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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXorf27 Gene

protein-coding   GIFtS: 42
GCID: GC0XP037850

Chromosome X Open Reading Frame 27

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome X Open Reading Frame 271 2
Huntingtin Yeast Partner M2 3
HYPM2 3
HIP172
Huntingtin-Interacting Protein M2

External Ids:    HGNC: 184171   Entrez Gene: 257632   Ensembl: ENSG000001875167   UniProtKB: O754093   

Export aliases for CXorf27 gene to outside databases

Previous GC identifers: GC0XP037606 GC0XP037735 GC0XP035595


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CXorf27 Gene:
This gene encodes a protein shown to interact with huntingtin, which contains an expanded polyglutamine tract in
individuals with Huntington's disease (PMID: 9700202). (provided by RefSeq, Aug 2011)

GeneCards Summary for CXorf27 Gene: 
CXorf27 (chromosome X open reading frame 27) is a protein-coding gene. Diseases associated with CXorf27 include huntington's disease. GO annotations related to this gene include protein heterodimerization activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXorf27 gene promoter:
         NF-YA   Pax-6   NF-YC   CBF-C   NF-YB   CBF-B   CBF-A   CP1C   CP1A   NF-Y   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CXorf27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp21.1

CXorf27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf27 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP037850:  view genomic region     (about GC identifiers)

Start:
37,850,070 bp from pter      End:
37,850,570 bp from pter
Size:
501 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HYPM_HUMAN, O75409 (See protein sequence)
Recommended Name: Huntingtin-interacting protein M  
Size: 117 amino acids; 13442 Da
Subunit: May interact with the N-terminus of HD
Sequence caution: Sequence=AAC26851.1; Type=Erroneous initiation;
Secondary accessions: A1A4D3

Explore the universe of human proteins at neXtProt for CXorf27: NX_O75409

Explore proteomics data for CXorf27 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75409

  • CXorf27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXorf27 Protein Expression
    REFSEQ proteins: NP_036406.1  
    ENSEMBL proteins: 
     ENSP00000339511  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009072 Histone-fold

    Graphical View of Domain Structure for InterPro Entry O75409

    ProtoNet protein and cluster: O75409


    CXorf27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046982protein heterodimerization activity IEA--
         
    CXorf27 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXorf27

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CXorf27 (O754093 ENSP000003395114) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428583, ENSP000003471844I2D: score=2 STRING: ENSP00000347184
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXorf27 (HYPM)

    Search CenterWatch for drugs/clinical trials and news about CXorf27 / HYPM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CXorf27 gene: 
    NM_012274.1  

    Unigene Cluster for CXorf27:

    Chromosome X open reading frame 27
    Hs.122959  [show with all ESTs]
    Unigene Representative Sequence: NM_012274
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000341016(uc004ddt.4)
    miRNA
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    Additional mRNA sequence: 

    AF049615.1 BC104428.1 BC104429.1 BC113024.1 BC113025.1 

    1 DOTS entry:

    DT.75114365 

    9 AceView cDNA sequences:

    AA813313 AF049615 AW291697 BX111086 AA429694 AI656266 AI806113 AA815276 
    AI918856 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXorf27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTAAAAAAA
    CXorf27 Expression
    About this image


    See CXorf27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXorf27

    SOURCE GeneReport for Unigene cluster: Hs.122959
        SABiosciences Custom PCR Arrays for CXorf27
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CXorf27 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700054O13Rik5 RIKEN cDNA 1700054O13 gene   --   X (4.61 cM) 9846928 


    ENSEMBL Gene Tree for CXorf27 (if available)
    TreeFam Gene Tree for CXorf27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/54 SNPs in CXorf27 are shown (see all 54)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815116771,2
    --37764739(+) GGAAAC/GACATA 1 -- us2k10--------
    rs1850118681,2
    C--37764799(+) GAGAAA/GTTTTC 1 -- us2k10--------
    rs59175191,2
    C,F--37765159(+) tgaaaG/Aaagtc 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs734803381,2
    C--37765184(+) AATTTA/GACAGG 1 -- us2k12Minor allele frequency- G:0.33WA CSA 3
    rs1894753981,2
    --37765406(+) TTTGAA/GACTCC 1 -- us2k10--------
    rs1389624801,2
    --37765407(+) TTGAGA/TCTCCT 1 -- us2k10--------
    rs1810691411,2
    --37765573(+) TACACA/TTCTGG 1 -- us2k10--------
    rs1406803101,2
    C--37765655(+) ATCTTA/GTTATT 1 -- us2k10--------
    rs1860003651,2
    C--37765679(+) AGACCA/G/TAGTCC 1 -- us2k10--------
    rs1895419891,2
    C--37765803(+) GCGCCC/TGCCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CXorf27 (37850070 - 37850570 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CXorf27:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv518029CNV Gain19592680
    esv2752323CNV Gain17911159
    nsv519012CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): CXorf27
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CXorf27:    About MalaCards
    huntington's disease    


    CXorf27 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CXorf27

    Export disorders for CXorf27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXorf27 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CXorf27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Huntingtin interacts with a family of WW domain proteins. (PubMed id 9700202)1, 2, 3 Faber P.W....MacDonald M.E. (1998)
    2. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
    3. Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)4 Kerns S.L....Rosenstein B.S. (2010)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17362836)4 Schymick J.C....Traynor B.J. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25763 HGNC: 18417 AceView: CXorf27 Ensembl:ENSG00000187516 euGenes: HUgn25763
    ECgene: CXorf27 H-InvDB: CXorf27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXorf27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXorf27 gene:
    Search GeneIP for patents involving CXorf27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Proteins for CXorf27
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf27
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CXorf27
     Browse SwitchGear Promoter luciferase reporter plasmids for CXorf27
     Search ThermoFisher Antibodies for CXorf27
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXorf27
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CXorf27
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXorf27
    Customized:
     lentivirus for stable overexpression of CXorf27
     lentivirus expression plasmids for stable overexpression of CXorf27
     adenovirus for overexpression of CXorf27
     Search LSBio for Antibodies for CXorf27
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
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     Tissue-specific gene expresssion
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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