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CXCL6 Gene

protein-coding GIFtS: 57
GCID: GC04P074691

Chemokine (C-X-C Motif) Ligand 6

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbol: SCYB6)

Microbiology & Infectious Diseases Congress

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-X-C Motif) Ligand 6¹ ²		Chemokine Alpha 3² ³
SCYB6¹ ² ³ ⁵		Small-Inducible Cytokine B6² ³
Granulocyte Chemotactic Protein 2¹ ² ³		CKA-3² ³
GCP2² ³ ⁵		GCP-2² ³
Chemokine (C-X-C Motif) Ligand 6 (Granulocyte Chemotactic Protein 2)¹ ²		C-X-C Motif Chemokine 6²
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 6 (Granulocyte Chemotactic Protein 2)¹ ²		Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member B²

External Ids:	HGNC: 10643¹	Entrez Gene: 6372²	Ensembl: ENSG00000124875⁷	OMIM: 138965⁵	UniProtKB: P80162³

ORGUL members:

Export aliases for CXCL6 gene to outside databases

Previous GC identifers: GC04P074942 GC04P075102 GC04P075168 GC04P075067 GC04P074921 GC04P070513

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CXCL6 Gene:

CXCL6 (chemokine (C-X-C motif) ligand 6) is a protein-coding gene. Diseases associated with CXCL6 include pancreatic cystadenoma, and tonsillitis. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162

Function: Chemotactic for neutrophil granulocytes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000004.12 NC_018915.2 NT_016354.20

Regulatory elements:

Regulatory transcription factor binding sites in the CXCL6 gene promoter:
SRF RFX1 Pbx1a MEF-2 SRF (504 AA) Lmo2 AP-4 MEF-2A aMEF-2 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL6 promoter sequence

Search Chromatin IP Primers for CXCL6

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3

CXCL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL6 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P074691: view genomic region (about GC identifiers)

Start:	74,702,214 bp from pter	End:	74,714,781 bp from pter
Size:	12,568 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162 (See protein sequence)

Recommended Name: C-X-C motif chemokine 6 precursor

Size: 114 amino acids; 11897 Da

Secondary accessions: B2R4X3 Q4W5D4

Explore the universe of human proteins at neXtProt for CXCL6: NX_P80162

Explore proteomics data for CXCL6 at MOPED

See CXCL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002984.1

ENSEMBL proteins:

ENSP00000226317 ENSP00000424819

Reactome Protein details: P80162

CXCL6 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CXCL6 (CXCL6/GCP-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for CXCL6 OriGene Custom MassSpec OriGene Custom Protein Services for CXCL6
	GenScript Custom Purified and Recombinant Proteins Services for CXCL6
	Novus Biologicals CXCL6 Proteins Novus Biologicals CXCL6 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

CXCL6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CXCL6 (CXCL6/GCP-2)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CXCL6
	Novus Biologicals CXCL6 Antibodies
	Abcam antibodies for CXCL6
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CXCL6
	LSBio Antibodies in human, mouse, rat for CXCL6

CXCL6 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CXCL6
	R&D Systems ELISAs for CXCL6 (CXCL6/GCP-2)
	GenScript Custom Assay Services for CXCL6
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ENDOLIG: Endogenous ligands

3 InterPro protein domains:

IPR001811 Chemokine_IL8-like_dom

IPR001089 Chemokine_CXC

IPR018048 Chemokine_CXC_CS

Graphical View of Domain Structure for InterPro Entry P80162

ProtoNet protein and cluster: P80162

1 Blocks protein domain: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

CXCL6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CXCL6_HUMAN, P80162

Function: Chemotactic for neutrophil granulocytes

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	IEA	--
GO:0008201	heparin binding	IEA	--

CXCL6 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cxcl5):

hematopoietic system

homeostasis/metabolism

immune system

mortality/aging

CXCL6 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Cxcl5^tm1Gscw for CXCL6

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCL6

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCL6

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL6

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL6

miRNA Products:		miRTarBase miRNAs that target CXCL6: hsa-mir-26b-5p (MIRT029714)

		Block miRNA regulation of human, mouse, rat CXCL6 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CXCL6 (see all 9):
		hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: CXCL6 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CXCL6
		Predesigned siRNA for gene silencing in human, mouse, rat CXCL6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CXCL6

Clone Products:		OriGene clones in human, mouse for CXCL6 (see all 6) OriGene ORF clones in mouse, rat for CXCL6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
		Sino Biological Human cDNA Clone for CXCL6
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL6
		Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CXCL6_HUMAN, P80162: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
cytoskeleton	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

CXCL6 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CXCL6 About (see all 12)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

PEDF Induced Signaling

MIF Regulation of Innate Immune Cells	0.94	IL-6 Pathway	0.61
MIF Mediated Glucocorticoid Regulation	0.94	STAT3 Pathway	0.47
PEDF Induced Signaling	0.73	Endothelin-1 Signaling Pathway	0.46
all-trans-Retinoic Acid Signaling in Brain	0.71	Cytokine-cytokine receptor interaction	0.43

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Chemokine receptors bind chemokines

0.81

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

0.81

Chemokine Signaling

Chemokine signaling pathway

0.33

Chemokine Signaling

0.33

Peptide ligand-binding receptors

	Class A/1 (Rhodopsin-like receptors)	0.71			Peptide ligand-binding receptors	0.60
	GPCR ligand binding	0.71			G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for CXCL6

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL6 (see all 17)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

2 GeneGo (Thomson Reuters) Pathways for CXCL6

	Cytokine production by Th17 cells in CF (Mouse model)
	Cytokine production by Th17 cells in CF

2 Reactome Pathways for CXCL6

	Chemokine receptors bind chemokines
	G alpha (i) signalling events

4 Kegg Pathways (Kegg details for CXCL6):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Pertussis
	Rheumatoid arthritis

CXCL6 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including CXCL6 (see all 9):

Angiogenic Growth Factors in human mouse rat

Wound Healing in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Angiogenesis in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

GeneGlobe Interaction Network for CXCL6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CXCL6 (P80162³ ENSP00000226317⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 154)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CXCR2	P25025³, ENSP00000319635⁴	I2D: score=2 STRING: ENSP00000319635
MMP9	P14780³, ENSP00000361405⁴	I2D: score=2 STRING: ENSP00000361405
CXCR1	P25024³, ENSP00000295683⁴	I2D: score=2 STRING: ENSP00000295683
MMP1	P03956³	I2D: score=1
MMP12	P39900³	I2D: score=1

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Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	TAS	9164944
GO:0006954	inflammatory response	TAS	8399143
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	TAS	9164944
GO:0007267	cell-cell signaling	TAS	9164944

CXCL6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CXCL6

8 Novoseek inferred chemical compound relationships for CXCL6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
grogamma	88.9	4	15832427 (2), 9054580 (1), 19594487 (1)
grobeta	87.8	9	15292528 (3), 15832427 (2), 19594487 (1)
groalpha	85.5	10	10540194 (2), 18174342 (2), 9054580 (1), 9365109 (1) (see all 6)
rantes	55.2	8	9516414 (3), 14707104 (2), 8805659 (1), 18290317 (1) (see all 5)
calcium	12.6	10	9057843 (1), 10570306 (1), 15476666 (1), 17699811 (1) (see all 8)
vegf	4.51	5	16332507 (3), 16377203 (1), 18290317 (1)
oxygen	0	1	16721367 (1)
serine	0	1	9516414 (1)

CXCL6 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CXCL6 gene:

NM_002993.3

Unigene Cluster for CXCL6:

Chemokine (C-X-C motif) ligand 6

Hs.164021 [show with all ESTs]

Unigene Representative Sequence: NM_002993

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000226317(uc003hhf.3) ENST00000515050 ENST00000503446

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat CXCL6 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CXCL6 (see all 9):
		hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: CXCL6 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CXCL6
		Predesigned siRNA for gene silencing in human, mouse, rat CXCL6

Clone Products:		OriGene clones in human, mouse for CXCL6 (see all 6) OriGene ORF clones in mouse, rat for CXCL6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6

Primer Products:		OriGene qPCR primer pairs and template standards for CXCL6 OriGene qSTAR qPCR primer pairs in human, mouse for CXCL6
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CXCL6
		QuantiTect SYBR Green Assays in human, mouse, rat CXCL6
		QuantiFast Probe-based Assays in human, mouse, rat CXCL6

Additional mRNA sequence:

AK311981.1 BC013744.1 U81234.1 Y08770.1

2 DOTS entries:

DT.70104493 DT.121258772

Selected AceView cDNA sequences (see all 59):

AU102795 CR614096 CB112103 BP338870 BM994397 AU098540 BQ717848 BP336724

CR623302 AW515797 AU076718 BX380732 CA420646 CB853166 BQ694209 BU942618

BP337169 BC013744 BG253033 BP336399 BG122200 BP335241 BX395981 AI668847

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXCL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTGGTTTTTG

About this image

CXCL6 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 9) fully expand


Neural Crest (Gastrulation Derivatives) fully expand to see all 3 entries
PureStem 4D20.8, NCr-fac Progenitor

Liver (Hepatobiliary System)
Liver Lobule

Mesoderm (Gastrulation Derivatives)
PureStem 7SMOO32, NCr-fac & Meso Progenitor

Heart (Cardiovascular System)
Mature Cardiac Fibroblasts Myocardium

Paraxial Mesoderm (Gastrulation Derivatives)
PureStem 7PEND24, NCr-fac & Meso-prx Progenitor

CXCL6 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CXCL6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.164021

Pathway & Disease-focused RT² Profiler PCR Arrays including CXCL6 (see all 9):

Angiogenic Growth Factors in human mouse rat

Wound Healing in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Angiogenesis in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CXCL6 OriGene qSTAR qPCR primer pairs in human, mouse for CXCL6
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CXCL6
		QuantiTect SYBR Green Assays in human, mouse, rat CXCL6
		QuantiFast Probe-based Assays in human, mouse, rat CXCL6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CXCL6 gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cxcl5^{1 , 5}	chemokine (C-X-C motif) ligand 5^{1, 5}	71.43(n)¹ 64.94(a)¹		5 (44.78 cM)⁵ 20311¹ NM_009141.3¹ NP_033167.2¹ 90759299⁵
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	33(a)	1 → many	4(50379773-50381069)
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	37(a)	1 → many	6(60123888-60134622)

ENSEMBL Gene Tree for CXCL6 (if available)
TreeFam Gene Tree for CXCL6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CXCL6 gene

PPBP² PF4² CXCL1² PF4V1² CXCL3² CXCL5² CXCL2² IL8²

12 SIMAP similar genes for CXCL6 using alignment to 2 protein entries: CXCL6_HUMAN (see all proteins):

CXCL5 IL8 CXCL3 CXCL1 CXCL2 PF4

CXCL10 CXCL12 CXCL9 PF4V1 PPBP CXCL13

CXCL6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7688485^1,2	C,A	--	74700367(+)	`aacatA/Tcgtgt`	1	--	us2k¹		1		NA	2
rs111903579^1,2	C	--	74700432(+)	`TGGGAC/TGGCTG`	1	--	us2k¹		0	--	--	--	--
rs192322837^1,2		--	74700445(+)	`TCAAAC/TGGTAT`	1	--	us2k¹		0	--	--	--	--
rs181471933^1,2		--	74700465(+)	`TAGATA/CCCTGA`	1	--	us2k¹		0	--	--	--	--
rs62312415^1,2	C	--	74700530(+)	`AGTGTC/AAAAGT`	1	--	us2k¹		1		NA	2
rs36191922^1,2	C	--	74700541(+)	`GTTCCT/CATTTC`	1	--	us2k¹		1		NA	2
rs187062613^1,2		--	74700733(+)	`CATCCA/GCTTTT`	1	--	us2k¹		0	--	--	--	--
rs191051187^1,2		--	74700736(+)	`CCACTA/TTTTGA`	1	--	us2k¹		0	--	--	--	--
rs182808332^1,2	C	--	74700761(+)	`TTTTTC/GTTGTA`	1	--	us2k¹		0	--	--	--	--
rs11930978^1,2	C,A,H	--	74700826(+)	`ggtcgT/Cgaaaa`	1	--	us2k¹ tfbs³		1		NA	2

HapMap Linkage Disequilibrium report for CXCL6 (74702214 - 74714781 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for CXCL6: About this table

Variant ID	Type	Subtype	PubMed ID
nsv4389	CNV	Insertion	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CXCL6

DNA2.0 Custom Variant and Variant Library Synthesis for CXCL6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 138965 OMIM disorders: --

Selected diseases for CXCL6 (see all 34):
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pancreatic cystadenoma tonsillitis mastitis sleep apnea

cystadenoma pertussis wegener's granulomatosis sinusitis

neural tube defects osteosarcoma sepsis periodontal disease

uveitis bronchiolitis periodontitis peritonitis

rheumatoid arthritis arthritis endometriosis crohn's disease

CXCL6 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Selected Novoseek inferred disease relationships for CXCL6 gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	43.8	9	18842116 (2), 18782286 (1), 16305697 (1), 18443119 (1) (see all 6)
osteosarcoma	40.6	8	9057843 (2), 9054580 (1), 9164944 (1), 9365109 (1) (see all 5)
tonsillitis	38.8	4	15807854 (3)
necrosis	19.3	2	12882792 (1), 12524079 (1)
sinusitis	18.8	1	12744776 (1)
pathological processes	12.7	3	12524079 (1), 12533683 (1)
tumors	12.6	21	11583968 (4), 15652347 (2), 18578857 (2), 9057843 (1) (see all 10)
neovascularization	9.79	1	15652347 (1)
osteoarthritis	6.82	7	15292528 (3), 14707104 (1)
asthma	0	1	16332507 (1)

Genetic Association Database (GAD): CXCL6
Human Genome Epidemiology (HuGE) Navigator: CXCL6 (7 documents)

Export disorders for CXCL6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CXCL6 gene, integrated from 10 sources (see all 116):
(articles sorted by number of sources associating them with CXCL6)

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Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell- derived neutrophil activating peptide-78 mRNAs. (PubMed id 9057843)^{1, 2, 9} Froyen G.... Billiau A. (Eur. J. Biochem. 1997)
Cloning and characterization of the human granulocyte chemotactic protein-2 gene. (PubMed id 9164944)^{1, 2, 9} Rovai L.E.... Smith J.B. (J. Immunol. 1997)
Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)^{1, 2, 9} Proost P....van Damme J. (J. Immunol. 1993)
Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. (PubMed id 8399143)^{1, 2, 9} Proost P.... van Damme J. (Biochemistry 1993)
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (PLoS Genet. 2010)
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (Gut 2009)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)^{1, 4} Hillian A.D....Drumm M.L. (Genes Immun. 2008)
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (J. Infect. Dis. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6372	HGNC: 10643	AceView: CXCL6	Ensembl:ENSG00000124875	euGenes: HUgn6372
ECgene: CXCL6	Kegg: 6372	H-InvDB: CXCL6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CXCL6	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CXCL6

Intellectual Property for CXCL6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CXCL6 gene:
Search GeneIP for patents involving CXCL6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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CXCL6 Gene

Chemokine (C-X-C Motif) Ligand 6

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Chemokine (C-X-C Motif) Ligand 6

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