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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCR6 Gene

protein-coding   GIFtS: 60
GCID: GC03P045982

chemokine (C-X-C motif) receptor 6

 Explore 38 diseases affiliated with
CXCR6 via our new
 Human Malady Compendium 
Biological research products
for CXCR6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Receptor 61 2     CXCR-62 3
BONZO1 2 3 5     G-Protein Coupled Receptor Bonzo2 3
STRL331 2 3 5     G-Protein Coupled Receptor STRL332 3
TYMSTR1 2 3     C-X-C Chemokine Receptor Type 62
CD1861 2     G Protein-Coupled Receptor2
CDw1862 3     CD186 Antigen3
CXC-R62 3     

External Ids:    HGNC: 166471   Entrez Gene: 106632   Ensembl: ENSG000001722157   OMIM: 6051635   UniProtKB: O005743   

Export aliases for CXCR6 gene to outside databases

Previous GC identifers: GC03P045225 GC03P045804 GC03P045945 GC03P045959


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CXCR6_HUMAN, O00574
Function: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic
HIV-1

Gene Wiki entry for CXCR6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCR6 gene promoter:
         HFH-3   AML1a   ATF-2   E4BP4   HNF-1A   RORalpha1   FOXI1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCR6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCR6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CXCR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCR6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P045982:  view genomic region     (about GC identifiers)

Start:
45,982,425 bp from pter      End:
45,989,845 bp from pter
Size:
7,421 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CXCR6_HUMAN, O00574 (See protein sequence)
Recommended Name: C-X-C chemokine receptor type 6  
Size: 342 amino acids; 39280 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O00575 Q9HCA5

Explore the universe of human proteins at neXtProt for CXCR6: NX_O00574

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00574

  • CXCR6 Protein expression data from MOPED and PaxDb:    About this image 
    CXCR6 Protein Expression
    REFSEQ proteins: NP_006555.1  
    ENSEMBL proteins: 
     ENSP00000396218   ENSP00000304414   ENSP00000395704   ENSP00000396886  
    Reactome Protein details: O00574
    Human Recombinant Protein Products for CXCR6: 
    EMD Millipore Purified and/or Recombinant CXCR6 Protein
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    OriGene Protein Over-expression Lysate: CXCR6
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    Novus Biologicals CXCR6 Proteins
    Novus Biologicals CXCR6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CXCR6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9166430

    CXCR6 for ontologies           About GeneDecksing



    CXCR6 Antibody Products: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CXCR6


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CXCR6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002235 Chemokine_CXCR6
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O00574

    ProtoNet protein and cluster: O00574

    2 Blocks protein families:
    IPB000355 Chemokine receptor signature
    IPB002235 GPCR Bonzo signature


    UniProtKB/Swiss-Prot: CXCR6_HUMAN, O00574
    Similarity: Belongs to the G-protein coupled receptor 1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCR6_HUMAN, O00574
    Function: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic
    HIV-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS9166430
    GO:0015026coreceptor activity TAS9166430
    GO:0016494C-X-C chemokine receptor activity IEA--
         
    CXCR6 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CXCR6:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cxcr6):
     normal  reproductive system  tumorigenesis 

    CXCR6 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Cxcr6tm1Lex for CXCR6
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CXCR6 

    miRNA
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    OriGene 3'-UTR Clone: CXCR6
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCR6
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCR6:
    hsa-miR-4310 hsa-miR-1252 hsa-miR-1179
    SwitchGear 3'UTR luciferase reporter plasmidCXCR6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCR6 (see all 7)
    OriGene shRNA RFP: CXCR6
    OriGene siRNA: CXCR6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCR6
    Sirion Biotech Custom design and validation of potent shRNA sequences against CXCR6 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CXCR6 
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR6 

    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for CXCR6

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)1.00
    Peptide ligand-binding receptors0.61
    GPCR ligand binding0.75
    G alpha (i) signalling events0.44
    2Akt Signaling
    Akt Signaling1.00
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    3Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    Peptide GPCRs0.46
    5Chemokine Signaling
    Chemokine Signaling1.00
    Chemokine signaling pathway0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CXCR6
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCR6 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    1 BioSystems Pathway for CXCR6 
        Peptide GPCRs

    5/8        Reactome Pathways for CXCR6 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    2         Kegg Pathways  (Kegg details for CXCR6):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CXCR6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCR6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/182 Interacting proteins for CXCR6 (O005743 ENSP000003044144) via UniProtKB, MINT, STRING, and/or I2D (see all 182)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCL16Q9H2A73, ENSP000002937784I2D: score=1 STRING: ENSP00000293778
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADORA3ENSP000003587304STRING: ENSP00000358730
    APLNRENSP000002572544STRING: ENSP00000257254
    C3AR1ENSP000003020794STRING: ENSP00000302079
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9166430
    GO:0019079viral genome replication TAS9230441

    CXCR6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCR6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCR6
    3 Novoseek chemical compound relationships for CXCR6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 45.1 3 16999022 (1), 11138769 (1), 15992849 (1)
    ionomycin 18.1 2 12914753 (2)
    calcium 0 1 12928408 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCR6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CXCR6 gene: 
    NM_006564.1  

    Unigene Cluster for CXCR6:

    Chemokine (C-X-C motif) receptor 6
    Hs.34526  [show with all ESTs]
    Unigene Representative Sequence: U73531
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000438735 ENST00000304552(uc003cpc.1 uc010hix.1) ENST00000458629(uc021www.1)
    ENST00000457814

    miRNA
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    OriGene 3'-UTR Clone: CXCR6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCR6
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCR6:
    hsa-miR-4310 hsa-miR-1252 hsa-miR-1179
    SwitchGear 3'UTR luciferase reporter plasmidCXCR6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCR6 (see all 7)
    OriGene shRNA RFP: CXCR6
    OriGene siRNA: CXCR6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCR6
    Sirion Biotech Custom design and validation of potent shRNA sequences against CXCR6 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCR6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCR6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CXCR6 (NM_006564)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR6 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCR6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCR6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCR6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCR6

    Additional cDNA sequence: 

    AF007545.1 AK313754.1 BC033584.1 U73529.1 U73531.1 Y13248.1 

    4 DOTS entries:

    DT.100657227  DT.312306  DT.91751228  DT.120856935 

    24/29 AceView cDNA sequences (see all 29):

    BX398107 BX398345 Y13248 U73529 CR624554 NM_006564 BX110105 AF007545 
    CR601642 AA044602 BQ010576 U73531 U73530 BC033584 BX399772 R91916 
    AA876343 AA702346 BM919012 BM543622 AA977724 AA703025 AI559967 BG113134 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCR6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAATGCTTGA
    CXCR6 Expression
    About this image
    See CXCR6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCR6

    SOURCE GeneReport for Unigene cluster: Hs.34526

    UniProtKB/Swiss-Prot: CXCR6_HUMAN, O00574
    Tissue specificity: Expressed in lymphoid tissues and activated T cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCR6: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CXCR6 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia CXCR66
    --
    47(a)
    1 ↔ 1
    GL343324.1(306530-307567)
    zebrafish
    (Danio rerio)
    Actinopterygii ccr9a6
    CU151878.16
    (see all 3)
    --
    33(a)
    31(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(32514748-32516958)
    24(12219123-12226643)


    ENSEMBL Gene Tree for CXCR6 (if available)
    TreeFam Gene Tree for CXCR6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCR6 gene
    CCR62  CCR52  CXCR32  XCR12  CCR92  CCBP22  CCRL22  CCR72  
    CCR82  CX3CR12  CXCR22  CCRL12  CCR42  CXCR12  CCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/33 SIMAP similar genes for CXCR6 using alignment to 2 protein entries:     CXCR6_HUMAN (see all proteins) (see all similar genes):
    CCR7    CCR2    CCR9    CCR4    CCR5    CXCR4
    AGTR1    CCR10    CXCR2    IL8RB    CCBP2    CCR1
    CCR3    CCR8    CCRL1    CX3CR1    CXCR1    SSTR4

    CXCR6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/133 NCBI SNPs in CXCR6 are shown (see all 133    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1885634331,2
    --45983011(+) GCAGAC/TAGTAA 2 -- int1 us2k10--------
    rs1807064481,2
    --45983028(+) TTTTGG/TAAAGT 2 -- int1 us2k10--------
    rs1429945261,2
    --45983060(+) CCAAAC/GCTGCA 2 -- int1 us2k10--------
    rs1474672151,2
    --45983092(+) TAGGTG/TAAAGT 2 -- int1 us2k10--------
    rs1851420411,2
    --45983245(+) GAAAGA/GCTTGC 2 -- int1 us2k10--------
    rs1918704891,2
    --45983416(+) CCTGCC/TTTGAA 2 -- int1 us2k10--------
    rs37746401,2
    C,F--45983479(-) GTGGAC/TAAATG 2 -- us2k1 int118Minor allele frequency- T:0.32EA NA NS WA CSA 2174
    rs1401723251,2
    --45983523(+) GTCTAC/TGCGGC 2 -- int1 us2k10--------
    rs1420223651,2
    --45983651(+) TTATCA/CGGGCC 2 -- int1 us2k10--------
    rs37746391,2
    C,F,A,H--45983654(-) GGGGGC/TCCTGA 2 -- int1 us2k122Minor allele frequency- T:0.34NS EA NA WA 2524

    HapMap Linkage Disequilibrium report for CXCR6 (45982425 - 45989845 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CXCR6: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCR6
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCR6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CXCR6 for disorders           About GeneDecksing

    OMIM gene information: 605163    OMIM disorders: --

    20/38 diseases for CXCR6 (see all 38):    About MalaCards
    xanthogranulomatous cholecystitis    hiv-1, resistance to    chronic obstructive pulmonary disease    malt lymphoma
    pancreatic ductal adenocarcinoma    coronary heart disease    sarcoidosis    rheumatoid arthritis
    hepatitis c    pulmonary sarcoidosis    cholecystitis    pulmonary disease
    graves' disease    prostate cancer, progression of    periodontitis    periodontal disease
    osteosarcoma    nephropathy    arthritis    prostate cancer

    10/12 Novoseek disease relationships for CXCR6 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 51.1 7 10799581 (2), 9765485 (1), 9791028 (1), 11878872 (1) (see all 5)
    necrosis 22.9 2 19438592 (1), 18778363 (1)
    sarcoidosis 20 5 16100013 (3), 17615381 (1), 16393323 (1)
    atherosclerosis 19.4 1 16870145 (1)
    inflammation 17.7 2 12914753 (1), 19690611 (1)
    virus infection 11.4 1 10891428 (1)
    liver diseases 10.4 1 15634930 (1)
    metastasis 9.45 4 16955398 (2), 17306330 (1), 19231068 (1)
    tumors 7.84 4 19074906 (2), 18452560 (1), 18636150 (1)
    osteosarcoma 5.2 1 11878871 (1)

    Genetic Association Database (GAD): CXCR6
    Human Genome Epidemiology (HuGE) Navigator: CXCR6 (7 documents)

    Export disorders for CXCR6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCR6 gene, integrated from 9 sources (see all 141):
    (articles sorted by number of sources associating them with CXCR6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV- 1. (PubMed id 9166430)1, 2, 3, 9 Liao F....Farber J.M. (1997)
    2. Expression cloning of new receptors used by simian and human immunodeficiency viruses. (PubMed id 9230441)1, 2, 3 Deng H.K.... Littman D.R. (1997)
    3. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. (PubMed id 9285716)1, 2, 9 Loetscher M.... Moser B. (1997)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans. (PubMed id 12761559)1, 4 Duggal P....Winkler C.A. (2003)
    6. Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin. (PubMed id 12914753)1, 9 Koprak S....Dumont F.J. (2003)
    7. Chemokine C-X-C motif receptor 6 contributes to cell migration during hypoxia. (PubMed id 19231068)1, 9 Lin S....Zhang L. (2009)
    8. CXCR6 within T-helper (Th) and T-cytotoxic (Tc) type 1 lymphocytes in Graves' disease (GD). (PubMed id 15817921)1, 9 Aust G....Schmucking E. (2005)
    9. TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells. (PubMed id 16870145)1, 9 Patel D.N....Chandrasekar B. (2006)
    10. Expression of chemokine receptor CXCR6 in human colorectal adenocarcinomas. (PubMed id 15736401)1, 9 Wagsater D. and Dimberg J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10663 HGNC: 16647 AceView: CXCR6 Ensembl:ENSG00000172215 euGenes: HUgn10663
    ECgene: CXCR6 Kegg: 10663 H-InvDB: CXCR6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCR6 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXCR6 gene:
    Search GeneIP for patents involving CXCR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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