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CXCL9 Gene(Protein Coding)

C-X-C Motif Chemokine Ligand 9

GCID:
GC04M076001
GIFtS:
46
Genes Participants
UDN Logo

Aliases for CXCL9 Gene

Aliases for CXCL9 Gene

  • C-X-C Motif Chemokine Ligand 9 2 3 5
  • Monokine Induced By Gamma Interferon 2 3
  • Monokine Induced By Interferon-Gamma 3 4
  • Gamma-Interferon-Induced Monokine 3 4
  • Chemokine (C-X-C Motif) Ligand 9 2 3
  • Small-Inducible Cytokine B9 3 4
  • Humig 3 4
  • SCYB9 3 4
  • CMK 3 4
  • MIG 3 4
  • C-X-C Motif Chemokine 9 3
  • Crg-10 3

External Ids for CXCL9 Gene

Previous HGNC Symbols for CXCL9 Gene

  • CMK
  • MIG

Previous GeneCards Identifiers for CXCL9 Gene

  • GC04M076818
  • GC04M077112
  • GC04M077315
  • GC04M077380
  • GC04M077279
  • GC04M076922
  • GC04M072674

Summaries for CXCL9 Gene

Entrez Gene Summary for CXCL9 Gene

  • This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL9 Gene

CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Endotheliitis and Sydenham Chorea. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and CXCR3 chemokine receptor binding. An important paralog of this gene is CXCL10.

UniProtKB/Swiss-Prot for CXCL9 Gene

  • Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.

Gene Wiki entry for CXCL9 Gene

Additional gene information for CXCL9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL9 Gene

Genomics for CXCL9 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CXCL9 Gene

Promoters and enhancers for CXCL9 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I076007 Promoter 0.8 EPDnew 550.8 0.0 -6 0.1 STAT1 GATA3 JUND JUN CXCL9 ART3 GC04M075923
GH04I076042 Enhancer 0.5 FANTOM5 72.9 -34.9 -34911 0.2 JUN JUNB FOS ATF2 CXCL11 CXCL9 CXCL10 NAAA ART3 GC04P076101
GH04I076027 Enhancer 1.1 FANTOM5 Ensembl ENCODE 27.4 -20.9 -20911 1.1 MEIS2 NFIC STAT1 NFIA NFIB SOX6 YY1 ART3 CXCL9 CXCL10 CXCL11 SDAD1 NAAA GC04M075923 RPL36P8
GH04I076059 Enhancer 0.9 FANTOM5 ENCODE 29.6 -52.5 -52452 1.2 ZGPAT ZNF512 CREB1 ZNF384 HNF4A ZBTB40 SPI1 NR2C2 ART3 CXCL10 CXCL9 NAAA CXCL11 SDAD1 LOC101928809 GC04P076101
GH04I076029 Enhancer 0.4 FANTOM5 46.9 -22.0 -21967 0.2 ZNF316 MAFK CXCL9 CXCL10 CXCL11 SDAD1 ART3 NAAA GC04M075923 RPL36P8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CXCL9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXCL9 gene promoter:

Genomic Locations for CXCL9 Gene

Genomic Locations for CXCL9 Gene
chr4:76,001,275-76,007,523
(GRCh38/hg38)
Size:
6,249 bases
Orientation:
Minus strand
chr4:76,922,428-76,928,641
(GRCh37/hg19)

Genomic View for CXCL9 Gene

Genes around CXCL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CXCL9 Gene

Proteins for CXCL9 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CXCL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07325-CXCL9_HUMAN
    Recommended name:
    C-X-C motif chemokine 9
    Protein Accession:
    Q07325
    Secondary Accessions:
    • Q503B4

    Protein attributes for CXCL9 Gene

    Size:
    125 amino acids
    Molecular mass:
    14019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL9 Gene

Post-translational modifications for CXCL9 Gene

No Post-translational modifications

Other Protein References for CXCL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CXCL9

No data available for DME Specific Peptides for CXCL9 Gene

Domains & Families for CXCL9 Gene

Gene Families for CXCL9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CXCL9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07325

UniProtKB/Swiss-Prot:

CXCL9_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL9: view

Function for CXCL9 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CXCL9 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells.

Gene Ontology (GO) - Molecular Function for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 2115167
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity IDA,TAS 12782716
GO:0048248 CXCR3 chemokine receptor binding IDA 12782716
genes like me logo Genes that share ontologies with CXCL9: view
genes like me logo Genes that share phenotypes with CXCL9: view

Animal Model Products

miRNA for CXCL9 Gene

miRTarBase miRNAs that target CXCL9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL9 Gene

Localization for CXCL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL9 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
cytoskeleton 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,TAS --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CXCL9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL9 Gene

Pathways & Interactions for CXCL9 Gene

genes like me logo Genes that share pathways with CXCL9: view

Gene Ontology (GO) - Biological Process for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS,IDA 12782716
GO:0006952 defense response TAS 2115167
GO:0006954 inflammatory response TAS,IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with CXCL9: view

No data available for SIGNOR curated interactions for CXCL9 Gene

Drugs & Compounds for CXCL9 Gene

Products:

  1. Drug

(20) Drugs for CXCL9 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adrenocorticotropic Hormone Pharma 174
beta-endorphin Pharma Full agonist, Agonist 147
Hormone Antagonists Pharma 13948
Hormones Pharma 15237
Hormones, Hormone Substitutes, and Hormone Antagonists Pharma 13936

(11) Additional Compounds for CXCL9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL9: view

Transcripts for CXCL9 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CXCL9 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(95) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL9 Gene

Chemokine (C-X-C motif) ligand 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL9 Gene

No ASD Table

Relevant External Links for CXCL9 Gene

GeneLoc Exon Structure for
CXCL9
ECgene alternative splicing isoforms for
CXCL9

Expression for CXCL9 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL9 Gene

mRNA expression in normal human tissues for CXCL9 Gene
mRNA expression by BioGPS for CXCL9 GenemRNA expression by GTEx for CXCL9 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL9 Gene

This gene is overexpressed in Lung (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of CXCL9 Gene:

CXCL9

SOURCE GeneReport for Unigene cluster for CXCL9 Gene:

Hs.77367

Evidence on tissue expression from TISSUES for CXCL9 Gene

  • Blood(4.6)
  • Skin(4.4)
  • Lymph node(3.5)
  • Spleen(2.9)
  • Intestine(2.7)
  • Lung(2.6)
  • Liver(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with CXCL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL9 Gene

Orthologs for CXCL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CXCL9 33 34
  • 100 (n)
cow
(Bos Taurus)
 Mammalia CXCL9 33 34
  • 78.76 (n)
mouse
(Mus musculus)
 Mammalia Cxcl9 34
  • 68 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CXCL9 34
  • 41 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 34 (a)
 OneToMany
Species where no ortholog for CXCL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL9 Gene

ENSEMBL:
Gene Tree for CXCL9 (if available)
TreeFam:
Gene Tree for CXCL9 (if available)

Paralogs for CXCL9 Gene

Paralogs for CXCL9 Gene

(8) SIMAP similar genes for CXCL9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CXCL9: view

Variants for CXCL9 Gene

Sequence variations from dbSNP and Humsavar for CXCL9 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1001123018 -- 76,006,913(-) T/C intron_variant
rs1001781734 -- 76,006,563(-) A/G intron_variant
rs1002110613 -- 76,005,253(-) G/T intron_variant
rs1002274101 -- 76,003,757(-) T/C intron_variant
rs1002789859 -- 76,005,590(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL9 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER inversion 18451855

Variation tolerance for CXCL9 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL9 Gene

Disorders for CXCL9 Gene

MalaCards: The human disease database

(24) MalaCards diseases for CXCL9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endotheliitis
sydenham chorea
  • saint vitus dance
inclusion body myositis
  • ibm
mycosis fungoides
  • mf
lichen planus
  • lichen ruber planus
- elite association - COSMIC cancer census association via MalaCards
Search CXCL9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCL9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL9 Gene

Publications for CXCL9 Gene

  1. HuMig: a new human member of the chemokine family of cytokines. (PMID: 8476424) Farber JM (Biochemical and biophysical research communications 1993) 2 3 4 58
  2. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 44 58
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  5. Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathy. (PMID: 18413205) Higurashi M … Yamada K (Journal of diabetes and its complications 2009) 3 22 58

Products for CXCL9 Gene

Sources for CXCL9 Gene

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