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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL6 Gene

protein-coding   GIFtS: 57
GCID: GC04P074691

chemokine (C-X-C motif) ligand 6

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbol: SCYB6)
 Explore 32 diseases affiliated with
CXCL6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CXCL6    

Aliases
for CXCL6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-X-C Motif) Ligand 61 2     Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 6 (Granulocyte
Chemotactic Protein 2)1 2
SCYB61 2 3 5     Chemokine Alpha 32 3
CKA-31 2 3     Granulocyte Chemotactic Protein 22 3
GCP-21 2 3     Small-Inducible Cytokine B62 3
GCP22 3 5     C-X-C Motif Chemokine 62
Chemokine (C-X-C Motif) Ligand 6 (Granulocyte Chemotactic Protein 2)1 2     Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member B2

External Ids:    HGNC: 106431   Entrez Gene: 63722   Ensembl: ENSG000001248757   OMIM: 1389655   UniProtKB: P801623   

Export aliases for CXCL6 gene to outside databases

Previous GC identifers: GC04P074942 GC04P075102 GC04P075168 GC04P075067 GC04P074921 GC04P070513


Summaries
for CXCL6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162
Function: Chemotactic for neutrophil granulocytes




Genomic Views
for CXCL6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL6 gene promoter:
         SRF   RFX1   Pbx1a   MEF-2   SRF (504 AA)   Lmo2   AP-4   MEF-2A   aMEF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

CXCL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074691:  view genomic region     (about GC identifiers)

Start:
 74,702,214 bp from pter      End:
 74,714,781 bp from pter
Size:
 12,568 bases      Orientation:
 plus strand

Proteins
for CXCL6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162 (See protein sequence)
Recommended Name: C-X-C motif chemokine 6 precursor  
Size: 114 amino acids; 11897 Da
Subcellular location: Secreted
Secondary accessions: B2R4X3 Q4W5D4

Explore the universe of human proteins at neXtProt for CXCL6: NX_P80162

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P80162

    • CXCL6 Protein expression data from MOPED and PaxDb:    About this image 
    CXCL6 Protein Expression
    REFSEQ proteins: NP_002984.1  
    ENSEMBL proteins: 
     ENSP00000226317   ENSP00000424819  
    Reactome Protein details: P80162
    Human Recombinant Protein Products for CXCL6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL6 (CXCL6/GCP-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CXCL6
    OriGene Custom Protein Services for CXCL6 
    GenScript Custom Purified and Recombinant Proteins Services for CXCL6
    Novus Biologicals CXCL6 Proteins
    Novus Biologicals CXCL6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CXCL6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CXCL6 for ontologies           About GeneDecksing



    CXCL6 Antibody Products: 
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    Novus Biologicals CXCL6 Antibodies
    Abcam antibodies for CXCL6 
    Uscn Antibodies for CXCL6
    Search ThermoFisher Antibodies for CXCL6

    Assay Products for CXCL6: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CXCL6 (CXCL6/GCP-2)
    GenScript Custom Assay Services for CXCL6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CXCL6

    Protein Domains /
    Families
    for CXCL6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CXCL6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P80162

    ProtoNet protein and cluster: P80162

    1 Blocks protein family: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Function
    for CXCL6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCL6_HUMAN, P80162
    Function: Chemotactic for neutrophil granulocytes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--
    GO:0008201heparin binding IEA--
         
    CXCL6 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cxcl5):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    CXCL6 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Cxcl5tm1Gscw for CXCL6
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CXCL6 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CXCL6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL6
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL6 (see all 9):
    hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL6 (see all 7)
    OriGene shRNA RFP: CXCL6
    OriGene siRNA: CXCL6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL6
    Sirion Biotech Custom design and validation of potent shRNA sequences against CXCL6 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CXCL6
    Sirion Biotech Customized adenovirus for overexpression of CXCL6 
    Sirion Biotech Customized adenovirus for potent knockdown of CXCL6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CXCL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
    Sino Biological Human cDNA Clone for CXCL6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6 

    Cell Line
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    Search LifeMap BioReagents cell lines for CXCL6
    Sirion Biotech Customized stable knockdown cell line services for CXCL6 
    Sirion Biotech Customized inducible knockdown cell line services for CXCL6
    Sirion Biotech Customized stable overexpressing cell line services for CXCL6
    Sirion Biotech Customized inducible overexpressing cell line services for CXCL6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6


    Pathways & Interactions
    for CXCL6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/9 pathways (see all 9)
    		PEDF Induced Signaling1.00
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Mediated Glucocorticoid Regulation0.73
    		STAT3 Pathway0.47
    		MIF Regulation of Innate Immune Cells0.71
    		Endothelin-1 Signaling Pathway0.44
    		IL-6 Pathway0.61
    		Cytokine-cytokine receptor interaction0.26
    2Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    4Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    5PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL6 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    2 GeneGo (Thomson Reuters) Pathways for CXCL6
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF

    5/8        Reactome Pathways for CXCL6 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    4         Kegg Pathways  (Kegg details for CXCL6):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Pertussis
    Rheumatoid arthritis


    CXCL6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/154 Interacting proteins for CXCL6 (P801623 ENSP000002263174) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250253, ENSP000003196354I2D: score=2 STRING: ENSP00000319635
    MMP9P147803, ENSP000003614054I2D: score=2 STRING: ENSP00000361405
    CXCR1P250243, ENSP000002956834I2D: score=2 STRING: ENSP00000295683
    MMP1P039563I2D: score=1 
    MMP12P399003I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response TAS8399143
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS9164944
    GO:0007267cell-cell signaling TAS9164944

    CXCL6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CXCL6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL6
    8 Novoseek chemical compound relationships for CXCL6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grogamma 88.9 4 15832427 (2), 9054580 (1), 19594487 (1)
    grobeta 87.8 9 15292528 (3), 15832427 (2), 19594487 (1)
    groalpha 85.5 10 10540194 (2), 18174342 (2), 9054580 (1), 9365109 (1) (see all 6)
    rantes 55.2 8 9516414 (3), 14707104 (2), 8805659 (1), 18290317 (1) (see all 5)
    calcium 12.6 10 9057843 (1), 10570306 (1), 15476666 (1), 17699811 (1) (see all 8)
    vegf 4.51 5 16332507 (3), 16377203 (1), 18290317 (1)
    oxygen 0 1 16721367 (1)
    serine 0 1 9516414 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCL6 

    Transcripts
    for CXCL6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CXCL6 gene: 
    NM_002993.3  

    Unigene Cluster for CXCL6:

    Chemokine (C-X-C motif) ligand 6
    Hs.164021  [show with all ESTs]
    Unigene Representative Sequence: NM_002993
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226317(uc003hhf.3) ENST00000515050 ENST00000503446

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CXCL6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL6
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL6 (see all 9):
    hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CXCL6 (see all 7) (see first 1)
    NM_002993 (human cat#: TG319821)  BC024392 (mouse cat#: TG501993)  BC024392 (mouse cat#: TR501993)  
    BC024392 (mouse cat#: TF501993)  
    OriGene shRNA RFP: CXCL6
    OriGene siRNA: CXCL6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL6
    Sirion Biotech Custom design and validation of potent shRNA sequences against CXCL6 
    Clone
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    GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CXCL6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL6

    Additional cDNA sequence: 

    AK311981.1 BC013744.1 U81234.1 Y08770.1 

    2 DOTS entries:

    DT.70104493  DT.121258772 

    24/59 AceView cDNA sequences (see all 59):

    BP336724 CR614096 AW515797 AU098540 AU102795 BQ717848 CR623302 CB112103 
    BM994397 AU076718 BP338870 U81234 BP336399 BP337169 BM995310 CA420646 
    BP335241 NM_002993 CA416348 BG253033 BM981549 AI391519 BG122844 BP337673 

    GeneLoc Exon Structure


    Expression
    for CXCL6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGGTTTTTG
    CXCL6 Expression
    About this image

    CXCL6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartMyocardiumMature Cardiac FibroblastsEpicardium
    AdiposeVisceral White AdiposeAdipose
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

    See CXCL6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL6

    SOURCE GeneReport for Unigene cluster: Hs.164021
        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL6 (see all 9): 
              Angiogenic Growth Factors in human mouse rat
              Wound Healing in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

    Orthologs
    for CXCL6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL6 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    		 Uncharacterized protein
    		 32(a)
    		 1 → many
    		 4(52472071-52473367)


    ENSEMBL Gene Tree for CXCL6 (if available)
    TreeFam Gene Tree for CXCL6 (if available) 

    Paralogs
    for CXCL6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL6 gene
    CXCL32  CXCL52  PPBP2  PF42  CXCL12  PF4V12  IL82  CXCL22  
    12 SIMAP similar genes for CXCL6 using alignment to 2 protein entries:     CXCL6_HUMAN (see all proteins):
    CXCL5    IL8    CXCL3    CXCL1    CXCL2    PF4
    CXCL10    CXCL12    CXCL9    PF4V1    PPBP    CXCL13

    CXCL6 for paralogs           About GeneDecksing



    Genomic Variants
    for CXCL6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 NCBI SNPs in CXCL6 are shown (see all 99)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs76884851,2
    		C,A--74700367(+) AACATA/TCGTGT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1119035791,2
    		C--74700432(+) TGGGAC/TGGCTG 1 -- us2k10--------
    rs1923228371,2
    		--74700445(+) TCAAAC/TGGTAT 1 -- us2k10--------
    rs1814719331,2
    		--74700465(+) TAGATA/CCCTGA 1 -- us2k10--------
    rs623124151,2
    		C--74700530(+) AGTGTC/AAAAGT 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs361919221,2
    		C--74700541(+) GTTCCT/CATTTC 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1870626131,2
    		--74700733(+) CATCCA/GCTTTT 1 -- us2k10--------
    rs1910511871,2
    		--74700736(+) CCACTA/TTTTGA 1 -- us2k10--------
    rs1828083321,2
    		--74700761(+) TTTTTC/GTTGTA 1 -- us2k10--------
    rs119309781,2
    		C,A,H--74700826(+) GGTCGT/CGAAAA 1 -- us2k1 tfbs31Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for CXCL6 (74702214 - 74714781 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CXCL6: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CXCL6
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    Disorders / Diseases
    for CXCL6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CXCL6 for disorders           About GeneDecksing

    OMIM gene information: 138965    OMIM disorders: --

    20/32 diseases for CXCL6 (see all 32):    About MalaCards
    neural tube defect    wegener's granulomatosis    sleep apnea    cystic fibrosis lung disease
    cystic fibrosis    inflammatory bowel disease    pancreatic cystadenoma    rheumatoid arthritis
    apnea    tonsillitis    bronchiolitis    cystadenoma
    mastitis    arthritis    osteoarthritis    periodontitis
    uveitis    periodontal disease    fibrosis    crohn's disease

    10/16 Novoseek disease relationships for CXCL6 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 43.8 9 18842116 (2), 18782286 (1), 16305697 (1), 18443119 (1) (see all 6)
    osteosarcoma 40.6 8 9057843 (2), 9054580 (1), 9164944 (1), 9365109 (1) (see all 5)
    tonsillitis 38.8 4 15807854 (3)
    necrosis 19.3 2 12882792 (1), 12524079 (1)
    sinusitis 18.8 1 12744776 (1)
    pathological processes 12.7 3 12524079 (1), 12533683 (1)
    tumors 12.6 21 11583968 (4), 15652347 (2), 18578857 (2), 9057843 (1) (see all 10)
    neovascularization 9.79 1 15652347 (1)
    osteoarthritis 6.82 7 15292528 (3), 14707104 (1)
    asthma 0 1 16332507 (1)

    Genetic Association Database (GAD): CXCL6
    Human Genome Epidemiology (HuGE) Navigator: CXCL6 (7 documents)

    Export disorders for CXCL6 gene to outside databases

    Publications
    for CXCL6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL6 gene, integrated from 9 sources (see all 114):
    (articles sorted by number of sources associating them with CXCL6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell- derived neutrophil activating peptide-78 mRNAs. (PubMed id 9057843)1, 2, 9 Froyen G.... Billiau A. (1997)
    2. Cloning and characterization of the human granulocyte chemotactic protein-2 gene. (PubMed id 9164944)1, 2, 9 Rovai L.E.... Smith J.B. (1997)
    3. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)1, 2, 9 Proost P....van Damme J. (1993)
    4. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. (PubMed id 8399143)1, 2, 9 Proost P.... van Damme J. (1993)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids. (PubMed id 9465307)1, 3 Modi W.S. and Chen Z.Q. (1998)
    8. The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma: comparison with interleukin-8/CXCL8. (PubMed id 12533683)1, 9 Wuyts A....Van Damme J. (2003)
    9. Granulocyte chemotactic protein 2 (gcp-2/cxcl6) compl ements interleukin-8 in periodontal disease. (PubMed id 18842116)1, 9 Kebschull M....Papapanou P.N. (2009)
    10. Secretion of granulocyte chemotactic protein-2 by cultured human endometrial stromal cells. (PubMed id 12524079)1, 9 Mine S....Miyakawa I. (2003)

    External Searches for CXCL6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing CXCL6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6372 HGNC: 10643 AceView: CXCL6 Ensembl:ENSG00000124875 euGenes: HUgn6372
    ECgene: CXCL6 Kegg: 6372 H-InvDB: CXCL6

    Other Databases showing CXCL6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXCL6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL6 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXCL6

    Intellectual Property
    for CXCL6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CXCL6 gene:
    Search GeneIP for patents involving CXCL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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