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CXCR5 Gene

protein-coding   GIFtS: 62
GCID: GC11P118754

Chemokine (C-X-C Motif) Receptor 5

(Previous names: Burkitt lymphoma receptor 1, GTP-binding protein, Burkitt...)
(Previous symbol: BLR1)
  See CXCR5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Receptor 51 2     MDR-152 3
BLR11 2 3 5     MDR152 3
Burkitt Lymphoma Receptor 1, GTP Binding Protein (Chemokine (C-X-C Motif)
Receptor 5)1 2
     CD1852
Burkitt Lymphoma Receptor 1, GTP-Binding Protein1 2     C-X-C Chemokine Receptor Type 52
Monocyte-Derived Receptor 152 3     Burkitt Lymphoma Receptor 13
CXC-R52 3     CD185 Antigen3
CXCR-52 3     

External Ids:    HGNC: 10601   Entrez Gene: 6432   Ensembl: ENSG000001606837   OMIM: 6016135   UniProtKB: P323023   

Export aliases for CXCR5 gene to outside databases

Previous GC identifers: GC11P118260 GC11P114694


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCR5 Gene:
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed
in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and
is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced
transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for CXCR5 Gene:
CXCR5 (chemokine (C-X-C motif) receptor 5) is a protein-coding gene. Diseases associated with CXCR5 include burkitt's lymphoma, and intraocular lymphoma. GO annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CXCR5_HUMAN, P32302
Function: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into
B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have
a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation

Gene Wiki entry for CXCR5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCR5 gene promoter:
         E2F-4   E2F-3a   E2F-5   STAT1   E2F-1   E2F   E2F-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCR5 promoter sequence
   Search Chromatin IP Primers for CXCR5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

CXCR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCR5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118754:  view genomic region     (about GC identifiers)

Start:
118,754,475 bp from pter      End:
118,768,508 bp from pter
Size:
14,034 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CXCR5_HUMAN, P32302 (See protein sequence)
Recommended Name: C-X-C chemokine receptor type 5  
Size: 372 amino acids; 41955 Da
Secondary accessions: Q14811
Alternative splicing: 2 isoforms:  P32302-1   P32302-2   

Explore the universe of human proteins at neXtProt for CXCR5: NX_P32302

Explore proteomics data for CXCR5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn28, Asn196
  • Modification sites at PhosphoSitePlus

  • See CXCR5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001707.1  NP_116743.1  

    ENSEMBL proteins: 
     ENSP00000292174  
    Reactome Protein details: P32302

    CXCR5 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CXCR5
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    Novus Biologicals CXCR5 Proteins
    Novus Biologicals CXCR5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CXCR5

     
    Search eBioscience for Proteins for CXCR5 

    CXCR5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CXCR5
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    CXCR5 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CXCR5
    Cloud-Clone Corp. CLIAs for CXCR5
    Search eBioscience for ELISAs for CXCR5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CXCR: GPCR / Class A : Chemokine receptors : C-X-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CXCR5
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001053 Chemokine_CXCR5
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32302

    ProtoNet protein and cluster: P32302

    1 Blocks protein domain: IPB001053 Burkitt's lymphoma receptor signature

    UniProtKB/Swiss-Prot: CXCR5_HUMAN, P32302
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CXCR5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCR5_HUMAN, P32302
    Function: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into
    B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have
    a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS1425907
    GO:0005515protein binding IPI--
    GO:0016494C-X-C chemokine receptor activity IEA--
         
    Find genes that share ontologies with CXCR5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CXCR5:
     Abundance of large cells with   Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cxcr5):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with CXCR5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cxcr5tm1Lipp for CXCR5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCR5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCR5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCR5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCR5

    miRNA
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    Block miRNA regulation of human, mouse, rat CXCR5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CXCR5 (see all 22):
    hsa-miR-3200-5p hsa-miR-631 hsa-miR-192 hsa-miR-3661 hsa-miR-486-5p hsa-miR-4314 hsa-miR-214* hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidCXCR5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CXCR5
    Predesigned siRNA for gene silencing in human, mouse, rat CXCR5

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CXCR5 (NM_032966)
    Sino Biological Human cDNA Clone for CXCR5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR5

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXCR5_HUMAN, P32302: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1425907
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with CXCR5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXCR5 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47


    Find genes that share SuperPaths with CXCR5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CXCR5
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCR5 (see all 7)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling

    2 BioSystems Pathways for CXCR5
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    2 Reactome Pathways for CXCR5
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    2 Kegg Pathways  (Kegg details for CXCR5):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCR5 (see all 6): 
              G Protein Coupled Receptors 384HT in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CXCR5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CXCR5 (P323022, 3 ENSP000002921744) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAO1P094712, 3, ENSP000002624934MINT-50706 I2D: score=1 STRING: ENSP00000262493
    GNAQP501482, 3, ENSP000002865484MINT-50705 I2D: score=1 STRING: ENSP00000286548
    GNAI2P048992, 3, ENSP000003129994MINT-50704 MINT-50707 I2D: score=1 STRING: ENSP00000312999
    CXCL13O439273, ENSP000002867584I2D: score=2 STRING: ENSP00000286758
    CTR9Q6PD623I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS1425907
    GO:0006935chemotaxis IEA--
    GO:0006955immune response IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS1425907
    GO:0032467positive regulation of cytokinesis IMP--

    Find genes that share ontologies with CXCR5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXCR5

    1 IUPHAR Ligand for CXCR5 (CXCR5)    About this table
    LigandTypeActionAffinityPubmed IDs
    CXCL13
    AgonistFull agonist--

    6 Novoseek inferred chemical compound relationships for CXCR5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peg-10 68 3 16225771 (2), 17082584 (1)
    rantes 44.6 4 19127964 (1), 7639692 (1), 11994442 (1)
    retinoic acid 17.9 45 18006504 (6), 10640427 (4), 12324654 (4), 14993281 (2) (see all 5)
    calcitriol 7.19 2 10640427 (1), 12324654 (1)
    calcium 0 4 9463416 (1), 9486651 (1), 11554781 (1), 14600836 (1)
    dmso 0 1 10640427 (1)



    Find genes that share compounds with CXCR5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CXCR5 gene (2 alternative transcripts): 
    NM_001716.4  NM_032966.2  

    Unigene Cluster for CXCR5:

    Chemokine (C-X-C motif) receptor 5
    Hs.113916  [show with all ESTs]
    Unigene Representative Sequence: NM_001716
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000292174(uc001pue.4)
    miRNA
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    hsa-miR-3200-5p hsa-miR-631 hsa-miR-192 hsa-miR-3661 hsa-miR-486-5p hsa-miR-4314 hsa-miR-214* hsa-miR-641
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      QuantiFast Probe-based Assays in human, mouse, rat CXCR5

    Additional mRNA sequence: 

    AK291512.1 BC110352.1 X68149.1 X68829.1 

    3 DOTS entries:

    DT.40250888  DT.212254  DT.120727407 

    Selected AceView cDNA sequences (see all 46):

    AA805708 CD366579 AA904965 AA769322 BE465642 AW575330 NM_032966 AA828508 
    AA828522 AI432818 CF147771 NM_001716 AI248627 AW575592 BQ057309 BQ056144 
    AW408741 BM922349 BQ055067 BF794688 AW575590 X68149 X68829 AA862756 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXCR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTACACTT
    CXCR5 Expression
    About this image


    CXCR5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Immature B-Cells Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Tonsil (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    CXCR5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXCR5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.113916

    UniProtKB/Swiss-Prot: CXCR5_HUMAN, P32302
    Tissue specificity: Expression in mature B-cells and Burkitt lymphoma cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCR5 (see all 6): 
              G Protein Coupled Receptors 384HT in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXCR5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcr51 , 5 chemokine (C-X-C motif) receptor 51, 5 81.45(n)1
    83.6(a)1
      9 (24.84 cM)5
    121451  NM_007551.21  NP_031577.21 
     445117875 
    chicken
    (Gallus gallus)
    Aves CXCR51 chemokine (C-X-C motif) receptor 5 58.87(n)
    48.54(a)
      419784  NM_001030912.1  NP_001026083.1 
    lizard
    (Anolis carolinensis)
    Reptilia CXCR56
    chemokine (C-X-C motif) receptor 5
    44(a)
    1 ↔ 1
    GL344088.1(19679-20785)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cxcr51 chemokine (C-X-C motif) receptor 5 53.63(n)
    48.58(a)
      100495113  XM_002932923.2  XP_002932969.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005374211 c-X-C chemokine receptor type 5-like 52.93(n)
    41.21(a)
      100537421  XM_003200482.2  XP_003200530.2 


    ENSEMBL Gene Tree for CXCR5 (if available)
    TreeFam Gene Tree for CXCR5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CXCR5 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    CCR72  ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  
    CCR22  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CXCR5 using alignment to 2 protein entries:     CXCR5_HUMAN (see all proteins) (see all similar genes):
    BLR1    CCR7    CXCR4    CCR8    CCR9    CCR2
    CXCR2    IL8RB    CCR1    CXCR1    CXCR3    CCR5
    CX3CR1    CCR6    SSTR1    CXCR6    CCR4    SSTR4

    Find genes that share paralogs with CXCR5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXCR5 (see all 324)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357574
    A breast cancer sample4--see VAR_0357572 E K mis40--------
    rs735588621,2
    C,F--118752542(+) AAGCCG/ATCTTC 1 -- us2k13Minor allele frequency- A:0.03WA 122
    rs1906191991,2
    --118752595(+) GAAACA/GACCCC 1 -- us2k10--------
    rs1131929991,2
    C,F--118752615(+) AACAGT/AGGCTG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1508104071,2
    --118752667(+) TTGGCC/TGGGCA 1 -- us2k10--------
    rs571580151,2
    C--118752734(+) TTAGGT/ACAGGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1864585711,2
    --118752804(+) GCCGGA/GCGTGG 1 -- us2k10--------
    rs1396812341,2
    C--118752966(+) AAATAC/GAAAAT 1 -- us2k10--------
    rs1897043431,2
    --118753010(+) AGATGC/TTCGGG 1 -- us2k10--------
    rs1809388511,2
    --118753012(+) ATGCTC/TGGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CXCR5 (118754475 - 118768508 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CXCR5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCR5
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCR5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601613    OMIM disorders: --

    4 diseases for CXCR5:    
    About MalaCards
    burkitt's lymphoma    intraocular lymphoma    malt lymphoma    b-cell chronic lymphocytic leukemia

    1 disease from the University of Copenhagen DISEASES database for CXCR5:
    Lymphoma

    Find genes that share disorders with CXCR5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CXCR5 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    burkitt lymphoma 65.5 25 9486651 (2), 8405054 (1), 7920182 (1), 7639692 (1) (see all 11)
    b-all 59.8 6 16225771 (2), 17082584 (2), 16118018 (1), 11368435 (1)
    intraocular lymphoma 54.6 1 12578791 (1)
    lymphoma b-cell 51.8 1 12855271 (1)
    leukemia lymphocytic chronic 49.2 4 15580304 (1), 16225771 (1), 17652619 (1), 15155773 (1)
    primary central nervous system lymphoma 44.4 1 15967804 (1)
    malt lymphoma 38.7 2 10562310 (2)
    lymphoma 30.2 9 12578791 (2), 8405054 (1), 7920182 (1), 19536742 (1) (see all 7)
    lymphoproliferative disorders 26 4 12855271 (1), 12614207 (1), 15621766 (1), 11368435 (1)
    rheumatoid arthritis 23.2 1 16207316 (1)

    Genetic Association Database (GAD): CXCR5
    Human Genome Epidemiology (HuGE) Navigator: CXCR5 (7 documents)

    Export disorders for CXCR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXCR5 gene, integrated from 10 sources (see all 178):
    (articles sorted by number of sources associating them with CXCR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma. (PubMed id 1425907)1, 2, 3, 9 Dobner T.... Lipp M. (Eur. J. Immunol. 1992)
    2. Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation. (PubMed id 7639692)1, 2, 9 Barella L.... Moser B. (Biochem. J. 1995)
    3. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. (PubMed id 9463416)1, 2, 9 Legler D.F.... Moser B. (J. Exp. Med. 1998)
    4. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    7. Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines. (PubMed id 19610059)1, 9 Singh S....Lillard J.W. (Int. J. Cancer 2009)
    8. The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases. (PubMed id 14763921)1, 9 Aust G....SchmA1cking E. (Eur. J. Endocrinol. 2004)
    9. Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells. (PubMed id 12324654)1, 9 Battle T.E. and Yen A. (Exp. Biol. Med. (Maywood) 2002)
    10. The CXCR5 chemokine receptor is expressed by carcinoma cells and promotes growth of colon carcinoma in the liver. (PubMed id 17018614)1, 9 Meijer J....Roos E. (Cancer Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 643 HGNC: 1060 AceView: BLR1 Ensembl:ENSG00000160683 euGenes: HUgn643
    ECgene: CXCR5 Kegg: 643 H-InvDB: CXCR5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXCR5 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXCR5 gene:
    Search GeneIP for patents involving CXCR5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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