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Aliases for CXCL5 Gene

Aliases for CXCL5 Gene

  • C-X-C Motif Chemokine Ligand 5 2 3
  • Chemokine (C-X-C Motif) Ligand 5 2 3 5
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 5 (Epithelial-Derived Neutrophil-Activating Peptide 78) 2 3
  • Epithelial-Derived Neutrophil-Activating Protein 78 3 4
  • Neutrophil-Activating Peptide ENA-78 3 4
  • SCYB5 3 4
  • Neutrophil-Activating Protein 78 3
  • Small-Inducible Cytokine B5 4
  • ENA-78(1-78) 4
  • ENA-78 3
  • ENA78 4

External Ids for CXCL5 Gene

Previous HGNC Symbols for CXCL5 Gene

  • SCYB5

Previous GeneCards Identifiers for CXCL5 Gene

  • GC04M074851
  • GC04M075100
  • GC04M075263
  • GC04M075328
  • GC04M075327
  • GC04M075226
  • GC04M070672

Summaries for CXCL5 Gene

Entrez Gene Summary for CXCL5 Gene

  • This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

GeneCards Summary for CXCL5 Gene

CXCL5 (C-X-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CXCL5 include Pediatric Ulcerative Colitis and Pulmonary Sarcoidosis. Among its related pathways are Peptide ligand-binding receptors and TNF signaling pathway. GO annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for CXCL5 Gene

  • Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.

Gene Wiki entry for CXCL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL5 Gene

Genomics for CXCL5 Gene

Regulatory Elements for CXCL5 Gene

Enhancers for CXCL5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CXCL5 on UCSC Golden Path with GeneCards custom track

Promoters for CXCL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CXCL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCL5 Gene

Chromosome:
4
Start:
73,995,642 bp from pter
End:
73,998,779 bp from pter
Size:
3,138 bases
Orientation:
Minus strand

Genomic View for CXCL5 Gene

Genes around CXCL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL5 Gene

Proteins for CXCL5 Gene

  • Protein details for CXCL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42830-CXCL5_HUMAN
    Recommended name:
    C-X-C motif chemokine 5
    Protein Accession:
    P42830
    Secondary Accessions:
    • Q96QE1

    Protein attributes for CXCL5 Gene

    Size:
    114 amino acids
    Molecular mass:
    11972 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCL5 Gene

neXtProt entry for CXCL5 Gene

Proteomics data for CXCL5 Gene at MOPED

Post-translational modifications for CXCL5 Gene

  • N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CXCL5 Gene

Domains & Families for CXCL5 Gene

Gene Families for CXCL5 Gene

Protein Domains for CXCL5 Gene

Suggested Antigen Peptide Sequences for CXCL5 Gene

Graphical View of Domain Structure for InterPro Entry

P42830

UniProtKB/Swiss-Prot:

CXCL5_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL5: view

Function for CXCL5 Gene

Molecular function for CXCL5 Gene

UniProtKB/Swiss-Prot Function:
Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.

Phenotypes for CXCL5 Gene

GenomeRNAi human phenotypes for CXCL5:
genes like me logo Genes that share phenotypes with CXCL5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL5 Gene

Localization for CXCL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL5 Gene COMPARTMENTS Subcellular localization image for CXCL5 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CXCL5 Gene

Pathways & Interactions for CXCL5 Gene

genes like me logo Genes that share pathways with CXCL5: view

Gene Ontology (GO) - Biological Process for CXCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 10820279
GO:0006955 immune response IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007267 cell-cell signaling TAS 7929219
genes like me logo Genes that share ontologies with CXCL5: view

No data available for SIGNOR curated interactions for CXCL5 Gene

Drugs & Compounds for CXCL5 Gene

(10) Drugs for CXCL5 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
hmg coa reductase inhibitors Pharma 0

(14) Additional Compounds for CXCL5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL5: view

Transcripts for CXCL5 Gene

mRNA/cDNA for CXCL5 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(135) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL5 Gene

Chemokine (C-X-C motif) ligand 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL5 Gene

No ASD Table

Relevant External Links for CXCL5 Gene

GeneLoc Exon Structure for
CXCL5
ECgene alternative splicing isoforms for
CXCL5

Expression for CXCL5 Gene

mRNA expression in normal human tissues for CXCL5 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL5 Gene

This gene is overexpressed in Minor Salivary Gland (x5.1).

Protein differential expression in normal tissues from HIPED for CXCL5 Gene

This gene is overexpressed in Stomach (58.2) and Platelet (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CXCL5 Gene



SOURCE GeneReport for Unigene cluster for CXCL5 Gene Hs.89714

genes like me logo Genes that share expression patterns with CXCL5: view

Protein tissue co-expression partners for CXCL5 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CXCL5 Gene

Orthologs for CXCL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CXCL6 35
  • 79.2 (n)
  • 74.31 (a)
CXCL6 36
  • 75 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CXCL5 35
  • 98.54 (n)
  • 97.37 (a)
CXCL5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cxcl5 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
OneToMany
Species with no ortholog for CXCL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL5 Gene

ENSEMBL:
Gene Tree for CXCL5 (if available)
TreeFam:
Gene Tree for CXCL5 (if available)

Paralogs for CXCL5 Gene

Paralogs for CXCL5 Gene

(11) SIMAP similar genes for CXCL5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CXCL5: view

Variants for CXCL5 Gene

Sequence variations from dbSNP and Humsavar for CXCL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs352047 -- 73,996,373(-) AGCGG(C/G)AGCGG utr-variant-3-prime
rs454618 -- 73,995,392(-) AAATT(C/G)TTTCC downstream-variant-500B
rs3211020 -- 73,995,965(-) GGATT(C/G)TGTGA utr-variant-3-prime
rs3211021 -- 73,995,955(-) ATAAT(A/G)TTTAA utr-variant-3-prime
rs16850345 -- 73,995,207(+) ATATG(C/T)AGGTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CXCL5 Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV Gain 19592680

Variation tolerance for CXCL5 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCL5 Gene

Human Gene Mutation Database (HGMD)
CXCL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL5 Gene

Disorders for CXCL5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CXCL5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pediatric ulcerative colitis
  • ulcerative colitis, pediatric
pulmonary sarcoidosis
  • lung sarcoidosis
nonspecific interstitial pneumonia
  • nsip
cerebritis
pulmonary fibrosis, idiopathic
  • idiopathic pulmonary fibrosis
- elite association - COSMIC cancer census association via MalaCards
Search CXCL5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCL5

Genetic Association Database (GAD)
CXCL5
Human Genome Epidemiology (HuGE) Navigator
CXCL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCL5
genes like me logo Genes that share disorders with CXCL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL5 Gene

Publications for CXCL5 Gene

  1. Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene. (PMID: 7929219) Chang M.S. … Simonet S. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. Epithelial neutrophil-activating peptide-78 recruits neutrophils into pleural effusion. (PMID: 19047312) Liu G.N. … Wu Y.B. (Eur. Respir. J. 2009) 3 23
  3. Regulated upon activation normal T-cell expressed and secreted (RANTES) and epithelial cell-derived neutrophil-activating peptide (ENA-78) gene polymorphisms in patients with biopsy-proven erythema nodosum. (PMID: 19646363) Amoli M.M. … Gonzalez-Gay M.A. (Clin. Exp. Rheumatol. 2009) 3 23
  4. [Association of ENA-78, IP-10 and VEGF gene polymorphism with idiopathic pulmonary fibrosis]. (PMID: 20137269) Liu L. … Xin P. (Zhonghua Yi Xue Za Zhi 2009) 3 23
  5. Basal and cytokine-stimulated production of epithelial neutrophil activating peptide-78 (ENA-78) and interleukin-8 (IL-8) by cultured human endometrial epithelial and stromal cells. (PMID: 17761179) Bersinger N.A. … Mueller M.D. (Fertil. Steril. 2008) 3 23

Products for CXCL5 Gene

Sources for CXCL5 Gene

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