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CXCL6 Gene

protein-coding   GIFtS: 57
GCID: GC04P074691

Chemokine (C-X-C Motif) Ligand 6

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbol: SCYB6)
  See CXCL6-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Chemokine (C-X-C Motif) Ligand 61 2     Chemokine Alpha 32 3
SCYB61 2 3 5     Small-Inducible Cytokine B62 3
Granulocyte Chemotactic Protein 21 2 3     CKA-32 3
GCP22 3 5     GCP-22 3
Chemokine (C-X-C Motif) Ligand 6 (Granulocyte Chemotactic Protein 2)1 2     C-X-C Motif Chemokine 62
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 6 (Granulocyte
Chemotactic Protein 2)1 2
     Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member B2

External Ids:    HGNC: 106431   Entrez Gene: 63722   Ensembl: ENSG000001248757   OMIM: 1389655   UniProtKB: P801623   
ORGUL members:         

Export aliases for CXCL6 gene to outside databases

Previous GC identifers: GC04P074942 GC04P075102 GC04P075168 GC04P075067 GC04P074921 GC04P070513

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CXCL6 Gene:
CXCL6 (chemokine (C-X-C motif) ligand 6) is a protein-coding gene. Diseases associated with CXCL6 include wegener's granulomatosis, and periodontal disease. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162
Function: Chemotactic for neutrophil granulocytes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL6 gene promoter:
         SRF   RFX1   Pbx1a   MEF-2   SRF (504 AA)   Lmo2   AP-4   MEF-2A   aMEF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL6 promoter sequence
   Search Chromatin IP Primers for CXCL6

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

CXCL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074691:  view genomic region     (about GC identifiers)

74,702,214 bp from pter      End:
74,714,781 bp from pter
12,568 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162 (See protein sequence)
Recommended Name: C-X-C motif chemokine 6 precursor  
Size: 114 amino acids; 11897 Da
Secondary accessions: B2R4X3 Q4W5D4

Explore the universe of human proteins at neXtProt for CXCL6: NX_P80162

Explore proteomics data for CXCL6 at MOPED

See CXCL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002984.1  
ENSEMBL proteins: 
 ENSP00000226317   ENSP00000424819  
Reactome Protein details: P80162

CXCL6 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CXCL6 (CXCL6/GCP-2)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for CXCL6
OriGene Custom MassSpec
OriGene Custom Protein Services for CXCL6
GenScript Custom Purified and Recombinant Proteins Services for CXCL6
Novus Biologicals CXCL6 Proteins
Novus Biologicals CXCL6 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

Search eBioscience for Proteins for CXCL6 

GeneTex Proteins for CXCL6:  
                    GCP-2 Recombinant Protein (Active) (GTX48141-PRO)

antibodies-online proteins for CXCL6 (3 products) 

antibodies-online peptides for CXCL6

CXCL6 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CXCL6 (CXCL6/GCP-2)
Browse OriGene Antibodies
OriGene Custom Antibody Services for CXCL6
Novus Biologicals CXCL6 Antibodies
Abcam antibodies for CXCL6
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for CXCL6
antibodies-online antibodies for CXCL6 (15 products) 

CXCL6 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CXCL6
R&D Systems ELISAs for CXCL6 (CXCL6/GCP-2)
GenScript Custom Assay Services for CXCL6
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for CXCL6 
antibodies-online kits for CXCL6 (9 products) 

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR001811 Chemokine_IL8-like_dom
 IPR001089 Chemokine_CXC
 IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry P80162

ProtoNet protein and cluster: P80162

1 Blocks protein domain: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162
Similarity: Belongs to the intercrine alpha (chemokine CxC) family

Find genes that share domains with CXCL6           About GenesLikeMe

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CXCL6_HUMAN, P80162
Function: Chemotactic for neutrophil granulocytes

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008009chemokine activity IEA--
GO:0008201heparin binding IEA--
Find genes that share ontologies with CXCL6           About GenesLikeMe

     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cxcl5):
 hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

Find genes that share phenotypes with CXCL6           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Cxcl5tm1Gscw for CXCL6

   genOway: Develop your customized and physiologically relevant rodent model for CXCL6

miRTarBase miRNAs that target CXCL6:
hsa-mir-26b-5p (MIRT029714)

Block miRNA regulation of human, mouse, rat CXCL6 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CXCL6 (see all 9):
hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*
SwitchGear 3'UTR luciferase reporter plasmidCXCL6 3' UTR sequence
Inhib. RNA
OriGene RNAi products in human, mouse, rat for CXCL6
Predesigned siRNA for gene silencing in human, mouse, rat CXCL6

Gene Editing
DNA2.0 Custom Protein Engineering Service for CXCL6

OriGene clones in human, mouse for CXCL6 (see all 6)
OriGene ORF clones in mouse, rat for CXCL6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
Sino Biological Human cDNA Clone for CXCL6
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6

Cell Line
GenScript Custom overexpressing Cell Line Services for CXCL6
Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL6 
In Situ Assay

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot
CXCL6_HUMAN, P80162: Secreted
Subcellular locations from COMPARTMENTS: 


Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

Find genes that share ontologies with CXCL6           About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for CXCL6 About   (see all 12)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
IL-6 Pathway0.61
MIF Mediated Glucocorticoid Regulation0.94
STAT3 Pathway0.47
PEDF Induced Signaling0.73
Endothelin-1 Signaling Pathway0.46
all-trans-Retinoic Acid Signaling in Brain0.71
Cytokine-cytokine receptor interaction0.43
2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine receptors bind chemokines0.81
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
3Chemokine Signaling
Chemokine Signaling0.33
Chemokine signaling pathway0.33
4Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.44
5Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90

Find genes that share SuperPaths with CXCL6           About GenesLikeMe

Pathways by source                                   See SuperPaths
Show all pathways

1 R&D Systems Pathway for CXCL6
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL6 (see all 17)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Transendothelial Migration of Leukocytes
MIF Mediated Glucocorticoid Regulation

2 GeneGo (Thomson Reuters) Pathways for CXCL6
    Cytokine production by Th17 cells in CF (Mouse model)
Cytokine production by Th17 cells in CF

2 Reactome Pathways for CXCL6
    Chemokine receptors bind chemokines
G alpha (i) signalling events

4 Kegg Pathways  (Kegg details for CXCL6):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Rheumatoid arthritis

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL6 (see all 9): 
          Angiogenic Growth Factors in human mouse rat
          Wound Healing in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Angiogenesis in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat


    GeneGlobe Interaction Network for CXCL6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CXCL6 (P801623 ENSP000002263174) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
InteractantInteraction Details
GeneCardExternal ID(s)
CXCR2P250253, ENSP000003196354I2D: score=2 STRING: ENSP00000319635
MMP9P147803, ENSP000003614054I2D: score=2 STRING: ENSP00000361405
CXCR1P250243, ENSP000002956834I2D: score=2 STRING: ENSP00000295683
MMP1P039563I2D: score=1 
MMP12P399003I2D: score=1 
About this table

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis TAS9164944
GO:0006954inflammatory response TAS8399143
GO:0006955immune response IEA--
GO:0007165signal transduction TAS9164944
GO:0007267cell-cell signaling TAS9164944

Find genes that share ontologies with CXCL6           About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CXCL6

8 Novoseek inferred chemical compound relationships for CXCL6 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
grogamma 88.9 4 15832427 (2), 9054580 (1), 19594487 (1)
grobeta 87.8 9 15292528 (3), 15832427 (2), 19594487 (1)
groalpha 85.5 10 10540194 (2), 18174342 (2), 9054580 (1), 9365109 (1) (see all 6)
rantes 55.2 8 9516414 (3), 14707104 (2), 8805659 (1), 18290317 (1) (see all 5)
calcium 12.6 10 9057843 (1), 10570306 (1), 15476666 (1), 17699811 (1) (see all 8)
vegf 4.51 5 16332507 (3), 16377203 (1), 18290317 (1)
oxygen 0 1 16721367 (1)
serine 0 1 9516414 (1)

Find genes that share compounds with CXCL6           About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for CXCL6 gene: 

Unigene Cluster for CXCL6:

Chemokine (C-X-C motif) ligand 6
Hs.164021  [show with all ESTs]
Unigene Representative Sequence: NM_002993
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000226317(uc003hhf.3) ENST00000515050 ENST00000503446
Block miRNA regulation of human, mouse, rat CXCL6 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CXCL6 (see all 9):
hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*
SwitchGear 3'UTR luciferase reporter plasmidCXCL6 3' UTR sequence
Inhib. RNA
OriGene RNAi products in human, mouse, rat for CXCL6
Predesigned siRNA for gene silencing in human, mouse, rat CXCL6
OriGene clones in human, mouse for CXCL6 (see all 6)
OriGene ORF clones in mouse, rat for CXCL6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6
OriGene qPCR primer pairs and template standards for CXCL6
OriGene qSTAR qPCR primer pairs in human, mouse for CXCL6
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL6
  QuantiTect SYBR Green Assays in human, mouse, rat CXCL6
  QuantiFast Probe-based Assays in human, mouse, rat CXCL6

Additional mRNA sequence: 

AK311981.1 BC013744.1 U81234.1 Y08770.1 

2 DOTS entries:

DT.70104493  DT.121258772 

Selected AceView cDNA sequences (see all 59):

AU102795 CR614096 CB112103 BP338870 BM994397 AU098540 BQ717848 BP336724 
CR623302 AW515797 AU076718 BX380732 CA420646 CB853166 BQ694209 BU942618 
BP337169 BC013744 BG253033 BP336399 BG122200 BP335241 BX395981 AI668847 

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CXCL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CXCL6 Expression
About this image

CXCL6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
         PureStem 4D20.8, NCr-fac Progenitor
 Liver (Hepatobiliary System)
         Liver Lobule
 Mesoderm (Gastrulation Derivatives)
         PureStem 7SMOO32, NCr-fac & Meso Progenitor
 Heart (Cardiovascular System)
         Mature Cardiac Fibroblasts Myocardium
 Paraxial Mesoderm (Gastrulation Derivatives)
         PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
CXCL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CXCL6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.164021
    Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL6 (see all 9): 
          Angiogenic Growth Factors in human mouse rat
          Wound Healing in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Angiogenesis in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

OriGene qPCR primer pairs and template standards for CXCL6
OriGene qSTAR qPCR primer pairs in human, mouse for CXCL6
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL6
QuantiTect SYBR Green Assays in human, mouse, rat CXCL6
QuantiFast Probe-based Assays in human, mouse, rat CXCL6
In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CXCL6 gene from Selected species (see all 9)    About this table
Organism Taxonomic
Gene Description Human
(Mus musculus)
Mammalia Cxcl51 , 5 chemokine (C-X-C motif) ligand 51, 5 71.43(n)1
  5 (44.78 cM)5
203111  NM_009141.31  NP_033167.21 
(Gallus gallus)
Aves --
Uncharacterized protein
1 → many
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
1 → many

ENSEMBL Gene Tree for CXCL6 (if available)
TreeFam Gene Tree for CXCL6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for CXCL6 gene
PPBP2  PF42  CXCL12  PF4V12  CXCL32  CXCL52  CXCL22  IL82  
12 SIMAP similar genes for CXCL6 using alignment to 2 protein entries:     CXCL6_HUMAN (see all proteins):
CXCL5    IL8    CXCL3    CXCL1    CXCL2    PF4
CXCL10    CXCL12    CXCL9    PF4V1    PPBP    CXCL13

Find genes that share paralogs with CXCL6           About GenesLikeMe

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for CXCL6 (see all 125)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
Chr 4 posSequence#AA
C,A--74700367(+) aacatA/Tcgtgt 1 -- us2k11Minor allele frequency- T:0.00NA 2
C--74700432(+) TGGGAC/TGGCTG 1 -- us2k10--------
--74700445(+) TCAAAC/TGGTAT 1 -- us2k10--------
--74700465(+) TAGATA/CCCTGA 1 -- us2k10--------
C--74700530(+) AGTGTC/AAAAGT 1 -- us2k11Minor allele frequency- A:0.00NA 2
C--74700541(+) GTTCCT/CATTTC 1 -- us2k11Minor allele frequency- C:0.00NA 2
--74700733(+) CATCCA/GCTTTT 1 -- us2k10--------
--74700736(+) CCACTA/TTTTGA 1 -- us2k10--------
C--74700761(+) TTTTTC/GTTGTA 1 -- us2k10--------
C,A,H--74700826(+) ggtcgT/Cgaaaa 1 -- us2k1 tfbs31Minor allele frequency- C:0.00NA 2

HapMap Linkage Disequilibrium report for CXCL6 (74702214 - 74714781 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CXCL6:    About this table    
Variant IDTypeSubtypePubMed ID
nsv4389CNV Insertion18451855

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CXCL6
DNA2.0 Custom Variant and Variant Library Synthesis for CXCL6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 138965    OMIM disorders: --

2 diseases for CXCL6:    
About MalaCards
wegener's granulomatosis    periodontal disease

Find genes that share disorders with CXCL6           About GenesLikeMe

Selected Novoseek inferred disease relationships for CXCL6 gene (see all 16)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 43.8 9 18842116 (2), 18782286 (1), 16305697 (1), 18443119 (1) (see all 6)
osteosarcoma 40.6 8 9057843 (2), 9054580 (1), 9164944 (1), 9365109 (1) (see all 5)
tonsillitis 38.8 4 15807854 (3)
necrosis 19.3 2 12882792 (1), 12524079 (1)
sinusitis 18.8 1 12744776 (1)
pathological processes 12.7 3 12524079 (1), 12533683 (1)
tumors 12.6 21 11583968 (4), 15652347 (2), 18578857 (2), 9057843 (1) (see all 10)
neovascularization 9.79 1 15652347 (1)
osteoarthritis 6.82 7 15292528 (3), 14707104 (1)
asthma 0 1 16332507 (1)

Genetic Association Database (GAD): CXCL6
Human Genome Epidemiology (HuGE) Navigator: CXCL6 (7 documents)

Export disorders for CXCL6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CXCL6 gene, integrated from 10 sources (see all 116) (see top 10):
(articles sorted by number of sources associating them with CXCL6)

  1. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell- derived neutrophil activating peptide-78 mRNAs. (PubMed id 9057843)1, 2, 9 Froyen G.... Billiau A. (Eur. J. Biochem. 1997)
  2. Cloning and characterization of the human granulocyte chemotactic protein-2 gene. (PubMed id 9164944)1, 2, 9 Rovai L.E.... Smith J.B. (J. Immunol. 1997)
  3. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)1, 2, 9 Proost P....van Damme J. (J. Immunol. 1993)
  4. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. (PubMed id 8399143)1, 2, 9 Proost P.... van Damme J. (Biochemistry 1993)
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
  7. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
  8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  9. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)1, 4 Hillian A.D....Drumm M.L. (Genes Immun. 2008)
  10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
  11. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  12. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  13. Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids. (PubMed id 9465307)1, 3 Modi W.S. and Chen Z.Q. (Genomics 1998)
  14. The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma: comparison with interleukin-8/CXCL8. (PubMed id 12533683)1, 9 Wuyts A....Van Damme J. ( a journal of technical methods and pathology 2003)
  15. Granulocyte chemotactic protein 2 (gcp-2/cxcl6) complements interleukin-8 in periodontal disease. (PubMed id 18842116)1, 9 Kebschull M....Papapanou P.N. (J. Periodont. Res. 2009)
  16. Secretion of granulocyte chemotactic protein-2 by cultured human endometrial stromal cells. (PubMed id 12524079)1, 9 Mine S....Miyakawa I. (Fertil. Steril. 2003)
  17. CXCL6 (granulocyte chemotactic protein-2): a novel chemokine involved in the innate immune response of the amniotic cavity. (PubMed id 18782286)1, 9 Mittal P....Hassan S.S. (Am. J. Reprod. Immunol. 2008)
  18. Differential regulation of ENA-78 and GCP-2 gene expression in human corneal keratocytes and epithelial cells. (PubMed id 12882792)1, 9 Fillmore R.A....Oakes J.E. (amp 2003)
  19. Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78. (PubMed id 9692902)1, 9 Wuyts A....Wang J.M. (Eur. J. Biochem. 1998)
  20. Chemokine regulation of neutrophil function in surgical inflammation. (PubMed id 10593335)1, 9 Williams M.A....Solomkin J.S. (Arch Surg 1999)
  21. GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors. (PubMed id 15652347)1, 9 Gijsbers K....Van Damme J. (Exp. Cell Res. 2005)
  22. Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities. (PubMed id 12950257)1, 9 Van Den Steen P.E....Opdenakker G. (Eur. J. Biochem. 2003)
  23. CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue. (PubMed id 15214047)1, 9 Gijsbers K....Van Damme J. (Eur. J. Immunol. 2004)
  24. Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells. (PubMed id 12591113)1, 9 Prause O....LindAcn A. (Eur. J. Pharmacol. 2003)
  25. Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells. (PubMed id 17827342)1, 9 Vandercappellen J....Struyf S. (J. Leukoc. Biol. 2007)
  26. Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2. (PubMed id 12628493)1, 9 Catusse J....Paquet J.L. (Biochem. Pharmacol. 2003)
  27. Physical mapping of the CXC chemokine locus on human chromosome 4. (PubMed id 10343098)1, 9 O'Donovan N....Morgan J.G. (Cytogenet. Cell Genet. 1999)
  28. Gonadotropin-releasing hormone-regulated chemokine expression in human placentation. (PubMed id 19369450)1, 9 Cavanagh P.C....Babwah A.V. (Am. J. Physiol., Cell Physiol. 2009)
  29. The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial. (PubMed id 18443119)1, 9 Linge H.M....Egesten A. (Antimicrob. Agents Chemother. 2008)
  30. L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. (PubMed id 17022986)1, 9 Abe Y....Ballantyne C.M. (Atherosclerosis 2007)
  31. The chemokine CXCL6 restricts human trophoblast cell migration and invasion by suppressing MMP-2 activity in the first trimester. (PubMed id 23814098)1 Zhang H....Zhang W.Y. (Hum. Reprod. 2013)
  32. Mesenchymal stem cells overexpressing GCP-2 improve heart function through enhanced angiogenic properties in a myocardial infarction model. (PubMed id 22886775)1 Kim S.W....Kim M.H. (Cardiovasc. Res. 2012)
  33. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
  34. Isotypic neutralizing antibodies against mouse GCP-2/CXCL6 inhibit melanoma growth and metastasis. (PubMed id 21236563)1 Verbeke H....Van Damme J. (Cancer Lett. 2011)
  35. Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells. (PubMed id 20507572)1 Khalaf H....Olsson P.E. (BMC Immunol. 2010)
  36. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
  37. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (Sci Signal 2008)
  38. Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population. (PubMed id 15060097)4 Relton C.L....Burn J. (J. Med. Genet. 2004)
  39. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  40. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
  41. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  42. Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties. (PubMed id 9054580)9 Wuyts A....Van Damme J. (Biochemistry 1997)
  43. Granulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usage. (PubMed id 9365109)9 Van Damme J....Opdenakker G. (J. Leukoc. Biol. 1997)
  44. Granulocyte chemotactic protein-2 mediates adaptive immunity in part through IL-8Rbeta interactions. (PubMed id 15356099)9 Singh U.P....Lillard J.W. (J. Leukoc. Biol. 2004)
  45. Production and upregulation of granulocyte chemotactic protein-2/CXCL6 by IL-1beta and hypoxia in small cell lung cancer. (PubMed id 16721367)9 Zhu Y.M....Woll P.J. (Br. J. Cancer 2006)
  46. Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2. (PubMed id 8759763)9 Wuyts A....Van Damme J. (J. Immunol. 1996)
  47. Primary role of growth-related oncogene-alpha and granulocyte chemotactic protein-2 as neutrophil chemoattractants in chronic rhinosinusitis. (PubMed id 16776676)9 Rudack C....Alberty J. (Clin. Exp. Allergy 2006)
  48. Increased granulocyte chemotactic protein-2 concentrations in peritoneal fluid of women with endometriosis. (PubMed id 16305697)9 Suzumori N....Suzumori K. (Acta Obstet Gynecol Scand 2005)
  49. NH2- and COOH-terminal truncations of murine granulocyte chemotactic protein-2 augment the in vitro and in vivo neutrophil chemotactic potency. (PubMed id 10570306)9 Wuyts A....Van Damme J. (J. Immunol. 1999)
  50. Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2. (PubMed id 9485196)9 Wolf M....Baggiolini M. (Eur. J. Immunol. 1998)
  51. Lipid peroxides, superoxide dismutase and circulating IL-8 and GCP-2 in patients with severe obstructive sleep apnea: a pilot study. (PubMed id 15988615)9 Alzoghaibi M.A. and Bahammam A.S. (amp 2005)
  52. Detection of differentially expressed genes in synovial fibroblasts by restriction fragment differential display. (PubMed id 15292528)9 Scaife S....Buckley C.D. (Rheumatology (Oxford) 2004)
  53. Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5. (PubMed id 12439624)9 Smith J.B....Lusis A.J. (Immunogenetics 2002)
  54. Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle. (PubMed id 11583968)9 Van Coillie E....Opdenakker G. (Am. J. Pathol. 2001)
  55. GCP-2-induced internalization of IL-8 receptors: hierarchical relationships between GCP-2 and other ELR(+)-CXC chemokines and mechanisms regulating CXCR2 internalization and recycling. (PubMed id 10688807)9 Feniger-Barish R....Ben-Baruch A. (Blood 2000)
  56. Neutrophil chemokines GCP-2 and GRO-alpha in patients with inflammatory bowel disease. (PubMed id 18956592)9 Alzoghaibi M.A....Al-Jebreen A.M. (J Dig Dis 2008)
  57. Circulatory neutrophil chemokines in statin-treated diabetic patients. (PubMed id 18382804)9 Alfadda A.A. and Alzoghaibi M.A. (Saudi Med J 2008)
  58. Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages. (PubMed id 16332507)9 Verhoeckx K.C....Rodenburg R.J. (Int. Immunopharmacol. 2006)
  59. Neutrophil chemokines in epithelial inflammatory processes of human tonsils. (PubMed id 15807854)9 Sachse F....Rudack C. (Clin. Exp. Immunol. 2005)
  60. Biologically active neutrophil chemokine pattern in tonsillitis. (PubMed id 15008987)9 Rudack C....Sachse F. (Clin. Exp. Immunol. 2004)
  61. Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection. (PubMed id 9516414)9 Proost P.... Van Damme J. (J. Biol. Chem. 1998)
  62. Alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres. (PubMed id 18436867)9 Edman L.C....Arenas E. (Stem Cells 2008)
  63. The inflammatory microenvironment of the aging prostate facilitates cellular proliferation and hypertrophy. (PubMed id 18572414)9 Begley L.A....Macoska J.A. (Cytokine 2008)
  64. A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response. (PubMed id 18174342)9 Sumby P....Musser J.M. (Infect. Immun. 2008)
  65. Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA: Fallopian tube-specific mucosal immunity against viral infection. (PubMed id 17043099)9 Nasu K....Narahara H. (Hum. Reprod. 2007)
  66. Induction of CXC chemokines in A549 airway epithelial cells by trypsin and staphylococcal proteases - a possible route for neutrophilic inflammation in chronic rhinosinusitis. (PubMed id 16734624)9 Sachse F....Rudack C. (Clin. Exp. Immunol. 2006)
  67. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. (PubMed id 15100312)9 McLoughlin R.M....Jones S.A. (J. Immunol. 2004)
  68. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. (PubMed id 14707104)9 Pierer M....Kyburz D. (J. Immunol. 2004)
  69. The primary role in biologic activity of the neutrophil chemokines IL-8 and GRO-alpha in cultured nasal epithelial cells. (PubMed id 12744776)9 Rudack C....Schroeder J.M. (amp 2003)
  70. Sequence similarities of a subgroup of CXC chemokines related to murine LIX: implications for the interpretation of evolutionary relationships among chemokines. (PubMed id 9365114)9 Smith J.B....Herschman H.R. (J. Leukoc. Biol. 1997)
  71. Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes. (PubMed id 19628296)9 Qiu Z....Opdenakker G. (Immunobiology 2009)
  72. ELR+ CXC chemokine expression in benign and malignant colorectal conditions. (PubMed id 18578857)9 Rubie C....Schilling M.K. (BMC Cancer 2008)
  73. Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta. (PubMed id 18565769)9 Sandell L.J....Patra D. (Osteoarthr. Cartil. 2008)
  74. Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. (PubMed id 17197447)9 Fan X....Hipkin R.W. (J. Biol. Chem. 2007)
  75. CXC chemokines located in the 4q21 region are up-regulated in breast cancer. (PubMed id 18045955)9 BiA"che I....Lazennec G. (Endocr. Relat. Cancer 2007)
  76. Profiling of differentially expressed chemotactic-related genes in MCP-1 treated macrophage cell line using human cDNA arrays. (PubMed id 15832427)9 Bian G.X....Guo B.Y. (World J. Gastroenterol. 2005)
  77. IL-8-induced migratory responses through CXCR1 and CXCR2: association with phosphorylation and cellular redistribution of focal adhesion kinase. (PubMed id 12627953)9 Feniger-Barish R....Ben-Baruch A. (Biochemistry 2003)
  78. Neutrophil chemokines in cultured nasal fibroblasts. (PubMed id 12464044)9 Rudack C....Schroeder J.M. (Allergy 2002)
  79. Biochemical and biological characterization of neutrophil chemotactic protein, a novel rabbit CXC chemokine from alveolar macrophages. (PubMed id 11087410)9 Wuyts A....Van Damme J. (Biochemistry 2000)
  80. Release of CXC-chemokines by human lung microvascular endothelial cells (LMVEC) compared with macrovascular umbilical vein endothelial cells. (PubMed id 10540194)9 Beck G.C....Van Der Woude F.J. (Clin. Exp. Immunol. 1999)
  81. Purification and identification of human and mouse granulocyte chemotactic protein-2 isoforms. (PubMed id 9330312)9 Wuyts A....Van Damme J. (Meth. Enzymol. 1997)
  82. Differentially expressed genes associated with Staphylococcus aureus mastitis in dairy goats. (PubMed id 20060596)9 Pisoni G....Castiglioni B. (Vet. Immunol. Immunopathol. 2010)
  83. Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7. (PubMed id 18707017)9 Kalwitz G....Kaps C. (amp 2009)
  84. CXC and CC chemokines induced in human renal epithelial cells by inflammatory cytokines. (PubMed id 19594487)9 Thorburn E....Striz I. (APMIS 2009)
  85. Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches. (PubMed id 19082487)9 Lee S....Yoon D.Y. (Int. J. Oncol. 2009)
  86. Migration potential and gene expression profile of human mesenchymal stem cells induced by CCL25. (PubMed id 19168060)9 Binger T....Ringe J. (Exp. Cell Res. 2009)
  87. Leukocyte adhesion molecule and chemokine production through lipoteichoic acid recognition by toll-like receptor 2 in cultured human lymphatic endothelium. (PubMed id 18523807)9 Sawa Y....Yoshida S. (Cell Tissue Res. 2008)
  88. Th17 cells in airway diseases. (PubMed id 18691069)9 Traves S.L. and Donnelly L.E. (Curr. Mol. Med. 2008)
  89. Influences of aflatoxin B1 on reactive oxygen species generation and chemotaxis of human polymorphonuclear leukocytes. (PubMed id 18316174)9 Ubagai T....Ono Y. (Toxicol In Vitro 2008)
  90. Soot nanoparticles promote biotransformation, oxidative stress, and inflammation in murine lungs. (PubMed id 18367723)9 Rouse R.L....Penn A.L. (Am. J. Respir. Cell Mol. Biol. 2008)
  91. Activated protein C modulates chemokine response and tissue injury in experimental sepsis. (PubMed id 18290317)9 Sharma G.R....Grinnell B.W. (Adv. Exp. Med. Biol. 2008)
  92. Anti endothelial cell autoantibodies selectively activate SAPK/JNK signalling in Wegener's granulomatosis. (PubMed id 17699811)9 HolmAcn C....Sumitran-Holgersson S. (J. Am. Soc. Nephrol. 2007)
  93. Human oviductal stromal fibroblasts, but not oviductal epithelial cells, express Toll-like receptor 4: the site-specific mucosal immunity of the human fallopian tube against bacterial infection. (PubMed id 16836611)9 Itoh H....Narahara H. (Am. J. Reprod. Immunol. 2006)
  94. Heterogeneity in lipopolysaccharide responsiveness of endothelial cells identified by gene expression profiling: role of transcription factors. (PubMed id 16487252)9 Beck G.C....Yard B.A. (Clin. Exp. Immunol. 2006)
  95. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. (PubMed id 16237115)9 Numasaki M....Sasaki H. (J. Immunol. 2005)
  96. Chemokines synergize in the recruitment of circulating neutrophils into inflamed tissue. (PubMed id 15827963)9 Struyf S....Van Damme J. (Eur. J. Immunol. 2005)
  97. Cytokine interactions in mesenchymal stem cells from cord blood. (PubMed id 16377203)9 Liu C.H. and Hwang S.M. (Cytokine 2005)
  98. The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines. (PubMed id 15349826)9 Opdenakker G. and Van Damme J. (Int. J. Dev. Biol. 2004)
  99. Chemokines and gelatinases in the aqueous humor of patients with active uveitis. (PubMed id 15364222)9 Abu El-Asrar A.M....Geboes K. (Am. J. Ophthalmol. 2004)
  100. Rabbit neutrophil chemotactic protein (NCP) activates both CXCR1 and CXCR2 and is the functional homologue for human CXCL6. (PubMed id 15476666)9 Catusse J....Van Damme J. (Biochem. Pharmacol. 2004)
  101. The inflammatory side of human chondrocytes unveiled by antibody microarrays. (PubMed id 15381094)9 De Ceuninck F....Anract P. (Biochem. Biophys. Res. Commun. 2004)
  102. Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. (PubMed id 14662891)9 Gomez-Cambronero J....Baumann M.A. (J. Immunol. 2003)
  103. Neutrophils mediate parenchymal tissue necrosis and accelerate the rejection of complete major histocompatibility complex-disparate cardiac allografts in the absence of interferon-gamma. (PubMed id 12547709)9 Miura M....Fairchild R.L. (Am. J. Pathol. 2003)
  104. Modulation of gene expression induced in human epidermis by environmental stress in vivo. (PubMed id 14675196)9 Marionnet C....Dubertret L. (J. Invest. Dermatol. 2003)
  105. Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations. (PubMed id 11298490)9 Patel L....Macphee C.H. (Cytokine 2001)
  106. Actin filaments are involved in the regulation of trafficking of two closely related chemokine receptors, CXCR1 and CXCR2. (PubMed id 11145710)9 Zaslaver A....Ben-Baruch A. (J. Immunol. 2001)
  107. Identification of a blood-derived chemoattractant for neutrophils and lymphocytes as a novel CC chemokine, Regakine-1. (PubMed id 11290579)9 Struyf S....Van Damme J. (Blood 2001)
  108. Development of a homogeneous MAP kinase reporter gene screen for the identification of agonists and antagonists at the CXCR1 chemokine receptor. (PubMed id 11679162)9 Rees S....Beresford I.J. (J Biomol Screen 2001)
  109. The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. (PubMed id 11046061)9 Addison C.L....Strieter R.M. (J. Immunol. 2000)
  110. Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor. (PubMed id 10692502)9 Rosenkilde M.M. and Schwartz T.W. (Mol. Pharmacol. 2000)
  111. Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors. (PubMed id 10372118)9 Broxmeyer H.E....Pelus L.M. (Ann. N. Y. Acad. Sci. 1999)
  112. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)9 Wuyts A.... Van Damme J. (Eur. J. Biochem. 1999)
  113. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PubMed id 9064356)9 Loetscher M.... Moser B. (J. Exp. Med. 1996)

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Entrez Gene: 6372 HGNC: 10643 AceView: CXCL6 Ensembl:ENSG00000124875 euGenes: HUgn6372
ECgene: CXCL6 Kegg: 6372 H-InvDB: CXCL6

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PharmGKB entry for CXCL6 Pharmacogenomics, SNPs, Pathways

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 Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL6
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 Selected GeneTex proteins for CXCL6: GCP-2 Recombinant Protein (Active) (GTX48141-PRO)
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