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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL9 Gene

protein-coding   GIFtS: 58
GCID: GC04M076922

Chemokine (C-X-C Motif) Ligand 9

(Previous name: monokine induced by gamma interferon)
(Previous symbols: CMK, MIG)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-X-C Motif) Ligand 91 2     Monokine Induced By Interferon-Gamma2 3
MIG1 2 3 5     Small-Inducible Cytokine B92 3
CMK1 2 3     Humig2
SCYB92 3 5     C-X-C Motif Chemokine 92
Monokine Induced By Gamma Interferon1 2     crg-102
Gamma-Interferon-Induced Monokine2 3     HuMIG3

External Ids:    HGNC: 70981   Entrez Gene: 42832   Ensembl: ENSG000001387557   OMIM: 6017045   UniProtKB: Q073253   

Export aliases for CXCL9 gene to outside databases

Previous GC identifers: GC04M076818 GC04M077112 GC04M077315 GC04M077380 GC04M077279 GC04M072674


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CXCL9 Gene:
The function of this gene has not been specifically defined; however, it is thought to be involved in T cell
trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of
cytokines. (provided by RefSeq, Jul 2008)

GeneCards Summary for CXCL9 Gene: 
CXCL9 (chemokine (C-X-C motif) ligand 9) is a protein-coding gene. Diseases associated with CXCL9 include lymphomatoid granulomatosis, and sydenham's chorea, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Toll-like receptor signaling pathway. GO annotations related to this gene include cytokine activity and chemokine activity. An important paralog of this gene is CXCL10.

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325
Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and
inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3

Gene Wiki entry for CXCL9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL9 gene promoter:
         IRF-2   p53   AML1a   STAT3   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL9 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21

CXCL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL9 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M076922:  view genomic region     (about GC identifiers)

Start:
76,922,428 bp from pter      End:
76,928,641 bp from pter
Size:
6,214 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325 (See protein sequence)
Recommended Name: C-X-C motif chemokine 9 precursor  
Size: 125 amino acids; 14019 Da
Subcellular location: Secreted
Secondary accessions: Q503B4

Explore the universe of human proteins at neXtProt for CXCL9: NX_Q07325

Explore proteomics data for CXCL9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07325

  • CXCL9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXCL9 Protein Expression
    REFSEQ proteins: NP_002407.1  
    ENSEMBL proteins: 
     ENSP00000354901  
    Reactome Protein details: Q07325
    Human Recombinant Protein Products for CXCL9: 
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    OriGene Protein Over-expression Lysate for CXCL9
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CXCL9
    GenScript Purified and Recombinant Proteins for CXCL9
    Novus Biologicals CXCL9 Proteins
    Novus Biologicals CXCL9 Lysates
    Sino Biological Recombinant Protein for CXCL9
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0009897external side of plasma membrane IEA--

    CXCL9 for ontologies           About GeneDecksing



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    Abcam antibodies for CXCL9
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS
     IPR027225 CXCL9

    Graphical View of Domain Structure for InterPro Entry Q07325

    ProtoNet protein and cluster: Q07325

    UniProtKB/Swiss-Prot: CXCL9_HUMAN, Q07325
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    CXCL9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCL9_HUMAN, Q07325
    Function: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and
    inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3
    Induction: By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity TAS2115167
    GO:0005515protein binding IPI18275857
    GO:0008009chemokine activity IEA--
         
    CXCL9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CXCL9:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cxcl9):
     immune system  mortality/aging 

    CXCL9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cxcl9tm1Jmf for CXCL9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCL9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCL9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL9 

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    SwitchGear 3'UTR luciferase reporter plasmidCXCL9 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CXCL9 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL9 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    4 BioSystems Pathways for CXCL9
        Type II interferon signaling (IFNG)
    Toll-like receptor signaling pathway
    IL23-mediated signaling events
    CXCR3-mediated signaling events


    5/8        Reactome Pathways for CXCL9 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CXCL9):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Toll-like receptor signaling pathway


    CXCL9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/165 Interacting proteins for CXCL9 (Q073252, 3 ENSP000003549014) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8091083 I2D: score=2 STRING: ENSP00000353731
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    CXCR3P496823, ENSP000003627954I2D: score=3 STRING: ENSP00000362795
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006952defense response TAS2115167
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0006968cellular defense response TAS10570316

    CXCL9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL9

    10/25 Novoseek inferred chemical compound relationships for CXCL9 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 85.6 85 17489976 (5), 9856808 (3), 12164740 (3), 12864798 (3), 15126779 (3), 12544874 (3), 15975968 (3), 11600578 (2), 17393453 (2), 10385645 (2), 17540042 (2), 15606618 (2), 11110785 (1), 15655045 (1), 9466968 (1), 16602032 (1), 16378994 (1), 17211148 (1), 16025563 (1), 11159181 (1), 8993355 (1), 19220953 (1), 19160404 (1), 18498809 (1), 17922833 (1), 17444857 (1), 16864900 (1), 16778661 (1), 12570673 (1), 11580984 (1), 11564831 (1), 11564157 (1), 1418604 (1), 12829909 (1), 20182399 (1), 20153811 (1), 19229703 (1), 18159995 (1), 17539322 (1), 11714650 (1), 9120285 (1), 17993576 (1), 17315139 (1), 16195357 (1), 18793417 (1), 19100801 (1), 16634894 (1), 15591886 (1), 14517275 (1), 11869363 (1), 18226915 (1), 17264811 (1), 17015796 (1), 12489485 (1), 17300233 (1), 15663962 (1), 12537753 (1), 18207025 (1), 11598160 (1) (see top 4)
    tarc 84.5 31 11310827 (3), 11920617 (3), 15927812 (3), 16583210 (3), 16634894 (2), 16453150 (2), 15113590 (2), 11423172 (1), 19783681 (1), 9500790 (1), 15208597 (1), 18524543 (1), 18243665 (1), 18514095 (1), 11159181 (1), 15805991 (1), 15591886 (1), 15975968 (1) (see top 4)
    ccl3 81.1 26 17170049 (3), 12960247 (2), 19293190 (1), 19906920 (1), 19001077 (1), 15591886 (1), 19406226 (1), 16907924 (1), 19067439 (1), 20136829 (1), 19010327 (1), 17228365 (1), 17393419 (1), 11141325 (1), 17295707 (1), 20182399 (1), 19274438 (1), 17912012 (1), 19439524 (1), 17640964 (1) (see top 4)
    ena 78 80.3 1 17444857 (1)
    groalpha 67.8 7 15975968 (3), 19597126 (1), 9846975 (1), 11422029 (1)
    ccl4 56.5 19 12960247 (2), 11178128 (1), 19265171 (1), 15591886 (1), 20182399 (1), 17295707 (1), 11141325 (1), 20136829 (1), 17393419 (1), 19067439 (1), 16907924 (1), 19274438 (1), 19293190 (1), 17912012 (1) (see top 4)
    sdf 1 46 1 17384278 (1)
    ifn-alpha 43.3 3 16736505 (1), 16571725 (1)
    il 10 36.5 3 15975968 (2), 19340290 (1)
    vegf 10.9 11 18644076 (4), 19160404 (1), 17459161 (1), 19010327 (1), 15063730 (1), 18159995 (1) (see top 4)

    Search CenterWatch for drugs/clinical trials and news about CXCL9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CXCL9 gene: 
    NM_002416.1  

    Unigene Cluster for CXCL9:

    Chemokine (C-X-C motif) ligand 9
    Hs.77367  [show with all ESTs]
    Unigene Representative Sequence: BC042178
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000264888(uc003hjh.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL9:
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    SwitchGear 3'UTR luciferase reporter plasmidCXCL9 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CXCL9 (NM_002416)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL9
    Sirion Biotech Customized lentivirus for stable overexpression of CXCL9 
                         Customized lentivirus expression plasmids for stable overexpression of CXCL9 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL9

    Additional mRNA sequence: 

    AK311852.1 BC025745.1 BC042178.1 BC063122.1 BC095396.1 X72755.1 

    4 DOTS entries:

    DT.414759  DT.99955548  DT.95168680  DT.95168681 

    24/95 AceView cDNA sequences (see all 95):

    BQ016361 AI784420 AI918026 X72755 T89439 NM_002416 T29117 AA970872 
    BC042178 AI370217 AI924853 AI686870 AA131406 AA131506 AA974879 CB961971 
    AA865905 AA361362 AW514874 AI865101 BF438664 AI819546 BC025745 BF594047 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL9 expression in normal human tissues (normalized intensities)      CXCL9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CXCL9 Expression
    About this image


    CXCL9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
             alveolar macrophages   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             Lymphnode   
     
     Oral Cavity (Gastrointestinal Tract)
             Salivary gland   
     
     Lung (Respiratory System)
             alveolar macrophages   

    See CXCL9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL9

    SOURCE GeneReport for Unigene cluster: Hs.77367
        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL9 (see all 13): 
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Multiple Sclerosis in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CXCL9 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cxcl91 , 5 chemokine (C-X-C motif) ligand 91, 5 77.69(n)1
    71.9(a)1
      5 (46.51 cM)5
    173291  NM_008599.41  NP_032625.21 
     923213315 


    ENSEMBL Gene Tree for CXCL9 (if available)
    TreeFam Gene Tree for CXCL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL9 gene
    CXCL102  
    8 SIMAP similar genes for CXCL9 using alignment to 2 protein entries:     CXCL9_HUMAN (see all proteins):
    PPBP    CXCL3    CXCL2    CXCL1    CXCL10    CXCL11
    CXCL5    CXCL6

    CXCL9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/169 SNPs in CXCL9 are shown (see all 169)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859266611,2
    C--76922315(+) CAAATC/TCCTGA 1 -- ds50010--------
    rs1440120521,2
    C--76922338(+) CGCCCA/CCTTCG 1 -- ds50010--------
    rs1919801851,2
    C--76922355(+) CAAAGG/TGCTGG 1 -- ds50010--------
    rs1466320591,2
    C--76922412(+) AATCAA/GTGTTG 1 -- ds50010--------
    rs10501761,2
    C,F--76922749(-) ATATAC/TATACA 1 -- ut31 ese317Minor allele frequency- T:0.19MN NA WA CSA EA 994
    rs103371,2
    C,F--76922759(-) TTTATC/TATATA 1 -- ut3117Minor allele frequency- T:0.34MN NA WA EA 1300
    rs353246031,2
    C--76922817(-) CAGTAT/CATAAC 1 -- ut316Minor allele frequency- C:0.01MN NA 448
    rs344889311,2
    C,F--76922827(-) CACAGG/ATAGAC 1 -- ut315Minor allele frequency- A:0.01MN 400
    rs1839413741,2
    --76922840(+) ATGCAA/GGGTAA 1 -- ut310--------
    rs1450946051,2
    --76922928(+) GATTAG/TATAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CXCL9 (76922428 - 76928641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCL9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7363OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601704    OMIM disorders: --

    20/114 diseases for CXCL9 (see all 114):    About MalaCards
    lymphomatoid granulomatosis    sydenham's chorea    complex regional pain syndrome type 1    chronic eosinophilic pneumonia
    hypothyroidism, autoimmune    inclusion body myositis    eosinophilic pneumonia    severe acute respiratory syndrome
    melioidosis    radiculopathy    complex regional pain syndrome    proliferative glomerulonephritis
    chronic inflammatory demyelinating polyneuropathy    viral encephalitis    demyelinating polyneuropathy    mycosis fungoides
    keratitis    pulmonary sarcoidosis    interstitial lung disease    paracoccidioidomycosis

    2 diseases from the University of Copenhagen DISEASES database for CXCL9:
    Lung disease     Skin disease

    CXCL9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/59 Novoseek inferred disease relationships for CXCL9 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 58 18 15210824 (1), 17473147 (1), 19155971 (1), 19276231 (1) (see all 16)
    necrosis 48.5 36 9354680 (4), 9108380 (2), 19095263 (2), 20382085 (1) (see all 28)
    sporadic inclusion body myositis 48.5 2 12965263 (1)
    sarcoidosis pulmonary 42.2 2 17550373 (2)
    lymphomatoid granulomatosis 40.3 1 9354680 (1)
    immunopathology 39.7 1 16163626 (1)
    fibrosis idiopathic pulmonary 38.2 1 19565490 (1)
    keratoconjunctivitis vernal 36.8 1 14597036 (1)
    bronchoalveolar lavage fluid 36.6 3 18644457 (1), 15956791 (1), 17550373 (1)
    mycosis fungoides 36.5 1 15927812 (1)

    Genetic Association Database (GAD): CXCL9
    Human Genome Epidemiology (HuGE) Navigator: CXCL9 (11 documents)

    Export disorders for CXCL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL9 gene, integrated from 9 sources (see all 445):
    (articles sorted by number of sources associating them with CXCL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HuMig: a new human member of the chemokine family of cytokines. (PubMed id 8476424)1, 2, 3 Farber J.M. (1993)
    2. Association of cytokine and chemokine gene polymorphi sms with severe acute respiratory syndrome. (PubMed id 19258635)1, 4, 9 Lau Y.L. and Peiris J.S. (2009)
    3. Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PubMed id 10233762)1, 2, 9 Tensen C.P.... Willemze R. (1999)
    4. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    6. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    8. Polymorphisms of CXCR3-binding chemokines in type 1 diabetes. (PubMed id 19410617)1, 4 BrA1ck P....Ramos-Lopez E. (2009)
    9. Association of a CXCL9 polymorphism with pediatric Crohn's disease. (PubMed id 17892861)1, 4 Lacher M....Koletzko S. (2007)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4283 HGNC: 7098 AceView: CXCL9 Ensembl:ENSG00000138755 euGenes: HUgn4283
    ECgene: CXCL9 Kegg: 4283 H-InvDB: CXCL9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL9 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXCL9

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CXCL9 gene:
    Search GeneIP for patents involving CXCL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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