CXCL6 Gene

Aliases
for CXCL6 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC04P074942 GC04P075102 GC04P075168 GC04P075067 GC04P074921 GC04P070513

Summaries
for CXCL6 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CXCL6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000004.11  NC_018915.2  NT_016354.20  

SwitchGear Promoter luciferase reporter plasmid: CXCL6 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL6

CXCL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074691:  view genomic region     (about GC identifiers)

Proteins
for CXCL6 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CXCL6: NX_P80162

Explore proteomics data for CXCL6 at MOPED


See CXCL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

CXCL6 Human Recombinant Protein Products:

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	Novus Biologicals CXCL6 Proteins Novus Biologicals CXCL6 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CXCL6
	GeneTex Proteins for CXCL6:                       GCP-2 Recombinant Protein (Active) (GTX48141-PRO)
	antibodies-online proteins for CXCL6 (3 products)
	antibodies-online peptides for CXCL6

CXCL6 Antibody Products:

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	Abcam antibodies for CXCL6
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	ThermoFisher Antibodies for CXCL6
	antibodies-online antibodies for CXCL6 (15 products)

CXCL6 Assay Products:

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CXCL6
	antibodies-online kits for CXCL6 (9 products)

Domains /
Families
for CXCL6 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P80162

Find genes that share domains with CXCL6           About GenesLikeMe

Function
for CXCL6 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Cxcl5)

genOway: Develop your customized and physiologically relevant rodent model for CXCL6

miRNA Products:		miRTarBase miRNAs that target CXCL6: hsa-mir-26b-5p (MIRT029714)
		Block miRNA regulation of human, mouse, rat CXCL6 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CXCL6 (see all 9):
		hsa-miR-495 hsa-miR-7-2* hsa-miR-548o hsa-miR-3653 hsa-miR-3617 hsa-miR-641 hsa-miR-1323 hsa-miR-7-1*
		SwitchGear 3'UTR luciferase reporter plasmid: CXCL6 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CXCL6
		Predesigned siRNA for gene silencing in human, mouse, rat CXCL6

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CXCL6

Clone Products:		OriGene clones in human, mouse for CXCL6 (see all 6) OriGene ORF clones in mouse, rat for CXCL6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CXCL6 (NM_002993)
		Sino Biological Human cDNA Clone for CXCL6
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CXCL6
		Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

Localization
for CXCL6 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
cytoskeleton	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for CXCL6 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CXCL6 About   (see all 12)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	PEDF Induced Signaling	MIF Regulation of Innate Immune Cells 0.94 IL-6 Pathway 0.61 MIF Mediated Glucocorticoid Regulation 0.94 STAT3 Pathway 0.47 PEDF Induced Signaling 0.73 Endothelin-1 Signaling Pathway 0.46 all-trans-Retinoic Acid Signaling in Brain 0.71 Cytokine-cytokine receptor interaction 0.43
2	Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions	Chemokine receptors bind chemokines 0.81 Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 0.81
3	Chemokine Signaling	Chemokine Signaling 0.33 Chemokine signaling pathway 0.33
4	Peptide ligand-binding receptors	Class A/1 (Rhodopsin-like receptors) 0.71 Peptide ligand-binding receptors 0.60 GPCR ligand binding 0.71 G alpha (i) signalling events 0.44
5	Signaling by GPCR	Signaling by GPCR 0.90 Signal Transduction 0.58 GPCR downstream signaling 0.90

1 R&D Systems Pathway for CXCL6

Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL6

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Transendothelial Migration of Leukocytes
	MIF Mediated Glucocorticoid Regulation

2 GeneGo (Thomson Reuters) Pathways for CXCL6

	Cytokine production by Th17 cells in CF (Mouse model)
	Cytokine production by Th17 cells in CF

2 Reactome Pathways for CXCL6

	Chemokine receptors bind chemokines
	G alpha (i) signalling events

4 Kegg Pathways  (Kegg details for CXCL6)

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Pertussis
	Rheumatoid arthritis

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

Drugs & Compounds
for CXCL6 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CXCL6 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CXCL6 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CXCL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTGGTTTTTG

About this image

Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
PureStem 4D20.8, NCr-fac Progenitor
Liver (Hepatobiliary System)
Liver Lobule
Mesoderm (Gastrulation Derivatives)
PureStem 7SMOO32, NCr-fac & Meso Progenitor
Heart (Cardiovascular System)
Mature Cardiac Fibroblasts Myocardium
Paraxial Mesoderm (Gastrulation Derivatives)
PureStem 7PEND24, NCr-fac & Meso-prx Progenitor

Primer Products:		OriGene qPCR primer pairs and template standards for CXCL6 OriGene qSTAR qPCR primer pairs in human, mouse for CXCL6
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CXCL6
		QuantiTect SYBR Green Assays in human, mouse, rat CXCL6
		QuantiFast Probe-based Assays in human, mouse, rat CXCL6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL6

Orthologs
for CXCL6 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CXCL6 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CXCL6 gene

PPBP²  PF4²  CXCL1²  PF4V1²  CXCL3²  CXCL5²  CXCL2²  IL8²  

12 SIMAP similar genes for CXCL6 using alignment to 2 protein entries:     CXCL6_HUMAN (see all proteins):

CXCL5    IL8    CXCL3    CXCL1    CXCL2    PF4

CXCL10    CXCL12    CXCL9    PF4V1    PPBP    CXCL13

Find genes that share paralogs with CXCL6           About GenesLikeMe

Genomic Variants
for CXCL6 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CXCL6 (see all 125)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs76884851,2	C,A	--	74700367(+)	aacatA/Tcgtgt	1	--	us2k1		1		NA	2
rs1119035791,2	C	--	74700432(+)	TGGGAC/TGGCTG	1	--	us2k1		0	--	--	--	--
rs1923228371,2		--	74700445(+)	TCAAAC/TGGTAT	1	--	us2k1		0	--	--	--	--
rs1814719331,2		--	74700465(+)	TAGATA/CCCTGA	1	--	us2k1		0	--	--	--	--
rs623124151,2	C	--	74700530(+)	AGTGTC/AAAAGT	1	--	us2k1		1		NA	2
rs361919221,2	C	--	74700541(+)	GTTCCT/CATTTC	1	--	us2k1		1		NA	2
rs1870626131,2		--	74700733(+)	CATCCA/GCTTTT	1	--	us2k1		0	--	--	--	--
rs1910511871,2		--	74700736(+)	CCACTA/TTTTGA	1	--	us2k1		0	--	--	--	--
rs1828083321,2	C	--	74700761(+)	TTTTTC/GTTGTA	1	--	us2k1		0	--	--	--	--
rs119309781,2	C,A,H	--	74700826(+)	ggtcgT/Cgaaaa	1	--	us2k1 tfbs3		1		NA	2

HapMap Linkage Disequilibrium report for CXCL6 (74702214 - 74714781 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CXCL6:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv4389	CNV	Insertion	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CXCL6

DNA2.0 Custom Variant and Variant Library Synthesis for CXCL6

Disorders / Diseases
for CXCL6 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

2 diseases for CXCL6

Selected Novoseek inferred disease relationships for CXCL6 gene (see all 16)    About this table

Publications
for CXCL6 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CXCL6 gene, integrated from 10 sources (see all 116): (articles sorted by number of sources associating them with CXCL6)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell- derived neutrophil activating peptide-78 mRNAs. (PubMed id 9057843)^{1, 2, 9} Froyen G.... Billiau A. (Eur. J. Biochem. 1997)
2. Cloning and characterization of the human granulocyte chemotactic protein-2 gene. (PubMed id 9164944)^{1, 2, 9} Rovai L.E.... Smith J.B. (J. Immunol. 1997)
3. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PubMed id 8423327)^{1, 2, 9} Proost P....van Damme J. (J. Immunol. 1993)
4. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. (PubMed id 8399143)^{1, 2, 9} Proost P.... van Damme J. (Biochemistry 1993)
5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (PLoS Genet. 2010)
7. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (Gut 2009)
8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
9. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PubMed id 18563170)^{1, 4} Hillian A.D....Drumm M.L. (Genes Immun. 2008)
10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)^{1, 4} Janssen R....Hoebee B. (J. Infect. Dis. 2007)

External Searches for CXCL6 gene

Genome Databases showing CXCL6 gene

Other Databases showing CXCL6 gene

Specialized Databases showing CXCL6 gene

Products
for CXCL6 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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