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Aliases for CXXC4 Gene

Aliases for CXXC4 Gene

  • CXXC Finger Protein 4 2 3 5
  • Dvl-Binding Protein IDAX (Inhibition Of The Dvl And Axin Complex) 2 3
  • Inhibition Of The Dvl And Axin Complex Protein 3 4
  • IDAX 3 4
  • CXXC-Type Zinc Finger Protein 4 3
  • CXXC Finger 4 3

External Ids for CXXC4 Gene

Previous GeneCards Identifiers for CXXC4 Gene

  • GC04M105853
  • GC04M105747
  • GC04M105609
  • GC04M105389
  • GC04M101128

Summaries for CXXC4 Gene

Entrez Gene Summary for CXXC4 Gene

  • This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for CXXC4 Gene

CXXC4 (CXXC Finger Protein 4) is a Protein Coding gene. Diseases associated with CXXC4 include Renal Cell Carcinoma. Among its related pathways are Signaling by Wnt and WNT mediated activation of DVL. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is CXXC5.

UniProtKB/Swiss-Prot for CXXC4 Gene

  • Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.

Additional gene information for CXXC4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXXC4 Gene

Genomics for CXXC4 Gene

Regulatory Elements for CXXC4 Gene

Enhancers for CXXC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H104486 1.3 ENCODE dbSUPER 0.7 +3.4 3386 9 HDGF PKNOX1 ATF1 FOXA2 SIN3A FEZF1 YY1 GLIS2 ZNF143 ZNF207 CXXC4 CXXC4-AS1
GH04H104499 0.7 ENCODE dbSUPER 0.4 -6.0 -5983 2 RFX1 NR3C1 GABPA GC04P104500 CXXC4
GH04H104497 0.4 dbSUPER 0.7 -3.6 -3578 1 IKZF1 CXXC4 GC04P104500
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXXC4 on UCSC Golden Path with GeneCards custom track

Promoters for CXXC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000171403 1 1800 PKNOX1 FOXA2 TBL1XR1 ZSCAN4 FEZF1 BATF YY1 ZNF366 ETV6 RUNX3

Genomic Location for CXXC4 Gene

Chromosome:
4
Start:
104,468,306 bp from pter
End:
104,494,901 bp from pter
Size:
26,596 bases
Orientation:
Minus strand

Genomic View for CXXC4 Gene

Genes around CXXC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXXC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXXC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXXC4 Gene

Proteins for CXXC4 Gene

  • Protein details for CXXC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2H0-CXXC4_HUMAN
    Recommended name:
    CXXC-type zinc finger protein 4
    Protein Accession:
    Q9H2H0

    Protein attributes for CXXC4 Gene

    Size:
    198 amino acids
    Molecular mass:
    20978 Da
    Quaternary structure:
    • Interacts with the PDZ domain of DVL1.

neXtProt entry for CXXC4 Gene

Post-translational modifications for CXXC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXXC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXXC4 Gene

Domains & Families for CXXC4 Gene

Gene Families for CXXC4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXXC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXXC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXXC4: view

No data available for UniProtKB/Swiss-Prot for CXXC4 Gene

Function for CXXC4 Gene

Molecular function for CXXC4 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.

Gene Ontology (GO) - Molecular Function for CXXC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0030165 PDZ domain binding IPI 11113207
genes like me logo Genes that share ontologies with CXXC4: view
genes like me logo Genes that share phenotypes with CXXC4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CXXC4

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CXXC4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXXC4 Gene

Localization for CXXC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXXC4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXXC4 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CXXC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11113207
GO:0031410 cytoplasmic vesicle IDA 11113207
genes like me logo Genes that share ontologies with CXXC4: view

Pathways & Interactions for CXXC4 Gene

genes like me logo Genes that share pathways with CXXC4: view

Pathways by source for CXXC4 Gene

Interacting Proteins for CXXC4 Gene

Selected Interacting proteins: Q9H2H0-CXXC4_HUMAN for CXXC4 Gene via IID

Gene Ontology (GO) - Biological Process for CXXC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007352 zygotic specification of dorsal/ventral axis ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IDA 11113207
genes like me logo Genes that share ontologies with CXXC4: view

No data available for SIGNOR curated interactions for CXXC4 Gene

Drugs & Compounds for CXXC4 Gene

(1) Drugs for CXXC4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Platinum compounds Pharma 0
genes like me logo Genes that share compounds with CXXC4: view

Transcripts for CXXC4 Gene

Unigene Clusters for CXXC4 Gene

CXXC finger protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CXXC4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CXXC4 Gene

No ASD Table

Relevant External Links for CXXC4 Gene

GeneLoc Exon Structure for
CXXC4
ECgene alternative splicing isoforms for
CXXC4

Expression for CXXC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXXC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXXC4 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.3).

Protein differential expression in normal tissues from HIPED for CXXC4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXXC4 Gene



Protein tissue co-expression partners for CXXC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CXXC4 Gene:

CXXC4

SOURCE GeneReport for Unigene cluster for CXXC4 Gene:

Hs.12248

Evidence on tissue expression from TISSUES for CXXC4 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with CXXC4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXXC4 Gene

Orthologs for CXXC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXXC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXXC4 33 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia CXXC4 33 34
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia CXXC4 33 34
  • 98.65 (n)
rat
(Rattus norvegicus)
Mammalia Cxxc4 33
  • 94.93 (n)
mouse
(Mus musculus)
Mammalia Cxxc4 33 16 34
  • 91.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CXXC4 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CXXC4 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxxc4 33
  • 87.34 (n)
Str.12679 33
zebrafish
(Danio rerio)
Actinopterygii LOC100006754 33
  • 80.82 (n)
cxxc4 34
  • 73 (a)
OneToOne
Species where no ortholog for CXXC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXXC4 Gene

ENSEMBL:
Gene Tree for CXXC4 (if available)
TreeFam:
Gene Tree for CXXC4 (if available)

Paralogs for CXXC4 Gene

Paralogs for CXXC4 Gene

(3) SIMAP similar genes for CXXC4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CXXC4: view

Variants for CXXC4 Gene

Sequence variations from dbSNP and Humsavar for CXXC4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000002205 -- 104,478,637(+) GTATT(A/G)TAAGT intron-variant
rs1000007070 -- 104,488,037(+) AAAGG(A/G)AAGAG intron-variant
rs1000055340 -- 104,478,303(+) TTCTG(A/C)AAATG intron-variant
rs1000117014 -- 104,496,564(+) GACAT(C/T)TATAG intron-variant, upstream-variant-2KB
rs1000238464 -- 104,496,031(+) GCTAT(C/T)CTACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXXC4 Gene

Variant ID Type Subtype PubMed ID
nsv1000196 CNV loss 25217958
nsv1126696 CNV deletion 24896259
nsv470062 CNV loss 18288195
nsv950372 CNV deletion 24416366

Variation tolerance for CXXC4 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXXC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXXC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXXC4 Gene

Disorders for CXXC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXXC4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CXXC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXXC4

Genetic Association Database (GAD)
CXXC4
Human Genome Epidemiology (HuGE) Navigator
CXXC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXXC4
genes like me logo Genes that share disorders with CXXC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXXC4 Gene

Publications for CXXC4 Gene

  1. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (PMID: 11113207) Hino S … Kikuchi A (Molecular and cellular biology 2001) 2 3 4 22 60
  2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 45 60
  3. Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. (PMID: 18931698) Kojima T … Uchida K (Oncogene 2009) 3 22 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. CXXC4 mRNA levels are associated with clinicopathological parameters and survival of myelodysplastic syndrome patients. (PMID: 25085016) Li S … Wang XQ (Leukemia research 2014) 3 60

Products for CXXC4 Gene

Sources for CXXC4 Gene

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