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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCR7 Gene

protein-coding   GIFtS: 60
GCID: GC02P237476

chemokine (C-X-C motif) receptor 7

(Previous name: chemokine orphan receptor 1 )
(Previous symbol: CMKOR1)
 Explore 20 diseases affiliated with
CXCR7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CXCR7    

Aliases
for CXCR7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-X-C Motif) Receptor 71 2     CXCR-72 3
CMKOR11 2 3 5     RDC-12 3
GPR1591 2 3 5     G-Protein Coupled Receptor 1592 3
RDC11 2 3 5     G-Protein Coupled Receptor RDC1 Homolog2 3
Chemokine Orphan Receptor 11 2 3     C-X-C Chemokine Receptor Type 72
CXC-R72 3     G Protein-Coupled Receptor2

External Ids:    HGNC: 236921   Entrez Gene: 570072   Ensembl: ENSG000001444767   OMIM: 6103765   UniProtKB: P251063   

Export aliases for CXCR7 gene to outside databases

Previous GC identifers: GC02P237143 GC02P229272


Summaries
for CXCR7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CXCR7:
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a
receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its
endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV).
Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: CXCR7_HUMAN, P25106
Function: Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling;
chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin
recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for
CXCL12/SDF1 and, to a lesser extent, for CXCL11. Required for regulation of CXCR4 protein levels in migrating
interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK
pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration,
adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells,
leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role
in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as
coreceptor with CXCR4 for a restricted number of HIV isolates

Gene Wiki entry for CXCR7


Genomic Views
for CXCR7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCR7 gene promoter:
         Max1   GR   Bach2   MyoD   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   POU2F1   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CXCR7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCR7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

CXCR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCR7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P237476:  view genomic region     (about GC identifiers)

Start:
 237,476,430 bp from pter      End:
 237,491,001 bp from pter
Size:
 14,572 bases      Orientation:
 plus strand

Proteins
for CXCR7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CXCR7_HUMAN, P25106 (See protein sequence)
Recommended Name: C-X-C chemokine receptor type 7  
Size: 362 amino acids; 41493 Da
Subunit: Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Early endosome.
Recycling endosome (By similarity). Note=Localized mainly in perinuclear regions in neurons and in early endosomes in
T-lymphocytes and some other cell types, with very low levels detected on the cell surface. May spontaneously cycle
between the plasma membrane and endosomal compartments
Caution: Was originally (PubMed:1675791) thought to be the receptor for VIP
Secondary accessions: A8K6J4 Q53RV4 Q8NE10 Q92938 Q92986

Explore the universe of human proteins at neXtProt for CXCR7: NX_P25106

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P25106

    • CXCR7 Protein expression data from MOPED and PaxDb:    About this image 
    CXCR7 Protein Expression
    REFSEQ proteins: NP_064707.1  
    ENSEMBL proteins: 
     ENSP00000405945   ENSP00000272928  
    Reactome Protein details: P25106
    Human Recombinant Protein Products for CXCR7: 
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    OriGene Protein Over-expression Lysate: CXCR7
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    GenScript Custom Purified and Recombinant Proteins Services for CXCR7
    Novus Biologicals CXCR7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CXCR7

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS--
    GO:0048471perinuclear region of cytoplasm IEA--
    GO:0055037recycling endosome IEA--

    CXCR7 for ontologies           About GeneDecksing



    CXCR7 Antibody Products: 
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    Assay Products for CXCR7: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for CXCR7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CXCR7

    Protein Domains /
    Families
    for CXCR7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CXCR7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001416 RDC1_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P25106

    ProtoNet protein and cluster: P25106

    1 Blocks protein family: IPB001416 RDC1 orphan receptor signature

    UniProtKB/Swiss-Prot: CXCR7_HUMAN, P25106
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for CXCR7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCR7_HUMAN, P25106
    Function: Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling;
    chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin
    recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for
    CXCL12/SDF1 and, to a lesser extent, for CXCL11. Required for regulation of CXCR4 protein levels in migrating
    interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK
    pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration,
    adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells,
    leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role
    in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as
    coreceptor with CXCR4 for a restricted number of HIV isolates
    Induction: Up-regulated during cell differentiation in glioma cells

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016494C-X-C chemokine receptor activity IMP--
         
    CXCR7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CXCR7:
     Decreased Wnt reporter activit  Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Cxcr7):
     cardiovascular system  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  nervous system  respiratory system 

    CXCR7 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for CXCR7: Cxcr7tm1.1Fma Cxcr7tm1.1Dsr
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CXCR7 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCR7
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCR7 (see all 10):
    hsa-miR-3163 hsa-miR-3671 hsa-miR-142-5p hsa-miR-607 hsa-miR-520d-5p hsa-miR-548o hsa-miR-338-5p hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmid: CXCR7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCR7 (see all 7)
    OriGene shRNA RFP: CXCR7
    OriGene siRNA: CXCR7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCR7
    Sirion Biotech Custom design and validation of potent shRNA sequences against CXCR7 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CXCR7 
    Sirion Biotech Customized adenovirus for potent knockdown of CXCR7

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCR7 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCR7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CXCR7 (NM_020311)
    Sino Biological Human cDNA Clone for CXCR7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR7 

    Cell Line
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    LifeMap BioReagents: cell lines associated with CXCR7: PureStem 4D20.8, NCr-fac Progenitor,
    PureStem SK11, NCr-fac & Meso-prx Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor
    Sirion Biotech Customized stable knockdown cell line services for CXCR7 
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    Sirion Biotech Customized inducible overexpressing cell line services for CXCR7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR7


    Pathways & Interactions
    for CXCR7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    		Peptide ligand-binding receptors0.61
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Chemokine receptors bind chemokines
    		Chemokine receptors bind chemokines1.00
    4Selected targets of CREB1
    		Selected targets of CREB11.00
    5Calcium Regulation in the Cardiac Cell
    		Myometrial Relaxation and Contraction Pathways0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CXCR7
        Selected targets of CREB1


    2 BioSystems Pathways for CXCR7 
        Myometrial Relaxation and Contraction Pathways
    GPCRs, Class A Rhodopsin-like

    5/8        Reactome Pathways for CXCR7 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for CXCR7):
        Cytokine-cytokine receptor interaction


    CXCR7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCR7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/146 Interacting proteins for CXCR7 (P251063 ENSP000002729284) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    APLNRENSP000002572544STRING: ENSP00000257254
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0019048virus-host interaction IEA--
    GO:0043066negative regulation of apoptotic process IMP--
    GO:0044419interspecies interaction between organisms ----

    CXCR7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CXCR7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCR7
    Search CenterWatch for drugs/clinical trials and news about CXCR7 

    Transcripts
    for CXCR7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CXCR7 gene (2 alternative transcripts): 
    NM_020311.2  NM_001047841.1  

    Unigene Cluster for CXCR7:

    Chemokine (C-X-C motif) receptor 7
    Hs.471751  [show with all ESTs]
    Unigene Representative Sequence: BC036661
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447924 ENST00000272928(uc010fyq.3 uc002vwd.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCR7
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCR7 (see all 10):
    hsa-miR-3163 hsa-miR-3671 hsa-miR-142-5p hsa-miR-607 hsa-miR-520d-5p hsa-miR-548o hsa-miR-338-5p hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmid: CXCR7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCR7 (see all 7)
    OriGene shRNA RFP: CXCR7
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CXCR7 (NM_020311)
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    Primer
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    Additional cDNA sequence: 

    AF030297.1 AK023507.1 AK291659.1 BC008459.1 BC036661.2 BC038720.1 DQ822477.1 M64749.1 
    U67784.1 

    10 DOTS entries:

    DT.95270731  DT.456342  DT.100673506  DT.65288284  DT.100809392  DT.92422019  DT.121001874  DT.100809387 
    DT.92064866  DT.92422024 

    24/144 AceView cDNA sequences (see all 144):

    T29462 AI492871 AA927383 AK023507 BX483000 AA331166 NM_020311 CD172317 
    AI829881 BQ446586 AA197246 AA309135 BF926353 BC038720 BQ183931 BX110394 
    AW316612 AA905072 AI277740 AA313046 AW771079 BM769858 AW130966 CD677369 

    GeneLoc Exon Structure


    Expression
    for CXCR7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCR7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACACAGTG
    CXCR7 Expression
    About this image

    CXCR7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    CartilageLumbar Intervertebral DiscCartilage
    KidneyMetanephrosKidney
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/16 LifeMap Cells (see all 16) 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See CXCR7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCR7

    SOURCE GeneReport for Unigene cluster: Hs.471751

    UniProtKB/Swiss-Prot: CXCR7_HUMAN, P25106
    Tissue specificity: Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and
    B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain,
    detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed
    in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells.
    Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell
    lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCR7: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCR7
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR7

    Orthologs
    for CXCR7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CXCR7 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CXCR71 chemokine (C-X-C motif) receptor 7 74.63(n)
    75.56(a)    		   428997  NM_001083362.1  NP_001076831.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CXCR76
    		 --
    		 68(a)
    		 1 ↔ 1
    		 1(120160338-120161432)
    African clawed frog
    (Xenopus laevis)    		 Amphibia RDC12 RDC1 like protein 71.65(n)    AJ312935.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb9002 sbcb900 78.6(n)   386790  CF673255.1 


    ENSEMBL Gene Tree for CXCR7 (if available)
    TreeFam Gene Tree for CXCR7 (if available) 

    Paralogs
    for CXCR7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCR7 gene
    RXFP32  BDKRB12  AGTR22  AGTR12  GPR252  APLNR2  GPR152  BDKRB22  
    GPR1822  RXFP42  
    18/38 SIMAP similar genes for CXCR7 using alignment to 1 protein entry:     CXCR7_HUMAN(see all similar genes):
    GPR182    gamrh    CXCR1    FPR3    FPRL2    GPR17
    CXCR2    IL8RB    SSTR1    AGTR1    CXCR4    CCR5
    CCR6    CCR7    CCRL1    BLR1    CCR1    CCR2

    CXCR7 for paralogs           About GeneDecksing



    Genomic Variants
    for CXCR7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 NCBI SNPs in CXCR7 are shown (see all 286)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1127661141,2
    		C,F--229278115(+) TGCGTT/GTCTGG 1 -- int16Minor allele frequency- G:0.13WA NA CSA 246
    rs1812677931,2
    		--237476390(+) CCGGCA/GGAACT 1 -- us2k10--------
    rs75877931,2
    		C,A--237476461(+) AGGCGT/CCTGGG 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1479477001,2
    		--237477295(+) GTGAAA/GCTTTT 1 -- us2k10--------
    rs1862559641,2
    		--237477343(+) CACACG/TGAGAC 1 -- us2k10--------
    rs286880141,2
    		--237477385(+) TCCCCC/GAGATT 1 -- us2k10--------
    rs772007511,2
    		F--237477431(+) TAGAAG/ATATAA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs341357991,2
    		C,F,H--237477514(+) CCGCTC/TTTTAA 1 -- us2k114Minor allele frequency- T:0.04NS EA NA 1420
    rs1427495951,2
    		--237477525(+) GAACTC/GCAGGA 1 -- us2k10--------
    rs729889001,2
    		C--237477627(+) ATGGGA/GCATTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CXCR7 (237476430 - 237491001 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CXCR7: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCR7
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCR7

    Disorders / Diseases
    for CXCR7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CXCR7 for disorders           About GeneDecksing

    OMIM gene information: 610376    OMIM disorders: --

    20 diseases for CXCR7:    About MalaCards
    lipoma    posterior polar cataract    immunodeficiency    myeloid malignancy
    gallbladder cancer    rheumatoid arthritis    cataract    rhabdomyosarcoma
    hepatocellular carcinoma    arthritis    breast carcinoma    lung cancer
    prostate cancer    sarcoma    pneumonia    carcinoma
    hypoxia    prostatitis    hepatitis    neuronitis

    2 Novoseek disease relationships for CXCR7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 9.59 2 16107333 (1), 10623723 (1)
    tumors 0 1 9510554 (1)

    Human Genome Epidemiology (HuGE) Navigator: CXCR7 (3 documents)

    Export disorders for CXCR7 gene to outside databases

    Publications
    for CXCR7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCR7 gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with CXCR7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. (PubMed id 16107333)1, 2, 3, 9 Balabanian K.... Bachelerie F. (2005)
    2. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. (PubMed id 16455976)1, 2, 9 Infantino S.... Thelen M. (2006)
    3. CXCR7 protein expression in human adult brain and differentiated neurons. (PubMed id 21655198)1, 2 Shimizu S.... Meucci O. (2011)
    4. CXCR7: a new SDF-1-binding receptor in contrast to no rmal CD34(+) progenitors is functional and is expressed at higher level in huma n malignant hematopoietic cells. (PubMed id 20887389)1, 2 Tarnowski M....Ratajczak M.Z. (2010)
    5. CXCR7 functions as a scavenger for CXCL12 and CXCL11. (PubMed id 20161793)1, 2 Naumann U....Thelen M. (2010)
    6. Beta-arrestin- but not G protein-mediated signaling b y the 'decoy' receptor CXCR7. (PubMed id 20018651)1, 2 Rajagopal S....Lefkowitz R.J. (2010)
    7. The chemokine receptor CXCR7 is highly expressed in h uman glioma cells and mediates antiapoptotic effects. (PubMed id 20388803)1, 2 Hattermann K....Mentlein R. (2010)
    8. Elucidation of CXCR7-mediated signaling events and in hibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligan ds. (PubMed id 19641136)1, 2 Zabel B.A....Schall T.J. (2009)
    9. A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. (PubMed id 18653785)1, 2 Hartmann T.N....Alon R. (2008)
    10. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. (PubMed id 16940167)1, 2 Burns J.M....Schall T.J. (2006)

    External Searches for CXCR7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CXCR7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57007 HGNC: 23692 AceView: CMKOR1 Ensembl:ENSG00000144476 euGenes: HUgn57007
    ECgene: CXCR7 Kegg: 57007 H-InvDB: CXCR7

    Other Databases showing CXCR7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXCR7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCR7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCR7 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXC_chemokine_receptors

    Intellectual Property
    for CXCR7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CXCR7 gene:
    Search GeneIP for patents involving CXCR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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