CXCL6 Gene

Aliases
for CXCL6 gene

Previous GC identifers: GC04P074942 GC04P075102 GC04P075168 GC04P075067 GC04P074921 GC04P070513

Summaries
for CXCL6 gene

Genomic Views
for CXCL6 gene

RefSeq DNA sequence:

NC_000004.11  NC_018915.1  NT_022778.16  

SwitchGear Promoter luciferase reporter plasmid: CXCL6 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL6

CXCL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074691:  view genomic region     (about GC identifiers)

Proteins
for CXCL6 gene

Explore the universe of human proteins at neXtProt for CXCL6: NX_P80162

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CXCL6 (CXCL6/GCP-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CXCL6 OriGene Custom Protein Services for CXCL6
	GenScript Custom Purified and Recombinant Proteins Services for CXCL6
	Novus Biologicals CXCL6 Proteins Novus Biologicals CXCL6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CXCL6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CXCL6 (CXCL6/GCP-2)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CXCL6
	GenScript Custom Superior Antibodies Services for CXCL6
	Novus Biologicals CXCL6 Antibodies
	Abcam antibodies for CXCL6
	Uscn Antibodies for CXCL6
	Search ThermoFisher Antibodies for CXCL6

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CXCL6 (CXCL6/GCP-2)
	GenScript Custom Assay Services for CXCL6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CXCL6

Protein Domains /
Families
for CXCL6 gene

ProtoNet protein and cluster: P80162

Function
for CXCL6 gene

miRNA Products:		OriGene 3'-UTR Clone: CXCL6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL6
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL6 (see all 9):
		hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL6 (see all 7) OriGene shRNA RFP: CXCL6 OriGene siRNA: CXCL6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL6

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CXCL6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL6 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
		Sino Biological Human cDNA Clone for CXCL6
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL6
		Search LifeMap BioReagents cell lines for CXCL6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Cxcl5)

Pathways & Interactions
for CXCL6 gene

	Super-pathway	contained gene-specific pathways
1	PEDF Induced Signaling	8/9 pathways (see all 9) PEDF Induced Signaling 1.00 RAR-Gamma-RXR-Alpha Degradation 0.54 MIF Mediated Glucocorticoid Regulation 0.73 STAT3 Pathway 0.47 MIF Regulation of Innate Immune Cells 0.71 Endothelin-1 Signaling Pathway 0.44 IL-6 Pathway 0.61 Cytokine-cytokine receptor interaction 0.26
2	Class A/1 (Rhodopsin-like receptors)	Class A/1 (Rhodopsin-like receptors) 1.00 Peptide ligand-binding receptors 0.61 GPCR ligand binding 0.75 G alpha (i) signalling events 0.44
3	Rho Family GTPases	Rho Family GTPases 1.00 Molecular Mechanisms of Cancer 0.51 ERK Signaling 0.61
4	Signaling by GPCR	Signaling by GPCR 1.00 Signal Transduction 0.56 GPCR downstream signaling 0.89
5	PAK Pathway	PAK Pathway 1.00 Antioxidant Action of Vitamin-C 0.56

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL6

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

2 GeneGo (Thomson Reuters) Pathways for CXCL6

	Cytokine production by Th17 cells in CF (Mouse model)
	Cytokine production by Th17 cells in CF

5/8        Reactome Pathways for CXCL6

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

4         Kegg Pathways  (Kegg details for CXCL6)

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Pertussis
	Rheumatoid arthritis

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CXCL6 gene

Transcripts
for CXCL6 gene

Expression
for CXCL6 gene

CXCL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTTTTTG

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HeartMyocardiumMature Cardiac Fibroblasts			Epicardium
	AdiposeVisceral White Adipose			Adipose
	LiverLiver Lobule			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 8 LifeMap Cells
	Name			Category
	PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)			Cartilage, Neural Crest
	PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)			Lateral Plate Mesoderm, Neural Crest
	PureStem™ progenitor E44 (Embryonic Progenitor Cell)
	PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
	PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
	PureStem™ progenitor F15 (Embryonic Progenitor Cell)
	PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CXCL6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCL6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

Orthologs
for CXCL6 gene

Paralogs
for CXCL6 gene

Paralogs for CXCL6 gene

CXCL3²  CXCL5²  PPBP²  PF4²  CXCL1²  PF4V1²  IL8²  CXCL2²  

12 SIMAP similar genes for CXCL6 using alignment to 2 protein entries:     CXCL6_HUMAN (see all proteins):

CXCL5    IL8    CXCL3    CXCL1    CXCL2    PF4

CXCL10    CXCL12    CXCL9    PF4V1    PPBP    CXCL13

CXCL6 for paralogs           About GeneDecksing

Genomic Variants
for CXCL6 gene

Disorders / Diseases
for CXCL6 gene

20/32 diseases for CXCL6

10/16 Novoseek disease relationships for CXCL6 gene (see all 16)    About this table

Publications
for CXCL6 gene

PubMed articles for CXCL6 gene, integrated from 9 sources (see all 114) (see top 10): (articles sorted by number of sources associating them with CXCL6)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell- derived neutrophil activating peptide-78 mRNAs. (PubMed id 9057843)^{1, 2, 9} Froyen G.... Billiau A. (1997)
2. Cloning and characterization of the human granulocyte chemotactic protein-2 gene. (PubMed id 9164944)^{1, 2, 9} Rovai L.E.... Smith J.B. (1997)
3. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)^{1, 2, 9} Proost P....van Damme J. (1993)
4. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. (PubMed id 8399143)^{1, 2, 9} Proost P.... van Damme J. (1993)
5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids. (PubMed id 9465307)^{1, 3} Modi W.S. and Chen Z.Q. (1998)
8. The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma: comparison with interleukin-8/CXCL8. (PubMed id 12533683)^{1, 9} Wuyts A....Van Damme J. (2003)
9. Granulocyte chemotactic protein 2 (gcp-2/cxcl6) compl ements interleukin-8 in periodontal disease. (PubMed id 18842116)^{1, 9} Kebschull M....Papapanou P.N. (2009)
10. Secretion of granulocyte chemotactic protein-2 by cultured human endometrial stromal cells. (PubMed id 12524079)^{1, 9} Mine S....Miyakawa I. (2003)
11. CXCL6 (granulocyte chemotactic protein-2): a novel chemokine involved in the innate immune response of the amniotic cavity. (PubMed id 18782286)^{1, 9} Mittal P....Hassan S.S. (2008)
12. Differential regulation of ENA-78 and GCP-2 gene expression in human corneal keratocytes and epithelial cells. (PubMed id 12882792)^{1, 9} Fillmore R.A....Oakes J.E. (2003)
13. Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78. (PubMed id 9692902)^{1, 9} Wuyts A....Wang J.M. (1998)
14. Chemokine regulation of neutrophil function in surgical inflammation. (PubMed id 10593335)^{1, 9} Williams M.A....Solomkin J.S. (1999)
15. GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors. (PubMed id 15652347)^{1, 9} Gijsbers K....Van Damme J. (2005)
16. Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities. (PubMed id 12950257)^{1, 9} Van Den Steen P.E....Opdenakker G. (2003)
17. CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue. (PubMed id 15214047)^{1, 9} Gijsbers K....Van Damme J. (2004)
18. Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells. (PubMed id 12591113)^{1, 9} Prause O....Linden A. (2003)
19. Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells. (PubMed id 17827342)^{1, 9} Vandercappellen J....Struyf S. (2007)
20. Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2. (PubMed id 12628493)^{1, 9} Catusse J....Paquet J.L. (2003)
21. Physical mapping of the CXC chemokine locus on human chromosome 4. (PubMed id 10343098)^{1, 9} O'Donovan N....Morgan J.G. (1999)
22. Gonadotropin-releasing hormone-regulated chemokine ex pression in human placentation. (PubMed id 19369450)^{1, 9} Cavanagh P.C....Babwah A.V. (2009)
23. The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial. (PubMed id 18443119)^{1, 9} Linge H.M....Egesten A. (2008)
24. L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. (PubMed id 17022986)^{1, 9} Abe Y....Ballantyne C.M. (2007)
25. Mesenchymal stem cells overexpressing GCP-2 improve he art function through enhanced angiogenic properties in a myocardial infarction m odel. (PubMed id 22886775)¹ Kim S.W....Kim M.H. (2012)
26. Isotypic neutralizing antibodies against mouse GCP-2/ CXCL6 inhibit melanoma growth and metastasis. (PubMed id 21236563)¹ Verbeke H....Van Damme J. (2011)
27. Differential cytokine regulation by NF-kappaB and AP- 1 in Jurkat T-cells. (PubMed id 20507572)¹ Khalaf H....Olsson P.E. (2010)
28. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)¹ Schuurhof A....Janssen R. (2010)
29. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)¹ Johnatty S.E.... . (2010)
30. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)
31. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)¹ Siezen C.L....Janssen R. (2009)
32. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)¹ Luttrell L.M. (2008)
33. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)¹ Lambert N.A. (2008)
34. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)¹ Hillian A.D....Drumm M.L. (2008)
35. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)¹ Janssen R....Hoebee B. (2007)
36. Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population. (PubMed id 15060097)⁴ Relton C.L....Burn J. (2004)
37. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
38. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
39. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
40. Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties. (PubMed id 9054580)⁹ Wuyts A....Van Damme J. (1997)
41. Granulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usage. (PubMed id 9365109)⁹ Van Damme J....Opdenakker G. (1997)
42. Granulocyte chemotactic protein-2 mediates adaptive immunity in part through IL-8Rbeta interactions. (PubMed id 15356099)⁹ Singh U.P....Lillard J.W. (2004)
43. Production and upregulation of granulocyte chemotactic protein-2/CXCL6 by IL-1beta and hypoxia in small cell lung cancer. (PubMed id 16721367)⁹ Zhu Y.M....Woll P.J. (2006)
44. Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2. (PubMed id 8759763)⁹ Wuyts A....Van Damme J. (1996)
45. Primary role of growth-related oncogene-alpha and granulocyte chemotactic protein-2 as neutrophil chemoattractants in chronic rhinosinusitis. (PubMed id 16776676)⁹ Rudack C....Alberty J. (2006)
46. Increased granulocyte chemotactic protein-2 concentrations in peritoneal fluid of women with endometriosis. (PubMed id 16305697)⁹ Suzumori N....Suzumori K. (2005)
47. NH2- and COOH-terminal truncations of murine granulocyte chemotactic protein-2 augment the in vitro and in vivo neutrophil chemotactic potency. (PubMed id 10570306)⁹ Wuyts A....Van Damme J. (1999)
48. Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2. (PubMed id 9485196)⁹ Wolf M....Baggiolini M. (1998)
49. Lipid peroxides, superoxide dismutase and circulating IL-8 and GCP-2 in patients with severe obstructive sleep apnea: a pilot study. (PubMed id 15988615)⁹ Alzoghaibi M.A. and Bahammam A.S. (2005)
50. Detection of differentially expressed genes in synovial fibroblasts by restriction fragment differential display. (PubMed id 15292528)⁹ Scaife S....Buckley C.D. (2004)
51. Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5. (PubMed id 12439624)⁹ Smith J.B....Lusis A.J. (2002)
52. Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle. (PubMed id 11583968)⁹ Van Coillie E....Opdenakker G. (2001)
53. GCP-2-induced internalization of IL-8 receptors: hierarchical relationships between GCP-2 and other ELR(+)-CXC chemokines and mechanisms regulating CXCR2 internalization and recycling. (PubMed id 10688807)⁹ Feniger-Barish R....Ben-Baruch A. (2000)
54. Neutrophil chemokines GCP-2 and GRO-alpha in patients with inflammatory bowel disease. (PubMed id 18956592)⁹ Alzoghaibi M.A....Al-Jebreen A.M. (2008)
55. Circulatory neutrophil chemokines in statin-treated diabetic patients. (PubMed id 18382804)⁹ Alfadda A.A. and Alzoghaibi M.A. (2008)
56. Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages. (PubMed id 16332507)⁹ Verhoeckx K.C....Rodenburg R.J. (2006)
57. Neutrophil chemokines in epithelial inflammatory processes of human tonsils. (PubMed id 15807854)⁹ Sachse F....Rudack C. (2005)
58. Biologically active neutrophil chemokine pattern in tonsillitis. (PubMed id 15008987)⁹ Rudack C....Sachse F. (2004)
59. Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection. (PubMed id 9516414)⁹ Proost P.... Van Damme J. (1998)
60. Alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres. (PubMed id 18436867)⁹ Edman L.C....Arenas E. (2008)
61. The inflammatory microenvironment of the aging prostate facilitates cellular proliferation and hypertrophy. (PubMed id 18572414)⁹ Begley L.A....Macoska J.A. (2008)
62. A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response. (PubMed id 18174342)⁹ Sumby P....Musser J.M. (2008)
63. Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA: Fallopian tube-specific mucosal immunity against viral infection. (PubMed id 17043099)⁹ Nasu K....Narahara H. (2007)
64. Induction of CXC chemokines in A549 airway epithelial cells by trypsin and staphylococcal proteases - a possible route for neutrophilic inflammation in chronic rhinosinusitis. (PubMed id 16734624)⁹ Sachse F....Rudack C. (2006)
65. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. (PubMed id 15100312)⁹ McLoughlin R.M....Jones S.A. (2004)
66. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. (PubMed id 14707104)⁹ Pierer M....Kyburz D. (2004)
67. The primary role in biologic activity of the neutrophil chemokines IL-8 and GRO-alpha in cultured nasal epithelial cells. (PubMed id 12744776)⁹ Rudack C....Schroeder J.M. (2003)
68. Sequence similarities of a subgroup of CXC chemokines related to murine LIX: implications for the interpretation of evolutionary relationships among chemokines. (PubMed id 9365114)⁹ Smith J.B....Herschman H.R. (1997)
69. Interleukin-17 regulates chemokine and gelatinase B e xpression in fibroblasts to recruit both neutrophils and monocytes. (PubMed id 19628296)⁹ Qiu Z....Opdenakker G. (2009)
70. ELR+ CXC chemokine expression in benign and malignant colorectal conditions. (PubMed id 18578857)⁹ Rubie C....Schilling M.K. (2008)
71. Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta. (PubMed id 18565769)⁹ Sandell L.J....Patra D. (2008)
72. Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. (PubMed id 17197447)⁹ Fan X....Hipkin R.W. (2007)
73. CXC chemokines located in the 4q21 region are up-regulated in breast cancer. (PubMed id 18045955)⁹ Bieche I....Lazennec G. (2007)
74. Profiling of differentially expressed chemotactic-related genes in MCP-1 treated macrophage cell line using human cDNA arrays. (PubMed id 15832427)⁹ Bian G.X....Guo B.Y. (2005)
75. IL-8-induced migratory responses through CXCR1 and CXCR2: association with phosphorylation and cellular redistribution of focal adhesion kinase. (PubMed id 12627953)⁹ Feniger-Barish R....Ben-Baruch A. (2003)
76. Neutrophil chemokines in cultured nasal fibroblasts. (PubMed id 12464044)⁹ Rudack C....Schroeder J.M. (2002)
77. Biochemical and biological characterization of neutrophil chemotactic protein, a novel rabbit CXC chemokine from alveolar macrophages. (PubMed id 11087410)⁹ Wuyts A....Van Damme J. (2000)
78. Release of CXC-chemokines by human lung microvascular endothelial cells (LMVEC) compared with macrovascular umbilical vein endothelial cells. (PubMed id 10540194)⁹ Beck G.C....Van Der Woude F.J. (1999)
79. Purification and identification of human and mouse gr anulocyte chemotactic protein-2 isoforms. (PubMed id 9330312)⁹ Wuyts A....Van Damme J. (1997)
80. Differentially expressed genes associated with Staphy lococcus aureus mastitis in dairy goats. (PubMed id 20060596)⁹ Pisoni G....Castiglioni B. (2010)
81. Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7. (PubMed id 18707017)⁹ Kalwitz G....Kaps C. (2009)
82. CXC and CC chemokines induced in human renal epitheli al cells by inflammatory cytokines. (PubMed id 19594487)⁹ Thorburn E....Striz I. (2009)
83. Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches. (PubMed id 19082487)⁹ Lee S....Yoon D.Y. (2009)
84. Migration potential and gene expression profile of human mesenchymal stem cells induced by CCL25. (PubMed id 19168060)⁹ Binger T....Ringe J. (2009)
85. Leukocyte adhesion molecule and chemokine production through lipoteichoic acid recognition by toll-like receptor 2 in cultured human lymphatic endothelium. (PubMed id 18523807)⁹ Sawa Y....Yoshida S. (2008)
86. Th17 cells in airway diseases. (PubMed id 18691069)⁹ Traves S.L. and Donnelly L.E. (2008)
87. Influences of aflatoxin B1 on reactive oxygen species generation and chemotaxis of human polymorphonuclear leukocytes. (PubMed id 18316174)⁹ Ubagai T....Ono Y. (2008)
88. Soot nanoparticles promote biotransformation, oxidative stress, and inflammation in murine lungs. (PubMed id 18367723)⁹ Rouse R.L....Penn A.L. (2008)
89. Activated protein C modulates chemokine response and tissue injury in experimental sepsis. (PubMed id 18290317)⁹ Sharma G.R....Grinnell B.W. (2008)
90. Anti endothelial cell autoantibodies selectively activate SAPK/JNK signalling in Wegener's granulomatosis. (PubMed id 17699811)⁹ Holmen C....Sumitran-Holgersson S. (2007)
91. Human oviductal stromal fibroblasts, but not oviductal epithelial cells, express Toll-like receptor 4: the site-specific mucosal immunity of the human fallopian tube against bacterial infection. (PubMed id 16836611)⁹ Itoh H....Narahara H. (2006)
92. Heterogeneity in lipopolysaccharide responsiveness of endothelial cells identified by gene expression profiling: role of transcription factors. (PubMed id 16487252)⁹ Beck G.C....Yard B.A. (2006)
93. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. (PubMed id 16237115)⁹ Numasaki M....Sasaki H. (2005)
94. Chemokines synergize in the recruitment of circulating neutrophils into inflamed tissue. (PubMed id 15827963)⁹ Struyf S....Van Damme J. (2005)
95. Cytokine interactions in mesenchymal stem cells from cord blood. (PubMed id 16377203)⁹ Liu C.H. and Hwang S.M. (2005)
96. The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines. (PubMed id 15349826)⁹ Opdenakker G. and Van Damme J. (2004)
97. Chemokines and gelatinases in the aqueous humor of patients with active uveitis. (PubMed id 15364222)⁹ Abu El-Asrar A.M....Geboes K. (2004)
98. Rabbit neutrophil chemotactic protein (NCP) activates both CXCR1 and CXCR2 and is the functional homologue for human CXCL6. (PubMed id 15476666)⁹ Catusse J....Van Damme J. (2004)
99. The inflammatory side of human chondrocytes unveiled by antibody microarrays. (PubMed id 15381094)⁹ De Ceuninck F....Anract P. (2004)
100. Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. (PubMed id 14662891)⁹ Gomez-Cambronero J....Baumann M.A. (2003)
101. Neutrophils mediate parenchymal tissue necrosis and accelerate the rejection of complete major histocompatibility complex-disparate cardiac allografts in the absence of interferon-gamma. (PubMed id 12547709)⁹ Miura M....Fairchild R.L. (2003)
102. Modulation of gene expression induced in human epidermis by environmental stress in vivo. (PubMed id 14675196)⁹ Marionnet C....Dubertret L. (2003)
103. Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations. (PubMed id 11298490)⁹ Patel L....Macphee C.H. (2001)
104. Actin filaments are involved in the regulation of trafficking of two closely related chemokine receptors, CXCR1 and CXCR2. (PubMed id 11145710)⁹ Zaslaver A....Ben-Baruch A. (2001)
105. Identification of a blood-derived chemoattractant for neutrophils and lymphocytes as a novel CC chemokine, Regakine-1. (PubMed id 11290579)⁹ Struyf S....Van Damme J. (2001)
106. Development of a homogeneous MAP kinase reporter gene screen for the identification of agonists and antagonists at the CXCR1 chemokine receptor. (PubMed id 11679162)⁹ Rees S....Beresford I.J. (2001)
107. The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. (PubMed id 11046061)⁹ Addison C.L....Strieter R.M. (2000)
108. Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor. (PubMed id 10692502)⁹ Rosenkilde M.M. and Schwartz T.W. (2000)
109. Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors. (PubMed id 10372118)⁹ Broxmeyer H.E....Pelus L.M. (1999)
110. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)⁹ Wuyts A.... Van Damme J. (1999)
111. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PubMed id 9064356)⁹ Loetscher M.... Moser B. (1996)
112. I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis. (PubMed id 8805659)⁹ Van Snick J....Renauld J.C. (1996)
113. Purification, sequence analysis, and biological characterization of a second bovine monocyte chemotactic protein-1 (Bo MCP-1B). (PubMed id 7947749)⁹ Proost P....Van Damme J. (1994)

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