CXXC1 Gene
protein-coding GIFtS: 56
GCID: GC18M047808
|
|
CXXC finger protein 1(Previous name: CXXC finger 1 (PHD domain) )
| |
Aliases
for CXXC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CXXC Finger Protein 11 2 | | HCGBP1 | | CFP11 2 3 | | CXXC-Type Zinc Finger Protein 12 3 | | CGBP1 2 3 | | PHD Finger And CXXC Domain-Containing Protein 12 3 | | PCCX11 2 3 | | 2410002I16Rik2 | | PHF181 2 3 | | 5830420C16Rik2 | | HsT26451 2 | | CpG Binding Protein2 | | SPP11 2 | | CpG-Binding Protein2 | | ZCGPC11 2 | | DNA-Binding Protein With PHD Finger And CXXC Domain2 | | CXXC Finger 1 (PHD Domain)1 2 | | Zinc Finger, CpG Binding-Type Containing 12 |
Export aliases for CXXC1 gene to outside databasesPrevious GC identifers: GC18M046061 GC18M046062 GC18M044663 |
Summaries
for CXXC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CXXC1:
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulategene expression (Carlone and Skalnik, 2001 (PubMed 11604496)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: CXXC1_HUMAN, Q9P0U4Function: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with apreference for CpGG
Gene Wiki entry for CXXC1
|
Genomic Views
for CXXC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CXXC1 gene promoter:
STAT1 p53 STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CXXC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXXC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q12 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q12CXXC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M047808: view genomic region
(about GC identifiers)
Start:
|
47,808,713 bp from pter |
End:
|
47,814,692 bp from pter |
Size:
|
5,980 bases |
Orientation:
|
minus strand |
|
Proteins
for CXXC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CXXC1_HUMAN, Q9P0U4 (See
protein sequence)Recommended Name: CpG-binding protein Size: 656 amino acids; 75712 Da
Subunit: Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82,RBBP5, ASH2L/ASH2, CXXC1/CFP1 HCFC1 and DPY30. Interacts with SETD1A
Subcellular location: Nucleus speckle. Note=Associated with euchromatin. During mitosis, excluded from condensedchromosomes
6 PDB 3D structures from  and Proteopedia  for CXXC1:3QMB (3D)
3QMC (3D)
3QMD (3D)
3QMG (3D)
3QMH (3D)
3QMI (3D)
Secondary accessions: B2RC03 Q8N2W4 Q96BC8 Q9P2V7Alternative splicing: 2 isoforms: Q9P0U4-1 Q9P0U4-2 Explore the universe of human proteins at neXtProt for CXXC1: NX_Q9P0U4
Post-translational modifications:
May be regulated by proteolysis1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P0U4
CXXC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001095124.1 NP_055408.2
ENSEMBL proteins: ENSP00000390475 ENSP00000285106 ENSP00000467634 ENSP00000465849 ENSP00000468038 ENSP00000465284 Reactome Protein details: Q9P0U4
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CXXC1 for ontologies About GeneDecksing
CXXC1 Antibody Products:
Assay Products for CXXC1: |
Protein
Domains /
Families
for CXXC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CXXC1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9P0U4ProtoNet protein and cluster: Q9P0U4 2 Blocks protein families: IPB001965 Zn-finger-like IPB002857 Zn-finger
UniProtKB/Swiss-Prot: CXXC1_HUMAN, Q9P0U4Domain: The acidic domain carries the potential to activate transcriptionSimilarity: Contains 1 CXXC-type zinc fingerSimilarity: Contains 1 PHD-type zinc finger |
Function
for CXXC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CXXC1_HUMAN, Q9P0U4Function: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with apreference for CpGG
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXXC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXXC1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CXXC1 (NM_001101654) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXXC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CXXC1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Cxxc1tm1Skk for CXXC1
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cxxc1):
CXXC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CXXC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of Chaperone Genes by XBP1(S) | | | 2 | Expression of CXXC1 | | | 3 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for CXXC1
CXXC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXXC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/46 Interacting proteins for CXXC1 (Q9P0U43 ENSP000003904754) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IDA | 10688657 | | GO:0006987 | activation of signaling protein activity involved in unfolded protein response |
TAS | -- | | GO:0030968 | endoplasmic reticulum unfolded protein response |
TAS | -- | | GO:0045893 | positive regulation of transcription, DNA-dependent |
IDA | 10688657 |
CXXC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CXXC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CXXC1 for compounds About GeneDecksing
 Browse Tocris compounds for CXXC1
1 Novoseek chemical compound relationship for CXXC1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cytosine |
48.8 |
1 |
16253997 (1) |
Search CenterWatch for drugs/clinical trials and news about CXXC1
|
Transcripts
for CXXC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CXXC1 gene (2 alternative transcripts): NM_001101654.1 NM_014593.3 Unigene Cluster for CXXC1: CXXC finger protein 1 Hs.180933 [show with all ESTs]Unigene Representative Sequence: NM_00110165417 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000412036(uc002ler.4 uc002leq.4 uc010doy.3) ENST00000285106(uc002lep.4)
ENST00000589940 ENST00000590901 ENST00000587342 ENST00000587170 ENST00000586144
ENST00000586568 ENST00000586502 ENST00000590234 ENST00000591190 ENST00000591474
ENST00000592078 ENST00000589548 ENST00000586837 ENST00000586365 ENST00000587396
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXXC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXXC1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CXXC1 (NM_001101654) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXXC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC1 |
Additional cDNA sequence: AB031069.1 AF149758.1 AK294645.1 AK314886.1 AL136862.1 BC002504.2 BC009188.2 BC014940.2 BC015733.1 BC029922.1 BX647189.1 10 DOTS entries: DT.451915 DT.100788557 DT.95160890 DT.100788556 DT.95160891 DT.92440142 DT.100654108 DT.95160879 DT.441093 DT.92440140 24/247 AceView cDNA sequences (see all 247): BU846496 AA569384 BI767555 CD723125 BE563006 CF141129 AI131133 AL136862 AA236925 AI339596 CA487361 BI918104 AW402704 AA825495 AI365458 AA412234 BM703125 BM824876 AA338532 AA769524 AA644225 AI676109 BM476063 AI040474
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CXXC1 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15a | · | 15b | · | 15c | · | 15d | · | 15e | ^ | 16 | ^ | 17a | · | 17b | · | 17c |
|---|
|
| SP1: | - | | - | | | | - | | - | | | | | | | | | | |
| SP2: | - | | - | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CXXC1
|
Expression
for CXXC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CXXC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCAGTGCCT
About this image
See CXXC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXXC1
SOURCE GeneReport for Unigene cluster: Hs.180933
UniProtKB/Swiss-Prot: CXXC1_HUMAN, Q9P0U4Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including CXXC1: | Parkinson's Disease in human mouse rat | | Epigenetic Chromatin Modification Enzymes in human mouse rat | | Polycomb & Trithorax Complexes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXXC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXXC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXXC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXXC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC1 |
Orthologs
for CXXC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CXXC1 gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cxxc11 , 5 |
CXXC finger 1 (PHD domain)1, 5 |
89.58(n)1
96.8(a)1 |
|
18 (50.70 cM)5
743221 NM_028868.31 NP_083144.11
742162125 |
lizard
(Anolis carolinensis) |
Reptilia |
CXXC16 |
-- |
74(a) |
1 ↔ 1 |
2(69146186-69172992) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.155182 |
Xenopus laevis transcribed sequence with moderate similarity more |
80.9(n) |
|
48046101 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc555272 |
hypothetical protein MGC55527 |
78.96(n) |
|
393304 BC052918.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG174461 |
CG17446 |
50.61(n)
43.88(a) |
|
31880 NM_132328.2 NP_572556.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
F52B11.16 |
Protein F52B11.1, isoform b |
20(a) |
1 ↔ 1 |
IV(14077416-14083534) |
ENSEMBL Gene Tree for CXXC1 (if available)
TreeFam Gene Tree for CXXC1 (if available) |
Paralogs
for CXXC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CXXC1 gene
- MBD12
2 SIMAP similar genes for CXXC1 using alignment to 5 protein entries: CXXC1_HUMAN (see all proteins):FBXL19 PHF8
CXXC1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CXXC1
PGOHUM00000241737
|
Genomic Variants
for CXXC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CXXC1 (47808713 - 47814692 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CXXC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXXC1 |
|
Disorders
/ Diseases
for CXXC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CXXC1 for disorders About GeneDecksing
OMIM gene information: 609150
OMIM disorders: --
9  diseases for CXXC1: About MalaCardsklatskin's tumor intellectual disability chronic lymphocytic leukemia lymphocytic leukemia
parkinson's disease colon cancer leukemia lung cancer
ataxia
2 diseases from the University of Copenhagen DISEASES database for CXXC1:Rett syndrome Klatskin's tumor Export disorders for CXXC1 gene to outside databases
|
Publications
for CXXC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CXXC1 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with CXXC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. (PubMed id 10688657)1, 2, 3, 9 Voo K.S.... Skalnik D.G. (2000)
- PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis. (PubMed id 10799292)1, 2, 3, 9 Fujino T.... Takano T. (2000)
- CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals. (PubMed id 12200428)1, 2, 9 Lee J.-H. and Skalnik D.G. (2002)
- CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. (PubMed id 16253997)1, 2, 9 Lee J.-H. and Skalnik D.G. (2005)
- The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain. (PubMed id 21407193)1, 2 Xu C.... Min J. (2011)
- Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PubMed id 17998332)1, 2 Lee J.H. and Skalnik D.G. (2008)
- Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PubMed id 18838538)1, 2 Wu M....Shilatifard A. (2008)
- Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PubMed id 17355966)1, 2 Lee J.-H.... Skalnik D.G. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
|
External Searches for CXXC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CXXC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CXXC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CXXC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CXXC1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CXXC1 gene:
Search GeneIP for patents involving CXXC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CXXC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CXXC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXXC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXXC1 | | | OriGene Protein Over-expression Lysate for CXXC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CXXC1 | | OriGene 3'-UTR Clone for CXXC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXXC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXXC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CXXC1 | | OriGene Custom Protein Services for CXXC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CXXC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXXC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXXC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXXC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXXC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXXC1 |
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| | | | Search Tocris compounds for CXXC1 |
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 | | | CXXC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXXC1 |
|  |  |  | | | | ThermoFisher Antibodies for CXXC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXXC1 |
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