Aliases for CXXC5 Gene
External Ids for CXXC5 Gene
Previous GeneCards Identifiers for CXXC5 Gene
GeneCards Summary for CXXC5 Gene
CXXC5 (CXXC Finger Protein 5) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is CXXC4.
UniProtKB/Swiss-Prot for CXXC5 Gene
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).