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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CXCR1 Gene

protein-coding GIFtS: 64
GCID: GC02M219028

chemokine (C-X-C motif) receptor 1

(Previous names: interleukin 8 receptor, alpha )
(Previous symbols: CMKAR1, IL8RA)

Explore 99 diseases affiliated with
CXCR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Receptor 1¹ ²		IL-8R A² ³
IL8RA¹ ² ³ ⁵		C-C²
CDw128a¹ ² ³		C-C-CKR-1²
CMKAR1¹ ² ³		CD128²
CD181¹ ²		IL8R1²
CKR-1¹ ²		IL8RBA²
Interleukin 8 Receptor, Alpha¹ ²		C-X-C Chemokine Receptor Type 1²
High Affinity Interleukin-8 Receptor A² ³		Interleukin-8 Receptor Type 1²
CXC-R1² ³		Interleukin-8 Receptor Type A²
CXCR-1² ³		CD181 Antigen³
IL-8 Receptor Type 1² ³

External Ids:	HGNC: 6026¹	Entrez Gene: 3577²	Ensembl: ENSG00000163464⁷	OMIM: 146929⁵	UniProtKB: P25024³

Export aliases for CXCR1 gene to outside databases

Previous GC identifers: GC02M218736 GC02M210880

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CXCR1:

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for

interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated

second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte

precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor,

as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CXCR1_HUMAN, P25024

Function: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the

receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a

phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA

(GRO) with a low affinity

Gene Wiki entry for CXCR1 (Interleukin 8 receptor, alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for CXCR1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCR1 promoter sequence

Search SABiosciences Chromatin IP Primers for CXCR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35

CXCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCR1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M219028: view genomic region (about GC identifiers)

Start:	219,027,568 bp from pter	End:	219,031,718 bp from pter
Size:	4,151 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CXCR1_HUMAN, P25024 (See protein sequence)

Recommended Name: C-X-C chemokine receptor type 1

Size: 350 amino acids; 39791 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

3 PDB 3D structures from and Proteopedia for CXCR1:

1ILP (3D)

1ILQ (3D)

2LNL (3D)

Secondary accessions: B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9

Q9P2U0 Q9P2U1 Q9P2U2

Explore the universe of human proteins at neXtProt for CXCR1: NX_P25024

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P25024

CXCR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000625.1

ENSEMBL proteins:

ENSP00000295683

Reactome Protein details: P25024
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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	TAS	10725748
GO:0016021	integral to membrane	IEA	--

CXCR1 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CXCR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000174 Chemokine_CXCR

IPR001355 Chemokine_CXCR1

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P25024

ProtoNet protein and cluster: P25024

2 Blocks protein families:

IPB000174 Interleukin-8 receptor signature

IPB001355 Interleukin 8A receptor signature

UniProtKB/Swiss-Prot: CXCR1_HUMAN, P25024

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CXCR1_HUMAN, P25024

Function: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the

receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a

phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA

(GRO) with a low affinity

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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCR1:
		hsa-miR-513b hsa-miR-509-5p hsa-miR-4268 hsa-miR-509-3-5p hsa-miR-4267
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCR1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004918	interleukin-8 receptor activity	IDA	10734056
GO:0004930	G-protein coupled receptor activity	TAS	8381837
GO:0004950	chemokine receptor activity	TAS	1840701
GO:0019959	interleukin-8 binding	IPI	11564821

CXCR1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Cxcr1^tm1Dgen for CXCR1
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cxcr1):

normal

CXCR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Cell adhesion_ECM remodeling

Cell adhesion ECM remodeling

1.00

Cell adhesion_ECM remodeling

1.00

Inhibitory action of Lipoxins on Superoxide production in neutrophils

Inhibitory action of Lipoxins on Superoxide production in neutrophils

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CXCR1

	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
	Cell adhesion ECM remodeling

3 GeneGo (Thomson Reuters) Pathways for CXCR1

	Cell adhesion ECM remodeling
	Inhibitory action of Lipoxins on Superoxide production in neutrophils
	Inhibitory action of Lipoxins on neutrophil migration

3 BioSystems Pathways for CXCR1

	GPCRs, Class A Rhodopsin-like
	GPCRs, Other
	Peptide GPCRs

5/8 Reactome Pathways for CXCR1 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

4 Kegg Pathways (Kegg details for CXCR1):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Endocytosis
	Epithelial cell signaling in Helicobacter pylori infection

CXCR1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CXCR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/197 Interacting proteins for CXCR1 (P25024³ ENSP00000295683⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 197)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL8	P10145³, ENSP00000306512⁴	I2D: score=4 STRING: ENSP00000306512
CXCR2	P25025³, ENSP00000319635⁴	I2D: score=3 STRING: ENSP00000319635
GNA15	P30679³, ENSP00000262958⁴	I2D: score=2 STRING: ENSP00000262958
ADRA1A	P35348³, ENSP00000369960⁴	I2D: score=1 STRING: ENSP00000369960
GNA14	O95837³, ENSP00000365807⁴	I2D: score=1 STRING: ENSP00000365807

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002407	dendritic cell chemotaxis	TAS	16621978
GO:0006935	chemotaxis	TAS	10725748
GO:0006954	inflammatory response	TAS	10725748
GO:0007166	cell surface receptor signaling pathway	IDA	10734056
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8381837

CXCR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CXCR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for CXCR1

Compounds for CXCR1 available from Tocris Bioscience About this table

Compound	Action	CAS #
SB 265610	Potent CXCR2 antagonist	[211096-49-0]
SB 225002	Potent and selective CXCR2 antagonist	[182498-32-4]

1 HMDB Compound for CXCR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for CXCR1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Ketoprofen	--	22071-15-4	target	other	15974585 11331079 9093816

10/36 Novoseek chemical compound relationships for CXCR1 gene (see all 36) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
groalpha	88.1	14	9195914 (2), 10188995 (2), 15561756 (2), 15476666 (1) (see all 10)
grogamma	80.7	2	20044480 (1), 11808935 (1)
rantes	76.2	19	1699135 (2), 11776150 (2), 7515718 (1), 7642634 (1) (see all 16)
grobeta	74.2	2	20044480 (1), 11808935 (1)
fmlp	65.8	18	8699129 (3), 9553132 (2), 9933081 (1), 9013980 (1) (see all 11)
leukotriene b4	50	2	11994504 (1), 10233431 (1)
calcium	47.6	32	8903513 (3), 1379593 (2), 10188995 (2), 10206993 (2) (see all 23)
tarc	40.7	1	19538461 (1)
phosphoinositide	37	1	12594210 (1)
phycoerythrin	27.6	3	15008605 (1), 7706709 (1)

Search CenterWatch for drugs/clinical trials and news about CXCR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CXCR1 gene:

NM_000634.2

Unigene Cluster for CXCR1:

Chemokine (C-X-C motif) receptor 1

Hs.194778 [show with all ESTs]

Unigene Representative Sequence: NM_000634

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000295683(uc002vhc.3)

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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCR1:
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCR1

Additional cDNA sequence:

AK298647.1 AK309632.1 AK312668.1 BC028221.1 BC072397.1 CR541994.1 CR542029.1 L19591.1

M68932.1 U11871.1

1 DOTS entry:

DT.208250

16 AceView cDNA sequences:

U11871 CR617846 CA425329 NM_000634 CR541994 BF001579 M68932 AU100346

L19591 CR542029 BC028221 BC072397 BM922807 AL531903 BX431796 AL564211

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CXCR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAGCCACC

About this image

CXCR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Bone marrow-derived mesenchymal stem cells (Stempeucel) (Adult Stem / Progenitor Cell)

Bone

Line H1 (WA01) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CXCR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXCR1

SOURCE GeneReport for Unigene cluster: Hs.194778

SABiosciences Expression via Pathway-Focused PCR Arrays including CXCR1 (see all 6):

G Protein Coupled Receptors 384HT in human mouse rat

Antigen Presenting Cells in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CXCR1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	--	55(a) 54(a)	many ↔ many many ↔ many	1(88971792-88972871) 1(88981687-88982766)
African clawed frog (Xenopus laevis)	Amphibia	CXCR2²	CXCR2 like protein	76.43(n)		AJ312936.1
zebrafish (Danio rerio)	Actinopterygii	CU855890.2⁶ CU855890.1⁶	--	43(a) 36(a)	many ↔ many many ↔ many	9(49095701-49096732) 9(49072980-49076657)

ENSEMBL Gene Tree for CXCR1 (if available)
TreeFam Gene Tree for CXCR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CXCR1 gene

CCR6² CCR5² CXCR6² CXCR3² XCR1² CCR9² CCBP2² CCRL2²

CCR7² CX3CR1² CCR8² CXCR2² CCRL1² CCR4² CCR1² CCR2²

CXCR5² CCR10² CCR3² CXCR4²

18/58 SIMAP similar genes for CXCR1 using alignment to 1 protein entry: CXCR1_HUMAN(see all similar genes):

IL8RB CXCR2 CCR6 CCR7 CCR2 BDKRB1

CCR4 CXCR4 CCR5 CCBP2 CCR9 CX3CR1

AGTR1 BLR1 CCR1 CXCR3 CXCR5 CXCR6

CXCR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3092969^1,2	C,F,H,	--	210880306(-)	`ATGAAT/CGCATG`	1	--	ds500¹		24		NA NS MN EA CSA WA	2026
rs2854385^1,2	C,H	--	210880373(-)	`GGTTTA/GTTCAC`	1	--	ut3¹ ese³		9		MN NS EA	820
rs17838610^1,2	C,F,H,	--	210880456(-)	`CTCACC/AAGTCC`	1	--	ut3¹ ese³		14		NS NA MN CSA WA	1534
rs3092970^1,2	C,F,H,	--	210880531(-)	`AGCTTC/AACCCT`	1	--	ut3¹ ese³		12		NA NS EA WA	1342
rs2854384^1,2	H	--	210880554(-)	`GAAATG/CCTCCT`	1	--	ut3¹		4		NS EA	416
rs16858794^1,2	C,F,H,	--	210880776(-)	`TGGAAG/TTATCT`	1	--	ut3¹ ese³		14		NS NA WA	1644
rs55706819^1,2	C,	--	210880866(+)	`GGATGA/CTGATG`	1	--	ut3¹		0	--	--	--	--
rs3092971^1,2	C,F,H,	--	210880877(-)	`CTGGCG/ATGCAG`	1	--	ut3¹ ese³		8		NA NS EA WA	622
rs41451552^1,2	C,	--	210881180(-)	`TGATCC/GGAGCT`	1	--	ut3¹		1		NA	48
rs16858798^1,2	C,F,H,	--	210881218(-)	`TAAGCG/ATTGAG`	1	--	ut3¹		10		NS EA NA WA	1172

HapMap Linkage Disequilibrium report for CXCR1 (219027568 - 219031718 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CXCR1: --
Human Gene Mutation Database (HGMD): CXCR1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCR1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CXCR1 for disorders           About GeneDecksing

OMIM gene information: 146929
OMIM disorders: 609423
20/99 diseases for CXCR1 (see all 99):    About MalaCards

chronic nk-cell lymphocytosis hyper-ige syndrome aids, slow progression to aggressive nk cell leukemia

mycosis fungoides pulmonary alveolar proteinosis denture stomatitis urinary tract infection

temporal lobe epilepsy gastroesophageal reflux disease allergic rhinitis acute pyelonephritis

anterior uveitis gastric cardia adenocarcinoma pyelonephritis cystic fibrosis

squamous cell carcinoma chronic obstructive pulmonary disease biliary tract cancer burkitt's lymphoma

2 diseases from the University of Copenhagen DISEASES database for CXCR1:

Pyelonephritis Chronic NK-cell lymphocytosis

10/63 Novoseek disease relationships for CXCR1 gene (see all 63) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	59.6	20	16982101 (2), 8947914 (1), 10623425 (1), 10688807 (1) (see all 18)
melanoma	45.2	47	14713106 (6), 19401689 (5), 19585580 (5), 19683430 (3) (see all 17)
urinary tract infection recurrent	43.1	5	16339057 (3), 17942281 (1)
acute pyelonephritis	41.1	4	17786197 (1), 11404374 (1), 16339057 (1)
leukemia basophilic	39	2	15896307 (1)
necrosis	33.3	17	10090924 (2), 10454826 (1), 15451491 (1), 10556424 (1) (see all 12)
tumors	26.9	35	9568059 (2), 19585580 (2), 16393674 (2), 10090924 (2) (see all 25)
pulmonary disease chronic obstructive	23.2	4	15772681 (2), 12857718 (1), 15637552 (1)
b-all	22.5	1	16118018 (1)
psoriasis	20.4	6	9424095 (2), 1361277 (2), 10653603 (1), 12823305 (1)

Human Genome Epidemiology (HuGE) Navigator: CXCR1 (50 documents)

Export disorders for CXCR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CXCR1 gene, integrated from 9 sources (see all 503):
(articles sorted by number of sources associating them with CXCR1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils. (PubMed id 16205979)^{1, 2, 9} Liu Y.... Su B. (2005)
Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PubMed id 11196695)^{1, 2, 9} Kato H.... Tokunaga K. (2000)
Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2 q35. (PubMed id 1427896)^{1, 3, 9} Morris S.W....Cerretti D.P. (1992)
Characterization of two high affinity human interleukin-8 receptors. (PubMed id 1379593)^{1, 2, 9} Lee J.... Wood W.I. (1992)
Structure of a CXC chemokine-receptor fragment in complex with interleukin-8. (PubMed id 10368283)^{1, 2, 9} Skelton N.J.... Lowman H. (1999)
Structure and functional expression of a human interleukin-8 receptor. (PubMed id 1840701)^{1, 2, 9} Holmes W.E.... Wood W.I. (1991)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. (PubMed id 7929358)^{1, 2} Ahuja S.K.... Murphy P.M. (1994)
Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2. (PubMed id 8384312)^{1, 2} Cerretti D.P....Beckmann M.P. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3577	HGNC: 6026	AceView: IL8RA	Ensembl:ENSG00000163464	euGenes: HUgn3577
ECgene: CXCR1	Kegg: 3577	H-InvDB: CXCR1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CXCR1	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CXC_chemokine_receptors
SeattleSNPs	http://pga.gs.washington.edu/data/il8ra/

Intellectual Property for CXCR1 gene
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Patent Information for CXCR1 gene:
Search GeneIP for patents involving CXCR1

GeneCards and IP:
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CXCR1 Gene

chemokine (C-X-C motif) receptor 1

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CXCR1 (Gene Symbol)
Chemokine (C-X-C Motif) Receptor 1
IL8RA
CDw128a
CMKAR1
CD181
CKR-1
Interleukin 8 Receptor, Alpha
High Affinity Interleukin-8 Receptor A
CXC-R1
CXCR-1
IL-8 Receptor Type 1
IL-8R A
C-C
C-C-CKR-1
CD128
IL8R1
IL8RBA
C-X-C Chemokine Receptor Type 1
Interleukin-8 Receptor Type 1
Interleukin-8 Receptor Type A
CD181 Antigen

URINARY TRACT INFECTION RECURRENT
Melanoma
Tuberculosis Pulmonary
sepsis
Glioma
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Endometriosis
LEUKEMIA BASOPHILIC
Cystic Fibrosis
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B-ALL
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Osteoarthritis
ACUTE LEUKEMIA
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effusion
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OVARIAN CARCINOMA
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Psoriasis
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FIBROSIS IDIOPATHIC PULMONARY
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CXCR1 Gene

chemokine (C-X-C motif) receptor 1

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