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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXXC4 Gene

protein-coding   GIFtS: 50
GCID: GC04M105389

CXXC finger protein 4

 Explore 4 diseases affiliated with
CXXC4 via our new
 Human Malady Compendium 
Biological research products
for CXXC4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CXXC Finger Protein 41 2
IDAX1 2 3 5
Inhibition Of The Dvl And Axin Complex Protein2 3
CXXC Finger 42
CXXC-Type Zinc Finger Protein 42
Dvl-Binding Protein IDAX (Inhibition Of The Dvl And Axin Complex)2

External Ids:    HGNC: 245931   Entrez Gene: 803192   Ensembl: ENSG000001687727   OMIM: 6116455   UniProtKB: Q9H2H03   
ORGUL members:         
NONCODE:n384489 n340194    

Export aliases for CXXC4 gene to outside databases

Previous GC identifers: GC04M105853 GC04M105747 GC04M105609 GC04M101128


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CXXC4_HUMAN, Q9H2H0
Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXXC4 gene promoter:
         NF-1   NF-1/L   Sox5   FOXF2   HFH-1   FOXD3   HNF-3beta   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXXC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXXC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXXC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22-q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q22-q24

CXXC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXXC4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M105389:  view genomic region     (about GC identifiers)

Start:
105,389,469 bp from pter      End:
105,416,058 bp from pter
Size:
26,590 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CXXC4

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CXXC4_HUMAN, Q9H2H0 (See protein sequence)
Recommended Name: CXXC-type zinc finger protein 4  
Size: 198 amino acids; 20978 Da
Subunit: Interacts with the PDZ domain of DVL1 (By similarity)
Subcellular location: Cytoplasm (By similarity)

Explore the universe of human proteins at neXtProt for CXXC4: NX_Q9H2H0

CXXC4 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_079488.2  
ENSEMBL proteins: 
 ENSP00000378248   ENSP00000412267  

Human Recombinant Protein Products for CXXC4: 
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Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: CXXC4
OriGene Custom Protein Services for CXXC4 
GenScript Custom Purified and Recombinant Proteins Services for CXXC4
Novus Biologicals CXXC4 Proteins
Novus Biologicals CXXC4 Lysate
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for CXXC4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA11113207
GO:0016023cytoplasmic membrane-bounded vesicle IEA--
GO:0031410cytoplasmic vesicle IDA11113207

CXXC4 for ontologies           About GeneDecksing



CXXC4 Antibody Products: 
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Novus Biologicals CXXC4 Antibodies
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Uscn Antibodies for CXXC4
ThermoFisher Antibody for CXXC4

Assay Products for CXXC4: 
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GenScript Custom Assay Services for CXXC4
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for CXXC4


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CXXC4 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR002857 Znf_CXXC

Graphical View of Domain Structure for InterPro Entry Q9H2H0

ProtoNet protein and cluster: Q9H2H0

UniProtKB/Swiss-Prot: CXXC4_HUMAN, Q9H2H0
Similarity: Contains 1 CXXC-type zinc finger


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CXXC4_HUMAN, Q9H2H0
Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity)

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0008270zinc ion binding IEA--
GO:0030165PDZ domain binding IPI11113207
     
CXXC4 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for CXXC4:
 Cells with protrusions  Synthetic lethal with Ras 

     1 MGI phenotypic allele for Cxxc4 (no phenotypes)

CXXC4 for phenotypes           About GeneDecksing

Animal Models:
     Mouse knock-out Cxxc4tm1Lex for CXXC4
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CXXC4 

miRNA
Products:
    
OriGene 3'-UTR Clone: CXXC4
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXXC4
3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXXC4:
hsa-miR-3662 hsa-miR-3647-3p hsa-miR-1284
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXXC4 (see all 7)
OriGene shRNA RFP: CXXC4
OriGene siRNA: CXXC4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXXC4
Sirion Biotech Custom design and validation of potent shRNA sequences against CXXC4 

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CXXC4
Sirion Biotech Customized adenovirus for overexpression of CXXC4 
Sirion Biotech Customized adenovirus for potent knockdown of CXXC4

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXXC4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXXC4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: CXXC4 (NM_025212)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXXC4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC4 

Cell Line
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Search LifeMap BioReagents cell lines for CXXC4
Sirion Biotech Customized stable knockdown cell line services for CXXC4 
Sirion Biotech Customized inducible knockdown cell line services for CXXC4
Sirion Biotech Customized stable overexpressing cell line services for CXXC4
Sirion Biotech Customized inducible overexpressing cell line services for CXXC4

In Situ Assay
Products:
   

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXXC4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Wnt Signaling Pathway
Wnt signaling pathway0.30
Wnt Signaling Pathway NetPath0.22

Pathway sources
See GeneCards unified pathways
Show all pathways


1 BioSystems Pathway for CXXC4 
    Wnt Signaling Pathway NetPath


1         Kegg Pathway  (Kegg details for CXXC4):
    Wnt signaling pathway


CXXC4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXXC4

2 Interacting proteins for CXXC4 (Q9H2H03) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DVL1O146403I2D: score=2 
CTNNB1P352223I2D: score=1 
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007352zygotic specification of dorsal/ventral axis ISS--
GO:0016055Wnt receptor signaling pathway IEA--
GO:0030178negative regulation of Wnt receptor signaling pathway IDA11113207

CXXC4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CXXC4
Search CenterWatch for drugs/clinical trials and news about CXXC4 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CXXC4 gene: 
NM_025212.2  

Unigene Cluster for CXXC4:

CXXC finger protein 4
Hs.12248  [show with all ESTs]
Unigene Representative Sequence: NM_025212
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000394767(uc003hxg.3) ENST00000466963(uc010ilo.3) ENST00000515509
ENST00000426831

miRNA
Products:
     
OriGene 3'-UTR Clone: CXXC4
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXXC4
3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXXC4:
hsa-miR-3662 hsa-miR-3647-3p hsa-miR-1284
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXXC4 (see all 7)
OriGene shRNA RFP: CXXC4
OriGene siRNA: CXXC4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXXC4
Sirion Biotech Custom design and validation of potent shRNA sequences against CXXC4 
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXXC4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXXC4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: CXXC4 (NM_025212)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXXC4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC4 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXXC4
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXXC4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXXC4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXXC4

Additional cDNA sequence: 

AF272159.1 AK093871.1 AK125395.1 AK127778.1 AK311455.1 BC119751.1 BC119752.1 CR627201.1 

5 DOTS entries:

DT.91908259  DT.40207358  DT.91728597  DT.100646718  DT.403965 

24/78 AceView cDNA sequences (see all 78):

R14709 CB269607 BU787845 F05234 AI359718 AK127778 CB070044 AA769966 
CB068467 BX491488 BM352509 AF272159 AA708035 CA435921 CR627201 F01387 
AK125395 AI377558 F10382 F12774 BU787568 AK093871 AW028123 AL711856 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CXXC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAAAACTG
CXXC4 Expression
About this image

CXXC4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
EyeRetinaEye
Head MesenchymeHead MesenchymeHead Mesenchyme
LimbAutopodLimb
LimbStylopodLimb
LimbZeugopodLimb
Spinal CordPresumptive Spinal CordSpinal Cord
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Posterior foregut-like cells (A scalable, suspensi...)

Genevestigator expression for CXXC4

SOURCE GeneReport for Unigene cluster: Hs.12248
    SABiosciences Expression via Pathway-Focused PCR Array including CXXC4: 
          WNT Signaling Pathway in human mouse rat

Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXXC4
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXXC4
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXXC4
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXXC4
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXXC4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CXXC4 gene from 2/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.126792 Transcribed sequence with strong similarity to protein more 93.7(n)    BX707307.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1000067541 CXXC-type zinc finger protein 4-like 88.57(n)
93.02(a)
  100006754  XM_001345382.1  XP_001345418.1 


ENSEMBL Gene Tree for CXXC4 (if available)
TreeFam Gene Tree for CXXC4 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CXXC4 gene
CXXC52  
2 SIMAP similar genes for CXXC4 using alignment to 2 protein entries:     CXXC4_HUMAN (see all proteins):
CXXC5    TET1

CXXC4 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CXXC4
PGOHUM00000240687


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/378 NCBI SNPs in CXXC4 are shown (see all 378    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2008942221,2
--105388986(+) ATCTC-/AGAGTAT 1 -- ds50010--------
rs578113931,2
C--105389092(+) GTAAG-/AAAAAA 1 -- ds50010--------
rs789123191,2
--105389169(+) ATTCAG/ATTCTT 1 -- ds50014Minor allele frequency- A:0.20CSA WA NA EA 360
rs1452485831,2
C--105389285(+) AGGAG-/AAAAAA 1 -- ds50010--------
rs599441481,2
C--105389287(+) AAAAA-/ATCCCT 1 -- ds50010--------
rs1144068321,2
F--105389413(+) ATATGC/TTCATT 1 -- ds50011Minor allele frequency- T:0.02NA 120
rs1466230571,2
--105389470(+) TTTTGA/GGTACT 1 -- ut310--------
rs586128731,2
C--105389551(+) TTTTTT/-ACAGT 1 -- ut311Minor allele frequency- -:0.00NA 2
rs1414252731,2
--105389599(+) TTTCTC/TTAATA 1 -- ut310--------
rs1828527311,2
--105389747(+) GGCCCA/GTGTTC 1 -- ut310--------

HapMap Linkage Disequilibrium report for CXXC4 (105389469 - 105416058 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CXXC4: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXXC4
DNA2.0 Custom Variant and Variant Library Synthesis for CXXC4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CXXC4 for disorders           About GeneDecksing

OMIM gene information: 611645    OMIM disorders: --

4 diseases for CXXC4:    About MalaCards
alcohol dependence    renal cell carcinoma    alcoholism    carcinoma

Human Genome Epidemiology (HuGE) Navigator: CXXC4 (2 documents)

Export disorders for CXXC4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CXXC4 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CXXC4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (PubMed id 11113207)1, 2, 3, 9 Hino S.... Kikuchi A. (2001)
  2. Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. (PubMed id 18931698)1, 9 Kojima T....Uchida K. (2009)
  3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
  5. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
  6. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)1 Teixeira F.R.... Gomes M.D. (2010)
  7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 80319 HGNC: 24593 AceView: CXXC4 Ensembl:ENSG00000168772 euGenes: HUgn80319
ECgene: CXXC4 Kegg: 80319 H-InvDB: CXXC4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CXXC4 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CXXC4 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CXXC4 gene:
Search GeneIP for patents involving CXXC4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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 EMD Millipore Custom Antibody & Bulk Services
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 Browse OriGene Antibodies   OriGene shRNA RFP for CXXC4  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXXC4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXXC4  
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 OriGene Custom Antibody Services for CXXC4   OriGene Custom Protein Services for CXXC4  
 OriGene Custom Immunoassay Development  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CXXC4
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXXC4
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXXC4
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 GenScript Custom Purified and Recombinant Proteins Services for CXXC4 GenScript cDNA clones with any tag delivered in your preferred vector for CXXC4
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 Regulatory tfbs in CXXC4 promoter
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
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 Search for Antibodies for CXXC4 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for CXXC4
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 CXXC4 Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for CXXC4
 Gene Synthesis
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 Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CXXC4
 Browse SwitchGear 3'UTR luciferase reporter plasmids for CXXC4
 SwitchGear Promoter luciferase reporter plasmids for CXXC4
 ThermoFisher Antibody for CXXC4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC4
 inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CXXC4
Sirion Biotech Customized:
 stable knockdown cell line services for CXXC4
 inducible knockdown cell line services for CXXC4
 design and validation of potent shRNA sequences against CXXC4
 adenovirus for potent knockdown of CXXC4
 adenovirus for overexpression of CXXC4
 stable overexpressing cell line services for CXXC4
 inducible overexpressing cell line services for CXXC4
       
GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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