Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CXXC4 Gene

protein-coding   GIFtS: 50
GCID: GC04M105389

CXXC Finger Protein 4

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CXXC Finger Protein 41 2
IDAX2 3 5
Dvl-Binding Protein IDAX (Inhibition Of The Dvl And Axin Complex)1 2
Inhibition Of The Dvl And Axin Complex Protein2 3
CXXC Finger 42
CXXC-Type Zinc Finger Protein 42

External Ids:    HGNC: 245931   Entrez Gene: 803192   Ensembl: ENSG000001687727   OMIM: 6116455   UniProtKB: Q9H2H03   

Export aliases for CXXC4 gene to outside databases

Previous GC identifers: GC04M105853 GC04M105747 GC04M105609 GC04M101128


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CXXC4 Gene:
CXXC4 (CXXC finger protein 4) is a protein-coding gene. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is CXXC5.

UniProtKB/Swiss-Prot: CXXC4_HUMAN, Q9H2H0
Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXXC4 gene promoter:
         NF-1   NF-1/L   Sox5   FOXF2   HFH-1   FOXD3   HNF-3beta   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXXC4 promoter sequence
   Search Chromatin IP Primers for CXXC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXXC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22-q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q22-q24

CXXC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXXC4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M105389:  view genomic region     (about GC identifiers)

Start:
105,389,469 bp from pter      End:
105,416,058 bp from pter
Size:
26,590 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CXXC4

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CXXC4_HUMAN, Q9H2H0 (See protein sequence)
Recommended Name: CXXC-type zinc finger protein 4  
Size: 198 amino acids; 20978 Da
Subunit: Interacts with the PDZ domain of DVL1 (By similarity)

Explore the universe of human proteins at neXtProt for CXXC4: NX_Q9H2H0

Explore proteomics data for CXXC4 at MOPED


See CXXC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_079488.2  
ENSEMBL proteins: 
 ENSP00000378248   ENSP00000412267  

CXXC4 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for CXXC4
OriGene Protein Over-expression Lysate for CXXC4
OriGene Custom MassSpec
OriGene Custom Protein Services for CXXC4
GenScript Custom Purified and Recombinant Proteins Services for CXXC4
Novus Biologicals CXXC4 Proteins
Novus Biologicals CXXC4 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CXXC4

 
Search eBioscience for Proteins for CXXC4 

 
antibodies-online proteins for CXXC4 (5 products) 

 
antibodies-online peptides for CXXC4

CXXC4 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for CXXC4
OriGene Custom Antibody Services for CXXC4
Novus Biologicals CXXC4 Antibodies
Search for Antibodies for CXXC4 at Abcam
Cloud-Clone Corp. Antibodies for CXXC4
ThermoFisher Antibody for CXXC4
antibodies-online antibodies for CXXC4 (23 products) 

CXXC4 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CXXC4
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CXXC4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CXXC4
Cloud-Clone Corp. CLIAs for CXXC4
Search eBioscience for ELISAs for CXXC4 
antibodies-online kits for CXXC4 (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
1 InterPro protein domain:
 IPR002857 Znf_CXXC

Graphical View of Domain Structure for InterPro Entry Q9H2H0

ProtoNet protein and cluster: Q9H2H0

UniProtKB/Swiss-Prot: CXXC4_HUMAN, Q9H2H0
Similarity: Contains 1 CXXC-type zinc finger


Find genes that share domains with CXXC4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CXXC4_HUMAN, Q9H2H0
Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0008270zinc ion binding IEA--
GO:0030165PDZ domain binding IPI11113207
     
Find genes that share ontologies with CXXC4           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for CXXC4:
 Cells with protrusions  Synthetic lethal with Ras 

     1 MGI phenotypic allele for Cxxc4 (no phenotypes)

Find genes that share phenotypes with CXXC4           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Cxxc4tm1Lex for CXXC4

   genOway: Develop your customized and physiologically relevant rodent model for CXXC4

miRNA
Products:
    
miRTarBase miRNAs that target CXXC4:
hsa-mir-30b-3p (MIRT038653)

Block miRNA regulation of human, mouse, rat CXXC4 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate CXXC4:
hsa-miR-3662 hsa-miR-3647-3p hsa-miR-1284
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CXXC4
Predesigned siRNA for gene silencing in human, mouse, rat CXXC4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CXXC4

Clone
Products:
     
OriGene clones in human, mouse for CXXC4 (see all 7)
OriGene ORF clones in mouse, rat for CXXC4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXXC4 (NM_025212)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXXC4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC4

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CXXC4
Browse ESI BIO Cell Lines and PureStem Progenitors for CXXC4 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
CXXC4_HUMAN, Q9H2H0: Cytoplasm (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
extracellular1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA11113207
GO:0016023cytoplasmic membrane-bounded vesicle ----
GO:0031410cytoplasmic vesicle IDA11113207

Find genes that share ontologies with CXXC4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for CXXC4 About    
See pathways by source

SuperPathContained pathways About
1Wnt signaling pathway (KEGG)
Wnt signaling pathway0.40
Wnt Signaling Pathway NetPath0.37


Find genes that share SuperPaths with CXXC4           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for CXXC4
    Wnt Signaling Pathway NetPath


1 Kegg Pathway  (Kegg details for CXXC4):
    Wnt signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Array including CXXC4: 
          WNT Signaling Pathway in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for CXXC4

2 Interacting proteins for CXXC4 (Q9H2H03) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DVL1O146403I2D: score=2 
CTNNB1P352223I2D: score=1 
About this table

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007352zygotic specification of dorsal/ventral axis ISS--
GO:0016055Wnt signaling pathway IEA--
GO:0030178negative regulation of Wnt signaling pathway IDA11113207

Find genes that share ontologies with CXXC4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CXXC4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for CXXC4 gene: 
NM_025212.2  

Unigene Cluster for CXXC4:

CXXC finger protein 4
Hs.12248  [show with all ESTs]
Unigene Representative Sequence: NM_025212
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000394767(uc003hxg.3) ENST00000466963(uc010ilo.3) ENST00000515509
ENST00000426831
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CXXC4 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate CXXC4:
hsa-miR-3662 hsa-miR-3647-3p hsa-miR-1284
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CXXC4
Predesigned siRNA for gene silencing in human, mouse, rat CXXC4
Clone
Products:
     
OriGene clones in human, mouse for CXXC4 (see all 7)
OriGene ORF clones in mouse, rat for CXXC4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXXC4 (NM_025212)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXXC4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC4
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CXXC4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXXC4
  QuantiTect SYBR Green Assays in human, mouse, rat CXXC4
  QuantiFast Probe-based Assays in human, mouse, rat CXXC4

Additional mRNA sequence: 

AF272159.1 AK093871.1 AK125395.1 AK127778.1 AK311455.1 BC119751.1 BC119752.1 CR627201.1 

5 DOTS entries:

DT.91908259  DT.40207358  DT.91728597  DT.100646718  DT.403965 

Selected AceView cDNA sequences (see all 78):

R14709 CB269607 BU787845 AK127778 CB070044 F05234 AI359718 AA769966 
AK125395 BG188622 AW028123 BG428495 BU787568 Z41890 Z38252 NM_025212 
F01387 AI377558 F10382 CA435921 AA708035 AL711856 C15297 AF272159 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

CXXC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACAAAACTG
CXXC4 Expression
About this image


CXXC4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Pancreas (Endocrine System)    fully expand to see all 4 entries
         Endocrine Progenitor Cells Ventral Pancreatic Bud
 
 Limb (Muscoskeletal System)    fully expand to see all 4 entries
         Pelvic Girdle
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Bone (Muscoskeletal System)
         Pelvic Girdle
 
 Neural Tube (Nervous System)
         Floor plate-like cells
CXXC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CXXC4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.12248
    Pathway & Disease-focused RT2 Profiler PCR Array including CXXC4: 
          WNT Signaling Pathway in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CXXC4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXXC4
QuantiTect SYBR Green Assays in human, mouse, rat CXXC4
QuantiFast Probe-based Assays in human, mouse, rat CXXC4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for CXXC4 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cxxc41 , 5 CXXC finger 41, 5 91.44(n)1
91.26(a)1
  3 (62.12 cM)5
3194781  NM_001004367.41  NP_001004367.21 
 1342364915 
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.126792 Transcribed sequence with strong similarity to protein more 93.7(n)    BX707307.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1000067541 CXXC-type zinc finger protein 4-like 80.82(n)
83.81(a)
  100006754  XM_001345382.2  XP_001345418.2 


ENSEMBL Gene Tree for CXXC4 (if available)
TreeFam Gene Tree for CXXC4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for CXXC4 gene
CXXC52  
3 SIMAP similar genes for CXXC4 using alignment to 2 protein entries:     CXXC4_HUMAN (see all proteins):
TET3    CXXC5    TET1

Find genes that share paralogs with CXXC4           About GenesLikeMe


1 Pseudogenes.org Pseudogene for CXXC4
PGOHUM00000240687


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for CXXC4 (see all 441)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2008942221,2
C--105388986(+) CATCT-/AGGAGTA 1 -- ds50010--------
rs578113931,2
C--105389092(+) GTAAG-/AAAAAA 1 -- ds50010--------
rs789123191,2
C--105389169(+) ATTCAG/ATTCTT 1 -- ds50014Minor allele frequency- A:0.20CSA WA NA EA 360
rs599441481,2
C--105389286(+) AAAAA-/ATCCCT 1 -- ds50010--------
rs1144068321,2
C,F--105389413(+) ATATGC/TTCATT 1 -- ds50011Minor allele frequency- T:0.02NA 120
rs1466230571,2
--105389470(+) TTTTGA/GGTACT 1 -- ut310--------
rs586128731,2
C--105389550(+) TTTTTT/-ACAGT 1 -- ut311Minor allele frequency- -:0.00NA 2
rs1414252731,2
--105389599(+) TTTCTC/TTAATA 1 -- ut310--------
rs1828527311,2
--105389747(+) GGCCCA/GTGTTC 1 -- ut310--------
rs1880127051,2
--105389773(+) TGCAAC/TTGTGA 1 -- ut310--------

HapMap Linkage Disequilibrium report for CXXC4 (105389469 - 105416058 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CXXC4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv470062CNV Loss18288195

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CXXC4
DNA2.0 Custom Variant and Variant Library Synthesis for CXXC4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 611645    OMIM disorders: --


Find genes that share disorders with CXXC4           About GenesLikeMe

Genetic Association Database (GAD): CXXC4
Human Genome Epidemiology (HuGE) Navigator: CXXC4 (2 documents)

Export disorders for CXXC4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for CXXC4 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with CXXC4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (PubMed id 11113207)1, 2, 3, 9 Hino S.... Kikuchi A. (Mol. Cell. Biol. 2001)
  2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
  3. Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. (PubMed id 18931698)1, 9 Kojima T....Uchida K. (Oncogene 2009)
  4. Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. (PubMed id 23563267)1 Ko M....Rao A. (Nature 2013)
  5. Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4. (PubMed id 23949225)1 Lu H....Jin H. (amp 2013)
  6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
  7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  8. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)1 Teixeira F.R.... Gomes M.D. (Proteomics 2010)
  9. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
  10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 80319 HGNC: 24593 AceView: CXXC4 Ensembl:ENSG00000168772 euGenes: HUgn80319
ECgene: CXXC4 Kegg: 80319 H-InvDB: CXXC4

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for CXXC4 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CXXC4 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for CXXC4 gene:
Search GeneIP for patents involving CXXC4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for CXXC4   OriGene RNAi products in human, mouse, rat for CXXC4  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CXXC4  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for CXXC4  
 OriGene qSTAR qPCR primer pairs in human, mouse for CXXC4   OriGene Purified Protein for CXXC4  
 OriGene ORF clones in mouse, rat for CXXC4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CXXC4   OriGene Custom Protein Services for CXXC4  

 
 
 Block miRNA regulation of human, mouse, rat CXXC4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CXXC4
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXXC4 Predesigned siRNA for gene silencing in human, mouse, rat CXXC4
 QuantiFast Probe-based Assays in human, mouse, rat CXXC4 QuantiTect SYBR Green Assays in human, mouse, rat CXXC4
 PCR Arrays including human, mouse, rat CXXC4 Search Chromatin IP Primers for CXXC4
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXXC4  Search GeneGlobe Interaction Network for CXXC4
 Regulatory tfbs in CXXC4 promoter
 GenScript Custom Purified and Recombinant Proteins Services for CXXC4 GenScript cDNA clones with any tag delivered in your preferred vector for CXXC4
 GenScript Custom Assay Services for CXXC4 GenScript Custom overexpressing Cell Line Services for CXXC4
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for CXXC4
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 CXXC4 antibodies
 CXXC4 proteins
 CXXC4 lysates
 Search for Antibodies for CXXC4 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for CXXC4
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for CXXC4
 Antibodies for CXXC4
 ELISAs for CXXC4
 CLIAs for CXXC4



 Browse ESI BIO Cell Lines and PureStem Progenitors for CXXC4
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC4
 Browse SwitchGear 3'UTR luciferase reporter plasmids for CXXC4
 SwitchGear Promoter luciferase reporter plasmids for CXXC4
 ThermoFisher Antibody for CXXC4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC4
 Browse compounds at ApexBio
 Search Addgene for plasmids for CXXC4
  Search eBioscience for proteins for CXXC4
  Search eBioscience for elisas for CXXC4
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for CXXC4
 antibodies-online antibodies for CXXC4 (23 products)
 antibodies-online kits for CXXC4 (6 products)
 antibodies-online peptides for CXXC4
 antibodies-online proteins for CXXC4 (5 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      CXXC4 gene at Home site.
Version: 3.12.252 27 Nov 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4