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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCR6 Gene

protein-coding   GIFtS: 61
GCID: GC03P045982

Chemokine (C-X-C Motif) Receptor 6

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Receptor 61 2     G-Protein Coupled Receptor Bonzo2 3
BONZO2 3 5     G-Protein Coupled Receptor STRL332 3
STRL332 3 5     CD1862
CDw1862 3     C-X-C Chemokine Receptor Type 62
CXC-R62 3     G Protein-Coupled Receptor2
CXCR-62 3     CD186 Antigen3
TYMSTR2 3     

External Ids:    HGNC: 166471   Entrez Gene: 106632   Ensembl: ENSG000001722157   OMIM: 6051635   UniProtKB: O005743   

Export aliases for CXCR6 gene to outside databases

Previous GC identifers: GC03P045225 GC03P045804 GC03P045945 GC03P045959


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CXCR6 Gene: 
CXCR6 (chemokine (C-X-C motif) receptor 6) is a protein-coding gene. Diseases associated with CXCR6 include xanthogranulomatous cholecystitis, and cholecystitis, and among its related super-pathways are Peptide GPCRs and STAT3 Pathway. GO annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CCR6.

UniProtKB/Swiss-Prot: CXCR6_HUMAN, O00574
Function: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and
m-tropic HIV-1

Gene Wiki entry for CXCR6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCR6 gene promoter:
         HFH-3   AML1a   ATF-2   E4BP4   HNF-1A   RORalpha1   FOXI1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCR6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCR6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CXCR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCR6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P045982:  view genomic region     (about GC identifiers)

Start:
45,982,425 bp from pter      End:
45,989,845 bp from pter
Size:
7,421 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXCR6_HUMAN, O00574 (See protein sequence)
Recommended Name: C-X-C chemokine receptor type 6  
Size: 342 amino acids; 39280 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O00575 Q9HCA5

Explore the universe of human proteins at neXtProt for CXCR6: NX_O00574

Explore proteomics data for CXCR6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00574

  • CXCR6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXCR6 Protein Expression
    REFSEQ proteins: NP_006555.1  
    ENSEMBL proteins: 
     ENSP00000396218   ENSP00000304414   ENSP00000395704   ENSP00000396886  
    Reactome Protein details: O00574
    Human Recombinant Protein Products for CXCR6: 
    EMD Millipore Purified and/or Recombinant CXCR6 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CXCR6
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CXCR6
    GenScript Custom Purified and Recombinant Proteins Services for CXCR6
    Novus Biologicals CXCR6 Proteins
    Novus Biologicals CXCR6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CXCR6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9166430
    GO:0016021integral to membrane ----

    CXCR6 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for CXCR6
    LSBio Antibodies in human, mouse, rat for CXCR6 

    Assay Products for CXCR6: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CXCR6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CXCR6 
    Cloud-Clone Corp. CLIAs for CXCR6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    CXCR: GPCR / Class A : Chemokine receptors : C-X-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CXCR6 
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002235 Chemokine_CXCR6
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O00574

    ProtoNet protein and cluster: O00574

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB002235 GPCR Bonzo signature


    UniProtKB/Swiss-Prot: CXCR6_HUMAN, O00574
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CXCR6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCR6_HUMAN, O00574
    Function: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and
    m-tropic HIV-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS9166430
    GO:0015026coreceptor activity IEA--
    GO:0016464chloroplast protein-transporting ATPase activity ----
    GO:0016493C-C chemokine receptor activity IEA--
    GO:0016494C-X-C chemokine receptor activity IEA--
         
    CXCR6 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CXCR6:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cxcr6):
     normal  reproductive system  tumorigenesis 

    CXCR6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cxcr6tm1Lex for CXCR6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCR6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCR6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCR6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCR6 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCR6
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCR6:
    hsa-miR-4310 hsa-miR-1252 hsa-miR-1179
    SwitchGear 3'UTR luciferase reporter plasmidCXCR6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CXCR6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCR6

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CXCR6

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CXCR6 (see all 7)
    OriGene ORF clones in mouse, rat for CXCR6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXCR6 (NM_006564)
    Sino Biological Human cDNA Clone for CXCR6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR6
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                         Customized lentivirus expression plasmids for stable overexpression of CXCR6 

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    Search LifeMap BioReagents cell lines for CXCR6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CXCR6 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CXCR6
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCR6 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    1 BioSystems Pathway for CXCR6
        Peptide GPCRs


    5/8        Reactome Pathways for CXCR6 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    2         Kegg Pathways  (Kegg details for CXCR6):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CXCR6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCR6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/182 Interacting proteins for CXCR6 (O005743 ENSP000003044144) via UniProtKB, MINT, STRING, and/or I2D (see all 182)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCL16Q9H2A73, ENSP000002937784I2D: score=1 STRING: ENSP00000293778
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADORA3ENSP000003587304STRING: ENSP00000358730
    APLNRENSP000002572544STRING: ENSP00000257254
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS9166430
    GO:0007204elevation of cytosolic calcium ion concentration ----

    CXCR6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCR6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCR6

    2 IUPHAR Ligands for CXCR6 (CXCR6)    About this table 
    LigandTypeActionAffinityPubmed IDs
    CXCL16
    AgonistFull agonist911290797
    [125I]CXCL16
    AgonistFull agonist9--

    3 Novoseek inferred chemical compound relationships for CXCR6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 45.1 3 16999022 (1), 11138769 (1), 15992849 (1)
    ionomycin 18.1 2 12914753 (2)
    calcium 0 1 12928408 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCR6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CXCR6 gene: 
    NM_006564.1  

    Unigene Cluster for CXCR6:

    Chemokine (C-X-C motif) receptor 6
    Hs.34526  [show with all ESTs]
    Unigene Representative Sequence: U73531
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000438735 ENST00000304552(uc003cpc.1 uc010hix.1) ENST00000458629(uc021www.1)
    ENST00000457814
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCR6
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCR6:
    hsa-miR-4310 hsa-miR-1252 hsa-miR-1179
    SwitchGear 3'UTR luciferase reporter plasmidCXCR6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CXCR6 (NM_006564)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR6
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                         Customized lentivirus expression plasmids for stable overexpression of CXCR6 
    Primer
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    OriGene qPCR primer pairs and template standards for CXCR6
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCR6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCR6

    Additional mRNA sequence: 

    AF007545.1 AK313754.1 BC033584.1 U73529.1 U73531.1 Y13248.1 

    4 DOTS entries:

    DT.100657227  DT.312306  DT.91751228  DT.120856935 

    24/29 AceView cDNA sequences (see all 29):

    NM_006564 Y13248 BX398107 AF007545 BX110105 CR601642 BX398345 U73529 
    CR624554 AA044602 U73530 BC033584 BQ010576 R91916 BX399772 U73531 
    AA702346 BM543622 AA977724 AA876343 BM919012 AA703025 AI559967 BG113134 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCR6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATGCTTGA
    CXCR6 Expression
    About this image


    See CXCR6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCR6

    SOURCE GeneReport for Unigene cluster: Hs.34526

    UniProtKB/Swiss-Prot: CXCR6_HUMAN, O00574
    Tissue specificity: Expressed in lymphoid tissues and activated T cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCR6: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCR6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CXCR6 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcr61 , 5 chemokine (C-X-C motif) receptor 61, 5 79.18(n)1
    75.66(a)1
      9 (74.57 cM)5
    809011  NM_030712.41  NP_109637.31 
     1238064775 
    lizard
    (Anolis carolinensis)
    Reptilia CXCR66
    Uncharacterized protein
    47(a)
    1 ↔ 1
    GL343324.1(306530-307567)


    ENSEMBL Gene Tree for CXCR6 (if available)
    TreeFam Gene Tree for CXCR6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCR6 gene
    CCR62  CCR52  ACKR42  CXCR32  XCR12  CCR92  CCRL22  CCR72  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/33 SIMAP similar genes for CXCR6 using alignment to 2 protein entries:     CXCR6_HUMAN (see all proteins) (see all similar genes):
    CCR7    CCR2    CCR9    CCR4    CCR5    CXCR4
    AGTR1    CCR10    CXCR2    IL8RB    CCBP2    CCR1
    CCR3    CCR8    CCRL1    CX3CR1    CXCR1    SSTR4

    CXCR6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in CXCR6 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0242534
    ----see VAR_0242532 E K mis40--------
    VAR_0035064
    ----see VAR_0035062 D A mis40--------

    HapMap Linkage Disequilibrium report for CXCR6 (45982425 - 45989845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CXCR6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834678CNV Gain17160897
    nsv876734CNV Gain21882294
    nsv876736CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCR6
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCR6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605163    OMIM disorders: --

    20/36 diseases for CXCR6 (see all 36):    About MalaCards
    xanthogranulomatous cholecystitis    cholecystitis    hiv type 1    pulmonary sarcoidosis
    hiv-1, resistance to    pancreatic ductal adenocarcinoma    sarcoidosis    malt lymphoma
    prostate cancer, progression of    osteosarcoma    chronic obstructive pulmonary disease    periodontal disease
    graves' disease    hepatitis c    gingivitis    periodontitis
    atherosclerosis    nasopharyngitis    coronary heart disease    rheumatoid arthritis


    CXCR6 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for CXCR6 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 51.1 7 10799581 (2), 9765485 (1), 9791028 (1), 11878872 (1) (see all 5)
    necrosis 22.9 2 19438592 (1), 18778363 (1)
    sarcoidosis 20 5 16100013 (3), 17615381 (1), 16393323 (1)
    atherosclerosis 19.4 1 16870145 (1)
    inflammation 17.7 2 12914753 (1), 19690611 (1)
    virus infection 11.4 1 10891428 (1)
    liver diseases 10.4 1 15634930 (1)
    metastasis 9.45 4 16955398 (2), 17306330 (1), 19231068 (1)
    tumors 7.84 4 19074906 (2), 18452560 (1), 18636150 (1)
    osteosarcoma 5.2 1 11878871 (1)

    Genetic Association Database (GAD): CXCR6
    Human Genome Epidemiology (HuGE) Navigator: CXCR6 (7 documents)

    Export disorders for CXCR6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCR6 gene, integrated from 9 sources (see all 144):
    (articles sorted by number of sources associating them with CXCR6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV- 1. (PubMed id 9166430)1, 2, 3, 9 Liao F....Farber J.M. (1997)
    2. Expression cloning of new receptors used by simian and human immunodeficiency viruses. (PubMed id 9230441)1, 2, 3 Deng H.K.... Littman D.R. (1997)
    3. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. (PubMed id 9285716)1, 2, 9 Loetscher M.... Moser B. (1997)
    4. Multiple-cohort genetic association study reveals CXC R6 as a new chemokine receptor involved in long-term nonprogression to AIDS. (PubMed id 20704485)1, 4 Limou S....Zagury J.F. (2010)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    6. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    7. Polymorphisms of Cx(3)CR1 and CXCR6 receptors in relation to HAART therapy of HIV type 1 patients. (PubMed id 17725420)1, 4 Passam A.M....Spandidos D.A. (2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans. (PubMed id 12761559)1, 4 Duggal P....Winkler C.A. (2003)
    10. Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin. (PubMed id 12914753)1, 9 Koprak S....Dumont F.J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10663 HGNC: 16647 AceView: CXCR6 Ensembl:ENSG00000172215 euGenes: HUgn10663
    ECgene: CXCR6 Kegg: 10663 H-InvDB: CXCR6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCR6 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXCR6 gene:
    Search GeneIP for patents involving CXCR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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