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Aliases for CXCL5 Gene

Aliases for CXCL5 Gene

  • Chemokine (C-X-C Motif) Ligand 5 2 3
  • SCYB5 3 4 6
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 5 (Epithelial-Derived Neutrophil-Activating Peptide 78) 2 3
  • Epithelial-Derived Neutrophil-Activating Protein 78 3 4
  • Neutrophil-Activating Peptide ENA-78 3 4
  • ENA78 4 6
  • Neutrophil-Activating Protein 78 3
  • Small-Inducible Cytokine B5 4
  • C-X-C Motif Chemokine 5 3
  • ENA-78(1-78) 4
  • ENA-78 3

External Ids for CXCL5 Gene

Previous HGNC Symbols for CXCL5 Gene

  • SCYB5

Previous GeneCards Identifiers for CXCL5 Gene

  • GC04M074851
  • GC04M075100
  • GC04M075263
  • GC04M075328
  • GC04M075327
  • GC04M075226
  • GC04M070672

Summaries for CXCL5 Gene

Entrez Gene Summary for CXCL5 Gene

  • This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

GeneCards Summary for CXCL5 Gene

CXCL5 (Chemokine (C-X-C Motif) Ligand 5) is a Protein Coding gene. Diseases associated with CXCL5 include pulmonary sarcoidosis and nonspecific interstitial pneumonia. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include chemokine activity. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot for CXCL5 Gene

  • Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.

Gene Wiki entry for CXCL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL5 Gene

Genomics for CXCL5 Gene

Regulatory Elements for CXCL5 Gene

Genomic Location for CXCL5 Gene

Start:
73,995,642 bp from pter
End:
73,998,779 bp from pter
Size:
3,138 bases
Orientation:
Minus strand

Genomic View for CXCL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL5 Gene

Proteins for CXCL5 Gene

  • Protein details for CXCL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42830-CXCL5_HUMAN
    Recommended name:
    C-X-C motif chemokine 5
    Protein Accession:
    P42830
    Secondary Accessions:
    • Q96QE1

    Protein attributes for CXCL5 Gene

    Size:
    114 amino acids
    Molecular mass:
    11972 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCL5 Gene

neXtProt entry for CXCL5 Gene

Proteomics data for CXCL5 Gene at MOPED

Post-translational modifications for CXCL5 Gene

  • N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for CXCL5 Gene

Domains for CXCL5 Gene

Gene Families for CXCL5 Gene

HGNC:

Protein Domains for CXCL5 Gene

Suggested Antigen Peptide Sequences for CXCL5 Gene

Graphical View of Domain Structure for InterPro Entry

P42830

UniProtKB/Swiss-Prot:

CXCL5_HUMAN :
  • P42830
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL5: view

Function for CXCL5 Gene

Molecular function for CXCL5 Gene

UniProtKB/Swiss-Prot Function: Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.

Gene Ontology (GO) - Molecular Function for CXCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IEA --
GO:0045236 CXCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CXCL5: view

Animal Model Products

CRISPR Products

miRNA for CXCL5 Gene

miRTarBase miRNAs that target CXCL5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CXCL5 Gene

Localization for CXCL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCL5 Gene COMPARTMENTS Subcellular localization image for CXCL5 gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CXCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CXCL5: view

Pathways for CXCL5 Gene

genes like me logo Genes that share pathways with CXCL5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenesis in human,mouse,rat
    • Angiogenic Growth Factors in human,mouse,rat
    • Chemokines & Receptors in human,mouse,rat
    • Cytokines & Chemokines in human,mouse,rat
    • Inflammatory Cytokines & Receptors in human,mouse,rat

Gene Ontology (GO) - Biological Process for CXCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002446 neutrophil mediated immunity IBA --
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 10820279
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with CXCL5: view

Compounds for CXCL5 Gene

(23) Novoseek inferred chemical compound relationships for CXCL5 Gene

Compound -log(P) Hits PubMed IDs
groalpha 92.4 28
grogamma 89.7 10
ena 78 89.3 4
grobeta 85.4 9
rantes 83.6 54

(1) PharmGKB related drug/compound annotations for CXCL5 Gene

Drug/compound Annotation
hmg coa reductase inhibitors CA
genes like me logo Genes that share compounds with CXCL5: view

Transcripts for CXCL5 Gene

mRNA/cDNA for CXCL5 Gene

(135) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL5 Gene

Chemokine (C-X-C motif) ligand 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCL5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL5 Gene

No ASD Table

Relevant External Links for CXCL5 Gene

GeneLoc Exon Structure for
CXCL5
ECgene alternative splicing isoforms for
CXCL5

Expression for CXCL5 Gene

mRNA expression in normal human tissues for CXCL5 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL5 Gene

This gene is overexpressed in Minor Salivary Gland (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CXCL5 Gene

SOURCE GeneReport for Unigene cluster for CXCL5 Gene Hs.89714

genes like me logo Genes that share expressions with CXCL5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CXCL5 Gene

Orthologs for CXCL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL5 35
  • 98.54 (n)
  • 97.37 (a)
CXCL5 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL6 35
  • 79.2 (n)
  • 74.31 (a)
CXCL6 36
  • 75 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cxcl5 36
  • 45 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
OneToMany
Species with no ortholog for CXCL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL5 Gene

ENSEMBL:
Gene Tree for CXCL5 (if available)
TreeFam:
Gene Tree for CXCL5 (if available)

Paralogs for CXCL5 Gene

Paralogs for CXCL5 Gene

Selected SIMAP similar genes for CXCL5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CXCL5: view

Variants for CXCL5 Gene

Sequence variations from dbSNP and Humsavar for CXCL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs352045 -- 73,998,970(-) CTGGC(A/C)CAGGC upstream-variant-2KB
rs352046 -- 73,998,833(-) CTCCC(C/G)ACCAG upstream-variant-2KB
rs425535 -- 73,998,280(-) ACGCA(A/G)GGAGT reference, synonymous-codon
rs454618 -- 73,995,392(-) AAATT(C/G)TTTCC downstream-variant-500B
rs1540413 -- 73,999,413(-) ACACA(C/T)GTATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXCL5 Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV Gain 19592680

Relevant External Links for CXCL5 Gene

HapMap Linkage Disequilibrium report
CXCL5
Human Gene Mutation Database (HGMD)
CXCL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL5 Gene

Disorders for CXCL5 Gene

(1) University of Copenhagen DISEASES for CXCL5 Gene

(30) Novoseek inferred disease relationships for CXCL5 Gene

Disease -log(P) Hits PubMed IDs
fibrosis idiopathic pulmonary 59.5 6
inflammation 50.6 10
bronchoalveolar lavage fluid 45.3 4
necrosis 43.8 16
rheumatoid arthritis 39 5

Relevant External Links for CXCL5

Genetic Association Database (GAD)
CXCL5
Human Genome Epidemiology (HuGE) Navigator
CXCL5
genes like me logo Genes that share disorders with CXCL5: view

No data available for UniProtKB/Swiss-Prot for CXCL5 Gene

Publications for CXCL5 Gene

  1. Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene. (PMID: 7929219) Chang M.S. … Simonet S. (J. Biol. Chem. 1994) 2 3 4 23
  2. Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78). (PMID: 7999089) Corbett M.S. … Walz A. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  3. Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8. (PMID: 1744577) Walz A. … Strieter R.M. (J. Exp. Med. 1991) 3 4 23
  4. Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets. (PMID: 7828901) Power C.A. … Wells T.N.C. (Gene 1994) 3 4 23
  5. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. (PMID: 10095777) Wuyts A. … Van Damme J. (Eur. J. Biochem. 1999) 3 4 23

Products for CXCL5 Gene

Sources for CXCL5 Gene

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