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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXorf22 Gene

protein-coding   GIFtS: 39
GCID: GC0XP035937

chromosome X open reading frame 22
  Search for CXorf22
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CXorf22    

Aliases
for CXorf22 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome X Open Reading Frame 221 2
MGC348311
Uncharacterized Protein CXorf222

External Ids:    HGNC: 285461   Entrez Gene: 1700632   Ensembl: ENSG000001651647   UniProtKB: Q6ZTR53   

Export aliases for CXorf22 gene to outside databases

Previous GC identifers: GC0XP035300 GC0XP035697 GC0XP035847 GC0XP033678


Summaries
for CXorf22 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for CXorf22 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXorf22 gene promoter:
         AREB6   GATA-3   FOXO4   NCX/Ncx   STAT5A   GATA-2   GATA-1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXorf22 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXorf22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXorf22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp21.1   HGNC cytogenetic band: Xp21.1

CXorf22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf22 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP035937:  view genomic region     (about GC identifiers)

Start:
 35,937,851 bp from pter      End:
 36,008,269 bp from pter
Size:
 70,419 bases      Orientation:
 plus strand

Proteins
for CXorf22 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CX022_HUMAN, Q6ZTR5 (See protein sequence)
Recommended Name: Uncharacterized protein CXorf22  
Size: 976 amino acids; 110411 Da
Secondary accessions: Q5JRM8 Q8N6X8
Alternative splicing: 2 isoforms:  Q6ZTR5-1   Q6ZTR5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CXorf22: NX_Q6ZTR5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZTR5

    • CXorf22 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689845.2  
    ENSEMBL proteins: 
     ENSP00000297866   ENSP00000433564  

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    Protein Domains /
    Families
    for CXorf22 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZTR5


    Function
    for CXorf22 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for CXorf22 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXorf22

    Drugs & Compounds
    for CXorf22 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXorf22
    Search CenterWatch for drugs/clinical trials and news about CXorf22 / CX022 

    Transcripts
    for CXorf22 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for CXorf22 gene: 
    NM_152632.3  

    Unigene Cluster for CXorf22:

    Chromosome X open reading frame 22
    Hs.742234  [show with all ESTs]
    Unigene Representative Sequence: NM_152632
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297866(uc004ddj.3 uc010ngv.3) ENST00000493930

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    Inhib. RNA
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    Additional cDNA sequence: AK126295.1 

    2 DOTS entries:

    DT.101975904  DT.100008120 

    5 AceView cDNA sequences:

    BC027936 NM_152632 BI766354 AK126295 CD686506 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CXorf22    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
    SP1:                                                                                                            
    SP2:                                                                                      -                     


    ECgene alternative splicing isoforms for CXorf22

    Expression
    for CXorf22 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXorf22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATATGTATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CXorf22 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CXorf22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXorf22

    SOURCE GeneReport for Unigene cluster: Hs.742234
        SABiosciences Custom PCR Arrays for CXorf22
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf22

    Orthologs
    for CXorf22 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CXorf22 gene from 2/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves C1HXorf221 chromosome 1 open reading frame, human CXorf59 58.5(n)
    44.24(a)    		   418583  XM_416785.3  XP_416785.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CXorf226
    		 --
    		 46(a)
    		 1 ↔ 1
    		 3(131953552-131992699)


    ENSEMBL Gene Tree for CXorf22 (if available)
    TreeFam Gene Tree for CXorf22 (if available) 

    Paralogs
    for CXorf22 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CXorf22 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1031 NCBI SNPs in CXorf22 are shown (see all 1031)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1895370411,2
    		--35935868(+) CCCATA/GCATAT 1 -- us2k10--------
    rs1431233481,2
    		--35935949(+) GAAAAC/TAGAAA 1 -- us2k10--------
    rs734669111,2
    		C,--35936043(+) AATATG/ATAAGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1474977931,2
    		--35936117(+) GTAGAA/GCTATG 1 -- us2k10--------
    rs1815953351,2
    		--35936120(+) GAGCTA/GTGTGA 1 -- us2k10--------
    rs1863609251,2
    		--35936170(+) AAACAA/TAATTG 1 -- us2k10--------
    rs1908848681,2
    		--35936251(+) AGAGTA/GAAAAA 1 -- us2k10--------
    rs1400811951,2
    		--35936356(+) TATGAA/GCTATT 1 -- us2k10--------
    rs1429433441,2
    		--35936394(+) GCTTAC/GGGGCT 1 -- us2k10--------
    rs45593911,2
    		C,H--35936402(+) GCTCAG/CGAACA 1 -- us2k14Minor allele frequency- C:0.00NS EA 420

    HapMap Linkage Disequilibrium report for CXorf22 (35937851 - 36008269 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CXorf22
         1 CNV: 52987
    Locus Specific Mutation Databases (LSDB): CXorf22

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    Disorders / Diseases
    for CXorf22 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for CXorf22 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXorf22 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CXorf22)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for CXorf22 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CXorf22 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 170063 HGNC: 28546 AceView: CXorf22 Ensembl:ENSG00000165164 euGenes: HUgn170063
    ECgene: CXorf22 H-InvDB: CXorf22

    Other Databases showing CXorf22 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXorf22 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXorf22 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CXorf22 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CXorf22 gene:
    Search GeneIP for patents involving CXorf22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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