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Aliases for CXXC5 Gene

Aliases for CXXC5 Gene

  • CXXC Finger Protein 5 2 3 5
  • Retinoid-Inducible Nuclear Factor 2 3 4
  • Putative NF-Kappa-B-Activating Protein 102 3 4
  • Putative MAPK-Activating Protein PM08 3 4
  • WT1-Induced Inhibitor Of Dishevelled 2 3
  • RINF 3 4
  • CF5 3 4
  • CXXC Finger 5 Protein 3
  • HSPC195 3
  • WID 3

External Ids for CXXC5 Gene

Previous GeneCards Identifiers for CXXC5 Gene

  • GC05P139057
  • GC05P139008
  • GC05P134203
  • GC05P139026

Summaries for CXXC5 Gene

Entrez Gene Summary for CXXC5 Gene

  • The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for CXXC5 Gene

CXXC5 (CXXC Finger Protein 5) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and signal transducer activity. An important paralog of this gene is CXXC4.

UniProtKB/Swiss-Prot for CXXC5 Gene

  • May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).

Gene Wiki entry for CXXC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXXC5 Gene

Genomics for CXXC5 Gene

Genomic Location for CXXC5 Gene

Chromosome:
5
Start:
139,647,299 bp from pter
End:
139,683,882 bp from pter
Size:
36,584 bases
Orientation:
Plus strand

Genomic View for CXXC5 Gene

Genes around CXXC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXXC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXXC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXXC5 Gene

Proteins for CXXC5 Gene

  • Protein details for CXXC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LFL8-CXXC5_HUMAN
    Recommended name:
    CXXC-type zinc finger protein 5
    Protein Accession:
    Q7LFL8
    Secondary Accessions:
    • B3KND0
    • C8CBA8
    • Q8TB79
    • Q9NV51
    • Q9P0S8

    Protein attributes for CXXC5 Gene

    Size:
    322 amino acids
    Molecular mass:
    32977 Da
    Quaternary structure:
    • Interacts with DVL1. Interacts with RBPJ (PubMed:23303788).
    SequenceCaution:
    • Sequence=AAF36115.1; Type=Frameshift; Positions=32, 102, 119, 250, 265; Evidence={ECO:0000305}; Sequence=AAH02490.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH06428.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17439.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH24040.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH41013.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CXXC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXXC5 Gene

Proteomics data for CXXC5 Gene at MOPED

Post-translational modifications for CXXC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CXXC5 (CXXC5)

No data available for DME Specific Peptides for CXXC5 Gene

Domains & Families for CXXC5 Gene

Gene Families for CXXC5 Gene

Protein Domains for CXXC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXXC5 Gene

Graphical View of Domain Structure for InterPro Entry

Q7LFL8

UniProtKB/Swiss-Prot:

CXXC5_HUMAN :
  • Contains 1 CXXC-type zinc finger.
Similarity:
  • Contains 1 CXXC-type zinc finger.
genes like me logo Genes that share domains with CXXC5: view

Function for CXXC5 Gene

Molecular function for CXXC5 Gene

UniProtKB/Swiss-Prot Function:
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Gene Ontology (GO) - Molecular Function for CXXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0008134 transcription factor binding IDA 23303788
GO:0043565 sequence-specific DNA binding IDA 23303788
genes like me logo Genes that share ontologies with CXXC5: view
genes like me logo Genes that share phenotypes with CXXC5: view

Animal Models for CXXC5 Gene

MGI Knock Outs for CXXC5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXXC5 Gene

Localization for CXXC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXXC5 Gene

Nucleus. Cytoplasm. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXXC5 Gene COMPARTMENTS Subcellular localization image for CXXC5 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for CXXC5 Gene

Pathways & Interactions for CXXC5 Gene

SuperPathways for CXXC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CXXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IMP 12761501
genes like me logo Genes that share ontologies with CXXC5: view

No data available for Pathways by source and SIGNOR curated interactions for CXXC5 Gene

Drugs & Compounds for CXXC5 Gene

No Compound Related Data Available

Transcripts for CXXC5 Gene

Unigene Clusters for CXXC5 Gene

CXXC finger protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXXC5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:
SP10: - - - -

Relevant External Links for CXXC5 Gene

GeneLoc Exon Structure for
CXXC5
ECgene alternative splicing isoforms for
CXXC5

Expression for CXXC5 Gene

mRNA expression in normal human tissues for CXXC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CXXC5 Gene

This gene is overexpressed in Pancreatic juice (54.7) and Serum (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CXXC5 Gene



SOURCE GeneReport for Unigene cluster for CXXC5 Gene Hs.744933

genes like me logo Genes that share expression patterns with CXXC5: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CXXC5 Gene

Orthologs for CXXC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXXC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CXXC5 35
  • 90.64 (n)
  • 92.43 (a)
CXXC5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXXC5 35
  • 91.81 (n)
  • 95.56 (a)
CXXC5 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxxc5 35
  • 88.81 (n)
  • 93.21 (a)
Cxxc5 16
Cxxc5 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CXXC5 35
  • 99.38 (n)
  • 99.69 (a)
CXXC5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxxc5 35
  • 88.05 (n)
  • 93.21 (a)
oppossum
(Monodelphis domestica)
Mammalia CXXC5 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXXC5 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CXXC5 35
  • 73.31 (n)
  • 80.08 (a)
CXXC5 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXXC5 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cxxc5a 35
  • 65.86 (n)
  • 65.18 (a)
cxxc5a 36
  • 56 (a)
OneToOne
Species with no ortholog for CXXC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXXC5 Gene

ENSEMBL:
Gene Tree for CXXC5 (if available)
TreeFam:
Gene Tree for CXXC5 (if available)

Paralogs for CXXC5 Gene

Paralogs for CXXC5 Gene

genes like me logo Genes that share paralogs with CXXC5: view

Variants for CXXC5 Gene

Sequence variations from dbSNP and Humsavar for CXXC5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs187167 -- 139,649,415(-) GCGAG(C/T)GGGGT intron-variant
rs183072 -- 139,674,448(-) AATGC(A/G)CCACT intron-variant, upstream-variant-2KB
rs650446 -- 139,674,925(+) CATCT(A/T)CTTCC intron-variant, upstream-variant-2KB
rs356445 -- 139,680,901(-) TCCAC(C/T)GCCAT reference, synonymous-codon
rs356446 -- 139,657,926(-) GGGGG(A/G)TTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXXC5 Gene

Variant ID Type Subtype PubMed ID
nsv519808 CNV Loss 19592680
nsv830504 CNV Gain 17160897
nsv882941 CNV Loss 21882294
nsv882942 CNV Loss 21882294
nsv830505 CNV Loss 17160897
nsv462460 CNV Loss 19166990
dgv6341n71 CNV Loss 21882294
nsv882945 CNV Loss 21882294
dgv6342n71 CNV Loss 21882294

Variation tolerance for CXXC5 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXXC5 Gene

HapMap Linkage Disequilibrium report
CXXC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXXC5 Gene

Disorders for CXXC5 Gene

Relevant External Links for CXXC5

Genetic Association Database (GAD)
CXXC5
Human Genome Epidemiology (HuGE) Navigator
CXXC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXXC5

No disorders were found for CXXC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXXC5 Gene

Publications for CXXC5 Gene

  1. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. (PMID: 19182210) Pendino F. … Lillehaug J.R. (Blood 2009) 2 3 4 67
  2. A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. (PMID: 20220130) Kim M.S. … Lee S.B. (J. Biol. Chem. 2010) 2 3
  3. CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. (PMID: 19001364) Andersson T. … Hermanson O. (J. Biol. Chem. 2009) 2 3
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  5. Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia. (PMID: 25805812) KA1hnl A. … Grimwade D. (Blood 2015) 3

Products for CXXC5 Gene

Sources for CXXC5 Gene

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