (predicted)

Chromosome X Open Reading Frame 30

  Search for CXorf30
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome X Open Reading Frame 301 2
Putative Uncharacterized Protein CXorf302

External Ids:    HGNC: 272981   Entrez Gene: 6450902   Ensembl: ENSG000002050817   UniProtKB: A6PW823   

Export aliases for CXorf30 gene to outside databases

Previous GC identifers: GC0XU900740 GC0XP036157 GC0XP036195 GC0XP033995


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CXorf30 Gene: 
CXorf30 (chromosome X open reading frame 30) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXorf30 gene promoter:
         MEF-2A   Pbx1a   POU3F1   aMEF-2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CXorf30

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp21.1   HGNC cytogenetic band: Xp21.1

CXorf30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf30 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP036240:  view genomic region     (about GC identifiers)

Start:
36,246,735 bp from pter      End:
36,403,434 bp from pter
Size:
156,700 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CX030_HUMAN, A6PW82 (See protein sequence)
Recommended Name: Putative uncharacterized protein CXorf30  
Size: 633 amino acids; 72017 Da
Sequence caution: Sequence=CAO72050.2; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for CXorf30: NX_A6PW82

Explore proteomics data for CXorf30 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6PW82

  • CXorf30 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXorf30 Protein Expression
    REFSEQ proteins: NP_001092313.2  
    ENSEMBL proteins: 
     ENSP00000367922   ENSP00000403069   ENSP00000367926  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A6PW82


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXorf30

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXorf30 (CX030)

    Search CenterWatch for drugs/clinical trials and news about CXorf30 / CX030

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CXorf30 gene: 
    NM_001098843.4  

    Unigene Cluster for CXorf30:

    Chromosome X open reading frame 30
    Hs.632791  [show with all ESTs]
    Unigene Representative Sequence: NM_001098843
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378653 ENST00000446478 ENST00000378657(uc011mkc.2)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXorf30

    3 DOTS entries:

    DT.70101267  DT.75155906  DT.121284418 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXorf30 expression in normal human tissues (normalized intensities)      CXorf30 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAAAAAA
    CXorf30 Expression
    About this image


    CXorf30 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Endothelium (Cardiovascular System)
             blood vessel   

    See CXorf30 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXorf30

    SOURCE GeneReport for Unigene cluster: Hs.632791
        SABiosciences Custom PCR Arrays for CXorf30
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CXorf30 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm87875 predicted gene 8787   --   X (38.37 cM) 79330513 
    chicken
    (Gallus gallus)
    Aves CXORF306
    Uncharacterized protein
    46(a)
    1 ↔ 1
    1(112906641-112985873)
    lizard
    (Anolis carolinensis)
    Reptilia CXORF306
    Uncharacterized protein
    65(a)
    1 ↔ 1
    3(131560407-131567992)


    ENSEMBL Gene Tree for CXorf30 (if available)
    TreeFam Gene Tree for CXorf30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXorf30 gene

    CXorf30 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CXorf30
    PGOHUM00000241230


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2100 SNPs in CXorf30 are shown (see all 2100)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59021261,2
    C--34125293(+) TGTGC-/ATAT  
            
    atata
    1 -- int10--------
    rs1432026251,2
    --36244959(+) TGATTA/GTGTAG 1 -- us2k10--------
    rs1846094141,2
    --36244982(+) AGAGGG/TTTTTA 1 -- us2k10--------
    rs1467757731,2
    C--36245424(+) ATACAA/GATTTC 1 -- us2k10--------
    rs731971911,2
    C--36245431(+) TTTCAA/GATATT 1 -- us2k10--------
    rs1889328381,2
    --36245562(+) GATATA/GTAACA 1 -- us2k10--------
    rs1996304371,2
    --36245627(+) TAGGG-/TAGT  
            
    TAATG
    1 -- us2k10--------
    rs1918133311,2
    --36246130(+) TTATGA/GGAAGT 1 -- us2k10--------
    rs1845561391,2
    --36246288(+) CTAATA/GTTGCA 1 -- us2k10--------
    rs59720311,2
    C,F,A,H--36246532(+) GAGCAC/GACTGT 1 -- us2k19Minor allele frequency- G:0.25NS EA NA WA CSA 561

    HapMap Linkage Disequilibrium report for CXorf30 (36246735 - 36403434 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CXorf30:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740088CNV Deletion23290073
    esv268765CNV Insertion20981092
    nsv470349CNV Gain18288195


    Locus Specific Mutation Databases (LSDB): CXorf30
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    DNA2.0 Custom Variant and Variant Library Synthesis for CXorf30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CXorf30 for disorders           About MalaCards

    CXorf30 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CXorf30

    Export disorders for CXorf30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXorf30 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CXorf30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (2007)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    3. Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 645090 HGNC: 27298 Ensembl:ENSG00000205081 euGenes: HUgn645090 ECgene: CXorf30
    H-InvDB: CXorf30

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXorf30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXorf30 gene:
    Search GeneIP for patents involving CXorf30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    Customized transgenic rodents for:
     Humanization
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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