V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

CXCR7 Gene

protein-coding   GIFtS: 54

GC02P237143
chemokine (C-X-C motif) receptor 7
(Previous name: chemokine orphan receptor 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CMKOR1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
CMKOR1 2, 3, 5
CXC-R7 3
CXCR-7 3
GPR159 1, 2, 3, 5
RDC-1 3
RDC1 1, 2, 3, 5
Descriptions
Chemokine orphan receptor 1 1, 2, 3
G protein-coupled receptor 2
G-protein coupled receptor 159 3
G-protein coupled receptor RDC1 homolog 3
chemokine (C-X-C motif) receptor 7 2
External Ids
HGNC: 236921
Entrez Gene: 570072
UniProtKB: P251063
Ensembl: ENSG000001444767
Search outside databases for aliases for CXCR7 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CXCR7:
This gene encodes a member of the G-protein coupled receptor family. Although this protein was
earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to
be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also
a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and
HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq]

UniProtKB/Swiss-Prot: CXCR7_HUMAN, P25106
Function: Receptor for CXCL12/SDF1. Acts as coreceptor with CXCR4 for a restricted number of HIV
isolates

Gene Wiki entry for CXCR7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

CXCR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P237143:     (about GC identifiers)

Start:
237,143,119 bp from pter
End:
237,155,736 bp from pter
Size:
12,618 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_005120.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CXCR7_HUMAN, P25106 (See protein sequence)
Recommended Name: C-X-C chemokine receptor type 7  
Size: 362 amino acids; 41493 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: Was originally (PubMed:1675791) thought to be the receptor for VIP
Secondary accessions: Q53RV4 Q8NE10 Q92938 Q92986

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_064707.1  

    ENSEMBL proteins: 
    ENSP00000272928 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (GPCR RDC1)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane NAS--
    About this table

    Antibodies for CXCR7: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    R&D Systems Antibodies for CXCR7 (CXCR7/RDC-1)
    Antibodies from Abcam (GPCR RDC1), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for CXCR7

    Assays for CXCR7: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR001416 RDC1_rcpt
     IPR000276 7TM_GPCR_Rhodpsn


       GeneDecks  CXCR7 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P25106

    ProtoNet protein and cluster: P25106

    1 Blocks protein family: IPB001416 RDC1 orphan receptor signature

    UniProtKB/Swiss-Prot: CXCR7_HUMAN, P25106
    Similarity: Belongs to the G-protein coupled receptor 1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (CXCR7)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CMKOR1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001047841

                  Applied Biosystems Silencer® siRNAs for CXCR7

                  Sigma-Aldrich siRNA and siRNA Panels for CXCR7  
                         Sigma-Aldrich shRNA Panels and shRNA for CXCR7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for CXCR7
    Millipore Clones for the Expression of CXCR7
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_020311
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_020311
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001047841 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001047841

    UniProtKB/Swiss-Prot: CXCR7_HUMAN, P25106
    Function: Receptor for CXCL12/SDF1. Acts as coreceptor with CXCR4 for a restricted number of HIV
    isolates

    7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cxcr7):

    digestive/alimentaryhematopoietic systemimmune systemlethality-prenatal/perinatal
    life span-post-weaning/agingnervous system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity IEA--
    GO:0005515 protein binding IPI17474147
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for CXCR7
     Selected targets of CREB1

       GeneDecks  CXCR7 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  CXCR7 


    5/6 Interacting proteins for CXCR7 (ENSP000002729283 P251061) via UniProtKB, MINT, and/or STRING (see all 6 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931EBI-1965291, EBI-401755
    CXCL12ENSP000003635483STRING (score=.998)
    CXCL11ENSP000003068843STRING (score=.953)
    CXCR4ENSP000002413933STRING (score=.914)
    CCL21ENSP000002596073STRING (score=.789)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction IEA--
    GO:0007186 G-protein coupled receptor protein signaling pathway IEA--
    GO:0008150 biological_process ND--
    GO:0044419 interspecies interaction between organisms IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Compounds for CXCR7 available from Tocris Bioscience

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (CXCR7)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CMKOR1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001047841

                  Sigma-Aldrich siRNA and siRNA Panels for CXCR7  
                         Sigma-Aldrich shRNA Panels and shRNA for CXCR7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_020311  

    REFSEQ mRNAs for CXCR7 gene: 

    NM_020311.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_020311  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_020311
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_020311
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001047841 

    Additional cDNA sequence: 

    AF030297.1 AK023507.1 AK291659.1 BC008459.1 BC036661.2 BC038720.1 CR616388.1 DQ822477.1 
    M64749.1 U67784.1 

    10 DOTS entries:

    DT.95270731  DT.456342  DT.65288284  DT.100673506  DT.100809392  DT.92422019  DT.121001874  DT.100809387 
    DT.92064866  DT.92422024 

    24/144 AceView cDNA sequences (see all 144 ):

    AI364791 AI147203 BF475500 BC008459 BQ889219 AL543359 AI375869 BM712288 
    AI954295 BM722609 AW771079 BF926353 NM_020311 AA197246 AW316612 BX483000 
    BX110394 BM804836 AA905072 AI492871 AL540325 BE552368 AK023507 CR616388 

    highest scoring ESTs for CXCR7:

    AA057666 AA313086 AA331167 AA341595 AA369066 AA905072 AA912155 AA927383 AI147203 AI224103 

    Unigene Cluster for CXCR7:

    Chemokine (C-X-C motif) receptor 7
    Hs.471751  [show with all ESTs]
    Unigene Representative Sequence: BC036661


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000272928  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CXCR7 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for CXCR7

    1 / 2 / 3

    6 probe-sets matching CXCR7 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    34288_at2, 3 U95-A 1 1.00 1.00 0.92 1.38 U67784 0.80 1.00 0.91 1

    72739_at*2, 3 U95-E 1 1.00 1.00 0.57 0.64 AI620820 0.60 1.00 0.82 1

    212977_at2, 3 U133-A 1 1.00 1.00 -- -- AI817041 0.80 1.00 0.91 1

    232746_at*2, 3 U133-B 1 1.00 1.00 -- -- BE552368 0.40 1.00 0.76 1

    212977_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    232746_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  CXCR7 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCACACAGTG

    SOURCE GeneReport for Unigene cluster: Hs.471751

    UniProtKB/Swiss-Prot: CXCR7_HUMAN, P25106
    Tissue specificity: Expressed in monocytes, basophils, and B-cells. Lower expression in CD4+
    T-lymphocytes and natural killer cells

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for CXCR7 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    CXCR71   -- chemokine (C-X-C motif) receptor 7 90.33(n)
    93.37(a)
    403964  NM_001003281.1  NP_001003281.1 
    chimpanzee
    (Pan troglodytes)
    CXCR71   -- chemokine (C-X-C motif) receptor 7 99.26(n)
    99.72(a)
    460122  XM_001152625.1  XP_001152625.1 
    cow
    (Bos taurus)
    CXCR71   -- chemokine (C-X-C motif) receptor 7 89.04(n)
    88.95(a)
    509585  XM_586581.3  XP_586581.2 
    rat
    (Rattus norvegicus)
    Cxcr71   -- chemokine (C-X-C motif) receptor 7 89.13(n)
    92.54(a)
    84348  NM_053352.1  NP_445804.1 
    mouse
    (Mus musculus)
    Cxcr71, 5 1 (55.60 cM)5
    chemokine (C-X-C motif) receptor 71, 5 88.67(n)1
    92.82(a)1
    127781  NM_007722.31  NP_031748.21 
     AF0002365  AK0311005  (see all 8)
    About this table        Species with no ortholog for CXCR7

    ENSEMBL Gene Tree for CXCR7
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for CXCR7 gene
    GPR252  GPR152  GPR1822  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

      --
    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610376

    2 Novoseek disease relationships for CXCR7 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 10.29 2 16107333 (1), 10623723 (1)
    tumors 0.00 1 9510554 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/29 PubMed articles for CXCR7 gene (see all 29 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 57007 HGNC: 23692 AceView: CMKOR1 Ensembl:ENSG00000144476 euGenes: HUgn57007
    ECgene: CXCR7 H-InvDB: CXCR7
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for CXCR7 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CXCR7:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for CXCR7-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for CXCR7 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CXCR7 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Search for Antibodies
     Chimera RNAi (CMKOR1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (GPCR RDC1)
     Antibodies (GPCR RDC1)
     Search OriGene for CXCR7
     Tocris compounds for CXCR7




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for CXCR7

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    CXCR7 Gene at Home site.
    Version 2.41.1
    server4.xennexinc.com