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Aliases for CXCR1 Gene

Aliases for CXCR1 Gene

  • Chemokine (C-X-C Motif) Receptor 1 2 3
  • High Affinity Interleukin-8 Receptor A 3 4
  • Interleukin 8 Receptor, Alpha 2 3
  • IL-8 Receptor Type 1 3 4
  • IL-8R A 3 4
  • CDw128a 3 4
  • CMKAR1 3 4
  • CXC-R1 3 4
  • CXCR-1 3 4
  • IL8RA 3 4
  • Interleukin-8 Receptor Type 1 3
  • Interleukin-8 Receptor Type A 3
  • CD181 Antigen 4
  • C-C-CKR-1 3
  • IL8RBA 3
  • CKR-1 3
  • CD128 3
  • CD181 3
  • IL8R1 3
  • C-C 3

External Ids for CXCR1 Gene

Previous HGNC Symbols for CXCR1 Gene

  • CMKAR1
  • IL8RA

Previous GeneCards Identifiers for CXCR1 Gene

  • GC02M218736
  • GC02M219028
  • GC02M210880

Summaries for CXCR1 Gene

Entrez Gene Summary for CXCR1 Gene

  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

GeneCards Summary for CXCR1 Gene

CXCR1 (Chemokine (C-X-C Motif) Receptor 1) is a Protein Coding gene. Diseases associated with CXCR1 include chronic nk-cell lymphocytosis and denture stomatitis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include G-protein coupled receptor activity and interleukin-8 binding. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CXCR1 Gene

  • Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity

Gene Wiki entry for CXCR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR1 Gene

Genomics for CXCR1 Gene

Genomic Location for CXCR1 Gene

Chromosome:
2
Start:
218,162,845 bp from pter
End:
218,166,995 bp from pter
Size:
4,151 bases
Orientation:
Minus strand

Genomic View for CXCR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR1 Gene

No data available for Regulatory Elements for CXCR1 Gene

Proteins for CXCR1 Gene

  • Protein details for CXCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25024-CXCR1_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 1
    Protein Accession:
    P25024
    Secondary Accessions:
    • B2R6Q3
    • Q2YEF8
    • Q2YEG4
    • Q2YEG5
    • Q2YEG7
    • Q2YEG8
    • Q53R18
    • Q6IN95
    • Q8N6T6
    • Q9P2T8
    • Q9P2T9
    • Q9P2U0
    • Q9P2U1
    • Q9P2U2

    Protein attributes for CXCR1 Gene

    Size:
    350 amino acids
    Molecular mass:
    39791 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCR1 Gene

neXtProt entry for CXCR1 Gene

Proteomics data for CXCR1 Gene at MOPED

Post-translational modifications for CXCR1 Gene

  • Glycosylation at Asn 3 and Asn 16
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCR1 (CXCR1/IL-8 RA)

No data available for DME Specific Peptides for CXCR1 Gene

Domains & Families for CXCR1 Gene

Graphical View of Domain Structure for InterPro Entry

P25024

UniProtKB/Swiss-Prot:

CXCR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR1: view

Function for CXCR1 Gene

Molecular function for CXCR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity

Gene Ontology (GO) - Molecular Function for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004918 interleukin-8 receptor activity IDA 10734056
GO:0004930 G-protein coupled receptor activity TAS 8381837
GO:0004950 chemokine receptor activity TAS 1840701
GO:0019959 interleukin-8 binding IPI 11564821
genes like me logo Genes that share ontologies with CXCR1: view

Phenotypes for CXCR1 Gene

MGI mutant phenotypes for CXCR1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CXCR1: view

Animal Models for CXCR1 Gene

MGI Knock Outs for CXCR1:

Animal Model Products

miRNA for CXCR1 Gene

miRTarBase miRNAs that target CXCR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CXCR1 Gene

Localization for CXCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCR1 Gene COMPARTMENTS Subcellular localization image for CXCR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 10725748
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CXCR1: view

Pathways & Interactions for CXCR1 Gene

genes like me logo Genes that share pathways with CXCR1: view

PCR Array Products

SIGNOR curated interactions for CXCR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006935 chemotaxis TAS 10725748
GO:0006954 inflammatory response TAS 10725748
GO:0007166 cell surface receptor signaling pathway IDA 10734056
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with CXCR1: view

Drugs & Compounds for CXCR1 Gene

(28) Drugs for CXCR1 Gene - From: NovoSeek, IUPHAR, DGIdb, Tocris, ApexBio, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ketoprofen Approved Pharma Inhibition, Inhibitor, Target, other 74
Maraviroc Approved, Investigational Pharma Antagonist Selective CCR5 antagonist,antiretroviral agent, Selective CCR5 antagonist 0
Dexamethasone Approved, Investigational Pharma Agonist 1806
Bestatin Experimental Pharma Inhibition, Inhibitor Aminopeptidase inhibitor 0
arachidonic acid Experimental Nutra Potentiation, Activator 27

(28) Additional Compounds for CXCR1 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
DAPTA
106362-34-9
FC 131
606968-52-9
IT1t dihydrochloride
1092776-63-0
Actinomycin D
cacl2
genes like me logo Genes that share compounds with CXCR1: view

Drug Products

Transcripts for CXCR1 Gene

mRNA/cDNA for CXCR1 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCR1 Gene

Chemokine (C-X-C motif) receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR1 Gene

No ASD Table

Relevant External Links for CXCR1 Gene

GeneLoc Exon Structure for
CXCR1
ECgene alternative splicing isoforms for
CXCR1

Expression for CXCR1 Gene

mRNA expression in normal human tissues for CXCR1 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR1 Gene

This gene is overexpressed in Whole Blood (x50.8).

SOURCE GeneReport for Unigene cluster for CXCR1 Gene Hs.194778

genes like me logo Genes that share expression patterns with CXCR1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CXCR1 Gene

Orthologs for CXCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cxcr1 35
  • 75.75 (n)
  • 68.56 (a)
Cxcr1 16
Cxcr1 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CXCR1 35
  • 99.52 (n)
  • 98.86 (a)
CXCR1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcr1 35
  • 75.64 (n)
  • 71.25 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CXCR2 35
  • 62.12 (n)
  • 53.24 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia CXCR2 35
zebrafish
(Danio rerio)
Actinopterygii CXCR1 36
  • 43 (a)
OneToMany
Species with no ortholog for CXCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCR1 Gene

ENSEMBL:
Gene Tree for CXCR1 (if available)
TreeFam:
Gene Tree for CXCR1 (if available)

Paralogs for CXCR1 Gene

genes like me logo Genes that share paralogs with CXCR1: view

Variants for CXCR1 Gene

Sequence variations from dbSNP and Humsavar for CXCR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs885816 -- 218,165,926(-) GGAAA(A/T)ATATT intron-variant
rs1805038 - 218,165,001(-) TCGGC(C/T)GCTCC reference, missense
rs2234671 - 218,164,385(-) GGAGA(C/G)CTGTG missense, reference
rs2285021 -- 218,166,433(-) tgaga(G/T)ggagt intron-variant
rs2671222 -- 218,167,879(-) AAGCC(A/G)TTCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXCR1 Gene

Variant ID Type Subtype PubMed ID
nsv3164 CNV Insertion 18451855

Variation tolerance for CXCR1 Gene

Residual Variation Intolerance Score: 89.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCR1 Gene

HapMap Linkage Disequilibrium report
CXCR1
Human Gene Mutation Database (HGMD)
CXCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR1 Gene

Disorders for CXCR1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CXCR1 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
chronic nk-cell lymphocytosis
  • nk-cell large granular lymphocyte lymphocytosis
denture stomatitis
  • denture stomatitis [ambiguous]
acute pyelonephritis
  • acute pyelonephritis nos
idiopathic anterior uveitis
  • anterior uveitis idiopathic
bacteriuria
- elite association
Search CXCR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCR1

Genetic Association Database (GAD)
CXCR1
Human Genome Epidemiology (HuGE) Navigator
CXCR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCR1
genes like me logo Genes that share disorders with CXCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR1 Gene

Publications for CXCR1 Gene

  1. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. (PMID: 1427896) Morris S.W. … Cerretti D.P. (Genomics 1992) 2 23 67
  2. The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours. (PMID: 20005738) Hussain F. … El-Bahrawy M. (Cytokine 2010) 23 67
  3. Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion. (PMID: 19585580) Singh S. … Singh R.K. (Int. J. Cancer 2010) 23 67
  4. Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients. (PMID: 20005258) Mintz R. … Ben-Baruch A. (Immunol. Lett. 2010) 23 67
  5. The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist. (PMID: 20044480) LA1ttichau H.R. (J. Biol. Chem. 2010) 23 67

Products for CXCR1 Gene

Sources for CXCR1 Gene

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