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Aliases for CXCL9 Gene

Aliases for CXCL9 Gene

  • Chemokine (C-X-C Motif) Ligand 9 2 3
  • SCYB9 3 4 6
  • MIG 3 4 6
  • Monokine Induced By Gamma Interferon 2 3
  • Monokine Induced By Interferon-Gamma 3 4
  • Gamma-Interferon-Induced Monokine 3 4
  • Small-Inducible Cytokine B9 3 4
  • Humig 3 4
  • CMK 3 4
  • C-X-C Motif Chemokine 9 3
  • Crg-10 3

External Ids for CXCL9 Gene

Previous HGNC Symbols for CXCL9 Gene

  • CMK
  • MIG

Previous GeneCards Identifiers for CXCL9 Gene

  • GC04M076818
  • GC04M077112
  • GC04M077315
  • GC04M077380
  • GC04M077279
  • GC04M076922
  • GC04M072674

Summaries for CXCL9 Gene

Entrez Gene Summary for CXCL9 Gene

  • This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL9 Gene

CXCL9 (Chemokine (C-X-C Motif) Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include lymphomatoid granulomatosis and endotheliitis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CXCL10.

UniProtKB/Swiss-Prot for CXCL9 Gene

  • Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3

Gene Wiki entry for CXCL9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL9 Gene

Genomics for CXCL9 Gene

Regulatory Elements for CXCL9 Gene

Genomic Location for CXCL9 Gene

Start:
76,001,275 bp from pter
End:
76,007,488 bp from pter
Size:
6,214 bases
Orientation:
Minus strand

Genomic View for CXCL9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL9 Gene

Proteins for CXCL9 Gene

  • Protein details for CXCL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07325-CXCL9_HUMAN
    Recommended name:
    C-X-C motif chemokine 9
    Protein Accession:
    Q07325
    Secondary Accessions:
    • Q503B4

    Protein attributes for CXCL9 Gene

    Size:
    125 amino acids
    Molecular mass:
    14019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL9 Gene

Proteomics data for CXCL9 Gene at MOPED

Post-translational modifications for CXCL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for CXCL9 Gene

Domains for CXCL9 Gene

Gene Families for CXCL9 Gene

HGNC:

Protein Domains for CXCL9 Gene

Suggested Antigen Peptide Sequences for CXCL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07325

UniProtKB/Swiss-Prot:

CXCL9_HUMAN :
  • Q07325
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL9: view

Function for CXCL9 Gene

Molecular function for CXCL9 Gene

UniProtKB/Swiss-Prot Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells

Gene Ontology (GO) - Molecular Function for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 2115167
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity IDA 12782716
GO:0048248 CXCR3 chemokine receptor binding IDA 12782716
genes like me logo Genes that share ontologies with CXCL9: view

Phenotypes for CXCL9 Gene

genes like me logo Genes that share phenotypes with CXCL9: view

Animal Models for CXCL9 Gene

MGI Knock Outs for CXCL9:

Animal Model Products

CRISPR Products

miRNA for CXCL9 Gene

miRTarBase miRNAs that target CXCL9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCL9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CXCL9 Gene

Localization for CXCL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL9 Gene COMPARTMENTS Subcellular localization image for CXCL9 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CXCL9: view

Pathways for CXCL9 Gene

genes like me logo Genes that share pathways with CXCL9: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006935 chemotaxis IDA 12782716
GO:0006952 defense response TAS 2115167
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with CXCL9: view

Compounds for CXCL9 Gene

(25) Novoseek inferred chemical compound relationships for CXCL9 Gene

Compound -log(P) Hits PubMed IDs
rantes 85.6 80
tarc 84.5 29
ccl3 81.1 23
ena 78 80.3 1
groalpha 67.8 6
genes like me logo Genes that share compounds with CXCL9: view

Transcripts for CXCL9 Gene

mRNA/cDNA for CXCL9 Gene

(95) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL9 Gene

Chemokine (C-X-C motif) ligand 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCL9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL9 Gene

No ASD Table

Relevant External Links for CXCL9 Gene

GeneLoc Exon Structure for
CXCL9
ECgene alternative splicing isoforms for
CXCL9

Expression for CXCL9 Gene

mRNA expression in normal human tissues for CXCL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL9 Gene

This gene is overexpressed in Lung (6.0).

SOURCE GeneReport for Unigene cluster for CXCL9 Gene Hs.77367

genes like me logo Genes that share expressions with CXCL9: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for CXCL9 Gene

Orthologs for CXCL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL9 35
  • 100 (n)
  • 100 (a)
CXCL9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL9 35
  • 78.76 (n)
  • 70.16 (a)
CXCL9 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl9 16
Cxcl9 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CXCL9 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
OneToMany
Species with no ortholog for CXCL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL9 Gene

ENSEMBL:
Gene Tree for CXCL9 (if available)
TreeFam:
Gene Tree for CXCL9 (if available)

Paralogs for CXCL9 Gene

Paralogs for CXCL9 Gene

Selected SIMAP similar genes for CXCL9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CXCL9: view

Variants for CXCL9 Gene

Sequence variations from dbSNP and Humsavar for CXCL9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2276885 -- 76,007,576(-) GATAC(C/T)AGCCA upstream-variant-2KB
rs2276886 -- 76,007,275(-) ATTTG(A/G)TCAGT intron-variant
rs6532083 -- 76,008,048(+) TAATA(A/G)ATTGG upstream-variant-2KB
rs6532084 -- 76,008,440(+) cttac(A/G)cctgc upstream-variant-2KB
rs35322408 -- 76,007,731(-) AAAGG(C/T)TATCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXCL9 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855

Relevant External Links for CXCL9 Gene

HapMap Linkage Disequilibrium report
CXCL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL9 Gene

Disorders for CXCL9 Gene

(2) University of Copenhagen DISEASES for CXCL9 Gene

(59) Novoseek inferred disease relationships for CXCL9 Gene

Disease -log(P) Hits PubMed IDs
inflammation 58 16
necrosis 48.5 33
sporadic inclusion body myositis 48.5 1
sarcoidosis pulmonary 42.2 2
lymphomatoid granulomatosis 40.3 1

Relevant External Links for CXCL9

Genetic Association Database (GAD)
CXCL9
Human Genome Epidemiology (HuGE) Navigator
CXCL9
genes like me logo Genes that share disorders with CXCL9: view

No data available for UniProtKB/Swiss-Prot for CXCL9 Gene

Publications for CXCL9 Gene

  1. Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PMID: 10233762) Tensen C.P. … Willemze R. (J. Invest. Dermatol. 1999) 3 4 23
  2. HuMig: a new human member of the chemokine family of cytokines. (PMID: 8476424) Farber J.M. (Biochem. Biophys. Res. Commun. 1993) 2 3 4
  3. Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome. (PMID: 19258635) Lau Y.L. … Peiris J.S. (Hong Kong Med J 2009) 3 48
  4. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen C.L. … Janssen R. (Pediatr. Infect. Dis. J. 2009) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CXCL9 Gene

Sources for CXCL9 Gene

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