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CXCR2 Gene

protein-coding   GIFtS: 65
GCID: GC02P219021

Chemokine (C-X-C Motif) Receptor 2

(Previous names: interleukin 8 receptor, beta)
(Previous symbol: IL8RB)
  See CXCR2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Receptor 21 2     CD1822
IL8RB1 2 3 5     CMKAR22
Interleukin 8 Receptor, Beta1 2     IL8RA2
High Affinity Interleukin-8 Receptor B2 3     C-X-C Chemokine Receptor Type 22
CDw128b2 3     Chemokine (CXC) Receptor 22
CXC-R22 3     CXCR2 Gene For IL8 Receptor Type B2
CXCR-22 3     Interleukin 8 Receptor B2
GRO/MGSA Receptor2 3     Interleukin 8 Receptor Type 22
IL-8 Receptor Type 22 3     Interleukin-8 Receptor Type B2
IL-8R B2 3     CD182 Antigen3
IL8R22 5     

External Ids:    HGNC: 60271   Entrez Gene: 35792   Ensembl: ENSG000001808717   OMIM: 1469285   UniProtKB: P250253   

Export aliases for CXCR2 gene to outside databases

Previous GC identifers: GC02P218699 GC02P218991 GC02P210842 GC02P218994 GC02P219006 GC02P219012


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCR2 Gene:
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor
for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein
activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a
protein with melanoma growth stimulating activity, and has been shown to be a major component required for
serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The
angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this
receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte
precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high
affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to
chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. (provided
by RefSeq, Nov 2009)

GeneCards Summary for CXCR2 Gene:
CXCR2 (chemokine (C-X-C motif) receptor 2) is a protein-coding gene. Diseases associated with CXCR2 include human granulocytic anaplasmosis, and classic kaposi sarcoma. GO annotations related to this gene include interleukin-8 binding and signal transducer activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CXCR2_HUMAN, P25025
Function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the
receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a
phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high
affinity to CXCL3, GRO/MGSA and NAP-2

summary for CXCR2 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CXCR2 (Interleukin 8 receptor, beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CXCR2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCR2 promoter sequence
   Search Chromatin IP Primers for CXCR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CXCR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCR2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219021:  view genomic region     (about GC identifiers)

Start:
218,990,012 bp from pter      End:
219,001,976 bp from pter
Size:
11,965 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CXCR2_HUMAN, P25025 (See protein sequence)
Recommended Name: C-X-C chemokine receptor type 2  
Size: 360 amino acids; 40759 Da
Secondary accessions: Q8IUZ1 Q9P2T6 Q9P2T7

Explore the universe of human proteins at neXtProt for CXCR2: NX_P25025

Explore proteomics data for CXCR2 at MOPED

Post-translational modifications: 

  • Phosphorylated upon ligand binding; which is required for desensitization1
  • Glycosylation2 at Asn22
  • Modification sites at PhosphoSitePlus

  • See CXCR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161770.1  NP_001548.1  

    ENSEMBL proteins: 
     ENSP00000413686   ENSP00000392348   ENSP00000410506   ENSP00000319635   ENSP00000415148  
     ENSP00000392698   ENSP00000416815  
    Reactome Protein details: P25025

    CXCR2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CXCR2 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CXCR2
    OriGene Protein Over-expression Lysate for CXCR2
    OriGene MassSpec for CXCR2
    OriGene Custom Protein Services for CXCR2
    GenScript Custom Purified and Recombinant Proteins Services for CXCR2
    Novus Biologicals CXCR2 Protein
    Novus Biologicals CXCR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CXCR2 

     
    antibodies-online proteins for CXCR2 (4 products) 

     
    antibodies-online peptides for CXCR2

    CXCR2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CXCR2
    R&D Systems Antibodies for CXCR2 (CXCR2/IL-8 RB)
    OriGene Antibodies for CXCR2
    OriGene Custom Antibody Services for CXCR2
    Novus Biologicals CXCR2 Antibodies
    Abcam antibodies for CXCR2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CXCR2
    antibodies-online antibodies for CXCR2 (64 products) 

    CXCR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CXCR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CXCR2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CXCR2 
    antibodies-online kits for CXCR2 (29 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors
    CXCR: GPCR / Class A : Chemokine receptors : C-X-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CXCR2
    Chemokine receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000174 Chemokine_CXCR_1/2
     IPR000057 Chemokine_CXCR2
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P25025

    ProtoNet protein and cluster: P25025

    2 Blocks protein domains:
    IPB000057 Interleukin 8B receptor signature
    IPB000174 Interleukin-8 receptor signature


    UniProtKB/Swiss-Prot: CXCR2_HUMAN, P25025
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CXCR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCR2_HUMAN, P25025
    Function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the
    receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a
    phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high
    affinity to CXCL3, GRO/MGSA and NAP-2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IDA10438939
    GO:0004918interleukin-8 receptor activity IDA10820279
    GO:0004930G-protein coupled receptor activity ----
    GO:0005515protein binding IPI--
    GO:0016494C-X-C chemokine receptor activity IDA10878382
         
    Find genes that share ontologies with CXCR2           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cxcr2) (see all 16):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  nervous system 
     renal/urinary system  reproductive system  respiratory system  skeleton  tumorigenesis 

    Find genes that share phenotypes with CXCR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cxcr2tm1Mwm for CXCR2

       genOway: Develop your customized and physiologically relevant rodent model for CXCR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CXCR2:
    hsa-mir-335-5p (MIRT017358)

    Block miRNA regulation of human, mouse, rat CXCR2 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CXCR2:
    hsa-miR-485-5p hsa-miR-1321 hsa-miR-185*
    SwitchGear 3'UTR luciferase reporter plasmidCXCR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CXCR2
    Predesigned siRNA for gene silencing in human, mouse, rat CXCR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CXCR2

    Clone
    Products:
         
    OriGene clones in human, mouse for CXCR2 (see all 11)
    OriGene ORF clones in mouse, rat for CXCR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CXCR2 (NM_001557)
    Sino Biological Human cDNA Clone for CXCR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CXCR2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CXCR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXCR2_HUMAN, P25025: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    plasma membrane5
    vacuole5
    extracellular2
    nucleus2
    cytoskeleton1
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA10878382
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10438939
    GO:0009986cell surface IDA10878382
    GO:0016020membrane IDA10725748

    Find genes that share ontologies with CXCR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXCR2 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51


    Find genes that share SuperPaths with CXCR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CXCR2
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCR2 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    1 GeneGo (Thomson Reuters) Pathway for CXCR2
        Inhibitory action of Lipoxins on neutrophil migration

    3 BioSystems Pathways for CXCR2
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    2 Reactome Pathways for CXCR2
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    4 Kegg Pathways  (Kegg details for CXCR2):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Endocytosis
    Epithelial cell signaling in Helicobacter pylori infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCR2 (see all 6): 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Tumor Metastasis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CXCR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CXCR2 (P250251, 2, 3 ENSP000003196354) via UniProtKB, MINT, STRING, and/or I2D (see all 204)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL8P101451, 3, ENSP000003065124EBI-2835281,EBI-3917999 I2D: score=4 STRING: ENSP00000306512
    GRIA1P422612, 3, ENSP000002859004MINT-49811 I2D: score=2 STRING: ENSP00000285900
    GNA15P306793, ENSP000002629584I2D: score=2 STRING: ENSP00000262958
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    GTF3AQ926643, ENSP000003705324I2D: score=2 STRING: ENSP00000370532
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002407dendritic cell chemotaxis TAS16621978
    GO:0002438acute inflammatory response to antigenic stimulus IEA--
    GO:0002690positive regulation of leukocyte chemotaxis ----
    GO:0006915apoptotic process ----
    GO:0006935chemotaxis IDA10725748

    Find genes that share ontologies with CXCR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CXCR2
      Browse compounds at ApexBio 

    Compounds for CXCR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

    1 HMDB Compound for CXCR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for CXCR2 (CXCR2) (see all 14)    About this table
    LigandTypeActionAffinityPubmed IDs
    CXCL1
    AgonistFull agonist8.4 - 9.71379593 10188995 8940121
    CXCL8
    AgonistFull agonist8.8 - 9.51379593 15946947 15282370 10188995 8940121
    [125I]CXCL8 (human)
    AgonistFull agonist9 - 9.410188995 12626541
    CXCL7
    AgonistFull agonist6.3 - 9.38702798
    CXCL3
    AgonistFull agonist7.8 - 9.28702798
    CXCL2
    AgonistFull agonist7 - 9.18702798
    CXCL5
    AgonistFull agonist6.9 - 98702798
    SB 225002
    AntagonistAntagonist7.79553055
    CXCL6
    AgonistFull agonist79692902
    SK&F 83589
    AntagonistAntagonist6.39553055

    Selected Novoseek inferred chemical compound relationships for CXCR2 gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    groalpha 91.1 40 9195914 (3), 10188995 (3), 11023662 (2), 8940121 (2) (see all 19)
    grogamma 81.7 9 8702798 (3), 20044480 (1), 9553055 (1)
    grobeta 79.2 15 8702798 (3), 16540656 (3), 18292390 (1), 20044480 (1) (see all 5)
    rantes 69.2 5 12606476 (1), 19201759 (1), 18226915 (1), 19024011 (1) (see all 5)
    fmlp 48.9 15 9933081 (2), 12632286 (2), 9726994 (1), 11509630 (1) (see all 6)
    calcium 44.5 38 12975484 (3), 9726994 (2), 9195914 (2), 10188995 (2) (see all 25)
    phosphoinositide 43.4 6 9726994 (1), 12975484 (1), 18205049 (1), 8910508 (1) (see all 5)
    lipoteichoic acid 39.1 5 19234125 (1), 10950785 (1)
    leukotriene b4 36.5 4 19048279 (2), 12962514 (1)
    matrigel 34.1 1 15688008 (1)



    Find genes that share compounds with CXCR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CXCR2 gene (2 alternative transcripts): 
    NM_001168298.1  NM_001557.3  

    Unigene Cluster for CXCR2:

    Chemokine (C-X-C motif) receptor 2
    Hs.846  [show with all ESTs]
    Unigene Representative Sequence: BC037961
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453237 ENST00000415392 ENST00000449014 ENST00000318507(uc002vgz.2 uc002vha.2 uc002vhb.2)
    ENST00000454148 ENST00000428565 ENST00000418878
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CXCR2:
    hsa-miR-485-5p hsa-miR-1321 hsa-miR-185*
    SwitchGear 3'UTR luciferase reporter plasmidCXCR2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CXCR2
    Predesigned siRNA for gene silencing in human, mouse, rat CXCR2
    Clone
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    OriGene clones in human, mouse for CXCR2 (see all 11)
    OriGene ORF clones in mouse, rat for CXCR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CXCR2 (NM_001557)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CXCR2
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCR2
      QuantiTect SYBR Green Assays in human, mouse, rat CXCR2
      QuantiFast Probe-based Assays in human, mouse, rat CXCR2

    Additional mRNA sequence: 

    AK290906.1 AK312664.1 BC037961.1 L19593.1 M73969.1 M94582.1 U11872.1 U11873.1 
    U11874.1 U11875.1 U11876.1 U11877.1 U11878.1 

    5 DOTS entries:

    DT.97808170  DT.95158063  DT.120988158  DT.100745565  DT.120988168 

    Selected AceView cDNA sequences (see all 25):

    U11876 BF902796 U11878 U11875 BC037961 CN832049 U11872 U11873 
    U11877 BQ705921 NM_001557 BQ028774 M73969 C01674 AU136738 U11874 
    AU156845 BI057217 L19593 M94582 BQ709237 CD695992 CD612009 BE831747 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CXCR2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for CXCR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXCR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACTCTATG
    CXCR2 Expression
    About this image

    CXCR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXCR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.846
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCR2 (see all 6): 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Tumor Metastasis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXCR2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcr21 , 5 chemokine (C-X-C motif) receptor 21, 5 77.72(n)1
    71.31(a)1
      1 (38.41 cM)5
    127651  NM_009909.31  NP_034039.11 
     741539895 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    57(a)
    56(a)
    many ↔ many
    many ↔ many
    1(88971792-88972871)
    1(88981687-88982766)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017321651 c-X-C chemokine receptor type 2-like 65.33(n)
    59(a)
      101732165  XM_004917619.1  XP_004917676.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7967241 c-X-C chemokine receptor type 1-like 55.25(n)
    45.26(a)
      796724  XM_001337057.3  XP_001337093.2 


    ENSEMBL Gene Tree for CXCR2 (if available)
    TreeFam Gene Tree for CXCR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CXCR2 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    CCR72  ACKR22  CX3CR12  CCR82  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CXCR2 using alignment to 5 protein entries:     CXCR2_HUMAN (see all proteins) (see all similar genes):
    IL8RB    CXCR1    CCR2    CCR7    C3AR1    CCR6
    CX3CR1    ACKR2    CCR4    CCR5    CCBP2    CCR8
    CCR-5    FPR2    AGTR1    CMKLR1    CCR3    CCR9

    Find genes that share paralogs with CXCR2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CXCR2
    PGOHUM00000240523


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXCR2 (see all 496)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs46728721,2
    C--218988061(+) cttggA/Gcccgg 1 -- us2k1 tfbs34Minor allele frequency- G:0.00NA CSA 7
    rs1874205551,2
    --218988063(+) TGGGCC/TCGGGA 1 -- us2k10--------
    rs1154116891,2
    F--218988133(+) GAAAAT/CCTGTC 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs710644121,2
    C--218988381(-) ATCTCA/-AAAAA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1888753861,2
    --218988416(+) CTCTTA/GTTACC 1 -- us2k10--------
    rs1172540241,2
    F--218988447(+) GATCTC/TGGCTC 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1817419481,2
    --218988497(+) TCTCAA/GCCTCC 1 -- us2k10--------
    rs1129989231,2
    C,F--218988539(+) ACACCC/TGGCTA 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1497140741,2
    --218988658(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs1456502721,2
    C--218988669(+) CACCAC/TGCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CXCR2 (218990012 - 219001976 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CXCR2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146928    OMIM disorders: --

    8 diseases for CXCR2:    
    About MalaCards
    human granulocytic anaplasmosis    classic kaposi sarcoma    hyper ige syndrome    mycetoma
    bacteriuria    behcet's disease    kaposi's sarcoma    pancreatic cancer

    2 diseases from the University of Copenhagen DISEASES database for CXCR2:
    Lung disease     Cancer

    Find genes that share disorders with CXCR2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CXCR2 gene (see all 51)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 57 18 10542945 (2), 10623425 (1), 10688807 (1), 15598788 (1) (see all 16)
    melanoma 44.1 59 19401689 (5), 19585580 (5), 16393674 (5), 14713106 (5) (see all 27)
    pulmonary disease chronic obstructive 42.6 6 12857718 (1), 15637552 (1), 19026683 (1), 15772681 (1)
    neovascularization 35.2 2 19255141 (1), 15672235 (1)
    leukemia basophilic 32.8 2 15896307 (1), 7578017 (1)
    metastasis 28.8 9 16393674 (2), 11595728 (1), 8363581 (1), 14713106 (1) (see all 7)
    tumors 26.8 54 16210641 (4), 19887480 (3), 19585580 (2), 18096634 (2) (see all 28)
    necrosis 25.8 7 10454826 (1), 10593336 (1), 10950785 (1), 9334359 (1) (see all 7)
    fibrosis idiopathic pulmonary 22.2 3 10902769 (1)
    lung diseases 15.9 2 19026683 (2)

    Genetic Association Database (GAD): CXCR2
    Human Genome Epidemiology (HuGE) Navigator: CXCR2 (58 documents)

    Export disorders for CXCR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXCR2 gene, integrated from 10 sources (see all 538):
    (articles sorted by number of sources associating them with CXCR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PubMed id 11196695)1, 2, 9 Kato H.... Tokunaga K. (Genes Immun. 2000)
    2. Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. (PubMed id 7929358)1, 2, 9 Ahuja S.K.... Murphy P.M. (J. Biol. Chem. 1994)
    3. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. (PubMed id 1427896)1, 3, 9 Morris S.W....Cerretti D.P. (Genomics 1992)
    4. Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor. (PubMed id 9079638)1, 2, 9 Mueller S.G.... Richmond A. (J. Biol. Chem. 1997)
    5. Characterization of two high affinity human interleukin-8 receptors. (PubMed id 1379593)1, 2, 9 Lee J.... Wood W.I. (J. Biol. Chem. 1992)
    6. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    7. Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. (PubMed id 20016852)1, 4 Hawn T.R....Hooton T.M. (PLoS ONE 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Structure, genomic organization, and expression of the human interleukin-8 receptor B gene. (PubMed id 7512557)1, 2 Sprenger H.... Kelvin D.J. (J. Biol. Chem. 1994)
    10. Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2. (PubMed id 8384312)1, 2 Cerretti D.P....Beckmann M.P. (Mol. Immunol. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3579 HGNC: 6027 AceView: IL8RB Ensembl:ENSG00000180871 euGenes: HUgn3579
    ECgene: CXCR2 Kegg: 3579 H-InvDB: CXCR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXCR2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXC_chemokine_receptors
    SeattleSNPshttp://pga.gs.washington.edu/data/il8rb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXCR2 gene:
    Search GeneIP for patents involving CXCR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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