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Aliases for CXCL9 Gene

Aliases for CXCL9 Gene

  • C-X-C Motif Chemokine Ligand 9 2 3 5
  • Monokine Induced By Gamma Interferon 2 3
  • Monokine Induced By Interferon-Gamma 3 4
  • Gamma-Interferon-Induced Monokine 3 4
  • Chemokine (C-X-C Motif) Ligand 9 2 3
  • Small-Inducible Cytokine B9 3 4
  • Humig 3 4
  • SCYB9 3 4
  • CMK 3 4
  • MIG 3 4
  • C-X-C Motif Chemokine 9 3
  • Crg-10 3

External Ids for CXCL9 Gene

Previous HGNC Symbols for CXCL9 Gene

  • CMK
  • MIG

Previous GeneCards Identifiers for CXCL9 Gene

  • GC04M076818
  • GC04M077112
  • GC04M077315
  • GC04M077380
  • GC04M077279
  • GC04M076922
  • GC04M072674

Summaries for CXCL9 Gene

Entrez Gene Summary for CXCL9 Gene

  • This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]

GeneCards Summary for CXCL9 Gene

CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Sydenham Chorea and Endotheliitis. Among its related pathways are Peptide ligand-binding receptors and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. GO annotations related to this gene include cytokine activity and CXCR3 chemokine receptor binding. An important paralog of this gene is CXCL10.

UniProtKB/Swiss-Prot for CXCL9 Gene

  • Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.

Gene Wiki entry for CXCL9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL9 Gene

Genomics for CXCL9 Gene

Regulatory Elements for CXCL9 Gene

Enhancers for CXCL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G076027 1.7 FANTOM5 Ensembl ENCODE 27.4 -20.9 -20912 1.1 HNRNPUL1 HDGF PKNOX1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ART3 CXCL9 SDAD1 CXCL10 CXCL11 THAP6 NAAA GC04M075923 RPL36P8
GH04G076042 0.6 FANTOM5 72.9 -34.9 -34912 0.2 POLR2H JUND JUN JUNB FOS CXCL9 CXCL10 CXCL11 NAAA GC04P076101
GH04G076029 0.8 FANTOM5 46.9 -22.0 -21968 0.2 CTCF KLF1 ARID4B RBBP5 ZNF335 ZNF316 ZFHX2 ZNF366 EGR1 RELB CXCL9 CXCL10 CXCL11 SDAD1 ART3 NAAA GC04M075923 RPL36P8
GH04G076059 1.1 FANTOM5 ENCODE 29.6 -52.5 -52453 1.2 ATF1 NR2F1 ZNF175 ZNF384 ZBTB40 ZGPAT NCOR1 ZNF512 IKZF1 CREB1 ART3 CXCL10 CXCL9 NAAA CXCL11 SDAD1 LOC101928809 GC04P076101
GH04G076089 1.6 FANTOM5 Ensembl ENCODE 12.2 -82.8 -82809 2.1 PKNOX1 ATF1 ARNT BRCA1 TCF12 ZNF766 GATA2 FOS ZNF592 MEF2D NUP54 CXCL10 CXCL9 SDAD1 ART3 NAAA CXCL11 GC04P076101
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXCL9 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCL9 Gene

Chromosome:
4
Start:
76,001,275 bp from pter
End:
76,007,523 bp from pter
Size:
6,249 bases
Orientation:
Minus strand

Genomic View for CXCL9 Gene

Genes around CXCL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL9 Gene

Proteins for CXCL9 Gene

  • Protein details for CXCL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07325-CXCL9_HUMAN
    Recommended name:
    C-X-C motif chemokine 9
    Protein Accession:
    Q07325
    Secondary Accessions:
    • Q503B4

    Protein attributes for CXCL9 Gene

    Size:
    125 amino acids
    Molecular mass:
    14019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL9 Gene

Post-translational modifications for CXCL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Assay Products

  • Abcam assays for CXCL9

No data available for DME Specific Peptides for CXCL9 Gene

Domains & Families for CXCL9 Gene

Gene Families for CXCL9 Gene

Suggested Antigen Peptide Sequences for CXCL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07325

UniProtKB/Swiss-Prot:

CXCL9_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL9: view

Function for CXCL9 Gene

Molecular function for CXCL9 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells.

Gene Ontology (GO) - Molecular Function for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 2115167
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity IDA 12782716
GO:0048248 CXCR3 chemokine receptor binding IDA 12782716
genes like me logo Genes that share ontologies with CXCL9: view
genes like me logo Genes that share phenotypes with CXCL9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL9

CRISPR Products

miRNA for CXCL9 Gene

miRTarBase miRNAs that target CXCL9

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL9 Gene

Localization for CXCL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL9 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
cytoskeleton 1
mitochondrion 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,TAS --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CXCL9: view

Pathways & Interactions for CXCL9 Gene

genes like me logo Genes that share pathways with CXCL9: view

Gene Ontology (GO) - Biological Process for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006935 chemotaxis IDA 12782716
GO:0006952 defense response TAS 2115167
GO:0006954 inflammatory response TAS,IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with CXCL9: view

No data available for SIGNOR curated interactions for CXCL9 Gene

Drugs & Compounds for CXCL9 Gene

(19) Drugs for CXCL9 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adrenocorticotropic Hormone Pharma 164
beta-endorphin Pharma Full agonist, Agonist 140
Hormone Antagonists Pharma 13180
Hormones Pharma 14415
Hormones, Hormone Substitutes, and Hormone Antagonists Pharma 13168

(12) Additional Compounds for CXCL9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL9: view

Transcripts for CXCL9 Gene

mRNA/cDNA for CXCL9 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(95) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL9 Gene

Chemokine (C-X-C motif) ligand 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL9 Gene

No ASD Table

Relevant External Links for CXCL9 Gene

GeneLoc Exon Structure for
CXCL9
ECgene alternative splicing isoforms for
CXCL9

Expression for CXCL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL9 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL9 Gene

This gene is overexpressed in Lung (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of CXCL9 Gene:

CXCL9

SOURCE GeneReport for Unigene cluster for CXCL9 Gene:

Hs.77367

Evidence on tissue expression from TISSUES for CXCL9 Gene

  • Blood(4.6)
  • Skin(4.4)
  • Lymph node(3.5)
  • Spleen(2.9)
  • Intestine(2.6)
  • Lung(2.6)
  • Liver(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with CXCL9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL9 Gene

Orthologs for CXCL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL9 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia CXCL9 34 35
  • 78.76 (n)
mouse
(Mus musculus)
Mammalia Cxcl9 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CXCL9 35
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
OneToMany
Species where no ortholog for CXCL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL9 Gene

ENSEMBL:
Gene Tree for CXCL9 (if available)
TreeFam:
Gene Tree for CXCL9 (if available)

Paralogs for CXCL9 Gene

Paralogs for CXCL9 Gene

(8) SIMAP similar genes for CXCL9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CXCL9: view

Variants for CXCL9 Gene

Sequence variations from dbSNP and Humsavar for CXCL9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1001123018 -- 76,006,913(+) AGCAG(C/T)CAGAA intron-variant
rs1001781734 -- 76,006,563(+) ACCGT(A/G)AGTCC intron-variant
rs1002110613 -- 76,005,253(+) CATTG(G/T)CCAGG intron-variant, nc-transcript-variant
rs1002274101 -- 76,003,757(+) TTCCT(C/T)TTATT intron-variant
rs1002789859 -- 76,005,590(+) AATAA(C/T)CCTGG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL9 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER inversion 18451855

Variation tolerance for CXCL9 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL9 Gene

Disorders for CXCL9 Gene

MalaCards: The human disease database

(20) MalaCards diseases for CXCL9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sydenham chorea
  • saint vitus dance
endotheliitis
inclusion body myositis
  • distal myopathy with rimmed vacuoles
lymphomatoid granulomatosis
  • lyg
opsoclonus-myoclonus syndrome
  • infantile polymyoclonus
- elite association - COSMIC cancer census association via MalaCards
Search CXCL9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCL9

Genetic Association Database (GAD)
CXCL9
Human Genome Epidemiology (HuGE) Navigator
CXCL9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL9
genes like me logo Genes that share disorders with CXCL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL9 Gene

Publications for CXCL9 Gene

  1. HuMig: a new human member of the chemokine family of cytokines. (PMID: 8476424) Farber J.M. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 64
  2. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y. … Huang W. (J. Hum. Genet. 2010) 3 46 64
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
  5. Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathy. (PMID: 18413205) Higurashi M. … Yamada K. (J. Diabetes Complicat. 2009) 3 22 64

Products for CXCL9 Gene

Sources for CXCL9 Gene

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