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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCR3 Gene

protein-coding   GIFtS: 65
GCID: GC0XM070835

Chemokine (C-X-C Motif) Receptor 3

(Previous name: G protein-coupled receptor 9)
(Previous symbol: GPR9)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Receptor 31 2     CMKAR32
GPR91 2 3 5     IP10-R2
G Protein-Coupled Receptor 91 2 3     Mig-R2
Interferon-Inducible Protein 10 Receptor2 3     MigR2
CKR-L22 3     C-X-C Chemokine Receptor Type 32
CXC-R32 3     Chemokine (C-X-C) Receptor 32
CXCR-32 3     IP10 Receptor2
IP-10 Receptor2 3     Mig Receptor2
CD1822 5     CD183 Antigen3
CD1832     

External Ids:    HGNC: 45401   Entrez Gene: 28332   Ensembl: ENSG000001868107   OMIM: 3005745   UniProtKB: P496823   

Export aliases for CXCR3 gene to outside databases

Previous GC identifers: GC0XM067009 GC0XM068313 GC0XM069068 GC0XM069702 GC0XM070618 GC0XM070752 GC0XM064650


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CXCR3 Gene:
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine
induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC
(interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses
that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic
migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). (provided by
RefSeq, Jun 2011)

GeneCards Summary for CXCR3 Gene: 
CXCR3 (chemokine (C-X-C motif) receptor 3) is a protein-coding gene. Diseases associated with CXCR3 include lichen planus, and complex regional pain syndrome type 1, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Peptide GPCRs. GO annotations related to this gene include chemokine binding and chemokine receptor activity. An important paralog of this gene is CCR6.

UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682
Function: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC)
Function: Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and
CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to
activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer
cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis
Function: Isoform 3 mediates the activity of CXCL11

Gene Wiki entry for CXCR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011669.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCR3 gene promoter:
         E2F-3a   E2F-4   E2F-5   Lmo2   E2F-2   E2F-1   E2F   PPAR-gamma2   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13

CXCR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCR3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM070835:  view genomic region     (about GC identifiers)

Start:
70,835,766 bp from pter      End:
70,838,367 bp from pter
Size:
2,602 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682 (See protein sequence)
Recommended Name: C-X-C chemokine receptor type 3  
Size: 368 amino acids; 40660 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAB02143.1; Type=Erroneous initiation;
Secondary accessions: B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5
Alternative splicing: 3 isoforms:  P49682-1   P49682-2   P49682-3   (Due to exon skipping)

Explore the universe of human proteins at neXtProt for CXCR3: NX_P49682

Explore proteomics data for CXCR3 at MOPED 

Post-translational modifications:

  • UniProtKB: Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction
  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49682

  • CXCR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXCR3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001136269.1  NP_001495.1  

    ENSEMBL proteins: 
     ENSP00000362795   ENSP00000362797  
    Reactome Protein details: P49682
    Human Recombinant Protein Products for CXCR3: 
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    OriGene Protein Over-expression Lysate for CXCR3
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    Novus Biologicals CXCR3 Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CXCR3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10903743
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9064356
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane ----

    CXCR3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    CXCR: GPCR / Class A : Chemokine receptors : C-X-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CXCR3 
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004070 Chemokine_CXCR3
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P49682

    ProtoNet protein and cluster: P49682

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB004070 C-X-C chemokine receptor type 3 signature


    UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CXCR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCR3_HUMAN, P49682
    Function: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC)
    Function: Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and
    CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to
    activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer
    cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis
    Function: Isoform 3 mediates the activity of CXCL11

         Genatlas biochemistry entry for CXCR3:
    chemokine receptor 3 for the interferon gamma inducible proteins INP10,MIG mediating a rapid induction of effector
    in T lymphocytes,G protein coupled receptor superfamily

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS9064356
    GO:0016494C-X-C chemokine receptor activity IEA--
    GO:0019956chemokine binding IPI11554781
    GO:0019957C-C chemokine binding ----
         
    CXCR3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CXCR3:
     Increased cell number in G1, a  Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cxcr3):
     cardiovascular system  cellular  homeostasis/metabolism  immune system  mortality/aging 
     normal  renal/urinary system  respiratory system  tumorigenesis 

    CXCR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CXCR3: Cxcr3tm1Wwh Cxcr3tm1Raks

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCR3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCR3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCR3 

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    SwitchGear 3'UTR luciferase reporter plasmidCXCR3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CXCR3 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    3PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    4Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CXCR3
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCR3 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    4 BioSystems Pathways for CXCR3
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    CXCR3-mediated signaling events
    Peptide GPCRs


    5/8        Reactome Pathways for CXCR3 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    2         Kegg Pathways  (Kegg details for CXCR3):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CXCR3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for CXCR3 (P496823 ENSP000003627954) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCL11O146253, ENSP000003068844I2D: score=3 STRING: ENSP00000306884
    CXCL13O439273, ENSP000002867584I2D: score=3 STRING: ENSP00000286758
    CXCL9Q073253, ENSP000003549014I2D: score=3 STRING: ENSP00000354901
    PF4P027763, ENSP000002960294I2D: score=3 STRING: ENSP00000296029
    CCL11P516713, ENSP000003022344I2D: score=1 STRING: ENSP00000302234
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0002685regulation of leukocyte migration IEA--
    GO:0006915apoptotic process IEA--
    GO:0006928cellular component movement TAS10741397
    GO:0006935chemotaxis TAS10903763

    CXCR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCR3

    10/17 IUPHAR Ligands for CXCR3 (CXCR3) (see all 17)    About this table 
    LigandTypeActionAffinityPubmed IDs
    CXCL11
    AgonistFull agonist10.4 - 10.515761110
    CXCL10
    AgonistFull agonist7.8 - 9.89660793 15761110
    NBI-74330
    AntagonistAntagonist8.3 - 8.815761110
    CXCL9
    AgonistFull agonist7.3 - 8.39660793 15761110
    CCL13
    AgonistFull agonist7.29660793
    duramycin
    AntagonistAntagonist715789559
    CCL20
    AgonistFull agonist6.89660793
    CCL5
    AgonistFull agonist6.49660793
    SDF-1α
    AgonistFull agonist6.49660793
    dioscin
    AntagonistAntagonist6.315789559

    10/47 Novoseek inferred chemical compound relationships for CXCR3 gene (see all 47)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 90.5 53 18276722 (4), 11920617 (3), 12911508 (2), 15944327 (2) (see all 35)
    rantes 89.4 168 9856808 (3), 7531729 (3), 16239601 (3), 15126779 (3) (see all 99)
    ccl3 79.3 11 20205697 (2), 19906920 (1), 15848520 (1), 17640964 (1) (see all 9)
    mcp 1 65.7 5 20205697 (2), 11683586 (1), 20332253 (1), 17993576 (1)
    groalpha 62.6 4 15044249 (2), 19819721 (1), 11422029 (1)
    ccl4 54.9 9 19265171 (1), 15848520 (1), 12960247 (1), 15591886 (1) (see all 7)
    larc 39.4 2 10934220 (1)
    dimethyl fumarate 38.7 3 15663561 (1), 11422029 (1)
    vegf 38 28 16484616 (5), 20137269 (3), 12788875 (2), 16518330 (2) (see all 17)
    ifn-alpha 22.5 2 15880822 (1), 16571725 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CXCR3 gene (2 alternative transcripts): 
    NM_001142797.1  NM_001504.1  

    Unigene Cluster for CXCR3:

    Chemokine (C-X-C motif) receptor 3
    Hs.198252  [show with all ESTs]
    Unigene Representative Sequence: NM_001142797
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373691(uc011mpx.2) ENST00000373693(uc004eaf.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCR3

    Additional mRNA sequence: 

    AF469635.1 AK313679.1 AY242128.1 BC034403.1 X95876.1 

    3 DOTS entries:

    DT.75149539  DT.100746773  DT.100746772 

    15 AceView cDNA sequences:

    AJ346279 NM_001504 BI768435 AJ573366 BQ053710 X95876 BP340425 BC034403 
    AY242128 AF469635 BI821147 BI911171 BQ052726 CD246172 AI587350 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCR3 expression in normal human tissues (normalized intensities)      CXCR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCCCAAGA
    CXCR3 Expression
    About this image


    CXCR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
             cd3+ t cells   
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
     
     Pancreas (Endocrine System)

    See CXCR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCR3

    SOURCE GeneReport for Unigene cluster: Hs.198252

    UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682
    Tissue specificity: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle.
    Isoform 1 is also expressed in placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCR3 (see all 9): 
              Multiple Sclerosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CXCR3 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcr31 , 5 chemokine (C-X-C motif) receptor 31, 5 83.06(n)1
    86.54(a)1
      X (44.58 cM)5
    127661  NM_009910.21  NP_034040.11 
     1017315355 
    lizard
    (Anolis carolinensis)
    Reptilia CXCR36
    chemokine (C-X-C motif) receptor 3
    46(a)
    1 ↔ 1
    GL343868.1(20789-28934)
    zebrafish
    (Danio rerio)
    Actinopterygii cxcr3.11 chemokine (C-X-C motif) receptor 3.1 54.66(n)
    44.64(a)
      654692  NM_001089430.2  NP_001082899.2 


    ENSEMBL Gene Tree for CXCR3 (if available)
    TreeFam Gene Tree for CXCR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCR3 gene
    CCR62  CCR52  CXCR62  ACKR42  XCR12  CCR92  CCRL22  CCR72  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/32 SIMAP similar genes for CXCR3 using alignment to 1 protein entry:     CXCR3_HUMAN(see all similar genes):
    CCR7    CCR5    CCBP2    CXCR4    CCR2    BLR1
    CCR1    CCR3    CCR4    CXCR1    CXCR2    CXCR5
    IL8RB    CCR6    CCRL1    CXCR6    AGTR1    CX3CR1

    CXCR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/75 SNPs in CXCR3 are shown (see all 75)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0162414
    ----see VAR_0162412 A T mis40--------
    rs1882263381,2
    --70841835(+) CCTTAG/TGCCTG 2 -- ds50010--------
    rs1490884841,2
    --70841880(+) CTTCCC/TAAATG 2 -- ds50010--------
    rs1925662731,2
    --70841961(+) GGTTTC/TGCTAG 2 -- ds50010--------
    rs1847875431,2
    --70842226(+) TGGAGC/GCCAGG 2 -- ds50010--------
    rs1900353761,2
    --70842261(+) CACGAA/CCATGC 2 -- ds50010--------
    rs1812459001,2
    --70842444(+) CACTTA/GGGGAA 2 -- ut310--------
    rs1997144781,2
    C--70842835(+) AGCATA/CCACAT 4 W C mis10--------
    rs2003525031,2
    --70842848(+) GCTCCC/TGGAAC 4 Q R mis10--------
    rs1474344661,2
    C,F--70842853(+) CGGAAC/GTTGAC 4 N K mis11Minor allele frequency- G:0.00NA 4514

    HapMap Linkage Disequilibrium report for CXCR3 (70835766 - 70838367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CXCR3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6954CNV Insertion18451855
    esv33082CNV Loss17666407
    esv1584074OTHER Inversion17803354


    Human Gene Mutation Database (HGMD): CXCR3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300574    OMIM disorders: --

    20/168 diseases for CXCR3 (see all 168):    About MalaCards
    lichen planus    complex regional pain syndrome type 1    intermediate uveitis    viral meningitis
    chromoblastomycosis    alk-negative anaplastic large cell lymphoma    mycosis fungoides    lupus nephritis
    peripheral t-cell lymphoma    paragonimiasis    inclusion body myositis    periapical granuloma
    chronic eosinophilic pneumonia    lymphomatoid papulosis    uveitis    pulmonary sarcoidosis
    proliferative glomerulonephritis    malt lymphoma    central nervous system disease    bronchiolitis obliterans

    4 diseases from the University of Copenhagen DISEASES database for CXCR3:
    Multiple sclerosis     Hypersensitivity reaction type II disease     Dermatitis     Rheumatoid arthritis

    CXCR3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for CXCR3 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 63.6 46 11786428 (2), 15108349 (2), 15155273 (2), 12953097 (2) (see all 32)
    multiple sclerosis 56 18 11867072 (2), 16709257 (1), 19225413 (1), 16899302 (1) (see all 16)
    fibrosis idiopathic pulmonary 54.7 5 20137269 (2), 16085216 (2), 17137778 (1)
    sarcoidosis pulmonary 52.4 7 17052298 (2), 19386686 (1), 11390417 (1), 9834133 (1) (see all 5)
    mycosis fungoides 48.8 5 14708605 (2), 16713487 (1), 16931956 (1), 11242798 (1)
    lupus erythematosus cutaneous 48.6 1 18280341 (1)
    bronchoalveolar lavage fluid 48.2 8 19842835 (1), 19878731 (1), 16085216 (1), 18644457 (1) (see all 8)
    necrosis 43.9 35 9354680 (4), 8943014 (3), 19095263 (2), 16299288 (1) (see all 27)
    lymphomatoid papulosis 42.5 2 16931956 (1), 11242798 (1)
    lymphoma t-cell 42 7 15328188 (1), 16931956 (1), 19887486 (1), 10887135 (1) (see all 7)

    Genetic Association Database (GAD): CXCR3
    Human Genome Epidemiology (HuGE) Navigator: CXCR3 (9 documents)

    Export disorders for CXCR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCR3 gene, integrated from 9 sources (see all 888):
    (articles sorted by number of sources associating them with CXCR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PubMed id 11196695)1, 2, 4, 9 Kato H.... Tokunaga K. (2000)
    2. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PubMed id 9064356)1, 2, 3 Loetscher M.... Moser B. (1996)
    3. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PubMed id 8666380)1, 2, 3 Marchese A.... Docherty J.M. (1995)
    4. CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. (PubMed id 16847335)1, 2, 9 Colvin R.A....Luster A.D. (2006)
    5. CXCR3 polymorphisms associated with risk of asthma. (PubMed id 16043121)1, 4, 9 Cheong H.S....Oh B. (2005)
    6. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. (PubMed id 12782716)1, 2, 9 Lasagni L.... Romagnani P. (2003)
    7. Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B. (PubMed id 18291705)1, 2, 9 Petrai I....Marra F. (2008)
    8. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (PubMed id 9625760)1, 2, 9 Cole K.E....Neote K. (1998)
    9. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)
    10. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2833 HGNC: 4540 AceView: CXCR3 Ensembl:ENSG00000186810 euGenes: HUgn2833
    ECgene: CXCR3 Kegg: 2833 H-InvDB: CXCR3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCR3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCR3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXCR3 gene:
    Search GeneIP for patents involving CXCR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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