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Aliases for CXorf21 Gene

Aliases for CXorf21 Gene

  • Chromosome X Open Reading Frame 21 2 3 5
  • Uncharacterized Protein CXorf21 3
  • 5430427O19Rik 3

External Ids for CXorf21 Gene

Previous GeneCards Identifiers for CXorf21 Gene

  • GC0XM029939
  • GC0XM030336
  • GC0XM030486
  • GC0XM028314

Summaries for CXorf21 Gene

GeneCards Summary for CXorf21 Gene

CXorf21 (Chromosome X Open Reading Frame 21) is a Protein Coding gene.

Additional gene information for CXorf21 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf21 Gene

Genomics for CXorf21 Gene

Regulatory Elements for CXorf21 Gene

Enhancers for CXorf21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH030651 1.7 FANTOM5 ENCODE dbSUPER 22.5 -79.8 -79826 12 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS PAF1 SP3 GK CXorf21 GK-AS1 GC0XM030662
GH0XH030620 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.9 -43.3 -43285 1 ATF1 JUN BACH1 ZNF175 ATF2 FOSL1 MEF2D ZNF589 JUND ATF3 GK CXorf21 GC0XP030617 FTLP2
GH0XH030612 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.3 -35.2 -35213 2 FOXA2 JUND NFIA CEBPA CEBPB HNF4A ZNF384 RAD21 GK CXorf21 CKS1BP6 PIR31090
GH0XH030625 1.5 FANTOM5 ENCODE dbSUPER 19.6 -49.6 -49629 3 ELF3 TBP FOXA2 ATF1 MLX ARID4B DMAP1 RARA ATF7 CREM GK CXorf21 FTLP2 GC0XP030617
GH0XH030572 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.1 +2.3 2280 6 PKNOX1 TBL1XR1 BMI1 BATF RFX5 ZNF207 ATF7 ETV6 RUNX3 CREM GK CXorf21 GC0XM030519
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXorf21 on UCSC Golden Path with GeneCards custom track

Promoters for CXorf21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CXorf21 Gene

30,558,824 bp from pter
30,577,916 bp from pter
19,093 bases
Minus strand

Genomic View for CXorf21 Gene

Genes around CXorf21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf21 Gene

Proteins for CXorf21 Gene

  • Protein details for CXorf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein CXorf21
    Protein Accession:

    Protein attributes for CXorf21 Gene

    301 amino acids
    Molecular mass:
    33894 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXorf21 Gene

Post-translational modifications for CXorf21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXorf21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXorf21 Gene

Domains & Families for CXorf21 Gene

Gene Families for CXorf21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXorf21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf21: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CXorf21 Gene

Function for CXorf21 Gene

Phenotypes From GWAS Catalog for CXorf21 Gene

genes like me logo Genes that share phenotypes with CXorf21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CXorf21
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf21 Gene

Localization for CXorf21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf21 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CXorf21 Gene

Pathways & Interactions for CXorf21 Gene

SuperPathways for CXorf21 Gene

No Data Available

Interacting Proteins for CXorf21 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000368245 Q9HAI6-CX021_HUMAN for CXorf21 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CXorf21 Gene


No data available for Pathways by source and SIGNOR curated interactions for CXorf21 Gene

Drugs & Compounds for CXorf21 Gene

No Compound Related Data Available

Transcripts for CXorf21 Gene

mRNA/cDNA for CXorf21 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXorf21 Gene

Chromosome X open reading frame 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CXorf21
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf21 Gene

No ASD Table

Relevant External Links for CXorf21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXorf21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf21 Gene

mRNA differential expression in normal tissues according to GTEx for CXorf21 Gene

This gene is overexpressed in Whole Blood (x15.9).

NURSA nuclear receptor signaling pathways regulating expression of CXorf21 Gene:


SOURCE GeneReport for Unigene cluster for CXorf21 Gene:

genes like me logo Genes that share expression patterns with CXorf21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf21 Gene

Orthologs for CXorf21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXorf21 34
  • 100 (a)
CXHXorf21 33
  • 99.56 (n)
(Canis familiaris)
Mammalia CXHXorf21 33
  • 88.96 (n)
CXorf21 34
  • 88 (a)
(Bos Taurus)
Mammalia C9HXorf21 34 33
  • 86.47 (n)
(Rattus norvegicus)
Mammalia RGD1565785 33
  • 85.46 (n)
(Mus musculus)
Mammalia 5430427O19Rik 34 16 33
  • 85.35 (n)
(Monodelphis domestica)
Mammalia CXorf21 34
  • 68 (a)
(Gallus gallus)
Aves C1HXorf21 33
  • 63.99 (n)
CXorf21 34
  • 54 (a)
(Anolis carolinensis)
Reptilia CXorf21 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490948 33
  • 55.82 (n)
(Danio rerio)
Actinopterygii LOC796876 33
  • 50.16 (n)
Species where no ortholog for CXorf21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf21 Gene

Gene Tree for CXorf21 (if available)
Gene Tree for CXorf21 (if available)

Paralogs for CXorf21 Gene Pseudogenes for CXorf21 Gene

genes like me logo Genes that share paralogs with CXorf21: view

No data available for Paralogs for CXorf21 Gene

Variants for CXorf21 Gene

Sequence variations from dbSNP and Humsavar for CXorf21 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000193956 -- 30,575,779(+) GACGA(G/T)CTGAT intron-variant
rs1000196401 -- 30,569,382(+) TGACC(A/G)AAATG intron-variant
rs1000207756 -- 30,570,254(+) CACAC(-/ACACACAT)ATATA intron-variant
rs1000543521 -- 30,572,968(+) GATAC(A/G)CATCA intron-variant
rs1000894437 -- 30,559,136(+) CTCAT(A/T)TGACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CXorf21 Gene

Variant ID Type Subtype PubMed ID
nsv510532 OTHER sequence alteration 20534489

Variation tolerance for CXorf21 Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXorf21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf21 Gene

Disorders for CXorf21 Gene

Relevant External Links for CXorf21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CXorf21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf21 Gene

Publications for CXorf21 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for CXorf21 Gene

Sources for CXorf21 Gene

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