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CXXC5 Gene

protein-coding   GIFtS: 48
GCID: GC05P139026

CXXC Finger Protein 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CXXC Finger Protein 51 2     CF52 3
Retinoid-Inducible Nuclear Factor1 2 3     RINF2 3
WT1-Induced Inhibitor Of Dishevelled1 2     WID2
Putative MAPK-Activating Protein PM082 3     CXXC Finger 5 Protein2
Putative NF-Kappa-B-Activating Protein 1022 3     CXXC-Type Zinc Finger Protein 52

External Ids:    HGNC: 269431   Entrez Gene: 515232   Ensembl: ENSG000001716047   OMIM: 6127525   UniProtKB: Q7LFL83   

Export aliases for CXXC5 gene to outside databases

Previous GC identifers: GC05P139057 GC05P139008 GC05P134203


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CXXC5 Gene:
CXXC5 (CXXC finger protein 5) is a protein-coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is CXXC4.

UniProtKB/Swiss-Prot: CXXC5_HUMAN, Q7LFL8
Function: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of
BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for
DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis

Gene Wiki entry for CXXC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CXXC5 gene promoter:
         NCX/Ncx   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   GATA-1   CREB   PPAR-alpha   HEN1   AREB6   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXXC5 promoter sequence
   Search Chromatin IP Primers for CXXC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXXC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.3

CXXC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXXC5 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P139026:  view genomic region     (about GC identifiers)

Start:
139,026,884 bp from pter      End:
139,063,467 bp from pter
Size:
36,584 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CXXC5_HUMAN, Q7LFL8 (See protein sequence)
Recommended Name: CXXC-type zinc finger protein 5  
Size: 322 amino acids; 32977 Da
Subunit: Interacts with DVL1 (By similarity)
Sequence caution: Sequence=AAF36115.1; Type=Frameshift; Positions=32, 102, 119, 250, 265; Sequence=AAH02490.3;
Type=Erroneous initiation; Sequence=AAH06428.1; Type=Erroneous initiation; Sequence=AAH17439.2; Type=Erroneous
initiation; Sequence=AAH24040.2; Type=Erroneous initiation; Sequence=AAH41013.2; Type=Erroneous initiation;
Secondary accessions: B3KND0 C8CBA8 Q8TB79 Q9NV51 Q9P0S8
Alternative splicing: 2 isoforms:  Q7LFL8-1   Q7LFL8-2   

Explore the universe of human proteins at neXtProt for CXXC5: NX_Q7LFL8

Explore proteomics data for CXXC5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CXXC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057547.5  
    ENSEMBL proteins: 
     ENSP00000427127   ENSP00000422883   ENSP00000302543   ENSP00000427253   ENSP00000425203  
     ENSP00000426124   ENSP00000430522   ENSP00000427379   ENSP00000423365   ENSP00000427440  
     ENSP00000424219   ENSP00000421057   ENSP00000430949   ENSP00000421866  

    CXXC5 Human Recombinant Protein Products:

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    Novus Biologicals CXXC5 Proteins
    Novus Biologicals CXXC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CXXC5 

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    Browse Enzo Life Sciences for kits & assays
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    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CXXC5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002857 Znf_CXXC

    Graphical View of Domain Structure for InterPro Entry Q7LFL8

    ProtoNet protein and cluster: Q7LFL8

    UniProtKB/Swiss-Prot: CXXC5_HUMAN, Q7LFL8
    Similarity: Contains 1 CXXC-type zinc finger


    Find genes that share domains with CXXC5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXXC5_HUMAN, Q7LFL8
    Function: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of
    BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for
    DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis
    Induction: By retinoic acid

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004871signal transducer activity IMP12761501
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CXXC5           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXXC5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXXC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXXC5

    miRNA
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    miRTarBase miRNAs that target CXXC5:
    hsa-mir-9-5p (MIRT021344), hsa-mir-324-3p (MIRT043013)

    Block miRNA regulation of human, mouse, rat CXXC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CXXC5 (see all 9):
    hsa-miR-92a hsa-miR-218-1* hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-182* hsa-miR-659 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmidCXXC5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CXXC5

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXXC5 (NM_016463)
    Sino Biological Human cDNA Clone for CXXC5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC5

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXXC5_HUMAN, Q7LFL8: Nucleus. Cytoplasm (By similarity). Note=Colocalizes with DVL1 in large bodies localized
    just outside the nuclear membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with CXXC5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CXXC5
    Interactions:

        Search GeneGlobe Interaction Network for CXXC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CXXC5 (Q7LFL82, 3 ENSP000003025434) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-61702 I2D: score=2 STRING: ENSP00000332973
    SMAD5Q997172, 3MINT-61823 I2D: score=2 
    SMAD7O151052, 3MINT-61811 I2D: score=2 
    SKILP127572, 3, ENSP000002591194MINT-61639 I2D: score=2 STRING: ENSP00000259119
    SMAD9O151982, 3, ENSP000003691544MINT-62067 I2D: score=2 STRING: ENSP00000369154
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IMP12761501
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501

    Find genes that share ontologies with CXXC5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXXC5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CXXC5 gene: 
    NM_016463.7  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502295 ENST00000504944 ENST00000302517(uc010jfg.1) ENST00000507139
    ENST00000504844 ENST00000502336 ENST00000520967 ENST00000511048(uc003let.2)
    ENST00000512816 ENST00000509238 ENST00000502716 ENST00000503511 ENST00000511457
    ENST00000511591 ENST00000515038 ENST00000505812
    miRNA
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    Block miRNA regulation of human, mouse, rat CXXC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CXXC5 (see all 9):
    hsa-miR-92a hsa-miR-218-1* hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-182* hsa-miR-659 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmidCXXC5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CXXC5
    Predesigned siRNA for gene silencing in human, mouse, rat CXXC5
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    GenScript: all cDNA clones in your preferred vector: CXXC5 (NM_016463)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXXC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC5
    Primer
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    OriGene qPCR primer pairs and template standards for CXXC5
    OriGene qSTAR qPCR primer pairs in human, mouse for CXXC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXXC5
      QuantiTect SYBR Green Assays in human, mouse, rat CXXC5
      QuantiFast Probe-based Assays in human, mouse, rat CXXC5

    Selected AceView cDNA sequences (see all 469):

    CB242885 BE276606 AA804787 BI838475 AI130933 CA436338 AA769542 BM826699 
    T84321 BF593774 BM680755 BM543418 CR611313 BU163820 BQ716221 AI580364 
    BM717856 BU181878 AA887599 BE676573 BF346203 BM702802 BC002490 CA841886 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CXXC5 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b
    SP1:                    -     -     -     -     -                 -     -     -     -                     
    SP2:              -     -     -     -     -     -                                                         
    SP3:                                      -                                                               
    SP4:              -     -     -     -     -                                                               
    SP5:                    -     -     -     -                                                               


    ECgene alternative splicing isoforms for CXXC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXXC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTGTCAC
    CXXC5 Expression
    About this image


    CXXC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    CXXC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXXC5 Protein Expression
        Custom PCR Arrays for CXXC5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXXC5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxxc51 , 5 CXXC finger 51, 5 88.81(n)1
    93.21(a)1
      18 (19.26 cM)5
    673931  NM_133687.21  NP_598448.11 
     358298185 
    chicken
    (Gallus gallus)
    Aves CXXC51 CXXC finger protein 5 73.31(n)
    80.08(a)
      416138  XM_414471.4  XP_414471.1 
    lizard
    (Anolis carolinensis)
    Reptilia CXXC56
    CXXC finger protein 5
    67(a)
    1 ↔ 1
    4(78998808-79017253)
    zebrafish
    (Danio rerio)
    Actinopterygii cxxc5a1 CXXC finger 5a 65.86(n)
    65.18(a)
      557911  XM_005161382.1  XP_005161439.1 


    ENSEMBL Gene Tree for CXXC5 (if available)
    TreeFam Gene Tree for CXXC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CXXC5 gene
    CXXC42  
    1 SIMAP similar gene for CXXC5 using alignment to 12 protein entries:     CXXC5_HUMAN (see all proteins):
    CXXC4

    Find genes that share paralogs with CXXC5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXXC5 (see all 575)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924163481,2
    C--139026377(+) CAAGGA/GAGCCA 1 -- us2k10--------
    rs1425921891,2
    --139026429(+) CGGAAA/GGAACT 1 -- us2k10--------
    rs1845093411,2
    C--139026509(+) AGAGAA/GGCAAC 1 -- us2k10--------
    rs126540141,2
    C,H--139026616(+) CACCAG/ACTGCT 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1873270541,2
    --139026698(+) GAGAGA/GAAGCA 1 -- us2k10--------
    rs2001866191,2
    --139026971(+) CCACT-/TTGGGAT
    TATATGCAG
    TTGGG
    1 -- us2k10--------
    rs1917104491,2
    --139026992(+) TTGGGA/CTTATA 1 -- us2k10--------
    rs1845524881,2
    --139027053(+) GCAGGA/GTTAAT 1 -- us2k10--------
    rs1467825961,2
    --139027214(+) TGTTTA/CGGGTT 1 -- us2k10--------
    rs346449901,2
    C--139027637(+) GTCCTT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for CXXC5 (139026884 - 139063467 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CXXC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882945CNV Loss21882294
    dgv6342n71CNV Loss21882294
    nsv519808CNV Loss19592680
    nsv830505CNV Loss17160897
    nsv882942CNV Loss21882294
    dgv6341n71CNV Loss21882294
    nsv882941CNV Loss21882294
    nsv462460CNV Loss19166990
    nsv830504CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CXXC5
    DNA2.0 Custom Variant and Variant Library Synthesis for CXXC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612752    OMIM disorders: --


    Find genes that share disorders with CXXC5           About GenesLikeMe

    Genetic Association Database (GAD): CXXC5
    Human Genome Epidemiology (HuGE) Navigator: CXXC5 (2 documents)

    Export disorders for CXXC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXXC5 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CXXC5)
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    1. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. (PubMed id 19182210)1, 2, 3 Pendino F.... Lillehaug J.R. (Blood 2009)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    3. Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. (PubMed id 19865112)1, 4 Carbuccia N....Mozziconacci M.J. (Leukemia 2010)
    4. A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. (PubMed id 20220130)1, 3 Kim M.S....Lee S.B. (J. Biol. Chem. 2010)
    5. The CXXC finger 5 protein is required for DNA damage-induced p53 activation. (PubMed id 19557330)1, 2 Zhang M.... Shu H.-B. (Sci. China, Ser. C, Life Sci. 2009)
    6. CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. (PubMed id 19001364)1, 3 Andersson T....Hermanson O. (J. Biol. Chem. 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    9. Downregulation but lack of promoter hypermethylation or somatic mutations of the potential tumor suppressor CXXC5 in MDS and AML with deletion 5q. (PubMed id 23190153)1 Treppendahl M.B....nbaek K. (Eur. J. Haematol. 2013)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51523 HGNC: 26943 AceView: CXXC5 Ensembl:ENSG00000171604 euGenes: HUgn51523
    ECgene: CXXC5 H-InvDB: CXXC5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXXC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXXC5 gene:
    Search GeneIP for patents involving CXXC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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