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CXCL6 Gene

protein-coding   GIFtS: 57
GCID: GC04P074691

Chemokine (C-X-C Motif) Ligand 6

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbol: SCYB6)
  See CXCL6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-X-C Motif) Ligand 61 2     Chemokine Alpha 32 3
SCYB61 2 3 5     Small-Inducible Cytokine B62 3
Granulocyte Chemotactic Protein 21 2 3     CKA-32 3
GCP22 3 5     GCP-22 3
Chemokine (C-X-C Motif) Ligand 6 (Granulocyte Chemotactic Protein 2)1 2     C-X-C Motif Chemokine 62
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 6 (Granulocyte
Chemotactic Protein 2)1 2
     Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member B2

External Ids:    HGNC: 106431   Entrez Gene: 63722   Ensembl: ENSG000001248757   OMIM: 1389655   UniProtKB: P801623   
ORGUL members:         

Export aliases for CXCL6 gene to outside databases

Previous GC identifers: GC04P074942 GC04P075102 GC04P075168 GC04P075067 GC04P074921 GC04P070513


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CXCL6 Gene:
CXCL6 (chemokine (C-X-C motif) ligand 6) is a protein-coding gene. Diseases associated with CXCL6 include periodontal disease, and wegener's granulomatosis. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162
Function: Chemotactic for neutrophil granulocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL6 gene promoter:
         SRF   RFX1   Pbx1a   MEF-2   SRF (504 AA)   Lmo2   AP-4   MEF-2A   aMEF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL6 promoter sequence
   Search Chromatin IP Primers for CXCL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

CXCL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074691:  view genomic region     (about GC identifiers)

Start:
74,702,214 bp from pter      End:
74,714,781 bp from pter
Size:
12,568 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162 (See protein sequence)
Recommended Name: C-X-C motif chemokine 6 precursor  
Size: 114 amino acids; 11897 Da
Secondary accessions: B2R4X3 Q4W5D4

Explore the universe of human proteins at neXtProt for CXCL6: NX_P80162

Explore proteomics data for CXCL6 at MOPED


See CXCL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002984.1  
ENSEMBL proteins: 
 ENSP00000226317   ENSP00000424819  
Reactome Protein details: P80162

CXCL6 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CXCL6 (CXCL6/GCP-2)
Browse recombinant and purified proteins available from Enzo Life Sciences
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OriGene Protein Over-expression Lysate for CXCL6
OriGene Custom MassSpec
OriGene Custom Protein Services for CXCL6
GenScript Custom Purified and Recombinant Proteins Services for CXCL6
Novus Biologicals CXCL6 Proteins
Novus Biologicals CXCL6 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for CXCL6 

 
antibodies-online proteins for CXCL6 (3 products) 

 
antibodies-online peptides for CXCL6

CXCL6 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CXCL6 (CXCL6/GCP-2)
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OriGene Custom Antibody Services for CXCL6
Novus Biologicals CXCL6 Antibodies
Abcam antibodies for CXCL6
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for CXCL6
antibodies-online antibodies for CXCL6 (15 products) 

CXCL6 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CXCL6
R&D Systems ELISAs for CXCL6 (CXCL6/GCP-2)
GenScript Custom Assay Services for CXCL6
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for CXCL6 
antibodies-online kits for CXCL6 (9 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR001811 Chemokine_IL8-like_dom
 IPR001089 Chemokine_CXC
 IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry P80162

ProtoNet protein and cluster: P80162

1 Blocks protein domain: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162
Similarity: Belongs to the intercrine alpha (chemokine CxC) family


Find genes that share domains with CXCL6           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CXCL6_HUMAN, P80162
Function: Chemotactic for neutrophil granulocytes

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008009chemokine activity IEA--
GO:0008201heparin binding IEA--
     
Find genes that share ontologies with CXCL6           About GenesLikeMe


Phenotypes:
     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cxcl5):
 hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

Find genes that share phenotypes with CXCL6           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Cxcl5tm1Gscw for CXCL6

   genOway: Develop your customized and physiologically relevant rodent model for CXCL6

miRNA
Products:
    
miRTarBase miRNAs that target CXCL6:
hsa-mir-26b-5p (MIRT029714)

Block miRNA regulation of human, mouse, rat CXCL6 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CXCL6 (see all 9):
hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*
SwitchGear 3'UTR luciferase reporter plasmidCXCL6 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CXCL6
Predesigned siRNA for gene silencing in human, mouse, rat CXCL6

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CXCL6

Clone
Products:
     
OriGene clones in human, mouse for CXCL6 (see all 6)
OriGene ORF clones in mouse, rat for CXCL6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
Sino Biological Human cDNA Clone for CXCL6
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CXCL6
Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL6 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CXCL6_HUMAN, P80162: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytoskeleton1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

Find genes that share ontologies with CXCL6           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CXCL6 About   (see all 12)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
IL-6 Pathway0.61
MIF Mediated Glucocorticoid Regulation0.94
STAT3 Pathway0.47
PEDF Induced Signaling0.73
Endothelin-1 Signaling Pathway0.46
all-trans-Retinoic Acid Signaling in Brain0.71
Cytokine-cytokine receptor interaction0.43
2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine receptors bind chemokines0.81
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
3Chemokine Signaling
Chemokine signaling pathway0.33
Chemokine Signaling0.33
4Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.44
5Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90


Find genes that share SuperPaths with CXCL6           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CXCL6
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL6 (see all 17)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Transendothelial Migration of Leukocytes
MIF Mediated Glucocorticoid Regulation

2 GeneGo (Thomson Reuters) Pathways for CXCL6
    Cytokine production by Th17 cells in CF (Mouse model)
Cytokine production by Th17 cells in CF


2 Reactome Pathways for CXCL6
    Chemokine receptors bind chemokines
G alpha (i) signalling events


4 Kegg Pathways  (Kegg details for CXCL6):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Pertussis
Rheumatoid arthritis

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL6 (see all 9): 
          Angiogenic Growth Factors in human mouse rat
          Wound Healing in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Angiogenesis in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CXCL6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CXCL6 (P801623 ENSP000002263174) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
InteractantInteraction Details
GeneCardExternal ID(s)
CXCR2P250253, ENSP000003196354I2D: score=2 STRING: ENSP00000319635
MMP9P147803, ENSP000003614054I2D: score=2 STRING: ENSP00000361405
CXCR1P250243, ENSP000002956834I2D: score=2 STRING: ENSP00000295683
MMP1P039563I2D: score=1 
MMP12P399003I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis TAS9164944
GO:0006954inflammatory response TAS8399143
GO:0006955immune response IEA--
GO:0007165signal transduction TAS9164944
GO:0007267cell-cell signaling TAS9164944

Find genes that share ontologies with CXCL6           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CXCL6

8 Novoseek inferred chemical compound relationships for CXCL6 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
grogamma 88.9 4 15832427 (2), 9054580 (1), 19594487 (1)
grobeta 87.8 9 15292528 (3), 15832427 (2), 19594487 (1)
groalpha 85.5 10 10540194 (2), 18174342 (2), 9054580 (1), 9365109 (1) (see all 6)
rantes 55.2 8 9516414 (3), 14707104 (2), 8805659 (1), 18290317 (1) (see all 5)
calcium 12.6 10 9057843 (1), 10570306 (1), 15476666 (1), 17699811 (1) (see all 8)
vegf 4.51 5 16332507 (3), 16377203 (1), 18290317 (1)
oxygen 0 1 16721367 (1)
serine 0 1 9516414 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CXCL6 gene: 
NM_002993.3  

Unigene Cluster for CXCL6:

Chemokine (C-X-C motif) ligand 6
Hs.164021  [show with all ESTs]
Unigene Representative Sequence: NM_002993
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000226317(uc003hhf.3) ENST00000515050 ENST00000503446
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CXCL6 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CXCL6 (see all 9):
hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*
SwitchGear 3'UTR luciferase reporter plasmidCXCL6 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CXCL6
Predesigned siRNA for gene silencing in human, mouse, rat CXCL6
Clone
Products:
     
OriGene clones in human, mouse for CXCL6 (see all 6)
OriGene ORF clones in mouse, rat for CXCL6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CXCL6
OriGene qSTAR qPCR primer pairs in human, mouse for CXCL6
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL6
  QuantiTect SYBR Green Assays in human, mouse, rat CXCL6
  QuantiFast Probe-based Assays in human, mouse, rat CXCL6

Additional mRNA sequence: 

AK311981.1 BC013744.1 U81234.1 Y08770.1 

2 DOTS entries:

DT.70104493  DT.121258772 

59 AceView cDNA sequences (see top 24):

AU102795 CR614096 CB112103 BP338870 BM994397 AU098540 BQ717848 BP336724 
CR623302 AW515797 AU076718 BX380732 CA420646 CB853166 BQ694209 BU942618 
BP337169 BC013744 BG253033 BP336399 BG122200 BP335241 BX395981 AI668847 
U81234 BU677384 BG252203 BP335944 BG122844 BP335443 BP337673 BM981549 
CA416348 AI391519 AI860457 BI837587 BI837528 BI768679 BM995310 BP339410 
BP336358 BI819952 CB147271 NM_002993 BP336421 CB529862 BP337255 BG120266 
BP340202 AI889554 BP337573 BP336245 BP339092 BP335298 BP337635 BP336009 
AW191857 BQ893979 BG119025 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXCL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGGTTTTTG
CXCL6 Expression
About this image


CXCL6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
         PureStem 4D20.8, NCr-fac Progenitor
 
 Liver (Hepatobiliary System)
         Liver Lobule
 
 Mesoderm (Gastrulation Derivatives)
         PureStem 7SMOO32, NCr-fac & Meso Progenitor
 
 Heart (Cardiovascular System)
         Mature Cardiac Fibroblasts Myocardium
 
 Paraxial Mesoderm (Gastrulation Derivatives)
         PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
CXCL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CXCL6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.164021
    Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL6 (see all 9): 
          Angiogenic Growth Factors in human mouse rat
          Wound Healing in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Angiogenesis in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CXCL6
OriGene qSTAR qPCR primer pairs in human, mouse for CXCL6
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL6
QuantiTect SYBR Green Assays in human, mouse, rat CXCL6
QuantiFast Probe-based Assays in human, mouse, rat CXCL6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CXCL6 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cxcl51 , 5 chemokine (C-X-C motif) ligand 51, 5 71.43(n)1
64.94(a)1
  5 (44.78 cM)5
203111  NM_009141.31  NP_033167.21 
 907592995 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
33(a)
1 → many
4(50379773-50381069)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
37(a)
1 → many
6(60123888-60134622)


ENSEMBL Gene Tree for CXCL6 (if available)
TreeFam Gene Tree for CXCL6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CXCL6 gene
PPBP2  PF42  CXCL12  PF4V12  CXCL32  CXCL52  CXCL22  IL82  
12 SIMAP similar genes for CXCL6 using alignment to 2 protein entries:     CXCL6_HUMAN (see all proteins):
CXCL5    IL8    CXCL3    CXCL1    CXCL2    PF4
CXCL10    CXCL12    CXCL9    PF4V1    PPBP    CXCL13

Find genes that share paralogs with CXCL6           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CXCL6 (see all 125)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs76884851,2
C,A--74700367(+) aacatA/Tcgtgt 1 -- us2k11Minor allele frequency- T:0.00NA 2
rs1119035791,2
C--74700432(+) TGGGAC/TGGCTG 1 -- us2k10--------
rs1923228371,2
--74700445(+) TCAAAC/TGGTAT 1 -- us2k10--------
rs1814719331,2
--74700465(+) TAGATA/CCCTGA 1 -- us2k10--------
rs623124151,2
C--74700530(+) AGTGTC/AAAAGT 1 -- us2k11Minor allele frequency- A:0.00NA 2
rs361919221,2
C--74700541(+) GTTCCT/CATTTC 1 -- us2k11Minor allele frequency- C:0.00NA 2
rs1870626131,2
--74700733(+) CATCCA/GCTTTT 1 -- us2k10--------
rs1910511871,2
--74700736(+) CCACTA/TTTTGA 1 -- us2k10--------
rs1828083321,2
C--74700761(+) TTTTTC/GTTGTA 1 -- us2k10--------
rs119309781,2
C,A,H--74700826(+) ggtcgT/Cgaaaa 1 -- us2k1 tfbs31Minor allele frequency- C:0.00NA 2

HapMap Linkage Disequilibrium report for CXCL6 (74702214 - 74714781 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CXCL6:    About this table    
Variant IDTypeSubtypePubMed ID
nsv4389CNV Insertion18451855

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CXCL6
DNA2.0 Custom Variant and Variant Library Synthesis for CXCL6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 138965    OMIM disorders: --

2 diseases for CXCL6:    
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periodontal disease    wegener's granulomatosis


Find genes that share disorders with CXCL6           About GenesLikeMe

Selected Novoseek inferred disease relationships for CXCL6 gene (see all 16)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 43.8 9 18842116 (2), 18782286 (1), 16305697 (1), 18443119 (1) (see all 6)
osteosarcoma 40.6 8 9057843 (2), 9054580 (1), 9164944 (1), 9365109 (1) (see all 5)
tonsillitis 38.8 4 15807854 (3)
necrosis 19.3 2 12882792 (1), 12524079 (1)
sinusitis 18.8 1 12744776 (1)
pathological processes 12.7 3 12524079 (1), 12533683 (1)
tumors 12.6 21 11583968 (4), 15652347 (2), 18578857 (2), 9057843 (1) (see all 10)
neovascularization 9.79 1 15652347 (1)
osteoarthritis 6.82 7 15292528 (3), 14707104 (1)
asthma 0 1 16332507 (1)

Genetic Association Database (GAD): CXCL6
Human Genome Epidemiology (HuGE) Navigator: CXCL6 (7 documents)

Export disorders for CXCL6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CXCL6 gene, integrated from 10 sources (see all 116):
(articles sorted by number of sources associating them with CXCL6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell- derived neutrophil activating peptide-78 mRNAs. (PubMed id 9057843)1, 2, 9 Froyen G.... Billiau A. (Eur. J. Biochem. 1997)
  2. Cloning and characterization of the human granulocyte chemotactic protein-2 gene. (PubMed id 9164944)1, 2, 9 Rovai L.E.... Smith J.B. (J. Immunol. 1997)
  3. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)1, 2, 9 Proost P....van Damme J. (J. Immunol. 1993)
  4. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. (PubMed id 8399143)1, 2, 9 Proost P.... van Damme J. (Biochemistry 1993)
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
  7. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
  8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  9. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)1, 4 Hillian A.D....Drumm M.L. (Genes Immun. 2008)
  10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6372 HGNC: 10643 AceView: CXCL6 Ensembl:ENSG00000124875 euGenes: HUgn6372
ECgene: CXCL6 Kegg: 6372 H-InvDB: CXCL6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CXCL6 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/CXCL6

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CXCL6 gene:
Search GeneIP for patents involving CXCL6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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