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CXorf21 Gene

protein-coding   GIFtS: 37
GCID: GC0XM030486

Chromosome X Open Reading Frame 21

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome X Open Reading Frame 211 2
5430427O19Rik2
Uncharacterized Protein CXorf212

External Ids:    HGNC: 256671   Entrez Gene: 802312   Ensembl: ENSG000001202807   UniProtKB: Q9HAI63   

Export aliases for CXorf21 gene to outside databases

Previous GC identifers: GC0XM029939 GC0XM030336 GC0XM028314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CXorf21 Gene:
CXorf21 (chromosome X open reading frame 21) is a protein-coding gene. Diseases associated with CXorf21 include klinefelter's syndrome, and gonadal dysgenesis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXorf21 gene promoter:
         STAT5B   STAT1   AML1a   STAT4   STAT1beta   STAT5A   STAT1alpha   c-Rel   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXorf21 promoter sequence
   Search Chromatin IP Primers for CXorf21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXorf21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.2   Ensembl cytogenetic band:  Xp21.2   HGNC cytogenetic band: Xp21.3

CXorf21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXorf21 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM030486:  view genomic region     (about GC identifiers)

Start:
30,576,941 bp from pter      End:
30,596,033 bp from pter
Size:
19,093 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CX021_HUMAN, Q9HAI6 (See protein sequence)
Recommended Name: Uncharacterized protein CXorf21  
Size: 301 amino acids; 33894 Da

Explore the universe of human proteins at neXtProt for CXorf21: NX_Q9HAI6

Explore proteomics data for CXorf21 at MOPED


See CXorf21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_079435.1  
ENSEMBL proteins: 
 ENSP00000368245  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR027869 DUF4569

Graphical View of Domain Structure for InterPro Entry Q9HAI6

ProtoNet protein and cluster: Q9HAI6

1 Blocks protein domain: IPB002198 Short-chain dehydrogenase/reductase SDR


CXorf21 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidCXorf21 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus2
cytosol1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CXorf21
Interactions:

    Search GeneGlobe Interaction Network for CXorf21

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CXorf21 (CX021)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CXorf21 gene: 
NM_025159.2  

Unigene Cluster for CXorf21:

Chromosome X open reading frame 21
Hs.665009  [show with all ESTs]
Unigene Representative Sequence: NM_025159
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000378962(uc004dcg.2)
miRNA
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hsa-miR-203 hsa-miR-205 hsa-miR-4268 hsa-miR-1251 hsa-miR-877* hsa-miR-4330 hsa-miR-617 hsa-miR-1976
SwitchGear 3'UTR luciferase reporter plasmidCXorf21 3' UTR sequence
Inhib. RNA
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat CXorf21

Additional mRNA sequence: 

AK021639.1 BC020611.1 

3 DOTS entries:

DT.437127  DT.95178516  DT.92419140 

17 AceView cDNA sequences:

AA815029 BX281759 AK021639 BG258487 BG389404 AV711988 BG256925 AA741263 
NM_025159 CD640479 AU118416 BG256514 BC020611 BG105992 BG622270 AU144986 
CD706434 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXorf21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CXorf21 Expression
About this image

CXorf21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CXorf21 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.665009
    Custom PCR Arrays for CXorf21
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXorf21

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CXorf21 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 5430427O19Rik1 , 5 RIKEN cDNA 5430427O19 gene1, 5 85.35(n)1
84.23(a)1
  X (39.39 cM)5
713981  NM_001163539.11  NP_001157011.11 
 858703545 
chicken
(Gallus gallus)
Aves C1HXorf211 chromosome 1 open reading frame, human CXorf21 63.99(n)
56.29(a)
  100857674  XM_003640512.2  XP_003640560.1 
lizard
(Anolis carolinensis)
Reptilia CXorf216
chromosome X open reading frame 21
52(a)
1 ↔ 1
3(129190722-129191597)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004909481 uncharacterized LOC100490948 55.82(n)
48.1(a)
  100490948  XM_002937665.2  XP_002937711.2 
zebrafish
(Danio rerio)
Actinopterygii LOC7968761 uncharacterized LOC796876 50.16(n)
45.24(a)
  796876  XM_001334236.3  XP_001334272.1 


ENSEMBL Gene Tree for CXorf21 (if available)
TreeFam Gene Tree for CXorf21 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CXorf21 gene

CXorf21 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CXorf21
PGOHUM00000241873


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CXorf21 (see all 314)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs70663921,2
C,A--30490874(+) cacccA/Gcctcg 1 -- ds50010--------
rs78922311,2
C,F,A--30490916(+) gccacC/Tgcacc 1 -- ds50011Minor allele frequency- T:0.50WA 2
rs1855520641,2
--30491048(+) GATGTA/CGGAGA 1 -- ds50010--------
rs1895519281,2
--30491558(+) CCGGTC/TTCGAA 1 -- ut310--------
rs1820135991,2
--30491572(+) CTGACA/GTCAGG 1 -- ut310--------
rs1145387911,2
C--30491576(+) CGTCAA/GGTAAT 1 -- ut310--------
rs25328731,2
C,A,H--30491600(+) CCTCCC/GAAATG 1 -- ut31 ese38Minor allele frequency- G:0.00WA NA CSA 14
rs1497733061,2
C--30491613(+) GGGATG/TACAGG 1 -- ut310--------
rs27104021,2
C,F,A,H--30491639(-) AAGGTA/GGCCGG 1 -- ut31 ese322Minor allele frequency- G:0.08NS EA WA NA CSA 1993
rs1485449581,2
--30491763(+) ACACCA/TCTCTT 1 -- ut310--------

HapMap Linkage Disequilibrium report for CXorf21 (30576941 - 30596033 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CXorf21:    About this table    
Variant IDTypeSubtypePubMed ID
nsv510532CNV Loss20534489

Locus Specific Mutation Databases (LSDB): CXorf21

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CXorf21
DNA2.0 Custom Variant and Variant Library Synthesis for CXorf21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for CXorf21:    
About MalaCards
klinefelter's syndrome    gonadal dysgenesis


CXorf21 for disorders           About GeneDecksing


Export disorders for CXorf21 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CXorf21 gene integrated from 10 sources:
(articles sorted by number of sources associating them with CXorf21)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 80231 HGNC: 25667 AceView: CXorf21 Ensembl:ENSG00000120280 euGenes: HUgn80231
ECgene: CXorf21 H-InvDB: CXorf21

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CXorf21 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CXorf21 gene:
Search GeneIP for patents involving CXorf21

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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