V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CXCR4 Gene

protein-coding GIFtS: 74

GC02M136588

chemokine (C-X-C motif) receptor 4
(Previous names: chemokine (C-X-C motif), receptor 4 (fusin) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD184 ^¹, ²
CXC-R4 ^³
CXCR-4 ^³
D2S201E ^¹, ², ⁵
FB22 ^², ³
Fusin ^³
HM89 ^¹, ², ³
HSY3RR ^¹, ²
LAP3 ^²
LCR1 ^², ³
LESTR ^¹, ², ³
NPY3R ^¹, ², ⁵
NPYR ^¹, ²
NPYRL ^², ³
NPYY3R ^¹, ²
WHIM ^², ⁵
fusin ^¹, ²

Descriptions
C-X-C chemokine receptor type 4 ^²
CD184 antigen ^², ³
Leukocyte-derived seven transmembrane domain receptor ^³
SDF-1 receptor ^³
Stromal cell-derived factor 1 receptor ^², ³
chemokine (C-X-C motif) receptor 4 ^²
chemokine (C-X-C motif), receptor 4 (fusin) ^¹
leukocyte-derived seven-transmembrane-domain receptor ^²
lipopolysaccharide-associated protein 3 ^²
neuropeptide Y receptor Y3 ^²
seven transmembrane helix receptor ^²
seven-transmembrane-segment receptor, spleen ^²

External Ids
HGNC: 2561¹
Entrez Gene: 7852²
UniProtKB: P61073³
Ensembl: ENSG00000121966⁷

Search outside databases for aliases for CXCR4 gene

Previous GC identifers: GC02M134526 GC02M135169 GC02M136894 GC02M137082 GC02M136705

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CXCR4:

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein

has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to

support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in

this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and

myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms,

have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: CXCR4_HUMAN, P61073

Function: Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the

intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum

formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably

by regulating vascular branching and/or remodeling processes in endothelial cells. Could be

involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as

a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for

some HIV-2 isolates. Promotes Env-mediated fusion of the virus

Gene Wiki entry for CXCR4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CXCR4 gene

Entrez Gene cytogenetic band: 2q21 Ensembl cytogenetic band: 2q21.3 HGNC cytogenetic band: 2q21

CXCR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M136588: (about GC identifiers)

Start:	136,588,389 bp from pter
End:	136,592,205 bp from pter
Size:	3,817 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022135.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CXCR4_HUMAN, P61073 (See protein sequence)

Recommended Name: C-X-C chemokine receptor type 4

Size: 352 amino acids; 39746 Da

Subunit: Monomer. Can form dimers. Interacts with HIV-1 surface protein gp120 and Tat

Subcellular location: Cell membrane; Multi-pass membrane protein

Caution: Was originally (PubMed:8329116 and PubMed:8234909) thought to be a receptor for

neuropeptide Y type 3 (NPY3R) (NPY3-R)

PDB structures from and Proteopedia :

2K03 (3D)

2K04 (3D)

2K05 (3D)

Secondary accessions: O60835 P30991 P56438 Q9UKN2

Alternative splicing: 2 isoforms: P61073-1, P30991-1 P61073-2, P30991-2 (Additional isoforms seem to exist)

Post-translational modifications:

Sulfation on Tyr-21 is required for efficient binding of CXCL12/SDF-1alpha and promotes its

dimerization¹

O- and N-glycosylated. Asn-11 is the principal site of N-glycosylation. There appears to be very

little or no glycosylation on Asn-176. N-glycosylation masks coreceptor function in both X4 and R5

laboratory-adapted and primary HIV-1 strains through inhibiting interaction with their Env

glycoproteins. The O-glycosylation chondroitin sulfate attachment does not affect interaction with

CXCL12/SDF-1alpha nor its coreceptor activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001008540.1 NP_003458.1

ENSEMBL proteins:

ENSP00000241393 ENSP00000386884

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CXCR4 Protein
	Sigma-Aldrich CompoZr ZFN for CXCR4
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CXCR4)
	Human Recombinant Proteins from Abnova (CXCR4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	10415069
GO:0005886	plasma membrane	TAS	10393923 10644702
GO:0005887	integral to plasma membrane	TAS	10644702
GO:0031252	cell leading edge	IDA	12421915

About this table

Antibodies for CXCR4:

	Invitrogen Antibodies for CXCR4
	Millipore Mono- and Polyclonal Antibodies for the study of CXCR4
	Sigma-Aldrich Antibodies for CXCR4
	R&D Systems Antibodies for CXCR4
	Antibodies from Abcam (CXCR4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CXCR4)
	Novus Biologicals Antibodies for CXCR4

Assays for CXCR4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P61073

ProtoNet protein and cluster: P61073

2 Blocks protein families:

IPB000355 Chemokine receptor signature

IPB001277 LCR1 orphan receptor signature

UniProtKB/Swiss-Prot: CXCR4_HUMAN, P61073

Domain: The amino-terminus is critical for ligand binding. Residues in all four extracellular

regions contribute to HIV-1 coreceptor activity

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCR4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CXCR4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003467

Applied Biosystems Silencer® siRNAs for CXCR4

Sigma-Aldrich siRNA and siRNA Panels for CXCR4

Sigma-Aldrich shRNA Panels and shRNA for CXCR4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CXCR4
		Millipore Clones for the Expression of CXCR4

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001008540
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001008540
untagged cDNA clones in CMV expression vector (see all 2): NM_001008540

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001008540

UniProtKB/Swiss-Prot: CXCR4_HUMAN, P61073

Function: Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the

intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum

formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably

by regulating vascular branching and/or remodeling processes in endothelial cells. Could be

involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as

a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for

some HIV-2 isolates. Promotes Env-mediated fusion of the virus

Genatlas biochemistry entry for CXCR4:

fusin,chemokine (CXC) motif,receptor 4,preferentially expressed on the more immature CD34+

hematopoietic stem cells,G protein coupled receptor superfamily,required for entry of T cell

line-tropic strains HIV-1 into CD4 cells,bovine locus coeruleus homolog

13 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cxcr4):

	digestive/alimentary	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	muscle	nervous system
renal/urinary system	reproductive system	respiratory system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IDA	12421915
GO:0004930	G-protein coupled receptor activity	TAS	8276799
GO:0005515	protein binding	IPI	12421915
GO:0015026	coreceptor activity	TAS	10754293
GO:0016493	C-C chemokine receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for CXCR4 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Ephrin Receptor Signaling
Chemokine Signaling
Leukocyte Extravasation Signaling
Axonal Guidance Signaling
Induction of Apoptosis by HIV1

GeneDecks CXCR4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CXCR4

5/154 Interacting proteins for CXCR4 (ENSP00000241393³ P61073¹) via UniProtKB, MINT, and/or STRING (see all 154 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYH9	P35579¹	EBI-489411, EBI-350338
CD4	ENSP00000011653³	STRING (score=.999)
CXCL12	ENSP00000363548³	STRING (score=.999)
CCL5	ENSP00000293272³	STRING (score=.993)
SDC4	ENSP00000361818³	STRING (score=.983)

About this table

5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	TAS	10570282
GO:0001666	response to hypoxia	IEP	15174142
GO:0006915	apoptosis	TAS	10942389
GO:0006935	chemotaxis	TAS	10802710
GO:0006954	inflammatory response	TAS	8276799

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for CXCR4 available from Tocris Bioscience

Compound	Action	CAS number
AMD 3100 octahydrochloride	Highly selective CXCR4 antagonist	[155148-31-5]

About this table

10/35 Novoseek chemical compound relationships for CXCR4 gene (see all 35 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	83.60	66	14717979 (2), 19127964 (2), 11064099 (2), 10679062 (2) (see all 52)
sdf 1	81.99	69	18698020 (8), 10656438 (6), 17108064 (6), 15781337 (3) (see all 21)
c-d4i	69.23	1	12208966 (1)
cgp64222	63.76	1	10617686 (1)
jm2763	62.28	1	10400726 (1)
mdms	56.39	5	11049991 (2), 15804293 (2), 12699419 (1)
ccl3	54.12	8	15818740 (1), 19001077 (1), 15542651 (1), 11145678 (1) (see all 7)
cyclam	52.81	2	18671217 (1), 9882699 (1)
matrigel	50.61	10	17521613 (2), 12791666 (1), 15059909 (1), 15705897 (1) (see all 8)
tyrosine sulfate	49.83	2	12034737 (1), 18799424 (1)

About this table

1 PharmGKB drug compound relationship for CXCR4 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
IL-2	PD	10203379

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCR4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CXCR4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003467

Sigma-Aldrich siRNA and siRNA Panels for CXCR4

Sigma-Aldrich shRNA Panels and shRNA for CXCR4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001008540 NM_003467

REFSEQ mRNAs for CXCR4 gene (2 alternative transcripts):

NM_001008540.1 NM_003467.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001008540 NM_003467

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001008540
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001008540
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001008540

Additional cDNA sequence:

AF025375.1 AF147204.1 AF348491.1 AK129916.1 AK296674.1 AK309641.1 AK309885.1 AK312244.1

AY242129.1 AY826773.1 BC020968.2 BT006660.1 CR594428.1 CR594588.1 CR596547.1 CR598681.1

CR598713.1 CR601301.1 CR604071.1 CR605131.1 CR610268.1 CR614199.1 CR614594.1 CR614663.1

CR619476.1 CR623838.1 D10924.1 L01639.1 L06797.1 M99293.1 X71635.1

10 DOTS entries:

DT.99966073 DT.317915 DT.100879775 DT.95300550 DT.100758882 DT.121009420 DT.91841237 DT.92435681

DT.100804810 DT.86667426

24/263 AceView cDNA sequences (see all 263 ):

CR596547 BQ718617 CR614663 CR614594 CR598681 BI754094 BI916212 CD251331

BX439223 BP366593 BP338386 BM920800 AA426566 AA386000 BP367699 CR623838

CR594588 BX397685 CR614199 AA299445 AF025375 BX089192 X71635 AY242129

highest scoring ESTs for CXCR4:

L06797 AA091989 AA148292 AA225739 AA248174 AA299445 AA339027 AA353051 AA353948 AA354040

Unigene Cluster for CXCR4:

Chemokine (C-X-C motif) receptor 4

Hs.593413 [show with all ESTs]

Unigene Representative Sequence: AF147204

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000241393 ENST00000409817

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CXCR4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CXCR4

¹ / ² / ³

7 probe-sets matching CXCR4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
649_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L06797	1.00	1.00	1.00	1
211919_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF348491	0.80	1.00	0.91	1
217028_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
209201_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L01639	0.80	1.00	0.91	1
211919_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217028_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209201_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CXCR4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAAACTTAA

SOURCE GeneReport for Unigene cluster: Hs.593413
Expression variation in blood from EXPOLDB for CXCR4
UniProtKB/Swiss-Prot: CXCR4_HUMAN, P61073
Tissue specificity: Expressed in numerous tissues, such as peripheral blood leukocytes, spleen,
thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum,
cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary
artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CXCR4 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CXCR4¹	--	chemokine (C-X-C motif) receptor 4	91.31(n) 95.99(a)	483900 XM_541020.2 XP_541020.2
chimpanzee (Pan troglodytes)	CXCR4¹	--	chemokine (C-X-C motif) receptor 4	99.81(n) 100(a)	450130 NM_001009047.1 NP_001009047.1
cow (Bos taurus)	CXCR4¹	--	chemokine (C-X-C motif) receptor 4	90.25(n) 92.61(a)	281736 NM_174301.3 NP_776726.1
rat (Rattus norvegicus)	Cxcr4¹	--	chemokine (C-X-C motif) receptor 4	85.48(n) 91.4(a)	60628 NM_022205.3 NP_071541.2
mouse (Mus musculus)	Cxcr4^{1, 5}	1 (67.40 cM)⁵	chemokine (C-X-C motif) receptor 4^{1, 5}	86.63(n)¹ 91.12(a)¹	12767¹ NM_009911.3¹ NP_034041.2¹ AB000803⁵ AK088663⁵ (see all 17)

About this table Species with no ortholog for CXCR4

ENSEMBL Gene Tree for CXCR4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CXCR4 gene

CXCR5² IL8RA² IL8RB² CXCR3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/40 NCBI SNPs in CXCR4 are shown (see all 40 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 38)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3806501^1,2	C,F,H	136593539(-)	`GCAGTC/ATGGGC`	1	--	ng3¹		5	EA EU WA	1916
--	rs17848047^1,2	C,F	136593642(-)	`TGCTCT/CGTAGA`	1	--	ng3¹		8	NS	758
	rs11682928^1,2	C,F	136591376(+)	`GAGGCG/ACGCTT`	2	--	ng3¹ int¹		2	NS	92
--	rs17848056^1,2	C,F	136590588(-)	`ATACCC/TCAAGC`	2	--	ng3¹ int¹		8	NS	722
	rs2471859^1,2	C,F	136590474(-)	`TGCGCT/CTTAGG`	2	--	ng3¹ int¹		8	NS	744
	rs2680880^1,2	C,F	136590019(+)	`AAAAAA/TTTTTT`	2	--	ut5¹ int¹		8	NS	744
--	rs17848059^1,2	F	136588880(-)	`TATACG/AATAAA`	2	--	ut3¹		2	NS	90
--	rs17848052^1,2	F	136592268(-)	`CGCCTT/CCTCCC`	2	--	ng3¹ trp³		2	NS	92
--	rs17848385^1,2	F	136591162(-)	`GGTGCA/CAGTGG`	2	--	int¹ ng3¹		2	NS	90
	rs1112156^1,2	C	136593184(-)	`GGGGAC/ACGAAG`	1	--	ng3¹		3	MN NS	276

About this table

HapMap Linkage Disequilibrium images for CXCR4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 162643

UniProtKB/Swiss-Prot: CXCR4_HUMAN, P61073

Defects in CXCR4 are a cause of WHIM syndrome [MIM:193670]; also called warts,

hypogammaglobulinemia, infections, and myelokathexis. WHIM syndrome is an immunodeficiency disease

characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV)

infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals

contain abundant mature myeloid cells, a condition termed myelokathexis

10/93 Novoseek disease relationships for CXCR4 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
whim syndrome	88.04	26	15026312 (2), 15781337 (2), 16154852 (2), 16899028 (2) (see all 15)
immunodeficiency	84.61	347	9343175 (3), 10074102 (3), 9108384 (2), 9160656 (2) (see all 99)
hiv infections	69.89	74	9108384 (2), 14741421 (2), 10779364 (2), 10823791 (2) (see all 57)
metastasis	67.61	419	16230077 (6), 12499276 (6), 15240098 (6), 17355795 (6) (see all 99)
aids dementia complex	57.32	3	11115360 (1), 9327737 (1), 11218674 (1)
hypogammaglobulinemia	57.01	5	15026312 (1), 18436740 (1), 15604887 (1)
aids	56.57	68	16138573 (5), 10499817 (2), 11305873 (2), 17199940 (2) (see all 48)
tumors	50.06	439	16269611 (6), 18593989 (6), 18701133 (5), 15472715 (5) (see all 99)
virus infection	48.62	39	8709256 (1), 11287575 (1), 11448156 (1), 15306840 (1) (see all 34)
cancer	47.83	196	18987663 (4), 16357147 (4), 16823836 (4), 16675573 (3) (see all 99)

About this table

1 PharmGKB disease relationship for CXCR4 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
HIV	PD	10203379

About this table

Human Gene Mutation Database: CXCR4
Genetic Association Database: CXCR4
Human Genome Epidemiology Navigator: CXCR4 (46 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1616 PubMed articles for CXCR4 gene (see all 1616 ):

Genomic organization and promoter characterization of human CXCR4 gene. (PubMed id 9599023)^{1, 2, 3, 4} Caruz A.... Arenzana-Seisdedos F. (1998)
Identification of CXCR4 domains that support coreceptor and chemokine receptor functions. (PubMed id 10074122)^{1, 3, 4} Doranz B.J.... Doms R.W. (1999)
Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry. (PubMed id 9379028)^{1, 2, 3} Moriuchi M....Fauci A.S. (1997)
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. (PubMed id 8752280)^{1, 3, 4} Bleul C.C.... Springer T.A. (1996)
Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population. (PubMed id 16284526)^{1, 3, 6} Petersen D.C....Hayes V.M. (2005)
Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. (PubMed id 9468539)^{1, 3, 4} Wegner S.A....Michael N.L. (1998)
Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PubMed id 7505609)^{1, 3, 4} Nomura H.... Matsushima K. (1993)
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. (PubMed id 12692554)^{1, 3, 4} Hernandez P.A.... Diaz G.A. (2003)
The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry. (PubMed id 12034737)^{1, 3, 4} Farzan M....Choe H. (2002)
Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3'A, CCR2-641, and CCR5-delta32) in global populations. (PubMed id 11175286)^{1, 3, 6} Su B....Jin L. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7852	HGNC: 2561	AceView: CXCR4	Ensembl:ENSG00000121966	euGenes: HUgn7852
ECgene: CXCR4	H-InvDB: CXCR4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CXCR4	Genetics and Cytogenetics in Oncology and Haematology
CXCR4base	http://bioinf.uta.fi/CXCR4base/
Wikipedia	http://en.wikipedia.org/wiki/CXC_chemokine_receptors
Wikipedia	http://en.wikipedia.org/wiki/CXCR4
SeattleSNPs	http://pga.gs.washington.edu/data/cxcr4/

Licensable Technologies for CXCR4
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for CXCR4 gene:

	Weizmann Institute:	Enrichment of Repopulating Stem Cells For Clinical Protocols
	Salk Institute:	Alpha-Complementation Viral Fusion Assay

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CXCR4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CXCR4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CXCR4		Antibodies for CXCR4
	Explore super-pooled esiRNAs		Proteins for CXCR4
	Lentivirus-delivered shRNAs for CXCR4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CXCR4)
	Antibodies (CXCR4)
	Chimera RNAi (CXCR4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CXCR4)
	Antibodies (CXCR4)

Search OriGene for CXCR4

Tocris compounds for CXCR4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CXCR4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CXCR4 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CXCR4 Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for CXCR4

Summaries
for CXCR4

Genomic Location
for CXCR4

Proteins
for CXCR4

Protein Domains/
Families
for CXCR4

Gene Function
for CXCR4

Pathways & Interactions
for CXCR4

Drugs & Compounds
for CXCR4

Transcripts
for CXCR4

Expression
for CXCR4

Orthologs
for CXCR4

Paralogs
for CXCR4

SNPs/Variants
for CXCR4

Disorders & Mutations
for CXCR4

Medical News
for CXCR4

Publications
for CXCR4

Search for CXCR4

Genome Databases showing CXCR4

Other Databases showing CXCR4

Specialized Databases showing CXCR4

Licensable Technologies
for CXCR4

Services
for CXCR4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CXCR4 (Gene Symbol)
CD184
CXC-R4
CXCR-4
D2S201E
FB22
Fusin
HM89
HSY3RR
LAP3
LCR1
LESTR
NPY3R
NPYR
NPYRL
NPYY3R
WHIM
fusin
C-X-C chemokine receptor type 4
CD184 antigen
Leukocyte-derived seven transmembrane domain receptor
SDF-1 receptor
Stromal cell-derived factor 1 receptor
chemokine (C-X-C motif) receptor 4
chemokine (C-X-C motif), receptor 4 (fusin)
leukocyte-derived seven-transmembrane-domain receptor
lipopolysaccharide-associated protein 3
neuropeptide Y receptor Y3
seven transmembrane helix receptor
seven-transmembrane-segment receptor, spleen

CXCR4 Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor CXCR4

Summariesfor CXCR4

Genomic Locationfor CXCR4

Proteinsfor CXCR4

Protein Domains/Familiesfor CXCR4

Gene Functionfor CXCR4

Pathways & Interactionsfor CXCR4

Drugs & Compoundsfor CXCR4

Transcriptsfor CXCR4

Expression for CXCR4

Orthologsfor CXCR4

Paralogsfor CXCR4

SNPs/Variantsfor CXCR4

Disorders & Mutationsfor CXCR4

Medical Newsfor CXCR4

Publicationsfor CXCR4

Search for CXCR4

Genome Databases showing CXCR4

Other Databases showing CXCR4

Specialized Databases showing CXCR4

Licensable Technologiesfor CXCR4

Servicesfor CXCR4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CXCR4

Summaries
for CXCR4

Genomic Location
for CXCR4

Proteins
for CXCR4

Protein Domains/
Families
for CXCR4

Gene Function
for CXCR4

Pathways & Interactions
for CXCR4

Drugs & Compounds
for CXCR4

Transcripts
for CXCR4

Expression
for CXCR4

Orthologs
for CXCR4

Paralogs
for CXCR4

SNPs/Variants
for CXCR4

Disorders & Mutations
for CXCR4

Medical News
for CXCR4

Publications
for CXCR4

Licensable Technologies
for CXCR4

Services
for CXCR4