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Aliases for CXXC1 Gene

Aliases for CXXC1 Gene

  • CXXC Finger Protein 1 2 3
  • DNA-Binding Protein With PHD Finger And CXXC Domain 2 3
  • PHD Finger And CXXC Domain-Containing Protein 1 3 4
  • CXXC Finger 1 (PHD Domain) 2 3
  • CpG Binding Protein 2 3
  • CpG-Binding Protein 3 4
  • PCCX1 3 4
  • PHF18 3 4
  • CFP1 3 4
  • CGBP 3 4
  • Zinc Finger, CpG Binding-Type Containing 1 3
  • CXXC-Type Zinc Finger Protein 1 3
  • CpG Binding-Type Containing 1 2
  • 2410002I16Rik 3
  • 5830420C16Rik 3
  • Zinc Finger 2
  • HsT2645 3
  • ZCGPC1 3
  • HCGBP 3
  • SPP1 3

External Ids for CXXC1 Gene

Summaries for CXXC1 Gene

Entrez Gene Summary for CXXC1 Gene

  • Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001 [PubMed 11604496]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CXXC1 Gene

CXXC1 (CXXC Finger Protein 1) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and unmethylated CpG binding.

UniProtKB/Swiss-Prot for CXXC1 Gene

  • Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.

Gene Wiki entry for CXXC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXXC1 Gene

Genomics for CXXC1 Gene

Genomic Location for CXXC1 Gene

50,282,343 bp from pter
50,288,322 bp from pter
5,980 bases
Minus strand

Genomic View for CXXC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXXC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXXC1 Gene

Regulatory Elements for CXXC1 Gene

Proteins for CXXC1 Gene

  • Protein details for CXXC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CXXC-type zinc finger protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RC03
    • Q8N2W4
    • Q96BC8
    • Q9P2V7

    Protein attributes for CXXC1 Gene

    656 amino acids
    Molecular mass:
    75712 Da
    Quaternary structure:
    • Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1 HCFC1 and DPY30. Interacts with SETD1A. Interacts with ZNF335.

    Three dimensional structures from OCA and Proteopedia for CXXC1 Gene

    Alternative splice isoforms for CXXC1 Gene


neXtProt entry for CXXC1 Gene

Proteomics data for CXXC1 Gene at MOPED

Post-translational modifications for CXXC1 Gene

Other Protein References for CXXC1 Gene

No data available for DME Specific Peptides for CXXC1 Gene

Domains for CXXC1 Gene

Gene Families for CXXC1 Gene

  • PHF :Zinc fingers, PHD-type

Suggested Antigen Peptide Sequences for CXXC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The acidic domain carries the potential to activate transcription:
    • Q9P0U4
  • Contains 1 CXXC-type zinc finger.:
    • Q9P0U4
  • Contains 1 PHD-type zinc finger.:
    • Q9P0U4
genes like me logo Genes that share domains with CXXC1: view

Function for CXXC1 Gene

Molecular function for CXXC1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.

Gene Ontology (GO) - Molecular Function for CXXC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 17998332
GO:0008270 zinc ion binding IEA --
GO:0042800 contributes_to histone methyltransferase activity (H3-K4 specific) IDA 17355966
GO:0045322 unmethylated CpG binding IDA 10688657
genes like me logo Genes that share ontologies with CXXC1: view

Phenotypes for CXXC1 Gene

genes like me logo Genes that share phenotypes with CXXC1: view

Animal Models for CXXC1 Gene

MGI Knock Outs for CXXC1:

miRNA for CXXC1 Gene

miRTarBase miRNAs that target CXXC1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CXXC1 Gene

Localization for CXXC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXXC1 Gene

Nucleus speckle. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes.

Subcellular locations from

Jensen Localization Image for CXXC1 Gene COMPARTMENTS Subcellular localization image for CXXC1 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CXXC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0016363 nuclear matrix IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with CXXC1: view

Pathways for CXXC1 Gene

genes like me logo Genes that share pathways with CXXC1: view

Gene Ontology (GO) - Biological Process for CXXC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 10688657
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with CXXC1: view

Compounds for CXXC1 Gene

(1) Novoseek inferred chemical compound relationships for CXXC1 Gene

Compound -log(P) Hits PubMed IDs
cytosine 48.8 1
genes like me logo Genes that share compounds with CXXC1: view

Transcripts for CXXC1 Gene

Unigene Clusters for CXXC1 Gene

CXXC finger protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXXC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - - - -
SP7: -
SP9: -

ExUns: 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17a · 17b · 17c
SP1: - - - -
SP2: - - - -
SP10: - -
SP12: - -

Relevant External Links for CXXC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXXC1 Gene

mRNA expression in normal human tissues for CXXC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CXXC1 Gene

SOURCE GeneReport for Unigene cluster for CXXC1 Gene Hs.180933

mRNA Expression by UniProt/SwissProt for CXXC1 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CXXC1: view

No data available for mRNA differential expression in normal tissues for CXXC1 Gene

Orthologs for CXXC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CXXC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXXC1 35
  • 99.9 (n)
  • 100 (a)
CXXC1 36
  • 100 (a)
(Bos Taurus)
Mammalia CXXC1 35
  • 91.11 (n)
  • 97.1 (a)
CXXC1 36
  • 96 (a)
(Canis familiaris)
Mammalia CXXC1 35
  • 92.73 (n)
  • 98.48 (a)
CXXC1 36
  • 98 (a)
(Mus musculus)
Mammalia Cxxc1 35
  • 89.43 (n)
  • 96.19 (a)
Cxxc1 16
Cxxc1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia CXXC1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia CXXC1 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Cxxc1 35
  • 89.92 (n)
  • 96.34 (a)
(Anolis carolinensis)
Reptilia CXXC1 36
  • 74 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15518 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cxxc1 35
  • 73.54 (n)
  • 77.99 (a)
Str.7156 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5099 35
(Danio rerio)
Actinopterygii cxxc1 35
  • 67.67 (n)
  • 71.05 (a)
cxxc1 36
  • 71 (a)
cxxc1l 36
  • 71 (a)
zgc55527 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004704 35
  • 55.08 (n)
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cfp1 35
  • 53.84 (n)
  • 48.22 (a)
Cfp1 36
  • 32 (a)
CG17440 36
  • 26 (a)
CG3347 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea cfp-1 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for CXXC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CXXC1 Gene

Gene Tree for CXXC1 (if available)
Gene Tree for CXXC1 (if available)

Paralogs for CXXC1 Gene

Selected SIMAP similar genes for CXXC1 Gene using alignment to 5 proteins: Pseudogenes for CXXC1 Gene

genes like me logo Genes that share paralogs with CXXC1: view

No data available for Paralogs for CXXC1 Gene

Variants for CXXC1 Gene

Sequence variations from dbSNP and Humsavar for CXXC1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs2276363 -- 50,286,708(-) TGACA(C/G)TGGCA intron-variant
rs2276364 -- 50,285,505(-) CATGT(C/T)GGTAC intron-variant
rs2276365 -- 50,285,299(-) TGGGG(C/T)GGGGC intron-variant
rs2276366 -- 50,284,935(-) TAATG(A/C)GGAGA intron-variant
rs2276367 -- 50,284,361(-) CTGAG(A/G)GGTTC intron-variant

Relevant External Links for CXXC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CXXC1 Gene

Disorders for CXXC1 Gene

(2) University of Copenhagen DISEASES for CXXC1 Gene

Relevant External Links for CXXC1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with CXXC1: view

No data available for UniProtKB/Swiss-Prot for CXXC1 Gene

Publications for CXXC1 Gene

  1. Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. (PMID: 10688657) Voo K.S. … Skalnik D.G. (Mol. Cell. Biol. 2000) 2 3 4 23
  2. PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis. (PMID: 10799292) Fujino T. … Takano T. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  3. CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals. (PMID: 12200428) Lee J.-H. … Skalnik D.G. (J. Biol. Chem. 2002) 3 4 23
  4. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. (PMID: 16253997) Lee J.-H. … Skalnik D.G. (J. Biol. Chem. 2005) 3 4 23
  5. CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line. (PMID: 17328666) Young S.R. … Skalnik D.G. (DNA Cell Biol. 2007) 3 23

Products for CXXC1 Gene

  • Addgene plasmids for CXXC1

Sources for CXXC1 Gene

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