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Aliases for CXXC4 Gene

Aliases for CXXC4 Gene

  • CXXC Finger Protein 4 2 3
  • IDAX 3 4 6
  • Dvl-Binding Protein IDAX (Inhibition Of The Dvl And Axin Complex) 2 3
  • Inhibition Of The Dvl And Axin Complex Protein 3 4
  • CXXC-Type Zinc Finger Protein 4 3
  • CXXC Finger 4 3

External Ids for CXXC4 Gene

Summaries for CXXC4 Gene

GeneCards Summary for CXXC4 Gene

CXXC4 (CXXC Finger Protein 4) is a Protein Coding gene. Diseases associated with CXXC4 include alcohol dependence. Among its related pathways are Wnt signaling pathway (KEGG) and Wnt signaling pathway (KEGG). GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is CXXC5.

UniProtKB/Swiss-Prot for CXXC4 Gene

  • Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXXC4 Gene

Genomics for CXXC4 Gene

Genomic Location for CXXC4 Gene

Start:
104,468,306 bp from pter
End:
104,494,901 bp from pter
Size:
26,596 bases
Orientation:
Minus strand

Genomic View for CXXC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXXC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXXC4 Gene

Regulatory Elements for CXXC4 Gene

Proteins for CXXC4 Gene

  • Protein details for CXXC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2H0-CXXC4_HUMAN
    Recommended name:
    CXXC-type zinc finger protein 4
    Protein Accession:
    Q9H2H0
    Secondary Accessions:

    Protein attributes for CXXC4 Gene

    Size:
    198 amino acids
    Molecular mass:
    20978 Da
    Quaternary structure:
    • Interacts with the PDZ domain of DVL1.

neXtProt entry for CXXC4 Gene

Proteomics data for CXXC4 Gene at MOPED

Post-translational modifications for CXXC4 Gene

No Post-translational modifications

Other Protein References for CXXC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXXC4 Gene

Domains for CXXC4 Gene

Protein Domains for CXXC4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CXXC4_HUMAN
Similarity:
  • Contains 1 CXXC-type zinc finger.:
    • Q9H2H0
genes like me logo Genes that share domains with CXXC4: view

No data available for Gene Families for CXXC4 Gene

Function for CXXC4 Gene

Molecular function for CXXC4 Gene

UniProtKB/Swiss-Prot Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.

Gene Ontology (GO) - Molecular Function for CXXC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0030165 PDZ domain binding IPI 11113207
genes like me logo Genes that share ontologies with CXXC4: view

Phenotypes for CXXC4 Gene

GenomeRNAi human phenotypes for CXXC4:
genes like me logo Genes that share phenotypes with CXXC4: view

miRNA for CXXC4 Gene

miRTarBase miRNAs that target CXXC4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CXXC4 Gene

Localization for CXXC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXXC4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXXC4 Gene COMPARTMENTS Subcellular localization image for CXXC4 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CXXC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11113207
GO:0016023 cytoplasmic membrane-bounded vesicle --
GO:0031410 cytoplasmic vesicle IDA 11113207
genes like me logo Genes that share ontologies with CXXC4: view

Pathways for CXXC4 Gene

genes like me logo Genes that share pathways with CXXC4: view

Pathways by source for CXXC4 Gene

1 BioSystems pathway for CXXC4 Gene
1 KEGG pathway for CXXC4 Gene

Interacting Proteins for CXXC4 Gene

Selected Interacting proteins: Q9H2H0-CXXC4_HUMAN for CXXC4 Gene via I2D

Symbol External ID(s) Details
CTNNB1
DVL1

Gene Ontology (GO) - Biological Process for CXXC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007352 zygotic specification of dorsal/ventral axis ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IDA 11113207
genes like me logo Genes that share ontologies with CXXC4: view

Transcripts for CXXC4 Gene

mRNA/cDNA for CXXC4 Gene

Unigene Clusters for CXXC4 Gene

CXXC finger protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXXC4 Gene

No ASD Table

Relevant External Links for CXXC4 Gene

GeneLoc Exon Structure for
CXXC4
ECgene alternative splicing isoforms for
CXXC4

Expression for CXXC4 Gene

mRNA expression in normal human tissues for CXXC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXXC4 Gene

This gene is overexpressed in Brain - Hypothalamus (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CXXC4 Gene

SOURCE GeneReport for Unigene cluster for CXXC4 Gene Hs.12248

genes like me logo Genes that share expressions with CXXC4: view

Orthologs for CXXC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXXC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXXC4 36
  • 99.27 (n)
  • 100 (a)
CXXC4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXXC4 36
  • 98.65 (n)
  • 99.32 (a)
CXXC4 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXXC4 36
  • 99.18 (n)
  • 99.39 (a)
CXXC4 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxxc4 36
  • 91.44 (n)
  • 91.26 (a)
Cxxc4 16
Cxxc4 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CXXC4 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXXC4 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxxc4 36
  • 94.93 (n)
  • 96.62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cxxc4 36
  • 87.34 (n)
  • 92.47 (a)
Str.12679 36
zebrafish
(Danio rerio)
Actinopterygii cxxc4 37
  • 73 (a)
OneToOne
LOC100006754 36
  • 80.82 (n)
  • 83.81 (a)
Species with no ortholog for CXXC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXXC4 Gene

ENSEMBL:
Gene Tree for CXXC4 (if available)
TreeFam:
Gene Tree for CXXC4 (if available)

Paralogs for CXXC4 Gene

Paralogs for CXXC4 Gene

Selected SIMAP similar genes for CXXC4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CXXC4 Gene

genes like me logo Genes that share paralogs with CXXC4: view

Variants for CXXC4 Gene

Sequence variations from dbSNP and Humsavar for CXXC4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3554 -- 104,469,008(+) TCTCT(C/T)GCTCC utr-variant-3-prime
rs1062017 -- 104,468,461(-) TTTTG(G/T)AAAAC utr-variant-3-prime
rs2298729 -- 104,470,865(-) AGGCC(A/G)TCCCA utr-variant-3-prime
rs2298730 -- 104,470,842(-) TTTAC(A/C)TTCCA utr-variant-3-prime
rs2298731 -- 104,470,182(-) ATGAG(G/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CXXC4 Gene

Variant ID Type Subtype PubMed ID
nsv470062 CNV Loss 18288195

Relevant External Links for CXXC4 Gene

HapMap Linkage Disequilibrium report
CXXC4

Disorders for CXXC4 Gene

(1) MalaCards Diseases for CXXC4 Gene

Search for CXXC4 Gene in MalaCards »

Relevant External Links for CXXC4

Genetic Association Database (GAD)
CXXC4
Human Genome Epidemiology (HuGE) Navigator
CXXC4
genes like me logo Genes that share disorders with CXXC4: view

No data available for UniProtKB/Swiss-Prot for CXXC4 Gene

Publications for CXXC4 Gene

  1. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (PMID: 11113207) Hino S. … Kikuchi A. (Mol. Cell. Biol. 2001) 2 3 4 23
  2. Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. (PMID: 18931698) Kojima T. … Uchida K. (Oncogene 2009) 3 23
  3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 49
  4. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PMID: 20473970) Teixeira F.R. … Gomes M.D. (Proteomics 2010) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CXXC4 Gene

Sources for CXXC4 Gene

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