Aliases for CXCL5 Gene
External Ids for CXCL5 Gene
Previous HGNC Symbols for CXCL5 Gene
Previous GeneCards Identifiers for CXCL5 Gene
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
GeneCards Summary for CXCL5 Gene
CXCL5 (C-X-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CXCL5 include Pediatric Ulcerative Colitis and Pulmonary Sarcoidosis. Among its related pathways are Peptide ligand-binding receptors and TNF signaling pathway. GO annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is PF4.
UniProtKB/Swiss-Prot for CXCL5 Gene
Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.