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Aliases for CXXC5 Gene

Aliases for CXXC5 Gene

  • CXXC Finger Protein 5 2 3
  • Retinoid-Inducible Nuclear Factor 2 3 4
  • Putative NF-Kappa-B-Activating Protein 102 3 4
  • Putative MAPK-Activating Protein PM08 3 4
  • WT1-Induced Inhibitor Of Dishevelled 2 3
  • RINF 3 4
  • CF5 3 4
  • CXXC-Type Zinc Finger Protein 5 3
  • CXXC Finger 5 Protein 3
  • HSPC195 3
  • WID 3

External Ids for CXXC5 Gene

Previous GeneCards Identifiers for CXXC5 Gene

  • GC05P139057
  • GC05P139008
  • GC05P134203
  • GC05P139026

Summaries for CXXC5 Gene

GeneCards Summary for CXXC5 Gene

CXXC5 (CXXC Finger Protein 5) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is CXXC4.

UniProtKB/Swiss-Prot for CXXC5 Gene

  • May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).

Gene Wiki entry for CXXC5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXXC5 Gene

Genomics for CXXC5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CXXC5 Gene

Start:
139,647,299 bp from pter
End:
139,683,882 bp from pter
Size:
36,584 bases
Orientation:
Plus strand

Genomic View for CXXC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXXC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXXC5 Gene

Proteins for CXXC5 Gene

  • Protein details for CXXC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LFL8-CXXC5_HUMAN
    Recommended name:
    CXXC-type zinc finger protein 5
    Protein Accession:
    Q7LFL8
    Secondary Accessions:
    • B3KND0
    • C8CBA8
    • Q8TB79
    • Q9NV51
    • Q9P0S8

    Protein attributes for CXXC5 Gene

    Size:
    322 amino acids
    Molecular mass:
    32977 Da
    Quaternary structure:
    • Interacts with DVL1. Interacts with RBPJ (PubMed:23303788).
    SequenceCaution:
    • Sequence=AAF36115.1; Type=Frameshift; Positions=32, 102, 119, 250, 265; Evidence={ECO:0000305}; Sequence=AAH02490.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH06428.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17439.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH24040.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH41013.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CXXC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXXC5 Gene

Proteomics data for CXXC5 Gene at MOPED

Post-translational modifications for CXXC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CXXC5 (CXXC5)

No data available for DME Specific Peptides for CXXC5 Gene

Domains for CXXC5 Gene

Protein Domains for CXXC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXXC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7LFL8

UniProtKB/Swiss-Prot:

CXXC5_HUMAN :
  • Q7LFL8
Similarity:
  • Contains 1 CXXC-type zinc finger.
genes like me logo Genes that share domains with CXXC5: view

No data available for Gene Families for CXXC5 Gene

Function for CXXC5 Gene

Molecular function for CXXC5 Gene

UniProtKB/Swiss-Prot Function: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).
UniProtKB/Swiss-Prot Induction: By retinoic acid.

Gene Ontology (GO) - Molecular Function for CXXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 23303788
GO:0008134 transcription factor binding IDA 23303788
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CXXC5: view

Animal Model Products

CRISPR Products

miRNA for CXXC5 Gene

miRTarBase miRNAs that target CXXC5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CXXC5 Gene

Localization for CXXC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXXC5 Gene

Nucleus. Cytoplasm. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXXC5 Gene COMPARTMENTS Subcellular localization image for CXXC5 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CXXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus --
GO:0005737 cytoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with CXXC5: view

Pathways for CXXC5 Gene

SuperPathways for CXXC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CXXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 23303788
GO:0007165 signal transduction IMP 12761501
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with CXXC5: view

No data available for Pathways by source for CXXC5 Gene

Transcripts for CXXC5 Gene

Unigene Clusters for CXXC5 Gene

CXXC finger protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXXC5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXXC5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:
SP10: - - - -

Relevant External Links for CXXC5 Gene

GeneLoc Exon Structure for
CXXC5
ECgene alternative splicing isoforms for
CXXC5

Expression for CXXC5 Gene

mRNA expression in normal human tissues for CXXC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CXXC5 Gene

SOURCE GeneReport for Unigene cluster for CXXC5 Gene Hs.744933

genes like me logo Genes that share expressions with CXXC5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CXXC5 Gene

Orthologs for CXXC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXXC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXXC5 35
  • 99.38 (n)
  • 99.69 (a)
CXXC5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXXC5 35
  • 90.64 (n)
  • 92.43 (a)
CXXC5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXXC5 35
  • 91.81 (n)
  • 95.56 (a)
CXXC5 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxxc5 35
  • 88.81 (n)
  • 93.21 (a)
Cxxc5 16
Cxxc5 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CXXC5 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXXC5 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxxc5 35
  • 88.05 (n)
  • 93.21 (a)
chicken
(Gallus gallus)
Aves CXXC5 35
  • 73.31 (n)
  • 80.08 (a)
CXXC5 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXXC5 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cxxc5a 35
  • 65.86 (n)
  • 65.18 (a)
cxxc5a 36
  • 56 (a)
OneToOne
Species with no ortholog for CXXC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXXC5 Gene

ENSEMBL:
Gene Tree for CXXC5 (if available)
TreeFam:
Gene Tree for CXXC5 (if available)

Paralogs for CXXC5 Gene

Paralogs for CXXC5 Gene

genes like me logo Genes that share paralogs with CXXC5: view

Variants for CXXC5 Gene

Sequence variations from dbSNP and Humsavar for CXXC5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs183072 -- 139,674,448(-) AATGC(A/G)CCACT intron-variant, upstream-variant-2KB
rs187167 -- 139,649,415(-) GCGAG(C/T)GGGGT intron-variant
rs356445 -- 139,680,901(-) TCCAC(C/T)GCCAT synonymous-codon, reference
rs356446 -- 139,657,926(-) GGGGG(A/G)TTTGC intron-variant
rs356447 -- 139,653,694(-) GTGAC(C/T)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXXC5 Gene

Variant ID Type Subtype PubMed ID
nsv519808 CNV Loss 19592680
nsv830504 CNV Gain 17160897
nsv882941 CNV Loss 21882294
nsv882942 CNV Loss 21882294
nsv830505 CNV Loss 17160897
nsv462460 CNV Loss 19166990
dgv6341n71 CNV Loss 21882294
nsv882945 CNV Loss 21882294
dgv6342n71 CNV Loss 21882294

Relevant External Links for CXXC5 Gene

HapMap Linkage Disequilibrium report
CXXC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXXC5 Gene

Disorders for CXXC5 Gene

Relevant External Links for CXXC5

Genetic Association Database (GAD)
CXXC5
Human Genome Epidemiology (HuGE) Navigator
CXXC5
genes like me logo Genes that share disorders with CXXC5: view

No data available for UniProtKB/Swiss-Prot for CXXC5 Gene

Publications for CXXC5 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. (PMID: 19182210) Pendino F. … Lillehaug J.R. (Blood 2009) 2 3 4
  3. The CXXC finger 5 protein is required for DNA damage-induced p53 activation. (PMID: 19557330) Zhang M. … Shu H.-B. (Sci. China, Ser. C, Life Sci. 2009) 3 4
  4. Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. (PMID: 19865112) Carbuccia N. … Mozziconacci M.J. (Leukemia 2010) 3 48
  5. A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. (PMID: 20220130) Kim M.S. … Lee S.B. (J. Biol. Chem. 2010) 2 3

Products for CXXC5 Gene

Sources for CXXC5 Gene

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