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Aliases for CXXC4 Gene

Aliases for CXXC4 Gene

  • CXXC Finger Protein 4 2 3
  • Dvl-Binding Protein IDAX (Inhibition Of The Dvl And Axin Complex) 2 3
  • Inhibition Of The Dvl And Axin Complex Protein 3 4
  • IDAX 3 4
  • CXXC Finger 4 3

External Ids for CXXC4 Gene

Previous GeneCards Identifiers for CXXC4 Gene

  • GC04M105853
  • GC04M105747
  • GC04M105609
  • GC04M105389
  • GC04M101128

Summaries for CXXC4 Gene

Entrez Gene Summary for CXXC4 Gene

  • This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for CXXC4 Gene

CXXC4 (CXXC Finger Protein 4) is a Protein Coding gene. Diseases associated with CXXC4 include renal cell carcinoma. Among its related pathways are Signaling by GPCR and Wnt signaling pathway (KEGG). GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is CXXC5.

UniProtKB/Swiss-Prot for CXXC4 Gene

  • Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXXC4 Gene

Genomics for CXXC4 Gene

Regulatory Elements for CXXC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CXXC4 Gene

Chromosome:
4
Start:
104,468,306 bp from pter
End:
104,494,901 bp from pter
Size:
26,596 bases
Orientation:
Minus strand

Genomic View for CXXC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXXC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXXC4 Gene

Proteins for CXXC4 Gene

  • Protein details for CXXC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2H0-CXXC4_HUMAN
    Recommended name:
    CXXC-type zinc finger protein 4
    Protein Accession:
    Q9H2H0

    Protein attributes for CXXC4 Gene

    Size:
    198 amino acids
    Molecular mass:
    20978 Da
    Quaternary structure:
    • Interacts with the PDZ domain of DVL1.

neXtProt entry for CXXC4 Gene

Proteomics data for CXXC4 Gene at MOPED

Post-translational modifications for CXXC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXXC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CXXC4 Gene

Domains & Families for CXXC4 Gene

Gene Families for CXXC4 Gene

Protein Domains for CXXC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXXC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2H0

UniProtKB/Swiss-Prot:

CXXC4_HUMAN :
  • Contains 1 CXXC-type zinc finger.
Similarity:
  • Contains 1 CXXC-type zinc finger.
genes like me logo Genes that share domains with CXXC4: view

Function for CXXC4 Gene

Molecular function for CXXC4 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.

Gene Ontology (GO) - Molecular Function for CXXC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0030165 PDZ domain binding IPI 11113207
genes like me logo Genes that share ontologies with CXXC4: view

Phenotypes for CXXC4 Gene

genes like me logo Genes that share phenotypes with CXXC4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXXC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CXXC4 Gene

Localization for CXXC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXXC4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXXC4 Gene COMPARTMENTS Subcellular localization image for CXXC4 gene
Compartment Confidence
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CXXC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA 11113207
GO:0016023 cytoplasmic membrane-bounded vesicle --
GO:0031410 cytoplasmic vesicle IDA 11113207
genes like me logo Genes that share ontologies with CXXC4: view

Pathways & Interactions for CXXC4 Gene

genes like me logo Genes that share pathways with CXXC4: view

Pathways by source for CXXC4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • WNT Signaling Pathway in human,mouse,rat

Interacting Proteins for CXXC4 Gene

Selected Interacting proteins: Q9H2H0-CXXC4_HUMAN for CXXC4 Gene via I2D

Symbol External ID(s) Details
CTNNB1
DVL1

Gene Ontology (GO) - Biological Process for CXXC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007352 zygotic specification of dorsal/ventral axis ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IDA 11113207
genes like me logo Genes that share ontologies with CXXC4: view

No data available for SIGNOR curated interactions for CXXC4 Gene

Drugs & Compounds for CXXC4 Gene

(1) Drugs for CXXC4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Platinum compounds Pharma 0
genes like me logo Genes that share compounds with CXXC4: view

Transcripts for CXXC4 Gene

mRNA/cDNA for CXXC4 Gene

Unigene Clusters for CXXC4 Gene

CXXC finger protein 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXXC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXXC4 Gene

No ASD Table

Relevant External Links for CXXC4 Gene

GeneLoc Exon Structure for
CXXC4
ECgene alternative splicing isoforms for
CXXC4

Expression for CXXC4 Gene

mRNA expression in normal human tissues for CXXC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXXC4 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.3).

Protein differential expression in normal tissues from HIPED for CXXC4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXXC4 Gene



SOURCE GeneReport for Unigene cluster for CXXC4 Gene Hs.12248

genes like me logo Genes that share expression patterns with CXXC4: view

Protein tissue co-expression partners for CXXC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CXXC4 Gene

Orthologs for CXXC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXXC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CXXC4 35
  • 98.65 (n)
  • 99.32 (a)
CXXC4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXXC4 35
  • 99.18 (n)
  • 99.39 (a)
CXXC4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxxc4 35
  • 91.44 (n)
  • 91.26 (a)
Cxxc4 16
Cxxc4 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CXXC4 35
  • 99.27 (n)
  • 100 (a)
CXXC4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxxc4 35
  • 94.93 (n)
  • 96.62 (a)
oppossum
(Monodelphis domestica)
Mammalia CXXC4 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXXC4 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxxc4 35
  • 87.34 (n)
  • 92.47 (a)
Str.12679 35
zebrafish
(Danio rerio)
Actinopterygii LOC100006754 35
  • 80.82 (n)
  • 83.81 (a)
cxxc4 36
  • 73 (a)
OneToOne
Species with no ortholog for CXXC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXXC4 Gene

ENSEMBL:
Gene Tree for CXXC4 (if available)
TreeFam:
Gene Tree for CXXC4 (if available)

Paralogs for CXXC4 Gene

Paralogs for CXXC4 Gene

(3) SIMAP similar genes for CXXC4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CXXC4 Gene

genes like me logo Genes that share paralogs with CXXC4: view

Variants for CXXC4 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXXC4 Gene

Variant ID Type Subtype PubMed ID
nsv470062 CNV Loss 18288195

Variation tolerance for CXXC4 Gene

Residual Variation Intolerance Score: 31.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXXC4 Gene

HapMap Linkage Disequilibrium report
CXXC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CXXC4 Gene

Disorders for CXXC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXXC4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association
Search CXXC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXXC4

Genetic Association Database (GAD)
CXXC4
Human Genome Epidemiology (HuGE) Navigator
CXXC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXXC4
genes like me logo Genes that share disorders with CXXC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXXC4 Gene

Publications for CXXC4 Gene

  1. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (PMID: 11113207) Hino S. … Kikuchi A. (Mol. Cell. Biol. 2001) 2 23 67
  2. Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. (PMID: 18931698) Kojima T. … Uchida K. (Oncogene 2009) 23 67
  3. Identification and characterization of FBXL19 gene in silico. (PMID: 15547684) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 23 67
  4. CXXC4 mRNA levels are associated with clinicopathological parameters and survival of myelodysplastic syndrome patients. (PMID: 25085016) Li S. … Wang X.Q. (Leuk. Res. 2014) 67
  5. New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling. (PMID: 25064842) Lu H. … Wang X. (FEBS Lett. 2014) 67

Products for CXXC4 Gene

Sources for CXXC4 Gene

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