CXCR3 Gene
protein-coding GIFtS: 64
GCID: GC0XM070835
|
|
chemokine (C-X-C motif) receptor 3(Previous name: G protein-coupled receptor 9 )
(Previous symbol: GPR9)
| |
Aliases
for CXCR3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chemokine (C-X-C Motif) Receptor 31 2 | | CXCR-32 3 | | GPR91 2 3 5 | | IP-10 Receptor2 3 | | CKR-L21 2 3 | | CD1822 5 | | G Protein-Coupled Receptor 91 2 3 | | Mig-R2 | | CD1831 2 | | C-X-C Chemokine Receptor Type 32 | | CMKAR31 2 | | Chemokine (C-X-C) Receptor 32 | | IP10-R1 2 | | IP10 Receptor2 | | MigR1 2 | | Mig Receptor2 | | Interferon-Inducible Protein 10 Receptor2 3 | | CD183 Antigen3 | | CXC-R32 3 | | |
Export aliases for CXCR3 gene to outside databasesPrevious GC identifers: GC0XM067009 GC0XM068313 GC0XM069068 GC0XM069702 GC0XM070618 GC0XM070752 GC0XM064650 |
Summaries
for CXCR3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CXCR3:
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokineinduced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible Tcell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved inleukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternativelyspliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B)shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). (provided by RefSeq, Jun 2011)
UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682Function: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC)Function: Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 onthe growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to activation ofthe p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulatesexpression of the anti-apoptotic protein HMOX1 and promotes apoptosisFunction: Isoform 3 mediates the activity of CXCL11
Gene Wiki entry for CXCR3
|
Genomic Views
for CXCR3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CXCR3 gene promoter:
E2F-3a E2F-4 E2F-5 Lmo2 E2F-2 E2F-1 E2F PPAR-gamma2 NF-kappaB1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CXCR3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCR3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13CXCR3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM070835: view genomic region
(about GC identifiers)
Start:
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70,835,766 bp from pter |
End:
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70,838,367 bp from pter |
Size:
|
2,602 bases |
Orientation:
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minus strand |
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Proteins
for CXCR3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682 (See
protein sequence)Recommended Name: C-X-C chemokine receptor type 3 Size: 368 amino acids; 40660 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAB02143.1; Type=Erroneous initiation;
Secondary accessions: B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5Alternative splicing: 3 isoforms: P49682-1 P49682-2 P49682-3 (Due to exon skipping)Explore the universe of human proteins at neXtProt for CXCR3: NX_P49682
Post-translational modifications:
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction1
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49682
CXCR3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001136269.1 NP_001495.1
ENSEMBL proteins: ENSP00000362795 ENSP00000362797 Reactome Protein details: P49682
Human Recombinant Protein Products for CXCR3:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CXCR3 for ontologies About GeneDecksing
CXCR3 Antibody Products:
Assay Products for CXCR3: |
Protein
Domains /
Families
for CXCR3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CXCR3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P49682ProtoNet protein and cluster: P49682 2 Blocks protein families: IPB000355 Chemokine receptor signature IPB004070 C-X-C chemokine receptor type 3 signature
UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for CXCR3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CXCR3_HUMAN, P49682Function: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC)Function: Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 onthe growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to activation ofthe p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulatesexpression of the anti-apoptotic protein HMOX1 and promotes apoptosisFunction: Isoform 3 mediates the activity of CXCL11 Genatlas biochemistry entry for CXCR3:chemokine receptor 3 for the interferon gamma inducible proteins INP10,MIG mediating a rapid induction of effector in Tlymphocytes,G protein coupled receptor superfamily
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CXCR3 for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for CXCR3:
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Cxcr3):
CXCR3 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for CXCR3: Cxcr3tm1Wwh Cxcr3tm1Raks
Clone
Products: |  | EMD Millipore Clones for the Expression of CXCR3 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCR3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCR3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CXCR3 (NM_001504) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXCR3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR3 |
|
Pathways & Interactions
for CXCR3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Akt Signaling | | | 3 | Signaling by GPCR | | | 4 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | | | 5 | Chemokine Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CXCR3
5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCR3 (see all 8)
4  BioSystems Pathways for CXCR3
5/8 
Reactome Pathways for CXCR3 (see all 8)
2 
Kegg Pathways (Kegg details for CXCR3):
CXCR3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCR3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/65 Interacting proteins for CXCR3 (P496823 ENSP000003627954) via UniProtKB, MINT, STRING, and/or I2D (see all 65)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
CXCR3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CXCR3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CXCR3 for compounds About GeneDecksing
 Browse Tocris compounds for CXCR3
10/47 Novoseek chemical compound relationships for CXCR3 gene (see all 47) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tarc |
90.5 |
53 |
18276722 (4), 11920617 (3), 12911508 (2), 15944327 (2) (see all 35) |
| rantes |
89.4 |
168 |
9856808 (3), 7531729 (3), 16239601 (3), 15126779 (3) (see all 99) |
| ccl3 |
79.3 |
11 |
20205697 (2), 19906920 (1), 15848520 (1), 17640964 (1) (see all 9) |
| mcp 1 |
65.7 |
5 |
20205697 (2), 11683586 (1), 20332253 (1), 17993576 (1) |
| groalpha |
62.6 |
4 |
15044249 (2), 19819721 (1), 11422029 (1) |
| ccl4 |
54.9 |
9 |
19265171 (1), 15848520 (1), 12960247 (1), 15591886 (1) (see all 7) |
| larc |
39.4 |
2 |
10934220 (1) |
| dimethyl fumarate |
38.7 |
3 |
15663561 (1), 11422029 (1) |
| vegf |
38 |
28 |
16484616 (5), 20137269 (3), 12788875 (2), 16518330 (2) (see all 17) |
| ifn-alpha |
22.5 |
2 |
15880822 (1), 16571725 (1) |
Search CenterWatch for drugs/clinical trials and news about CXCR3
|
Transcripts
for CXCR3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CXCR3 gene (2 alternative transcripts): NM_001142797.1 NM_001504.1 Unigene Cluster for CXCR3: Chemokine (C-X-C motif) receptor 3 Hs.198252 [show with all ESTs]Unigene Representative Sequence: NM_0011427972 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373691(uc011mpx.2) ENST00000373693(uc004eaf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCR3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCR3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CXCR3 (NM_001504) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXCR3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR3 |
Additional cDNA sequence: AF469635.1 AK313679.1 AY242128.1 BC034403.1 X95876.1 3 DOTS entries: DT.75149539 DT.100746773 DT.100746772 15 AceView cDNA sequences: NM_001504 BC034403 BQ053710 AY242128 BI768435 X95876 AJ573366 BP340425 AJ346279 AF469635 BI821147 BI911171 BQ052726 CD246172 AI587350
GeneLoc Exon Structure
|
Expression
for CXCR3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CXCR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCCCAAGA
About this image
See CXCR3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXCR3
SOURCE GeneReport for Unigene cluster: Hs.198252
UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682Tissue specificity: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1is also expressed in placenta
SABiosciences Expression via Pathway-Focused PCR Arrays including CXCR3 (see all 9):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCR3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCR3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR3 |
Orthologs
for CXCR3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CXCR3 gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
CXCR36 |
-- |
44(a) |
1 ↔ 1 |
GL343868.1(23095-24207) |
zebrafish
(Danio rerio) |
Actinopterygii |
cxcr3.11 |
chemokine (C-X-C motif) receptor 3.1 |
54.66(n)
44.64(a) |
|
654692 NM_001089430.2 NP_001082899.2 |
ENSEMBL Gene Tree for CXCR3 (if available)
TreeFam Gene Tree for CXCR3 (if available) |
Paralogs
for CXCR3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CXCR3 gene
- CCR62 CCR52 CXCR62 XCR12 CCR92 CCBP22 CCRL22 CCR72
- CX3CR12 CCR82 CXCR22 CCRL12 CCR42 CXCR12 CCR12 CCR22
- CXCR52 CCR102 CCR32 CXCR42
18/34 SIMAP similar genes for CXCR3 using alignment to 1 protein entry: CXCR3_HUMAN(see all similar genes):CCR7 CCR5 CCBP2 CXCR4 BLR1 CCR1
CCR3 CCR4 CXCR1 CXCR2 CXCR5 IL8RB
CCR2 CCR6 CCRL1 CXCR6 AGTR1 CX3CR1
CXCR3 for paralogs About GeneDecksing
|
Genomic Variants
for CXCR3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CXCR3 (70835766 - 70838367 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for CXCR3
1 CNV: 7797
7 Indels: 96748 83586 83588 96749 96750 96751 83587
Human Gene Mutation Database (HGMD): CXCR3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCR3 |
|
Disorders
/ Diseases
for CXCR3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CXCR3 for disorders About GeneDecksing
OMIM gene information: 300574
OMIM disorders: --
20/175  diseases for CXCR3 (see all 175): About MalaCardsinclusion body myositis lymphomatoid papulosis relapsing-remitting multiple sclerosis lichen planus
periapical granuloma toxic epidermal necrolysis stevens-johnson syndrome anaplastic large cell lymphoma
hypersensitivity reaction type ii disease complex regional pain syndrome mycosis fungoides graft versus host disease
nonspecific interstitial pneumonia renal clear cell carcinoma bronchiolitis obliterans central nervous system disease
allergic contact dermatitis contact dermatitis proliferative glomerulonephritis oral lichen planus
3 diseases from the University of Copenhagen DISEASES database for CXCR3:Multiple sclerosis Hypersensitivity reaction type II disease Dermatitis 10/96 Novoseek disease relationships for CXCR3 gene (see all 96) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
63.6 |
46 |
11786428 (2), 15108349 (2), 15155273 (2), 12953097 (2) (see all 32) |
| multiple sclerosis |
56 |
18 |
11867072 (2), 16709257 (1), 19225413 (1), 16899302 (1) (see all 16) |
| fibrosis idiopathic pulmonary |
54.7 |
5 |
20137269 (2), 16085216 (2), 17137778 (1) |
| sarcoidosis pulmonary |
52.4 |
7 |
17052298 (2), 19386686 (1), 11390417 (1), 9834133 (1) (see all 5) |
| mycosis fungoides |
48.8 |
5 |
14708605 (2), 16713487 (1), 16931956 (1), 11242798 (1) |
| lupus erythematosus cutaneous |
48.6 |
1 |
18280341 (1) |
| bronchoalveolar lavage fluid |
48.2 |
8 |
19842835 (1), 19878731 (1), 16085216 (1), 18644457 (1) (see all 8) |
| necrosis |
43.9 |
35 |
9354680 (4), 8943014 (3), 19095263 (2), 16299288 (1) (see all 27) |
| lymphomatoid papulosis |
42.5 |
2 |
16931956 (1), 11242798 (1) |
| lymphoma t-cell |
42 |
7 |
15328188 (1), 16931956 (1), 19887486 (1), 10887135 (1) (see all 7) |
Genetic Association Database (GAD): CXCR3
Human Genome Epidemiology (HuGE) Navigator: CXCR3 (9 documents)
Export disorders for CXCR3 gene to outside databases
|
Publications
for CXCR3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CXCR3 gene, integrated from 9 sources (see all 880):
(articles sorted by number of sources associating them with CXCR3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PubMed id 11196695)1, 2, 4, 9 Kato H.... Tokunaga K. (2000)
- Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PubMed id 9064356)1, 2, 3 Loetscher M.... Moser B. (1996)
- Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PubMed id 8666380)1, 2, 3 Marchese A.... Docherty J.M. (1995)
- CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. (PubMed id 16847335)1, 2, 9 Colvin R.A....Luster A.D. (2006)
- CXCR3 polymorphisms associated with risk of asthma. (PubMed id 16043121)1, 4, 9 Cheong H.S....Oh B. (2005)
- An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. (PubMed id 12782716)1, 2, 9 Lasagni L.... Romagnani P. (2003)
- Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B. (PubMed id 18291705)1, 2, 9 Petrai I....Marra F. (2008)
- Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (PubMed id 9625760)1, 2, 9 Cole K.E....Neote K. (1998)
- CXCR3-B can mediate growth-inhibitory signals in huma n renal cancer cells by down-regulating the expression of heme oxygenase-1. (PubMed id 20855888)1, 2 Datta D....Pal S. (2010)
- Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping. (PubMed id 15528361)1, 2 Ehlert J.E.... Strieter R.M. (2004)
|
External Searches for CXCR3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CXCR3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CXCR3 gene
(According to HUGE)
About This Section
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Specialized Databases showing CXCR3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for CXCR3 gene:
Search GeneIP for patents involving CXCR3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CXCR3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CXCR3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCR3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCR3 | | | OriGene Protein Over-expression Lysate for CXCR3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CXCR3 | | OriGene 3'-UTR Clone for CXCR3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCR3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCR3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CXCR3 | | OriGene Custom Protein Services for CXCR3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CXCR3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCR3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCR3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCR3 |
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| | | | Search Tocris compounds for CXCR3 |
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 | | | CXCR3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR3 |
|  |  |  |  | | | | ThermoFisher Antibody for CXCR3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR3 |
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