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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCR2 Gene

protein-coding   GIFtS: 62
GCID: GC02P219006

chemokine (C-X-C motif) receptor 2

(Previous names: interleukin 8 receptor, beta )
(Previous symbol: IL8RB)
 Explore 98 diseases affiliated with
CXCR2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CXCR2    

Aliases
for CXCR2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-X-C Motif) Receptor 21 2     IL-8R B2 3
IL8RB1 2 3 5     IL8R22 5
CD1821 2     IL8RA2
CMKAR21 2     C-X-C Chemokine Receptor Type 22
Interleukin 8 Receptor, Beta1 2     Chemokine (CXC) Receptor 22
High Affinity Interleukin-8 Receptor B2 3     CXCR2 Gene For IL8 Receptor Type B2
CDw128b2 3     Interleukin 8 Receptor B2
CXC-R22 3     Interleukin 8 Receptor Type 22
CXCR-22 3     Interleukin-8 Receptor Type B2
GRO/MGSA Receptor2 3     CD182 Antigen3
IL-8 Receptor Type 22 3     

External Ids:    HGNC: 60271   Entrez Gene: 35792   Ensembl: ENSG000001808717   OMIM: 1469285   UniProtKB: P250253   

Export aliases for CXCR2 gene to outside databases

Previous GC identifers: GC02P218699 GC02P218991 GC02P210842 GC02P218994


Summaries
for CXCR2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CXCR2:
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for
interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated
second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with
melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma
cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in
intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice
suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by
arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a
pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants,
encoding the same protein, have been identified. (provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: CXCR2_HUMAN, P25025
Function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor
causes activation of neutrophils. This response is mediated via a G-protein that activates a
phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity
to CXCL3, GRO/MGSA and NAP-2

Gene Wiki entry for CXCR2 (Interleukin 8 receptor, beta)


Genomic Views
for CXCR2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CXCR2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CXCR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCR2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219006:  view genomic region     (about GC identifiers)

Start:
 218,990,012 bp from pter      End:
 219,001,976 bp from pter
Size:
 11,965 bases      Orientation:
 plus strand

Proteins
for CXCR2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CXCR2_HUMAN, P25025 (See protein sequence)
Recommended Name: C-X-C chemokine receptor type 2  
Size: 360 amino acids; 40759 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q8IUZ1 Q9P2T6 Q9P2T7

Explore the universe of human proteins at neXtProt for CXCR2: NX_P25025

Post-translational modifications:

  • Phosphorylated upon ligand binding; which is required for desensitization1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P25025

    • CXCR2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161770.1  NP_001548.1  

    ENSEMBL proteins: 
     ENSP00000413686   ENSP00000392348   ENSP00000410506   ENSP00000319635   ENSP00000415148  
     ENSP00000392698   ENSP00000416815  
    Reactome Protein details: P25025
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): CXCR2
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    Novus Biologicals CXCR2 Protein
    Novus Biologicals CXCR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA10878382
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10438939
    GO:0009986cell surface IDA10878382
    GO:0016020membrane IDA10725748


    CXCR2 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for CXCR2

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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CXCR2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CXCR2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000174 Chemokine_CXCR
     IPR000057 Chemokine_CXCR2
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P25025

    ProtoNet protein and cluster: P25025

    2 Blocks protein families:
    IPB000057 Interleukin 8B receptor signature
    IPB000174 Interleukin-8 receptor signature


    UniProtKB/Swiss-Prot: CXCR2_HUMAN, P25025
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for CXCR2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CXCR2_HUMAN, P25025
    Function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor
    causes activation of neutrophils. This response is mediated via a G-protein that activates a
    phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity
    to CXCL3, GRO/MGSA and NAP-2

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCR2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCR2:
    hsa-miR-485-5p hsa-miR-1321 hsa-miR-185*
    SwitchGear 3'UTR luciferase reporter plasmid: CXCR2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCR2 (see all 3)
    OriGene siRNA: CXCR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCR2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CXCR2

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CXCR2 (NM_001557)
    Sino Biological Human cDNA Clone for CXCR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CXCR2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR2

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IDA10878382
    GO:0004918interleukin-8 receptor activity IDA10820279
    GO:0005515protein binding ----
    GO:0016494C-X-C chemokine receptor activity IDA10878382
    GO:0019959interleukin-8 binding IPI1840701


    CXCR2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cxcr2tm1Mwm for CXCR2
         15/16 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cxcr2) (see all 16):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  nervous system 
     renal/urinary system  reproductive system  respiratory system  skeleton  tumorigenesis 

    CXCR2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CXCR2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    		Peptide ligand-binding receptors0.61
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    		Peptide GPCRs0.46
    4Chemokine receptors bind chemokines
    		Chemokine receptors bind chemokines1.00
    5GPCRs, Other
    		GPCRs, Other1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CXCR2
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    1 GeneGo (Thomson Reuters) Pathway for CXCR2
        Inhibitory action of Lipoxins on neutrophil migration

    3 BioSystems Pathways for CXCR2 
        GPCRs, Class A Rhodopsin-like
    GPCRs, Other
    Peptide GPCRs

    5/8        Reactome Pathways for CXCR2 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    4         Kegg Pathways  (Kegg details for CXCR2):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Endocytosis
    Epithelial cell signaling in Helicobacter pylori infection


    CXCR2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CXCR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/204 Interacting proteins for CXCR2 (P250252, 3 ENSP000003196354) via UniProtKB, MINT, STRING, and/or I2D (see all 204)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIA1P422612, 3, ENSP000002859004MINT-49811 I2D: score=2 STRING: ENSP00000285900
    IL8P101453, ENSP000003065124I2D: score=4 STRING: ENSP00000306512
    GNA15P306793, ENSP000002629584I2D: score=2 STRING: ENSP00000262958
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    GTF3AQ926643, ENSP000003705324I2D: score=2 STRING: ENSP00000370532
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002407dendritic cell chemotaxis TAS16621978
    GO:0006915apoptotic process IEA--
    GO:0006935chemotaxis IDA10725748
    GO:0006954inflammatory response TAS9725262
    GO:0006968cellular defense response IDA10725748


    CXCR2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CXCR2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCR2 for compounds           About GeneDecksing

    EMD Millipore small molecules for CXCR2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CXCR2

    Compounds for CXCR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]

    1 HMDB Compound for CXCR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/31 Novoseek chemical compound relationships for CXCR2 gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    groalpha 91.1 40 9195914 (3), 10188995 (3), 11023662 (2), 8940121 (2) (see all 19)
    grogamma 81.7 9 8702798 (3), 20044480 (1), 9553055 (1)
    grobeta 79.2 15 8702798 (3), 16540656 (3), 18292390 (1), 20044480 (1) (see all 5)
    rantes 69.2 5 12606476 (1), 19201759 (1), 18226915 (1), 19024011 (1) (see all 5)
    fmlp 48.9 15 9933081 (2), 12632286 (2), 9726994 (1), 11509630 (1) (see all 6)
    calcium 44.5 38 12975484 (3), 9726994 (2), 9195914 (2), 10188995 (2) (see all 25)
    phosphoinositide 43.4 6 9726994 (1), 12975484 (1), 18205049 (1), 8910508 (1) (see all 5)
    lipoteichoic acid 39.1 5 19234125 (1), 10950785 (1)
    leukotriene b4 36.5 4 19048279 (2), 12962514 (1)
    matrigel 34.1 1 15688008 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCR2 

    Transcripts
    for CXCR2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CXCR2 gene (2 alternative transcripts): 
    NM_001168298.1  NM_001557.3  

    Unigene Cluster for CXCR2:

    Chemokine (C-X-C motif) receptor 2
    Hs.846  [show with all ESTs]
    Unigene Representative Sequence: BC037961
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453237 ENST00000415392 ENST00000449014 ENST00000318507(uc002vgz.2 uc002vha.2 uc002vhb.2)
    ENST00000454148 ENST00000428565 ENST00000418878

    miRNA
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    hsa-miR-485-5p hsa-miR-1321 hsa-miR-185*
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCR2 (see all 3)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK290906.1 AK312664.1 BC037961.1 L19593.1 M73969.1 M94582.1 U11872.1 U11873.1 
    U11874.1 U11875.1 U11876.1 U11877.1 U11878.1 

    5 DOTS entries:

    DT.97808170  DT.95158063  DT.120988158  DT.100745565  DT.120988168 

    24/25 AceView cDNA sequences (see all 25):

    BQ705921 U11876 U11873 NM_001557 CN832049 BC037961 U11877 U11878 
    BF902796 U11875 BQ028774 U11872 BQ709237 M73969 AU156845 L19593 
    AU136738 U11874 C01674 M94582 BI057217 CD695992 CD612009 BE831747 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CXCR2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for CXCR2

    Expression
    for CXCR2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCACTCTATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CXCR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCR2

    SOURCE GeneReport for Unigene cluster: Hs.846
        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCR2 (see all 6): 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Tumor Metastasis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR2

    Orthologs
    for CXCR2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CXCR2 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CXCR21 chemokine (C-X-C motif) receptor 2 61.63(n)
    53.02(a)    		   430652  NM_001031591.1  NP_001026762.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 54(a)
    52(a)
    		 many ↔ many
    many ↔ many
    		 1(88971792-88972871)
    1(88981687-88982766)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7967241 c-X-C chemokine receptor type 1-like 55.49(n)
    45.65(a)    		   796724  XM_001337057.2  XP_001337093.2 


    ENSEMBL Gene Tree for CXCR2 (if available)
    TreeFam Gene Tree for CXCR2 (if available) 

    Paralogs
    for CXCR2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCR2 gene
    CCR62  CCR52  CXCR62  CXCR32  XCR12  CCR92  CCBP22  CCRL22  
    CCR72  CX3CR12  CCR82  CCRL12  CCR42  CXCR12  CCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/63 SIMAP similar genes for CXCR2 using alignment to 5 protein entries:     CXCR2_HUMAN (see all proteins) (see all similar genes):
    IL8RB    CXCR1    CCR2    CCR7    C3AR1    CCR6
    CX3CR1    CCR4    CCBP2    CCR5    CCR8    CCR-5
    AGTR1    CCR3    CMKLR1    CCR9    XCR1    SSTR5

    CXCR2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CXCR2
    PGOHUM00000240523


    Genomic Variants
    for CXCR2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/447 NCBI SNPs in CXCR2 are shown (see all 447)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs46728721,2
    		C,--218988061(+) CTTGGA/GCCCGG 1 -- us2k1 tfbs34Minor allele frequency- G:0.00NA CSA 7
    rs1874205551,2
    		--218988063(+) TGGGCC/TCGGGA 1 -- us2k10--------
    rs1154116891,2
    		F,--218988133(+) GAAAAT/CCTGTC 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs710644121,2
    		C--218988382(-) ATCTCA/-AAAAA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1888753861,2
    		--218988416(+) CTCTTA/GTTACC 1 -- us2k10--------
    rs1172540241,2
    		F,--218988447(+) GATCTC/TGGCTC 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1817419481,2
    		--218988497(+) TCTCAA/GCCTCC 1 -- us2k10--------
    rs1129989231,2
    		C,--218988539(+) ACACCC/TGGCTA 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1497140741,2
    		--218988658(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs1456502721,2
    		--218988669(+) CACCAC/TGCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CXCR2 (218990012 - 219001976 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CXCR2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCR2

    Disorders / Diseases
    for CXCR2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CXCR2 for disorders           About GeneDecksing

    OMIM gene information: 146928    OMIM disorders: --

    20/98 diseases for CXCR2 (see all 98):    About MalaCards
    human granulocytic anaplasmosis    melanoma    hyper-ige syndrome    septicemic plague
    diffuse large b-cell lymphoma    mycosis fungoides    non-small cell lung carcinoma    b-cell lymphomas
    classic kaposi sarcoma    abdominal aortic aneurysm    familial mediterranean fever    aortic aneurysm
    transient cerebral ischemia    gastric cardia adenocarcinoma    chronic obstructive pulmonary disease    biliary tract cancer
    burkitt's lymphoma    essential thrombocythemia    kaposi's sarcoma    cutaneous leishmaniasis

    2 diseases from the University of Copenhagen DISEASES database for CXCR2:
    Chronic obstructive pulmonary disease     Cancer

    10/51 Novoseek disease relationships for CXCR2 gene (see all 51)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 57 18 10542945 (2), 10623425 (1), 10688807 (1), 15598788 (1) (see all 16)
    melanoma 44.1 59 19401689 (5), 19585580 (5), 16393674 (5), 14713106 (5) (see all 27)
    pulmonary disease chronic obstructive 42.6 6 12857718 (1), 15637552 (1), 19026683 (1), 15772681 (1)
    neovascularization 35.2 2 19255141 (1), 15672235 (1)
    leukemia basophilic 32.8 2 15896307 (1), 7578017 (1)
    metastasis 28.8 9 16393674 (2), 11595728 (1), 8363581 (1), 14713106 (1) (see all 7)
    tumors 26.8 54 16210641 (4), 19887480 (3), 19585580 (2), 18096634 (2) (see all 28)
    necrosis 25.8 7 10454826 (1), 10593336 (1), 10950785 (1), 9334359 (1) (see all 7)
    fibrosis idiopathic pulmonary 22.2 3 10902769 (1)
    lung diseases 15.9 2 19026683 (2)

    Human Genome Epidemiology (HuGE) Navigator: CXCR2 (58 documents)

    Export disorders for CXCR2 gene to outside databases

    Publications
    for CXCR2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCR2 gene, integrated from 9 sources (see all 519):
    (articles sorted by number of sources associating them with CXCR2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PubMed id 11196695)1, 2, 9 Kato H.... Tokunaga K. (2000)
    2. Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. (PubMed id 7929358)1, 2, 9 Ahuja S.K.... Murphy P.M. (1994)
    3. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2 q35. (PubMed id 1427896)1, 3, 9 Morris S.W....Cerretti D.P. (1992)
    4. Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor. (PubMed id 9079638)1, 2, 9 Mueller S.G.... Richmond A. (1997)
    5. Characterization of two high affinity human interleukin-8 receptors. (PubMed id 1379593)1, 2, 9 Lee J.... Wood W.I. (1992)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Structure, genomic organization, and expression of the human interleukin-8 receptor B gene. (PubMed id 7512557)1, 2 Sprenger H.... Kelvin D.J. (1994)
    8. Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2. (PubMed id 8384312)1, 2 Cerretti D.P....Beckmann M.P. (1993)
    9. Cloning of complementary DNA encoding a functional human interleukin- 8 receptor. (PubMed id 1891716)1, 2 Murphy P.M. and Tiffany H.L. (1991)
    10. Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts. (PubMed id 16897191)1, 9 Cheong H.S....Park C.S. (2006)

    External Searches for CXCR2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing CXCR2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3579 HGNC: 6027 AceView: IL8RB Ensembl:ENSG00000180871 euGenes: HUgn3579
    ECgene: CXCR2 Kegg: 3579 H-InvDB: CXCR2

    Other Databases showing CXCR2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXCR2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCR2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXC_chemokine_receptors
    SeattleSNPshttp://pga.gs.washington.edu/data/il8rb/

    Intellectual Property
    for CXCR2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CXCR2 gene:
    Search GeneIP for patents involving CXCR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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