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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CXorf23 Gene

protein-coding GIFtS: 39
GCID: GC0XM019840

chromosome X open reading frame 23

Search for CXorf23
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome X Open Reading Frame 23¹ ²
Uncharacterized Protein CXorf23²

External Ids:	HGNC: 27413¹	Entrez Gene: 256643²	Ensembl: ENSG00000173681⁷	UniProtKB: A2AJT9³

Export aliases for CXorf23 gene to outside databases

Previous GC identifers: GC0XM019295 GC0XM019694 GC0XM017676

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167197.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CXorf23 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C CHOP-10 POU2F1 POU2F1a POU2F2B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXorf23 promoter sequence

Search SABiosciences Chromatin IP Primers for CXorf23

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf23

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.12 Ensembl cytogenetic band: Xp22.12 HGNC cytogenetic band: Xp22.13

CXorf23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf23 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM019840: view genomic region (about GC identifiers)

Start:	19,930,978 bp from pter	End:	19,988,416 bp from pter
Size:	57,439 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CX023_HUMAN, A2AJT9 (See protein sequence)

Recommended Name: Uncharacterized protein CXorf23

Size: 711 amino acids; 83871 Da

Subcellular location: Mitochondrion (Potential)

Sequence caution: Sequence=BAC04399.1; Type=Erroneous initiation; Sequence=BAC87094.1; Type=Erroneous initiation;

Sequence=CAH71712.2; Type=Erroneous gene model prediction;

Secondary accessions: A1A4E8 Q5VSM7 Q5VSN1 Q6ZS60 Q8N1W7

Alternative splicing: 3 isoforms: A2AJT9-1 A2AJT9-2 A2AJT9-3 (No experimental confirmation available. Ref.2 (BAC04399) sequence is in conflict in positions: 617:S->G, 622:Q->R)

Explore the universe of human proteins at neXtProt for CXorf23: NX_A2AJT9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A2AJT9

CXorf23 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_938020.2

ENSEMBL proteins:

ENSP00000369009 ENSP00000437272 ENSP00000369004 ENSP00000342104 ENSP00000349470

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	Uscn Proteins for CXorf23

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--

CXorf23 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: A2AJT9

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for CXorf23:

Decreased viability with pacli

Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for A830080D01Rik):

normal

CXorf23 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CXorf23

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CXorf23
Search CenterWatch for drugs/clinical trials and news about CXorf23 / CX023

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for CXorf23 gene:

NM_198279.3

Unigene Cluster for CXorf23:

Chromosome X open reading frame 23

Hs.28896 [show with all ESTs]

Unigene Representative Sequence: NM_198279

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379687(uc011mjg.2 uc004czo.3 uc004czp.3) ENST00000472158

ENST00000379682 ENST00000466702 ENST00000471203 ENST00000340625 ENST00000356980

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		hsa-miR-548j hsa-miR-100* hsa-miR-607 hsa-miR-300 hsa-miR-938 hsa-miR-374a hsa-miR-3653 hsa-miR-502-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CXorf23 3' UTR sequence

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Additional cDNA sequence:

AK094661.1 AK127709.1 AL833278.1 BC093092.1 BC126172.1 BC143906.1

9 DOTS entries:

DT.101979609 DT.40110831 DT.107212 DT.40108080 DT.91736229 DT.40117985 DT.100684492 DT.100684486

DT.91689274

24/51 AceView cDNA sequences (see all 51):

AW467196 CA440711 AI920798 BM475195 AW518945 AI857793 AK127709 AW628045

NM_198279 BG698176 AA737054 BC046187 BX090219 AK094661 AW169861 BE880939

AI921632 AI124981 AL079296 BF510921 R68626 BM830288 AW664220 BG254582

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CXorf23 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b
SP1:																	-
SP2:

ECgene alternative splicing isoforms for CXorf23

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CXorf23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGAACTTT

About this image
See CXorf23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXorf23

SOURCE GeneReport for Unigene cluster: Hs.28896

SABiosciences Custom PCR Arrays for CXorf23

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CXorf23 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	A830080D01Rik^{1 , 5}	RIKEN cDNA A830080D01 gene^{1, 5}	78.21(n)¹ 64.78(a)¹		X (73.55 cM)⁵ 382252¹ NM_001033472.2¹ NP_001028644.2¹ 159526688⁵
chicken (Gallus gallus)	Aves	LOC100858121¹	uncharacterized LOC100858121	69.08(n) 56.66(a)		100858121 XM_003640516.1 XP_003640564.1
lizard (Anolis carolinensis)	Reptilia	CXorf23⁶	--	46(a)	1 ↔ 1	3(123782842-123798791)
zebrafish (Danio rerio)	Actinopterygii	zgc:112982⁶	zgc:112982	13(a)	1 ↔ 1	24(24709759-24726449)

ENSEMBL Gene Tree for CXorf23 (if available)
TreeFam Gene Tree for CXorf23 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CXorf23 gene

THRAP3² BCLAF1²

1 SIMAP similar gene for CXorf23 using alignment to 4 protein entries: CX023_HUMAN (see all proteins):

FLJ00047

CXorf23 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12841127^1,2	F,	--	19930733(+)	`acaCCG/ATGCCT`	1	--	ds500¹		2		NA	4
rs191388180^1,2		--	19930738(+)	`GTGCCC/TGGCCA`	1	--	ds500¹		0	--	--	--	--
rs185101533^1,2		--	19930855(+)	`GGGAGA/GAATGG`	1	--	ds500¹		0	--	--	--	--
rs5909340^1,2	C,	--	19931280(+)	`ttcgcA/Ctcccg`	1	--	ut3¹		0	--	--	--	--
rs189504856^1,2		--	19931294(+)	`TTAAGC/TAATTC`	1	--	ut3¹		0	--	--	--	--
rs193220063^1,2		--	19931383(+)	`GATGGA/GGTTTC`	1	--	ut3¹		0	--	--	--	--
rs185258858^1,2		--	19931444(+)	`GCCTCA/GGCCTC`	1	--	ut3¹		0	--	--	--	--
rs190159616^1,2		--	19931558(+)	`TTGAAA/GGGGCT`	1	--	ut3¹		0	--	--	--	--
rs151285618^1,2		--	19931678(+)	`CAGATA/TGCTTG`	1	--	ut3¹		0	--	--	--	--
rs11336313^1,2	C,	--	19931934(+)	`TCTTA-/AGTCTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CXorf23 (19930978 - 19988416 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CXorf23: --
Locus Specific Mutation Databases (LSDB): CXorf23

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CXorf23 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CXorf23)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2, 3} Ota T.... Sugano S. (2004)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
The DNA sequence of the human X chromosome. (PubMed id 15772651)² Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 256643	HGNC: 27413	AceView: CXorf23	Ensembl:ENSG00000173681	euGenes: HUgn256643
ECgene: CXorf23	H-InvDB: CXorf23

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CXorf23	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CXorf23 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CXorf23 gene:
Search GeneIP for patents involving CXorf23

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CXorf23 gene at Home site.

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CXorf23 Gene

chromosome X open reading frame 23

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Export list of displayed genes

CXorf23 Gene

chromosome X open reading frame 23

Aliasesfor CXorf23 gene

Summariesfor CXorf23 gene

Genomic Viewsfor CXorf23 gene

Proteinsfor CXorf23 gene

Protein Domains /Familiesfor CXorf23 gene

Functionfor CXorf23 gene

Pathways & Interactionsfor CXorf23 gene

Drugs & Compoundsfor CXorf23 gene

Transcriptsfor CXorf23 gene

Expression for CXorf23 gene

Orthologsfor CXorf23 gene

Paralogsfor CXorf23 gene

Genomic Variantsfor CXorf23 gene

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Publicationsfor CXorf23 gene

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Genome Databases showing CXorf23 gene

Other Databases showing CXorf23 gene

Specialized Databases showing CXorf23 gene

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Productsfor CXorf23 gene

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Aliases
for CXorf23 gene

Summaries
for CXorf23 gene

Genomic Views
for CXorf23 gene

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for CXorf23 gene

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Families
for CXorf23 gene

Function
for CXorf23 gene

Pathways & Interactions
for CXorf23 gene

Drugs & Compounds
for CXorf23 gene

Transcripts
for CXorf23 gene

Expression
for CXorf23 gene

Orthologs
for CXorf23 gene

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for CXorf23 gene

Genomic Variants
for CXorf23 gene

Disorders / Diseases
for CXorf23 gene

Publications
for CXorf23 gene

Intellectual Property
for CXorf23 gene

Products
for CXorf23 gene