CXCL9 Gene
protein-coding GIFtS : 57
GCID: GC04 M076922
chemokine (C-X-C motif) ligand 9 (Previous name: monokine induced by gamma interferon ) (Previous symbols: CMK, MIG )
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Aliasesfor CXCL9 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chemokine (C-X-C Motif) Ligand 9 1 2 Monokine Induced By Gamma Interferon1 2 MIG1 2 3 5 Gamma-Interferon-Induced Monokine2 3 SCYB91 2 3 5 Monokine Induced By Interferon-Gamma2 3 CMK1 2 3 Small-Inducible Cytokine B92 3 Humig1 2 C-X-C Motif Chemokine 92 Crg-101 HuMIG3
Export aliases for CXCL9 gene to outside databases Previous GC identifers: GC04M076818 GC04M077112 GC04M077315 GC04M077380 GC04M077279 GC04M072674
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Summariesfor CXCL9 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CXCL9 : The function of this gene has not been specifically defined; however, it is thought to be involved in T cell trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of cytokines. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325 Function : Cytokine that affects the growth, movement, or activation state of cells that participate in immune andinflammatory response. Chemotactic for activated T-cells. Binds to CXCR3 Gene Wiki entry for CXCL9
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Genomic Viewsfor CXCL9 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CXCL9 gene promoter: IRF-2 p53 AML1a STAT3 IRF-1 Other transcription factors Search SABiosciences Chromatin IP Primers for CXCL9 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL9
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q21.1 HGNC cytogenetic band: 4q21 CXCL9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M076922: view genomic region
(about GC identifiers )
Start:
76,922,428 bp from pter
End:
76,928,641 bp from pter
Size:
6,214 bases
Orientation:
minus strand
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Proteinsfor CXCL9 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325 (See
protein sequence )Recommended Name: C-X-C motif chemokine 9 precursor Size : 125 amino acids; 14019 Da
Subcellular location : Secreted
Secondary accessions : Q503B4Explore the universe of human proteins at neXtProt for CXCL9: NX_Q07325 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q07325 CXCL9 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_002407.1 ENSEMBL proteins: ENSP00000354901 Reactome Protein details: Q07325 Human Recombinant Protein Products for CXCL9: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
TAS -- GO:0005615 extracellular space
IEA -- GO:0009897 external side of plasma membrane
IEA --
CXCL9 for ontologies About GeneDecksing CXCL9 Antibody Products: Assay Products for CXCL9:
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Protein
Domains / Familiesfor CXCL9 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CXCL9 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q07325 ProtoNet protein and cluster: Q07325
UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325 Similarity : Belongs to the intercrine alpha (chemokine CxC) family
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Functionfor CXCL9 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: CXCL9_HUMAN, Q07325 Function : Cytokine that affects the growth, movement, or activation state of cells that participate in immune andinflammatory response. Chemotactic for activated T-cells. Binds to CXCR3 Induction : By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
CXCL9 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for CXCL9 : 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cxcl9) :
CXCL9 for phenotypes About GeneDecksing Animal Models: Mouse knock-out Cxcl9 tm1Jmf for CXCL9Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CXCL9 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CXCL9OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416 ) Sino Biological Human cDNA Clone for CXCL9 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXCL9 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CXCL9
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9
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Pathways & Interactionsfor CXCL9 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/13 super-pathways (see all 13 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 PEDF Induced Signaling 2 Class A/1 (Rhodopsin-like receptors) 3 Rho Family GTPases 4 Signaling by GPCR 5 PAK Pathway
Pathway sources See GeneCards unified pathways Show all pathways 5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL9 (see all 17 )4 BioSystems Pathways for CXCL9 5/8
Reactome Pathways for CXCL9 (see all 8 )3
Kegg Pathways (Kegg details for CXCL9) :
CXCL9 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL9 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/165 Interacting proteins for CXCL9 (Q07325 2 , 3 ENSP00000354901 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 165 )About this table Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9 ): About this table
CXCL9 for ontologies About GeneDecksing
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Drugs & Compoundsfor CXCL9 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
CXCL9 for compounds About GeneDecksing Browse Tocris compounds for CXCL9 10/25 Novoseek chemical compound relationships for CXCL9 gene (see all 25 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
rantes
85.6
85
17489976 (5), 9856808 (3), 12164740 (3), 12864798 (3) (see all 59 )
tarc
84.5
31
11310827 (3), 11920617 (3), 15927812 (3), 16583210 (3) (see all 18 )
ccl3
81.1
26
17170049 (3), 12960247 (2), 19293190 (1), 19906920 (1) (see all 20 )
ena 78
80.3
1
17444857 (1)
groalpha
67.8
7
15975968 (3), 19597126 (1), 9846975 (1), 11422029 (1)
ccl4
56.5
19
12960247 (2), 11178128 (1), 19265171 (1), 15591886 (1) (see all 14 )
sdf 1
46
1
17384278 (1)
ifn-alpha
43.3
3
16736505 (1), 16571725 (1)
il 10
36.5
3
15975968 (2), 19340290 (1)
vegf
10.9
11
18644076 (4), 19160404 (1), 17459161 (1), 19010327 (1) (see all 6 )
Search CenterWatch for drugs/clinical trials and news about CXCL9
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Transcriptsfor CXCL9 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CXCL9 gene: NM_002416.1 Unigene Cluster for CXCL9:
Chemokine (C-X-C motif) ligand 9 Hs.77367 [show with all ESTs ] Unigene Representative Sequence: BC042178 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000264888 (uc003hjh.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CXCL9 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CXCL9OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CXCL9 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CXCL9
Additional cDNA sequence: AK311852.1 BC025745.1 BC042178.1 BC063122.1 BC095396.1 X72755.1
4 DOTS entries : DT.414759 DT.99955548
DT.95168680 DT.95168681 24/95 AceView cDNA sequences (see all 95 ):
AA131406 BC042178 T89439 AI784420 X72755 AI918026 AA974879 NM_002416 AI686870 AI924853 AI370217 AA970872 AA131506 BQ016361 T29117 AI433482 BC063122 CB961971 CD110190 BM855361 AA948337 AA361362 AI281492 AA115269 GeneLoc Exon Structure
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Expression for CXCL9 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CXCL9 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image CXCL9 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See CXCL9 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CXCL9 SOURCE GeneReport for Unigene cluster: Hs.77367 SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL9 (see all 13 ): Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CXCL9Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CXCL9 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CXCL9 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CXCL9 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9
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Orthologsfor CXCL9 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CXCL9 gene from 1/7 species (see all 7 ) About this table
ENSEMBL Gene Tree for CXCL9 (if available)TreeFam Gene Tree for CXCL9 (if available)
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Paralogsfor CXCL9 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CXCL9 gene CXCL10 2 8 SIMAP similar genes for CXCL9 using alignment to 2 protein entries: CXCL9_HUMAN (see all proteins ):PPBP CXCL3 CXCL2 CXCL1 CXCL10 CXCL11 CXCL5 CXCL6
CXCL9 for paralogs About GeneDecksing
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Genomic Variantsfor CXCL9 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 4 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CXCL9 (76922428 - 76928641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CXCL9: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CXCL9
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Disorders
/ Diseasesfor CXCL9 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CXCL9 for disorders About GeneDecksing
OMIM gene information: 601704
OMIM disorders : --20/115 diseases for CXCL9 (see all 115 ): About MalaCards inclusion body myositis lymphomatoid granulomatosis hypersensitivity reaction type ii disease complex regional pain syndrome sydenham's chorea chronic inflammatory demyelinating polyneuropathy mycosis fungoides demyelinating polyneuropathy graft versus host disease lichen planus proliferative glomerulonephritis vernal keratoconjunctivitis eosinophilic pneumonia erythema multiforme severe acute respiratory syndrome melioidosis alopecia areata chronic eosinophilic pneumonia spotted fever visceral leishmaniasis 2 diseases from the University of Copenhagen DISEASES database for CXCL9 :Lung disease Skin disease 10/59 Novoseek disease relationships for CXCL9 gene (see all 59 ) About this table
Human Genome Epidemiology (HuGE) Navigator: CXCL9 (11 documents) Export disorders for CXCL9 gene to outside databases
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Publicationsfor CXCL9 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CXCL9 gene, integrated from 9 sources (see all 434 ) (see top 10 ): (articles sorted by number of sources associating them with CXCL9) Utopia : connect your pdf to the dynamic world of online information
HuMig: a new human member of the chemokine family of cytokines. (PubMed id 8476424) 1 , 2 , 3 Farber J.M. (1993) Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762) 1 , 2 , 9 Tensen C.P.... Willemze R. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10). (PubMed id 9730616) 1 , 3 Erdel M....Werner-Felmayer G. (1998) Involvement of the interferon-gamma-induced T cell-attracting chemokines, interferon-gamma-inducible 10-kd protein (CXCL10) and monokine induced by interferon-gamma (CXCL9), in the salivary gland lesions of patients with Sjogren's syndrome. (PubMed id 12384933) 1 , 9 Ogawa N....Sugai S. (2002) Detection of interferon-gamma-inducible chemokines in human milk. (PubMed id 12856973) 1 , 9 Takahata Y....Hara T. (2003) Constitutive nuclear factor kappaB activity is required to elicit interferon-gamma-induced expression of chemokine CXC ligand 9 (CXCL9) and CXCL10 in human tumour cell lines. (PubMed id 12946268) 1 , 9 Hiroi M. and Ohmori Y. (2003) Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. (PubMed id 19344719) 1 , 9 Wasmuth H.E....Trautwein C. (2009) ESAT6-induced IFNgamma and CXCL9 can differentiate severity of tuberculosis. (PubMed id 19340290) 1 , 9 Hasan Z....Hussain R. (2009) VAP-1, Eotaxin3 and MIG as potential atherosclerotic triggers of severe calcified and stenotic human aortic valves: effects of statins. (PubMed id 17490641) 1 , 9 Anger T....Garlichs C.D. (2007) Human Mig chemokine: biochemical and functional characterization. (PubMed id 7595201) 1 , 9 Liao F....Farber J.M. (1995) Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathy. (PubMed id 18413205) 1 , 9 Higurashi M....Yamada K. (2009) Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives. (PubMed id 16243485) 1 , 9 Chuang Y.H....Gershwin M.E. (2005) The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells. (PubMed id 11422029) 1 , 9 Stoof T.J....Boorsma D.M. (2001) Close resemblance between chemokine receptor expression profiles of lymphoproliferative disease of granular lymphocytes and their normal counterparts in association with elevated serum concentrations of IP-10 and MIG. (PubMed id 17875534) 1 , 9 Momose K....Ishida F. 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(PubMed id 17922833) 9 Kulka M....Schleimer R.P. (2008) Upregulation of chemokine expression in murine cornea due to mechanical trauma or endotoxin. (PubMed id 17993576) 9 Pillai R.G....George A.J. (2008) Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors. (PubMed id 18270317) 9 Verzijl D....Leurs R. (2008) Detection of clinically relevant levels of protein an alyte under physiologic buffer using planar field effect transistors. (PubMed id 18632260) 9 Gupta S....Lee S.C. (2008) CD4+ T cells transfer resistance against Citrobacter rodentium-induced infectious colitis by induction of Th 1 immunity. (PubMed id 18261038) 9 Spahn T.W....Kucharzik T. (2008) Fimbrial lectins influence the chemokine repertoire in the urinary tract mucosa. (PubMed id 17228365) 9 Godaly G....Svanborg C. (2007) Dynamic alteration of soluble serum biomarkers in healthy aging. (PubMed id 17689975) 9 Shurin G.V....Lokshin A.E. (2007) IP-10 is an early diagnostic marker for identification of late-onset bacterial infection in preterm infants. (PubMed id 17211148) 9 Ng P.C....Fok T.F. (2007) High T-helper-1 cytokines but low T-helper-3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes. (PubMed id 17315139) 9 Stechova K....FaresjAP M. (2007) The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells. (PubMed id 17947699) 9 Tudhope S.J....Donnelly L.E. (2007) Tolerogenic dendritic cells pulsed with enterobacterial extract suppress development of colitis in the severe combined immunodeficiency transfer model. (PubMed id 17428312) 9 Pedersen A.E....Claesson M.H. (2007) Increased serum levels of CXCL8 chemokine in acute toxoplasmic retinochoroiditis. (PubMed id 17488320) 9 Goncalves R.M....Teixeira A.L. (2007) Expression of interferon-gamma- inducible protein-10 and its receptor CXCR3 in chronic pancreatitis. (PubMed id 17912012) 9 Singh L....Wig J.D. (2007) Stimulation of purinergic receptors modulates chemokine expression in human keratinocytes. (PubMed id 17039239) 9 Pastore S....Ferrari D. (2007) Up-regulation of CXC chemokines and their receptors: implications for proinflammatory microenvironments of ovarian carcinomas and endometriosis. (PubMed id 17707463) 9 Furuya M....Kimura S. (2007) Genes regulated by interferon-gamma in human uterine microvascular endothelial cells. (PubMed id 17912462) 9 Kitaya K....Honjo H. (2007) High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis. (PubMed id 17393419) 9 Shin J.J....Steere A.C. (2007) Simultaneous detections of 27 cytokines during cerebral wound healing by multiplexed bead-based immunoassay for wound age estimation. (PubMed id 18159995) 9 Takamiya M....Aoki Y. (2007) Laminar flow attenuates interferon-induced inflammatory responses in endothelial cells. (PubMed id 17383622) 9 Tsai Y.C....Wang D.L. (2007) Diminished inflammatory responses to natural pneumovirus infection among older mice. (PubMed id 17655904) 9 Bonville C.A....Domachowske J.B. (2007) Chemokines and chemokine receptors in multiple sclerosis. Potential targets for new therapies. (PubMed id 17295707) 9 SzczuciA8ski A. and Losy J. (2007) Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis. (PubMed id 17302897) 9 Corvino C.L....Blotta M.H. (2007) Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha. (PubMed id 17878383) 9 Liu L.Y....Kelly E.A. (2007) Early posttransplant inflammation promotes the development of alloimmunity and chronic human lung allograft rejection. (PubMed id 17264811) 9 Bharat A....Mohanakumar T. (2007) Role of chemokines in endocrine autoimmune diseases. (PubMed id 17475924) 9 Rotondi M....Romagnani P. (2007) Serum chemokine profile in patients with bullous pemphigoid. (PubMed id 17300233) 9 Nakashima H....Tamaki K. (2007) CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity. (PubMed id 17640964) 9 Freeman C.M....Chensue S.W. (2007) Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy. (PubMed id 17425653) 9 Wong C.K....Lam C.W. (2007) Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis. (PubMed id 17459161) 9 Ingram J.L....Bonner J.C. (2007) Characterization of the divergent wound-healing responses occurring in the pathergy reaction and normal healthy volunteers. (PubMed id 17056573) 9 Melikoglu M....Oliver S. (2006) Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies. (PubMed id 16736505) 9 Hua J....Crow M.K. (2006) Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. (PubMed id 16885372) 9 Walser T.C....Fulton A.M. (2006) CXC receptor and chemokine expression in human meningioma: SDF1/CXCR4 signaling activates ERK1/2 and stimulates meningioma cell proliferation. (PubMed id 17384278) 9 Barbieri F....Florio T. (2006) Interleukin-7 induced immunopathology in arthritis. (PubMed id 17038478) 9 Hartgring S.A....van Roon J.A. (2006) [Assessment of a microarray of solid-phase antibodies to the study of chemokines secreted by the chorioamniotic membrane] (PubMed id 17539322) 9 Gomez Lopez N.Y....Vadillo Ortega F. (2006) Cycloxygenase-2 inhibition augments the efficacy of a cancer vaccine. (PubMed id 16397045) 9 Haas A.R....Albelda S.M. (2006) Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses. (PubMed id 16574937) 9 Gauvreau G.M....O'Byrne P.M. (2006) Gene transfer for the treatment of neovascular ocular disease (an American Ophthalmological Society thesis). (PubMed id 17471360) 9 Stout J.T. (2006) The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 response. (PubMed id 17015796) 9 van Loosdregt J....de Weger R.A. (2006) Cytokine assay of the epidural space lavage in patients with lumbar intervertebral disk herniation and radiculopathy. (PubMed id 16778661) 9 Scuderi G.J....Hallab N. (2006) Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation. (PubMed id 16571725) 9 Ho H.H. and Ivashkiv L.B. (2006) Different angiogenic activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis. (PubMed id 17035428) 9 Antoniou K.M....Siafakas N.M. (2006) Flow-cytometric analysis of cytokine production in human paracoccidioidomycosis. (PubMed id 17045486) 9 Mamoni R.L. and Blotta M.H. (2006) Human cytomegalovirus immediate-early 2 protein IE86 blocks virus-induced chemokine expression. (PubMed id 16378994) 9 Taylor R.T. and Bresnahan W.A. (2006) Expression of chemokines and chemokine receptors in cutaneous CD30+ lymphoproliferative disorders. (PubMed id 16634894) 9 Yamaguchi T....Kikuchi M. (2006) Preferential type 1 chemokine receptors and cytokine production of CD28- T cells in ankylosing spondylitis. (PubMed id 16219708) 9 Duftner C....Schirmer M. (2006) Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11. (PubMed id 16368892) 9 Dagan-Berger M....Peled A. (2006) Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNbeta-responsive genes in peripheral blood lymphocytes in vitro: an implication for IFNbeta-related adverse effects in multiple sclerosis. (PubMed id 16709257) 9 Satoh J....Yamamura T. (2006) Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (PubMed id 16767372) 9 Shoji J....Sawa M. (2006) Aberrant expression of CC and CXC chemokines and their receptors in patients with asthma. (PubMed id 16602032) 9 Lun S.W....Lam C.W. (2006) Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1. (PubMed id 16864900) 9 Heijmans-Antonissen C....Zijlstra F.J. (2006) Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. (PubMed id 17052299) 9 Chien J.Y....Yang P.C. (2006) CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production. (PubMed id 16337473) 9 Romagnani P....Annunziato F. (2005) NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells. (PubMed id 15536145) 9 Saudemont A....Quesnel B. (2005) Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough. (PubMed id 15805991) 9 Hartl D....Krauss-Etschmann S. (2005) Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection. (PubMed id 15661146) 9 Bieche I....Vidaud M. (2005) CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II. (PubMed id 16033640) 9 Pechkovsky D.V....Zissel G. (2005) Gene expression profile in the muscles of patients with inflammatory myopathies: effect of therapy with IVIg and biological validation of clinically relevant genes. (PubMed id 15857930) 9 Raju R. and Dalakas M.C. (2005) Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway. (PubMed id 15586367) 9 Di Carlo E....Triebel F. (2005) Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. (PubMed id 16195357) 9 Tang N.L....Lam C.W. (2005) Analysis of the biliary transcriptome in experimental biliary atresia. (PubMed id 16083724) 9 Carvalho E....Bezerra J.A. (2005) The production of CXCR3-agonistic chemokines by synovial fibroblasts from patients with rheumatoid arthritis. (PubMed id 15004722) 9 Ueno A....Makino H. (2005) L-Arginine modulates CXC chemokines in the human intestinal epithelial cell line HCT-8 by the NO pathway. (PubMed id 16040184) 9 Marion R....DAcchelotte P. (2005) The CXCR3 targeting chemokine CXCL11 has potent antitumor activity in vivo involving attraction of CD8+ T lymphocytes but not inhibition of angiogenesis. (PubMed id 16000952) 9 Hensbergen P.J....Tensen C.P. (2005) Alpha-chemokine receptors CXCR1-3 and their ligands in idiopathic inflammatory myopathies. (PubMed id 15937690) 9 De Paepe B....De Bleecker J.L. (2005) Acute and long-term alteration of chemokine mRNA expression after anti-viral and anti-inflammatory treatment in herpes simplex virus encephalitis. (PubMed id 15663962) 9 Sellner J....Meyding-LamadA" U. (2005) Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3. (PubMed id 15789559) 9 Ondeykal J.G....Singh S.B. (2005) Polarized helper T cells in tubercular pleural effusion: phenotypic identity and selective recruitment. (PubMed id 16025563) 9 Mitra D.K....Ghosh B. (2005) Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-beta. (PubMed id 15178706) 9 Eriksson M....Sentman C.L. (2004) Activation of cytokines and NF-kappa B in corneal epithelial cells infected by respiratory syncytial virus: potential relevance in ocular inflammation and respiratory infection. (PubMed id 15256003) 9 Bitko V....Barik S. (2004) CpG oligodeoxynucleotides directly induce CXCR3 chemokines in human B cells. (PubMed id 15249208) 9 Kato A....Matsumoto K. (2004) Description of B lymphocytes and plasma cells, complement, and chemokines/receptors in acute liver allograft rejection. (PubMed id 15257040) 9 Krukemeyer M.G....Krenn V. (2004) Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction. (PubMed id 14961998) 9 Hu H....Knechtle S.J. (2004) NMR structure of CXCR3 binding chemokine CXCL11 (ITAC). (PubMed id 15273303) 9 Booth V.... Sykes B.D. (2004) CXCR3-binding chemokines in multiple myeloma. (PubMed id 15072832) 9 Pellegrino A....Dammacco F. (2004) IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. (PubMed id 15128840) 9 Sharif M.N....Ivashkiv L.B. (2004) Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA. (PubMed id 15208597) 9 Simons F.E....HayGlass K.T. (2004) MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. (PubMed id 14517275) 9 Shi S....Ehrt S. (2003) Chemokine and receptor-gene expression during early and late acute rejection episodes in human cardiac allografts. (PubMed id 12829909) 9 Fahmy N.M....Fairchild R.L. (2003) High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis. (PubMed id 12932287) 9 Ruschpler P....Stiehl P. (2003) Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation. (PubMed id 14515277) 9 Xanthou G....Pease J.E. (2003) IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice. (PubMed id 12627325) 9 Cardozo A.K....Eizirik D.L. (2003) Re-evaluation of fibrogenic cytokines in lung fibrosis. (PubMed id 12570673) 9 Kelly M....Gauldie J. (2003) High expression of chemokines Gro-alpha (CXCL-1), IL-8 (CXCL-8), and MCP-1 (CCL-2) in inflamed human corneas in vivo. (PubMed id 12796254) 9 Spandau U.H....Kruse F.E. (2003) Cytokine- and chemokine-based gene therapy for cancer. (PubMed id 14601514) 9 Chada S....Mhashilkar A.M. (2003) Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes. (PubMed id 12555204) 9 Guillemin G.J....Brew B.J. (2003) Quinolinic acid up-regulates chemokine production and chemokine receptor expression in astrocytes. (PubMed id 15206714) 9 Croitoru-Lamoury J....Brew B.J. (2003) Recruitment of lymphocytes to the human liver. (PubMed id 11869363) 9 Lalor P.F....Adams D.H. (2002) [Chemokines and tumors] (PubMed id 12489485) 9 Pellegrino A....Dammacco F. (2002) Peripheral blood cell-specific cytokines in persons with untreated HIV infection in Malawi, Africa. (PubMed id 12487808) 9 Chatt J.A....Jarvis W.R. (2002) Cytokine and adhesion molecule expression in primary human endothelial cells stimulated with fever-range hyperthermia. (PubMed id 12537753) 9 Shah A....Evans S.S. (2002) Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis. (PubMed id 11564831) 9 Liu M.T....Lane T.E. (2001) Prevalence of CD8(+)alpha beta T cells in Trypanosoma cruzi-elicited myocarditis is associated with acquisition of CD62L(Low)LFA-1(High)VLA-4(High) activation phenotype and expression of IFN-gamma-inducible adhesion and chemoattractant molecules. (PubMed id 11580984) 9 dos Santos P.V....Lannes-Vieira J. (2001) Chemokine gene expression and clonal analysis of B cells in tissues involved by lymphoid interstitial pneumonitis from HIV-infected pediatric patients. (PubMed id 11598160) 9 Teruya-Feldstein J....Jaffe E.S. (2001) Chemokines, chemokine receptors and allergy. (PubMed id 11340325) 9 Kaplan A.P. (2001) Differential and sequential expression of multiple chemokines during elicitation of allergic contact hypersensitivity. (PubMed id 11159181) 9 Goebeler M....Gillitzer R. (2001) CXCR3 internalization following T cell-endothelial cell contact: preferential role of IFN-inducible T cell alpha chemoattractant (CXCL11). (PubMed id 11739530) 9 Sauty A....Luster A.D. (2001) Induction of multiple chemokine and colony-stimulating factor genes in experimental Burkholderia pseudomallei infection. (PubMed id 11564157) 9 Barnes J.L....Hirst R.G. (2001) Expression of functional chemokine receptors CXCR3 and CXCR4 on human melanoma cells. (PubMed id 11571298) 9 Robledo M.M....TeixidA^ J. (2001) The T-cell chemokine receptor CXCR3 is expressed highly in low-grade mycosis fungoides. (PubMed id 11242798) 9 Lu D....Jones D. (2001) The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8). (PubMed id 11178128) 9 Kraan M.C....Tak P.P. (2001) Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection. (PubMed id 11714650) 9 Melter M....Briscoe D.M. (2001) Activation of human peripheral blood mononuclear cell s by nonpathogenic bacteria in vitro: evidence of NK cells as primary targets. (PubMed id 10639443) 9 Haller D....Schiffrin E.J. (2000) Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cells. (PubMed id 11023990) 9 Salcedo R....Oppenheim J.J. (2000) Requirement of the chemokine receptor CXCR3 for acute allograft rejection. (PubMed id 11085753) 9 Hancock W.W....Gerard C. (2000) Cytokines and soluble cytokine receptor induction after IL-12 administration in cancer patients. (PubMed id 10606961) 9 Haicheur N....Tartour E. (2000) [Role of chemokines in human skin wound healing] (PubMed id 10929648) 9 Gillitzer R....Voss A. (2000) Histamine and histamine-receptor antagonists modify gene expression and biosynthesis of interferon gamma in peripheral human blood mononuclear cells and in CD19-depleted cell subsets. (PubMed id 10569698) 9 Horvath B.V....Falus A. (1999) Strong expression of the lymphoattractant C-X-C chemokine Mig is associated with heavy infiltration of T cells in human malignant melanoma. (PubMed id 10629557) 9 Kunz M....Gillitzer R. (1999) Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors. (PubMed id 10372118) 9 Broxmeyer H.E....Pelus L.M. (1999) Role for interactions between IP-10/Mig and CXCR3 in proliferative glomerulonephritis. (PubMed id 10589690) 9 Romagnani P....Serio M. (1999) The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. (PubMed id 9466968) 9 Qin S....Mackay C.R. (1998) Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. (PubMed id 9670053) 9 Geras-Raaka E....Gershengorn M.C. (1998) Chemokines IL-8, GROalpha, MCP-1, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing. (PubMed id 9846975) 9 Engelhardt E....Gillitzer R. (1998) Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids. (PubMed id 9465307) 9 Modi W.S. and Chen Z.Q. (1998) Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. (PubMed id 9500790) 9 Sallusto F....Lanzavecchia A. (1998) Detection, cDNA cloning and sequencing of canine interleukin 12. (PubMed id 9617567) 9 BA1ttner M....Kaaden O.R. (1998) A 70-kilodalton recombinant heat shock protein of Candida albicans is highly immunogenic and enhances systemic murine candidiasis. (PubMed id 9573102) 9 Bromuro C....Cassone A. (1998) Dose distribution of low-dose subcutaneous recombinant interleukin-2 affects the secondary release of interferon-gamma in vivo. (PubMed id 10851461) 9 Meffert M....Atzpodien J. (1997) Borrelia burgdorferi activates nuclear factor-kappa B and is a potent inducer of chemokine and adhesion molecule gene expression in endothelial cells and fibroblasts. (PubMed id 9120285) 9 Ebnet K....Shaw S. (1997) Decreased interleukin-15 from activated cord versus adult peripheral blood mononuclear cells and the effect of interleukin-15 in upregulating antitumor immune activity and cytokine production in cord blood. (PubMed id 9376592) 9 Qian J.X....Cairo M.S. (1997)
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About This Section Patent Information for CXCL9 gene: Search GeneIP for patents involving CXCL9 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CXCL9 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
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Browse OriGene Antibodies OriGene shRNA RFP for CXCL9 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CXCL9 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CXCL9 OriGene Protein Over-expression Lysate for CXCL9 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CXCL9 OriGene 3'-UTR Clone for CXCL9 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CXCL9 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CXCL9 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CXCL9 OriGene Custom Protein Services for CXCL9 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CXCL9 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CXCL9 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL9 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CXCL9 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CXCL9 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CXCL9
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CXCL9
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