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CXCR1 Gene

protein-coding   GIFtS: 67
GCID: GC02M219028

Chemokine (C-X-C Motif) Receptor 1

(Previous names: interleukin 8 receptor, alpha)
(Previous symbols: CMKAR1, IL8RA)
  See CXCR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Receptor 11 2     C-C-CKR-12
IL8RA1 2 3 5     CD1282
CMKAR11 2 3     CD1812
Interleukin 8 Receptor, Alpha1 2     CKR-12
High Affinity Interleukin-8 Receptor A2 3     IL8R12
CDw128a2 3     IL8RBA2
CXC-R12 3     C-X-C Chemokine Receptor Type 12
CXCR-12 3     Interleukin-8 Receptor Type 12
IL-8 Receptor Type 12 3     Interleukin-8 Receptor Type A2
IL-8R A2 3     CD181 Antigen3
C-C2     

External Ids:    HGNC: 60261   Entrez Gene: 35772   Ensembl: ENSG000001634647   OMIM: 1469295   UniProtKB: P250243   

Export aliases for CXCR1 gene to outside databases

Previous GC identifers: GC02M218736 GC02M210880


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCR1 Gene:
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor
for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein
activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic
oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high
affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to
chromosome 2q33-q36. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCR1 Gene:
CXCR1 (chemokine (C-X-C motif) receptor 1) is a protein-coding gene. Diseases associated with CXCR1 include acute pyelonephritis, and chronic nk-cell lymphocytosis. GO annotations related to this gene include interleukin-8 binding and G-protein coupled receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CXCR1_HUMAN, P25024
Function: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the
receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a
phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to
MGSA (GRO) with a low affinity

summary for CXCR1 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CXCR1 (Interleukin 8 receptor, alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CXCR1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCR1 promoter sequence
   Search Chromatin IP Primers for CXCR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CXCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCR1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M219028:  view genomic region     (about GC identifiers)

Start:
219,027,568 bp from pter      End:
219,031,718 bp from pter
Size:
4,151 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CXCR1_HUMAN, P25024 (See protein sequence)
Recommended Name: C-X-C chemokine receptor type 1  
Size: 350 amino acids; 39791 Da
3 PDB 3D structures from and Proteopedia for CXCR1:
1ILP (3D)        1ILQ (3D)        2LNL (3D)    
Secondary accessions: B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8
Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2

Explore the universe of human proteins at neXtProt for CXCR1: NX_P25024

Explore proteomics data for CXCR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3, Asn16
  • Modification sites at PhosphoSitePlus

  • See CXCR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000625.1  
    ENSEMBL proteins: 
     ENSP00000295683  
    Reactome Protein details: P25024

    CXCR1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CXCR1
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    Novus Biologicals CXCR1 Protein
    Novus Biologicals CXCR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CXCR1 

    CXCR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CXCR1 (CXCR1/IL-8 RA)
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CXCR1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors
    CXCR: GPCR / Class A : Chemokine receptors : C-X-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CXCR1
    Chemokine receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000174 Chemokine_CXCR_1/2
     IPR001355 Chemokine_CXCR1
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P25024

    ProtoNet protein and cluster: P25024

    2 Blocks protein domains:
    IPB000174 Interleukin-8 receptor signature
    IPB001355 Interleukin 8A receptor signature


    UniProtKB/Swiss-Prot: CXCR1_HUMAN, P25024
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CXCR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCR1_HUMAN, P25024
    Function: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the
    receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a
    phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to
    MGSA (GRO) with a low affinity

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004918interleukin-8 receptor activity IDA10734056
    GO:0004930G-protein coupled receptor activity TAS8381837
    GO:0004950chemokine receptor activity TAS1840701
    GO:0019959interleukin-8 binding IPI11564821
         
    Find genes that share ontologies with CXCR1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cxcr1):
     normal 

    Find genes that share phenotypes with CXCR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cxcr1tm1Dgen for CXCR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CXCR1:
    hsa-mir-335-5p (MIRT017488), hsa-mir-26b-5p (MIRT029277)

    Block miRNA regulation of human, mouse, rat CXCR1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CXCR1:
    hsa-miR-513b hsa-miR-509-5p hsa-miR-4268 hsa-miR-509-3-5p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidCXCR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CXCR1
    Predesigned siRNA for gene silencing in human, mouse, rat CXCR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CXCR1

    Clone
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    GenScript: all cDNA clones in your preferred vector: CXCR1 (NM_000634)
    Sino Biological Human cDNA Clone for CXCR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCR1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for CXCR1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXCR1_HUMAN, P25024: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS10725748
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CXCR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXCR1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51


    Find genes that share SuperPaths with CXCR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CXCR1
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCR1 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    3 GeneGo (Thomson Reuters) Pathways for CXCR1
        Cell adhesion ECM remodeling
    Inhibitory action of Lipoxins on Superoxide production in neutrophils
    Inhibitory action of Lipoxins on neutrophil migration

    3 BioSystems Pathways for CXCR1
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    2 Reactome Pathways for CXCR1
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    4 Kegg Pathways  (Kegg details for CXCR1):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Endocytosis
    Epithelial cell signaling in Helicobacter pylori infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCR1 (see all 6): 
              G Protein Coupled Receptors 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CXCR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CXCR1 (P250243 ENSP000002956834) via UniProtKB, MINT, STRING, and/or I2D (see all 198)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL8P101453, ENSP000003065124I2D: score=4 STRING: ENSP00000306512
    CXCR2P250253, ENSP000003196354I2D: score=3 STRING: ENSP00000319635
    GNA15P306793, ENSP000002629584I2D: score=2 STRING: ENSP00000262958
    ADRA1AP353483, ENSP000003699604I2D: score=1 STRING: ENSP00000369960
    GNA14O958373, ENSP000003658074I2D: score=1 STRING: ENSP00000365807
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002407dendritic cell chemotaxis TAS16621978
    GO:0006935chemotaxis TAS10725748
    GO:0006954inflammatory response TAS10725748
    GO:0007166cell surface receptor signaling pathway IDA10734056
    GO:0007186G-protein coupled receptor signaling pathway TAS8381837

    Find genes that share ontologies with CXCR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CXCR1
      Browse compounds at ApexBio 

    Compounds for CXCR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

    1 HMDB Compound for CXCR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CXCR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ketoprofen-- 22071-15-4targetother15974585 11331079 9093816

    7 IUPHAR Ligands for CXCR1 (CXCR1)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]CXCL8 (human)
    AgonistFull agonist8.9 - 9.610188995 12626541
    CXCL8
    AgonistFull agonist8.8 - 9.51379593 15946947 15282370 10188995 8940121
    mini-TyrRS
    AgonistFull agonist8.110102815
    [125I]mini-TyrRS
    AgonistFull agonist7.710102815
    CXCL6
    AgonistFull agonist79692902
    CXCL1
    AgonistFull agonist6.41379593
    cytokine domain of tyrosyl tRNA synthetase
    AgonistAgonist6.4--

    Selected Novoseek inferred chemical compound relationships for CXCR1 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    groalpha 88.1 14 9195914 (2), 10188995 (2), 15561756 (2), 15476666 (1) (see all 10)
    grogamma 80.7 2 20044480 (1), 11808935 (1)
    rantes 76.2 19 1699135 (2), 11776150 (2), 7515718 (1), 7642634 (1) (see all 16)
    grobeta 74.2 2 20044480 (1), 11808935 (1)
    fmlp 65.8 18 8699129 (3), 9553132 (2), 9933081 (1), 9013980 (1) (see all 11)
    leukotriene b4 50 2 11994504 (1), 10233431 (1)
    calcium 47.6 32 8903513 (3), 1379593 (2), 10188995 (2), 10206993 (2) (see all 23)
    tarc 40.7 1 19538461 (1)
    phosphoinositide 37 1 12594210 (1)
    phycoerythrin 27.6 3 15008605 (1), 7706709 (1)



    Find genes that share compounds with CXCR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CXCR1 gene: 
    NM_000634.2  

    Unigene Cluster for CXCR1:

    Chemokine (C-X-C motif) receptor 1
    Hs.194778  [show with all ESTs]
    Unigene Representative Sequence: NM_000634
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295683(uc002vhc.3)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCXCR1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: CXCR1 (NM_000634)
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    Primer
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    OriGene qPCR primer pairs and template standards for CXCR1
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCR1
      QuantiTect SYBR Green Assays in human, mouse, rat CXCR1
      QuantiFast Probe-based Assays in human, mouse, rat CXCR1

    Additional mRNA sequence: 

    AK298647.1 AK309632.1 AK312668.1 BC028221.1 BC072397.1 CR541994.1 CR542029.1 L19591.1 
    M68932.1 U11871.1 

    1 DOTS entry:

    DT.208250 

    16 AceView cDNA sequences:

    CR542029 CR541994 BF001579 L19591 CR617846 U11871 AU100346 M68932 
    NM_000634 CA425329 BM922807 AL531903 BC028221 BC072397 BX431796 AL564211 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CXCR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGCCACC
    CXCR1 Expression
    About this image


    CXCR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
    CXCR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXCR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194778
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCR1 (see all 6): 
              G Protein Coupled Receptors 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CXCR1
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    QuantiFast Probe-based Assays in human, mouse, rat CXCR1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXCR1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcr11 , 5 chemokine (C-X-C motif) receptor 11, 5 75.75(n)1
    68.56(a)1
      1 (38.44 cM)5
    2272881  NM_178241.41  NP_839972.11 
     741917855 
    chicken
    (Gallus gallus)
    Aves CXCR21 chemokine (C-X-C motif) receptor 2 62.12(n)
    53.24(a)
      430652  NM_001031591.1  NP_001026762.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    57(a)
    56(a)
    many ↔ many
    many ↔ many
    1(88971792-88972871)
    1(88981687-88982766)
    African clawed frog
    (Xenopus laevis)
    Amphibia CXCR22 CXCR2 like protein 76.43(n)    AJ312936.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CXCR16
    chemokine (C-X-C motif) receptor 1
    43(a)
    1 → many
    9(49095701-49096732) ENSDARG00000054975


    ENSEMBL Gene Tree for CXCR1 (if available)
    TreeFam Gene Tree for CXCR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CXCR1 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    CCR72  ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CXCR1 using alignment to 1 protein entry:     CXCR1_HUMAN(see all similar genes):
    IL8RB    CXCR2    CCR6    CCR7    CCR2    BDKRB1
    CCR4    CXCR4    CCR5    ACKR2    CCBP2    CCR9
    CX3CR1    AGTR1    ACKR3    ACKR4    BLR1    CCR1

    Find genes that share paralogs with CXCR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXCR1 (see all 211)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444121201,2
    --218410894(+) CCCAAA/GCTGCC 1 -- ds50010--------
    rs1819498401,2
    --218411004(+) CCAACC/TTCAAG 1 -- ds50010--------
    rs1873920191,2
    --218411206(+) AGGCTA/GAAAGC 1 -- ds50010--------
    rs28543861,2
    C,F,A,H--218411215(-) GTCCTG/CTCCGC 1 -- ds500132Minor allele frequency- C:0.17NA NS EA MN WA CSA 1938
    rs1478363111,2
    --218411262(+) AGTGGC/TCTTTT 1 -- ds50010--------
    rs30929691,2
    C,F,H--218411276(-) ATGAAT/CGCATG 1 -- ds500124Minor allele frequency- C:0.05NA NS MN EA CSA WA 2026
    rs28543851,2
    C,H--218411343(-) GGTTTA/GTTCAC 1 -- ut31 ese39Minor allele frequency- G:0.00MN NS EA 820
    rs178386101,2
    C,F,H--218411426(-) CTCACC/AAGTCC 1 -- ut31 ese314Minor allele frequency- A:0.07NS NA MN CSA WA 1534
    rs30929701,2
    C,F,H--218411501(-) AGCTTC/AACCCT 1 -- ut31 ese312Minor allele frequency- A:0.04NA NS EA WA 1342
    rs28543841,2
    H--218411524(-) GAAATG/CCTCCT 1 -- ut314Minor allele frequency- C:0.00NS EA 416

    HapMap Linkage Disequilibrium report for CXCR1 (219027568 - 219031718 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3164CNV Insertion18451855

    Human Gene Mutation Database (HGMD): CXCR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146929   
    OMIM disorders: 609423  
    Selected diseases for CXCR1 (see all 21):    
    About MalaCards
    acute pyelonephritis    chronic nk-cell lymphocytosis    denture stomatitis    idiopathic pulmonary alveolar proteinosis
    aids, slow progression to    anterior uveitis    gastric cardia adenocarcinoma    idiopathic anterior uveitis
    pyelonephritis    bacteriuria    uveitis    pulmonary disease, chronic obstructive
    hyper ige syndrome    adenomyosis    lymphoid leukemia    h. pylori infection
    visceral leishmaniasis    mycosis fungoides    leishmaniasis    tuberculosis

    3 diseases from the University of Copenhagen DISEASES database for CXCR1:
    Pyelonephritis     Chronic NK-cell lymphocytosis     Denture stomatitis

    Find genes that share disorders with CXCR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CXCR1 gene (see all 63)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 59.6 20 16982101 (2), 8947914 (1), 10623425 (1), 10688807 (1) (see all 18)
    melanoma 45.2 47 14713106 (6), 19401689 (5), 19585580 (5), 19683430 (3) (see all 17)
    urinary tract infection recurrent 43.1 5 16339057 (3), 17942281 (1)
    acute pyelonephritis 41.1 4 17786197 (1), 11404374 (1), 16339057 (1)
    leukemia basophilic 39 2 15896307 (1)
    necrosis 33.3 17 10090924 (2), 10454826 (1), 15451491 (1), 10556424 (1) (see all 12)
    tumors 26.9 35 9568059 (2), 19585580 (2), 16393674 (2), 10090924 (2) (see all 25)
    pulmonary disease chronic obstructive 23.2 4 15772681 (2), 12857718 (1), 15637552 (1)
    b-all 22.5 1 16118018 (1)
    psoriasis 20.4 6 9424095 (2), 1361277 (2), 10653603 (1), 12823305 (1)

    Genetic Association Database (GAD): CXCR1
    Human Genome Epidemiology (HuGE) Navigator: CXCR1 (50 documents)

    Export disorders for CXCR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXCR1 gene, integrated from 10 sources (see all 513):
    (articles sorted by number of sources associating them with CXCR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils. (PubMed id 16205979)1, 2, 9 Liu Y.... Su B. (J. Mol. Evol. 2005)
    2. Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PubMed id 11196695)1, 2, 9 Kato H.... Tokunaga K. (Genes Immun. 2000)
    3. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. (PubMed id 1427896)1, 3, 9 Morris S.W....Cerretti D.P. (Genomics 1992)
    4. Characterization of two high affinity human interleukin-8 receptors. (PubMed id 1379593)1, 2, 9 Lee J.... Wood W.I. (J. Biol. Chem. 1992)
    5. Structure of a CXC chemokine-receptor fragment in complex with interleukin-8. (PubMed id 10368283)1, 2, 9 Skelton N.J.... Lowman H. (Structure 1999)
    6. Structure and functional expression of a human interleukin-8 receptor. (PubMed id 1840701)1, 2, 9 Holmes W.E.... Wood W.I. (Science 1991)
    7. Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. (PubMed id 20016852)1, 4 Hawn T.R....Hooton T.M. (PLoS ONE 2009)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. (PubMed id 7929358)1, 2 Ahuja S.K.... Murphy P.M. (J. Biol. Chem. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3577 HGNC: 6026 AceView: IL8RA Ensembl:ENSG00000163464 euGenes: HUgn3577
    ECgene: CXCR1 Kegg: 3577 H-InvDB: CXCR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXCR1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXC_chemokine_receptors
    SeattleSNPshttp://pga.gs.washington.edu/data/il8ra/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXCR1 gene:
    Search GeneIP for patents involving CXCR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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