CXCL9 Gene

Aliases
for CXCL9 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC04M076818 GC04M077112 GC04M077315 GC04M077380 GC04M077279 GC04M072674

Summaries
for CXCL9 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CXCL9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000004.11  NC_018915.2  NT_016354.20  

SwitchGear Promoter luciferase reporter plasmid: CXCL9 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL9

CXCL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076922:  view genomic region     (about GC identifiers)

Proteins
for CXCL9 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CXCL9: NX_Q07325

Explore proteomics data for CXCL9 at MOPED


See CXCL9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

CXCL9 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CXCL9 (CXCL9/MIG)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for CXCL9 OriGene Protein Over-expression Lysate for CXCL9 OriGene Custom MassSpec OriGene Custom Protein Services for CXCL9
	GenScript Purified and Recombinant Proteins for CXCL9
	Novus Biologicals CXCL9 Proteins Novus Biologicals CXCL9 Lysate
	Sino Biological Recombinant Protein for CXCL9 Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CXCL9
	GeneTex Proteins for CXCL9: (see all 3)                      MIG recombinant protein (GTX65490)
	antibodies-online proteins for CXCL9 (45 products)
	antibodies-online peptides for CXCL9

CXCL9 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CXCL9 (CXCL9/MIG)
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	Novus Biologicals CXCL9 Antibodies
	Abcam antibodies for CXCL9
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CXCL9
	antibodies-online antibodies for CXCL9 (67 products)

CXCL9 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CXCL9
	R&D Systems ELISAs for CXCL9 (CXCL9/MIG)         (see all)
	GenScript Custom Assay Services for CXCL9
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	eBioscience ELISAs for CXCL9:                       Human MIG Instant ELISA 128 tests
	antibodies-online kits for CXCL9 (37 products)

Domains /
Families
for CXCL9 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q07325

Find genes that share domains with CXCL9           About GenesLikeMe

Function
for CXCL9 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Cxcl9)

genOway: Develop your customized and physiologically relevant rodent model for CXCL9

miRNA Products:		miRTarBase miRNAs that target CXCL9: hsa-mir-335-5p (MIRT016944), hsa-mir-26b-5p (MIRT028888), hsa-mir-34a-5p (MIRT025283)
		Block miRNA regulation of human, mouse, rat CXCL9 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate CXCL9:
		hsa-miR-4316 hsa-miR-634 hsa-miR-3662 hsa-miR-103a-2* hsa-miR-4267
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL9 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CXCL9
		Predesigned siRNA for gene silencing in human, mouse, rat CXCL9

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CXCL9

Clone Products:		OriGene clones in human, mouse for CXCL9 (see all 7) OriGene ORF clones in mouse, rat for CXCL9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416)
		Sino Biological Human cDNA Clone for CXCL9
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL9

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL9
		Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL9

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9

Localization
for CXCL9 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
cytoskeleton	2
nucleus	2
plasma membrane	2

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for CXCL9 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CXCL9 About   (see all 13)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	PEDF Induced Signaling	MIF Regulation of Innate Immune Cells 0.94 IL-6 Pathway 0.61 MIF Mediated Glucocorticoid Regulation 0.94 STAT3 Pathway 0.47 PEDF Induced Signaling 0.73 Endothelin-1 Signaling Pathway 0.46 all-trans-Retinoic Acid Signaling in Brain 0.71 Cytokine-cytokine receptor interaction 0.43
2	Toll-like receptor signaling pathway	Toll-like receptor signaling pathway 0.94 Regulation of toll-like receptor signaling pathway 0.93 Toll-like receptor signaling pathway 0.94
3	Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions	Chemokine receptors bind chemokines 0.81 Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 0.81
4	Chemokine Signaling	Chemokine Signaling 0.33 Chemokine signaling pathway 0.33
5	Peptide ligand-binding receptors	Class A/1 (Rhodopsin-like receptors) 0.71 Peptide ligand-binding receptors 0.60 GPCR ligand binding 0.71 G alpha (i) signalling events 0.44

1 R&D Systems Pathway for CXCL9

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL9

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

5 BioSystems Pathways for CXCL9

	Type II interferon signaling (IFNG)
	Toll-like receptor signaling pathway
	CXCR3-mediated signaling events
	IL23-mediated signaling events
	Regulation of toll-like receptor signaling pathway

2 Reactome Pathways for CXCL9

	Chemokine receptors bind chemokines
	G alpha (i) signalling events

3 Kegg Pathways  (Kegg details for CXCL9)

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Toll-like receptor signaling pathway

Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

Drugs & Compounds
for CXCL9 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CXCL9 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CXCL9 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXCL9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Adipose (Muscoskeletal System)    fully expand to see all 2 entries
Body Subcutaneous White Adipose
Liver (Hepatobiliary System)
Mature Mesothelial Cells Hepatic Mesenchyme
Blood (Cardiovascular System)
Conventional Dendritic Cells I Spleen
Spleen (Hematopoietic System)
Conventional Dendritic Cells I Spleen

Primer Products:		OriGene qPCR primer pairs and template standards for CXCL9 OriGene qSTAR qPCR primer pairs in human, mouse for CXCL9
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL9
		QuantiTect SYBR Green Assays in human, mouse, rat CXCL9
		QuantiFast Probe-based Assays in human, mouse, rat CXCL9

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9

Orthologs
for CXCL9 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CXCL9 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CXCL9 gene

CXCL10²  

8 SIMAP similar genes for CXCL9 using alignment to 2 protein entries:     CXCL9_HUMAN (see all proteins):

PPBP    CXCL3    CXCL2    CXCL1    CXCL10    CXCL11

CXCL5    CXCL6

Find genes that share paralogs with CXCL9           About GenesLikeMe

Genomic Variants
for CXCL9 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CXCL9 (see all 169)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1859266611,2	C	--	76922315(+)	CAAATC/TCCTGA	1	--	ds5001		0	--	--	--	--
rs1440120521,2	C	--	76922338(+)	CGCCCA/CCTTCG	1	--	ds5001		0	--	--	--	--
rs1919801851,2	C	--	76922355(+)	CAAAGG/TGCTGG	1	--	ds5001		0	--	--	--	--
rs1466320591,2	C	--	76922412(+)	AATCAA/GTGTTG	1	--	ds5001		0	--	--	--	--
rs10501761,2	C,F	--	76922749(-)	ATATAC/TATACA	1	--	ut31 ese3		17		MN NA WA CSA EA	994
rs103371,2	C,F	--	76922759(-)	TTTATC/TATATA	1	--	ut31		17		MN NA WA EA	1300
rs353246031,2	C	--	76922817(-)	CAGTAT/CATAAC	1	--	ut31		6		MN NA	448
rs344889311,2	C,F	--	76922827(-)	CACAGG/ATAGAC	1	--	ut31		5		MN	400
rs1839413741,2		--	76922840(+)	ATGCAA/GGGTAA	1	--	ut31		0	--	--	--	--
rs1450946051,2		--	76922928(+)	GATTAG/TATAAG	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for CXCL9 (76922428 - 76928641 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CXCL9:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv7363	OTHER	Inversion	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CXCL9

DNA2.0 Custom Variant and Variant Library Synthesis for CXCL9

Disorders / Diseases
for CXCL9 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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13 diseases for CXCL9

Selected Novoseek inferred disease relationships for CXCL9 gene (see all 59)    About this table

Publications
for CXCL9 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. HuMig: a new human member of the chemokine family of cytokines. (PubMed id 8476424)^{1, 2, 3} Farber J.M. (Biochem. Biophys. Res. Commun. 1993)
2. Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome. (PubMed id 19258635)^{1, 4, 9} Lau Y.L. and Peiris J.S. (Hong Kong Med J 2009)
3. Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762)^{1, 2, 9} Tensen C.P.... Willemze R. (J. Invest. Dermatol. 1999)
4. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)^{1, 4} Wang Y....Huang W. (J. Hum. Genet. 2010)
5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (PLoS Genet. 2010)
6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
8. Polymorphisms of CXCR3-binding chemokines in type 1 diabetes. (PubMed id 19410617)^{1, 4} BrA1ck P....Ramos-Lopez E. (Hum. Immunol. 2009)
9. Association of a CXCL9 polymorphism with pediatric Crohn's disease. (PubMed id 17892861)^{1, 4} Lacher M....Koletzko S. (Biochem. Biophys. Res. Commun. 2007)
10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (J. Infect. Dis. 2007)

External Searches for CXCL9 gene

Genome Databases showing CXCL9 gene

Other Databases showing CXCL9 gene

Specialized Databases showing CXCL9 gene

Products
for CXCL9 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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