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Aliases for CXCR3 Gene

Aliases for CXCR3 Gene

  • Chemokine (C-X-C Motif) Receptor 3 2 3
  • G Protein-Coupled Receptor 9 2 3 4
  • GPR9 3 4 6
  • Interferon-Inducible Protein 10 Receptor 3 4
  • IP-10 Receptor 3 4
  • CKR-L2 3 4
  • CXC-R3 3 4
  • CXCR-3 3 4
  • CD182 3 6
  • C-X-C Chemokine Receptor Type 3 3
  • Chemokine (C-X-C) Receptor 3 3
  • IP10 Receptor 3
  • CD183 Antigen 4
  • Mig Receptor 3
  • CMKAR3 3
  • IP10-R 3
  • CD183 3
  • Mig-R 3
  • MigR 3

External Ids for CXCR3 Gene

Previous HGNC Symbols for CXCR3 Gene

  • GPR9

Previous GeneCards Identifiers for CXCR3 Gene

  • GC0XM067009
  • GC0XM068313
  • GC0XM069068
  • GC0XM069702
  • GC0XM070618
  • GC0XM070752
  • GC0XM064650
  • GC0XM070835

Summaries for CXCR3 Gene

Entrez Gene Summary for CXCR3 Gene

  • This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

GeneCards Summary for CXCR3 Gene

CXCR3 (Chemokine (C-X-C Motif) Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include lichen planus and intermediate uveitis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include chemokine receptor activity and chemokine binding. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CXCR3 Gene

  • Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.

  • Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.

  • Isoform 3: Mediates the activity of CXCL11

Gene Wiki entry for CXCR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR3 Gene

Genomics for CXCR3 Gene

Regulatory Elements for CXCR3 Gene

Genomic Location for CXCR3 Gene

Start:
71,615,916 bp from pter
End:
71,618,517 bp from pter
Size:
2,602 bases
Orientation:
Minus strand

Genomic View for CXCR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR3 Gene

Proteins for CXCR3 Gene

  • Protein details for CXCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49682-CXCR3_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 3
    Protein Accession:
    P49682
    Secondary Accessions:
    • B2R982
    • O15185
    • Q7Z710
    • Q9P2T4
    • Q9P2T5

    Protein attributes for CXCR3 Gene

    Size:
    368 amino acids
    Molecular mass:
    40660 Da
    Quaternary structure:
    • Homomer. Forms heteromers with ACKR4.

    Alternative splice isoforms for CXCR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXCR3 Gene

Proteomics data for CXCR3 Gene at MOPED

Post-translational modifications for CXCR3 Gene

Other Protein References for CXCR3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCR3 Gene

Domains for CXCR3 Gene

Gene Families for CXCR3 Gene

HGNC:
  • CD :CD molecules
  • CXCR :GPCR / Class A : Chemokine receptors : C-X-C motif
IUPHAR :

Suggested Antigen Peptide Sequences for CXCR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49682

UniProtKB/Swiss-Prot:

CXCR3_HUMAN :
  • P49682
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR3: view

Function for CXCR3 Gene

Molecular function for CXCR3 Gene

GENATLAS Biochemistry: chemokine receptor 3 for the interferon gamma inducible proteins INP10,MIG mediating a rapid induction of effector in T lymphocytes,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
UniProtKB/Swiss-Prot Function: Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.
UniProtKB/Swiss-Prot Function: Isoform 3: Mediates the activity of CXCL11

Gene Ontology (GO) - Molecular Function for CXCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 12782716
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 9064356
GO:0016494 C-X-C chemokine receptor activity IEA --
GO:0019956 chemokine binding IPI 11554781
genes like me logo Genes that share ontologies with CXCR3: view
genes like me logo Genes that share phenotypes with CXCR3: view

Animal Models for CXCR3 Gene

MGI Knock Outs for CXCR3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CXCR3 Gene

Localization for CXCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR3 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCR3 Gene COMPARTMENTS Subcellular localization image for CXCR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CXCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10903743
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9064356
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface --
genes like me logo Genes that share ontologies with CXCR3: view

Pathways for CXCR3 Gene

genes like me logo Genes that share pathways with CXCR3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CXCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001937 negative regulation of endothelial cell proliferation IDA 12782716
GO:0002685 regulation of leukocyte migration IEA --
GO:0006915 apoptotic process IEA --
GO:0006928 movement of cell or subcellular component TAS 10741397
genes like me logo Genes that share ontologies with CXCR3: view

Compounds for CXCR3 Gene

(17) IUPHAR Ligand for CXCR3 Gene

Ligand Type Action Affinity Pubmed IDs
CCL11 Antagonist Antagonist 10
CCL19 Agonist Agonist 9.1
NBI-74330 Antagonist Antagonist 8.8
CCL20 Agonist Full agonist 8.5
CCL5 Agonist Full agonist 8.2
CCL7 Agonist Full agonist 8.1
SDF-1alpha Agonist Agonist 7.9
duramycin Antagonist Antagonist 7
dioscin Antagonist Antagonist 6.3
hypoglaucin A Antagonist Antagonist 5.7
kallstroemin D Antagonist Antagonist 5.5
CXCL11 Antagonist Antagonist
CXCL10 Antagonist Antagonist
CXCL9 Antagonist Antagonist
CCL13 Agonist Agonist
[125I]CXCL11 Agonist Full agonist
[125I]CXCL10 Agonist Full agonist

(47) Novoseek inferred chemical compound relationships for CXCR3 Gene

Compound -log(P) Hits PubMed IDs
tarc 90.5 47
rantes 89.4 133
ccl3 79.3 10
mcp 1 65.7 5
groalpha 62.6 4
genes like me logo Genes that share compounds with CXCR3: view

Transcripts for CXCR3 Gene

mRNA/cDNA for CXCR3 Gene

(15) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCR3 Gene

Chemokine (C-X-C motif) receptor 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCR3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR3 Gene

No ASD Table

Relevant External Links for CXCR3 Gene

GeneLoc Exon Structure for
CXCR3
ECgene alternative splicing isoforms for
CXCR3

Expression for CXCR3 Gene

mRNA expression in normal human tissues for CXCR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCR3 Gene

This gene is overexpressed in Whole Blood (8.8), Spleen (7.7), and Small Intestine - Terminal Ileum (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CXCR3 Gene

SOURCE GeneReport for Unigene cluster for CXCR3 Gene Hs.198252

mRNA Expression by UniProt/SwissProt for CXCR3 Gene

P49682-CXCR3_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
genes like me logo Genes that share expressions with CXCR3: view

In Situ Assay Products

Orthologs for CXCR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCR3 35
  • 99.68 (n)
  • 100 (a)
CXCR3 36
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXCR3 35
  • 87.33 (n)
  • 87.33 (a)
CXCR3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXCR3 35
  • 85.25 (n)
  • 86.83 (a)
CXCR3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcr3 35
  • 83.06 (n)
  • 86.54 (a)
Cxcr3 16
Cxcr3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcr3 35
  • 83.79 (n)
  • 86.54 (a)
lizard
(Anolis carolinensis)
Reptilia CXCR3 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485636 35
  • 53.56 (n)
  • 49.09 (a)
zebrafish
(Danio rerio)
Actinopterygii cxcr3.1 35
  • 55.38 (n)
  • 45.45 (a)
cxcr3.1 36
  • 40 (a)
OneToOne
Species with no ortholog for CXCR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCR3 Gene

ENSEMBL:
Gene Tree for CXCR3 (if available)
TreeFam:
Gene Tree for CXCR3 (if available)

Paralogs for CXCR3 Gene

genes like me logo Genes that share paralogs with CXCR3: view

Variants for CXCR3 Gene

Sequence variations from dbSNP and Humsavar for CXCR3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2230438 -- 71,616,761(-) GCCCA(C/T)ATCCT reference, synonymous-codon, intron-variant
rs2280964 -- 71,618,204(+) CCCCC(C/T)CCATT intron-variant
rs3091306 -- 71,618,263(-) TTGGC(A/C)ACTGA intron-variant
rs3761523 -- 71,619,035(-) ctttt(A/T)ttatt upstream-variant-2KB
rs5981122 -- 71,620,300(+) GGCCA(C/G)AGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXCR3 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407
nsv6954 CNV Insertion 18451855

Relevant External Links for CXCR3 Gene

HapMap Linkage Disequilibrium report
CXCR3
Human Gene Mutation Database (HGMD)
CXCR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR3 Gene

Disorders for CXCR3 Gene

(96) Novoseek inferred disease relationships for CXCR3 Gene

Disease -log(P) Hits PubMed IDs
inflammation 63.6 39
multiple sclerosis 56 17
fibrosis idiopathic pulmonary 54.7 5
sarcoidosis pulmonary 52.4 6
mycosis fungoides 48.8 5

Relevant External Links for CXCR3

Genetic Association Database (GAD)
CXCR3
Human Genome Epidemiology (HuGE) Navigator
CXCR3
genes like me logo Genes that share disorders with CXCR3: view

No data available for UniProtKB/Swiss-Prot for CXCR3 Gene

Publications for CXCR3 Gene

  1. Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PMID: 11196695) Kato H. … Tokunaga K. (Genes Immun. 2000) 3 4 23 48
  2. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (PMID: 9625760) Cole K.E. … Neote K. (J. Exp. Med. 1998) 3 4 23
  3. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. (PMID: 12782716) Lasagni L. … Romagnani P. (J. Exp. Med. 2003) 3 4 23
  4. CXCR3 polymorphisms associated with risk of asthma. (PMID: 16043121) Cheong H.S. … Oh B. (Biochem. Biophys. Res. Commun. 2005) 3 23 48
  5. CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. (PMID: 16847335) Colvin R.A. … Luster A.D. (Mol. Cell. Biol. 2006) 3 4 23

Products for CXCR3 Gene

Sources for CXCR3 Gene

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