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CXCL6 Gene(Protein Coding)

C-X-C Motif Chemokine Ligand 6

GCID:
GC04P073837
GIFtS:
58
Genes Participants
UDN Logo

Aliases for CXCL6 Gene

Aliases for CXCL6 Gene

  • C-X-C Motif Chemokine Ligand 6 2 3 5
  • Granulocyte Chemotactic Protein 2 2 3 4
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 6 (Granulocyte Chemotactic Protein 2) 2 3
  • Chemokine (C-X-C Motif) Ligand 6 (Granulocyte Chemotactic Protein 2) 2 3
  • Small-Inducible Cytokine B6 3 4
  • Chemokine Alpha 3 3 4
  • SCYB6 3 4
  • CKA-3 3 4
  • GCP-2 3 4
  • GCP2 3 4
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member B 3
  • Chemokine (C-X-C Motif) Ligand 6 2
  • C-X-C Motif Chemokine 6 3

External Ids for CXCL6 Gene

Previous HGNC Symbols for CXCL6 Gene

  • SCYB6

Previous GeneCards Identifiers for CXCL6 Gene

  • GC04P074691
  • GC04P074942
  • GC04P075102
  • GC04P075168
  • GC04P075067
  • GC04P074921
  • GC04P070513

Summaries for CXCL6 Gene

GeneCards Summary for CXCL6 Gene

CXCL6 (C-X-C Motif Chemokine Ligand 6) is a Protein Coding gene. Diseases associated with CXCL6 include Mastitis and Rheumatoid Arthritis. Among its related pathways are Peptide ligand-binding receptors and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. GO annotations related to this gene include heparin binding and CXCR chemokine receptor binding. An important paralog of this gene is CXCL5.

UniProtKB/Swiss-Prot for CXCL6 Gene

  • Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL6 Gene

Genomics for CXCL6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CXCL6 Gene

Enhancers for CXCL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G073727 1.1 Ensembl ENCODE dbSUPER 4.9 -108.4 -108406 1.0 STAT1 SMAD5 CEBPB CEBPG IRF9 ZNF316 ZNF366 IKZF1 ZNF512 PF4V1 CXCL6 CXCL8 LOC105377272
GH04G073674 1.1 ENCODE dbSUPER 4.7 -160.3 -160278 3.7 PKNOX1 RFX5 TCF12 SCRT2 RCOR1 RELB KLF13 IKZF2 CEBPB ZEB2 PF4V1 CXCL8 CXCL6 RASSF6 LOC105377272
GH04G073672 0.8 dbSUPER 4.7 -163.1 -163143 1.6 SOX13 FOXA2 CEBPG ZNF644 YY1 GATA2 SCRT2 TRIM24 FOS HOMEZ PF4V1 CXCL8 MTHFD2L RASSF6 CXCL6 LOC105377272
GH04G073762 0.6 FANTOM5 4.6 -73.8 -73833 0.2 IKZF1 FOS SPI1 CXCL8 PF4V1 CXCL6 PPBP PF4 GC04P073743 ENSG00000249051
GH04G073822 0.5 FANTOM5 5.4 -13.4 -13363 0.3 ZNF316 EMSY MAFK CXCL8 CXCL3 PF4V1 CXCL2 CXCL6 MTHFD2L ENSG00000249051
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXCL6 on UCSC Golden Path with GeneCards custom track

Promoters for CXCL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000169240 203 601 MAZ RBBP5 ZIC2 ZBTB48 POLR2A ZBTB33 ZNF600 ZBTB26 ZBTB20

Transcription factor binding sites by QIAGEN in the CXCL6 gene promoter:

Genomic Location for CXCL6 Gene

Chromosome:
4
Start:
73,836,497 bp from pter
End:
73,849,064 bp from pter
Size:
12,568 bases
Orientation:
Plus strand

Genomic View for CXCL6 Gene

Genes around CXCL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CXCL6 Gene

Proteins for CXCL6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CXCL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80162-CXCL6_HUMAN
    Recommended name:
    C-X-C motif chemokine 6
    Protein Accession:
    P80162
    Secondary Accessions:
    • B2R4X3
    • Q4W5D4

    Protein attributes for CXCL6 Gene

    Size:
    114 amino acids
    Molecular mass:
    11897 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL6 Gene

Protein Expression for CXCL6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CXCL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CXCL6
  • Cloud-Clone Corp. Antibodies for CXCL6
  • Santa Cruz Biotechnology (SCBT) Antibodies for CXCL6

No data available for DME Specific Peptides for CXCL6 Gene

Domains & Families for CXCL6 Gene

Gene Families for CXCL6 Gene

HGNC:

Protein Domains for CXCL6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80162

UniProtKB/Swiss-Prot:

CXCL6_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL6: view

Function for CXCL6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CXCL6 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).

Gene Ontology (GO) - Molecular Function for CXCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IEA,IDA 8399143
GO:0008201 heparin binding IEA --
GO:0045236 CXCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CXCL6: view
genes like me logo Genes that share phenotypes with CXCL6: view

Animal Models for CXCL6 Gene

MGI Knock Outs for CXCL6:

Animal Model Products

CRISPR Products

miRNA for CXCL6 Gene

miRTarBase miRNAs that target CXCL6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL6 Gene

Localization for CXCL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL6 gene
Compartment Confidence
extracellular 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CXCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IBA,IEA --
genes like me logo Genes that share ontologies with CXCL6: view

Pathways & Interactions for CXCL6 Gene

genes like me logo Genes that share pathways with CXCL6: view

Gene Ontology (GO) - Biological Process for CXCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002446 neutrophil mediated immunity IBA --
GO:0006935 chemotaxis IEA,TAS 9164944
GO:0006952 defense response IEA --
GO:0006954 inflammatory response TAS --
GO:0006955 immune response IEA,IBA --
genes like me logo Genes that share ontologies with CXCL6: view

No data available for SIGNOR curated interactions for CXCL6 Gene

Drugs & Compounds for CXCL6 Gene

Products:

  1. Drug

(3) Drugs for CXCL6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for CXCL6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL6: view

Transcripts for CXCL6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CXCL6 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL6 Gene

Chemokine (C-X-C motif) ligand 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL6 Gene

No ASD Table

Relevant External Links for CXCL6 Gene

GeneLoc Exon Structure for
CXCL6
ECgene alternative splicing isoforms for
CXCL6

Expression for CXCL6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL6 Gene

mRNA expression in normal human tissues for CXCL6 Gene
mRNA expression by BioGPS for CXCL6 GenemRNA expression by GTEx for CXCL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL6 Gene

This gene is overexpressed in Spleen (x21.1).

Protein differential expression in normal tissues from HIPED for CXCL6 Gene

This gene is overexpressed in Islet of Langerhans (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL6 Gene



Protein tissue co-expression partners for CXCL6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL6 Gene:

CXCL6

SOURCE GeneReport for Unigene cluster for CXCL6 Gene:

Hs.164021

Evidence on tissue expression from TISSUES for CXCL6 Gene

  • Spleen(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with CXCL6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL6 Gene

Orthologs for CXCL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CXCL6 34 35
  • 98.83 (n)
cow
(Bos Taurus)
 Mammalia CXCL6 35
  • 74 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Cxcl5 34 16 35
  • 71.43 (n)
rat
(Rattus norvegicus)
 Mammalia Cxcl5 34
  • 69.3 (n)
dog
(Canis familiaris)
 Mammalia -- 35
  • 60 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 48 (a)
 ManyToMany
-- 35
  • 43 (a)
 ManyToMany
-- 35
  • 37 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 40 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves -- 35
  • 33 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 37 (a)
 OneToMany
Species where no ortholog for CXCL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL6 Gene

ENSEMBL:
Gene Tree for CXCL6 (if available)
TreeFam:
Gene Tree for CXCL6 (if available)

Paralogs for CXCL6 Gene

Paralogs for CXCL6 Gene

(12) SIMAP similar genes for CXCL6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CXCL6: view

Variants for CXCL6 Gene

Sequence variations from dbSNP and Humsavar for CXCL6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000312194 -- 73,838,086(+) CTTCT(A/C)ATAAA utr-variant-3-prime
rs1000491662 -- 73,838,494(+) TAACA(A/G)TGATC utr-variant-3-prime
rs1001466738 -- 73,837,358(+) CCTTA(C/T)TCTCT intron-variant
rs1001982796 -- 73,838,557(+) CATTT(A/G)GTCCT utr-variant-3-prime
rs1003761336 -- 73,836,397(+) AAGCC(C/G)AGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXCL6 Gene

Variant ID Type Subtype PubMed ID
nsv1001725 CNV gain 25217958
nsv1143412 CNV deletion 24896259
nsv1148833 CNV deletion 26484159
nsv4389 CNV insertion 18451855

Variation tolerance for CXCL6 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL6 Gene

Disorders for CXCL6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CXCL6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mastitis
  • breast inflammation
rheumatoid arthritis
  • rheumatoid arthritis, progression of
bardet-biedl syndrome 5
  • bbs5
- elite association - COSMIC cancer census association via MalaCards
Search CXCL6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCL6

Genetic Association Database (GAD)
CXCL6
Human Genome Epidemiology (HuGE) Navigator
CXCL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL6
genes like me logo Genes that share disorders with CXCL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL6 Gene

Publications for CXCL6 Gene

  1. The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial. (PMID: 18443119) Linge H.M. … Egesten A. (Antimicrob. Agents Chemother. 2008) 3 4 22 64
  2. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell- derived neutrophil activating peptide-78 mRNAs. (PMID: 9057843) Froyen G. … Billiau A. (Eur. J. Biochem. 1997) 3 4 22 64
  3. Cloning and characterization of the human granulocyte chemotactic protein-2 gene. (PMID: 9164944) Rovai L.E. … Smith J.B. (J. Immunol. 1997) 3 4 22 64
  4. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. (PMID: 8399143) Proost P. … van Damme J. (Biochemistry 1993) 3 4 22 64
  5. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PMID: 8423327) Proost P. … van Damme J. (J. Immunol. 1993) 3 4 22 64

Products for CXCL6 Gene

Sources for CXCL6 Gene

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