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Aliases for CXCR6 Gene

Aliases for CXCR6 Gene

  • C-X-C Motif Chemokine Receptor 6 2 3
  • Chemokine (C-X-C Motif) Receptor 6 2 3 5
  • G-Protein Coupled Receptor STRL33 3 4
  • G-Protein Coupled Receptor Bonzo 3 4
  • CDw186 3 4
  • CXC-R6 3 4
  • CXCR-6 3 4
  • STRL33 3 4
  • TYMSTR 3 4
  • BONZO 3 4
  • G Protein-Coupled Receptor 3
  • CD186 Antigen 4
  • CD186 3

External Ids for CXCR6 Gene

Previous GeneCards Identifiers for CXCR6 Gene

  • GC03P045225
  • GC03P045804
  • GC03P045945
  • GC03P045959

Summaries for CXCR6 Gene

GeneCards Summary for CXCR6 Gene

CXCR6 (C-X-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CXCR6 include Xanthogranulomatous Cholecystitis. Among its related pathways are Peptide ligand-binding receptors and ERK Signaling. GO annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for CXCR6 Gene

  • Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Gene Wiki entry for CXCR6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR6 Gene

Genomics for CXCR6 Gene

Regulatory Elements for CXCR6 Gene

Enhancers for CXCR6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CXCR6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCR6 Gene

45,940,399 bp from pter
45,948,354 bp from pter
7,956 bases
Plus strand

Genomic View for CXCR6 Gene

Genes around CXCR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR6 Gene

Proteins for CXCR6 Gene

  • Protein details for CXCR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-X-C chemokine receptor type 6
    Protein Accession:
    Secondary Accessions:
    • O00575
    • Q9HCA5

    Protein attributes for CXCR6 Gene

    342 amino acids
    Molecular mass:
    39280 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCR6 Gene

Proteomics data for CXCR6 Gene at MOPED

Post-translational modifications for CXCR6 Gene

  • Glycosylation at Asn 16
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR6 Gene

Antibody Products

No data available for DME Specific Peptides for CXCR6 Gene

Domains & Families for CXCR6 Gene

Gene Families for CXCR6 Gene

Suggested Antigen Peptide Sequences for CXCR6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR6: view

Function for CXCR6 Gene

Molecular function for CXCR6 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
genes like me logo Genes that share phenotypes with CXCR6: view

Animal Models for CXCR6 Gene

MGI Knock Outs for CXCR6:

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCR6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCR6 Gene

Localization for CXCR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CXCR6 Gene COMPARTMENTS Subcellular localization image for CXCR6 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CXCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CXCR6: view

Pathways & Interactions for CXCR6 Gene

genes like me logo Genes that share pathways with CXCR6: view

Gene Ontology (GO) - Biological Process for CXCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with CXCR6: view

No data available for SIGNOR curated interactions for CXCR6 Gene

Drugs & Compounds for CXCR6 Gene

(5) Drugs for CXCR6 Gene - From: ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CXCL16 Pharma Full agonist, Agonist 0
Plerixafor 8HCl (AMD3100 8HCl) Pharma CXCR4 antagonist 0
WZ811 Pharma Competitive CXR4 antagonist,highly potent 0
[<SUP>125</SUP>I]CXCL16 (HUMAN) Pharma 0

(3) Additional Compounds for CXCR6 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist

(2) ApexBio Compounds for CXCR6 Gene

Compound Action Cas Number
Plerixafor 8HCl (AMD3100 8HCl) CXCR4 antagonist 155148-31-5
WZ811 Competitive CXR4 antagonist,highly potent 55778-02-4
genes like me logo Genes that share compounds with CXCR6: view

Transcripts for CXCR6 Gene

Unigene Clusters for CXCR6 Gene

Chemokine (C-X-C motif) receptor 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR6 Gene

No ASD Table

Relevant External Links for CXCR6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXCR6 Gene

mRNA expression in normal human tissues for CXCR6 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR6 Gene

This gene is overexpressed in Spleen (x8.9), Muscle - Skeletal (x5.6), Whole Blood (x5.3), and Small Intestine - Terminal Ileum (x4.4).

SOURCE GeneReport for Unigene cluster for CXCR6 Gene Hs.34526

mRNA Expression by UniProt/SwissProt for CXCR6 Gene

Tissue specificity: Expressed in lymphoid tissues and activated T cells.
genes like me logo Genes that share expression patterns with CXCR6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CXCR6 Gene

Orthologs for CXCR6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CXCR6 35
  • 82.25 (n)
  • 79.71 (a)
CXCR6 36
  • 81 (a)
(Canis familiaris)
Mammalia CXCR6 35
  • 84.75 (n)
  • 81.82 (a)
CXCR6 36
  • 82 (a)
(Mus musculus)
Mammalia Cxcr6 35
  • 79.18 (n)
  • 75.66 (a)
Cxcr6 16
Cxcr6 36
  • 73 (a)
(Pan troglodytes)
Mammalia CXCR6 35
  • 99.81 (n)
  • 99.42 (a)
CXCR6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cxcr6 35
  • 78.04 (n)
  • 73.82 (a)
(Monodelphis domestica)
Mammalia CXCR6 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia CXCR6 36
  • 53 (a)
(Anolis carolinensis)
Reptilia CXCR6 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cxcr6 35
  • 55.63 (n)
  • 46.37 (a)
Species with no ortholog for CXCR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCR6 Gene

Gene Tree for CXCR6 (if available)
Gene Tree for CXCR6 (if available)

Paralogs for CXCR6 Gene

genes like me logo Genes that share paralogs with CXCR6: view

Variants for CXCR6 Gene

Sequence variations from dbSNP and Humsavar for CXCR6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_003506 -
VAR_024253 -

Structural Variations from Database of Genomic Variants (DGV) for CXCR6 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294
nsv834678 CNV Gain 17160897
nsv876736 CNV Gain 21882294

Variation tolerance for CXCR6 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CXCR6 Gene

Disorders for CXCR6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXCR6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
xanthogranulomatous cholecystitis
  • cx
- elite association - COSMIC cancer census association via MalaCards
Search CXCR6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCR6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CXCR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR6 Gene

Publications for CXCR6 Gene

  1. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV- 1. (PMID: 9166430) Liao F. … Farber J.M. (J. Exp. Med. 1997) 2 3 4 23 67
  2. Chemokine C-X-C motif receptor 6 contributes to cell migration during hypoxia. (PMID: 19231068) Lin S. … Zhang L. (Cancer Lett. 2009) 3 23
  3. The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. (PMID: 19690611) Darash-Yahana M. … Farber J.M. (PLoS ONE 2009) 3 23
  4. Homocysteine up-regulates vascular transmembrane chemokine CXCL16 and induces CXCR6+ lymphocyte recruitment in vitro and in vivo. (PMID: 18194461) Postea O. … Ludwig A. (J. Cell. Mol. Med. 2008) 3 23
  5. Human trophoblasts recruited T lymphocytes and monocytes into decidua by secretion of chemokine CXCL16 and interaction with CXCR6 in the first-trimester pregnancy. (PMID: 18250446) Huang Y. … Li D.J. (J. Immunol. 2008) 3 23

Products for CXCR6 Gene

Sources for CXCR6 Gene