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CXCR3 Gene

protein-coding   GIFtS: 65
GCID: GC0XM070835

Chemokine (C-X-C Motif) Receptor 3

(Previous name: G protein-coupled receptor 9)
(Previous symbol: GPR9)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Receptor 31 2     CMKAR32
GPR91 2 3 5     IP10-R2
G Protein-Coupled Receptor 91 2 3     Mig-R2
Interferon-Inducible Protein 10 Receptor2 3     MigR2
CKR-L22 3     C-X-C Chemokine Receptor Type 32
CXC-R32 3     Chemokine (C-X-C) Receptor 32
CXCR-32 3     IP10 Receptor2
IP-10 Receptor2 3     Mig Receptor2
CD1822 5     CD183 Antigen3
CD1832     

External Ids:    HGNC: 45401   Entrez Gene: 28332   Ensembl: ENSG000001868107   OMIM: 3005745   UniProtKB: P496823   

Export aliases for CXCR3 gene to outside databases

Previous GC identifers: GC0XM067009 GC0XM068313 GC0XM069068 GC0XM069702 GC0XM070618 GC0XM070752 GC0XM064650


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCR3 Gene:
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine
induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC
(interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses
that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic
migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). (provided by
RefSeq, Jun 2011)

GeneCards Summary for CXCR3 Gene:
CXCR3 (chemokine (C-X-C motif) receptor 3) is a protein-coding gene. Diseases associated with CXCR3 include complex regional pain syndrome type 1, and alk-negative anaplastic large cell lymphoma. GO annotations related to this gene include chemokine binding and chemokine receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682
Function: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation,
survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling
pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response
Function: Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9,
CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells
(HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons.
Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of
angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1
and promotes apoptosis
Function: Isoform 3: Mediates the activity of CXCL11

Gene Wiki entry for CXCR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCR3 gene promoter:
         E2F-3a   E2F-4   E2F-5   Lmo2   E2F-2   E2F-1   E2F   PPAR-gamma2   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCR3 promoter sequence
   Search Chromatin IP Primers for CXCR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13

CXCR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCR3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM070835:  view genomic region     (about GC identifiers)

Start:
70,835,766 bp from pter      End:
70,838,367 bp from pter
Size:
2,602 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682 (See protein sequence)
Recommended Name: C-X-C chemokine receptor type 3  
Size: 368 amino acids; 40660 Da
Subunit: Homomer. Forms heteromers with ACKR4
Secondary accessions: B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5
Alternative splicing: 3 isoforms:  P49682-1   P49682-2   P49682-3   (Due to exon skipping)

Explore the universe of human proteins at neXtProt for CXCR3: NX_P49682

Explore proteomics data for CXCR3 at MOPED

Post-translational modifications: 

  • Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction1
  • N-glycosylated1
  • Glycosylation2 at Asn22, Asn32

  • See CXCR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136269.1  NP_001495.1  

    ENSEMBL proteins: 
     ENSP00000362795   ENSP00000362797  
    Reactome Protein details: P49682

    CXCR3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CXCR3 Protein
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    OriGene Protein Over-expression Lysate for CXCR3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CXCR3
    GenScript Custom Purified and Recombinant Proteins Services for CXCR3
    Novus Biologicals CXCR3 Proteins
    Novus Biologicals CXCR3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CXCR3

    CXCR3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CXCR3
    R&D Systems Antibodies for CXCR3
    OriGene Antibodies for CXCR3
    OriGene Custom Antibody Services for CXCR3
    Novus Biologicals CXCR3 Antibodies
    Abcam antibodies for CXCR3
    Cloud-Clone Corp. Antibodies for CXCR3
    ThermoFisher Antibody for CXCR3
    LSBio Antibodies in human, mouse, rat for CXCR3

    CXCR3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CXCR3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CXCR3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CXCR3
    Cloud-Clone Corp. CLIAs for CXCR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CXCR: GPCR / Class A : Chemokine receptors : C-X-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CXCR3
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004070 Chemokine_CXCR3
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P49682

    ProtoNet protein and cluster: P49682

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB004070 C-X-C chemokine receptor type 3 signature


    UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CXCR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCR3_HUMAN, P49682
    Function: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation,
    survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling
    pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response
    Function: Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9,
    CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells
    (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons.
    Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of
    angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1
    and promotes apoptosis
    Function: Isoform 3: Mediates the activity of CXCL11

         Genatlas biochemistry entry for CXCR3:
    chemokine receptor 3 for the interferon gamma inducible proteins INP10,MIG mediating a rapid induction of effector
    in T lymphocytes,G protein coupled receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA12782716
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS9064356
    GO:0016494C-X-C chemokine receptor activity IEA--
    GO:0019956chemokine binding IPI11554781
         
    CXCR3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CXCR3:
     Increased cell number in G1, a  Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cxcr3):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  normal  renal/urinary system  respiratory system  tumorigenesis 

    CXCR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CXCR3: Cxcr3tm1Wwh Cxcr3tm1Raks

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCR3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCR3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCR3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CXCR3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CXCR3:
    hsa-miR-4271 hsa-miR-1321 hsa-miR-185* hsa-miR-3154 hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidCXCR3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CXCR3
    Predesigned siRNA for gene silencing in human, mouse, rat CXCR3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CXCR3

    Clone
    Products:
         
    OriGene clones in human, mouse for CXCR3 (see all 12)
    OriGene ORF clones in mouse, rat for CXCR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CXCR3 (NM_001504)
    Sino Biological Human cDNA Clone for CXCR3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CXCR3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CXCR3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXCR3_HUMAN, P49682: Isoform 1: Cell membrane; Multi-pass membrane protein
    CXCR3_HUMAN, P49682: Isoform 2: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10903743
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9064356
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane ----

    CXCR3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXCR3 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    5Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CXCR3
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCR3 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    4 BioSystems Pathways for CXCR3
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    CXCR3-mediated signaling events
    Peptide GPCRs


    2 Reactome Pathways for CXCR3
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    2 Kegg Pathways  (Kegg details for CXCR3):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CXCR3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCR3 (see all 9): 
              Multiple Sclerosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CXCR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CXCR3 (P496823 ENSP000003627954) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCL11O146253, ENSP000003068844I2D: score=3 STRING: ENSP00000306884
    CXCL13O439273, ENSP000002867584I2D: score=3 STRING: ENSP00000286758
    CXCL9Q073253, ENSP000003549014I2D: score=3 STRING: ENSP00000354901
    PF4P027763, ENSP000002960294I2D: score=3 STRING: ENSP00000296029
    CCL11P516713, ENSP000003022344I2D: score=1 STRING: ENSP00000302234
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001937negative regulation of endothelial cell proliferation IDA12782716
    GO:0002685regulation of leukocyte migration IEA--
    GO:0006915apoptotic process IEA--
    GO:0006928cellular component movement TAS10741397

    CXCR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXCR3

    Selected IUPHAR Ligands for CXCR3 (CXCR3) (see all 17)    About this table
    LigandTypeActionAffinityPubmed IDs
    CXCL11
    AgonistFull agonist10.4 - 10.515761110
    CXCL10
    AgonistFull agonist7.8 - 9.89660793 15761110
    NBI-74330
    AntagonistAntagonist8.3 - 8.815761110
    CXCL9
    AgonistFull agonist7.3 - 8.39660793 15761110
    CCL13
    AgonistFull agonist7.29660793
    duramycin
    AntagonistAntagonist715789559
    CCL20
    AgonistFull agonist6.89660793
    CCL5
    AgonistFull agonist6.49660793
    SDF-1alpha
    AgonistFull agonist6.49660793
    dioscin
    AntagonistAntagonist6.315789559

    Selected Novoseek inferred chemical compound relationships for CXCR3 gene (see all 47)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 90.5 53 18276722 (4), 11920617 (3), 12911508 (2), 15944327 (2) (see all 35)
    rantes 89.4 168 9856808 (3), 7531729 (3), 16239601 (3), 15126779 (3) (see all 99)
    ccl3 79.3 11 20205697 (2), 19906920 (1), 15848520 (1), 17640964 (1) (see all 9)
    mcp 1 65.7 5 20205697 (2), 11683586 (1), 20332253 (1), 17993576 (1)
    groalpha 62.6 4 15044249 (2), 19819721 (1), 11422029 (1)
    ccl4 54.9 9 19265171 (1), 15848520 (1), 12960247 (1), 15591886 (1) (see all 7)
    larc 39.4 2 10934220 (1)
    dimethyl fumarate 38.7 3 15663561 (1), 11422029 (1)
    vegf 38 28 16484616 (5), 20137269 (3), 12788875 (2), 16518330 (2) (see all 17)
    ifn-alpha 22.5 2 15880822 (1), 16571725 (1)



    CXCR3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CXCR3 gene (2 alternative transcripts): 
    NM_001142797.1  NM_001504.1  

    Unigene Cluster for CXCR3:

    Chemokine (C-X-C motif) receptor 3
    Hs.198252  [show with all ESTs]
    Unigene Representative Sequence: NM_001142797
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373691(uc011mpx.2) ENST00000373693(uc004eaf.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate CXCR3:
    hsa-miR-4271 hsa-miR-1321 hsa-miR-185* hsa-miR-3154 hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidCXCR3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CXCR3
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CXCR3 (NM_001504)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR3
    Primer
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    OriGene qPCR primer pairs and template standards for CXCR3
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCR3
      QuantiTect SYBR Green Assays in human, mouse, rat CXCR3
      QuantiFast Probe-based Assays in human, mouse, rat CXCR3

    Additional mRNA sequence: 

    AF469635.1 AK313679.1 AY242128.1 BC034403.1 X95876.1 

    3 DOTS entries:

    DT.75149539  DT.100746773  DT.100746772 

    15 AceView cDNA sequences:

    BQ053710 AY242128 BC034403 BI768435 AF469635 NM_001504 X95876 AJ573366 
    BP340425 AJ346279 BI821147 BI911171 BQ052726 CD246172 AI587350 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXCR3 expression in normal human tissues (normalized intensities)      CXCR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCCCAAGA
    CXCR3 Expression
    About this image


    CXCR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
     
     Pancreas (Endocrine System)
    CXCR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXCR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.198252

    UniProtKB/Swiss-Prot: CXCR3_HUMAN, P49682
    Tissue specificity: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle.
    Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at
    protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCR3 (see all 9): 
              Multiple Sclerosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXCR3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcr31 , 5 chemokine (C-X-C motif) receptor 31, 5 83.06(n)1
    86.54(a)1
      X (44.58 cM)5
    127661  NM_009910.21  NP_034040.11 
     1017315355 
    lizard
    (Anolis carolinensis)
    Reptilia CXCR36
    chemokine (C-X-C motif) receptor 3
    46(a)
    1 ↔ 1
    GL343868.1(20789-28934)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004856361 c-X-C chemokine receptor type 3-like 53.56(n)
    49.09(a)
      100485636  XM_002938533.2  XP_002938579.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cxcr3.11 chemokine (C-X-C motif) receptor 3, tandem duplicate more 55.38(n)
    45.45(a)
      654692  NM_001089430.2  NP_001082899.2 


    ENSEMBL Gene Tree for CXCR3 (if available)
    TreeFam Gene Tree for CXCR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CXCR3 gene
    CCR52  CCR62  CXCR62  ACKR42  XCR12  CCR92  CCRL22  CCR72  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CXCR3 using alignment to 1 protein entry:     CXCR3_HUMAN(see all similar genes):
    CCR7    CCR5    ACKR2    CCBP2    CXCR4    CCR2
    BLR1    CCR1    CCR3    CCR4    CXCR1    CXCR2
    CXCR5    IL8RB    ACKR4    CCR6    CCRL1    CXCR6

    CXCR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXCR3 (see all 75)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882263381,2
    --70841835(+) CCTTAG/TGCCTG 2 -- ds50010--------
    rs1490884841,2
    --70841880(+) CTTCCC/TAAATG 2 -- ds50010--------
    rs1925662731,2
    --70841961(+) GGTTTC/TGCTAG 2 -- ds50010--------
    rs1847875431,2
    --70842226(+) TGGAGC/GCCAGG 2 -- ds50010--------
    rs1900353761,2
    --70842261(+) CACGAA/CCATGC 2 -- ds50010--------
    rs1812459001,2
    --70842444(+) CACTTA/GGGGAA 2 -- ut310--------
    rs1997144781,2
    C--70842835(+) AGCATA/CCACAT 4 W C mis10--------
    rs2003525031,2
    --70842848(+) GCTCCC/TGGAAC 4 Q R mis10--------
    rs1474344661,2
    C,F--70842853(+) CGGAAC/GTTGAC 4 N K mis11Minor allele frequency- G:0.00NA 4514
    rs1392268231,2,,4
    C--70842950(+) TTTCTC/TGGCCA 4 Q R mis11Minor allele frequency- T:0.00NA 4542

    HapMap Linkage Disequilibrium report for CXCR3 (70835766 - 70838367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CXCR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6954CNV Insertion18451855
    esv33082CNV Loss17666407
    esv1584074OTHER Inversion17803354

    Human Gene Mutation Database (HGMD): CXCR3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCR3
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300574    OMIM disorders: --

    Selected diseases for CXCR3 (see all 177):    About MalaCards
    complex regional pain syndrome type 1    alk-negative anaplastic large cell lymphoma    lichen planus    mycosis fungoides
    peripheral t-cell lymphoma    viral meningitis    intermediate uveitis    chromoblastomycosis
    complex regional pain syndrome    periapical granuloma    pulmonary sarcoidosis    paragonimiasis
    nonspecific interstitial pneumonia    proliferative glomerulonephritis    secondary progressive multiple sclerosis    chronic eosinophilic pneumonia
    aphthous stomatitis    central nervous system disease    bronchiolitis obliterans    uveitis

    4 diseases from the University of Copenhagen DISEASES database for CXCR3:
    Multiple sclerosis     Hypersensitivity reaction type II disease     Dermatitis     Rheumatoid arthritis

    CXCR3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CXCR3 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 63.6 46 11786428 (2), 15108349 (2), 15155273 (2), 12953097 (2) (see all 32)
    multiple sclerosis 56 18 11867072 (2), 16709257 (1), 19225413 (1), 16899302 (1) (see all 16)
    fibrosis idiopathic pulmonary 54.7 5 20137269 (2), 16085216 (2), 17137778 (1)
    sarcoidosis pulmonary 52.4 7 17052298 (2), 19386686 (1), 11390417 (1), 9834133 (1) (see all 5)
    mycosis fungoides 48.8 5 14708605 (2), 16713487 (1), 16931956 (1), 11242798 (1)
    lupus erythematosus cutaneous 48.6 1 18280341 (1)
    bronchoalveolar lavage fluid 48.2 8 19842835 (1), 19878731 (1), 16085216 (1), 18644457 (1) (see all 8)
    necrosis 43.9 35 9354680 (4), 8943014 (3), 19095263 (2), 16299288 (1) (see all 27)
    lymphomatoid papulosis 42.5 2 16931956 (1), 11242798 (1)
    lymphoma t-cell 42 7 15328188 (1), 16931956 (1), 19887486 (1), 10887135 (1) (see all 7)

    Genetic Association Database (GAD): CXCR3
    Human Genome Epidemiology (HuGE) Navigator: CXCR3 (9 documents)

    Export disorders for CXCR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXCR3 gene, integrated from 10 sources (see all 891):
    (articles sorted by number of sources associating them with CXCR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PubMed id 11196695)1, 2, 4, 9 Kato H.... Tokunaga K. (Genes Immun. 2000)
    2. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PubMed id 9064356)1, 2, 3 Loetscher M.... Moser B. (J. Exp. Med. 1996)
    3. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PubMed id 8666380)1, 2, 3 Marchese A.... Docherty J.M. (Genomics 1995)
    4. CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. (PubMed id 16847335)1, 2, 9 Colvin R.A.... Luster A.D. (Mol. Cell. Biol. 2006)
    5. CXCR3 polymorphisms associated with risk of asthma. (PubMed id 16043121)1, 4, 9 Cheong H.S....Oh B. (Biochem. Biophys. Res. Commun. 2005)
    6. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. (PubMed id 12782716)1, 2, 9 Lasagni L.... Romagnani P. (J. Exp. Med. 2003)
    7. Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B. (PubMed id 18291705)1, 2, 9 Petrai I.... Marra F. (Int. J. Biochem. Cell Biol. 2008)
    8. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (PubMed id 9625760)1, 2, 9 Cole K.E....Neote K. (J. Exp. Med. 1998)
    9. Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR. (PubMed id 23121557)1, 2 Vinet J....Boddeke H.W. (Br. J. Pharmacol. 2013)
    10. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2833 HGNC: 4540 AceView: CXCR3 Ensembl:ENSG00000186810 euGenes: HUgn2833
    ECgene: CXCR3 Kegg: 2833 H-InvDB: CXCR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXCR3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCR3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXCR3 gene:
    Search GeneIP for patents involving CXCR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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