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CXorf22 Gene

protein-coding   GIFtS: 36
GCID: GC0XP035937

Chromosome X Open Reading Frame 22

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome X Open Reading Frame 221 2
Uncharacterized Protein CXorf222

External Ids:    HGNC: 285461   Entrez Gene: 1700632   Ensembl: ENSG000001651647   UniProtKB: Q6ZTR53   

Export aliases for CXorf22 gene to outside databases

Previous GC identifers: GC0XP035300 GC0XP035697 GC0XP035847 GC0XP033678


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CXorf22 Gene:
CXorf22 (chromosome X open reading frame 22) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CXorf22 gene promoter:
         AREB6   GATA-3   FOXO4   NCX/Ncx   STAT5A   GATA-2   GATA-1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXorf22 promoter sequence
   Search Chromatin IP Primers for CXorf22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXorf22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp21.1   HGNC cytogenetic band: Xp21.1

CXorf22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf22 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP035937:  view genomic region     (about GC identifiers)

Start:
35,937,851 bp from pter      End:
36,008,269 bp from pter
Size:
70,419 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CX022_HUMAN, Q6ZTR5 (See protein sequence)
Recommended Name: Uncharacterized protein CXorf22  
Size: 976 amino acids; 110411 Da
Secondary accessions: Q5JRM8 Q8N6X8
Alternative splicing: 2 isoforms:  Q6ZTR5-1   Q6ZTR5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CXorf22: NX_Q6ZTR5

Explore proteomics data for CXorf22 at MOPED


See CXorf22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689845.2  
ENSEMBL proteins: 
 ENSP00000297866   ENSP00000433564  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q6ZTR5


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CXorf22

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion2
cytosol1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CXorf22
Interactions:

    Search GeneGlobe Interaction Network for CXorf22

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CXorf22 (CX022)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CXorf22 gene: 
NM_152632.3  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000297866(uc004ddj.3 uc010ngv.3) ENST00000493930
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5 AceView cDNA sequences:

NM_152632 BC027936 AK126295 BI766354 CD686506 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CXorf22    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1:                                                                                                            
SP2:                                                                                      -                     


ECgene alternative splicing isoforms for CXorf22

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXorf22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CATATGTATA
CXorf22 Expression
About this image


CXorf22 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Testis (Reproductive System)
         Spermatid Seminiferous Tubules
 
 Gonad
         Spermatid Seminiferous Tubules
CXorf22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CXorf22 Protein Expression
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CXorf22 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gm71731 , 5 predicted gene 71731, 5 77.19(n)1
67.06(a)1
  X (38.38 cM)5
6361041  NM_001099307.11  NP_001092777.11 
 794825685 
chicken
(Gallus gallus)
Aves C1HXORF591 chromosome 1 open reading frame, human CXORF59 58.36(n)
44.13(a)
  418583  XM_416785.4  XP_416785.4 
lizard
(Anolis carolinensis)
Reptilia CXorf226
chromosome X open reading frame 22
47(a)
1 ↔ 1
3(131953552-131992699)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004964171 uncharacterized LOC100496417 56.24(n)
45.13(a)
  100496417  XM_002933814.2  XP_002933860.2 


ENSEMBL Gene Tree for CXorf22 (if available)
TreeFam Gene Tree for CXorf22 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CXorf22 (see all 1235)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1895370411,2
--35849760(+) CCCATA/GCATAT 1 -- us2k10--------
rs1431233481,2
C--35849841(+) GAAAAC/TAGAAA 1 -- us2k10--------
rs734669111,2
C--35849935(+) AATATG/ATAAGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs1474977931,2
--35850009(+) GTAGAA/GCTATG 1 -- us2k10--------
rs1815953351,2
--35850012(+) GAGCTA/GTGTGA 1 -- us2k10--------
rs1863609251,2
--35850062(+) AAACAA/TAATTG 1 -- us2k10--------
rs1908848681,2
--35850143(+) AGAGTA/GAAAAA 1 -- us2k10--------
rs1400811951,2
--35850248(+) TATGAA/GCTATT 1 -- us2k10--------
rs1429433441,2
--35850286(+) GCTTAC/GGGGCT 1 -- us2k10--------
rs45593911,2
C,H--35850294(+) GCTCAG/CGAACA 1 -- us2k14Minor allele frequency- C:0.00NS EA 420

HapMap Linkage Disequilibrium report for CXorf22 (35937851 - 36008269 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for CXorf22:    About this table    
Variant IDTypeSubtypePubMed ID
esv1035775CNV Insertion17803354
nsv516150CNV Gain19592680
nsv470349CNV Gain18288195

Locus Specific Mutation Databases (LSDB): CXorf22

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CXorf22 gene integrated from 10 sources:
(articles sorted by number of sources associating them with CXorf22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 170063 HGNC: 28546 AceView: CXorf22 Ensembl:ENSG00000165164 euGenes: HUgn170063
ECgene: CXorf22 H-InvDB: CXorf22

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CXorf22 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CXorf22 gene:
Search GeneIP for patents involving CXorf22

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from genOway)
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