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Aliases for CXCL8 Gene

Aliases for CXCL8 Gene

  • Chemokine (C-X-C Motif) Ligand 8 2 3 4
  • Monocyte-Derived Neutrophil Chemotactic Factor 2 3 4
  • Monocyte-Derived Neutrophil-Activating Peptide 2 3 4
  • Granulocyte Chemotactic Protein 1 2 3 4
  • IL8 3 4 6
  • Beta Endothelial Cell-Derived Neutrophil Activating Peptide 2 3
  • Lung Giant Cell Carcinoma-Derived Chemotactic Protein 2 3
  • Lymphocyte Derived Neutrophil Activating Peptide 2 3
  • Alveolar Macrophage Chemotactic Factor I 2 3
  • Tumor Necrosis Factor-Induced Gene 1 2 3
  • Neutrophil-Activating Peptide 1 2 3
  • T-Cell Chemotactic Factor 3 4
  • Interleukin 8 2 3
  • Emoctakin 3 4
  • GCP-1 3 4
  • MDNCF 3 4
  • MONAP 3 4
  • NAP-1 3 4
  • Small Inducible Cytokine Subfamily B, Member 8 3
  • Beta-Thromboglobulin-Like Protein 3
  • Neutrophil-Activating Protein 1 4
  • C-X-C Motif Chemokine 8 4
  • Interleukin-8 3
  • Protein 3-10C 4
  • LYNAP 3
  • NAP1 3
  • GCP1 3
  • LECT 3
  • LUCT 3
  • IL-8 4
  • NAF 3

External Ids for CXCL8 Gene

Previous HGNC Symbols for CXCL8 Gene

  • IL8

Summaries for CXCL8 Gene

Entrez Gene Summary for CXCL8 Gene

  • The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CXCL8 Gene

CXCL8 (Chemokine (C-X-C Motif) Ligand 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for CXCL8 Gene

  • IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Gene Wiki entry for CXCL8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL8 Gene

Genomics for CXCL8 Gene

Genomic Location for CXCL8 Gene

Start:
73,740,506 bp from pter
End:
73,743,716 bp from pter
Size:
3,211 bases
Orientation:
Plus strand

Genomic View for CXCL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL8 Gene

No data available for Regulatory Elements for CXCL8 Gene

Proteins for CXCL8 Gene

  • Protein details for CXCL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10145-IL8_HUMAN
    Recommended name:
    Interleukin-8
    Protein Accession:
    P10145
    Secondary Accessions:
    • B2R4L8
    • Q6FGF6
    • Q6LAE6
    • Q96RG6
    • Q9C077
    • Q9UCE1
    • Q9UCR8
    • Q9UCR9
    • Q9UCS0

    Protein attributes for CXCL8 Gene

    Size:
    99 amino acids
    Molecular mass:
    11098 Da
    Quaternary structure:
    • Homodimer

    Three dimensional structures from OCA and Proteopedia for CXCL8 Gene

    Alternative splice isoforms for CXCL8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXCL8 Gene

Proteomics data for CXCL8 Gene at MOPED

Post-translational modifications for CXCL8 Gene

  • Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
  • Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.

Other Protein References for CXCL8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL8 Gene

Domains for CXCL8 Gene

Gene Families for CXCL8 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • IL :Interleukins and interleukin receptors

Protein Domains for CXCL8 Gene

Graphical View of Domain Structure for InterPro Entry

P10145

UniProtKB/Swiss-Prot:

IL8_HUMAN :
  • P10145
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL8: view

No data available for Suggested Antigen Peptide Sequences for CXCL8 Gene

Function for CXCL8 Gene

Molecular function for CXCL8 Gene

UniProtKB/Swiss-Prot Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
UniProtKB/Swiss-Prot Induction: By ER stress in a DDIT3/CHOP-dependent manner.

Gene Ontology (GO) - Molecular Function for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005153 interleukin-8 receptor binding IPI 1840701
GO:0005515 protein binding IPI 10880251
GO:0008009 chemokine activity TAS 12782716
genes like me logo Genes that share ontologies with CXCL8: view
genes like me logo Genes that share phenotypes with CXCL8: view

Animal Models for CXCL8 Gene

MGI Knock Outs for CXCL8:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CXCL8 Gene

Localization for CXCL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL8 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CXCL8: view

No data available for Subcellular locations from COMPARTMENTS for CXCL8 Gene

Pathways for CXCL8 Gene

genes like me logo Genes that share pathways with CXCL8: view

Gene Ontology (GO) - Biological Process for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 11483765
GO:0002237 response to molecule of bacterial origin IDA 19912257
GO:0006928 movement of cell or subcellular component TAS 10820279
GO:0006935 chemotaxis TAS 12782716
GO:0006954 inflammatory response TAS 11483765
genes like me logo Genes that share ontologies with CXCL8: view

Compounds for CXCL8 Gene

(138) Novoseek inferred chemical compound relationships for CXCL8 Gene

Compound -log(P) Hits PubMed IDs
rantes 92.7 376
groalpha 86.1 151
fmlp 79.7 232
leukotriene b4 78.5 240
vegf 76.4 430
genes like me logo Genes that share compounds with CXCL8: view

Transcripts for CXCL8 Gene

mRNA/cDNA for CXCL8 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1:
SP2: -
SP3:

Relevant External Links for CXCL8 Gene

GeneLoc Exon Structure for
CXCL8
ECgene alternative splicing isoforms for
CXCL8

Expression for CXCL8 Gene

mRNA expression in normal human tissues for CXCL8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CXCL8 Gene

genes like me logo Genes that share expressions with CXCL8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CXCL8 Gene

Orthologs for CXCL8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL8 35
  • 99.33 (n)
  • 100 (a)
IL8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL-8 36
  • 76 (a)
OneToOne
IL8 35
  • 83.51 (n)
  • 79.38 (a)
dog
(Canis familiaris)
Mammalia IL8 35
  • 81.44 (n)
  • 77.32 (a)
IL8 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl3 36
  • 37 (a)
ManyToMany
Il8 16
oppossum
(Monodelphis domestica)
Mammalia IL8 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL8 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL8 36
  • 48 (a)
OneToMany
K60 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia IL8 36
  • 40 (a)
OneToOne
Species with no ortholog for CXCL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL8 Gene

ENSEMBL:
Gene Tree for CXCL8 (if available)
TreeFam:
Gene Tree for CXCL8 (if available)

Paralogs for CXCL8 Gene

Paralogs for CXCL8 Gene

genes like me logo Genes that share paralogs with CXCL8: view

Variants for CXCL8 Gene

Sequence variations from dbSNP and Humsavar for CXCL8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4073 -- 73,740,307(+) ATACA(A/T)TTGAT upstream-variant-2KB
rs12420 -- 73,742,696(+) CAAAA(A/T)ACAAC utr-variant-3-prime
rs1126647 -- 73,743,328(+) AGATA(A/T)ACAAC utr-variant-3-prime
rs1803205 -- 73,740,676(+) CTGGC(C/T)GTGGC reference, synonymous-codon
rs2227306 -- 73,741,338(+) GAAGT(C/T)GTTCA intron-variant

Relevant External Links for CXCL8 Gene

HapMap Linkage Disequilibrium report
CXCL8
Human Gene Mutation Database (HGMD)
CXCL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CXCL8 Gene

Disorders for CXCL8 Gene

(98) Novoseek inferred disease relationships for CXCL8 Gene

Disease -log(P) Hits PubMed IDs
necrosis 91.7 243
inflammation 90.2 194
tumors 81.8 313
bronchoalveolar lavage fluid 72.9 122
systemic inflammatory response syndrome 70.3 25
genes like me logo Genes that share disorders with CXCL8: view

No data available for UniProtKB/Swiss-Prot for CXCL8 Gene

Publications for CXCL8 Gene

  1. Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO- alpha and leaves RANTES and MCP-2 intact. (PMID: 11023497) Van den Steen P.E. … Opdenakker G. (Blood 2000) 3 4 23
  2. Structure and activity of a chimeric interleukin-8-melanoma-growth- stimulatory-activity protein. (PMID: 8631339) Sticht H. … Rosch P. (Eur. J. Biochem. 1996) 3 4 23
  3. Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells. (PMID: 11784713) Lee T.H. … Avraham S. (J. Biol. Chem. 2002) 3 23
  4. Signals involved in mycobacteria-induced CXCL-8 production by human monocytes. (PMID: 11911801) MAcndez-Samperio P. … VA!zquez A. (J. Interferon Cytokine Res. 2002) 3 23
  5. Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions. (PMID: 11964077) Davidson B. … Goldberg I. (Clin. Exp. Metastasis 2002) 3 23

Products for CXCL8 Gene

  • Addgene plasmids for CXCL8

Sources for CXCL8 Gene

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