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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXXC5 Gene

protein-coding   GIFtS: 50
GCID: GC05P139008

CXXC Finger Protein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CXXC Finger Protein 51 2     CF52 3
Retinoid-Inducible Nuclear Factor1 2 3     RINF2 3
WT1-Induced Inhibitor Of Dishevelled1 2     WID2
Putative MAPK-Activating Protein PM082 3     CXXC Finger 5 Protein2
Putative NF-Kappa-B-Activating Protein 1022 3     CXXC-Type Zinc Finger Protein 52

External Ids:    HGNC: 269431   Entrez Gene: 515232   Ensembl: ENSG000001716047   OMIM: 6127525   UniProtKB: Q7LFL83   

Export aliases for CXXC5 gene to outside databases

Previous GC identifers: GC05P139057 GC05P134203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CXXC5 Gene: 
CXXC5 (CXXC finger protein 5) is a protein-coding gene. Diseases associated with CXXC5 include dyslexia, and wilms tumor. GO annotations related to this gene include DNA binding and signal transducer activity. An important paralog of this gene is CXXC4.

UniProtKB/Swiss-Prot: CXXC5_HUMAN, Q7LFL8
Function: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of
BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for
DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis

Gene Wiki entry for CXXC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXXC5 gene promoter:
         NCX/Ncx   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   GATA-1   CREB   PPAR-alpha   HEN1   AREB6   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXXC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXXC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXXC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.3

CXXC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXXC5 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P139008:  view genomic region     (about GC identifiers)

Start:
139,026,884 bp from pter      End:
139,063,467 bp from pter
Size:
36,584 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXXC5_HUMAN, Q7LFL8 (See protein sequence)
Recommended Name: CXXC-type zinc finger protein 5  
Size: 322 amino acids; 32977 Da
Subunit: Interacts with DVL1 (By similarity)
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Colocalizes with DVL1 in large bodies localized
just outside the nuclear membrane (By similarity)
Sequence caution: Sequence=AAF36115.1; Type=Frameshift; Positions=32, 102, 119, 250, 265; Sequence=AAH02490.3;
Type=Erroneous initiation; Sequence=AAH06428.1; Type=Erroneous initiation; Sequence=AAH17439.2; Type=Erroneous
initiation; Sequence=AAH24040.2; Type=Erroneous initiation; Sequence=AAH41013.2; Type=Erroneous initiation;
Secondary accessions: B3KND0 C8CBA8 Q8TB79 Q9NV51 Q9P0S8
Alternative splicing: 2 isoforms:  Q7LFL8-1   Q7LFL8-2   

Explore the universe of human proteins at neXtProt for CXXC5: NX_Q7LFL8

Explore proteomics data for CXXC5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7LFL8

  • CXXC5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXXC5 Protein Expression
    REFSEQ proteins: NP_057547.5  
    ENSEMBL proteins: 
     ENSP00000427127   ENSP00000422883   ENSP00000302543   ENSP00000427253   ENSP00000425203  
     ENSP00000426124   ENSP00000430522   ENSP00000427379   ENSP00000423365   ENSP00000427440  
     ENSP00000424219   ENSP00000421057   ENSP00000430949   ENSP00000421866  

    Human Recombinant Protein Products for CXXC5: 
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    Novus Biologicals CXXC5 Proteins
    Novus Biologicals CXXC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    CXXC5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002857 Znf_CXXC

    Graphical View of Domain Structure for InterPro Entry Q7LFL8

    ProtoNet protein and cluster: Q7LFL8

    UniProtKB/Swiss-Prot: CXXC5_HUMAN, Q7LFL8
    Similarity: Contains 1 CXXC-type zinc finger


    CXXC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXXC5_HUMAN, Q7LFL8
    Function: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of
    BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for
    DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis
    Induction: By retinoic acid

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004871signal transducer activity IMP12761501
    GO:0008270zinc ion binding IEA--
         
    CXXC5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CXXC5 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXXC5 
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    miRNA
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    hsa-miR-92a hsa-miR-218-1* hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-182* hsa-miR-659 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmidCXXC5 3' UTR sequence
    Inhib. RNA
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXXC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/8 Interacting proteins for CXXC5 (Q7LFL82, 3 ENSP000003025434) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-61702 I2D: score=2 STRING: ENSP00000332973
    SMAD5Q997172, 3MINT-61823 I2D: score=2 
    SMAD7O151052, 3MINT-61811 I2D: score=2 
    SKILP127572, 3, ENSP000002591194MINT-61639 I2D: score=2 STRING: ENSP00000259119
    SMAD9O151982, 3, ENSP000003691544MINT-62067 I2D: score=2 STRING: ENSP00000369154
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IMP12761501
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IMP12761501

    CXXC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXXC5

    Search CenterWatch for drugs/clinical trials and news about CXXC5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CXXC5 gene: 
    NM_016463.7  

    Unigene Cluster for CXXC5:

    CXXC finger protein 5
    Hs.744933  [show with all ESTs]
    Unigene Representative Sequence: BC006428
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502295 ENST00000504944 ENST00000302517(uc010jfg.1) ENST00000507139
    ENST00000504844 ENST00000502336 ENST00000520967 ENST00000511048(uc003let.2)
    ENST00000512816 ENST00000509238 ENST00000502716 ENST00000503511 ENST00000511457
    ENST00000511591 ENST00000515038 ENST00000505812
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CXXC5 (see all 9):
    hsa-miR-92a hsa-miR-218-1* hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-182* hsa-miR-659 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmidCXXC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CXXC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXXC5
    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CXXC5 
    Primer
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    OriGene qPCR primer pairs and template standards for CXXC5
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXXC5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXXC5

    Additional mRNA sequence: 

    AB097005.1 AB097032.1 AF151029.1 AK001782.1 AK024338.1 AK314420.1 BC002490.2 BC006428.1 
    BC017439.1 BC024040.1 BC041013.1 BC050046.1 GQ379202.1 

    18 DOTS entries:

    DT.91823968  DT.95322683  DT.455254  DT.100819835  DT.120799032  DT.100819843  DT.100819841  DT.120799053 
    DT.120799051  DT.87078288  DT.95183288  DT.120799037  DT.87000729  DT.100839266  DT.120799034  DT.120799069 
    DT.95322682  DT.100819836 

    24/469 AceView cDNA sequences (see all 469):

    CR614582 BG014722 AK024338 AA970565 BU163820 BC017439 BC006428 CA309239 
    BM717856 AA341443 BM797754 BC024040 BQ130634 AW273768 H23848 AA463784 
    AW117276 AA978020 BC050046 C03401 BC002490 AI421144 AI160437 BI765525 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CXXC5 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b
    SP1:                    -     -     -     -     -                 -     -     -     -                     
    SP2:              -     -     -     -     -     -                                                         
    SP3:                                      -                                                               
    SP4:              -     -     -     -     -                                                               
    SP5:                    -     -     -     -                                                               


    ECgene alternative splicing isoforms for CXXC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXXC5 expression in normal human tissues (normalized intensities)      CXXC5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTGTCAC
    CXXC5 Expression
    About this image


    CXXC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             CyT49

    See CXXC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXXC5

    SOURCE GeneReport for Unigene cluster: Hs.744933
        SABiosciences Custom PCR Arrays for CXXC5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CXXC5 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxxc51 , 5 CXXC finger 51, 5 91.64(n)1
    96.19(a)1
      18 (19.26 cM)5
    673931  NM_133687.21  NP_598448.11 
     358298185 
    chicken
    (Gallus gallus)
    Aves CXXC51 CXXC finger protein 5 73.41(n)
    80.16(a)
      416138  XM_414471.3  XP_414471.1 
    lizard
    (Anolis carolinensis)
    Reptilia CXXC56
    Uncharacterized protein
    68(a)
    1 ↔ 1
    4(78998808-79017253)
    zebrafish
    (Danio rerio)
    Actinopterygii cxxc51 CXXC finger 5 64.44(n)
    63.94(a)
      557911  XM_681066.4  XP_686158.4 


    ENSEMBL Gene Tree for CXXC5 (if available)
    TreeFam Gene Tree for CXXC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXXC5 gene
    CXXC42  
    1 SIMAP similar gene for CXXC5 using alignment to 12 protein entries:     CXXC5_HUMAN (see all proteins):
    CXXC4

    CXXC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/575 SNPs in CXXC5 are shown (see all 575)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924163481,2
    C--139026377(+) CAAGGA/GAGCCA 1 -- us2k10--------
    rs1425921891,2
    --139026429(+) CGGAAA/GGAACT 1 -- us2k10--------
    rs1845093411,2
    C--139026509(+) AGAGAA/GGCAAC 1 -- us2k10--------
    rs126540141,2
    C,H--139026616(+) CACCAG/ACTGCT 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1873270541,2
    --139026698(+) GAGAGA/GAAGCA 1 -- us2k10--------
    rs2001866191,2
    --139026971(+) CCACT-/TTGGGAT
    TATATGCAG
    TTGGG
    1 -- us2k10--------
    rs1917104491,2
    --139026992(+) TTGGGA/CTTATA 1 -- us2k10--------
    rs1845524881,2
    --139027053(+) GCAGGA/GTTAAT 1 -- us2k10--------
    rs1467825961,2
    --139027214(+) TGTTTA/CGGGTT 1 -- us2k10--------
    rs346449901,2
    C--139027637(+) GTCCTT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for CXXC5 (139026884 - 139063467 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CXXC5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv882945CNV Loss21882294
    dgv6342n71CNV Loss21882294
    nsv519808CNV Loss19592680
    nsv830505CNV Loss17160897
    nsv882942CNV Loss21882294
    dgv6341n71CNV Loss21882294
    nsv882941CNV Loss21882294
    nsv462460CNV Loss19166990
    nsv830504CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612752    OMIM disorders: --

    6 diseases for CXXC5:    About MalaCards
    dyslexia    wilms tumor    acute myeloid leukemia    myeloid leukemia
    leukemia    breast cancer


    CXXC5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CXXC5
    Human Genome Epidemiology (HuGE) Navigator: CXXC5 (2 documents)

    Export disorders for CXXC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXXC5 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with CXXC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. (PubMed id 19182210)1, 2, 3 Pendino F....Lillehaug J.R. (2009)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    3. A novel Wilms tumor 1 (WT1) target gene negatively re gulates the WNT signaling pathway. (PubMed id 20220130)1, 3 Kim M.S....Lee S.B. (2010)
    4. CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. (PubMed id 19001364)1, 3 Andersson T....Hermanson O. (2009)
    5. The CXXC finger 5 protein is required for DNA damage-induced p53 activation. (PubMed id 19557330)1, 2 ZHANG M....SHU H. (2009)
    6. Mutual exclusion of ASXL1 and NPM1 mutations in a ser ies of acute myeloid leukemias. (PubMed id 19865112)1, 4 Carbuccia N....Mozziconacci M.J. (2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (2003)
    9. Downregulation but lack of promoter hypermethylation o r somatic mutations of the potential tumor suppressor CXXC5 in MDS and AML with deletion 5q. (PubMed id 23190153)1 Treppendahl M.B....Gronbaek K. (2013)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51523 HGNC: 26943 AceView: CXXC5 Ensembl:ENSG00000171604 euGenes: HUgn51523
    ECgene: CXXC5 H-InvDB: CXXC5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXXC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXXC5 gene:
    Search GeneIP for patents involving CXXC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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