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CXCL5 Gene

protein-coding   GIFtS: 62
GCID: GC04M074851

Chemokine (C-X-C Motif) Ligand 5

(Previous names: small inducible cytokine subfamily B (Cys-X-Cys), member...)
(Previous symbol: SCYB5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-X-C Motif) Ligand 51 2     ENA-782
SCYB51 2 3 5     C-X-C Motif Chemokine 52
Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 5
(Epithelial-Derived Neutrophil-Activating Peptide 78)1 2
     Neutrophil-Activating Protein 782
Epithelial-Derived Neutrophil-Activating Protein 782 3     ENA-78(1-78)3
Neutrophil-Activating Peptide ENA-782 3     Small-Inducible Cytokine B53
ENA783 5     

External Ids:    HGNC: 106421   Entrez Gene: 63742   Ensembl: ENSG000001637357   OMIM: 6003245   UniProtKB: P428303   

Export aliases for CXCL5 gene to outside databases

Previous GC identifers: GC04M075100 GC04M075263 GC04M075328 GC04M075327 GC04M075226 GC04M070672


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CXCL5 Gene:
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and
activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is
proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to
promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell
proliferation, migration, and invasion. (provided by RefSeq, May 2013)

GeneCards Summary for CXCL5 Gene:
CXCL5 (chemokine (C-X-C motif) ligand 5) is a protein-coding gene. Diseases associated with CXCL5 include nonspecific interstitial pneumonia, and klebsiella. GO annotations related to this gene include chemokine activity. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot: CXCL5_HUMAN, P42830
Function: Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher
chemotactic activity for neutrophil granulocytes

Gene Wiki entry for CXCL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CXCL5 gene promoter:
         HEN1   AML1a   HNF-3beta   Meis-1b   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCXCL5 promoter sequence
   Search Chromatin IP Primers for CXCL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CXCL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

CXCL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXCL5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074851:  view genomic region     (about GC identifiers)

Start:
74,861,359 bp from pter      End:
74,864,496 bp from pter
Size:
3,138 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CXCL5_HUMAN, P42830 (See protein sequence)
Recommended Name: C-X-C motif chemokine 5 precursor  
Size: 114 amino acids; 11972 Da
Secondary accessions: Q96QE1

Explore the universe of human proteins at neXtProt for CXCL5: NX_P42830

Explore proteomics data for CXCL5 at MOPED

Post-translational modifications: 

  • N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from
    peripheral blood monocytes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CXCL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002985.1  
    ENSEMBL proteins: 
     ENSP00000296027  
    Reactome Protein details: P42830

    CXCL5 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CXCL5
    OriGene Protein Over-expression Lysate for CXCL5
    OriGene MassSpec for CXCL5
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    GenScript Purified and Recombinant Proteins for CXCL5
    Novus Biologicals CXCL5 Proteins
    Novus Biologicals CXCL5 Lysates
    Sino Biological Recombinant Protein for CXCL5
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CXCL5
    Browse Proteins at Cloud-Clone Corp.

    CXCL5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CXCL5 (CXCL5/ENA-78)
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    Novus Biologicals CXCL5 Antibodies
    Abcam antibodies for CXCL5
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CXCL5
    LSBio Antibodies in human, mouse, rat for CXCL5

    CXCL5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CXCL5 (CXCL5/ENA-78)         (see all)
    GenScript Custom Assay Services for CXCL5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P42830

    ProtoNet protein and cluster: P42830

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXCL5_HUMAN, P42830
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    CXCL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCL5_HUMAN, P42830
    Function: Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher
    chemotactic activity for neutrophil granulocytes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008009chemokine activity IEA--
         
    CXCL5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CXCL5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CXCL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CXCL5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CXCL5

    miRNA
    Products:
        
    miRTarBase miRNAs that target CXCL5:
    hsa-mir-148b-3p (MIRT019453), hsa-mir-7-5p (MIRT025829)

    Block miRNA regulation of human, mouse, rat CXCL5 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CXCL5:
    hsa-miR-3163 hsa-miR-577 hsa-miR-576-5p hsa-miR-1323 hsa-miR-4263 hsa-miR-548o hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCXCL5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CXCL5
    Predesigned siRNA for gene silencing in human, mouse, rat CXCL5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CXCL5

    Clone
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    OriGene clones in human, mouse for CXCL5 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CXCL5 (NM_002994)
    Sino Biological Human cDNA Clone for CXCL5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL5

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CXCL5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXCL5_HUMAN, P42830: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CXCL5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CXCL5 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine receptors bind chemokines0.81
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CXCL5
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CXCL5 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes
    MIF Mediated Glucocorticoid Regulation


    2 Reactome Pathways for CXCL5
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    5 Kegg Pathways  (Kegg details for CXCL5):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    TNF signaling pathway
    Pertussis
    Rheumatoid arthritis


    CXCL5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL5 (see all 9): 
              Angiogenic Growth Factors in human mouse rat
              Wound Healing in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CXCL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CXCL5 (P428303 ENSP000002960274) via UniProtKB, MINT, STRING, and/or I2D (see all 157)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2P250253, ENSP000003196354I2D: score=3 STRING: ENSP00000319635
    MMP9P147803, ENSP000003614054I2D: score=3 STRING: ENSP00000361405
    CXCR1P250243, ENSP000002956834I2D: score=3 STRING: ENSP00000295683
    DARCQ165703, ENSP000003571034I2D: score=2 STRING: ENSP00000357103
    MMP1P039563I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis TAS10820279
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS10820279
    GO:0007267cell-cell signaling TAS7929219
    GO:0008284positive regulation of cell proliferation TAS10463948

    CXCL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CXCL5

    Selected Novoseek inferred chemical compound relationships for CXCL5 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    groalpha 92.4 32 10540194 (4), 16869002 (4), 11950713 (2), 10513809 (2) (see all 18)
    grogamma 89.7 12 8702798 (5), 9553055 (2), 9054580 (1), 9688939 (1) (see all 5)
    ena 78 89.3 4 17444857 (2), 9064356 (1), 11503269 (1)
    grobeta 85.4 11 8702798 (5), 9553055 (2), 9688939 (1), 19594487 (1)
    rantes 83.6 68 16869002 (4), 17456632 (3), 15899984 (3), 16635746 (2) (see all 42)
    ppbp 73.1 3 10343098 (1), 9465307 (1)
    tarc 54 1 11533168 (1)
    fmlp 46.2 6 10820279 (2), 16873675 (2), 14662891 (1), 8810307 (1)
    ccl3 45.2 3 12851650 (1), 18565769 (1)
    vegf 34.5 13 20137269 (3), 19281539 (2), 16377203 (1), 15860217 (1) (see all 7)



    CXCL5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CXCL5 gene: 
    NM_002994.4  

    Unigene Cluster for CXCL5:

    Chemokine (C-X-C motif) ligand 5
    Hs.89714  [show with all ESTs]
    Unigene Representative Sequence: NM_002994
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296027(uc003hhk.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat CXCL5 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CXCL5:
    hsa-miR-3163 hsa-miR-577 hsa-miR-576-5p hsa-miR-1323 hsa-miR-4263 hsa-miR-548o hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCXCL5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CXCL5
    Predesigned siRNA for gene silencing in human, mouse, rat CXCL5
    Clone
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    OriGene clones in human, mouse for CXCL5 (see all 4)
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    GenScript: all cDNA clones in your preferred vector: CXCL5 (NM_002994)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CXCL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CXCL5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CXCL5
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CXCL5
      QuantiTect SYBR Green Assays in human, mouse, rat CXCL5
      QuantiFast Probe-based Assays in human, mouse, rat CXCL5

    Additional mRNA sequence: 

    AK026546.1 AK312128.1 BC008376.1 BT006807.1 CR457428.1 X78686.1 

    2 DOTS entries:

    DT.97854572  DT.100798582 

    Selected AceView cDNA sequences (see all 135):

    CA308644 CD368760 CB528784 CA434519 CA309519 CD370236 BM832290 AW471084 
    CD370095 BU626594 CD369131 CA308129 CD367083 CD366917 AI270717 CA309414 
    BQ439436 NM_002994 CB528861 CD366914 CD367085 BM990320 CN480795 CA748811 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CXCL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAGTTTC
    CXCL5 Expression
    About this image


    CXCL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
     
     Lung (Respiratory System)
     
     Smooth Muscle (Muscoskeletal System)
    CXCL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CXCL5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89714
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CXCL5 (see all 9): 
              Angiogenic Growth Factors in human mouse rat
              Wound Healing in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Angiogenesis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CXCL5
    OriGene qSTAR qPCR primer pairs in human, mouse for CXCL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CXCL5
    QuantiTect SYBR Green Assays in human, mouse, rat CXCL5
    QuantiFast Probe-based Assays in human, mouse, rat CXCL5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CXCL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CXCL5 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    29(a)
    1 → many
    4(50379773-50381069)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    1 → many
    6(60123888-60134622)
            Species with no ortholog for CXCL5

    ENSEMBL Gene Tree for CXCL5 (if available)
    TreeFam Gene Tree for CXCL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CXCL5 gene
    PPBP2  PF42  CXCL12  PF4V12  CXCL62  CXCL32  CXCL22  IL82  
    11 SIMAP similar genes for CXCL5 using alignment to 2 protein entries:     CXCL5_HUMAN (see all proteins):
    CXCL6    PPBP    IL8    CXCL1    CXCL2    CXCL3
    PF4    CXCL9    PF4V1    CXCL10    CXCL13

    CXCL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CXCL5 (see all 253)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs168503451,2
    C,F,H--74860924(+) ATATGC/TAGGTA 1 -- ds500114Minor allele frequency- T:0.03NA NS EA CSA WA 1352
    rs1417217471,2
    --74860936(+) TGGCCC/TTAGCA 1 -- ds50010--------
    rs1159621921,2
    C,F--74860966(+) AGGAAA/GGAACA 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs1857261111,2
    --74861042(+) GATCAA/GGAATG 1 -- ds50010--------
    rs738246021,2
    C,F--74861066(+) AGAAGG/CTCATC 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs768790701,2
    F--74861087(+) AGAAAC/ACTTTA 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1809327271,2
    --74861091(+) ACCTTC/TATTTT 1 -- ds50010--------
    rs4546181,2
    F,H--74861109(-) AAATTG/CTTTCC 1 -- ds50016Minor allele frequency- C:0.05EA NA NS 438
    rs1505934431,2
    C--74861110(+) GAAACA/GATTTA 1 -- ds50010--------
    rs1863493011,2
    --74861134(+) TTAGAC/TAGGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CXCL5 (74861359 - 74864496 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CXCL5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525980CNV Gain19592680

    Human Gene Mutation Database (HGMD): CXCL5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CXCL5
    DNA2.0 Custom Variant and Variant Library Synthesis for CXCL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600324    OMIM disorders: --

    Selected diseases for CXCL5 (see all 61):    
    About MalaCards
    nonspecific interstitial pneumonia    klebsiella    reactive arthritis    pulmonary sarcoidosis
    bacterial meningitis    interstitial lung disease    idiopathic pulmonary fibrosis    sarcoidosis
    pulmonary emphysema    acute pancreatitis    hemolytic-uremic syndrome    severe acute respiratory syndrome
    adrenocortical carcinoma    pneumonia    endometriosis    gastritis
    abdominal aortic aneurysm    pertussis    pulmonary fibrosis    paget's disease of bone

    1 disease from the University of Copenhagen DISEASES database for CXCL5:
    Lung disease

    CXCL5 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CXCL5 gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrosis idiopathic pulmonary 59.5 7 20137269 (2), 16085216 (2), 11751193 (1), 19117745 (1)
    inflammation 50.6 15 18769620 (3), 11046061 (1), 9553055 (1), 9620668 (1) (see all 8)
    bronchoalveolar lavage fluid 45.3 4 8810593 (1), 16085216 (1), 18644457 (1), 14662873 (1)
    necrosis 43.8 18 16553183 (2), 1744577 (1), 8083342 (1), 12972516 (1) (see all 15)
    rheumatoid arthritis 39 6 9365115 (1), 10358204 (1), 18576313 (1), 9232436 (1) (see all 5)
    pneumonitis hypersensitivity 35.8 1 19117745 (1)
    colitis ulcerative 34.9 9 9252512 (4), 10535602 (1), 9365115 (1), 11559712 (1) (see all 6)
    endometriosis 34.3 25 12620496 (5), 15837658 (5), 14967364 (4), 16553183 (3) (see all 5)
    sarcoidosis pulmonary 31.1 3 17052298 (3)
    sarcoidosis 23.9 5 17052298 (2), 19117745 (1), 17035428 (1)

    Genetic Association Database (GAD): CXCL5
    Human Genome Epidemiology (HuGE) Navigator: CXCL5 (13 documents)

    Export disorders for CXCL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CXCL5 gene, integrated from 10 sources (see all 265):
    (articles sorted by number of sources associating them with CXCL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene. (PubMed id 7929219)1, 2, 3, 9 Chang M.S.... Simonet S. (J. Biol. Chem. 1994)
    2. CXCL5 gene polymorphisms are related to systemic concentrations and leukocyte production of epithelial neutrophil-activating peptide (ENA-78). (PubMed id 16567110)1, 4, 9 Zineh I....Schofield R.S. (Cytokine 2006)
    3. Epithelial neutrophil-activating peptide (ENA-78), acute coronary syndrome prognosis, and modulatory effect of statins. (PubMed id 18769620)1, 4, 9 Zineh I....Spertus J.A. (PLoS ONE 2008)
    4. Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8. (PubMed id 1744577)1, 2, 9 Walz A....Strieter R.M. (J. Exp. Med. 1991)
    5. [Association of ENA-78, IP-10 and VEGF gene polymorphism with idiopathic pulmonary fibrosis]. (PubMed id 20137269)1, 4, 9 Liu L....Xin P. (Zhonghua Yi Xue Za Zhi 2009)
    6. Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78). (PubMed id 7999089)1, 2, 9 Corbett M.S.... Walz A. (Biochem. Biophys. Res. Commun. 1994)
    7. CXCL5 gene polymorphism association with diabetes mellitus. (PubMed id 19035625)1, 4, 9 Hasani Ranjbar S....Amoli M.M. (amp 2008)
    8. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PubMed id 10095777)1, 2, 9 Wuyts A.... Van Damme J. (Eur. J. Biochem. 1999)
    9. Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets. (PubMed id 7828901)1, 2, 9 Power C.A.... Wells T.N.C. (Gene 1994)
    10. Regulated upon activation normal T-cell expressed and secreted (RANTES) and epithelial cell-derived neutrophil-activating peptide (ENA-78) gene polymorphisms in patients with biopsy-proven erythema nodosum. (PubMed id 19646363)1, 4, 9 Amoli M.M....Gonzalez-Gay M.A. (Clin. Exp. Rheumatol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6374 HGNC: 10642 AceView: CXCL5 Ensembl:ENSG00000163735 euGenes: HUgn6374
    ECgene: CXCL5 Kegg: 6374 H-InvDB: CXCL5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CXCL5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CXCL5 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CXCL5

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CXCL5 gene:
    Search GeneIP for patents involving CXCL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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