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CXorf23 Gene

protein-coding   GIFtS: 41
GCID: GC0XM019840

Chromosome X Open Reading Frame 23

  Search for CXorf23
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome X Open Reading Frame 231 2
Uncharacterized Protein CXorf232

External Ids:    HGNC: 274131   Entrez Gene: 2566432   Ensembl: ENSG000001736817   UniProtKB: A2AJT93   

Export aliases for CXorf23 gene to outside databases

Previous GC identifers: GC0XM019295 GC0XM019694 GC0XM017676


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CXorf23 Gene:
CXorf23 (chromosome X open reading frame 23) is a protein-coding gene. An important paralog of this gene is THRAP3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXorf23 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   CHOP-10   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXorf23 promoter sequence
   Search Chromatin IP Primers for CXorf23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXorf23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.12   Ensembl cytogenetic band:  Xp22.12   HGNC cytogenetic band: Xp22.13

CXorf23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf23 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM019840:  view genomic region     (about GC identifiers)

Start:
19,930,978 bp from pter      End:
19,988,416 bp from pter
Size:
57,439 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CX023_HUMAN, A2AJT9 (See protein sequence)
Recommended Name: Uncharacterized protein CXorf23  
Size: 711 amino acids; 83871 Da
Sequence caution: Sequence=BAC04399.1; Type=Erroneous initiation; Sequence=BAC87094.1; Type=Erroneous initiation;
Sequence=CAH71712.2; Type=Erroneous gene model prediction;
Secondary accessions: A1A4E8 Q5VSM7 Q5VSN1 Q6ZS60 Q8N1W7
Alternative splicing: 3 isoforms:  A2AJT9-1   A2AJT9-2   A2AJT9-3   (No experimental confirmation available. Ref.2 (BAC04399) sequence is in conflict in positions: 617:S->G, 622:Q->R)

Explore the universe of human proteins at neXtProt for CXorf23: NX_A2AJT9

Explore proteomics data for CXorf23 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CXorf23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_938020.2  
    ENSEMBL proteins: 
     ENSP00000369009   ENSP00000437272   ENSP00000369004   ENSP00000342104   ENSP00000349470  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: A2AJT9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for CXorf23:
     Decreased viability with pacli 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for A830080D01Rik):
     normal 

    Find genes that share phenotypes with CXorf23           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXorf23
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    hsa-miR-548j hsa-miR-100* hsa-miR-607 hsa-miR-300 hsa-miR-938 hsa-miR-374a hsa-miR-3653 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidCXorf23 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CXorf23

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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CXorf23

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CX023_HUMAN, A2AJT9: Mitochondrion (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with CXorf23           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CXorf23
    Interactions:

        Search GeneGlobe Interaction Network for CXorf23

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXorf23 (CX023)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CXorf23 gene: 
    NM_198279.3  

    Unigene Cluster for CXorf23:

    Chromosome X open reading frame 23
    Hs.28896  [show with all ESTs]
    Unigene Representative Sequence: NM_198279
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379687(uc011mjg.2 uc004czo.3 uc004czp.3) ENST00000451208(uc004czn.4)
    ENST00000456553 ENST00000472158 ENST00000379682 ENST00000466702 ENST00000471203
    ENST00000340625 ENST00000356980
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CXorf23 (see all 125):
    hsa-miR-548j hsa-miR-100* hsa-miR-607 hsa-miR-300 hsa-miR-938 hsa-miR-374a hsa-miR-3653 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidCXorf23 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXorf23
      QuantiTect SYBR Green Assays in human, mouse, rat CXorf23
      QuantiFast Probe-based Assays in human, mouse, rat CXorf23

    Additional mRNA sequence: 

    AK094661.1 AK127709.1 AL833278.1 BC093092.1 BC126172.1 BC143906.1 

    9 DOTS entries:

    DT.101979609  DT.40110831  DT.107212  DT.40108080  DT.91736229  DT.40117985  DT.100684492  DT.100684486 
    DT.91689274 

    Selected AceView cDNA sequences (see all 51):

    AA737054 BC046187 BM475195 AW628045 AI920798 CA440711 AW518945 BG698176 
    AW467196 NM_198279 BX090219 AK127709 AI857793 AI921632 BE880939 AI124981 
    BF510921 CD102745 AL079296 AK094661 R68626 AL713433 BM830288 BG254582 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CXorf23    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                  -                           
    SP2:                                                                              


    ECgene alternative splicing isoforms for CXorf23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXorf23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAACTTT
    CXorf23 Expression
    About this image


    CXorf23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    CXorf23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXorf23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.28896
        Custom PCR Arrays for CXorf23
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXorf23 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia A830080D01Rik1 , 5 RIKEN cDNA A830080D01 gene1, 5 78.53(n)1
    65.17(a)1
      X (73.55 cM)5
    3822521  NM_001033472.21  NP_001028644.21 
     1595266885 
    chicken
    (Gallus gallus)
    Aves C1HXorf231 chromosome 1 open reading frame, human CXorf23 69.24(n)
    57.12(a)
      100858121  XM_003640516.2  XP_003640564.2 
    lizard
    (Anolis carolinensis)
    Reptilia CXorf236
    chromosome X open reading frame 23
    44(a)
    1 ↔ 1
    3(123780063-123816610)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004904231 chromosome unknown open reading frame, human CXorf23 55.03(n)
    38.04(a)
      100490423  XM_002935187.2  XP_002935233.2 


    ENSEMBL Gene Tree for CXorf23 (if available)
    TreeFam Gene Tree for CXorf23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CXorf23 gene
    THRAP32  BCLAF12  
    1 SIMAP similar gene for CXorf23 using alignment to 4 protein entries:     CX023_HUMAN (see all proteins):
    FLJ00047

    Find genes that share paralogs with CXorf23           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXorf23 (see all 689)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs128411271,2
    F--19844490(+) acaCCG/ATGCCT 1 -- ds50012Minor allele frequency- A:0.50NA 4
    rs1913881801,2
    --19844495(+) GTGCCC/TGGCCA 1 -- ds50010--------
    rs1851015331,2
    --19844612(+) GGGAGA/GAATGG 1 -- ds50010--------
    rs59093401,2
    C--19845037(+) ttcgcA/Ctcccg 1 -- ut310--------
    rs1895048561,2
    --19845051(+) TTAAGC/TAATTC 1 -- ut310--------
    rs1932200631,2
    --19845140(+) GATGGA/GGTTTC 1 -- ut310--------
    rs1852588581,2
    --19845201(+) GCCTCA/GGCCTC 1 -- ut310--------
    rs1901596161,2
    --19845315(+) TTGAAA/GGGGCT 1 -- ut310--------
    rs1512856181,2
    C--19845435(+) CAGATA/TGCTTG 1 -- ut310--------
    rs2003082821,2
    --19845693(+) CTTAA-/GTCTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CXorf23 (19930978 - 19988416 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CXorf23: --
    Locus Specific Mutation Databases (LSDB): CXorf23

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXorf23
    DNA2.0 Custom Variant and Variant Library Synthesis for CXorf23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXorf23 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CXorf23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 256643 HGNC: 27413 AceView: CXorf23 Ensembl:ENSG00000173681 euGenes: HUgn256643
    ECgene: CXorf23 H-InvDB: CXorf23

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXorf23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXorf23 gene:
    Search GeneIP for patents involving CXorf23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Search Addgene for plasmids for CXorf23
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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