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Aliases for CXorf23 Gene

Aliases for CXorf23 Gene

  • Chromosome X Open Reading Frame 23 2 3 5

External Ids for CXorf23 Gene

Previous GeneCards Identifiers for CXorf23 Gene

  • GC0XM019295
  • GC0XM019694
  • GC0XM019840
  • GC0XM017676

Summaries for CXorf23 Gene

GeneCards Summary for CXorf23 Gene

CXorf23 (Chromosome X Open Reading Frame 23) is a Protein Coding gene. An important paralog of this gene is BCLAF1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf23 Gene

Genomics for CXorf23 Gene

Regulatory Elements for CXorf23 Gene

Enhancers for CXorf23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG019989 1.1 Ensembl ENCODE 29.3 +0.2 234 2.4 RB1 ZNF76 SIN3A RAD21 GLIS2 ELK1 ZNF143 RCOR1 SP3 ZBTB11 CXorf23 MAP7D2 LOC729609
GH0XG020066 1.1 Ensembl ENCODE 27.7 -76.8 -76809 1.8 ZBTB40 RAD21 ZNF143 FOS ZNF654 CEBPB ZEB2 REST MAFF SMARCA4 CXorf23 MAP7D2 SH3KBP1 MIR23C
GH0XG019846 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +143.7 143698 2.3 ATF1 CBX5 ZSCAN5C FOS IKZF2 ZNF680 CBFB JUNB IKZF1 MYC CXorf23 SH3KBP1 GC0XP019714
GH0XG020139 1 ENCODE 25.1 -150.8 -150765 4.1 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 CXorf23 EIF1AX EIF1AX-AS1
GH0XG019771 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +216.4 216365 7.1 HDGF PKNOX1 ZSCAN4 YBX1 EBF1 RELA ZFHX2 GATA2 EED SCRT2 SH3KBP1 CXorf23 MAP7D2 RPS6KA3 GC0XP019714
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXorf23 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXorf23 Gene

Chromosome:
X
Start:
19,912,860 bp from pter
End:
19,990,934 bp from pter
Size:
78,075 bases
Orientation:
Minus strand

Genomic View for CXorf23 Gene

Genes around CXorf23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf23 Gene

Proteins for CXorf23 Gene

  • Protein details for CXorf23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2AJT9-CX023_HUMAN
    Recommended name:
    Uncharacterized protein CXorf23
    Protein Accession:
    A2AJT9
    Secondary Accessions:
    • A1A4E8
    • Q5VSM7
    • Q5VSN1
    • Q6ZS60
    • Q8N1W7

    Protein attributes for CXorf23 Gene

    Size:
    711 amino acids
    Molecular mass:
    83871 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04399.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC87094.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71712.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CXorf23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf23 Gene

Post-translational modifications for CXorf23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CXorf23 Gene

Domains & Families for CXorf23 Gene

Protein Domains for CXorf23 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXorf23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf23: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CXorf23 Gene

Function for CXorf23 Gene

genes like me logo Genes that share phenotypes with CXorf23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf23 Gene

Localization for CXorf23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXorf23 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf23 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CXorf23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CXorf23: view

Pathways & Interactions for CXorf23 Gene

SuperPathways for CXorf23 Gene

No Data Available

Interacting Proteins for CXorf23 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369009%0d%0a9606.ENSP00000354346%0d%0a
Selected Interacting proteins: ENSP00000369009 A2AJT9-CX023_HUMAN for CXorf23 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CXorf23 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf23 Gene

Drugs & Compounds for CXorf23 Gene

No Compound Related Data Available

Transcripts for CXorf23 Gene

Unigene Clusters for CXorf23 Gene

Chromosome X open reading frame 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:

Relevant External Links for CXorf23 Gene

GeneLoc Exon Structure for
CXorf23
ECgene alternative splicing isoforms for
CXorf23

Expression for CXorf23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CXorf23 Gene

This gene is overexpressed in Heart (46.1), Peripheral blood mononuclear cells (13.0), and Prostate (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXorf23 Gene



Protein tissue co-expression partners for CXorf23 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXorf23 Gene:

CXorf23

SOURCE GeneReport for Unigene cluster for CXorf23 Gene:

Hs.28896

Evidence on tissue expression from TISSUES for CXorf23 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with CXorf23: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf23 Gene

Orthologs for CXorf23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXorf23 35
  • 100 (a)
OneToOne
CXHXorf23 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia CXHXorf23 34
  • 87.27 (n)
CXorf23 35
  • 70 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXHXorf23 34
  • 84.09 (n)
CXORF23 35
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562161 34
  • 79.81 (n)
mouse
(Mus musculus)
Mammalia A830080D01Rik 34 16 35
  • 78.53 (n)
oppossum
(Monodelphis domestica)
Mammalia CXorf23 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1HXorf23 34
  • 69.24 (n)
CXorf23 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXorf23 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490423 34
  • 55.03 (n)
Species where no ortholog for CXorf23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXorf23 Gene

ENSEMBL:
Gene Tree for CXorf23 (if available)
TreeFam:
Gene Tree for CXorf23 (if available)

Paralogs for CXorf23 Gene

Paralogs for CXorf23 Gene

(1) SIMAP similar genes for CXorf23 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CXorf23: view

Variants for CXorf23 Gene

Sequence variations from dbSNP and Humsavar for CXorf23 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000044649 -- 19,966,133(+) GTTGA(C/T)TGGGA nc-transcript-variant, reference, synonymous-codon
rs1000118738 -- 19,970,956(+) AATAC(A/G)AGCAC intron-variant, upstream-variant-2KB
rs1000177973 -- 19,986,665(+) AAACT(A/G)AGAAA intron-variant, downstream-variant-500B
rs1000234218 -- 19,983,582(+) TGGTG(A/G)CATGC intron-variant
rs1000240583 -- 19,959,121(+) ACAGG(A/T)CAAAG intron-variant, reference, stop-lost

Structural Variations from Database of Genomic Variants (DGV) for CXorf23 Gene

Variant ID Type Subtype PubMed ID
nsv1110597 CNV duplication 24896259
nsv1140019 CNV duplication 24896259
nsv1150454 CNV duplication 26484159

Variation tolerance for CXorf23 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXorf23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf23 Gene

Disorders for CXorf23 Gene

Relevant External Links for CXorf23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXorf23

No disorders were found for CXorf23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf23 Gene

Publications for CXorf23 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3 64

Products for CXorf23 Gene

Sources for CXorf23 Gene

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