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CXCL8 Gene(Protein Coding)

C-X-C Motif Chemokine Ligand 8

GCID:
GC04P073740
GIFtS:
57
Genes Participants
UDN Logo

Aliases for CXCL8 Gene

Aliases for CXCL8 Gene

  • C-X-C Motif Chemokine Ligand 8 2 3 5
  • Monocyte-Derived Neutrophil Chemotactic Factor 2 3 4
  • Monocyte-Derived Neutrophil-Activating Peptide 2 3 4
  • Granulocyte Chemotactic Protein 1 2 3 4
  • Chemokine (C-X-C Motif) Ligand 8 2 3 4
  • Beta Endothelial Cell-Derived Neutrophil Activating Peptide 2 3
  • Lung Giant Cell Carcinoma-Derived Chemotactic Protein 2 3
  • Lymphocyte Derived Neutrophil Activating Peptide 2 3
  • Alveolar Macrophage Chemotactic Factor I 2 3
  • Tumor Necrosis Factor-Induced Gene 1 2 3
  • Neutrophil-Activating Peptide 1 2 3
  • T-Cell Chemotactic Factor 3 4
  • Interleukin 8 2 3
  • Emoctakin 3 4
  • GCP-1 3 4
  • MDNCF 3 4
  • MONAP 3 4
  • NAP-1 3 4
  • IL8 3 4
  • Small Inducible Cytokine Subfamily B, Member 8 3
  • Beta-Thromboglobulin-Like Protein 3
  • Neutrophil-Activating Protein 1 4
  • C-X-C Motif Chemokine 8 4
  • Interleukin-8 3
  • Protein 3-10C 4
  • LYNAP 3
  • NAP1 3
  • GCP1 3
  • LECT 3
  • LUCT 3
  • IL-8 4
  • NAF 3

External Ids for CXCL8 Gene

Previous HGNC Symbols for CXCL8 Gene

  • IL8

Summaries for CXCL8 Gene

Entrez Gene Summary for CXCL8 Gene

  • The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CXCL8 Gene

CXCL8 (C-X-C Motif Chemokine Ligand 8) is a Protein Coding gene. Diseases associated with CXCL8 include Bronchiolitis and Extrinsic Allergic Alveolitis. Among its related pathways are Bacterial infections in CF airways and Peptide ligand-binding receptors. GO annotations related to this gene include chemokine activity and interleukin-8 receptor binding. An important paralog of this gene is CXCL2.

UniProtKB/Swiss-Prot for CXCL8 Gene

  • IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Gene Wiki entry for CXCL8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL8 Gene

Genomics for CXCL8 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CXCL8 Gene

Enhancers for CXCL8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G073702 2 FANTOM5 Ensembl ENCODE dbSUPER 66.4 -35.8 -35808 3.8 PKNOX1 CREB3L1 ARNT SIN3A FEZF1 YY1 ZNF766 FOS KLF13 REST CXCL8 CXCL2 CXCL3 PF4V1 LOC105377272 CXCL5 MTHFD2L CXCL1 ANKRD17 RASSF6
GH04G073730 1.9 FANTOM5 Ensembl ENCODE dbSUPER 55.2 -7.1 -7097 5.2 HDAC1 PKNOX1 ATF1 TBL1XR1 BMI1 ZBTB40 ZNF766 CBX5 FOS RELB CXCL8 CXCL2 CXCL3 PF4V1 MTHFD2L ANKRD17 CXCL1 LOC105377272
GH04G073718 1.4 FANTOM5 Ensembl dbSUPER 53.7 -21.6 -21606 0.6 BACH1 BMI1 CEBPG ZNF316 ARID3A NFE2 ETV6 RELB IKZF2 CREM CXCL8 CXCL3 CXCL2 MTHFD2L PF4V1 ANKRD17 LOC105377272
GH04G073725 1.6 FANTOM5 Ensembl ENCODE dbSUPER 46.6 -14.2 -14207 2.0 JUN CEBPB EP300 FOSL1 JUND ZNF366 GATA2 IKZF1 ZNF512 NFE2 CXCL2 CXCL8 CXCL3 MTHFD2L PF4V1 LOC105377272
GH04G073660 1.6 FANTOM5 Ensembl ENCODE dbSUPER 43.3 -78.1 -78110 3.3 CTCF ATF1 JUN RAD21 YY1 FOSL1 ZNF664 GATA2 SMC3 FOS CXCL3 CXCL2 CXCL8 RASSF6 MTHFD2L PF4V1 LOC105377272
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXCL8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCL8 Gene

Chromosome:
4
Start:
73,740,506 bp from pter
End:
73,743,716 bp from pter
Size:
3,211 bases
Orientation:
Plus strand

Genomic View for CXCL8 Gene

Genes around CXCL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CXCL8 Gene

Proteins for CXCL8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CXCL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10145-IL8_HUMAN
    Recommended name:
    Interleukin-8
    Protein Accession:
    P10145
    Secondary Accessions:
    • B2R4L8
    • Q6FGF6
    • Q6LAE6
    • Q96RG6
    • Q9C077
    • Q9UCE1
    • Q9UCR8
    • Q9UCR9
    • Q9UCS0

    Protein attributes for CXCL8 Gene

    Size:
    99 amino acids
    Molecular mass:
    11098 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAK00048.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXCL8 Gene

neXtProt entry for CXCL8 Gene

Protein Expression for CXCL8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CXCL8 Gene

  • Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
  • Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.

Other Protein References for CXCL8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL8 Gene

Domains & Families for CXCL8 Gene

Gene Families for CXCL8 Gene

HGNC:

Protein Domains for CXCL8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10145

UniProtKB/Swiss-Prot:

IL8_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL8: view

Function for CXCL8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CXCL8 Gene

UniProtKB/Swiss-Prot Function:
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
UniProtKB/Swiss-Prot Induction:
By ER stress in a DDIT3/CHOP-dependent manner.

Gene Ontology (GO) - Molecular Function for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005153 interleukin-8 receptor binding IPI,IEA 1840701
GO:0005515 protein binding IPI 10880251
GO:0008009 chemokine activity TAS,IEA 12782716
genes like me logo Genes that share ontologies with CXCL8: view
genes like me logo Genes that share phenotypes with CXCL8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CXCL8

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CXCL8 Gene

Localization for CXCL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL8 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 2

Gene Ontology (GO) - Cellular Components for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with CXCL8: view

Pathways & Interactions for CXCL8 Gene

genes like me logo Genes that share pathways with CXCL8: view

SIGNOR curated interactions for CXCL8 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 11483765
GO:0002237 response to molecule of bacterial origin IDA 19912257
GO:0006928 movement of cell or subcellular component TAS 10820279
GO:0006935 chemotaxis IEA,TAS 12782716
GO:0006952 defense response IEA --
genes like me logo Genes that share ontologies with CXCL8: view

Drugs & Compounds for CXCL8 Gene

Products:

  1. Drug

(75) Drugs for CXCL8 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 519
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 2020
Sunitinib Approved, Investigational Pharma VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors, Potent VEGFR, PDGFRbeta and KIT inhibitor 510
Salbutamol Approved, Vet_approved Pharma Partial agonist, Agonist 0
ABT-510 Investigational Pharma Target 0

(69) Additional Compounds for CXCL8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL8: view

Transcripts for CXCL8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CXCL8 Gene

(1) REFSEQ mRNAs :
(756) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CXCL8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1:
SP2: -
SP3:

Relevant External Links for CXCL8 Gene

GeneLoc Exon Structure for
CXCL8
ECgene alternative splicing isoforms for
CXCL8

Expression for CXCL8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL8 Gene

mRNA expression in normal human tissues for CXCL8 Gene
mRNA expression by GTEx for CXCL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CXCL8 Gene

This gene is overexpressed in Amniocyte (56.1) and Islet of Langerhans (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL8 Gene



Protein tissue co-expression partners for CXCL8 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL8 Gene:

CXCL8

Evidence on tissue expression from TISSUES for CXCL8 Gene

  • Blood(5)
  • Lung(4.9)
  • Skin(4.6)
  • Kidney(4.5)
  • Pancreas(4.2)
  • Nervous system(4)
  • Bone marrow(3.8)
  • Intestine(3.8)
  • Heart(3.2)
  • Liver(3.1)
  • Stomach(3)
  • Spleen(2.9)
  • Lymph node(2.8)
  • Muscle(2.4)
  • Eye(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with CXCL8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL8 Gene

Orthologs for CXCL8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IL8 34 35
  • 99.33 (n)
cow
(Bos Taurus)
 Mammalia IL8 34
  • 83.51 (n)
IL-8 35
  • 76 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia IL8 34 35
  • 81.44 (n)
oppossum
(Monodelphis domestica)
 Mammalia IL8 35
  • 75 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia IL8 35
  • 41 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cxcl3 35
  • 37 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves IL8 35
  • 48 (a)
 OneToMany
K60 35
  • 46 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia IL8 35
  • 40 (a)
 OneToOne
Species where no ortholog for CXCL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL8 Gene

ENSEMBL:
Gene Tree for CXCL8 (if available)
TreeFam:
Gene Tree for CXCL8 (if available)

Paralogs for CXCL8 Gene

Paralogs for CXCL8 Gene

genes like me logo Genes that share paralogs with CXCL8: view

Variants for CXCL8 Gene

Sequence variations from dbSNP and Humsavar for CXCL8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000003014 -- 73,739,370(+) ACAGA(A/T)TCCAA upstream-variant-2KB
rs1000022557 -- 73,743,126(+) ATTTA(A/T)GTATT utr-variant-3-prime
rs1000275946 -- 73,739,885(+) GACCA(A/G)ACTCT upstream-variant-2KB
rs1000557302 -- 73,740,928(+) TAGAT(A/T)TTCTG intron-variant
rs1000965738 -- 73,740,637(+) GAAGG(A/G)ACCAT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CXCL8 Gene

Variant ID Type Subtype PubMed ID
nsv1001725 CNV gain 25217958

Variation tolerance for CXCL8 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL8 Gene

Human Gene Mutation Database (HGMD)
CXCL8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL8 Gene

Disorders for CXCL8 Gene

MalaCards: The human disease database

(213) MalaCards diseases for CXCL8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bronchiolitis
extrinsic allergic alveolitis
  • alveolitis
lung giant cell carcinoma
  • giant cell carcinoma
bronchiolitis obliterans
  • bronchiolitis exudativa
adult respiratory distress syndrome
  • adult rds
- elite association - COSMIC cancer census association via MalaCards
Search CXCL8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCL8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL8
genes like me logo Genes that share disorders with CXCL8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL8 Gene

Publications for CXCL8 Gene

  1. IL-8 production by macrophages is synergistically enhanced when cigarette smoke is combined with TNF-alpha. (PMID: 19874800) Sarir H. … Folkerts G. (Biochem. Pharmacol. 2010) 3 22 64
  2. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. (PMID: 20026745) Reeves E.P. … McElvaney N.G. (J. Immunol. 2010) 3 22 64
  3. Neutrophil expression of cyclooxygenase 2 in preeclampsia. (PMID: 20220108) Bachawaty T. … Walsh S.W. (Reprod Sci 2010) 3 22 64
  4. Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis. (PMID: 20194723) Kim G.Y. … Kim J.H. (J. Immunol. 2010) 3 22 64
  5. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. (PMID: 19597126) Al Alam D. … Gangloff S.C. (Am. J. Respir. Cell Mol. Biol. 2010) 3 22 64

Products for CXCL8 Gene

  • Addgene plasmids for CXCL8

Sources for CXCL8 Gene

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