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Aliases for CXXC1 Gene

Aliases for CXXC1 Gene

  • CXXC Finger Protein 1 2 3 5
  • DNA-Binding Protein With PHD Finger And CXXC Domain 2 3
  • PHD Finger And CXXC Domain-Containing Protein 1 3 4
  • CXXC Finger 1 (PHD Domain) 2 3
  • CpG Binding Protein 2 3
  • CpG-Binding Protein 3 4
  • PCCX1 3 4
  • PHF18 3 4
  • CFP1 3 4
  • CGBP 3 4
  • Zinc Finger, CpG Binding-Type Containing 1 3
  • CpG Binding-Type Containing 1 2
  • 2410002I16Rik 3
  • 5830420C16Rik 3
  • Zinc Finger 2
  • HsT2645 3
  • ZCGPC1 3
  • HCGBP 3
  • SPP1 3

External Ids for CXXC1 Gene

Previous GeneCards Identifiers for CXXC1 Gene

  • GC18M046061
  • GC18M046062
  • GC18M047808
  • GC18M044663

Summaries for CXXC1 Gene

Entrez Gene Summary for CXXC1 Gene

  • This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]

GeneCards Summary for CXXC1 Gene

CXXC1 (CXXC Finger Protein 1) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Signaling by GPCR. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and unmethylated CpG binding.

UniProtKB/Swiss-Prot for CXXC1 Gene

  • Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.

Gene Wiki entry for CXXC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXXC1 Gene

Genomics for CXXC1 Gene

Regulatory Elements for CXXC1 Gene

Promoters for CXXC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CXXC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXXC1 Gene

Chromosome:
18
Start:
50,282,343 bp from pter
End:
50,288,322 bp from pter
Size:
5,980 bases
Orientation:
Minus strand

Genomic View for CXXC1 Gene

Genes around CXXC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXXC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXXC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXXC1 Gene

Proteins for CXXC1 Gene

  • Protein details for CXXC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0U4-CXXC1_HUMAN
    Recommended name:
    CXXC-type zinc finger protein 1
    Protein Accession:
    Q9P0U4
    Secondary Accessions:
    • B2RC03
    • Q8N2W4
    • Q96BC8
    • Q9P2V7

    Protein attributes for CXXC1 Gene

    Size:
    656 amino acids
    Molecular mass:
    75712 Da
    Quaternary structure:
    • Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1 HCFC1 and DPY30. Interacts with SETD1A. Interacts with ZNF335.

    Three dimensional structures from OCA and Proteopedia for CXXC1 Gene

    Alternative splice isoforms for CXXC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXXC1 Gene

Proteomics data for CXXC1 Gene at MOPED

Post-translational modifications for CXXC1 Gene

Other Protein References for CXXC1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CXXC1 (CXXC1)

No data available for DME Specific Peptides for CXXC1 Gene

Domains & Families for CXXC1 Gene

Gene Families for CXXC1 Gene

Suggested Antigen Peptide Sequences for CXXC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0U4

UniProtKB/Swiss-Prot:

CXXC1_HUMAN :
  • The acidic domain carries the potential to activate transcription.
  • Contains 1 CXXC-type zinc finger.
Domain:
  • The acidic domain carries the potential to activate transcription.
Similarity:
  • Contains 1 CXXC-type zinc finger.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with CXXC1: view

Function for CXXC1 Gene

Molecular function for CXXC1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.

Gene Ontology (GO) - Molecular Function for CXXC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17998332
GO:0042800 contributes_to histone methyltransferase activity (H3-K4 specific) IDA 17355966
genes like me logo Genes that share ontologies with CXXC1: view
genes like me logo Genes that share phenotypes with CXXC1: view

Animal Models for CXXC1 Gene

MGI Knock Outs for CXXC1:

Animal Model Products

CRISPR Products

miRNA for CXXC1 Gene

miRTarBase miRNAs that target CXXC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXXC1 Gene

Localization for CXXC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXXC1 Gene

Nucleus speckle. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXXC1 Gene COMPARTMENTS Subcellular localization image for CXXC1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CXXC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0048188 Set1C/COMPASS complex IDA 17998332
genes like me logo Genes that share ontologies with CXXC1: view

Pathways & Interactions for CXXC1 Gene

genes like me logo Genes that share pathways with CXXC1: view

Gene Ontology (GO) - Biological Process for CXXC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 10688657
GO:0051568 histone H3-K4 methylation IDA 17355966
genes like me logo Genes that share ontologies with CXXC1: view

No data available for SIGNOR curated interactions for CXXC1 Gene

Drugs & Compounds for CXXC1 Gene

(1) Additional Compounds for CXXC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXXC1: view

Transcripts for CXXC1 Gene

Unigene Clusters for CXXC1 Gene

CXXC finger protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXXC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - - - -
SP7: -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:

ExUns: 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17a · 17b · 17c
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12: - -
SP13:

Relevant External Links for CXXC1 Gene

GeneLoc Exon Structure for
CXXC1
ECgene alternative splicing isoforms for
CXXC1

Expression for CXXC1 Gene

mRNA expression in normal human tissues for CXXC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CXXC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.7) and CD8 Tcells (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CXXC1 Gene



SOURCE GeneReport for Unigene cluster for CXXC1 Gene Hs.180933

mRNA Expression by UniProt/SwissProt for CXXC1 Gene

Q9P0U4-CXXC1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with CXXC1: view

Protein tissue co-expression partners for CXXC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CXXC1 Gene

Orthologs for CXXC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CXXC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CXXC1 35
  • 91.11 (n)
  • 97.1 (a)
CXXC1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXXC1 35
  • 92.73 (n)
  • 98.48 (a)
CXXC1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxxc1 35
  • 89.43 (n)
  • 96.19 (a)
Cxxc1 16
Cxxc1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CXXC1 35
  • 99.9 (n)
  • 100 (a)
CXXC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxxc1 35
  • 89.92 (n)
  • 96.34 (a)
oppossum
(Monodelphis domestica)
Mammalia CXXC1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXXC1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXXC1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxxc1 35
  • 73.54 (n)
  • 77.99 (a)
Str.7156 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15518 35
zebrafish
(Danio rerio)
Actinopterygii cxxc1 35
  • 67.67 (n)
  • 71.05 (a)
zgc55527 35
cxxc1 36
  • 71 (a)
OneToMany
cxxc1l 36
  • 71 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5099 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004704 35
  • 55.08 (n)
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cfp1 35
  • 53.84 (n)
  • 48.22 (a)
Cfp1 36
  • 32 (a)
OneToMany
CG17440 36
  • 26 (a)
OneToMany
CG3347 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfp-1 36
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for CXXC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CXXC1 Gene

ENSEMBL:
Gene Tree for CXXC1 (if available)
TreeFam:
Gene Tree for CXXC1 (if available)

Paralogs for CXXC1 Gene

(2) SIMAP similar genes for CXXC1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CXXC1 Gene

genes like me logo Genes that share paralogs with CXXC1: view

No data available for Paralogs for CXXC1 Gene

Variants for CXXC1 Gene

Sequence variations from dbSNP and Humsavar for CXXC1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs2276363 -- 50,286,708(-) TGACA(C/G)TGGCA intron-variant
rs2276364 -- 50,285,505(-) CATGT(C/T)GGTAC intron-variant
rs2276365 -- 50,285,299(-) TGGGG(A/C/T)GGGGC intron-variant
rs2276366 -- 50,284,935(-) TAATG(A/C)GGAGA intron-variant
rs2276367 -- 50,284,361(-) CTGAG(A/G)GGTTC intron-variant

Variation tolerance for CXXC1 Gene

Residual Variation Intolerance Score: 3.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXXC1 Gene

HapMap Linkage Disequilibrium report
CXXC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CXXC1 Gene

Disorders for CXXC1 Gene

Relevant External Links for CXXC1

Genetic Association Database (GAD)
CXXC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXXC1

No disorders were found for CXXC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXXC1 Gene

Publications for CXXC1 Gene

  1. Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. (PMID: 10688657) Voo K.S. … Skalnik D.G. (Mol. Cell. Biol. 2000) 2 3 4 23 67
  2. PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis. (PMID: 10799292) Fujino T. … Takano T. (Biochem. Biophys. Res. Commun. 2000) 2 3 23
  3. Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. (PMID: 18082152) Ansari K.I. … Mandal S.S. (Biochim. Biophys. Acta 2008) 3 23
  4. CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line. (PMID: 17328666) Young S.R. … Skalnik D.G. (DNA Cell Biol. 2007) 3 23
  5. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. (PMID: 16253997) Lee J.-H. … Skalnik D.G. (J. Biol. Chem. 2005) 3 23

Products for CXXC1 Gene

Sources for CXXC1 Gene

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