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Aliases for CXCL6 Gene

Aliases for CXCL6 Gene

  • Chemokine (C-X-C Motif) Ligand 6 2 3
  • Granulocyte Chemotactic Protein 2 2 3 4
  • SCYB6 3 4 6
  • GCP2 3 4 6
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 6 (Granulocyte Chemotactic Protein 2) 2 3
  • Chemokine (C-X-C Motif) Ligand 6 (Granulocyte Chemotactic Protein 2) 2 3
  • Small-Inducible Cytokine B6 3 4
  • Chemokine Alpha 3 3 4
  • CKA-3 3 4
  • GCP-2 3 4
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member B 3
  • C-X-C Motif Chemokine 6 3

External Ids for CXCL6 Gene

Previous Symbols for CXCL6 Gene

  • SCYB6

Summaries for CXCL6 Gene

GeneCards Summary for CXCL6 Gene

CXCL6 (Chemokine (C-X-C Motif) Ligand 6) is a Protein Coding gene. Diseases associated with CXCL6 include periodontal disease. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for CXCL6 Gene

  • Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL6 Gene

Genomics for CXCL6 Gene

Genomic Location for CXCL6 Gene

Start:
73,836,497 bp from pter
End:
73,849,064 bp from pter
Size:
12,568 bases
Orientation:
Plus strand

Genomic View for CXCL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL6 Gene

Regulatory Elements for CXCL6 Gene

Proteins for CXCL6 Gene

  • Protein details for CXCL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80162-CXCL6_HUMAN
    Recommended name:
    C-X-C motif chemokine 6
    Protein Accession:
    P80162
    Secondary Accessions:
    • B2R4X3
    • Q4W5D4

    Protein attributes for CXCL6 Gene

    Size:
    114 amino acids
    Molecular mass:
    11897 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL6 Gene

Proteomics data for CXCL6 Gene at MOPED

Post-translational modifications for CXCL6 Gene

No Post-translational modifications

Other Protein References for CXCL6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL6 Gene

Domains for CXCL6 Gene

Gene Families for CXCL6 Gene

HGNC:

Protein Domains for CXCL6 Gene

UniProtKB/Swiss-Prot:

CXCL6_HUMAN
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.:
    • P80162
genes like me logo Genes that share domains with CXCL6: view

Function for CXCL6 Gene

Molecular function for CXCL6 Gene

UniProtKB/Swiss-Prot Function: Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).

Gene Ontology (GO) - Molecular Function for CXCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IEA --
GO:0008201 heparin binding IEA --
GO:0045236 CXCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CXCL6: view
genes like me logo Genes that share phenotypes with CXCL6: view

Animal Models for CXCL6 Gene

MGI Knock Outs for CXCL6:

miRNA for CXCL6 Gene

miRTarBase miRNAs that target CXCL6

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CXCL6 Gene

Localization for CXCL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL6 Gene COMPARTMENTS Subcellular localization image for CXCL6 gene
Compartment Confidence
extracellular 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CXCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CXCL6: view

Pathways for CXCL6 Gene

genes like me logo Genes that share pathways with CXCL6: view

Gene Ontology (GO) - Biological Process for CXCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002446 neutrophil mediated immunity IBA --
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 9164944
GO:0006954 inflammatory response TAS 8399143
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with CXCL6: view

Compounds for CXCL6 Gene

(8) Novoseek inferred chemical compound relationships for CXCL6 Gene

Compound -log(P) Hits PubMed IDs
grogamma 88.9 4
grobeta 87.8 6
groalpha 85.5 8
rantes 55.2 8
calcium 12.6 8
genes like me logo Genes that share compounds with CXCL6: view

Transcripts for CXCL6 Gene

mRNA/cDNA for CXCL6 Gene

Unigene Clusters for CXCL6 Gene

Chemokine (C-X-C motif) ligand 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL6 Gene

No ASD Table

Relevant External Links for CXCL6 Gene

GeneLoc Exon Structure for
CXCL6
ECgene alternative splicing isoforms for
CXCL6

Expression for CXCL6 Gene

mRNA expression in normal human tissues for CXCL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL6 Gene

This gene is overexpressed in Spleen (21.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CXCL6 Gene

SOURCE GeneReport for Unigene cluster for CXCL6 Gene Hs.164021

genes like me logo Genes that share expressions with CXCL6: view

Orthologs for CXCL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL6 36
  • 98.83 (n)
  • 96.49 (a)
CXCL6 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL6 37
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cxcl5 36
  • 71.43 (n)
  • 64.94 (a)
Cxcl5 16
Cxcl5 37
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 43 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
-- 37
  • 37 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cxcl5 36
  • 69.3 (n)
  • 59.65 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 37 (a)
OneToMany
Species with no ortholog for CXCL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL6 Gene

ENSEMBL:
Gene Tree for CXCL6 (if available)
TreeFam:
Gene Tree for CXCL6 (if available)

Paralogs for CXCL6 Gene

Paralogs for CXCL6 Gene

Selected SIMAP similar genes for CXCL6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CXCL6: view

Variants for CXCL6 Gene

Sequence variations from dbSNP and Humsavar for CXCL6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1951243 -- 73,836,413(+) ACCCT(C/G)CTGAA upstream-variant-2KB
rs1957077 -- 73,838,574(+) ATATA(C/T)AGCAT utr-variant-3-prime
rs1957078 -- 73,838,865(+) TCATT(A/C)CCCAA downstream-variant-500B
rs1957079 -- 73,839,080(+) TCATC(A/G)GTACT downstream-variant-500B
rs4417936 -- 73,837,134(+) ACTTA(A/G)GCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL6 Gene

Variant ID Type Subtype PubMed ID
nsv4389 CNV Insertion 18451855

Relevant External Links for CXCL6 Gene

HapMap Linkage Disequilibrium report
CXCL6

Disorders for CXCL6 Gene

(1) MalaCards Diseases for CXCL6 Gene

Search for CXCL6 Gene in MalaCards »

(16) Novoseek inferred disease relationships for CXCL6 Gene

Disease -log(P) Hits PubMed IDs
inflammation 43.8 7
osteosarcoma 40.6 6
tonsillitis 38.8 3
necrosis 19.3 2
sinusitis 18.8 1

Relevant External Links for CXCL6

Genetic Association Database (GAD)
CXCL6
Human Genome Epidemiology (HuGE) Navigator
CXCL6
genes like me logo Genes that share disorders with CXCL6: view

No data available for UniProtKB/Swiss-Prot for CXCL6 Gene

Publications for CXCL6 Gene

  1. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. (PMID: 8399143) Proost P. … van Damme J. (Biochemistry 1993) 3 4 23
  2. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PMID: 8423327) Proost P. … van Damme J. (J. Immunol. 1993) 3 4 23
  3. Cloning and characterization of the human granulocyte chemotactic protein-2 gene. (PMID: 9164944) Rovai L.E. … Smith J.B. (J. Immunol. 1997) 3 4 23
  4. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell- derived neutrophil activating peptide-78 mRNAs. (PMID: 9057843) Froyen G. … Billiau A. (Eur. J. Biochem. 1997) 3 4 23
  5. The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial. (PMID: 18443119) Linge H.M. … Egesten A. (Antimicrob. Agents Chemother. 2008) 3 4 23

Products for CXCL6 Gene

Sources for CXCL6 Gene

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