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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXXC4 Gene

protein-coding   GIFtS: 51
GCID: GC04M105389

CXXC Finger Protein 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CXXC Finger Protein 41 2
IDAX2 3 5
Dvl-Binding Protein IDAX (Inhibition Of The Dvl And Axin Complex)1 2
Inhibition Of The Dvl And Axin Complex Protein2 3
CXXC Finger 42
CXXC-Type Zinc Finger Protein 42

External Ids:    HGNC: 245931   Entrez Gene: 803192   Ensembl: ENSG000001687727   OMIM: 6116455   UniProtKB: Q9H2H03   
ORGUL members:         
NONCODE14:n384489 n340194      

Export aliases for CXXC4 gene to outside databases

Previous GC identifers: GC04M105853 GC04M105747 GC04M105609 GC04M101128


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CXXC4 Gene: 
CXXC4 (CXXC finger protein 4) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CXXC4 include alcohol dependence, and alcoholism, and among its related super-pathways are Wnt Signaling Pathway. GO annotations related to this gene include PDZ domain binding and DNA binding. An important paralog of this gene is CXXC5.

UniProtKB/Swiss-Prot: CXXC4_HUMAN, Q9H2H0
Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXXC4 gene promoter:
         NF-1   NF-1/L   Sox5   FOXF2   HFH-1   FOXD3   HNF-3beta   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXXC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXXC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXXC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22-q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q22-q24

CXXC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXXC4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M105389:  view genomic region     (about GC identifiers)

Start:
105,389,469 bp from pter      End:
105,416,058 bp from pter
Size:
26,590 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CXXC4

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXXC4_HUMAN, Q9H2H0 (See protein sequence)
Recommended Name: CXXC-type zinc finger protein 4  
Size: 198 amino acids; 20978 Da
Subunit: Interacts with the PDZ domain of DVL1 (By similarity)
Subcellular location: Cytoplasm (By similarity)

Explore the universe of human proteins at neXtProt for CXXC4: NX_Q9H2H0

CXXC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_079488.2  
ENSEMBL proteins: 
 ENSP00000378248   ENSP00000412267  

Human Recombinant Protein Products for CXXC4: 
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OriGene Protein Over-expression Lysate for CXXC4
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OriGene Custom Protein Services for CXXC4
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Novus Biologicals CXXC4 Proteins
Novus Biologicals CXXC4 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CXXC4 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA11113207
GO:0016023cytoplasmic membrane-bounded vesicle ----
GO:0031410cytoplasmic vesicle IDA11113207

CXXC4 for ontologies           About GeneDecksing



CXXC4 Antibody Products: 
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Cloud-Clone Corp. Antibodies for CXXC4 
ThermoFisher Antibody for CXXC4
LSBio Antibodies in human, mouse, rat for CXXC4 

Assay Products for CXXC4: 
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GenScript Custom Assay Services for CXXC4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CXXC4 
Cloud-Clone Corp. CLIAs for CXXC4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR002857 Znf_CXXC

Graphical View of Domain Structure for InterPro Entry Q9H2H0

ProtoNet protein and cluster: Q9H2H0

UniProtKB/Swiss-Prot: CXXC4_HUMAN, Q9H2H0
Similarity: Contains 1 CXXC-type zinc finger


CXXC4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CXXC4_HUMAN, Q9H2H0
Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity)

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0008270zinc ion binding IEA--
GO:0030165PDZ domain binding IPI11113207
     
CXXC4 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for CXXC4:
 Cells with protrusions  Synthetic lethal with Ras 

     1 MGI phenotypic allele for Cxxc4 (no phenotypes)

CXXC4 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Cxxc4tm1Lex for CXXC4

   inGenious Targeting Laboratory - Custom generated mouse model solutions for CXXC4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXXC4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXXC4 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXXC4 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXXC4
3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXXC4:
hsa-miR-3662 hsa-miR-3647-3p hsa-miR-1284
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CXXC4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXXC4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CXXC4
Sirion Biotech Customized adenovirus for overexpression of CXXC4

Clone
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OriGene clones in human, mouse for CXXC4 (see all 7)
OriGene ORF clones in mouse, rat for CXXC4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXXC4 (NM_025212)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXXC4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC4
Sirion Biotech Customized lentivirus for stable overexpression of CXXC4 
                     Customized lentivirus expression plasmids for stable overexpression of CXXC4 

Cell Line
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GenScript Custom overexpressing Cell Line Services for CXXC4
Search LifeMap BioReagents cell lines for CXXC4
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CXXC4 About                                                                                                See pathways by source

SuperPathContained pathways About
1Wnt signaling pathway
Wnt signaling pathway0.40
Wnt Signaling Pathway NetPath0.37

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for CXXC4
    Wnt Signaling Pathway NetPath


1         Kegg Pathway  (Kegg details for CXXC4):
    Wnt signaling pathway


CXXC4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXXC4

2 Interacting proteins for CXXC4 (Q9H2H03) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DVL1O146403I2D: score=2 
CTNNB1P352223I2D: score=1 
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007352zygotic specification of dorsal/ventral axis ISS--
GO:0016055Wnt receptor signaling pathway IEA--
GO:0030178negative regulation of Wnt receptor signaling pathway IDA11113207

CXXC4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CXXC4

Search CenterWatch for drugs/clinical trials and news about CXXC4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CXXC4 gene: 
NM_025212.2  

Unigene Cluster for CXXC4:

CXXC finger protein 4
Hs.12248  [show with all ESTs]
Unigene Representative Sequence: NM_025212
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000394767(uc003hxg.3) ENST00000466963(uc010ilo.3) ENST00000515509
ENST00000426831
miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXXC4
3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXXC4:
hsa-miR-3662 hsa-miR-3647-3p hsa-miR-1284
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CXXC4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXXC4
Clone
Products:
     
OriGene clones in human, mouse for CXXC4 (see all 7)
OriGene ORF clones in mouse, rat for CXXC4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXXC4 (NM_025212)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXXC4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC4
Sirion Biotech Customized lentivirus for stable overexpression of CXXC4 
                     Customized lentivirus expression plasmids for stable overexpression of CXXC4 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CXXC4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXXC4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXXC4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXXC4

Additional mRNA sequence: 

AF272159.1 AK093871.1 AK125395.1 AK127778.1 AK311455.1 BC119751.1 BC119752.1 CR627201.1 

5 DOTS entries:

DT.91908259  DT.40207358  DT.91728597  DT.100646718  DT.403965 

24/78 AceView cDNA sequences (see all 78):

AK127778 AA769966 F05234 CB269607 BU787845 AI359718 R14709 CB070044 
F01387 D81791 BG428495 AK093871 AI383130 F10382 AK125395 NM_025212 
AI377558 CA435921 Z41890 AL711856 AF272159 BU787568 AL133967 BX491488 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CXXC4 expression in normal human tissues (normalized intensities)      CXXC4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACAAAACTG
CXXC4 Expression
About this image


CXXC4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/13 selected tissues (see all 13) fully expand
 
 Brain (Nervous System)    fully expand to see all 27 entries
         Thalamus
         superior temporal gyrus   
 
 Pancreas (Endocrine System)    fully expand to see all 6 entries
         Endocrine Progenitor Cells Ventral Pancreatic Bud
         Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
         visceral organ/gut/foregut-midgut junction   
 
 Limb (Muscoskeletal System)    fully expand to see all 5 entries
         Pelvic Girdle
         limb/hindlimb/hind-paw   
 
 Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
         autonomic/sympathetic/ganglion   
 
 Tooth (Integumentary System)    fully expand to see all 4 entries
         visceral organ/oral region/upper jaw   

Genevestigator expression for CXXC4

SOURCE GeneReport for Unigene cluster: Hs.12248
    SABiosciences Expression via Pathway-Focused PCR Array including CXXC4: 
          WNT Signaling Pathway in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CXXC4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXXC4
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXXC4
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXXC4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CXXC4 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cxxc41 , 5 CXXC finger 41, 5 96.44(n)1
98.31(a)1
  3 (62.12 cM)5
3194781  NM_001004367.41  NP_001004367.21 
 1342364915 
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.126792 Transcribed sequence with strong similarity to protein more 93.7(n)    BX707307.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1000067541 CXXC-type zinc finger protein 4-like 88.57(n)
93.02(a)
  100006754  XM_001345382.1  XP_001345418.1 


ENSEMBL Gene Tree for CXXC4 (if available)
TreeFam Gene Tree for CXXC4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CXXC4 gene
CXXC52  
3 SIMAP similar genes for CXXC4 using alignment to 2 protein entries:     CXXC4_HUMAN (see all proteins):
TET3    CXXC5    TET1

CXXC4 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CXXC4
PGOHUM00000240687


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/441 SNPs in CXXC4 are shown (see all 441)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2008942221,2
C--105388986(+) CATCT-/AGGAGTA 1 -- ds50010--------
rs578113931,2
C--105389092(+) GTAAG-/AAAAAA 1 -- ds50010--------
rs789123191,2
C--105389169(+) ATTCAG/ATTCTT 1 -- ds50014Minor allele frequency- A:0.20CSA WA NA EA 360
rs599441481,2
C--105389286(+) AAAAA-/ATCCCT 1 -- ds50010--------
rs1144068321,2
C,F--105389413(+) ATATGC/TTCATT 1 -- ds50011Minor allele frequency- T:0.02NA 120
rs1466230571,2
--105389470(+) TTTTGA/GGTACT 1 -- ut310--------
rs586128731,2
C--105389550(+) TTTTTT/-ACAGT 1 -- ut311Minor allele frequency- -:0.00NA 2
rs1414252731,2
--105389599(+) TTTCTC/TTAATA 1 -- ut310--------
rs1828527311,2
--105389747(+) GGCCCA/GTGTTC 1 -- ut310--------
rs1880127051,2
--105389773(+) TGCAAC/TTGTGA 1 -- ut310--------

HapMap Linkage Disequilibrium report for CXXC4 (105389469 - 105416058 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CXXC4:    About this table     
Variant IDTypeSubtypePubMed ID
nsv470062CNV Loss18288195

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CXXC4
DNA2.0 Custom Variant and Variant Library Synthesis for CXXC4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 611645    OMIM disorders: --

3 diseases for CXXC4:    About MalaCards
alcohol dependence    alcoholism    renal cell carcinoma


CXXC4 for disorders           About GeneDecksing

Genetic Association Database (GAD): CXXC4
Human Genome Epidemiology (HuGE) Navigator: CXXC4 (2 documents)

Export disorders for CXXC4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CXXC4 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CXXC4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (PubMed id 11113207)1, 2, 3, 9 Hino S.... Kikuchi A. (2001)
  2. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (2010)
  3. Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. (PubMed id 18931698)1, 9 Kojima T....Uchida K. (2009)
  4. Modulation of TET2 expression and 5-methylcytosine oxi dation by the CXXC domain protein IDAX. (PubMed id 23563267)1 Ko M....Rao A. (2013)
  5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
  7. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)1 Teixeira F.R.... Gomes M.D. (2010)
  8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
  9. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (2007)
  10. A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study. (PubMed id 17903305)4 Murabito J.M....Hwang S.J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 80319 HGNC: 24593 AceView: CXXC4 Ensembl:ENSG00000168772 euGenes: HUgn80319
ECgene: CXXC4 Kegg: 80319 H-InvDB: CXXC4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CXXC4 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CXXC4 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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