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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CXCL9 Gene

protein-coding GIFtS: 57
GCID: GC04M076922

chemokine (C-X-C motif) ligand 9

(Previous name: monokine induced by gamma interferon )
(Previous symbols: CMK, MIG)

Explore 115 diseases affiliated with
CXCL9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Ligand 9¹ ²		Monokine Induced By Gamma Interferon¹ ²
MIG¹ ² ³ ⁵		Gamma-Interferon-Induced Monokine² ³
SCYB9¹ ² ³ ⁵		Monokine Induced By Interferon-Gamma² ³
CMK¹ ² ³		Small-Inducible Cytokine B9² ³
Humig¹ ²		C-X-C Motif Chemokine 9²
Crg-10¹		HuMIG³

External Ids:	HGNC: 7098¹	Entrez Gene: 4283²	Ensembl: ENSG00000138755⁷	OMIM: 601704⁵	UniProtKB: Q07325³

Export aliases for CXCL9 gene to outside databases

Previous GC identifers: GC04M076818 GC04M077112 GC04M077315 GC04M077380 GC04M077279 GC04M072674

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CXCL9:

The function of this gene has not been specifically defined; however, it is thought to be involved in T cell

trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of

cytokines. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325

Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and

inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3

Gene Wiki entry for CXCL9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CXCL9 gene promoter:
IRF-2 p53 AML1a STAT3 IRF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL9 promoter sequence

Search SABiosciences Chromatin IP Primers for CXCL9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q21.1 HGNC cytogenetic band: 4q21

CXCL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL9 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M076922: view genomic region (about GC identifiers)

Start:	76,922,428 bp from pter	End:	76,928,641 bp from pter
Size:	6,214 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325 (See protein sequence)

Recommended Name: C-X-C motif chemokine 9 precursor

Size: 125 amino acids; 14019 Da

Subcellular location: Secreted

Secondary accessions: Q503B4

Explore the universe of human proteins at neXtProt for CXCL9: NX_Q07325

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07325

CXCL9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002407.1

ENSEMBL proteins:

ENSP00000354901

Reactome Protein details: Q07325
Human Recombinant Protein Products for CXCL9:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CXCL9 Proteins Novus Biologicals CXCL9 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0009897	external side of plasma membrane	IEA	--

CXCL9 for ontologies About GeneDecksing

CXCL9 Antibody Products:

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Assay Products for CXCL9:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CXCL9 for domains About GeneDecksing

4 InterPro domains/families:

IPR001811 Chemokine_IL8-like_dom

IPR001089 Chemokine_CXC

IPR018048 Chemokine_CXC_CS

IPR027225 CXCL9

Graphical View of Domain Structure for InterPro Entry Q07325

ProtoNet protein and cluster: Q07325

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CXCL9_HUMAN, Q07325

Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and

inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3

Induction: By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	TAS	2115167
GO:0008009	chemokine activity	IEA	--

CXCL9 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CXCL9:

Increased gamma-H2AX phosphory

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cxcl9):

immune system

mortality/aging

CXCL9 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cxcl9^tm1Jmf for CXCL9

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CXCL9

miRNA Products:		OriGene 3'-UTR Clone: CXCL9 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL9
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL9:
		hsa-miR-4316 hsa-miR-634 hsa-miR-3662 hsa-miR-103a-2* hsa-miR-4267
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CXCL9

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CXCL9
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL9
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/9 pathways (see all 9)
PEDF Induced Signaling	1.00	RAR-Gamma-RXR-Alpha Degradation	0.54
MIF Mediated Glucocorticoid Regulation	0.73	STAT3 Pathway	0.47
MIF Regulation of Innate Immune Cells	0.71	Endothelin-1 Signaling Pathway	0.44
IL-6 Pathway	0.61	Cytokine-cytokine receptor interaction	0.26

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL9 (see all 17)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

4 BioSystems Pathways for CXCL9

	Type II interferon signaling (IFNG)
	Toll-like receptor signaling pathway
	CXCR3-mediated signaling events
	IL23-mediated signaling events

5/8 Reactome Pathways for CXCL9 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

3 Kegg Pathways (Kegg details for CXCL9):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Toll-like receptor signaling pathway

CXCL9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CXCL9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/165 Interacting proteins for CXCL9 (Q07325^{2, 3} ENSP00000354901⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 165)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487²^,³, ENSP00000353731⁴	MINT-8091083 I2D: score=2 STRING: ENSP00000353731
CCR3	P51677³, ENSP00000350003⁴	I2D: score=1 STRING: ENSP00000350003
CXCR3	P49682³, ENSP00000362795⁴	I2D: score=3 STRING: ENSP00000362795
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY4	ENSP00000312126⁴	STRING: ENSP00000312126

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	TAS	10903763
GO:0006952	defense response	TAS	2115167
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0006968	cellular defense response	TAS	10570316

CXCL9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CXCL9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CXCL9
10/25 Novoseek chemical compound relationships for CXCL9 gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	85.6	85	17489976 (5), 9856808 (3), 12164740 (3), 12864798 (3) (see all 59)
tarc	84.5	31	11310827 (3), 11920617 (3), 15927812 (3), 16583210 (3) (see all 18)
ccl3	81.1	26	17170049 (3), 12960247 (2), 19293190 (1), 19906920 (1) (see all 20)
ena 78	80.3	1	17444857 (1)
groalpha	67.8	7	15975968 (3), 19597126 (1), 9846975 (1), 11422029 (1)
ccl4	56.5	19	12960247 (2), 11178128 (1), 19265171 (1), 15591886 (1) (see all 14)
sdf 1	46	1	17384278 (1)
ifn-alpha	43.3	3	16736505 (1), 16571725 (1)
il 10	36.5	3	15975968 (2), 19340290 (1)
vegf	10.9	11	18644076 (4), 19160404 (1), 17459161 (1), 19010327 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about CXCL9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CXCL9 gene:

NM_002416.1

Unigene Cluster for CXCL9:

Chemokine (C-X-C motif) ligand 9

Hs.77367 [show with all ESTs]

Unigene Representative Sequence: BC042178

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000264888(uc003hjh.1)

miRNA Products:		OriGene 3'-UTR Clone: CXCL9 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL9
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL9:
		hsa-miR-4316 hsa-miR-634 hsa-miR-3662 hsa-miR-103a-2* hsa-miR-4267
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CXCL9

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL9

Additional cDNA sequence:

AK311852.1 BC025745.1 BC042178.1 BC063122.1 BC095396.1 X72755.1

4 DOTS entries:

DT.414759 DT.99955548 DT.95168680 DT.95168681

24/95 AceView cDNA sequences (see all 95):

AA131406 BC042178 T89439 AI784420 X72755 AI918026 AA974879 NM_002416

AI686870 AI924853 AI370217 AA970872 AA131506 BQ016361 T29117 AI433482

BC063122 CB961971 CD110190 BM855361 AA948337 AA361362 AI281492 AA115269

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CXCL9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CXCL9 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Adipose

Body Subcutaneous White Adipose

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CXCL9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXCL9

SOURCE GeneReport for Unigene cluster: Hs.77367

SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL9 (see all 13):

NFKB Signaling Targets in human mouse rat

Antiviral Response in human mouse rat

Angiogenic Growth Factors in human mouse rat

Multiple Sclerosis in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCL9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CXCL9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CXCL9 gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	si:ch211-202a12.7⁶ si:ch211-202a12.8⁶ (see all 4)	si:ch211-202a12.8 (see all 4)	33(a) 31(a) (see all 4)	many ↔ many many ↔ many (see all 4)	5(43700834-43701312) 5(43695254-43696157)

ENSEMBL Gene Tree for CXCL9 (if available)
TreeFam Gene Tree for CXCL9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CXCL9 gene

CXCL10²

8 SIMAP similar genes for CXCL9 using alignment to 2 protein entries: CXCL9_HUMAN (see all proteins):

PPBP CXCL3 CXCL2 CXCL1 CXCL10 CXCL11

CXCL5 CXCL6

CXCL9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185926661^1,2		--	76922315(+)	`CAAATC/TCCTGA`	1	--	ds500¹		0	--	--	--	--
rs144012052^1,2		--	76922338(+)	`CGCCCA/CCTTCG`	1	--	ds500¹		0	--	--	--	--
rs191980185^1,2		--	76922355(+)	`CAAAGG/TGCTGG`	1	--	ds500¹		0	--	--	--	--
rs146632059^1,2		--	76922412(+)	`AATCAA/GTGTTG`	1	--	ds500¹		0	--	--	--	--
rs1050176^1,2	C,F	--	76922749(-)	`ATATAC/TATACA`	1	--	ut3¹ ese³		17		MN NA WA CSA EA	994
rs10337^1,2	C,F	--	76922759(-)	`TTTATC/TATATA`	1	--	ut3¹		17		MN NA WA EA	1300
rs35324603^1,2	C	--	76922817(-)	`CAGTAT/CATAAC`	1	--	ut3¹		6		MN NA	448
rs34488931^1,2	C,F	--	76922827(-)	`CACAGG/ATAGAC`	1	--	ut3¹		5		MN	400
rs183941374^1,2		--	76922840(+)	`ATGCAA/GGGTAA`	1	--	ut3¹		0	--	--	--	--
rs145094605^1,2		--	76922928(+)	`GATTAG/TATAAG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CXCL9 (76922428 - 76928641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CXCL9: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCL9

DNA2.0 Custom Variant and Variant Library Synthesis for CXCL9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CXCL9 for disorders           About GeneDecksing

OMIM gene information: 601704    OMIM disorders: --

20/115 diseases for CXCL9 (see all 115):    About MalaCards

inclusion body myositis lymphomatoid granulomatosis hypersensitivity reaction type ii disease complex regional pain syndrome

sydenham's chorea chronic inflammatory demyelinating polyneuropathy mycosis fungoides demyelinating polyneuropathy

graft versus host disease lichen planus proliferative glomerulonephritis vernal keratoconjunctivitis

eosinophilic pneumonia erythema multiforme severe acute respiratory syndrome melioidosis

alopecia areata chronic eosinophilic pneumonia spotted fever visceral leishmaniasis

2 diseases from the University of Copenhagen DISEASES database for CXCL9:

Lung disease Skin disease

10/59 Novoseek disease relationships for CXCL9 gene (see all 59) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	58	18	15210824 (1), 17473147 (1), 19155971 (1), 19276231 (1) (see all 16)
necrosis	48.5	36	9354680 (4), 9108380 (2), 19095263 (2), 20382085 (1) (see all 28)
sporadic inclusion body myositis	48.5	2	12965263 (1)
sarcoidosis pulmonary	42.2	2	17550373 (2)
lymphomatoid granulomatosis	40.3	1	9354680 (1)
immunopathology	39.7	1	16163626 (1)
fibrosis idiopathic pulmonary	38.2	1	19565490 (1)
keratoconjunctivitis vernal	36.8	1	14597036 (1)
bronchoalveolar lavage fluid	36.6	3	18644457 (1), 15956791 (1), 17550373 (1)
mycosis fungoides	36.5	1	15927812 (1)

Human Genome Epidemiology (HuGE) Navigator: CXCL9 (11 documents)

Export disorders for CXCL9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CXCL9 gene, integrated from 9 sources (see all 434):
(articles sorted by number of sources associating them with CXCL9)

Utopia: connect your pdf to the dynamic
world of online information

HuMig: a new human member of the chemokine family of cytokines. (PubMed id 8476424)^{1, 2, 3} Farber J.M. (1993)
Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762)^{1, 2, 9} Tensen C.P.... Willemze R. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10). (PubMed id 9730616)^{1, 3} Erdel M....Werner-Felmayer G. (1998)
Involvement of the interferon-gamma-induced T cell-attracting chemokines, interferon-gamma-inducible 10-kd protein (CXCL10) and monokine induced by interferon-gamma (CXCL9), in the salivary gland lesions of patients with Sjogren's syndrome. (PubMed id 12384933)^{1, 9} Ogawa N....Sugai S. (2002)
Detection of interferon-gamma-inducible chemokines in human milk. (PubMed id 12856973)^{1, 9} Takahata Y....Hara T. (2003)
Constitutive nuclear factor kappaB activity is required to elicit interferon-gamma-induced expression of chemokine CXC ligand 9 (CXCL9) and CXCL10 in human tumour cell lines. (PubMed id 12946268)^{1, 9} Hiroi M. and Ohmori Y. (2003)
Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. (PubMed id 19344719)^{1, 9} Wasmuth H.E....Trautwein C. (2009)
ESAT6-induced IFNgamma and CXCL9 can differentiate severity of tuberculosis. (PubMed id 19340290)^{1, 9} Hasan Z....Hussain R. (2009)
VAP-1, Eotaxin3 and MIG as potential atherosclerotic triggers of severe calcified and stenotic human aortic valves: effects of statins. (PubMed id 17490641)^{1, 9} Anger T....Garlichs C.D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4283	HGNC: 7098	AceView: CXCL9	Ensembl:ENSG00000138755	euGenes: HUgn4283
ECgene: CXCL9	Kegg: 4283	H-InvDB: CXCL9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CXCL9	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CXCL9

Intellectual Property for CXCL9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CXCL9 gene:
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chemokine (C-X-C motif) ligand 9

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CXCL9 Gene

chemokine (C-X-C motif) ligand 9

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