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Aliases for CXCR1 Gene

Aliases for CXCR1 Gene

  • C-X-C Motif Chemokine Receptor 1 2 3 5
  • High Affinity Interleukin-8 Receptor A 3 4
  • Chemokine (C-X-C Motif) Receptor 1 2 3
  • Interleukin 8 Receptor, Alpha 2 3
  • IL-8 Receptor Type 1 3 4
  • IL-8R A 3 4
  • CDw128a 3 4
  • CMKAR1 3 4
  • CXC-R1 3 4
  • CXCR-1 3 4
  • IL8RA 3 4
  • C-X-C Chemokine Receptor Type 1 3
  • Interleukin-8 Receptor Type 1 3
  • Interleukin-8 Receptor Type A 3
  • CD181 Antigen 4
  • C-C-CKR-1 3
  • IL8RBA 3
  • CKR-1 3
  • CD128 3
  • CD181 3
  • IL8R1 3
  • C-C 3

External Ids for CXCR1 Gene

Previous HGNC Symbols for CXCR1 Gene

  • CMKAR1
  • IL8RA

Previous GeneCards Identifiers for CXCR1 Gene

  • GC02M218736
  • GC02M219028
  • GC02M210880

Summaries for CXCR1 Gene

Entrez Gene Summary for CXCR1 Gene

  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

GeneCards Summary for CXCR1 Gene

CXCR1 (C-X-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CXCR1 include Hiv-1 and Acute Pyelonephritis. Among its related pathways are Peptide ligand-binding receptors and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include G-protein coupled receptor activity and interleukin-8 binding. An important paralog of this gene is CXCR2.

UniProtKB/Swiss-Prot for CXCR1 Gene

  • Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Gene Wiki entry for CXCR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR1 Gene

Genomics for CXCR1 Gene

Regulatory Elements for CXCR1 Gene

Enhancers for CXCR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G218145 0.9 FANTOM5 50.4 +21.7 21670 0.3 CTCF NFIB CEBPG RAD21 GATAD1 THAP11 GATAD2A ZNF263 NFIA FOXA3 CXCR2 CXCR1 ENSG00000261338 TNS1 SLC11A1 CTDSP1 ARPC2 GC02P218136
GH02G218156 0.5 FANTOM5 53.9 +10.7 10714 0.3 CTCF CEBPB CXCR1 CXCR2 ENSG00000261338 CTDSP1 SLC11A1 ARPC2 GC02P218136
GH02G218228 1.4 Ensembl ENCODE dbSUPER 10.7 -63.2 -63228 3.7 HDGF YY1 GATA2 EGR1 SCRT2 FOS ETV6 IKZF2 CREM SP5 ENSG00000261338 GPBAR1 AAMP CXCR1 CATIP-AS1 GC02M218215 TRY-ATA1-1
GH02G218124 1 Ensembl ENCODE 10.3 +40.7 40744 3.5 CTCF RNF2 MIER1 SUZ12 ZMYM3 CBX2 TEAD2 MIER2 REST MNT ENSG00000261338 CXCR1 CXCR2 GC02P218134 GC02P218135
GH02G218366 1.6 FANTOM5 ENCODE dbSUPER 5.1 -202.9 -202881 6.8 HDGF ATF1 CREB3L1 SIN3A YY1 ETS1 ZNF143 ZNF207 ZNF263 PAF1 SLC11A1 ENSG00000261338 ARPC2 CXCR2 CXCR1 CATIP PNKD CNOT9 TMBIM1 USP37
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXCR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCR1 Gene

Chromosome:
2
Start:
218,162,845 bp from pter
End:
218,166,995 bp from pter
Size:
4,151 bases
Orientation:
Minus strand

Genomic View for CXCR1 Gene

Genes around CXCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR1 Gene

Proteins for CXCR1 Gene

  • Protein details for CXCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25024-CXCR1_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 1
    Protein Accession:
    P25024
    Secondary Accessions:
    • B2R6Q3
    • Q2YEF8
    • Q2YEG4
    • Q2YEG5
    • Q2YEG7
    • Q2YEG8
    • Q53R18
    • Q6IN95
    • Q8N6T6
    • Q9P2T8
    • Q9P2T9
    • Q9P2U0
    • Q9P2U1
    • Q9P2U2

    Protein attributes for CXCR1 Gene

    Size:
    350 amino acids
    Molecular mass:
    39791 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCR1 Gene

neXtProt entry for CXCR1 Gene

Post-translational modifications for CXCR1 Gene

  • Glycosylation at isoforms=3 and isoforms=16
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCR1 Gene

Domains & Families for CXCR1 Gene

Graphical View of Domain Structure for InterPro Entry

P25024

UniProtKB/Swiss-Prot:

CXCR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR1: view

Function for CXCR1 Gene

Molecular function for CXCR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Gene Ontology (GO) - Molecular Function for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004918 interleukin-8 receptor activity IDA 10734056
GO:0004930 G-protein coupled receptor activity TAS 8381837
GO:0004950 chemokine receptor activity TAS 1840701
GO:0016494 C-X-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CXCR1: view
genes like me logo Genes that share phenotypes with CXCR1: view

Animal Models for CXCR1 Gene

MGI Knock Outs for CXCR1:

Animal Model Products

CRISPR Products

miRNA for CXCR1 Gene

miRTarBase miRNAs that target CXCR1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CXCR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCR1 Gene

Localization for CXCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 10725748
GO:0016021 integral component of membrane IEA --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with CXCR1: view

Pathways & Interactions for CXCR1 Gene

genes like me logo Genes that share pathways with CXCR1: view

SIGNOR curated interactions for CXCR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006935 chemotaxis TAS 10725748
GO:0006954 inflammatory response TAS 10725748
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IDA 10734056
genes like me logo Genes that share ontologies with CXCR1: view

Drugs & Compounds for CXCR1 Gene

(32) Drugs for CXCR1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ketoprofen Approved, Vet_approved Pharma Inhibition, Inhibitor, Target, other 87
[<sup>125</sup>I]CXCL8 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]mini-TyrRS Pharma Full agonist, Agonist 0
CXCL1 Pharma Full agonist, Agonist 0
CXCL6 Pharma Full agonist, Agonist 0

(21) Additional Compounds for CXCR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(6) ApexBio Compounds for CXCR1 Gene

Compound Action Cas Number
Plerixafor 8HCl (AMD3100 8HCl) CXCR4 antagonist 155148-31-5
Reparixin Inhibitor of CXCL8 receptor and CXCR1/CXCR2 activation 266359-83-5
Reparixin L-lysine salt CXCR1/CXCR2 inhibitor 266359-93-7
SCH 527123 CXCR1 and CXCR2 receptors antagonist 473727-83-2
SCH 563705 CXCR2/CXCR1 antagonist,potent 473728-58-4
WZ811 Competitive CXR4 antagonist,highly potent 55778-02-4
genes like me logo Genes that share compounds with CXCR1: view

Drug Products

Transcripts for CXCR1 Gene

mRNA/cDNA for CXCR1 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCR1 Gene

Chemokine (C-X-C motif) receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CXCR1

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR1 Gene

No ASD Table

Relevant External Links for CXCR1 Gene

GeneLoc Exon Structure for
CXCR1
ECgene alternative splicing isoforms for
CXCR1

Expression for CXCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCR1 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR1 Gene

This gene is overexpressed in Whole Blood (x50.8).

NURSA nuclear receptor signaling pathways regulating expression of CXCR1 Gene:

CXCR1

SOURCE GeneReport for Unigene cluster for CXCR1 Gene:

Hs.194778

Evidence on tissue expression from TISSUES for CXCR1 Gene

  • Blood(5)
  • Spleen(2.7)
  • Intestine(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with CXCR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCR1 Gene

Orthologs for CXCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCR1 34 35
  • 99.52 (n)
mouse
(Mus musculus)
Mammalia Cxcr1 34 16 35
  • 75.75 (n)
rat
(Rattus norvegicus)
Mammalia Cxcr1 34
  • 75.64 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CXCR2 34
  • 62.12 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 57 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia CXCR2 34
zebrafish
(Danio rerio)
Actinopterygii CXCR1 35
  • 43 (a)
OneToMany
Species where no ortholog for CXCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCR1 Gene

ENSEMBL:
Gene Tree for CXCR1 (if available)
TreeFam:
Gene Tree for CXCR1 (if available)

Paralogs for CXCR1 Gene

Variants for CXCR1 Gene

Sequence variations from dbSNP and Humsavar for CXCR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000800851 -- 218,163,151(+) AGGAG(C/G/T)TTCTG utr-variant-3-prime
rs1000827249 -- 218,162,806(+) GAGCA(C/G)ATGGT downstream-variant-500B
rs1000982366 -- 218,167,682(+) GAACA(C/T)AAACC upstream-variant-2KB
rs1001165300 -- 218,164,192(+) GAAGA(A/C)GTGTA reference, synonymous-codon
rs1001459719 -- 218,168,821(+) TGCTT(C/T)GCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXCR1 Gene

Variant ID Type Subtype PubMed ID
esv3594329 CNV gain 21293372
esv3594330 CNV gain 21293372
nsv3164 CNV insertion 18451855

Variation tolerance for CXCR1 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCR1 Gene

Human Gene Mutation Database (HGMD)
CXCR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR1 Gene

Disorders for CXCR1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CXCR1 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
acute pyelonephritis
  • acute pyelonephritis nos
idiopathic anterior uveitis
  • anterior uveitis idiopathic
bacteriuria
acute cystitis
  • urinary tract infection
- elite association - COSMIC cancer census association via MalaCards
Search CXCR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCR1

Genetic Association Database (GAD)
CXCR1
Human Genome Epidemiology (HuGE) Navigator
CXCR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCR1
genes like me logo Genes that share disorders with CXCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR1 Gene

Publications for CXCR1 Gene

  1. Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils. (PMID: 16205979) Liu Y. … Su B. (J. Mol. Evol. 2005) 3 4 22 64
  2. Characterization of two high affinity human interleukin-8 receptors. (PMID: 1379593) Lee J. … Wood W.I. (J. Biol. Chem. 1992) 3 4 22 64
  3. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. (PMID: 1427896) Morris S.W. … Cerretti D.P. (Genomics 1992) 2 3 22 64
  4. The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist. (PMID: 20044480) LA1ttichau H.R. (J. Biol. Chem. 2010) 3 22 64
  5. Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion. (PMID: 19585580) Singh S. … Singh R.K. (Int. J. Cancer 2010) 3 22 64

Products for CXCR1 Gene

  • Addgene plasmids for CXCR1

Sources for CXCR1 Gene

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