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Aliases for CXCR6 Gene

Aliases for CXCR6 Gene

  • C-X-C Motif Chemokine Receptor 6 2 3 5
  • Chemokine (C-X-C Motif) Receptor 6 2 3
  • G-Protein Coupled Receptor STRL33 3 4
  • G-Protein Coupled Receptor Bonzo 3 4
  • CDw186 3 4
  • CXC-R6 3 4
  • CXCR-6 3 4
  • STRL33 3 4
  • TYMSTR 3 4
  • BONZO 3 4
  • C-X-C Chemokine Receptor Type 6 3
  • G Protein-Coupled Receptor 3
  • CD186 Antigen 4
  • CD186 3

External Ids for CXCR6 Gene

Previous GeneCards Identifiers for CXCR6 Gene

  • GC03P045225
  • GC03P045804
  • GC03P045945
  • GC03P045959

Summaries for CXCR6 Gene

GeneCards Summary for CXCR6 Gene

CXCR6 (C-X-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CXCR6 include Xanthogranulomatous Cholecystitis. Among its related pathways are Peptide ligand-binding receptors and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. GO annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CCR6.

UniProtKB/Swiss-Prot for CXCR6 Gene

  • Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Gene Wiki entry for CXCR6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR6 Gene

Genomics for CXCR6 Gene

Regulatory Elements for CXCR6 Gene

Enhancers for CXCR6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G045983 1.8 FANTOM5 Ensembl ENCODE dbSUPER 32.6 +46.6 46581 6.2 FOXA2 SIN3A ZNF48 YY1 CBX5 FOS NFYC JUNB TBX21 ZNF592 CXCR6 CCRL2 FYCO1 LZTFL1 CCR2 CCR5 CCR1 CCR3
GH03G046088 1.9 FANTOM5 Ensembl ENCODE dbSUPER 27.7 +154.9 154902 13.4 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 BMI1 RAD21 EGR1 ZNF143 FOS CCR1 CCRL2 CXCR6 FYCO1 CCR5 LOC102724297 CCR2 CCR3 CCDC12 LIMD1
GH03G045964 1 ENCODE dbSUPER 31.6 +24.7 24739 1.9 PKNOX1 CEBPG ZBTB40 RELA FOSL1 EED FOS ETV6 IKZF2 CREM CXCR6 LZTFL1 FYCO1
GH03G045991 1.8 FANTOM5 ENCODE dbSUPER 17.4 +53.6 53556 5.3 HDGF PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A YY1 SLC30A9 ZNF766 CXCR6 FYCO1 CCR1 CCDC12 SACM1L CCR5 CCR2
GH03G046106 2 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +171.2 171246 9.6 HDGF PKNOX1 ATF1 FOXA2 WRNIP1 ELK1 ZNF207 FOS DEK JUNB CCR1 CCRL2 CXCR6 FYCO1 CCR2 CCR5 LIMD1 XCR1 CCR3 SACM1L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXCR6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCR6 Gene

Chromosome:
3
Start:
45,940,399 bp from pter
End:
45,948,354 bp from pter
Size:
7,956 bases
Orientation:
Plus strand

Genomic View for CXCR6 Gene

Genes around CXCR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR6 Gene

Proteins for CXCR6 Gene

  • Protein details for CXCR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00574-CXCR6_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 6
    Protein Accession:
    O00574
    Secondary Accessions:
    • O00575
    • Q9HCA5

    Protein attributes for CXCR6 Gene

    Size:
    342 amino acids
    Molecular mass:
    39280 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCR6 Gene

Post-translational modifications for CXCR6 Gene

  • Glycosylation at isoforms=16
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR6 Gene

No data available for DME Specific Peptides for CXCR6 Gene

Domains & Families for CXCR6 Gene

Gene Families for CXCR6 Gene

Suggested Antigen Peptide Sequences for CXCR6 Gene

Graphical View of Domain Structure for InterPro Entry

O00574

UniProtKB/Swiss-Prot:

CXCR6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR6: view

Function for CXCR6 Gene

Molecular function for CXCR6 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Gene Ontology (GO) - Molecular Function for CXCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS 9166430
GO:0004950 chemokine receptor activity IEA --
GO:0015026 coreceptor activity IEA --
GO:0016494 C-X-C chemokine receptor activity IEA --
GO:0019958 C-X-C chemokine binding IEA --
genes like me logo Genes that share ontologies with CXCR6: view
genes like me logo Genes that share phenotypes with CXCR6: view

Animal Models for CXCR6 Gene

MGI Knock Outs for CXCR6:

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCR6

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CXCR6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCR6 Gene

Localization for CXCR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCR6 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for CXCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 9166430
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CXCR6: view

Pathways & Interactions for CXCR6 Gene

genes like me logo Genes that share pathways with CXCR6: view

Gene Ontology (GO) - Biological Process for CXCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0019079 viral genome replication TAS 9230441
genes like me logo Genes that share ontologies with CXCR6: view

No data available for SIGNOR curated interactions for CXCR6 Gene

Drugs & Compounds for CXCR6 Gene

(6) Drugs for CXCR6 Gene - From: ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CXCL16 Pharma Full agonist, Agonist 0
Plerixafor 8HCl (AMD3100 8HCl) Pharma CXCR4 antagonist 0
WZ811 Pharma Competitive CXR4 antagonist,highly potent 0
[<SUP>125</SUP>I]CXCL16 (HUMAN) Pharma 0

(2) Additional Compounds for CXCR6 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CXCL16
Full agonist, Agonist

(2) ApexBio Compounds for CXCR6 Gene

Compound Action Cas Number
Plerixafor 8HCl (AMD3100 8HCl) CXCR4 antagonist 155148-31-5
WZ811 Competitive CXR4 antagonist,highly potent 55778-02-4
genes like me logo Genes that share compounds with CXCR6: view

Drug Products

Transcripts for CXCR6 Gene

Unigene Clusters for CXCR6 Gene

Chemokine (C-X-C motif) receptor 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CXCR6

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR6 Gene

No ASD Table

Relevant External Links for CXCR6 Gene

GeneLoc Exon Structure for
CXCR6
ECgene alternative splicing isoforms for
CXCR6

Expression for CXCR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCR6 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR6 Gene

This gene is overexpressed in Spleen (x8.9), Muscle - Skeletal (x5.6), Whole Blood (x5.3), and Small Intestine - Terminal Ileum (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of CXCR6 Gene:

CXCR6

SOURCE GeneReport for Unigene cluster for CXCR6 Gene:

Hs.34526

mRNA Expression by UniProt/SwissProt for CXCR6 Gene:

O00574-CXCR6_HUMAN
Tissue specificity: Expressed in lymphoid tissues and activated T cells.

Evidence on tissue expression from TISSUES for CXCR6 Gene

  • Blood(4.4)
  • Pancreas(4)
  • Lymph node(2.4)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with CXCR6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCR6 Gene

Orthologs for CXCR6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCR6 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia CXCR6 34 35
  • 84.75 (n)
cow
(Bos Taurus)
Mammalia CXCR6 34 35
  • 82.25 (n)
mouse
(Mus musculus)
Mammalia Cxcr6 34 16 35
  • 79.18 (n)
rat
(Rattus norvegicus)
Mammalia Cxcr6 34
  • 78.04 (n)
oppossum
(Monodelphis domestica)
Mammalia CXCR6 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXCR6 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXCR6 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxcr6 34
  • 55.63 (n)
Species where no ortholog for CXCR6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCR6 Gene

ENSEMBL:
Gene Tree for CXCR6 (if available)
TreeFam:
Gene Tree for CXCR6 (if available)

Paralogs for CXCR6 Gene

genes like me logo Genes that share paralogs with CXCR6: view

Variants for CXCR6 Gene

Sequence variations from dbSNP and Humsavar for CXCR6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000801105 -- 45,943,382(+) TCTGA(G/T)CTGAA intron-variant, upstream-variant-2KB
rs1001167944 -- 45,940,976(+) GCTTA(C/T)AGAAC intron-variant, utr-variant-5-prime
rs1001450996 -- 45,940,582(+) ATAAA(C/G)CCTGG intron-variant, upstream-variant-2KB
rs1001481492 -- 45,940,365(+) TGGGC(A/G)AGTGG intron-variant, upstream-variant-2KB
rs1001494356 -- 45,943,894(+) AAGAC(A/G)GGCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXCR6 Gene

Variant ID Type Subtype PubMed ID
nsv476148 CNV novel sequence insertion 20440878
nsv834678 CNV gain 17160897

Variation tolerance for CXCR6 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCR6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR6 Gene

Disorders for CXCR6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXCR6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
xanthogranulomatous cholecystitis
  • cx
- elite association - COSMIC cancer census association via MalaCards
Search CXCR6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCR6

Genetic Association Database (GAD)
CXCR6
Human Genome Epidemiology (HuGE) Navigator
CXCR6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCR6
genes like me logo Genes that share disorders with CXCR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR6 Gene

Publications for CXCR6 Gene

  1. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV- 1. (PMID: 9166430) Liao F. … Farber J.M. (J. Exp. Med. 1997) 2 3 4 22 64
  2. Expression cloning of new receptors used by simian and human immunodeficiency viruses. (PMID: 9230441) Deng H.K. … Littman D.R. (Nature 1997) 2 3 4 64
  3. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. (PMID: 9285716) Loetscher M. … Moser B. (Curr. Biol. 1997) 3 4 22 64
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 46 64
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &amp;quot;hot-spot&amp;quot;. (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64

Products for CXCR6 Gene

  • Addgene plasmids for CXCR6

Sources for CXCR6 Gene

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