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CXCR3 Gene

protein-coding GIFtS: 66

GC0XM070752

chemokine (C-X-C motif) receptor 3
(Previous name: G protein-coupled receptor 9 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GPR9)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD182 ^², ⁵
CD183 ^¹, ²
CKR-L2 ^¹, ², ³
CMKAR3 ^¹, ²
CXC-R3 ^³
CXCR-3 ^³
GPR9 ^², ³, ⁵
IP10-R ^¹, ²
Mig-R ^²
MigR ^¹, ²
OTTHUMP00000070257 ^²

Descriptions
CD183 antigen ^³
G protein-coupled receptor 9 ^¹, ², ³
IP-10 receptor ^³
IP10 receptor ^²
Interferon-inducible protein 10 receptor ^³
Mig receptor ^²
chemokine (C-X-C motif) receptor 3 ^²
chemokine (C-X-C) receptor 3 ^²

External Ids
HGNC: 4540¹
Entrez Gene: 2833²
UniProtKB: P49682³
Ensembl: ENSG00000186810⁷

Search outside databases for aliases for CXCR3 gene

Previous GC identifers: GC0XM067009 GC0XM068313 GC0XM069068 GC0XM069702 GC0XM070618

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CXCR3:

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10

(interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC

(interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural

subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four

highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses

that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and

chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G

protein of the Gi-subclass couple to this protein. Signal transduction has not been further

analyzed but may include the same enzymes that were identified in the signaling cascade induced by

other chemokine receptors. As a consequence of chemokine-induced cellular desensitization

(phosphorylation-dependent receptor internalization), cellular responses are typically rapid and

short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular

receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in

vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues.

In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion,

suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells.

Therefore, this protein is a target for the development of small molecular weight antagonists,

which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants

encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682

Function: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial

cells (HMC). Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of

CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Isoform 2

may play a role in angiogenesis. Isoform 3 mediates activity of CXCL11

Gene Wiki entry for CXCR3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CXCR3 gene

Entrez Gene cytogenetic band: Xq13 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13

CXCR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM070752: (about GC identifiers)

Start:	70,752,491 bp from pter
End:	70,755,092 bp from pter
Size:	2,602 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011669.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682 (See protein sequence)

Recommended Name: C-X-C chemokine receptor type 3

Size: 368 amino acids; 40660 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: O15185 Q7Z710 Q9P2T4 Q9P2T5

Alternative splicing: 3 isoforms: P49682-1 P49682-2 P49682-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001136269.1 NP_001495.1

ENSEMBL proteins:

ENSP00000362791 ENSP00000362797 ENSP00000362795

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CXCR3 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CXCR3)
	Human Recombinant Proteins from Abnova (CXCR3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	10903743
GO:0005886	plasma membrane	TAS	10741397
GO:0005887	integral to plasma membrane	TAS	9064356

About this table

Antibodies for CXCR3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CXCR3
	Sigma-Aldrich Antibodies for CXCR3
	R&D Systems Antibodies for CXCR3
	Antibodies from Abcam (CXCR3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CXCR3)
	Novus Biologicals Antibodies for CXCR3

Assays for CXCR3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P49682

ProtoNet protein and cluster: P49682

2 Blocks protein families:

IPB000355 Chemokine receptor signature

IPB004070 C-X-C chemokine receptor type 3 signature

UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCR3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CXCR3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001142797

Applied Biosystems Silencer® siRNAs for CXCR3

Sigma-Aldrich siRNA and siRNA Panels for CXCR3

Sigma-Aldrich shRNA Panels and shRNA for CXCR3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CXCR3
		Millipore Clones for the Expression of CXCR3

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142797
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142797
untagged cDNA clones in CMV expression vector (see all 2): NM_001142797

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001142797

UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682

Function: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial

cells (HMC). Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of

CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Isoform 2

may play a role in angiogenesis. Isoform 3 mediates activity of CXCL11

Genatlas biochemistry entry for CXCR3:

chemokine receptor 3 for the interferon gamma inducible proteins INP10,MIG mediating a rapid

induction of effector in T lymphocytes,G protein coupled receptor superfamily

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cxcr3):

	homeostasis/metabolism	immune system	other	respiratory system
tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0016493	C-C chemokine receptor activity	IEA	--
GO:0016494	C-X-C chemokine receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CXCR3

5/78 Interacting proteins for CXCR3 (ENSP00000362795³) via UniProtKB, MINT, and/or STRING (see all 78 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CXCL10	ENSP00000305651³	STRING (score=.999)
CXCL11	ENSP00000306884³	STRING (score=.999)
CXCL9	ENSP00000354901³	STRING (score=.999)
PF4	ENSP00000296029³	STRING (score=.996)
IFNG	ENSP00000229135³	STRING (score=.993)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cell motion	TAS	10741397
GO:0006935	chemotaxis	TAS	10903763
GO:0007155	cell adhesion	TAS	10942362
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for CXCR3 available from Tocris Bioscience
10/31 Novoseek chemical compound relationships for CXCR3 gene (see all 31 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tarc	90.82	50	18276722 (4), 11920617 (3), 12911508 (2), 15944327 (2) (see all 33)
rantes	89.07	149	9856808 (3), 7531729 (3), 16239601 (3), 15126779 (3) (see all 99)
ccl3	79.66	7	15848520 (1), 17640964 (1), 12960247 (1), 15591886 (1) (see all 6)
mcp 1	57.63	2	11683586 (1), 17993576 (1)
groalpha	55.10	3	15044249 (2), 11422029 (1)
ccl4	53.60	8	19265171 (1), 15848520 (1), 12960247 (1), 15591886 (1) (see all 6)
larc	42.78	2	10934220 (1)
dimethyl fumarate	42.53	3	15663561 (1), 11422029 (1)
ifn-alpha	25.38	2	15880822 (1), 16571725 (1)
il 10	15.38	2	16219708 (1), 15833361 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCR3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CXCR3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001142797

Sigma-Aldrich siRNA and siRNA Panels for CXCR3

Sigma-Aldrich shRNA Panels and shRNA for CXCR3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001142797 NM_001504

REFSEQ mRNAs for CXCR3 gene (2 alternative transcripts):

NM_001142797.1 NM_001504.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001142797 NM_001504

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142797
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142797
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001142797

Additional cDNA sequence:

AF469635.1 AK313679.1 AY242128.1 BC034403.1 X95876.1

3 DOTS entries:

DT.75149539 DT.100746773 DT.100746772

15 AceView cDNA sequences:

BC034403 X95876 AJ346279 AJ573366 NM_001504 AF469635 BP340425 BI768435

AY242128 BQ053710 BI911171 BI821147 BQ052726 CD246172 AI587350

highest scoring ESTs for CXCR3:

X95876 AF469635 AY242128 BC034403 BI768435 BI821147 BI911171 AJ346279 AJ573366 BP340425

Unigene Cluster for CXCR3:

Chemokine (C-X-C motif) receptor 3

Hs.198252 [show with all ESTs]

Unigene Representative Sequence: NM_001142797

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000373687 ENST00000373693 ENST00000373691

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CXCR3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CXCR3

¹ / ² / ³

5 probe-sets matching CXCR3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34077_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X95876	1.00	1.00	1.00	1
207681_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001504	0.60	1.00	0.82	1
217119_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
207681_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217119_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CXCR3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTCCCCAAGA

SOURCE GeneReport for Unigene cluster: Hs.198252
Expression variation in blood from EXPOLDB for CXCR3
UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682
Tissue specificity: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and
skeletal muscle. Isoform 1 is also expressed in placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CXCR3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CXCR3¹	--	chemokine (C-X-C motif) receptor 3	85.37(n) 86.94(a)	491952 NM_001011887.1 NP_001011887.1
chimpanzee (Pan troglodytes)	CXCR3¹	--	chemokine (C-X-C motif) receptor 3	99.73(n) 100(a)	465704 XM_521125.2 XP_521125.2
cow (Bos taurus)	CXCR3¹	--	chemokine (C-X-C motif) receptor 3	87.43(n) 87.43(a)	497018 NM_001011673.1 NP_001011673.1
rat (Rattus norvegicus)	Cxcr3¹	--	chemokine (C-X-C motif) receptor 3	83.83(n) 86.65(a)	84475 NM_053415.1 NP_445867.1
mouse (Mus musculus)	Cxcr3^{1, 5}	X (41.00 cM)⁵	chemokine (C-X-C motif) receptor 3^{1, 5}	83.11(n)¹ 86.65(a)¹	12766¹ NM_009910.2¹ NP_034040.1¹ AB003174⁵ AF045146⁵ (see all 7)

About this table Species with no ortholog for CXCR3

ENSEMBL Gene Tree for CXCR3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CXCR3 gene

CXCR5² IL8RA² IL8RB² CXCR4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

9 NCBI SNPs in CXCR3 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2230438^1,2	H	70753336(-)	`GCCCAC/TATCCT`	1	H/H	syn¹ ese³		5		MN EU EA WA	468
	rs2280964^1,2	C,F,H	70754779(+)	`CCCCCC/TCCATT`	1	--	int¹		8		EU EA WA	624
	rs3091306^1,2	H	70754838(-)	`TTGGCC/AACTGA`	1	--	int¹		2		NA EU	160
--	rs3761523^1,2	--	70755610(-)	`cttttA/Tttatt`	1	--	ng3¹		0	--	--	--	--
--	rs60361088^1,2	--	70756380(+)	`ATGGGA/GTTGGG`	1	--	ng3¹		0	--	--	--	--
--	rs5981122^1,2	--	70756875(+)	`GGCCAC/GAGGGA`	1	--	ng3¹		0	--	--	--	--
--	rs56313919^1,2	--	70755954(+)	`TGTGAC/TGTGCG`	1	--	ng3¹		0	--	--	--	--
	rs34405860^1,2	--	70754306(-)	`GGGCAC/GTGGAG`	1	--	int¹		0	--	--	--	--
--	rs34334103^1,2	--	70754800(-)	`GCTTCA/GGTGTC`	1	--	int¹		0	--	--	--	--

About this table
The following additional 12 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs6625809	rs3091305	rs12007984	rs12837099	rs3091304	rs2280963	rs2280962
rs6625806	rs28426370	rs3810673	rs5936632	rs3810672

HapMap Linkage Disequilibrium images for CXCR3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300574

10/95 Novoseek disease relationships for CXCR3 gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	63.27	40	11786428 (2), 15108349 (2), 15155273 (2), 12953097 (2) (see all 29)
multiple sclerosis	57.52	17	11867072 (2), 16709257 (1), 19225413 (1), 16899302 (1) (see all 15)
lupus erythematosus cutaneous	51.07	1	18280341 (1)
mycosis fungoides	48.65	5	14708605 (2), 16713487 (1), 16931956 (1), 11242798 (1)
fibrosis idiopathic pulmonary	45.87	3	16085216 (2), 17137778 (1)
renal clear cell carcinoma	44.43	1	17997430 (1)
sarcoidosis pulmonary	43.64	6	17052298 (2), 11390417 (1), 9834133 (1), 17550373 (1)
bronchoalveolar lavage fluid	43.07	6	16085216 (1), 18644457 (1), 16490936 (1), 15956791 (1) (see all 6)
periapical granuloma	42.91	1	11683586 (1)
dermatitis atopic	41.19	8	11511293 (2), 17666357 (2), 12190665 (1), 11174204 (1) (see all 5)

About this table

Genetic Association Database: CXCR3
Human Genome Epidemiology Navigator: CXCR3 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/750 PubMed articles for CXCR3 gene (see all 750 ):

Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PubMed id 11196695)^{1, 3, 4, 6} Kato H.... Tokunaga K. (2000)
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PubMed id 9064356)^{2, 3, 4} Loetscher M....Moser B. (1996)
Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PubMed id 8666380)^{2, 3, 4} Marchese A.... Docherty J.M. (1995)
CXCR3 polymorphisms associated with risk of asthma. (PubMed id 16043121)^{1, 3, 6} Cheong H.S....Oh B. (2005)
An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. (PubMed id 12782716)^{1, 3, 4} Lasagni L.... Romagnani P. (2003)
Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (PubMed id 9625760)^{1, 3, 4} Cole K.E....Neote K. (1998)
Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping. (PubMed id 15528361)^{3, 4} Ehlert J.E.... Strieter R.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis. (PubMed id 14742268)^{1, 3} Segerer S....Grone H.J. (2004)
CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. (PubMed id 16847335)^{1, 3} Colvin R.A....Luster A.D. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2833	HGNC: 4540	AceView: CXCR3	Ensembl:ENSG00000186810	euGenes: HUgn2833
ECgene: CXCR3	H-InvDB: CXCR3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CXCR3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CXCR3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CXCR3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CXCR3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CXCR3		Antibodies for CXCR3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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Antibodies for CXCR3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CXCR3 Gene at Home site.
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CXCR3 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CXCR3

Summaries
for CXCR3

Genomic Location
for CXCR3

Proteins
for CXCR3

Protein Domains/
Families
for CXCR3

Gene Function
for CXCR3

Pathways & Interactions
for CXCR3

Drugs & Compounds
for CXCR3

Transcripts
for CXCR3

Expression
for CXCR3

Orthologs
for CXCR3

Paralogs
for CXCR3

SNPs/Variants
for CXCR3

Disorders & Mutations
for CXCR3

Medical News
for CXCR3

Publications
for CXCR3

Search for CXCR3

Genome Databases showing CXCR3

Other Databases showing CXCR3

Specialized Databases showing CXCR3

Licensable Technologies
for CXCR3

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for CXCR3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CXCR3 (Gene Symbol)
CD182
CD183
CKR-L2
CMKAR3
CXC-R3
CXCR-3
GPR9
IP10-R
Mig-R
MigR
OTTHUMP00000070257
CD183 antigen
G protein-coupled receptor 9
IP-10 receptor
IP10 receptor
Interferon-inducible protein 10 receptor
Mig receptor
chemokine (C-X-C motif) receptor 3
chemokine (C-X-C) receptor 3

CXCR3 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CXCR3

Summariesfor CXCR3

Genomic Locationfor CXCR3

Proteinsfor CXCR3

Protein Domains/Familiesfor CXCR3

Gene Functionfor CXCR3

Pathways & Interactionsfor CXCR3

Drugs & Compoundsfor CXCR3

Transcriptsfor CXCR3

Expression for CXCR3

Orthologsfor CXCR3

Paralogsfor CXCR3

SNPs/Variantsfor CXCR3

Disorders & Mutationsfor CXCR3

Medical Newsfor CXCR3

Publicationsfor CXCR3

Search for CXCR3

Genome Databases showing CXCR3

Other Databases showing CXCR3

Specialized Databases showing CXCR3

Licensable Technologiesfor CXCR3

Servicesfor CXCR3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CXCR3

Summaries
for CXCR3

Genomic Location
for CXCR3

Proteins
for CXCR3

Protein Domains/
Families
for CXCR3

Gene Function
for CXCR3

Pathways & Interactions
for CXCR3

Drugs & Compounds
for CXCR3

Transcripts
for CXCR3

Expression
for CXCR3

Orthologs
for CXCR3

Paralogs
for CXCR3

SNPs/Variants
for CXCR3

Disorders & Mutations
for CXCR3

Medical News
for CXCR3

Publications
for CXCR3

Licensable Technologies
for CXCR3

Services
for CXCR3