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CXCL9 Gene

protein-coding GIFtS: 57
GCID: GC04M076922

Chemokine (C-X-C Motif) Ligand 9

(Previous name: monokine induced by gamma interferon)
(Previous symbols: CMK, MIG)

Microbiology & Infectious Diseases Congress

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Chemokine (C-X-C Motif) Ligand 9¹ ²		Monokine Induced By Interferon-Gamma² ³
MIG¹ ² ³ ⁵		Small-Inducible Cytokine B9² ³
CMK¹ ² ³		Humig²
SCYB9² ³ ⁵		C-X-C Motif Chemokine 9²
Monokine Induced By Gamma Interferon¹ ²		crg-10²
Gamma-Interferon-Induced Monokine² ³		HuMIG³

External Ids:	HGNC: 7098¹	Entrez Gene: 4283²	Ensembl: ENSG00000138755⁷	OMIM: 601704⁵	UniProtKB: Q07325³

Export aliases for CXCL9 gene to outside databases

Previous GC identifers: GC04M076818 GC04M077112 GC04M077315 GC04M077380 GC04M077279 GC04M072674

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCL9 Gene:

The function of this gene has not been specifically defined; however, it is thought to be involved in T cell

trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of

cytokines. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL9 Gene:

CXCL9 (chemokine (C-X-C motif) ligand 9) is a protein-coding gene. Diseases associated with CXCL9 include lymphomatoid granulomatosis, and sydenham's chorea. GO annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CXCL10.

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325

Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and

inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3

Gene Wiki entry for CXCL9 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000004.12 NC_018915.2 NT_016354.20

Regulatory elements:

Regulatory transcription factor binding sites in the CXCL9 gene promoter:
IRF-2 p53 AML1a STAT3 IRF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL9 promoter sequence

Search Chromatin IP Primers for CXCL9

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q21.1 HGNC cytogenetic band: 4q21

CXCL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL9 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M076922: view genomic region (about GC identifiers)

Start:	76,922,428 bp from pter	End:	76,928,641 bp from pter
Size:	6,214 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325 (See protein sequence)

Recommended Name: C-X-C motif chemokine 9 precursor

Size: 125 amino acids; 14019 Da

Secondary accessions: Q503B4

Explore the universe of human proteins at neXtProt for CXCL9: NX_Q07325

Explore proteomics data for CXCL9 at MOPED

See CXCL9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002407.1

ENSEMBL proteins:

ENSP00000354901

Reactome Protein details: Q07325

CXCL9 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CXCL9 (CXCL9/MIG)
	Browse recombinant and purified proteins available from Enzo Life Sciences
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	GenScript Purified and Recombinant Proteins for CXCL9
	Novus Biologicals CXCL9 Proteins Novus Biologicals CXCL9 Lysate
	Sino Biological Recombinant Protein for CXCL9 Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

CXCL9 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CXCL9 (CXCL9/MIG)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CXCL9
	Novus Biologicals CXCL9 Antibodies
	Abcam antibodies for CXCL9
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CXCL9
	LSBio Antibodies in human, mouse, rat for CXCL9

CXCL9 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CXCL9
	R&D Systems ELISAs for CXCL9 (CXCL9/MIG) (see all)
	GenScript Custom Assay Services for CXCL9
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ENDOLIG: Endogenous ligands

4 InterPro protein domains:

IPR001811 Chemokine_IL8-like_dom

IPR001089 Chemokine_CXC

IPR018048 Chemokine_CXC_CS

IPR027225 CXCL9

Graphical View of Domain Structure for InterPro Entry Q07325

ProtoNet protein and cluster: Q07325

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

CXCL9 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CXCL9_HUMAN, Q07325

Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and

inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3

Induction: By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	TAS	2115167
GO:0005515	protein binding	IPI	18275857
GO:0008009	chemokine activity	IDA	12782716
GO:0048248	CXCR3 chemokine receptor binding	IDA	12782716

CXCL9 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CXCL9:

Increased gamma-H2AX phosphory

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cxcl9):

hematopoietic system

immune system

mortality/aging

CXCL9 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Cxcl9^tm1Jmf for CXCL9

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCL9

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCL9

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL9

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL9

miRNA Products:		miRTarBase miRNAs that target CXCL9: hsa-mir-335-5p (MIRT016944), hsa-mir-26b-5p (MIRT028888), hsa-mir-34a-5p (MIRT025283)

		Block miRNA regulation of human, mouse, rat CXCL9 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate CXCL9:
		hsa-miR-4316 hsa-miR-634 hsa-miR-3662 hsa-miR-103a-2* hsa-miR-4267
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL9 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CXCL9
		Predesigned siRNA for gene silencing in human, mouse, rat CXCL9

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CXCL9

Clone Products:		OriGene clones in human, mouse for CXCL9 (see all 7) OriGene ORF clones in mouse, rat for CXCL9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416)
		Sino Biological Human cDNA Clone for CXCL9
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL9

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL9
		Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL9

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CXCL9_HUMAN, Q07325: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
cytoskeleton	2
nucleus	2
plasma membrane	2

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0009897	external side of plasma membrane	IEA	--

CXCL9 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CXCL9 About (see all 13)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

PEDF Induced Signaling

MIF Regulation of Innate Immune Cells	0.94	IL-6 Pathway	0.61
MIF Mediated Glucocorticoid Regulation	0.94	STAT3 Pathway	0.47
PEDF Induced Signaling	0.73	Endothelin-1 Signaling Pathway	0.46
all-trans-Retinoic Acid Signaling in Brain	0.71	Cytokine-cytokine receptor interaction	0.43

Toll-like receptor signaling pathway

	Toll-like receptor signaling pathway	0.94			Regulation of toll-like receptor signaling pathway	0.93
	Toll-like receptor signaling pathway	0.94

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Chemokine receptors bind chemokines

0.81

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

0.81

Chemokine Signaling

Chemokine signaling pathway

0.33

Chemokine Signaling

0.33

Peptide ligand-binding receptors

	Class A/1 (Rhodopsin-like receptors)	0.71			Peptide ligand-binding receptors	0.60
	GPCR ligand binding	0.71			G alpha (i) signalling events	0.44

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for CXCL9

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL9 (see all 17)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

5 BioSystems Pathways for CXCL9

	Type II interferon signaling (IFNG)
	Toll-like receptor signaling pathway
	CXCR3-mediated signaling events
	IL23-mediated signaling events
	Regulation of toll-like receptor signaling pathway

2 Reactome Pathways for CXCL9

	Chemokine receptors bind chemokines
	G alpha (i) signalling events

3 Kegg Pathways (Kegg details for CXCL9):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Toll-like receptor signaling pathway

CXCL9 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including CXCL9 (see all 13):

NFKB Signaling Targets in human mouse rat

Antiviral Response in human mouse rat

Angiogenic Growth Factors in human mouse rat

Multiple Sclerosis in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Interactions:

GeneGlobe Interaction Network for CXCL9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CXCL9 (Q07325^{1, 2, 3} ENSP00000354901⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 165)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487¹^,²^,³, ENSP00000353731⁴	EBI-3911467,EBI-2871277 MINT-8091083 I2D: score=2 STRING: ENSP00000353731
CCR3	P51677³, ENSP00000350003⁴	I2D: score=1 STRING: ENSP00000350003
CXCR3	P49682³, ENSP00000362795⁴	I2D: score=3 STRING: ENSP00000362795
ACKR3	ENSP00000272928⁴	STRING: ENSP00000272928
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952

About this table

Gene Ontology (GO): Selected biological process terms (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	IDA	12782716
GO:0006952	defense response	TAS	2115167
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	IEA	--
GO:0006968	cellular defense response	TAS	10570316

CXCL9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CXCL9

Selected Novoseek inferred chemical compound relationships for CXCL9 gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	85.6	85	17489976 (5), 9856808 (3), 12164740 (3), 12864798 (3) (see all 59)
tarc	84.5	31	11310827 (3), 11920617 (3), 15927812 (3), 16583210 (3) (see all 18)
ccl3	81.1	26	17170049 (3), 12960247 (2), 19293190 (1), 19906920 (1) (see all 20)
ena 78	80.3	1	17444857 (1)
groalpha	67.8	7	15975968 (3), 19597126 (1), 9846975 (1), 11422029 (1)
ccl4	56.5	19	12960247 (2), 11178128 (1), 19265171 (1), 15591886 (1) (see all 14)
sdf 1	46	1	17384278 (1)
ifn-alpha	43.3	3	16736505 (1), 16571725 (1)
il 10	36.5	3	15975968 (2), 19340290 (1)
vegf	10.9	11	18644076 (4), 19160404 (1), 17459161 (1), 19010327 (1) (see all 6)

CXCL9 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CXCL9 gene:

NM_002416.1

Unigene Cluster for CXCL9:

Chemokine (C-X-C motif) ligand 9

Hs.77367 [show with all ESTs]

Unigene Representative Sequence: BC042178

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000264888(uc003hjh.1)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat CXCL9 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate CXCL9:
		hsa-miR-4316 hsa-miR-634 hsa-miR-3662 hsa-miR-103a-2* hsa-miR-4267
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL9 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CXCL9
		Predesigned siRNA for gene silencing in human, mouse, rat CXCL9

Clone Products:		OriGene clones in human, mouse for CXCL9 (see all 7) OriGene ORF clones in mouse, rat for CXCL9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL9

Primer Products:		OriGene qPCR primer pairs and template standards for CXCL9 OriGene qSTAR qPCR primer pairs in human, mouse for CXCL9
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CXCL9
		QuantiTect SYBR Green Assays in human, mouse, rat CXCL9
		QuantiFast Probe-based Assays in human, mouse, rat CXCL9

Additional mRNA sequence:

AK311852.1 BC025745.1 BC042178.1 BC063122.1 BC095396.1 X72755.1

4 DOTS entries:

DT.414759 DT.99955548 DT.95168680 DT.95168681

Selected AceView cDNA sequences (see all 95):

AI918026 AI370217 BC042178 AI924853 AI784420 NM_002416 AA974879 T89439

BQ016361 AA970872 AA131506 X72755 AA131406 T29117 AI686870 AA361362

BF438664 AI424490 AI567906 AI819546 AW269682 CA748729 CB995904 BI835035

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXCL9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

CXCL9 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Adipose (Muscoskeletal System) fully expand to see all 2 entries
Body Subcutaneous White Adipose

Liver (Hepatobiliary System)
Mature Mesothelial Cells Hepatic Mesenchyme

Blood (Cardiovascular System)
Conventional Dendritic Cells I Spleen

Spleen (Hematopoietic System)
Conventional Dendritic Cells I Spleen

CXCL9 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CXCL9 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.77367

Pathway & Disease-focused RT² Profiler PCR Arrays including CXCL9 (see all 13):

NFKB Signaling Targets in human mouse rat

Antiviral Response in human mouse rat

Angiogenic Growth Factors in human mouse rat

Multiple Sclerosis in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CXCL9 OriGene qSTAR qPCR primer pairs in human, mouse for CXCL9
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CXCL9
		QuantiTect SYBR Green Assays in human, mouse, rat CXCL9
		QuantiFast Probe-based Assays in human, mouse, rat CXCL9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for CXCL9 gene from Selected species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cxcl9⁵	chemokine (C-X-C motif) ligand 9	--		5 (46.51 cM) 92321331

ENSEMBL Gene Tree for CXCL9 (if available)
TreeFam Gene Tree for CXCL9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CXCL9 gene

CXCL10²

8 SIMAP similar genes for CXCL9 using alignment to 2 protein entries: CXCL9_HUMAN (see all proteins):

PPBP CXCL3 CXCL2 CXCL1 CXCL10 CXCL11

CXCL5 CXCL6

CXCL9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185926661^1,2	C	--	76922315(+)	`CAAATC/TCCTGA`	1	--	ds500¹		0	--	--	--	--
rs144012052^1,2	C	--	76922338(+)	`CGCCCA/CCTTCG`	1	--	ds500¹		0	--	--	--	--
rs191980185^1,2	C	--	76922355(+)	`CAAAGG/TGCTGG`	1	--	ds500¹		0	--	--	--	--
rs146632059^1,2	C	--	76922412(+)	`AATCAA/GTGTTG`	1	--	ds500¹		0	--	--	--	--
rs1050176^1,2	C,F	--	76922749(-)	`ATATAC/TATACA`	1	--	ut3¹ ese³		17		MN NA WA CSA EA	994
rs10337^1,2	C,F	--	76922759(-)	`TTTATC/TATATA`	1	--	ut3¹		17		MN NA WA EA	1300
rs35324603^1,2	C	--	76922817(-)	`CAGTAT/CATAAC`	1	--	ut3¹		6		MN NA	448
rs34488931^1,2	C,F	--	76922827(-)	`CACAGG/ATAGAC`	1	--	ut3¹		5		MN	400
rs183941374^1,2		--	76922840(+)	`ATGCAA/GGGTAA`	1	--	ut3¹		0	--	--	--	--
rs145094605^1,2		--	76922928(+)	`GATTAG/TATAAG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CXCL9 (76922428 - 76928641 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for CXCL9: About this table

Variant ID	Type	Subtype	PubMed ID
nsv7363	OTHER	Inversion	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CXCL9

DNA2.0 Custom Variant and Variant Library Synthesis for CXCL9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601704 OMIM disorders: --

120 diseases for CXCL9 (see first 20):
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lymphomatoid granulomatosis sydenham's chorea complex regional pain syndrome type 1 chronic eosinophilic pneumonia

hypothyroidism, autoimmune inclusion body myositis eosinophilic pneumonia complex regional pain syndrome

radiculopathy melioidosis severe acute respiratory syndrome pulmonary sarcoidosis

interstitial lung disease chronic inflammatory demyelinating polyneuropathy paine syndrome viral encephalitis

proliferative glomerulonephritis demyelinating polyneuropathy sarcoidosis lymphadenitis

myositis pleurisy mycosis fungoides paracoccidioidomycosis

keratitis spotted fever vernal keratoconjunctivitis pemphigus vulgaris

erythema multiforme keratoconjunctivitis chorea visceral leishmaniasis

extrapulmonary tuberculosis cerebral malaria polyneuropathy acrodermatitis

pemphigus alopecia areata idiopathic pulmonary fibrosis glomerulonephritis

bullous pemphigoid tuberculosis hypersensitivity reaction type ii disease dermatitis

encephalitis sjogren's syndrome burkitt's lymphoma pneumonia

malaria bronchitis cystitis hepatitis b virus infection

lichen planus alopecia autoimmune thyroiditis allergic asthma

uveitis leishmaniasis cryoglobulinemia pulmonary tuberculosis

hypothyroidism cutaneous t cell lymphoma myocarditis skin disease

pulmonary fibrosis primary biliary cirrhosis b-cell chronic lymphocytic leukemia synovitis

dermatomyositis influenza atopic dermatitis psoriasis

myoclonus multiple sclerosis hepatitis b chronic lymphocytic leukemia

diabetic retinopathy systemic lupus erythematosus graves' disease sepsis

bronchiolitis arthritis asthma herpes simplex

graft versus host disease diabetic nephropathy atherosclerosis hepatocellular carcinoma

ulcerative colitis bipolar disorder aortic aneurysm meningioma

rheumatoid arthritis crohn's disease renal cell carcinoma hepatitis

multiple myeloma cystic fibrosis hepatitis c lupus erythematosus

type 1 diabetes inflammatory bowel disease cerebritis myeloma

hepatitis c virus b-cell lymphomas melanoma thyroiditis

endotheliitis liver disease neuroblastoma retinitis

hiv-1 ovarian cancer breast cancer colorectal cancer

leukemia lung cancer pancreatitis alzheimer's disease

2 diseases from the University of Copenhagen DISEASES database for CXCL9:

Lung disease Skin disease

CXCL9 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Selected Novoseek inferred disease relationships for CXCL9 gene (see all 59) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	58	18	15210824 (1), 17473147 (1), 19155971 (1), 19276231 (1) (see all 16)
necrosis	48.5	36	9354680 (4), 9108380 (2), 19095263 (2), 20382085 (1) (see all 28)
sporadic inclusion body myositis	48.5	2	12965263 (1)
sarcoidosis pulmonary	42.2	2	17550373 (2)
lymphomatoid granulomatosis	40.3	1	9354680 (1)
immunopathology	39.7	1	16163626 (1)
fibrosis idiopathic pulmonary	38.2	1	19565490 (1)
keratoconjunctivitis vernal	36.8	1	14597036 (1)
bronchoalveolar lavage fluid	36.6	3	18644457 (1), 15956791 (1), 17550373 (1)
mycosis fungoides	36.5	1	15927812 (1)

Genetic Association Database (GAD): CXCL9
Human Genome Epidemiology (HuGE) Navigator: CXCL9 (11 documents)

Export disorders for CXCL9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CXCL9 gene, integrated from 10 sources (see all 449):
(articles sorted by number of sources associating them with CXCL9)

Utopia: connect your pdf to the dynamic
world of online information

HuMig: a new human member of the chemokine family of cytokines. (PubMed id 8476424)^{1, 2, 3} Farber J.M. (Biochem. Biophys. Res. Commun. 1993)
Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome. (PubMed id 19258635)^{1, 4, 9} Lau Y.L. and Peiris J.S. (Hong Kong Med J 2009)
Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762)^{1, 2, 9} Tensen C.P.... Willemze R. (J. Invest. Dermatol. 1999)
Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)^{1, 4} Wang Y....Huang W. (J. Hum. Genet. 2010)
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (PLoS Genet. 2010)
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
Polymorphisms of CXCR3-binding chemokines in type 1 diabetes. (PubMed id 19410617)^{1, 4} BrA1ck P....Ramos-Lopez E. (Hum. Immunol. 2009)
Association of a CXCL9 polymorphism with pediatric Crohn's disease. (PubMed id 17892861)^{1, 4} Lacher M....Koletzko S. (Biochem. Biophys. Res. Commun. 2007)
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (J. Infect. Dis. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4283	HGNC: 7098	AceView: CXCL9	Ensembl:ENSG00000138755	euGenes: HUgn4283
ECgene: CXCL9	Kegg: 4283	H-InvDB: CXCL9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CXCL9	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CXCL9

Intellectual Property for CXCL9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CXCL9 gene:
Search GeneIP for patents involving CXCL9

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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CXCL9 Gene

Chemokine (C-X-C Motif) Ligand 9

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Autoimmune Diseases
Melanoma
Dermatitis
sepsis
Malaria
immunopathology
Lymphoma T-Cell
Dermatitis Atopic
Bacterial Infections
Carcinoma
Keratoconjunctivitis Vernal
Skin Diseases
Atherosclerosis
Breast Cancer
Neovascularization
Sjogrens Syndrome
Lyme Arthritis
Asthma
HEPATOCELLULAR CARCINOMA
Mycosis Fungoides
Carcinoma Renal Cell
Cancer
Proliferative glomerulonephritis
Dermatitis Allergic Contact
Pemphigus Vulgaris
Uveitis
Influenza
Lymphoma
Dermatitis Contact
mammary tumor
Sporadic Inclusion Body Myositis
RENAL DISEASE
Bronchoalveolar Lavage Fluid
effusion
Sarcoidosis Pulmonary
HIV Infections
Multiple Sclerosis
Lymphoproliferative Disorders
Burkitt Lymphoma
Inflammation
Tuberculosis
solid tumor
Melioidosis
Carcinoma Squamous Cell
SKIN LESION
Paracoccidioidomycosis
Psoriasis
Lymphomatoid Granulomatosis
Sarcoidosis
Rheumatoid Arthritis
Tumors
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Glomerulonephritis
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FIBROSIS IDIOPATHIC PULMONARY
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CXCL9 Gene

Chemokine (C-X-C Motif) Ligand 9

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