Aliases for CXXC4 Gene
External Ids for CXXC4 Gene
Previous GeneCards Identifiers for CXXC4 Gene
This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
GeneCards Summary for CXXC4 Gene
CXXC4 (CXXC Finger Protein 4) is a Protein Coding gene. Diseases associated with CXXC4 include Renal Cell Carcinoma. Among its related pathways are Signaling by Wnt and WNT mediated activation of DVL. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is CXXC5.
UniProtKB/Swiss-Prot for CXXC4 Gene
Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.