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CXCL9 Gene

protein-coding   GIFtS: 57
GCID: GC04M076922

Chemokine (C-X-C Motif) Ligand 9

(Previous name: monokine induced by gamma interferon)
(Previous symbols: CMK, MIG)
  See CXCL9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Ligand 91 2     Monokine Induced By Interferon-Gamma2 3
MIG1 2 3 5     Small-Inducible Cytokine B92 3
CMK1 2 3     Humig2
SCYB92 3 5     C-X-C Motif Chemokine 92
Monokine Induced By Gamma Interferon1 2     crg-102
Gamma-Interferon-Induced Monokine2 3     HuMIG3

External Ids:    HGNC: 70981   Entrez Gene: 42832   Ensembl: ENSG000001387557   OMIM: 6017045   UniProtKB: Q073253   

Export aliases for CXCL9 gene to outside databases

Previous GC identifers: GC04M076818 GC04M077112 GC04M077315 GC04M077380 GC04M077279 GC04M072674


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCL9 Gene:
The function of this gene has not been specifically defined; however, it is thought to be involved in T cell
trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of
cytokines. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL9 Gene:
CXCL9 (chemokine (C-X-C motif) ligand 9) is a protein-coding gene. Diseases associated with CXCL9 include endotheliitis, and lymphomatoid granulomatosis. GO annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CXCL10.

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325
Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and
inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3

Gene Wiki entry for CXCL9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL9 gene promoter:
         IRF-2   p53   AML1a   STAT3   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL9 promoter sequence
   Search Chromatin IP Primers for CXCL9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21

CXCL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL9 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076922:  view genomic region     (about GC identifiers)

Start:
76,922,428 bp from pter      End:
76,928,641 bp from pter
Size:
6,214 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325 (See protein sequence)
Recommended Name: C-X-C motif chemokine 9 precursor  
Size: 125 amino acids; 14019 Da
Secondary accessions: Q503B4

Explore the universe of human proteins at neXtProt for CXCL9: NX_Q07325

Explore proteomics data for CXCL9 at MOPED


See CXCL9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002407.1  
ENSEMBL proteins: 
 ENSP00000354901  
Reactome Protein details: Q07325

CXCL9 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CXCL9 (CXCL9/MIG)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for CXCL9
OriGene Protein Over-expression Lysate for CXCL9
OriGene Custom MassSpec
OriGene Custom Protein Services for CXCL9
GenScript Purified and Recombinant Proteins for CXCL9
Novus Biologicals CXCL9 Proteins
Novus Biologicals CXCL9 Lysate
Sino Biological Recombinant Protein for CXCL9
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for CXCL9 

CXCL9 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CXCL9 (CXCL9/MIG)
Browse OriGene Antibodies
OriGene Custom Antibody Services for CXCL9
Novus Biologicals CXCL9 Antibodies
Abcam antibodies for CXCL9
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for CXCL9
LSBio Antibodies in human, mouse, rat for CXCL9

CXCL9 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CXCL9
R&D Systems ELISAs for CXCL9 (CXCL9/MIG)         (see all)
GenScript Custom Assay Services for CXCL9
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
eBioscience ELISAs for CXCL9:  
                    Human MIG Instant ELISA 128 tests


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

4 InterPro protein domains:
 IPR001811 Chemokine_IL8-like_dom
 IPR001089 Chemokine_CXC
 IPR018048 Chemokine_CXC_CS
 IPR027225 CXCL9

Graphical View of Domain Structure for InterPro Entry Q07325

ProtoNet protein and cluster: Q07325

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325
Similarity: Belongs to the intercrine alpha (chemokine CxC) family


Find genes that share domains with CXCL9           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CXCL9_HUMAN, Q07325
Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and
inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3
Induction: By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity TAS2115167
GO:0005515protein binding IPI18275857
GO:0008009chemokine activity IDA12782716
GO:0048248CXCR3 chemokine receptor binding IDA12782716
     
Find genes that share ontologies with CXCL9           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for CXCL9:
 Increased gamma-H2AX phosphory 

     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cxcl9):
 hematopoietic system  immune system  mortality/aging 

Find genes that share phenotypes with CXCL9           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Cxcl9tm1Jmf for CXCL9

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCL9
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCL9

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL9
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL9

miRNA
Products:
    
miRTarBase miRNAs that target CXCL9:
hsa-mir-335-5p (MIRT016944), hsa-mir-26b-5p (MIRT028888), hsa-mir-34a-5p (MIRT025283)

Block miRNA regulation of human, mouse, rat CXCL9 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate CXCL9:
hsa-miR-4316 hsa-miR-634 hsa-miR-3662 hsa-miR-103a-2* hsa-miR-4267
SwitchGear 3'UTR luciferase reporter plasmidCXCL9 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CXCL9
Predesigned siRNA for gene silencing in human, mouse, rat CXCL9

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CXCL9

Clone
Products:
     
OriGene clones in human, mouse for CXCL9 (see all 7)
OriGene ORF clones in mouse, rat for CXCL9
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416)
Sino Biological Human cDNA Clone for CXCL9
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL9
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL9

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CXCL9
Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL9 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CXCL9_HUMAN, Q07325: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytoskeleton2
nucleus2
plasma membrane2

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0009897external side of plasma membrane IEA--

Find genes that share ontologies with CXCL9           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CXCL9 About   (see all 13)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
IL-6 Pathway0.61
MIF Mediated Glucocorticoid Regulation0.94
STAT3 Pathway0.47
PEDF Induced Signaling0.73
Endothelin-1 Signaling Pathway0.46
all-trans-Retinoic Acid Signaling in Brain0.71
Cytokine-cytokine receptor interaction0.43
2Toll-like receptor signaling pathway
Toll-like receptor signaling pathway0.94
Regulation of toll-like receptor signaling pathway0.93
Toll-like receptor signaling pathway0.94
3Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine receptors bind chemokines0.81
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
4Chemokine Signaling
Chemokine signaling pathway0.33
Chemokine Signaling0.33
5Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.44


Find genes that share SuperPaths with CXCL9           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CXCL9
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL9 (see all 17)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Transendothelial Migration of Leukocytes
MIF Mediated Glucocorticoid Regulation

5 BioSystems Pathways for CXCL9
    Type II interferon signaling (IFNG)
Toll-like receptor signaling pathway
CXCR3-mediated signaling events
IL23-mediated signaling events
Regulation of toll-like receptor signaling pathway


2 Reactome Pathways for CXCL9
    Chemokine receptors bind chemokines
G alpha (i) signalling events


3 Kegg Pathways  (Kegg details for CXCL9):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Toll-like receptor signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL9 (see all 13): 
          NFKB Signaling Targets in human mouse rat
          Antiviral Response in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Multiple Sclerosis in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CXCL9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CXCL9 (Q073251, 2, 3 ENSP000003549014) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
InteractantInteraction Details
GeneCardExternal ID(s)
DPP4P274871, 2, 3, ENSP000003537314EBI-3911467,EBI-2871277 MINT-8091083 I2D: score=2 STRING: ENSP00000353731
CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
CXCR3P496823, ENSP000003627954I2D: score=3 STRING: ENSP00000362795
ACKR3ENSP000002729284STRING: ENSP00000272928
ADCY2ENSP000003429524STRING: ENSP00000342952
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Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis IDA12782716
GO:0006952defense response TAS2115167
GO:0006954inflammatory response IEA--
GO:0006955immune response IEA--
GO:0006968cellular defense response TAS10570316

Find genes that share ontologies with CXCL9           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CXCL9

Selected Novoseek inferred chemical compound relationships for CXCL9 gene (see all 25)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
rantes 85.6 85 17489976 (5), 9856808 (3), 12164740 (3), 12864798 (3) (see all 59)
tarc 84.5 31 11310827 (3), 11920617 (3), 15927812 (3), 16583210 (3) (see all 18)
ccl3 81.1 26 17170049 (3), 12960247 (2), 19293190 (1), 19906920 (1) (see all 20)
ena 78 80.3 1 17444857 (1)
groalpha 67.8 7 15975968 (3), 19597126 (1), 9846975 (1), 11422029 (1)
ccl4 56.5 19 12960247 (2), 11178128 (1), 19265171 (1), 15591886 (1) (see all 14)
sdf 1 46 1 17384278 (1)
ifn-alpha 43.3 3 16736505 (1), 16571725 (1)
il 10 36.5 3 15975968 (2), 19340290 (1)
vegf 10.9 11 18644076 (4), 19160404 (1), 17459161 (1), 19010327 (1) (see all 6)



Find genes that share compounds with CXCL9           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CXCL9 gene: 
NM_002416.1  

Unigene Cluster for CXCL9:

Chemokine (C-X-C motif) ligand 9
Hs.77367  [show with all ESTs]
Unigene Representative Sequence: BC042178
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000264888(uc003hjh.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CXCL9 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate CXCL9:
hsa-miR-4316 hsa-miR-634 hsa-miR-3662 hsa-miR-103a-2* hsa-miR-4267
SwitchGear 3'UTR luciferase reporter plasmidCXCL9 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CXCL9
Predesigned siRNA for gene silencing in human, mouse, rat CXCL9
Clone
Products:
     
OriGene clones in human, mouse for CXCL9 (see all 7)
OriGene ORF clones in mouse, rat for CXCL9
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL9
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL9
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CXCL9
OriGene qSTAR qPCR primer pairs in human, mouse for CXCL9
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL9
  QuantiTect SYBR Green Assays in human, mouse, rat CXCL9
  QuantiFast Probe-based Assays in human, mouse, rat CXCL9

Additional mRNA sequence: 

AK311852.1 BC025745.1 BC042178.1 BC063122.1 BC095396.1 X72755.1 

4 DOTS entries:

DT.414759  DT.99955548  DT.95168680  DT.95168681 

Selected AceView cDNA sequences (see all 95):

AI918026 AI370217 BC042178 AI924853 AI784420 NM_002416 AA974879 T89439 
BQ016361 AA970872 AA131506 X72755 AA131406 T29117 AI686870 AA361362 
BF438664 AI424490 AI567906 AI819546 AW269682 CA748729 CB995904 BI835035 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXCL9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CXCL9 Expression
About this image


CXCL9 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         Body Subcutaneous White Adipose
 
 Liver (Hepatobiliary System)
         Mature Mesothelial Cells Hepatic Mesenchyme
 
 Blood (Cardiovascular System)
         Conventional Dendritic Cells I Spleen
 
 Spleen (Hematopoietic System)
         Conventional Dendritic Cells I Spleen
CXCL9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CXCL9 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.77367
    Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL9 (see all 13): 
          NFKB Signaling Targets in human mouse rat
          Antiviral Response in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Multiple Sclerosis in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CXCL9
OriGene qSTAR qPCR primer pairs in human, mouse for CXCL9
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL9
QuantiTect SYBR Green Assays in human, mouse, rat CXCL9
QuantiFast Probe-based Assays in human, mouse, rat CXCL9
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for CXCL9 gene from 5 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL91 chemokine (C-X-C motif) ligand 9 100(n)
100(a)
  471200  XM_526582.4  XP_526582.1 
mouse
(Mus musculus)
Mammalia Cxcl95 chemokine (C-X-C motif) ligand 9   --   5 (46.51 cM) 92321331 
cow
(Bos taurus)
Mammalia CXCL91 chemokine (C-X-C motif) ligand 9 78.76(n)
70.16(a)
  513990  NM_001113172.1  NP_001106643.1 
oppossum
(Monodelphis domestica)
Mammalia CXCL96
chemokine (C-X-C motif) ligand 9
41(a)
1 ↔ 1
5(31659288-31669715)
platypus
(Ornithorhynchus anatinus)
Mammalia --
Uncharacterized protein
34(a)
1 → many
Ultra362(72743-74905)
        Species with no ortholog for CXCL9

ENSEMBL Gene Tree for CXCL9 (if available)
TreeFam Gene Tree for CXCL9 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CXCL9 gene
CXCL102  
8 SIMAP similar genes for CXCL9 using alignment to 2 protein entries:     CXCL9_HUMAN (see all proteins):
PPBP    CXCL3    CXCL2    CXCL1    CXCL10    CXCL11
CXCL5    CXCL6

Find genes that share paralogs with CXCL9           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CXCL9 (see all 169)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1859266611,2
C--76922315(+) CAAATC/TCCTGA 1 -- ds50010--------
rs1440120521,2
C--76922338(+) CGCCCA/CCTTCG 1 -- ds50010--------
rs1919801851,2
C--76922355(+) CAAAGG/TGCTGG 1 -- ds50010--------
rs1466320591,2
C--76922412(+) AATCAA/GTGTTG 1 -- ds50010--------
rs10501761,2
C,F--76922749(-) ATATAC/TATACA 1 -- ut31 ese317Minor allele frequency- T:0.19MN NA WA CSA EA 994
rs103371,2
C,F--76922759(-) TTTATC/TATATA 1 -- ut3117Minor allele frequency- T:0.34MN NA WA EA 1300
rs353246031,2
C--76922817(-) CAGTAT/CATAAC 1 -- ut316Minor allele frequency- C:0.01MN NA 448
rs344889311,2
C,F--76922827(-) CACAGG/ATAGAC 1 -- ut315Minor allele frequency- A:0.01MN 400
rs1839413741,2
--76922840(+) ATGCAA/GGGTAA 1 -- ut310--------
rs1450946051,2
--76922928(+) GATTAG/TATAAG 1 -- ut310--------

HapMap Linkage Disequilibrium report for CXCL9 (76922428 - 76928641 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CXCL9:    About this table    
Variant IDTypeSubtypePubMed ID
nsv7363OTHER Inversion18451855

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601704    OMIM disorders: --

11 diseases for CXCL9:    
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endotheliitis    lymphomatoid granulomatosis    complex regional pain syndrome type 1    sydenham's chorea
chronic eosinophilic pneumonia    acrodermatitis    viral encephalitis    radiculopathy
tuberculosis    idiopathic pulmonary fibrosis    malaria

2 diseases from the University of Copenhagen DISEASES database for CXCL9:
Lung disease     Skin disease

Find genes that share disorders with CXCL9           About GenesLikeMe

Selected Novoseek inferred disease relationships for CXCL9 gene (see all 59)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 58 18 15210824 (1), 17473147 (1), 19155971 (1), 19276231 (1) (see all 16)
necrosis 48.5 36 9354680 (4), 9108380 (2), 19095263 (2), 20382085 (1) (see all 28)
sporadic inclusion body myositis 48.5 2 12965263 (1)
sarcoidosis pulmonary 42.2 2 17550373 (2)
lymphomatoid granulomatosis 40.3 1 9354680 (1)
immunopathology 39.7 1 16163626 (1)
fibrosis idiopathic pulmonary 38.2 1 19565490 (1)
keratoconjunctivitis vernal 36.8 1 14597036 (1)
bronchoalveolar lavage fluid 36.6 3 18644457 (1), 15956791 (1), 17550373 (1)
mycosis fungoides 36.5 1 15927812 (1)

Genetic Association Database (GAD): CXCL9
Human Genome Epidemiology (HuGE) Navigator: CXCL9 (11 documents)

Export disorders for CXCL9 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CXCL9 gene, integrated from 10 sources (see all 449):
(articles sorted by number of sources associating them with CXCL9)
    Utopia: connect your pdf to the dynamic
world of online information

  1. HuMig: a new human member of the chemokine family of cytokines. (PubMed id 8476424)1, 2, 3 Farber J.M. (Biochem. Biophys. Res. Commun. 1993)
  2. Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome. (PubMed id 19258635)1, 4, 9 Lau Y.L. and Peiris J.S. (Hong Kong Med J 2009)
  3. Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762)1, 2, 9 Tensen C.P.... Willemze R. (J. Invest. Dermatol. 1999)
  4. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
  6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  8. Polymorphisms of CXCR3-binding chemokines in type 1 diabetes. (PubMed id 19410617)1, 4 BrA1ck P....Ramos-Lopez E. (Hum. Immunol. 2009)
  9. Association of a CXCL9 polymorphism with pediatric Crohn's disease. (PubMed id 17892861)1, 4 Lacher M....Koletzko S. (Biochem. Biophys. Res. Commun. 2007)
  10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4283 HGNC: 7098 AceView: CXCL9 Ensembl:ENSG00000138755 euGenes: HUgn4283
ECgene: CXCL9 Kegg: 4283 H-InvDB: CXCL9

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CXCL9 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/CXCL9

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CXCL9 gene:
Search GeneIP for patents involving CXCL9

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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