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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CXCL6 Gene

protein-coding   GIFtS: 57
GCID: GC04P074691

Chemokine (C-X-C Motif) Ligand 6

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbol: SCYB6)
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Aliases
for CXCL6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Chemokine (C-X-C Motif) Ligand 61 2     Chemokine Alpha 32 3
SCYB61 2 3 5     Small-Inducible Cytokine B62 3
Granulocyte Chemotactic Protein 21 2 3     CKA-32 3
GCP22 3 5     GCP-22 3
Chemokine (C-X-C Motif) Ligand 6 (Granulocyte Chemotactic Protein 2)1 2     C-X-C Motif Chemokine 62
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 6 (Granulocyte
Chemotactic Protein 2)1 2
     Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member B2

External Ids:    HGNC: 106431   Entrez Gene: 63722   Ensembl: ENSG000001248757   OMIM: 1389655   UniProtKB: P801623   

Export aliases for CXCL6 gene to outside databases

Previous GC identifers: GC04P074942 GC04P075102 GC04P075168 GC04P075067 GC04P074921 GC04P070513


Summaries
for CXCL6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for CXCL6 Gene: 
CXCL6 (chemokine (C-X-C motif) ligand 6) is a protein-coding gene. Diseases associated with CXCL6 include pancreatic cystadenoma, and mastitis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include heparin binding and chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162
Function: Chemotactic for neutrophil granulocytes




Genomic Views
for CXCL6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXCL6 gene promoter:
         SRF   RFX1   Pbx1a   MEF-2   SRF (504 AA)   Lmo2   AP-4   MEF-2A   aMEF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CXCL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CXCL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CXCL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

CXCL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074691:  view genomic region     (about GC identifiers)

Start:
 74,702,214 bp from pter      End:
 74,714,781 bp from pter
Size:
 12,568 bases      Orientation:
 plus strand

Proteins
for CXCL6 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162 (See protein sequence)
Recommended Name: C-X-C motif chemokine 6 precursor  
Size: 114 amino acids; 11897 Da
Subcellular location: Secreted
Secondary accessions: B2R4X3 Q4W5D4

Explore the universe of human proteins at neXtProt for CXCL6: NX_P80162

Explore proteomics data for CXCL6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P80162

    • CXCL6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CXCL6 Protein Expression
    REFSEQ proteins: NP_002984.1  
    ENSEMBL proteins: 
     ENSP00000226317   ENSP00000424819  
    Reactome Protein details: P80162
    Human Recombinant Protein Products for CXCL6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CXCL6 (CXCL6/GCP-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CXCL6
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CXCL6
    GenScript Custom Purified and Recombinant Proteins Services for CXCL6
    Novus Biologicals CXCL6 Proteins
    Novus Biologicals CXCL6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CXCL6 for ontologies           About GeneDecksing



    CXCL6 Antibody Products: 
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    Novus Biologicals CXCL6 Antibodies
    Abcam antibodies for CXCL6
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CXCL6
    LSBio Antibodies in human, mouse, rat for CXCL6 

    Assay Products for CXCL6: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CXCL6 (CXCL6/GCP-2)
    GenScript Custom Assay Services for CXCL6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.

    Protein Domains /
    Families
    for CXCL6 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P80162

    ProtoNet protein and cluster: P80162

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXCL6_HUMAN, P80162
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    CXCL6 for domains           About GeneDecksing


    Function
    for CXCL6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCL6_HUMAN, P80162
    Function: Chemotactic for neutrophil granulocytes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--
    GO:0008201heparin binding IEA--
         
    CXCL6 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cxcl5):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    CXCL6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cxcl5tm1Gscw for CXCL6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CXCL6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CXCL6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL6 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL6
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL6 (see all 9):
    hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CXCL6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CXCL6
    Sirion Biotech Customized adenovirus for overexpression of CXCL6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CXCL6 (see all 7)
    OriGene ORF clones in mouse, rat for CXCL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
    Sino Biological Human cDNA Clone for CXCL6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6
    Sirion Biotech Customized lentivirus for stable overexpression of CXCL6 
                         Customized lentivirus expression plasmids for stable overexpression of CXCL6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CXCL6
    Search LifeMap BioReagents cell lines for CXCL6
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6


    Pathways & Interactions
    for CXCL6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CXCL6 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    		MIF Mediated Glucocorticoid Regulation0.94
    		IL-6 Pathway0.61
    		MIF Regulation of Innate Immune Cells0.94
    		STAT3 Pathway0.47
    		PEDF Induced Signaling0.73
    		Endothelin-1 Signaling Pathway0.46
    		all-trans-Retinoic Acid Signaling in Brain0.71
    		Cytokine-cytokine receptor interaction0.43
    2Chemokine Signaling
    		Chemokine Signaling0.33
    		Chemokine signaling pathway0.33
    3Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)0.71
    		Peptide ligand-binding receptors0.60
    		GPCR ligand binding0.71
    		G alpha (i) signalling events0.46
    4Signaling by GPCR
    		Signaling by GPCR0.90
    		Signal Transduction0.55
    		GPCR downstream signaling0.90
    5Rho Family GTPases
    		Rho Family GTPases0.61
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CXCL6 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation

    2 GeneGo (Thomson Reuters) Pathways for CXCL6
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF


    5/8        Reactome Pathways for CXCL6 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    4         Kegg Pathways  (Kegg details for CXCL6):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Pertussis
    Rheumatoid arthritis


    CXCL6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXCL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/154 Interacting proteins for CXCL6 (P801623 ENSP000002263174) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250253, ENSP000003196354I2D: score=2 STRING: ENSP00000319635
    MMP9P147803, ENSP000003614054I2D: score=2 STRING: ENSP00000361405
    CXCR1P250243, ENSP000002956834I2D: score=2 STRING: ENSP00000295683
    MMP1P039563I2D: score=1 
    MMP12P399003I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response TAS8399143
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS9164944
    GO:0007267cell-cell signaling TAS9164944

    CXCL6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CXCL6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CXCL6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXCL6

    8 Novoseek inferred chemical compound relationships for CXCL6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grogamma 88.9 4 15832427 (2), 9054580 (1), 19594487 (1)
    grobeta 87.8 9 15292528 (3), 15832427 (2), 19594487 (1)
    groalpha 85.5 10 10540194 (2), 18174342 (2), 9054580 (1), 9365109 (1) (see all 6)
    rantes 55.2 8 9516414 (3), 14707104 (2), 8805659 (1), 18290317 (1) (see all 5)
    calcium 12.6 10 9057843 (1), 10570306 (1), 15476666 (1), 17699811 (1) (see all 8)
    vegf 4.51 5 16332507 (3), 16377203 (1), 18290317 (1)
    oxygen 0 1 16721367 (1)
    serine 0 1 9516414 (1)

    Search CenterWatch for drugs/clinical trials and news about CXCL6

    Transcripts
    for CXCL6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CXCL6 gene: 
    NM_002993.3  

    Unigene Cluster for CXCL6:

    Chemokine (C-X-C motif) ligand 6
    Hs.164021  [show with all ESTs]
    Unigene Representative Sequence: NM_002993
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226317(uc003hhf.3) ENST00000515050 ENST00000503446
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CXCL6
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CXCL6 (see all 9):
    hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: CXCL6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CXCL6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CXCL6
    Clone
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    OriGene ORF clones in mouse, rat for CXCL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6
    Sirion Biotech Customized lentivirus for stable overexpression of CXCL6 
                         Customized lentivirus expression plasmids for stable overexpression of CXCL6 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CXCL6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL6

    Additional mRNA sequence: 

    AK311981.1 BC013744.1 U81234.1 Y08770.1 

    2 DOTS entries:

    DT.70104493  DT.121258772 

    24/59 AceView cDNA sequences (see all 59):

    AU098540 CR614096 AU102795 BQ717848 CR623302 BP336724 BP338870 AU076718 
    AW515797 BM994397 CB112103 BI837528 U81234 CA420646 BI768679 AI391519 
    BG122844 BP337255 BP335241 CB529862 AI860457 BU677384 BP335443 BP337169 

    GeneLoc Exon Structure


    Expression
    for CXCL6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CXCL6 expression in normal human tissues (normalized intensities)      CXCL6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTTTTTG
    CXCL6 Expression
    About this image


    CXCL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem progenitor F15
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Mature Cardiac Fibroblasts Myocardium
             Coronary Artery Smooth Muscle Cells (CASMC)   
             Cardiac Myocytes   
     
     Fibroblast
             Human Ovarian Fibroblasts (HOF)   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Human Hepatic Stellate Cells (HHSteC)   

    See CXCL6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CXCL6

    SOURCE GeneReport for Unigene cluster: Hs.164021
        SABiosciences Expression via Pathway-Focused PCR Arrays including CXCL6 (see all 9): 
              Angiogenic Growth Factors in human mouse rat
              Wound Healing in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL6
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CXCL6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

    Orthologs
    for CXCL6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL6 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cxcl51 , 5 chemokine (C-X-C motif) ligand 51, 5 69.07(n)1
    62.16(a)1    		   5 (44.78 cM)5
    203111  NM_009141.21  NP_033167.21 
     907592995 
    chicken
    (Gallus gallus)    		 Aves --
    		 Uncharacterized protein
    		 29(a)
    		 possible ortholog
    		 4(50379773-50381069)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 35(a)
    		 possible ortholog
    		 6(60123888-60134622)


    ENSEMBL Gene Tree for CXCL6 (if available)
    TreeFam Gene Tree for CXCL6 (if available)

    Paralogs
    for CXCL6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CXCL6 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL32  CXCL52  CXCL22  IL82  
    12 SIMAP similar genes for CXCL6 using alignment to 2 protein entries:     CXCL6_HUMAN (see all proteins):
    CXCL5    IL8    CXCL3    CXCL1    CXCL2    PF4
    CXCL10    CXCL12    CXCL9    PF4V1    PPBP    CXCL13

    CXCL6 for paralogs           About GeneDecksing



    Genomic Variants
    for CXCL6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/125 SNPs in CXCL6 are shown (see all 125)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs76884851,2
    		C,A--74700367(+) aacatA/Tcgtgt 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1119035791,2
    		C--74700432(+) TGGGAC/TGGCTG 1 -- us2k10--------
    rs1923228371,2
    		--74700445(+) TCAAAC/TGGTAT 1 -- us2k10--------
    rs1814719331,2
    		--74700465(+) TAGATA/CCCTGA 1 -- us2k10--------
    rs623124151,2
    		C--74700530(+) AGTGTC/AAAAGT 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs361919221,2
    		C--74700541(+) GTTCCT/CATTTC 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1870626131,2
    		--74700733(+) CATCCA/GCTTTT 1 -- us2k10--------
    rs1910511871,2
    		--74700736(+) CCACTA/TTTTGA 1 -- us2k10--------
    rs1828083321,2
    		C--74700761(+) TTTTTC/GTTGTA 1 -- us2k10--------
    rs119309781,2
    		C,A,H--74700826(+) ggtcgT/Cgaaaa 1 -- us2k1 tfbs31Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for CXCL6 (74702214 - 74714781 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCL6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4389CNV Insertion18451855

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    Disorders / Diseases
    for CXCL6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 138965    OMIM disorders: --

    20/30 diseases for CXCL6 (see all 30):    About MalaCards
    pancreatic cystadenoma    mastitis    tonsillitis    sleep apnea
    wegener's granulomatosis    cystadenoma    pertussis    neural tube defects
    cystic fibrosis    osteosarcoma    periodontal disease    uveitis
    bronchiolitis    peritonitis    periodontitis    sinusitis
    crohn's disease    endometriosis    rheumatoid arthritis    arthritis


    CXCL6 for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for CXCL6 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 43.8 9 18842116 (2), 18782286 (1), 16305697 (1), 18443119 (1) (see all 6)
    osteosarcoma 40.6 8 9057843 (2), 9054580 (1), 9164944 (1), 9365109 (1) (see all 5)
    tonsillitis 38.8 4 15807854 (3)
    necrosis 19.3 2 12882792 (1), 12524079 (1)
    sinusitis 18.8 1 12744776 (1)
    pathological processes 12.7 3 12524079 (1), 12533683 (1)
    tumors 12.6 21 11583968 (4), 15652347 (2), 18578857 (2), 9057843 (1) (see all 10)
    neovascularization 9.79 1 15652347 (1)
    osteoarthritis 6.82 7 15292528 (3), 14707104 (1)
    asthma 0 1 16332507 (1)

    Genetic Association Database (GAD): CXCL6
    Human Genome Epidemiology (HuGE) Navigator: CXCL6 (7 documents)

    Export disorders for CXCL6 gene to outside databases

    Publications
    for CXCL6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CXCL6 gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with CXCL6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell- derived neutrophil activating peptide-78 mRNAs. (PubMed id 9057843)1, 2, 9 Froyen G.... Billiau A. (1997)
    2. Cloning and characterization of the human granulocyte chemotactic protein-2 gene. (PubMed id 9164944)1, 2, 9 Rovai L.E.... Smith J.B. (1997)
    3. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)1, 2, 9 Proost P....van Damme J. (1993)
    4. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. (PubMed id 8399143)1, 2, 9 Proost P.... van Damme J. (1993)
    5. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    7. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    9. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)1, 4 Hillian A.D....Drumm M.L. (2008)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)

    External Searches for CXCL6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CXCL6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6372 HGNC: 10643 AceView: CXCL6 Ensembl:ENSG00000124875 euGenes: HUgn6372
    ECgene: CXCL6 Kegg: 6372 H-InvDB: CXCL6

    Other Databases showing CXCL6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXCL6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CXCL6 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXCL6

    Intellectual Property
    for CXCL6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CXCL6 gene:
    Search GeneIP for patents involving CXCL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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