Aliases for CXCL9 Gene
Aliases for CXCL9 Gene
External Ids for CXCL9 Gene
- HGNC: 7098
- Entrez Gene: 4283
- Ensembl: ENSG00000138755
- OMIM: 601704
- UniProtKB: Q07325
Previous HGNC Symbols for CXCL9 Gene
- CMK
- MIG
Previous GeneCards Identifiers for CXCL9 Gene
- GC04M076818
- GC04M077112
- GC04M077315
- GC04M077380
- GC04M077279
- GC04M076922
- GC04M072674
Summaries for CXCL9 Gene
-
This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]
GeneCards Summary for CXCL9 Gene
CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Inclusion Body Myositis and Sydenham's Chorea. Among its related pathways are Peptide ligand-binding receptors and ERK Signaling. GO annotations related to this gene include cytokine activity and CXCR3 chemokine receptor binding. An important paralog of this gene is CXCL10.
UniProtKB/Swiss-Prot for CXCL9 Gene
-
Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL9 Gene
Genomics for CXCL9 Gene
Regulatory Elements for CXCL9 Gene
Enhancers for CXCL9 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CXCL9 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CXCL9 gene promoter:
Regulatory Element Products
Genomic Location for CXCL9 Gene
- Chromosome:
- 4
- Start:
- 76,001,275 bp from pter
- End:
- 76,007,523 bp from pter
- Size:
- 6,249 bases
- Orientation:
- Minus strand
Genomic View for CXCL9 Gene
Genes around CXCL9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q21.1 by Ensembl
- 4q21 by Entrez Gene
- 4q21 by HGNC
CXCL9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CXCL9 Gene
Proteins for CXCL9 Gene
-
Protein details for CXCL9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07325-CXCL9_HUMAN
- Recommended name:
- C-X-C motif chemokine 9
- Protein Accession:
- Q07325
- Q503B4
Protein attributes for CXCL9 Gene
- Size:
- 125 amino acids
- Molecular mass:
- 14019 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CXCL9 Gene
Other Protein References for CXCL9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CXCL9 (CXCL9/MIG)
- Novus Biologicals Antibodies for CXCL9
-
Cloud-Clone Corp. Antibodies for CXCL9
- Invitrogen Antibodies for CXCL9
- antibodies-online Antibodies for CXCL9: See all 144
- GeneTex CXCL9 antibody for CXCL9
-
Santa Cruz Biotechnology (SCBT) Antibodies for CXCL9
Protein Products
- R&D Systems Proteins and Enzymes for CXCL9 (CXCL9/MIG)
- Search Origene for MassSpec and Protein Over-expression Lysates for CXCL9
- Origene Custom Protein Services for CXCL9
- Sino Biological Recombinant Proteins for CXCL9
- Browse Sino Biological Cell Lysates
-
Cloud-Clone Corp. Proteins for CXCL9
- antibodies-online Proteins for CXCL9: See all 77
- Search antibodies-online for peptides
- GeneTex MIG protein (GTX29721) for CXCL9
- GeneTex MIG Recombinant Protein (Active) (GTX48398-PRO) for CXCL9
- GeneTex MIG recombinant protein (GTX65174) for CXCL9
- Abcam proteins for CXCL9
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CXCL9
- R&D Systems Luminex Assays, Proteome Profiler Antibody Arrays, ELISpot and FluoroSpot Kits, ELISAs, and other biochemical assays for CXCL9 (CXCL9/MIG)
- eBioscience Human MIG Instant ELISA 128 tests for CXCL9
- antibodies-online Kits for CXCL9: See all 65
- Abcam assays for CXCL9
No data available for DME Specific Peptides for CXCL9 Gene
Domains & Families for CXCL9 Gene
Gene Families for CXCL9 Gene
Protein Domains for CXCL9 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CXCL9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q07325- Family:
-
- Belongs to the intercrine alpha (chemokine CxC) family.
Function for CXCL9 Gene
Molecular function for CXCL9 Gene
- UniProtKB/Swiss-Prot Function:
- Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
- UniProtKB/Swiss-Prot Induction:
- By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 18275857 |
Phenotypes for CXCL9 Gene
- GenomeRNAi human phenotypes for CXCL9:
Animal Model Products
-
ViGene Biosciences lentiviral particle packaged cDNA for CXCL9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CXCL9 gene
- Search ViGene Biosciences for CXCL9
CRISPR Products
-
OriGene CRISPR knockouts for CXCL9
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCL9
- GenScript: Design CRISPR guide RNA sequences for CXCL9
miRNA for CXCL9 Gene
- miRTarBase miRNAs that target CXCL9
miRNA Products
- Search ViGene Biosciences for CXCL9
Clone Products
- OriGene clones in human for CXCL9
- OriGene ORF clones in human,mouse,rat for CXCL9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CXCL9
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CXCL9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CXCL9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CXCL9 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL9 Gene
Localization for CXCL9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CXCL9 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytosol | 2 |
| nucleus | 2 |
| cytoskeleton | 1 |
No data available for Gene Ontology (GO) - Cellular Components for CXCL9 Gene
Pathways & Interactions for CXCL9 Gene
More details on SuperPathways for CXCL9| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
.47
|
|
| 2 | Peptide ligand-binding receptors | ||
| 3 | Toll-like receptor signaling pathway | ||
| 4 | ERK Signaling |
.61
|
|
| 5 | Signaling by GPCR |
Pathways by source for CXCL9 Gene
5 BioSystems pathways for CXCL9 Gene
8 Reactome pathways for CXCL9 Gene
3 KEGG pathways for CXCL9 Gene
1 R&D Systems pathway for CXCL9 Gene
17 Qiagen pathways for CXCL9 Gene
Interacting Proteins for CXCL9 Gene
Selected Interacting proteins:
Q07325-CXCL9_HUMAN
ENSP00000354901
for CXCL9 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002690 | positive regulation of leukocyte chemotaxis | IBA | -- |
| GO:0006935 | chemotaxis | IDA | 12782716 |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0006955 | immune response | IEA,IBA | -- |
| GO:0007165 | signal transduction | TAS | 10201891 |
No data available for SIGNOR curated interactions for CXCL9 Gene
Drugs & Compounds for CXCL9 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CXCL9 Gene
mRNA/cDNA for CXCL9 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (95) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CXCL9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CXCL9
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCL9
- GenScript: Design CRISPR guide RNA sequences for CXCL9
miRNA Products
- Search ViGene Biosciences for CXCL9
Clone Products
- OriGene clones in human for CXCL9
- OriGene ORF clones in human,mouse,rat for CXCL9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CXCL9
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for CXCL9 Gene
mRNA differential expression in normal tissues according to GTEx for CXCL9 Gene
This gene is overexpressed in Lung (x6.0).
SOURCE GeneReport for Unigene cluster for CXCL9 Gene Hs.77367
Primer Products
-
OriGene qPCR primer pairs for CXCL9
-
OriGene qPCR primer pairs and template standards for CXCL9
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CXCL9 Gene
Orthologs for CXCL9 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CXCL9 35 |
|
||
| CXCL9 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | CXCL9 35 |
|
||
| CXCL9 36 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | CXCL9 36 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cxcl9 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
OneToMany |
- Species with no ortholog for CXCL9:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CXCL9 Gene
(8) SIMAP similar genes for CXCL9 Gene using alignment to 2 proteins:
Variants for CXCL9 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2276885 | -- | 76,007,576(-) | GATAC(C/T)AGCCA | upstream-variant-2KB | |
| rs2276886 | -- | 76,007,275(-) | ATTTG(A/G)TCAGT | intron-variant | |
| rs6532083 | -- | 76,008,048(+) | TAATA(A/G)ATTGG | upstream-variant-2KB | |
| rs6532084 | -- | 76,008,440(+) | cttac(A/G)cctgc | upstream-variant-2KB | |
| rs35322408 | -- | 76,007,731(-) | AAAGG(C/T)TATCA | upstream-variant-2KB |
Residual Variation Intolerance Score:
61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.43% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CXCL9 Gene
Disorders for CXCL9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inclusion body myositis |
|
|
| sydenham's chorea |
|
|
| endotheliitis |
|
|
| encephalitis |
|
|
| lymphomatoid granulomatosis |
|
Search CXCL9 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CXCL9
No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL9 Gene
Publications for CXCL9 Gene
- HuMig: a new human member of the chemokine family of cytokines. (PMID: 8476424) Farber J.M. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 67
- Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathy. (PMID: 18413205) Higurashi M. … Yamada K. (J. Diabetes Complicat. 2009) 3 23
- ESAT6-induced IFNgamma and CXCL9 can differentiate severity of tuberculosis. (PMID: 19340290) Hasan Z. … Hussain R. (PLoS ONE 2009) 3 23
- Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. (PMID: 19344719) Wasmuth H.E. … Trautwein C. (Gastroenterology 2009) 3 23
- Modelling of the membrane receptor CXCR3 and its complexes with CXCL9, CXCL10 and CXCL11 chemokines: putative target for new drug design. (PMID: 19800124) Trotta T. … Colonna G. (Mol. Immunol. 2009) 3 23
Products for CXCL9 Gene
- R&D Systems Antibodies for CXCL9 (CXCL9/MIG)
- R&D Systems Proteins and Enzymes for CXCL9 (CXCL9/MIG)
- R&D Systems ELISAs, ELISpot and FluoroSpot Kits, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CXCL9 (CXCL9/MIG)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Custom Assay ServicesOriGene ELISA Kits for CXCL9
- Search Origene for MassSpec and Protein Over-expression Lysates for CXCL9
- Origene Custom Protein Services for CXCL9
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for CXCL9
- Browse OriGene Inhibitory RNA Products For CXCL9
- OriGene qPCR primer pairs for CXCL9
- OriGene qPCR primer pairs and template standards for CXCL9
- OriGene CRISPR knockouts for CXCL9
- OriGene clones in human for CXCL9
- OriGene ORF clones in human,mouse,rat for CXCL9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Purified and Recombinant Proteins for CXCL9
- GenScript Custom Purified and Recombinant Proteins Services for CXCL9
- GenScript Custom Assay Services for CXCL9
- GenScript Custom overexpressing Cell Line Services for CXCL9
- GenScript: Design CRISPR guide RNA sequences for CXCL9
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CXCL9
- Novus Biologicals Antibodies for CXCL9
- Novus Biologicals proteins and lysates for CXCL9
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Search for Antibodies for CXCL9 at Abcam
- Abcam proteins for CXCL9
- Abcam assays for CXCL9
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for CXCL9
- Cloud-Clone Corp. Proteins for CXCL9
- antibodies-online Antibodies for CXCL9: See all 144
- antibodies-online Kits for CXCL9: See all 65
- antibodies-online Proteins for CXCL9: See all 77
- Search antibodies-online for peptides
- GeneTex CXCL9 antibody for CXCL9
- GeneTex MIG protein (GTX29721) for CXCL9
- GeneTex MIG Recombinant Protein (Active) (GTX48398-PRO) for CXCL9
- GeneTex MIG recombinant protein (GTX65174) for CXCL9
- ViGene Biosciences adenoviral particle packaged cDNA for CXCL9 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CXCL9 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CXCL9 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CXCL9 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CXCL9 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CXCL9 gene
- Search ViGene Biosciences for CXCL9
- Search ViGene Biosciences for CXCL9
- Santa Cruz Biotechnology (SCBT) Antibodies for CXCL9
- Search Santa Cruz Biotechnology (SCBT) for CXCL9 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CXCL9
Sources for CXCL9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (17) IUBMB
- (18) KEGG
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- (20) STRING
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
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- (64) Nature
- (65) NCBI
- (66) OriGene
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- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon