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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CXCL9 Gene

protein-coding GIFtS: 58
GCID: GC04M076922

Chemokine (C-X-C Motif) Ligand 9

(Previous name: monokine induced by gamma interferon)
(Previous symbols: CMK, MIG)

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Ligand 9¹ ²		Monokine Induced By Interferon-Gamma² ³
MIG¹ ² ³ ⁵		Small-Inducible Cytokine B9² ³
CMK¹ ² ³		Humig²
SCYB9² ³ ⁵		C-X-C Motif Chemokine 9²
Monokine Induced By Gamma Interferon¹ ²		crg-10²
Gamma-Interferon-Induced Monokine² ³		HuMIG³

External Ids:	HGNC: 7098¹	Entrez Gene: 4283²	Ensembl: ENSG00000138755⁷	OMIM: 601704⁵	UniProtKB: Q07325³

Export aliases for CXCL9 gene to outside databases

Previous GC identifers: GC04M076818 GC04M077112 GC04M077315 GC04M077380 GC04M077279 GC04M072674

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CXCL9 Gene:

The function of this gene has not been specifically defined; however, it is thought to be involved in T cell

trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of

cytokines. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL9 Gene:

CXCL9 (chemokine (C-X-C motif) ligand 9) is a protein-coding gene. Diseases associated with CXCL9 include lymphomatoid granulomatosis, and sydenham's chorea, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Toll-like receptor signaling pathway. GO annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CXCL10.

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325

Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and

inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3

Gene Wiki entry for CXCL9 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.2 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CXCL9 gene promoter:
IRF-2 p53 AML1a STAT3 IRF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL9 promoter sequence

Search SABiosciences Chromatin IP Primers for CXCL9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q21.1 HGNC cytogenetic band: 4q21

CXCL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL9 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M076922: view genomic region (about GC identifiers)

Start:	76,922,428 bp from pter	End:	76,928,641 bp from pter
Size:	6,214 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325 (See protein sequence)

Recommended Name: C-X-C motif chemokine 9 precursor

Size: 125 amino acids; 14019 Da

Subcellular location: Secreted

Secondary accessions: Q503B4

Explore the universe of human proteins at neXtProt for CXCL9: NX_Q07325

Explore proteomics data for CXCL9 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q07325

CXCL9 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_002407.1

ENSEMBL proteins:

ENSP00000354901

Reactome Protein details: Q07325
Human Recombinant Protein Products for CXCL9:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CXCL9 Proteins Novus Biologicals CXCL9 Lysates
	Sino Biological Recombinant Protein for CXCL9 Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0009897	external side of plasma membrane	IEA	--

CXCL9 for ontologies About GeneDecksing

CXCL9 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	LSBio Antibodies in human, mouse, rat for CXCL9

Assay Products for CXCL9:

	Browse Kits and Assays available from EMD Millipore
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	R&D Systems ELISAs for CXCL9 (CXCL9/MIG) (see all)
	GenScript Custom Assay Services for CXCL9
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ENDOLIG: Endogenous ligands

4 InterPro protein domains:

IPR001811 Chemokine_IL8-like_dom

IPR001089 Chemokine_CXC

IPR018048 Chemokine_CXC_CS

IPR027225 CXCL9

Graphical View of Domain Structure for InterPro Entry Q07325

ProtoNet protein and cluster: Q07325

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

CXCL9 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CXCL9_HUMAN, Q07325

Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and

inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3

Induction: By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	TAS	2115167
GO:0005515	protein binding	IPI	18275857
GO:0008009	chemokine activity	IEA	--

CXCL9 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CXCL9:

Increased gamma-H2AX phosphory

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cxcl9):

immune system

mortality/aging

CXCL9 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Cxcl9^tm1Jmf for CXCL9

inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCL9

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCL9

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL9

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL9

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL9
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL9:
		hsa-miR-4316 hsa-miR-634 hsa-miR-3662 hsa-miR-103a-2* hsa-miR-4267
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CXCL9
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		GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416)
		Sino Biological Human cDNA Clone for CXCL9
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL9
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		Sirion Biotech Customized lentivirus for stable overexpression of CXCL9 Customized lentivirus expression plasmids for stable overexpression of CXCL9

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL9
		Search LifeMap BioReagents cell lines for CXCL9

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CXCL9 About (see all 13)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

PEDF Induced Signaling

MIF Mediated Glucocorticoid Regulation	0.94	IL-6 Pathway	0.61
MIF Regulation of Innate Immune Cells	0.94	STAT3 Pathway	0.47
PEDF Induced Signaling	0.73	Endothelin-1 Signaling Pathway	0.46
all-trans-Retinoic Acid Signaling in Brain	0.71	Cytokine-cytokine receptor interaction	0.43

Toll-like receptor signaling pathway

Toll-like receptor signaling pathway

0.93

Toll-like receptor signaling pathway

0.93

Chemokine Signaling

Chemokine Signaling

0.33

Chemokine signaling pathway

0.33

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	0.71			Peptide ligand-binding receptors	0.60
	GPCR ligand binding	0.71			G alpha (i) signalling events	0.46

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.55
	GPCR downstream signaling	0.90

Pathways by source See SuperPaths
Show all pathways

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL9 (see all 17)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

4 BioSystems Pathways for CXCL9

	Type II interferon signaling (IFNG)
	Toll-like receptor signaling pathway
	IL23-mediated signaling events
	CXCR3-mediated signaling events

5/8 Reactome Pathways for CXCL9 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

3 Kegg Pathways (Kegg details for CXCL9):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Toll-like receptor signaling pathway

CXCL9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CXCL9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/165 Interacting proteins for CXCL9 (Q07325^{2, 3} ENSP00000354901⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 165)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487²^,³, ENSP00000353731⁴	MINT-8091083 I2D: score=2 STRING: ENSP00000353731
CCR3	P51677³, ENSP00000350003⁴	I2D: score=1 STRING: ENSP00000350003
CXCR3	P49682³, ENSP00000362795⁴	I2D: score=3 STRING: ENSP00000362795
ACKR3	ENSP00000272928⁴	STRING: ENSP00000272928
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	IEA	--
GO:0006952	defense response	TAS	2115167
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0006968	cellular defense response	TAS	10570316

CXCL9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CXCL9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CXCL9

10/25 Novoseek inferred chemical compound relationships for CXCL9 gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	85.6	85	17489976 (5), 9856808 (3), 12164740 (3), 12864798 (3) (see all 59)
tarc	84.5	31	11310827 (3), 11920617 (3), 15927812 (3), 16583210 (3) (see all 18)
ccl3	81.1	26	17170049 (3), 12960247 (2), 19293190 (1), 19906920 (1) (see all 20)
ena 78	80.3	1	17444857 (1)
groalpha	67.8	7	15975968 (3), 19597126 (1), 9846975 (1), 11422029 (1)
ccl4	56.5	19	12960247 (2), 11178128 (1), 19265171 (1), 15591886 (1) (see all 14)
sdf 1	46	1	17384278 (1)
ifn-alpha	43.3	3	16736505 (1), 16571725 (1)
il 10	36.5	3	15975968 (2), 19340290 (1)
vegf	10.9	11	18644076 (4), 19160404 (1), 17459161 (1), 19010327 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about CXCL9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CXCL9 gene:

NM_002416.1

Unigene Cluster for CXCL9:

Chemokine (C-X-C motif) ligand 9

Hs.77367 [show with all ESTs]

Unigene Representative Sequence: BC042178

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000264888(uc003hjh.1)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL9
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL9:
		hsa-miR-4316 hsa-miR-634 hsa-miR-3662 hsa-miR-103a-2* hsa-miR-4267
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CXCL9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL9

Clone Products:		OriGene clones in human, mouse for CXCL9 (see all 7) OriGene ORF clones in mouse, rat for CXCL9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL9
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Primer Products:		OriGene qPCR primer pairs and template standards for CXCL9 OriGene qSTAR qPCR primer pairs in human, mouse for CXCL9
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CXCL9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL9

Additional mRNA sequence:

AK311852.1 BC025745.1 BC042178.1 BC063122.1 BC095396.1 X72755.1

4 DOTS entries:

DT.414759 DT.99955548 DT.95168680 DT.95168681

24/95 AceView cDNA sequences (see all 95):

BQ016361 AI784420 AI918026 X72755 T89439 NM_002416 T29117 AA970872

BC042178 AI370217 AI924853 AI686870 AA131406 AA131506 AA974879 CB961971

AA865905 AA361362 AW514874 AI865101 BF438664 AI819546 BC025745 BF594047

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CXCL9 expression in normal human tissues (normalized intensities) CXCL9 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

CXCL9 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/9 selected tissues (see all 9) fully expand


Blood (Cardiovascular System) fully expand to see all 2 entries
Conventional Dendritic Cells I Spleen
alveolar macrophages

Adipose (Muscoskeletal System) fully expand to see all 2 entries
Body Subcutaneous White Adipose

Lymph (Hematopoietic System) fully expand to see all 2 entries
Lymphnode

Oral Cavity (Gastrointestinal Tract)
Salivary gland

Lung (Respiratory System)
alveolar macrophages

See CXCL9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CXCL9

SOURCE GeneReport for Unigene cluster: Hs.77367

SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL9 (see all 13):

NFKB Signaling Targets in human mouse rat

Antiviral Response in human mouse rat

Angiogenic Growth Factors in human mouse rat

Multiple Sclerosis in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CXCL9 OriGene qSTAR qPCR primer pairs in human, mouse for CXCL9
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for CXCL9 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cxcl9^{1 , 5}	chemokine (C-X-C motif) ligand 9^{1, 5}	77.69(n)¹ 71.9(a)¹		5 (46.51 cM)⁵ 17329¹ NM_008599.4¹ NP_032625.2¹ 92321331⁵

ENSEMBL Gene Tree for CXCL9 (if available)
TreeFam Gene Tree for CXCL9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CXCL9 gene

CXCL10²

8 SIMAP similar genes for CXCL9 using alignment to 2 protein entries: CXCL9_HUMAN (see all proteins):

PPBP CXCL3 CXCL2 CXCL1 CXCL10 CXCL11

CXCL5 CXCL6

CXCL9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185926661^1,2	C	--	76922315(+)	`CAAATC/TCCTGA`	1	--	ds500¹		0	--	--	--	--
rs144012052^1,2	C	--	76922338(+)	`CGCCCA/CCTTCG`	1	--	ds500¹		0	--	--	--	--
rs191980185^1,2	C	--	76922355(+)	`CAAAGG/TGCTGG`	1	--	ds500¹		0	--	--	--	--
rs146632059^1,2	C	--	76922412(+)	`AATCAA/GTGTTG`	1	--	ds500¹		0	--	--	--	--
rs1050176^1,2	C,F	--	76922749(-)	`ATATAC/TATACA`	1	--	ut3¹ ese³		17		MN NA WA CSA EA	994
rs10337^1,2	C,F	--	76922759(-)	`TTTATC/TATATA`	1	--	ut3¹		17		MN NA WA EA	1300
rs35324603^1,2	C	--	76922817(-)	`CAGTAT/CATAAC`	1	--	ut3¹		6		MN NA	448
rs34488931^1,2	C,F	--	76922827(-)	`CACAGG/ATAGAC`	1	--	ut3¹		5		MN	400
rs183941374^1,2		--	76922840(+)	`ATGCAA/GGGTAA`	1	--	ut3¹		0	--	--	--	--
rs145094605^1,2		--	76922928(+)	`GATTAG/TATAAG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CXCL9 (76922428 - 76928641 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for CXCL9: About this table

Variant ID	Type	Subtype	PubMed ID
nsv7363	OTHER	Inversion	18451855

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing CXCL9

DNA2.0 Custom Variant and Variant Library Synthesis for CXCL9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601704 OMIM disorders: --

114 diseases for CXCL9 (see first 20): About MalaCards

lymphomatoid granulomatosis sydenham's chorea complex regional pain syndrome type 1 chronic eosinophilic pneumonia

hypothyroidism, autoimmune inclusion body myositis eosinophilic pneumonia severe acute respiratory syndrome

melioidosis radiculopathy complex regional pain syndrome proliferative glomerulonephritis

chronic inflammatory demyelinating polyneuropathy viral encephalitis demyelinating polyneuropathy mycosis fungoides

keratitis pulmonary sarcoidosis interstitial lung disease paracoccidioidomycosis

lymphadenitis chorea spotted fever vernal keratoconjunctivitis

visceral leishmaniasis sarcoidosis keratoconjunctivitis paine syndrome

myositis extrapulmonary tuberculosis cerebral malaria erythema multiforme

pleurisy polyneuropathy idiopathic pulmonary fibrosis crohn's disease

acrodermatitis glomerulonephritis alopecia areata tuberculosis

bullous pemphigoid pemphigus vulgaris dermatitis hypersensitivity reaction type ii disease

malaria encephalitis autoimmune thyroiditis pneumonia

lichen planus sjogren's syndrome bronchitis burkitt's lymphoma

uveitis allergic asthma alopecia leishmaniasis

pulmonary tuberculosis hypothyroidism myocarditis cutaneous t cell lymphoma

pulmonary fibrosis cystitis synovitis skin disease

dermatomyositis primary biliary cirrhosis pemphigus psoriasis

multiple sclerosis graves' disease b-cell chronic lymphocytic leukemia influenza

atopic dermatitis hepatitis b virus infection diabetic retinopathy chronic obstructive pulmonary disease

bronchiolitis systemic lupus erythematosus arthritis graft versus host disease

herpes simplex asthma atherosclerosis hepatocellular carcinoma

bipolar disorder ulcerative colitis aortic aneurysm meningioma

rheumatoid arthritis renal cell carcinoma multiple myeloma type 1 diabetes

cystic fibrosis cerebritis myeloma hepatitis c

lupus erythematosus hepatitis b chronic lymphocytic leukemia b-cell lymphomas

liver disease endotheliitis melanoma hepatitis

inflammatory bowel disease thyroiditis neuroblastoma retinitis

ovarian cancer breast cancer colorectal cancer lung cancer

leukemia pancreatitis

2 diseases from the University of Copenhagen DISEASES database for CXCL9:

Lung disease Skin disease

CXCL9 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/59 Novoseek inferred disease relationships for CXCL9 gene (see all 59) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	58	18	15210824 (1), 17473147 (1), 19155971 (1), 19276231 (1) (see all 16)
necrosis	48.5	36	9354680 (4), 9108380 (2), 19095263 (2), 20382085 (1) (see all 28)
sporadic inclusion body myositis	48.5	2	12965263 (1)
sarcoidosis pulmonary	42.2	2	17550373 (2)
lymphomatoid granulomatosis	40.3	1	9354680 (1)
immunopathology	39.7	1	16163626 (1)
fibrosis idiopathic pulmonary	38.2	1	19565490 (1)
keratoconjunctivitis vernal	36.8	1	14597036 (1)
bronchoalveolar lavage fluid	36.6	3	18644457 (1), 15956791 (1), 17550373 (1)
mycosis fungoides	36.5	1	15927812 (1)

Genetic Association Database (GAD): CXCL9
Human Genome Epidemiology (HuGE) Navigator: CXCL9 (11 documents)

Export disorders for CXCL9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CXCL9 gene, integrated from 9 sources (see all 445):
(articles sorted by number of sources associating them with CXCL9)

Utopia: connect your pdf to the dynamic
world of online information

HuMig: a new human member of the chemokine family of cytokines. (PubMed id 8476424)^{1, 2, 3} Farber J.M. (1993)
Association of cytokine and chemokine gene polymorphi sms with severe acute respiratory syndrome. (PubMed id 19258635)^{1, 4, 9} Lau Y.L. and Peiris J.S. (2009)
Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762)^{1, 2, 9} Tensen C.P.... Willemze R. (1999)
Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)^{1, 4} Wang Y....Huang W. (2010)
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (2010)
Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (2010)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (2009)
Polymorphisms of CXCR3-binding chemokines in type 1 diabetes. (PubMed id 19410617)^{1, 4} BrA1ck P....Ramos-Lopez E. (2009)
Association of a CXCL9 polymorphism with pediatric Crohn's disease. (PubMed id 17892861)^{1, 4} Lacher M....Koletzko S. (2007)
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4283	HGNC: 7098	AceView: CXCL9	Ensembl:ENSG00000138755	euGenes: HUgn4283
ECgene: CXCL9	Kegg: 4283	H-InvDB: CXCL9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CXCL9	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CXCL9

Intellectual Property for CXCL9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CXCL9 gene:
Search GeneIP for patents involving CXCL9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Chemokine (C-X-C Motif) Ligand 9

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Autoimmune Diseases
Melanoma
Dermatitis
sepsis
Malaria
immunopathology
Lymphoma T-Cell
Dermatitis Atopic
Bacterial Infections
Carcinoma
Keratoconjunctivitis Vernal
Skin Diseases
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CXCL9 Gene

Chemokine (C-X-C Motif) Ligand 9

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