Aliases for CXCL5 Gene
External Ids for CXCL5 Gene
Previous HGNC Symbols for CXCL5 Gene
Previous GeneCards Identifiers for CXCL5 Gene
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
GeneCards Summary for CXCL5 Gene
CXCL5 (C-X-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CXCL5 include pediatric ulcerative colitis and pulmonary sarcoidosis. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is PF4.
UniProtKB/Swiss-Prot for CXCL5 Gene
Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.