Aliases for CXCR4 Gene
- C-X-C Motif Chemokine Receptor 4 2 3 5
- Leukocyte-Derived Seven Transmembrane Domain Receptor 3 4
- Lipopolysaccharide-Associated Protein 3 3 4
- Stromal Cell-Derived Factor 1 Receptor 3 4
- Chemokine (C-X-C Motif) Receptor 4 2 3
- LPS-Associated Protein 3 3 4
- SDF-1 Receptor 3 4
- CD184 Antigen 3 4
- Fusin 3 4
- LAP-3 3 4
- LESTR 3 4
- NPYRL 3 4
- FB22 3 4
- HM89 3 4
- LCR1 3 4
- Seven-Transmembrane-Segment Receptor, Spleen 3
- Chemokine (C-X-C Motif), Receptor 4 (Fusin) 2
External Ids for CXCR4 Gene
Previous GeneCards Identifiers for CXCR4 Gene
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for CXCR4 Gene
CXCR4 (C-X-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include Whim Syndrome and Human Immunodeficiency Virus Infectious Disease. Among its related pathways are Peptide ligand-binding receptors and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. GO annotations related to this gene include G-protein coupled receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is CXCR2.
UniProtKB/Swiss-Prot for CXCR4 Gene
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:9427609, PubMed:10074122, PubMed:10756055). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
Chemokine receptors are 7-transmembrane G protein-coupled receptors that are activated by the binding of one or more chemokines. Chemokines are a family of chemoattractant molecules with more than 50 having been identified to date. They are categorized according to the number and spacing of conserved cysteines into four main groups: CXC, CC, CX3C and C.