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Aliases for CXCR3 Gene

Aliases for CXCR3 Gene

  • C-X-C Motif Chemokine Receptor 3 2 3 5
  • G Protein-Coupled Receptor 9 2 3 4
  • Interferon-Inducible Protein 10 Receptor 3 4
  • Chemokine (C-X-C Motif) Receptor 3 2 3
  • IP-10 Receptor 3 4
  • CKR-L2 3 4
  • GPR9 3 4
  • C-X-C Chemokine Receptor Type 3 3
  • Chemokine Receptor 3 3
  • CD183 Antigen 4
  • Mig Receptor 3
  • CMKAR3 3
  • IP10-R 3
  • CXC-R3 4
  • CXCR-3 4
  • CD182 3
  • CD183 3
  • Mig-R 3
  • MigR 3

External Ids for CXCR3 Gene

Previous HGNC Symbols for CXCR3 Gene

  • GPR9

Previous GeneCards Identifiers for CXCR3 Gene

  • GC0XM067009
  • GC0XM068313
  • GC0XM069068
  • GC0XM069702
  • GC0XM070618
  • GC0XM070752
  • GC0XM064650
  • GC0XM070835

Summaries for CXCR3 Gene

Entrez Gene Summary for CXCR3 Gene

  • This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

GeneCards Summary for CXCR3 Gene

CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CXCR5.

UniProtKB/Swiss-Prot for CXCR3 Gene

  • Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.

  • Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.

  • Isoform 3: Mediates the activity of CXCL11.

Tocris Summary for CXCR3 Gene

  • Chemokine CXC receptors (CXCRs) predominantly recognize CXC chemokines. CXC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being separated by a single amino acid. There are six chemokine CXC receptors.

Gene Wiki entry for CXCR3 Gene

Additional gene information for CXCR3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR3 Gene

Genomics for CXCR3 Gene

GeneHancer (GH) Regulatory Elements for CXCR3 Gene

Promoters and enhancers for CXCR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI071615 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.6 +0.3 311 5.9 PKNOX1 BMI1 BATF IRF4 RAD21 ZNF766 ATF7 ETV6 BCLAF1 IKZF2 CXCR3 OGT TAF1 GCNA
GH0XI071621 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 7.9 -5.2 -5170 4.4 BMI1 BATF KLF5 IRF4 ZBTB40 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 GC0XM071623 CXCR3 OGT TAF1
GH0XI072094 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -476.8 -476762 1.5 PKNOX1 MXI1 RFX1 SOX6 MAX ELF1 BMI1 ZNF585B MYNN RCOR1 ZMYM3 RTL5 HDAC8 CXCR3 PIR32507 PIR42075 NHSL2
GH0XI071565 Enhancer 0.5 dbSUPER 12.6 +52.2 52239 1.3 PAF1 NFIC NFIB ZSCAN5C ZBTB40 CXCR3 TAF1 GCNA OGT
GH0XI071195 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE 4.2 +421.1 421095 3.5 ELF1 ATF2 IRF4 POLR2A IKZF1 GABPB1 NBN HMBOX1 ZNF143 ATF7 ENSG00000228427 IL2RG CXCR3 MED12 TAF1 NLGN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CXCR3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXCR3 gene promoter:

Genomic Locations for CXCR3 Gene

Genomic Locations for CXCR3 Gene
chrX:71,615,914-71,618,517
(GRCh38/hg38)
Size:
2,604 bases
Orientation:
Minus strand
chrX:70,835,766-70,838,367
(GRCh37/hg19)

Genomic View for CXCR3 Gene

Genes around CXCR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR3 Gene

Proteins for CXCR3 Gene

  • Protein details for CXCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49682-CXCR3_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 3
    Protein Accession:
    P49682
    Secondary Accessions:
    • B2R982
    • O15185
    • Q7Z710
    • Q9P2T4
    • Q9P2T5

    Protein attributes for CXCR3 Gene

    Size:
    368 amino acids
    Molecular mass:
    40660 Da
    Quaternary structure:
    • Homomer. Forms heteromers with ACKR4.

    Alternative splice isoforms for CXCR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXCR3 Gene

Post-translational modifications for CXCR3 Gene

Other Protein References for CXCR3 Gene

Antibody Products

  • Abcam antibodies for CXCR3

No data available for DME Specific Peptides for CXCR3 Gene

Domains & Families for CXCR3 Gene

Gene Families for CXCR3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CXCR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49682

UniProtKB/Swiss-Prot:

CXCR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR3: view

Function for CXCR3 Gene

Molecular function for CXCR3 Gene

GENATLAS Biochemistry:
chemokine receptor 3 for the interferon gamma inducible proteins INP10,MIG mediating a rapid induction of effector in T lymphocytes,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
UniProtKB/Swiss-Prot Function:
Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.
UniProtKB/Swiss-Prot Function:
Isoform 3: Mediates the activity of CXCL11.

Gene Ontology (GO) - Molecular Function for CXCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004950 chemokine receptor activity TAS 9064356
GO:0016494 C-X-C chemokine receptor activity IEA --
GO:0019956 chemokine binding IPI 11554781
genes like me logo Genes that share ontologies with CXCR3: view
genes like me logo Genes that share phenotypes with CXCR3: view

Animal Models for CXCR3 Gene

MGI Knock Outs for CXCR3:

Animal Model Products

Clone Products

  • Addgene plasmids for CXCR3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CXCR3 Gene

Localization for CXCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR3 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CXCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10903743
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9064356
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with CXCR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCR3 Gene

Pathways & Interactions for CXCR3 Gene

genes like me logo Genes that share pathways with CXCR3: view

Gene Ontology (GO) - Biological Process for CXCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0002685 regulation of leukocyte migration IEA --
GO:0006915 apoptotic process IEA --
GO:0006928 movement of cell or subcellular component TAS 10741397
GO:0006935 chemotaxis TAS 10903763
genes like me logo Genes that share ontologies with CXCR3: view

No data available for SIGNOR curated interactions for CXCR3 Gene

Drugs & Compounds for CXCR3 Gene

(50) Drugs for CXCR3 Gene - From: ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NBI-74330 Pharma Antagonist CXCR3 antagonist 0
CCL11 Pharma Antagonist 0
CCL13 Pharma Agonist 0
CCL19 Pharma Agonist 0
CCL20 Pharma Full agonist, Agonist 0

(24) Additional Compounds for CXCR3 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CXCL10
Full agonist, Agonist
[<sup>125</sup>I]CXCL11
Full agonist, Agonist
SDF-1alpha
Agonist

(8) ApexBio Compounds for CXCR3 Gene

Compound Action Cas Number
(±)-AMG 487 CXCR3 antagonist
AMG 487 CXCR3 antagonist,potent and selective 473719-41-4
NBI-74330 CXCR3 antagonist 855527-92-3
Plerixafor 8HCl (AMD3100 8HCl) CXCR4 antagonist 155148-31-5
SCH 546738 CXCR antagonist 906805-42-3
SRT3109 1204707-71-0
UNBS 5162 A pan-antagonist of CXCL chemokines 956590-23-1
WZ811 Competitive CXR4 antagonist,highly potent 55778-02-4
genes like me logo Genes that share compounds with CXCR3: view

Drug Products

Transcripts for CXCR3 Gene

mRNA/cDNA for CXCR3 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCR3 Gene

Chemokine (C-X-C motif) receptor 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for CXCR3

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR3 Gene

No ASD Table

Relevant External Links for CXCR3 Gene

GeneLoc Exon Structure for
CXCR3
ECgene alternative splicing isoforms for
CXCR3

Expression for CXCR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCR3 Gene

This gene is overexpressed in Whole Blood (x8.8), Spleen (x7.7), and Small Intestine - Terminal Ileum (x5.2).

Protein differential expression in normal tissues from HIPED for CXCR3 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCR3 Gene



Protein tissue co-expression partners for CXCR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CXCR3 Gene:

CXCR3

SOURCE GeneReport for Unigene cluster for CXCR3 Gene:

Hs.198252

mRNA Expression by UniProt/SwissProt for CXCR3 Gene:

P49682-CXCR3_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).

Evidence on tissue expression from TISSUES for CXCR3 Gene

  • Blood(4.6)
  • Intestine(4.4)
  • Lung(4.4)
  • Nervous system(4.4)
  • Heart(4.3)
  • Lymph node(2.9)
  • Spleen(2.7)
  • Bone marrow(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with CXCR3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCR3 Gene

Orthologs for CXCR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCR3 33 34
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia CXCR3 33 34
  • 87.33 (n)
dog
(Canis familiaris)
Mammalia CXCR3 33 34
  • 85.25 (n)
rat
(Rattus norvegicus)
Mammalia Cxcr3 33
  • 83.79 (n)
mouse
(Mus musculus)
Mammalia Cxcr3 33 16 34
  • 83.06 (n)
lizard
(Anolis carolinensis)
Reptilia CXCR3 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485636 33
  • 53.56 (n)
zebrafish
(Danio rerio)
Actinopterygii cxcr3.1 33 34
  • 55.38 (n)
Species where no ortholog for CXCR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCR3 Gene

ENSEMBL:
Gene Tree for CXCR3 (if available)
TreeFam:
Gene Tree for CXCR3 (if available)

Paralogs for CXCR3 Gene

genes like me logo Genes that share paralogs with CXCR3: view

Variants for CXCR3 Gene

Sequence variations from dbSNP and Humsavar for CXCR3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1003951195 -- 71,619,088(-) C/T upstream_transcript_variant
rs1004086764 -- 71,618,592(-) C/G upstream_transcript_variant
rs1004470882 -- 71,617,658(-) T/C 5_prime_UTR_variant, intron_variant
rs1005095693 -- 71,615,500(-) G/T downstream_transcript_variant
rs1005472899 -- 71,620,010(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXCR3 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv33082 CNV loss 17666407
nsv6954 CNV insertion 18451855

Variation tolerance for CXCR3 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCR3 Gene

Human Gene Mutation Database (HGMD)
CXCR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR3 Gene

Disorders for CXCR3 Gene

MalaCards: The human disease database

(51) MalaCards diseases for CXCR3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cutaneous lupus erythematosus
  • lupus erythematosus, cutaneous
pulmonary sarcoidosis
  • lung sarcoidosis
intermediate uveitis
  • chronic cyclitis
allergic contact dermatitis
  • contact dermatitis, allergic
mycosis fungoides
  • mf
- elite association - COSMIC cancer census association via MalaCards
Search CXCR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR3 Gene

Publications for CXCR3 Gene

  1. CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. (PMID: 16847335) Colvin RA … Luster AD (Molecular and cellular biology 2006) 3 4 22 58
  2. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. (PMID: 12782716) Lasagni L … Romagnani P (The Journal of experimental medicine 2003) 3 4 22 58
  3. Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3. (PMID: 11196695) Kato H … Tokunaga K (Genes and immunity 2000) 3 4 44 58
  4. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (PMID: 9625760) Cole KE … Neote K (The Journal of experimental medicine 1998) 3 4 22 58
  5. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PMID: 9064356) Loetscher M … Moser B (The Journal of experimental medicine 1996) 2 3 4 58

Products for CXCR3 Gene

  • Addgene plasmids for CXCR3

Sources for CXCR3 Gene

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